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au:SOUZA, ALINE F.

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Phytosociology of an open arboreal caatinga with high basal area in the Seridó desertification region, Brazil
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Medeiros, Aline V. S. de

; Guedes, Rozileudo da S.

; Souza, Pierre F. de

; Zanella, Fernando C. V.

Revista Caatinga

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sep 2023, Volume 36 N. 3 Pages 601 - 611

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Seridó is one of the driest regions in the Caatinga biome, Northeastern Brazil, affected by a long history of anthropogenic impact, and today it is considered a desertification region. A phytosociological survey of woody species was carried out in an area at Morada das Jandairas Farm (MJF), in Santana do Seridó, Rio Grande do Norte, which still has a significant arboreal component despite maintaining an extensive cattle production, and compared it with data from other five inventories carried out in the region. Seventeen species from ten botanical families were found, with Fabaceae and Euphorbiaceae being the most diversified. Commiphora leptophloeos and Croton blanchetianus stood out as the most important species. The high floristic composition similarity among the six compared studies indicates that the different phytophysiognomies may be result of anthropogenic action and regeneration processes. The relatively high Basal Area in the MJF (26.8 m2 ha-1) stands out even considering inventories carried out throughout the Caatinga region, which is largely due to the presence of many large trees (C. leptophloeos). Considerations about the ecological importance of large and old trees are made, with recommendations for the methodology of phytosociological inventories.

RESUMO A região do Seridó é uma das mais áridas do bioma caatinga, região Nordeste do Brasil, sendo afetada por uma longa história de impacto antrópico, e hoje considerada um núcleo de desertificação. Realizamos um levantamento fitossociológico das espécies arbustivo-arbóreas de uma área ainda com um componente arbóreo significativo, apesar de ainda ser utilizada para criação extensiva de gado, Fazenda Morada das Jandaíras (FMJ), e comparamos com dados de outros inventários realizados na região. Foram registradas 17 espécies pertencentes a 10 famílias botânicas, sendo Fabaceae e Euphorbiaceae as mais diversificadas. Commiphora leptophloeos e Croton blanchetianus se destacaram como as espécies de maiores valores de importância. A alta similaridade na composição florística entre os seis estudos comparados foi interpretada como indicador de que as diferentes fitofisionomias podem ser resultado de ação antrópica e processos de regeneração. A relativamente elevada Dominância Basal na FMJ, da ordem de 26,8 m2 ha-1, se destaca mesmo considerando inventários realizados em toda a região de caatinga, sendo em grande parte devida à presença de muitas árvores de grande porte de C. leptophloeos. Considerações sobre a importância ecológica de árvores grandes e antigas são feitas, com recomendações para a metodologia de inventários fitossociológicos.

https://doi.org/10.1590/1983-21252023v36n313rc

Long-term hepatic damage in high-fructose-fed C57BL/6 mice: hepatic fibrogenesis, endoplasmic reticulum stress markers, and fibrosis
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OLIVEIRA-CORDEIRO, BRENDA

; FERNANDES-DA-SILVA, ALINE

; SILVA-VEIGA, FLAVIA MARIA

; MIRANDA, CAROLLINE S.

; MARTINS, FABIANE F.

; SOUZA-MELLO, VANESSA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Suppl. 2 elocation e20220784

Abstract: En | Text: En | PDF: En

Abstract The rising fructose intake in sugar-sweetened beverages and ultra-processed foods relates to the high incidence of nonalcoholic fatty liver disease. This study aimed to examine the effects of long-term high-fructose diet intake (for 16 or 20 weeks) on progressive hepatic damage, focusing on the endoplasmic reticulum stress markers and fibrogenesis as possible triggers of liver fibrosis. Forty 3-month-old male C57BL/6J mice were randomly divided into four nutritional groups: C16 (control diet for 16 weeks), C20 (control diet for 20 weeks), HFRU16 (high-fructose diet for 16 weeks), and HFRU20 (high-fructose diet for 20 weeks). Both HFRU groups showed oral glucose intolerance and insulin resistance, but only the HFRU20 group exhibited increased inflammation. The increased lipogenic and endoplasmic reticulum stress markers triggered hepatic fibrogenesis. Hence, time-dependent perivascular fibrosis with positive immunostaining for alpha-smooth muscle actin and reelin in HFRU mice was observed, ensuring fibrosis development in this mouse model. Our study showed time-dependent and progressive damage on hepatic cytoarchitecture, with maximization of hepatic steatosis without overweight in HFRU20 mice. ER stress and liver inflammation could mediate hepatic stellate cell activation and fibrogenesis, emerging as targets to prevent NAFLD progression and fibrosis onset in this dietary model.

https://doi.org/10.1590/0001-3765202320220784

Marine fish and benthic biota before the 2019 oil spill: A baseline dataset for monitoring programs and impact assessments at Rio Grande Norte state, Northeastern Brazil
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VIANA, MARINA G.

; LIMA, MAURO S.P.

; MARTINEZ, ALINE S.

; BARBOZA, ALINA R.P.

; MELO, CLARA, S.

; CALADO, JANAÍNA F.

; GRIMALDI, GUIDO G.

; SOUZA, THAISA A.

; LEITE, TATIANA S.

; MENDES, LIANA F.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 elocation e20210536

Abstract: En | Text: En | PDF: En

Abstract In 2019 an oil spill spread over more than 4000 km of the Brazilian coastline. Monitoring programs that allow for the evaluation of potential impacts on communities and ecosystems and their recovery through time are needed and rely on baseline information previous to the oil spill. Here we compiled qualitative and quantitative data available from 8 studies on fish and benthic species from different habitats of Rio Grande do Norte (RN) from 2007 to 2018. We assessed the number of species from different locations and compiled information on conservation status and human use. We mapped the study areas and habitats and overlapped them with those affected by the oil spill. The RN state has a high diversity of fish (175 species) and benthic species (285 species), of which more than half of fish (52%) and 2% of benthic species are threatened and 72,8% of fish and 7,9% of benthic species are of commercial interest. Information of most habitats is still poorly known (i.e.majority ofthe available data are from unique and punctual sampling), which may weaken future evaluations of the real impact of the oil spill. Nonetheless, it is possible to design reliable monitoring based on our dataset, persistent contamination and future loss of diversity.

https://doi.org/10.1590/0001-3765202120210536

Shading and slow release fertiliser affect early growth in seedlings of Pau-marfim
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Smiderle, Oscar José

; Souza, Aline das Graças

; Menegatti, Renata Diane

; Dias, Thiago Jardelino

; Montenegro, Raiovane Araújo

Floresta e Ambiente

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2021, Volume 28 N. 1 elocation e20200023

Abstract: En | Text: En | PDF: En

Abstract The aim of this study was to evaluate the initial growth of Agonandra brasiliensis Miers ex Benth. & Hook. F. in response to different levels of shading and doses of controlled-release fertiliser (CRF). The experiment was conducted at Embrapa Roraima in Boa Vista, in a completely randomised experimental design and a 2 x 5 factorial scheme, of two luminosity levels (50 and 30%) and five doses of CRF (formulation 18-05-09, NPK) (0, 0.5, 1, 2 and 3 g L-1 substrate), with five replications, each consisting of five plants. At 240 days after transplanting, the growth characteristics were evaluated, and the influence of the light levels and the CRF dose was recorded on these characteristics, either individually or interactively. It is suggested that plants of Agonandra brasiliensis be fertilised with a dose of 2 g L-1 CRF and grown in an environment with 50% of luminosity to maximize growth and efficiency in the production of high-quality seedlings.

https://doi.org/10.1590/2179-8087-floram-2020-0023 448 downloads

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Abstract: En | Text: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

ABSORPTIVE CAPACITY OF SIGNALS CAPTURED FROM ENVIRONMENT FOR INNOVATION
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SOUZA, SHIRLEY A.

; SILVA, DÉBORA E. P.

; ABREU, ALINE F.

RAM. Revista de Administração Mackenzie

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2019, Volume 20 N. 6 elocation eRAMD190029

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever a capacidade absortiva (ACAP) de empresas industriais sergipanas, do segmento de confecção têxtil, para os sinais capturados do ambiente que indicam necessidade de inovação em resposta às mudanças do mercado. As bases teóricas da capacidade absortiva postulam que a empresa que desenvolve essa capacidade possui habilidade em reconhecer o valor da informação, assimilá-la e aplicá-la para fins comerciais e, desse modo, desenvolver competências que lhe possibilitem alcançar vantagem competitiva. Originalidade/valor: Do ponto de vista teórico, foram elencados os fatores que estimulam as empresas de confecções a reconhecer, assimilar, transformar e explorar o conhecimento externo. Quanto às contribuições práticas, a pesquisa pode fornecer referências às organizações que desejarem ampliar ou desenvolver a absorção de novos conhecimentos, de modo que estes promovam melhoria na atividade organizacional e inovação. Design/metodologia/abordagem: As empresas são de micro a médio porte e desenvolvem inovações em processo e marketing. Para a realização da pesquisa, foi construído um instrumento de coleta qualitativo que foi aplicado em sete empresas com características inovadoras comparadas à concorrência local. Resultados: O resultado mostra que as indústrias analisadas buscam renovação do conhecimento existente e assimilam as informações externas para se adaptar e transformar suas estratégias organizacionais. A exploração do conhecimento ocorre a partir das relações com clientes e fornecedores, do conhecimento prévio das lideranças e da estrutura existente na organização. As empresas que melhor apresentaram a ACAP foram as que enfrentaram concorrência direta, pois a sua presença criou estímulos para a realização da busca por informações para se diferenciarem e se tornarem competitivas.

ABSTRACT Purpose: This article aims to describe the absorptive capacity (ACAP) of textile manufacturing industrial companies of Sergipe state, Brazil, for the signals captured from the environment, indicating the need for innovation in response to changes in the market. The theoretical bases of absorptive capacity postulate that a company that develops this capacity has the ability to recognize the information value, assimilate it, and apply it for commercial purposes. They can develop skills that allow them to achieve competitive advantage. Originality/value: From the theoretical point of view, the factors that stimulate the apparel companies to recognize, assimilate, transform, and exploit the external knowledge were listed. Regarding the practical contributions, the study can provide references to organizations wishing to extend or develop the absorption of new knowledge, so this can promote improvement in organizational activity and innovation. Design/methodology/approach: For the study, it was built a qualitative data collection instrument. The instrument had been applied in seven companies with innovative characteristics when compared to the local competition. Companies are micro to medium-sized and develop innovations in process and marketing. Findings: The result shows that the analyzed companies look for renewal of existing knowledge and assimilate the external information to adapt and transform their organizational strategies. The exploitation of knowledge occurs from relationships with customers and suppliers, prior knowledge of leadership and organization existing structure. Companies with best ACAP were those who faced direct competition. This fact has created incentives for the search for information to differentiate the companies and make them competitive.

https://doi.org/10.1590/1678-6971/eramd190029 1237 downloads

Synthesis of 3,5-Diarylisoxazole Derivatives and Evaluation of in vitro Trypanocidal Activity
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Souza, Aline A. N. de

; Xavier, Viviane F.

; Coelho, Gleicekelly S.

; Sales Junior, Policarpo A.

; Romanha, Alvaro J.

; Murta, Silvane M. F.

; Carneiro, Claudia M.

; Taylor, Jason G.

Journal of the Brazilian Chemical Society

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feb 2018, Volume 29 N. 2 Pages 269 - 277

Abstract: En | Text: En | PDF: En

Chagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazoles were obtained by reaction of flavones and hydroxylamine and either alkylated at the free hydroxyl group and/or nitrated at the isoxazole ring. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as a reference compound for the in vitro assay and mammalian L929 cells were employed to evaluate cytotoxicity. A majority of the compounds tested were very active and the most active isoxazole against amastigote and trypomastigotes of T. cruzi was slightly more potent than the current medicine benznidazole.

https://doi.org/10.21577/0103-5053.20170137 1593 downloads

Combination of Transversus abdominis plane block and Serratus plane block anesthesia in dogs submitted to masctetomy
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Teixeira, Luciana G.

; Pujol, Diego M.

; Pazzim, Aline F.

; Souza, Renata P.

; Fadel, Leandro

Pesquisa Veterinária Brasileira

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feb 2018, Volume 38 N. 2 Pages 315 - 319

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este trabalho pretende demonstrar o efeito analgésico da combinação das técnicas de bloqueio do plano transverso abdominal (TAP block) e bloqueio do plano serrátil (SP block) em 4 cadelas submetidas à mastectomia unilateral total. Os animais foram pré-medicados com metadona (0,5mg.kg-1) por via intramuscular. A anestesia foi induzida com propofol (6mg.kg-1) e midazolam (0,3mg.kg-1) e mantida com isoflurano. Os bloqueios SP e TAP foram realizados unilateralmente, utilizando ultrassonografia, pela injeção de bupivacaína a 0,25% (0,3mL.kg-1), diluída com solução de NaCl a 1:1. A frequência cardíaca (FC), frequência respiratória (f), pressão arterial não invasiva, temperatura esofágica (T), saturação de oxigênio (SpO2) e eletrocardiograma foram monitorados continuamente. Os animais foram monitorizados durante duras e quatro horas após a extubação para a dor usando a Escala de Dor Aguda Canina da Universidade Estadual do Colorado. Duas horas após a extubação, tramadol (4mg.kg-1) e dipirona (25mg.kg-1) foram administrados a todos os cães. Não foi observada qualquer alteração no ritmo cardíaco. HR, f, T e pressão arterial média permaneceram abaixo dos valores basais para todos os cães. Nenhum cão requereu resgate analgésico intra-operatório. Não houve complicações na recuperação anestésica. Todos os animais apresentaram escore 0 (0/5) na escala de dor, duras e 4 quatrohoras após a extubação e nenhum expressou desconforto com a ferida cirúrgica. Todos os cães foram capazes de caminhar antes de duas horas após extubação. A combinação de ambas as técnicas é eficaz no bloqueio anestésico das paredes torácica e abdominal e sugere-se que ambos podem ser incluídos nos protocolos de analgesia multimodal para este tipo de cirurgia.

ABSTRACT: This paper pretends to demonstrate the effect of the combination of transversus abdominis plane block (TAP block) and Serratus plane block (SP block) techniques in analgesia of 4 dogs undergoing total unilateral mastectomy. Dogs were premedicated with methadone (0.5mg.kg-1) intramuscularly. Anesthesia was induced with propofol (6mg.kg-1) and midazolam (0.3mg.kg-1) and maintained with isoflurane. SP and TAP block were performed unilaterally using ultrasound by the injection of bupivacaine 0.25% (0.3mL kg-1) diluted with NaCl solution 1:1. Heart rate (HR), respiratory rate (f), non-invasive arterial pressure, esophageal temperature (T), oxygen saturation (SpO2) and electrocardiogram were monitored continuously. Animals were monitored for two and four hours after extubation for pain by using the Canine Acute Pain Scale from Colorado State University. Two hours after extubation, tramadol (4mg.kg-1) and dipyrone (25mg.kg-1) was administered to all dogs. It was not observed any alteration on cardiac rhythm. HR, f, T and mean arterial pressure remained below the preincisional values for all dogs. No dog required intraoperative rescue analgesia. Recovery from anesthesia was without any complication. All animals scored 0 (0/5) at pain scale, two and four hours after extubation and none of them expressed concern over the surgical wound. Dogs were able to walk before two hours after extubation. The combination of both techniques is effective in anesthetic blocking the thoracic and abdominal walls and it is suggested both may be included in the multimodal analgesia protocols for this type of surgery.

https://doi.org/10.1590/1678-5150-pvb-5007 5200 downloads

METABOLÔMICA: DEFINIÇÕES, ESTADO-DA-ARTE E APLICAÇÕES REPRESENTATIVAS
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Canuto, Gisele A. B.

; Costa, José Luiz da

; Cruz, Pedro L. R. da

; Souza, Ana Rosa L. de

; Faccio, Andréa T.

; Klassen, Aline

; Rodrigues, Karina T.

; Tavares, Marina F. M.

Química Nova

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jan 2018, Volume 41 N. 1 Pages 75 - 91

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Metabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control groups with altered groups, undergoing different therapies, submitted to differing stress levels, dietary modulation, or promoted by a disease, or specific condition, etc., using sophisticated analytical techniques, and advanced data treatment and statistical analyses. In this review, the concepts involved in metabolomics studies were presented, describing in details all steps involved in the metabolomics workflow, for untargeted and targeted strategies. Finally, the potential of metabolomics is illustrated by applications in representative areas: clinical, environmental, food and nutrition, forensic toxicology, microbiology, parasitology, plants, and sports. Relevant reviews were compiled to characterize each of these areas, and a corresponding application of untargeted and targeted metabolomics were described.

https://doi.org/10.21577/0100-4042.20170134 23276 downloads

10.

Twenty minutes of post-exercise hypotension are enough to predict chronic blood pressure reduction induced by resistance training in older women
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Eches, Erick H. P.

; Ribeiro, Alex S.

; Gerage, Aline M.

; Tomeleri, Crisieli M.

; Souza, Mariana F.

; Nascimento, Matheus A.

; Cavalcante, Edilaine F.

; Schiavoni, Durcelina

; Christofaro, Diego G. D.

; Gurjão, André Luiz D.

; Mayhew, Jerry L.

; Cyrino, Edilson S.

Motriz: Revista de Educação Física

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2018, Volume 24 N. 1 elocation e1018142

Abstract: En | Text: En | PDF: En

Abstract AIM This study investigated the correlation between post-exercise hypotension (PEH) and chronic blood pressure (BP) reduction in older women after a resistance training (RT) program. METHODS Twenty-five older women (≥60 years) performed a RT program for 8 weeks, 3x/week consisting of 3 sets of 8-12 repetitions maximum in 8 exercises. Acute and chronic BP measurements were performed using automatic equipment, in which acute BP was measured before and after 10, 20, 30, 40, 50 and 60 min following the sixth exercise session, while chronic BP was measured pre and post-training. RESULTS Significant decrease for systolic blood pressure (SBP) was observed after the intervention period, however, the diastolic blood pressure (DBP) did not change. To acute changes in BP, SBP decreased at all times after a single RT session, while DBP increased after 40 min. The reduction for SBP after a single RT session at baseline showed positive and significant correlations with the reductions in basal SBP observed after the 8 weeks of RT, the strongest correlations were observed at 20 min. A linear relationship between the magnitude of change in chronic SBP and the 20 min for acute SBP, and 30 min for acute DBP of post-exercise was observed. CONCLUSION The results suggest that acute BP lowering after RT session is a reliable predictor of chronic BP response to exercise training, and 20 min of resting, after RT training, is enough to indicate chronic response of BP as this measure was highly associated with chronic BP lowering in older women.

https://doi.org/10.1590/s1980-6574201800010005 1968 downloads

11.

Accuracy of chest radiography for positioning of the umbilical venous catheter
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Guimarães, Adriana F.M.

; Souza, Aline A.C.G. de

; Bouzada, Maria Cândida F.

; Meira, Zilda M.A.

Jornal de Pediatria

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apr 2017, Volume 93 N. 2 Pages 172 - 178

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: Avaliar a acurácia da análise simultânea dos três marcos anatômicos radiográficos - diafragma, silhueta cardíaca e corpos vertebrais - na determinação da posição da extremidade distal do cateter venoso umbilical com a ecocardiografia como padrão de referência. Métodos: Estudo transversal, observacional, com inclusão prospectiva de dados de todos os neonatos nascidos em uma maternidade pública de referência, entre abril de 2012 e setembro de 2013, submetidos à inserção de cateter venoso umbilical como parte do atendimento clínico. A posição da extremidade distal do cateter, determinada pela análise simultânea dos três marcos anatômicos radiográficos, foi comparada com a posição anatômica obtida pela ecocardiografia. Sensibilidade, especificidade, valor preditivo positivo, valor preditivo negativo e acurácia foram calculados. Resultados: Dos 162 recém-nascidos avaliados por ecocardiografia, somente 44 (27,16%) estavam com o cateter em posição ótima, na porção torácica da veia cava inferior ou na junção da veia cava inferior com o átrio direito. Os cateteres foram localizados no átrio esquerdo e no septo interatrial em 54 (33,33%), no átrio direito em 26 (16,05%), no intra-hepático em 37 (22,84%) e na aorta em um recém-nascido (0,62%). A sensibilidade, especificidade e acurácia da radiografia para detectar cateter na zona-alvo foram de 56%, 71% e 67,28%, respectivamente. Conclusão: A radiografia anteroposterior de tórax isolada não é capaz de definir com segurança a posição do cateter venoso umbilical. A ecocardiografia permite a visibilização direta da ponta do cateter em relação às estruturas vasculares e, sempre que possível, deve ser considerada para localização do cateter venoso umbilical.

Abstract Objectives: To evaluate the accuracy of the simultaneous analysis of three radiographic anatomical landmarks - diaphragm, cardiac silhouette, and vertebral bodies - in determining the position of the umbilical venous catheter distal end using echocardiography as a reference standard. Methods: This was a cross-sectional, observational study, with the prospective inclusion of data from all neonates born in a public reference hospital, between April 2012 and September 2013, submitted to umbilical venous catheter insertion as part of their medical care. The position of the catheter distal end, determined by the simultaneous analysis of three radiographic anatomical landmarks, was compared with the anatomical position obtained by echocardiography; sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated. Results: Of the 162 newborns assessed by echocardiography, only 44 (27.16%) had the catheter in optimal position, in the thoracic portion of the inferior vena cava or at the junction of the inferior vena cava with the right atrium. The catheters were located in the left atrium and interatrial septum in 54 (33.33%) newborns, in the right atrium in 26 (16.05%), intra-hepatic in 37 (22.84%), and intra-aortic in-one newborn (0.62%). The sensitivity, specificity and accuracy of the radiography to detect the catheter in the target area were 56%, 71%, and 67.28%, respectively. Conclusion: Anteroposterior radiography of the chest alone is not able to safely define the umbilical venous catheter position. Echocardiography allows direct visualization of the catheter tip in relation to vascular structures and, whenever possible, should be considered to identify the location of the umbilical venous catheter.

https://doi.org/10.1016/j.jped.2016.05.004 5100 downloads

12.

Influência de diferentes protocolos de contenção nosvalores do eletrocardiograma de macacos-da-noite (Aotus azarae infulatus)
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Chaves, Rosa H.F.

; Souza, Nazaré F.

; Muniz, José A.P.C.

; Imbeloni, Aline A.

; Neves, Ana C.S.

; K.C.Teixeira, Renan

Pesquisa Veterinária Brasileira

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feb 2017, Volume 37 N. 2 Pages 156 - 159

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Macacos-da-noite são muito susceptíveis ao estresse e por isso a contenção química ou física deve ser cuidadosamente avaliada antes de qualquer procedimento. Protocolos anestésicos podem alterar alguns parâmetros fisiológicos, sendo o eletrocardiograma (ECG) um exame muito utilizado para avaliação do ritmo e da frequência cardíaca. O objetivo deste estudo foi avaliar a influência de quatro diferentes protocolos de contenção sobre o ECG realizado em Aotus azarae infulatus. Para isso foram utilizados 10 animais, machos, adultos, submetidos à contenção com a associação tiletamina/zolazepam (TZ), isoflurano (ISO), associação cetamina e midazolam (CET) e contenção física (CF). Não foram observadas diferenças nos parâmetros de ondas e complexos obtidos no ECG em todos os grupos testados, no entanto, durante a avaliação do traçado os animais do grupo CF apresentaram uma quantidade maior de alterações. Concluiu-se que os protocolos de contenção utilizados não alteraram os valores do ECG e que não foi possível considerar o grupo CF como controle devido causar mais alterações do que todos os protocolos testados.

ABSTRACT: Feline night monkeys are very susceptible to stress and therefore the physical or chemical restraint should be carefully evaluated before any procedure. Anesthetic protocols can alter some physiological parameters, and electrocardiogram (ECG) is a commonly exam used for evaluation of the rhythm and heart rate. The objective of this study was to evaluate the influence of four different protocols of restraining on ECG in Aotus azarae infulatus, in order to identify the best method of restraining in these primates. For that, we used 10 adult feline night monkeys, males, submitted to restraining protocols with the association tiletamine and zolazepam - (TZ), isoflurane (ISO), association ketamine and midazolam (CET) and physical restraint (CF). No differences were observed in the parameters wave and ECG complexes obtained in all groups tested; however, during the evaluation of the trace the animals of group CF showed a greater amount of change. It was concluded that the restraint protocols used did not change the values of the ECG, and it was not possible to consider the CF group as control due to more caused alterations than all other tested protocols.

https://doi.org/10.1590/s0100-736x2017000200010 1338 downloads

13.

Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae
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Lima, Ana L.A.

; Alves, Adriano F.

; Xavier, Aline L.

; Mozzini-Monteiro, Talissa

; Oliveira, Theresa R.R.

; Leite, Fagner C.

; Matias, Wemerson N.

; Branco, Marianna V.S.C.

; Souza, Maria F.V.

; Piuvezam, Marcia R.

Revista Brasileira de Farmacognosia

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apr 2016, Volume 26 N. 2 Pages 225 - 232

Abstract: En | Text: En | PDF: En

ABSTRACT Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treated with hydroalcoholic extract of H. tiubae (2000 mg/kg) and analyzed by consumption of water and food, body weight, mortality and rates of major organ weights, as well as biochemical and hematological indexes. For anti-inflammatory effect, phlogistic agents such as carrageenan or acetic acid were used to evaluate paw edema, cell migration and cytokine production. It was also investigated the hydroalcoholic extract of H. tiubae in RAW 264.7 macrophage lineage by nitric oxide and cytokine productions. Swiss mice treated with hydroalcoholic extract of H. tiubae showed low toxicity and (50 or 100 mg/kg) was able to reduce significantly (p < 0.01, p < 0.001) polymorphonuclear cell migration, TNF-α and IL-1β production in the carrageenan-induced peritonitis. However the hydroalcoholic extract of H. tiubae (50, 100 or 200 mg/kg) did not reduce carrageenan-induced paw edema. Additionally, hydroalcoholic extract of H. tiubae did not present cytotoxicity at concentrations of 6.25, 12.5, 25 or 50 µg/ml but induced significantly decrease of NO, TNF-α and IL-6 production in macrophage lineage. This study suggests that hydroalcoholic extract of H. tiubae has anti-inflammatory activity by inhibiting cell migration mainly by decreasing the inflammatory cytokine levels at the inflamed site independently of the anti-edematogenic effect.

https://doi.org/10.1016/j.bjp.2015.11.001 1701 downloads

14.

Performance in the 6-minute walk test and postoperative pulmonary complications in pulmonary surgery: an observational study
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Santos, Bruna F. A.

; Souza, Hugo C. D.

; Miranda, Aline P. B.

; Cipriano, Federico G.

; Gastaldi, Ada C.

Brazilian Journal of Physical Therapy

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feb 2016, Volume 20 N. 1 Pages 66 - 72

Abstract: En | Text: En | PDF: En

OBJECTIVES: To assess functional capacity in the preoperative phase of pulmonary surgery by comparing predicted and obtained values for the six-minute walk test (6MWT) in patients with and without postoperative pulmonary complication (PPC) METHOD: Twenty-one patients in the preoperative phase of open thoracotomy were evaluated using the 6MWT, followed by monitoring of the postoperative evolution of each participant who underwent the routine treatment. Participants were then divided into two groups: the group with PPC and the group without PPC. The results were also compared with the predicted values using reference equations for the 6MWT RESULTS: Over half (57.14%) of patients developed PPC. The 6MWT was associated with the odds for PPC (odds ratio=22, p=0.01); the group without PPC in the postoperative period walked 422.38 (SD=72.18) meters during the 6MWT, while the group with PPC walked an average of 340.89 (SD=100.93) meters (p=0.02). The distance traveled by the group without PPC was 80% of the predicted value, whereas the group with PPC averaged less than 70% (p=0.03), with more appropriate predicted values for the reference equations CONCLUSIONS: The 6MWT is an easy, safe, and feasible test for routine preoperative evaluation in pulmonary surgery and may indicate patients with a higher chance of developing PPC.

https://doi.org/10.1590/bjpt-rbf.2014.0119 1470 downloads

15.

Sonda de tdr para a estimativa de umidade em bagaço de Cana-de-açúcar
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Souza, Claudinei F.

; Cirilo, Lucas da S

; Bastos, Reinaldo G.

; Peres, José G.

; Oliveira, Aline F.

Engenharia Agrícola

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feb 2016, Volume 36 N. 1 Pages 24 - 35

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O bagaço de cana-de-açúcar pode ser utilizado como suporte sólido para cultivo de microrganismos, e apesar de fundamental, o monitoramento da umidade em tempo real nesses processos ainda é pouco pesquisado. Sendo assim, o presente trabalho teve como objetivo propor e validar a TDR para estimar a umidade em bagaço de cana-de-açúcar, visando a seu uso como suporte para cultivo em estado sólido, considerando a produção de ácido cítrico. A sonda de TDR proposta foi analisada fisicamente, e, posteriormente, para a validação dos resultados, realizou-se uma calibração com leituras da constante dielétrica do bagaço de cana-de-açúcar até à saturação do material, os quais foram comparados com o método-padrão e equação universal de Topp. Também, foram conduzidas em colunas de leito fixo preenchidas com bagaço a 80% de umidade, com monitoramento da umidade através de sonda de TDR para validar a técnica. Pôde-se verificar que existe viabilidade no uso da técnica da TDR para estimar a umidade volumétrica, e com o auxílio de ferramentas gráficas e regressão linear, foi proposta a equação de calibração: (θ= 0,0253*Ka - 0,0025). Com isso, pode-se controlar e monitorar in situ a umidade do bagaço de cana-de-açúcar, através da técnica da TDR.

ABSTRACT Bagasse sugarcane can be used as a solid substrate for microorganism cultivation. Despite fundamental, moisture real-time monitoring of these processes is still poorly investigated. Thus, this study aimed at developing and validating a TDR probe to estimate moisture in sugarcane bagasse, which is used as cultivation mean of microorganisms considering citric acid production. The proposed probe was physically evaluated and then used to validate the results. Calibration readings of the bagasse dielectric constant were taken up to its saturation, and subsequently compared to standard method and Topp's universal equation. In addition, we carried out studies in fixed-bed columns filled with bagasse at 80% moisture, monitoring its moisture through TDR probe, so we could validate the technique. We concluded such technique feasibility to estimate water content. Furthermore, we proposed a calibration equation using graphical tools and linear regression (θ = 0.0253 * Ka - 0.0025). As a result, we could then control and monitor bagasse sugarcane moisture in situ by the TDR technique.

https://doi.org/10.1590/1809-4430-Eng.Agric.v36n1p24-35/2016 1352 downloads

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