Resumo: Introdução: Neste artigo, é relatada a experiência de um médico especialista em Medicina de Família e Comunidade, que trabalha em uma unidade básica de saúde da região sul do município de São Paulo, na atenção primária à saúde do Sistema Único de Saúde, ao se tornar preceptor de estudantes de Medicina da Universidade São Caetano do Sul. Método: Os estudantes conheceram a estrutura típica de uma unidade básica de saúde e treinaram a confecção da entrevista médica, sob supervisão, e do exame físico, à medida que adquiriam as competências necessárias. Treinaram ainda o pedido de exames complementares. Com isso aprenderam na prática a aplicar o método clínico. Os estudantes também treinaram a competência de aplicar o método clínico em ambientes não controlados por meio da visita domiciliar, o que lhes permitiu também conhecer a realidade do paciente in loco. Por meio do acompanhamento de famílias e de casos-índice realizado durante alguns anos, os estudantes puderam conhecer os diferentes ciclos de atendimento da Estratégia Saúde da Família, inclusive a questão da morte, que se inicia no contexto sociofamiliar. Os discentes também atuaram em grupos de orientação e transmissão de conhecimento para a comunidade e puderam treinar a comunicação e a adaptação referentes à população atendida. Participaram de reuniões de equipe, nas quais vivenciaram o planejamento semanal das atividades, a discussão interdisciplinar de casos mais complexos e as estratégias criadas. Resultados: Obtiveram-se resultados promissores com o uso das metodologias ativas que se baseiam na autonomia do estudante ante o processo de aprendizagem. Essas metodologias são aplicadas ao ensino da Medicina em ambientes de prática clínica, pois o contato com a realidade melhora o aprendizado, desafia o aluno a pesquisar com autonomia a fim de entender com clareza o que fazer com os objetivos de aprendizagem estabelecidos, ensina a usar experiências pregressas para inter-relacionar novos conhecimentos com os conhecimentos prévios, por meio da Medicina Baseada em Evidências, e refletir sobre a prática médica. Conclusão: De acordo com as Diretrizes Nacionais Curriculares, a inserção do estudante de Medicina no âmbito do Sistema Único de Saúde é imprescindível para que ele possa adquirir os conhecimentos necessários para atuar sobretudo na atenção primária à saúde.

Abstract: Introduction: This article reports the experience of a physician, specialist in Family and Community Medicine, who works in a Basic Health Unit in the southern region of the city of São Paulo, in the Primary Health Care of the Unified Health System, when he became a Preceptor of Medical students at Universidade São Caetano do Sul. Method: The students learned about the typical structure of a Basic Health Unit. They learned how to acquire the medical history during anamnesis, under supervision, and the physical examination, as they acquired the necessary skills. They also learned how to request complementary examinations. With this training, they learned how to apply the clinical method during practice. The students also learned the competence to apply the clinical method in uncontrolled environments through the home visit, which also made it possible to know the reality of the patient in loco. The follow-up of families and the index cases for a few years gave the students the opportunity to experience the different care cycles of the Family Health Strategy, including the question of death, which started in the socio-family context. They also participated and carried out assistance and knowledge transmission groups for the community, in which students were able to train communication and adaptation at the population level. They met and participated in the team meetings, which allowed showing the weekly planning of activities, the interdisciplinary discussion of more complex cases and the created strategies. Results: The promising results of the Active Methodologies based on student autonomy, in relation to the learning process, are applied to the teaching of Medicine in clinical practice environments, since the contact with reality improves learning, challenges the students to research and reflect with autonomy to think about what they must do with the established learning goals and teaches them to use previous experiences to interrelate new knowledge with previous information through Evidence-Based Medicine and reflect on medical practice. Conclusion: Comments are also made on the National Curricular Guidelines, which request the inclusion of the medical student within the scope of the Unified Health System, aimed mainly at Primary Health Care learning.

One of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC50 values ranging from 1.7 to 15.2 µg mL-1), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds.

OBJETIVO: Analisar os padrões histopatológicos das artérias do leito placentário em gestações complicadas por hipertensão arterial crônica (HAC) comparando-os com o de grávidas normais. MÉTODOS: Biópsias de leito placentário, segundo técnica de Robertson et al.¹, foram realizadas em pacientes com idade gestacional igual ou superior a 28 semanas, submetidas a cesárea, após a dequitação. O grupo controle (GC) foi composto por 25 pacientes normais e o grupo de estudo composto por 13 pacientes com HAC leve (HL), 11 pacientes com HAC moderada (HM) e 11 pacientes com HAC grave (HG). As classes de hipertensão foram consideradas leve (PAD 90 |- 100 mmHg), moderada (PAD 100 |- 110 mmHg) e grave (PAD³ > 110mmHg). Os padrões histológicos das artérias espiraladas foram classificados em: padrão inalterado, modificações fisiológicas, desorganização da camada média, alterações hiperplásicas, necrose e aterose aguda. RESULTADOS: 1) Os achados anormais foram predominantes no grupo de hipertensas, sendo mais freqüente nos grupos HM e HG. 2) O achado anormal mais prevalente foi a desorganização da camada média, com distribuição semelhante nos grupos HM e HG. 3) Os padrões normais ocorreram nos grupos GC e HL, com distribuição semelhante entre si.

OBJECTIVES: To analyze histopathological patterns of placental bed arteries in pregnancies complicated by chronic arterial hypertension. Alterations were considered according to clinical classification of the hypertensive disorders as mild (MG); moderate (MoG) and severe (SG) for comparison with uncomplicated pregnancies, control group (CG). METHODS: Placental bed biopsy was performed in 60 pregnant women; the study group was comprised of pregnant women with hypertension, subdivided in 13 with severe chronic hypertension (CH), 11 with moderate CH and 11 with mild CH, and results were compared to 25 placental bed biopsies from uncomplicated pregnancies. All the pregnant women had a gestational age of at least 28 weeks of gestation with a live fetus and were submitted to cesarean section. Hypertension was considered mild with diastolic blood pressure (DBP) 90 I? 100 mmHg, moderate DBP 100 I? 110 mmHg and severe DBP = 110 mmHg. Placental bed variables selected for histological analysis were: unaltered patterns, physiological changes, medial layer disorganization, medial and intimal hyperplasic changes, acute necrosis and atherosis. RESULTS: In cases with SG and MoG there was predominance of abnormal histophysiological findings: medial layer disorganization and hyperplasic changes, with a statistically significant difference when compared to MG and CG. Alteration in the medial layer was observed in these cases. The normal pattern, unaltered patterns and physiologic changes were more frequent in CG and MG. Physiological changes were the most usual finding, further, there was no acute necrosis or atherosis. CONCLUSION: 1. Abnormal histophysiological findings were predominant in hypertensive pregnant women compared to the normotensive ones; 2. These patterns were more frequent, according to the severity of the hypertensive disorders: Severe, Moderate and Mild; 3. More significant abnormal findings were a change in the medial layer, mainly in the group with severe hypertensive disorders; 4. The groups with moderate and severe hypertensive disorders when compared had similar results; 5. The normal histological pattern was higher in the control group and patients with mild hypertensive disorders and disclosed a similarity between them 6. The most usual pattern was physiologic changes, which was more frequent in the control group.