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Objective: To test the hypothesis that genetic variations of cannabinoid receptors contribute to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic association case-control study, cannabinoid receptor polymorphisms CNR1 rs12720071 and CNR2 rs2229579 were tested for association with neurocognitive performance in 69 patients with schizophrenia and 45 healthy controls. Neurocognition was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS). Results: We found a consistent association between CNR1 rs12720071 polymorphism and the cognitive performance of patients in several cognitive domains. Patients with C/C polymorphism presented significantly worse performance in motor speed, verbal fluency, attention/processing speed and reasoning/problem solving. Conclusion: Although limited, our data support the hypothesis that CNR1 variations may be associated with the pathogenesis of cognitive deficits of schizophrenia.

https://doi.org/10.1590/1516-4446-2020-1650

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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dec 2021, Volume 36 N. 6 Pages 725 - 735

Abstract: En | Text: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

SÍNTESE E AVALIAÇÃO DAS ATIVIDADES FOTOPROTETORA, CITOTÓXICA E ANTIVIRAL CONTRA O ZIKA VÍRUS DE DERIVADOS TRIAZÓLICOS DA BENZOFENONA
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Lima, Ângela M. A.

; Teixeira, Róbson R.

; Silva, Bianca F. da

; Siqueira, Raoni P.

; Silva, Ítalo E. P. da

; Santos, Edjon G.

; Fernandes, Maria Cecília

; Gonçalves, Victor Hugo Sousa

; Bressan, Gustavo C.

; Mendes, Tiago Antonio de Oliveira

; Paula, Sérgio O. de

; Costa, Adílson Vidal

; Santos, Marcelo H. dos

Química Nova

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may 2019, Volume 42 N. 5 Pages 473 - 484

Abstract: Pt | Text: Pt | PDF: Pt

The benzophenones are synthetic and natural compounds presenting a variety of activities, including photoprotective, cytotoxic and antiviral. It is herein described the preparation of a series of twenty-seven benzophenone derivatives bearing 1,2,3-triazole functionalities and the evaluation of their photoprotective, cytotoxic and antiviral on Zika Virus (ZIKV) activities. The compounds were prepared in three steps, namely reduction of benzophenone, alkylation of diphenylmethanol and CuAAC reactions. The in vitro evaluation of the photoprotective activity revealed that the most active derivative 4-((benzhydryloxy)methyl)-1-(4-nitrobenzyl)-1H-1,2,3-triazole (4k) displayed UVB sun protection factor equal to 6,9±0,53, which make this compound a possible candidate to be used in formulations for photoprotective applications. In terms of cytotoxicity, the compounds were evaluated against MDA-MB-231 and B16F10 cell lines. It was observed that the compounds were more active against MDA-MB-231 cells and three of them were capable of reducing cell viability by approximately 55% at 100 µmol L-1. In the antiviral screening against ZIKV, compound 4-(3-benzhydryloxy)propyl)-1-(3-methylbenzyl)-1H-1,2,3-triazole (5j) was the most effective in mantaining Vero cell viability.

https://doi.org/10.21577/0100-4042.20170365 1170 downloads

Disability as a determinant of fatigue in MS patients
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Taveira, Fernanda M.

; Braz, Nayara F. T.

; Comini-Frota, Elizabeth R.

; Teixeira, Antônio L.

; Domingues, Renan B.

Arquivos de Neuro-Psiquiatria

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apr 2019, Volume 77 N. 4 Pages 248 - 253

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A fadiga é um dos sintomas mais frequentes e incapacitantes na esclerose múltipla (EM). Fatores centrais, psicológicos e periféricos podem contribuir para a ocorrência de fadiga. Objetivos: O presente estudo teve como objetivo avaliar potenciais determinantes de fadiga em pacientes com EM remitente-recorrente (EMRR) com baixo nível de incapacidade funcional. Métodos: Foram comparados marcadores inflamatórios, pressões respiratórias, incapacidade e qualidade de vida em 39 pacientes com EMRR com e sem fadiga. Resultados: Pacientes com EMRR com fadiga apresentaram maior Escala de Incapacidade Funcional Expandida (p = 0,002). Observamos uma associação significativa entre os resultados da Escala de Incapacidade Neurológica de Guy e Escala de Avaliação da Qualidade de Vida Funcional com a presença de fadiga (valores de p < 0,05). Conclusão: O grau de comprometimento funcional, mas não a função respiratória e os marcadores inflamatórios, são determinantes para a presença de fadiga em pacientes com EM.

ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.

https://doi.org/10.1590/0004-282x20190035 2884 downloads

Diagnóstico em psicanálise: da estrutura ao discurso
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Moreira, Isa Gontijo

; Teixeira, Antônio M. R.

Revista Latinoamericana de Psicopatologia Fundamental

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dec 2018, Volume 21 N. 4 Pages 739 - 760

Cet article propose une investigation sur la problématique du diagnostic différentiel dans la pratique clinique orientée par la psychanalyse. Il s'agit d'une recherche élaborée à partir de la constatation observée dans la clinique, qui se réfère à l'opérationnalité du diagnostic phénoménologique ou structurel, d'une perspective dans laquelle l'orientation du maniement clinique ne se soumet pas à des rigueurs classificatoires préétablies, mais, effectivement, elle passe par la question du sujet dans sa relation à l'Autre, sa position dans le discours.

This paper proposes an investigation regarding the issue of the differential diagnosis in the context of the psychoanalytic practice. It consists of a research based on a clinical observation that refers to the operability of the structural diagnoses. It points out to a perspective in which the direction of the clinical management is not pervaded by the pre-established classificatory rigor, but by the issue of the subject in his relation with the Other, his discursive position.

Dieser Artikel beschreibt eine Forschungsarbeit zum Thema der Differentialdiagnose im Kontext der Praxis der psychoanalytischen Beratung. Es handelt sich um eine auf einer klinischen Bewertung beruhende Forschungsarbeit, welche die Durchführbarkeit der strukturellen Diagnose untersucht, ein Hinweis auf eine Perspektive, in der die klinische Praxis nicht auf eine vorgegebene klassifikatorische Strenge, sondern faktisch auf die Frage nach dem Subjekt in seiner Beziehung zum Anderen, seiner Position im Diskurs, beruht.

O presente artigo propõe uma investigação acerca da questão do diagnóstico diferencial no contexto da prática de orientação psicanalítica. Trata-se de uma pesquisa traçada diante de uma constatação clínica que se refere à operacionalidade do diagnóstico estrutural, um apontamento de uma perspectiva na qual a orientação do manejo clínico perpassa não pelo rigor classificatório preestabelecido, mas factualmente pela questão do sujeito em sua relação com o Outro, sua posição de discurso.

El presente artículo propone una investigación sobre la cuestión del diagnóstico diferencial en el contexto de la práctica de orientación psicoanalítica. Se trata de una investigación trazada frente a una constatación clínica que se refiere a la operatividad del diagnóstico estructural, una observación de una perspectiva en la cual la orientación del manejo clínico no está impregnada por el rigor clasificatorio preestablecido, sino por la cuestión del sujeto en su relación con el Otro, su posición de discurso.

https://doi.org/10.1590/1415-4714.2018v21n4p739.4 3717 downloads

Psychopathological evaluation and use of the Hospital Anxiety and Depression Scale in a sample of Brazilian patients with post-stroke depression
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Pedroso, Vinicius S. P.

; Vieira, Érica L. M.

; Brunoni, André R.

; Lauterbach, Edward C.

; Teixeira, Antônio L.

Archives of Clinical Psychiatry (São Paulo)

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dec 2016, Volume 43 N. 6 Pages 147 - 150

Abstract: En | Text: En | PDF: En

Abstract Background: Depression is the most frequent psychiatric complication of stroke and is often undetected or inadequately treated. Objective: This study aimed to characterize psychopathological aspects of Brazilian patients admitted to an acute stroke unit, and to evaluate the performance of the Hospital Anxiety and Depression Scale (HADS) in detecting cases of depression. Methods: This was a cross-sectional study. Sixty consecutive patients admitted to an acute stroke unit were assessed with the National Institutes of Health Stroke Scale, the Modified Rankin Scale, the Functional Independence Measure, the Mini International Neuropsychiatric Interview-Plus, the HADS, the Mini Mental State Examination (MMSE) and the Pathological Laughing and Crying Scale. Results: Prevalence of depression was 26.7%. Patients with post-stroke depression were more likely to present diabetes (p < 0.01) and had greater disability (p < 0.001) and cognitive impairment (p < 0.001) in comparison to non-depressed patients. Depressed patients showed worse performance specifically on tasks of attention/calculation and language of the MMSE. ROC curve analysis of HADS provided a cutoff value of 6 for detecting depression (sensitivity: 83.3%; specificity: 83.3%). The depression subscale of HADS (HADS-D) presented sensitivity of 100% and specificity of 99.17%. Discussion: HADS-D showed good performance in screening for depressive symptoms after acute stroke.

https://doi.org/10.1590/0101-60830000000102 1642 downloads

Sistema de preparo do solo e sua influência na atividade microbiana
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Dadalto, Juliana P.

; Fernandes, Haroldo C.

; Teixeira, Mauri M.

; Cecon, Paulo R.

; Matos, Antonio T. de

Engenharia Agrícola

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jun 2015, Volume 35 N. 3 Pages 506 - 513

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O sistema de preparo mecanizado do solo influencia diretamente sobre as propriedades físicas e biológicas do solo, além de propiciar ambiente adequado para o estabelecimento das culturas. O preparo do solo pode interferir na atividade microbiológica. Dessa forma, objetivou-se com o presente trabalho avaliar como os sistemas de preparo mecanizado do solo podem afetar sua atividade microbiológica. Os tratamentos foram os seguintes tipos de preparo do solo: plantio direto (PD), plantio convencional (PC) e cultivo mínimo (CM). Todas as análises foram feitas em três instantes: antes do preparo do solo, depois do preparo e 14 dias após o preparo do solo. Os tratamentos foram dispostos no delineamento em blocos casualizados, com quatro blocos. As coletas foram realizadas em triplicata, em duas faixas: 0,0 a 0,10 m e de 0,10 a 0,20 m de profundidade. Foram determinados o carbono orgânico total (COT), o carbono da biomassa microbiana (CBM), a respiração basal do solo (RBS), o quociente metabólico (qCO2) e o quociente microbiano (qMic). O plantio direto apresentou maiores índices de carbono da biomassa microbiana e da respiração basal do solo, na faixa de 0,0 - 0,10 m de profundidade. O plantio direto foi o sistema que apresentou menor interferência da atividade microbiológica do solo.

In addition to provide appropriate environment for crops, mechanized tillage directly affects physical and biological soil properties; besides influencing microbial activity. Therefore, we aimed at assessing how different mechanized tillage systems may affect soil microbiological activities. Treatments consisted of the following soil tillage types: No-tillage (PD), conventional tillage (PC) and minimum tillage (CM). Treatments were arranged in a randomized block design. All analyses were performed at three moments: before and after soil preparation and 14 days after tillage. Collections were made in triplicate at two soil depths (0-0.10 m and 0.10 – 0.20 m). It was determined values of total organic carbon (COT), microbial biomass carbon (CBM), basal soil respiration (RBS), metabolic quotient (qCO2) and microbial quotient (qMic). No-tillage system showed higher ratios of microbial biomass carbon and soil basal respiration at 0.0 – 0.10 m depth. Therefore, no till was the system that had greater microbial activity in the soil.

https://doi.org/10.1590/1809-4430-Eng.Agric.v35n3p506-513/2015 7966 downloads

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis
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Barichello, Tatiana

; Fagundes, Glauco D.

; Generoso, Jaqueline S.

; Dagostin, Caroline S.

; Simões, Lutiana R.

; Vilela, Márcia C.

; Comim, Clarissa M.

; Petronilho, Fabricia

; Quevedo, João

; Teixeira, Antonio L.

Brazilian Journal of Psychiatry

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dec 2014, Volume 36 N. 4 Pages 322 - 329

Abstract: En | Text: En | PDF: En

Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups: control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis. Results: The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF. Conclusions: The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis.

https://doi.org/10.1590/1516-4446-2014-1443 1965 downloads

10.

Do hematologic constituents really increase due to endurance exercise in horses?
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Teixeira-Neto, Antonio R.

; Ferraz, Guilherme C.

; Moscardini, Augusto R.C.

; Albernaz, Raquel M.

; Gondin, Milena R.

; Queiroz-Neto, Antonio

Pesquisa Veterinária Brasileira

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sep 2012, Volume 32 N. 9 Pages 951 - 956

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo objetivou avaliar o comportamento dos componentes do sangue em cavalos que concluiram com êxito provas de enduro em condições tropicais. Punção da veia jugular foi realizada para coletar o sangue antes, durante e após o evento. Os dados foram analisados por meio de uma abordagem matemática, com base no hematócrito e volume de sangue onde a variação percentual no volume plasmático foi utilizada para corrigir os valores de cada variável analisada. O nível de significância adotado foi P<0,05. O modelo matemático proposto para avaliar as concentrações de componentes do sangue permitiu a observação de um padrão diferente no comportamento de várias variáveis plasmáticas, destacando que a abordagem seguida pelos autores é mais sensível do que aquelas que não seguiram este procedimento. Em conclusão, o método utilizado neste estudo permitiu acompanhar os processos fisiológicos que realmente ocorrem durante o esforço de resistência em condições tropicais.

The aim of this study was to evaluate the behavior of blood constituents in a group of horses that successfully completed long endurance rides in tropical conditions. Jugular vein puncture was done to collect blood before, during and after rides. Data were analyzed using a mathematic approach, based on the hematocrit and blood volume where the percentual change in plasma volume was used to correct the values of each variable analyzed. Significance was inferred when P<0.05. The proposed mathematical model to assess blood constituents concentrations allowed the observation of a different pattern of the variables behavior, pointing out that the approach followed by the authors could be more sensitive than ones that did not take this routine. In conclusion, the method used in this study enabled to monitor the physiological processes that actually occur during endurance effort in tropical conditions.

2160 downloads

11.

As bodas sintomáticas do obsessivo com a histérica
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Teixeira, Antônio M. R.

Ágora: Estudos em Teoria Psicanalítica

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jun 2010, Volume 13 N. 1 Pages 51 - 61

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Ao considerar o sofrimento gerado pelas relações amorosas como causa de demanda terapêutica, na clínica psicanalítica, procurou-se interrogar aqui em que sentido o parceiro sexual pode vir a constituir um sintoma para o sujeito. No encaminhamento dessa questão, examinou-se, mais especificamente, o modo de parceria sintomática entre sujeitos obsessivos e histéricos, apoiando-se na teoria psicanalítica do parceiro sintoma. Procura-se demonstrar de que maneira os sujeitos histéricos e obsessivos respondem, no nível dessa parceria, aos impasses engendrados pela ausência de inscrição simbólica da relação sexual.

The symptomatic wedding of the obsessive with the hysterical. When considering the suffering produced by loving relationships as the cause of therapeutic demand in the psychoanalytic clinic, we try to discuss the way in which a sexual partner can become a symptom to the subject. In the treatment of this issue, the author has examined, more specifically, the mode of symptomatic partnership between obsessive and hysterical subjects, relying on the psychoanalytic theory of the symptom partner. In this way, the article shows how obsessive and hysterical subjects respond, at the level of this partnership, to the impasses related by the absence of the symbolic inscription of the sexual report.

27658 downloads

12.

Hipotireoidismo adquirido tratado como obesidade exógena: a importância do controle do crescimento
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Zambon, Mariana Porto

; Antonio, Maria Ângela R. G. M.

; Mendes, Roberto Teixeira

; B. Filho, Antônio de Azevedo

Revista Paulista de Pediatria

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mar 2009, Volume 27 N. 1 Pages 106 - 109

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Demonstrar a importância da interpretação do acompanhamento pôndero-estatural de crianças e adolescentes obesos DESCRIÇÃO DO CASO: Menina de 12 anos e 11 meses encaminhada a um ambulatório terciário para acompanhamento de obesidade e dislipidemia. Referia ganho de peso a partir de oito anos, negava fazer atividade física e possuía alimentação adequada. Relatava obesidade na família do pai. Ao exame, bom estado geral, diminuição da pilificação e mixedema generalizados, pele ressecada e áspera. Peso com percentil entre 90 e 97, índice de massa corpórea (IMC) acima do percentil 97 e estatura abaixo do canal de crescimento. EXAMES LABORATORIAIS: T4: 0,04ng/ dL, TSH: >100uUI/mL, colesterol total: 326mg/ dL, HDL colesterol: 34mg/ dL, LDL colesterol: 45mg/ dL, triglicérides: 1599mg/ dL, glicemia em jejum: 81mg/dL e hemograma com discreta anemia normocrômica e normocítica. Fez-se o diagnóstico de hipotireoidismo e introduziu-se hormônio tireoidiano com boa resposta. A paciente trouxe 23 medidas prévias de peso e estatura, mostrando comprometimento de estatura e aumento de peso não valorizado. COMENTÁRIOS: A análise dos gráficos de crescimento é fundamental para o acompanhamento de todas as crianças e adolescentes, principalmente aquelas com sobrepeso e obesidade. A desaceleração da curva de crescimento em altura sugere doença associada; neste caso, o hipotireoidismo adquirido.

OBJECTIVE: To show the value of using the follow-up growth charts in clinical evaluation of obese children and adolescents. CASE DESCRIPTION: A 12 years and 11 months-old girl referred to a tertiary out-patient clinic to evaluate obesity and lipid abnormalities. She had weight gain since eight years old, had no physical activity and followed adequate eating habits. Obesity was referred in father's family. In physical examination, she looked well, with lack of body hair, generalized mixedema, dry and rough skin. Weight was between percentile 90 and 97; BMI was over the percentile 97 and height was under the growth channel. LABORATORY EXAMS: T4: 0.04ng/dL, TSH: >100uUI/mL, total cholesterol: 326mg/dL, HDL cholesterol: 34mg/ dL, LDL cholesterol: 45mg/dL, triglycerides: 1599mg/dL, fasting glicose: 81mg/dL and hemogram with normocromic and normocytic anemia. Hypothyroidism diagnosis was made and thyroid hormone was introduced with good response. The patient brought 23 previous heights and weight measurements, which showed height drop and weight gain in the growth chart, all of them undervalued. COMMENTS: Growth chart analysis is important for the follow-up of children and adolescents, especially those with overweight and obesity. The linear growth slowing suggests an associated sickness; in this case, an acquired hypothyroidism.

9594 downloads

13.

Environment, interactions between Trypanosoma cruzi and its host, and health
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Teixeira, Antonio R. L.

; Gomes, Clever

; Lozzi, Silene P.

; Hecht, Mariana M.

; Rosa, Ana de Cássia

; Monteiro, Pedro S.

; Bussacos, Ana Carolina

; Nitz, Nadjar

; McManus, Concepta

Cadernos de Saúde Pública

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2009, Volume 25 Suppl. 1 Pages S32 - S44

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Uma rede epidemiológica envolvendo o Trypanosoma cruzi foi discutida nos níveis ambientais e de interações moleculares nos hospedeiros que habitam em 19 diferentes ecossistemas. O protozoário tem uma enorme plasticidade controlada geneticamente que confere sua adaptação a cerca de quarenta espécies de triatomíneos e mais de mil espécies de mamíferos. Essas infecções estão profundamente embutidas em inúmeros ecótopos, onde elas estão inacessíveis aos métodos de controle utilizados. Muito mais estudos de campo e de laboratório são necessários à obtenção de dados e informação pertinentes ao controle e prevenção das infecções pelo Tr. cruzi e as várias manifestações da doença. Ênfase deve ser dada àquelas interações que ocorrem nos níveis celulares e ambientais que se poderiam tomar como alvos seletivos para prevenção da doença. Novas tecnologias para mobilização social devem ser disponibilizadas para os que trabalham pela justiça e pela igualdade, mediante informação para a promoção da saúde. Um programa direcionado de educação de massa pode prover informação e comunicação necessárias para proteger os habitantes atualmente expostos ao risco de contrair as infecções pelo Tr. cruzi.

An epidemiological chain involving Trypanosoma cruzi is discussed at the environmental level, and in terms of fine molecular interactions in invertebrate and vertebrate hosts dwelling in different ecosystems. This protozoan has a complex, genetically controlled plasticity, which confers adaptation to approximately 40 blood-sucking triatomine species and to over 1,000 mammalian species, fulfilling diverse metabolic requirements in its complex life-cycle. The Tr. cruzi infections are deeply embedded in countless ecotypes, where they are difficult to defeat using the control methods that are currently available. Many more field and laboratory studies are required to obtain data and information that may be used for the control and prevention of Tr. cruzi infections and their various disease manifestations. Emphasis should be placed on those sensitive interactions at cellular and environmental levels that could become selected targets for disease prevention. In the short term, new technologies for social mobilization should be used by people and organizations working for justice and equality through health information and promotion. A mass media directed program could deliver education, information and communication to protect the inhabitants at risk of contracting Tr. cruzi infections.

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14.

Environment, interactions between Trypanosoma cruzi and its host, and health
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Teixeira, Antonio R. L.

; Gomes, Clever

; Lozzi, Silene P.

; Hecht, Mariana M.

; Rosa, Ana de Cássia

; Monteiro, Pedro S.

; Bussacos, Ana Carolina

; Nitz, Nadjar

; McManus, Concepta

Cadernos de Saúde Pública

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2009, Volume 25 Suppl. 1 Pages S32 - S44

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

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Crianças e adolescentes obesos: dois anos de acompanhamento interdisciplinar
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Zambon, Mariana Porto

; Antonio, Maria Ângela R. G. M.

; Mendes, Roberto Teixeira

; Barros Filho, Antônio de Azevedo

Revista Paulista de Pediatria

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jun 2008, Volume 26 N. 2 Pages 130 - 135

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar dois anos de seguimento de crianças e adolescentes obesos em ambulatório especializado. MÉTODOS: Trata-se de coorte, com coleta retrospectiva dos dados de 150 pacientes (1 a 19 anos de idade) do Ambulatório de Obesidade do Hospital de Clínicas da Universidade Estadual de Campinas. Destes pacientes, 53% eram do sexo masculino e 63% eram de Campinas, São Paulo. A média da idade no início de ganho de peso foi 4,3 anos. Dos 150 pacientes, 128 retornaram uma vez, com avaliação de peso, altura, índice de massa corpórea (IMC) e escores Z. Foram realizados hemograma, glicemia de jejum, insulina basal, relação glicemia/insulina, triglicérides, colesterol total e frações. Os pacientes foram divididos em dois grupos, de acordo com o seguimento. Entre os grupos, foi analisada a diferença entre idade, sexo, procedência, idade de início, acantose nigricans e os escores Z de peso, altura e IMC, proporção de exames laboratoriais alterados e a diferença dos escores Z de IMC em relação à primeira consulta. RESULTADOS: Dos 128 pacientes, 57% permaneceram em seguimento, sendo que 114 retornaram pelo menos uma vez. Comparando os grupos, os moradores de Campinas foram os que mais abandonaram o ambulatório, sem diferenças em relação às demais variáveis clínicas, antropométricas e laboratoriais estudadas. Houve queda da média do escore Z do IMC em ambos os grupos, em relação à consulta inicial. CONCLUSÕES: Os pacientes deste estudo apresentaram redução da média do escore Z do IMC semelhante à literatura. Apesar do alto índice de abandono, não foram identificados fatores de risco que o justificassem, com exceção da procedência da criança.

OBJECTIVE: To study two years follow-up of obese children and adolescents from a specialized out-patient clinic. METHODS: This cohort study with retrospective collection of data enrolled 150 patients (1 to 19 years old, 53% males, 63% from Campinas, São Paulo, Brazil, and at mean age of 4.3 years when they started the weight gain). All patients were followed at the Obesity Out-Patient Clinic of the Clinical Hospital of Campinas University. Out of the 150 patients, 128 returned once and weight, height, body mass index (BMI) measurements and Z scores were obtained. Laboratory exams were colleted: hemoglobin, lipids, fasting glucose and fasting insulin. Glucose/insulin ratio was calculated. Patients were divided in two groups, if they returned or not to the clinic. Difference between both groups were analyzed regarding age, gender, city of origin, age when the weight gain started, acanthosis nigricans, weight, height, BMI Z score and proportion of altered laboratory exams. The difference in BMI Z score in relation to the first visit was also analyzed. RESULTS: Among the 128 patients, 57% continued to be followed in the clinic and 114 returned at least once. Comparing groups, patients from Campinas fail more to return. There were no differences in the clinical, anthropometric and laboratory variables. Both groups showed lower mean BMI Z score in the return visit compared to the first visit. CONCLUSIONS: The obese children and adolescents from the follow-up clinic showed a reduction in the mean BMI Z score similar to published data. The rate of dropping follow-up was high, but no variable could explain it, except for the patient origin.

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