ABSTRACT African mahogany (Khaya grandifoliola) is a forest species with excellent wood quality. Due to the increasing demand for viable seeds in forest production programs, the storage capacity of this species must be evaluated. Therefore, this study aimed to determine the appropriate environmental and packaging conditions for the storage of African mahogany seeds. Initially, the water content of the seeds, germination rate, and seedling length were determined in two environments (cold chamber and laboratory), two packages (polyethylene and glass), and three storage periods (72, 144, and 216 d) as well as in additional treatment without storage. The variables analyzed during storage were water content, germination capacity, germination speed index, and seedling length. The experiment was conducted in a completely random design with four repetitions in a split-plot scheme and an additional treatment of 2 × 3 × 2 + 1. African mahogany seeds stored in a cold chamber (6 °C and 72% relative humidity) in a polyethylene packaging maintained their physiological quality for 216 d.

RESUMO O mogno africano (Khaya grandifoliola) é uma espécie florestal que apresenta excelente qualidade madeireira. Com a crescente demanda por sementes viáveis para atender programas de produção florestal, tem-se observado a necessidade de estudos sobre a capacidade de armazenamento dessa espécie. O objetivo deste trabalho foi determinar as condições adequadas de ambiente e embalagem para o armazenamento de sementes de mogno africano. Inicialmente, o grau de umidade das sementes; a germinação e o comprimento de plântulas foram determinados. Foram testados dois ambientes - câmara fria e laboratório; duas embalagens (polietileno e vidro); e três períodos de armazenamento (72, 144 e 216 dias). As variáveis analisadas no armazenamento foram: grau de umidade, porcentagem de germinação, índice de velocidade de germinação (IVG) e comprimento de plântulas. O experimento foi realizado em delineamento inteiramente casualizado com quatro repetições em parcelas subdivididas e tratamento adicional 2 × 3 × 2 + 1. As sementes de mogno africano armazenadas em ambiente de câmara fria (6 °C e 72% UR) em embalagem de polietileno mantiveram a qualidade fisiológica por 216 dias.

ABSTRACT Given the recalcitrant nature of peach palm seeds, which results in high sensitivity to desiccation, more effective approaches to seed quality monitoring are extremely important and justify the need to provide an efficient method to determine their moisture content. For seeds which are considered to be larger (thousand seed weight > 200 g), seed preparation is required, but it is impractical owing to endocarp hardness. The objective of this work was to compare methods of evaluating the moisture content of peach palm seeds, aiming to identify an straightforward method for the species. Different seed preparation and drying methods (oven method at 105 ± 3 °C, low temperature at 103 ± 2 °C, and high temperature at 130 ± 2 °C) were tested. For all methods tested, the beginning of weighing took place after the first hour, and continued until the mass of each repetition became constant for two consecutive measurements. The data were analyzed by nonlinear quadratic plateau regression to evaluate the stabilization period of water content. Thus, the oven method at 130 °C for four hours (with whole seeds) is recommended.

RESUMO O comportamento altamente recalcitrante das sementes de pupunheira justifica a adequação de um método eficiente para determinação do seu teor de água, uma vez que estas são sensíveis à dessecação. Visto que as sementes de pupunha são consideradas grandes (peso de mil sementes > 200 g) os métodos atuais de determinação do teor de água exigem preparo das sementes, o que é inviabilizado devido a resistência do endocarpo. O objetivo deste trabalho foi comparar diferentes métodos de determinação do teor de água de sementes de pupunheira, visando identificar o mais eficiente para a espécie. Foram testadas diferentes formas de preparo da semente e métodos de secagem. Para todos os tratamentos testados, o início da pesagem ocorreu após a primeira hora, continuando até que a massa de cada repetição se tornasse constante por duas medidas consecutivas. Os dados foram analisados por uma regressão não linear quadrática em platô para avaliar o período de estabilização do teor de água. Assim, o método de estufa a 130 ºC durante quatro horas (com sementes inteiras) é recomendado.

ABSTRACT: The species Pinus taeda is largely used in intensive silviculture worldwide. This species has propagation through seeds, which requires determining seeds viability for their commercialization. The germination test recommended for this species usually requires up to 63 days to provide results on the quality of freshly harvested seeds, delaying commercialization and favoring contamination during the conduction of the test. The authors of this study aimed to establish the developmental stages of P. taeda seedlings to determine a criterion for interpreting the germination test with greater speed and efficiency to obtain results. The seeds were sown in transparent plastic boxes on two sheets of blotting paper and placed in a germinator at 22 °C with constant lighting. Five morphological stages of seedling development were defined with daily counts of the number of normal seedlings for each criterion, distribution in time, and the accumulated percentage of normal seedlings adjusted to time-to-event nonlinear regression. The new interpretation criterion proposed in this study is efficient, and P. taeda seedlings can be considered normal when cotyledon leaves differ by approximately 3 mm between the integument and hypocotyl, reducing the time to conduct the germination test by up to ten days compared to the criterion usually used in the routine analysis of seed laboratories.

Resumo: Cordia trichotoma (Vell.) Arrab. ex Steud. é uma espécie florestal nativa do Brasil, propagada naturalmente por sementes, cuja avaliação da qualidade pode estar sendo subestimada pela utilização de métodos não adequados para condução do teste de germinação. Diante do potencial de utilização desta planta e da importância de se conservar espécies nativas, o presente trabalho teve por objetivo definir as condições mais adequadas para condução do teste de germinação em sementes de louro-pardo, durante três anos consecutivos de avaliações. Para tanto, foram testados: temperaturas (20, 25 e 30 °C) e substratos (papel mata-borrão, papel filtro, areia e vermiculita) em sementes coletadas em diferentes safras. Os testes foram excecutados sob delineamento experimental inteiramente casualizado, com quatro repetições, em esquema fatorial (temperaturas x substratos), sendo os dados obtidos submetidos à análise de variância e as médias comparadas pelo teste de Tukey (p ≤ 0,05). Foram determinados a porcentagem e o índice de velocidade de germinação, além da análise de sanidade das sementes. Conclui-se que o teste de germinação para sementes de louro-pardo deve ser conduzido entre vermiculita, a 30 °C, sem fornecimento de luz, sendo a primeira contagem realizada aos 26 dias e a última aos 48 dias após a instalação do teste.

Abstract: Cordia trichotoma (Vell.) Arrab. ex Steud. is a forest species native to Brazil, naturally propagated by seeds, whose quality assessment may be underestimated by the use of inappropriate methods for conducting the germination test. Given the potential use of this plant and the importance of conserving native species, the present work aimed to study parameters for conducting the germination test in louro-pardo seeds, during three consecutive years of evaluations. For this purpose, temperatures (20, 25 and 30 °C) and substrates (blotter paper, filter paper, sand and vermiculite) were tested in seeds collected in different crop seasons. The tests were carried out under a completely randomized experimental design, with four replications, in a factorial scheme for the germination test (temperatures x substrates), with the data obtained being subjected to analysis of variance and means compared by Tukey’s test (p ≤ 0.05). Germination percentage and speed index were determined, and seed health analysis was performed. It is concluded that the germination test for louro-pardo seeds should be carried out between vermiculite, at 30 °C, without light supply, with the first count carried out at 26 days and the last count at 48 days after setting up the test.

We investigated the effect of Punica granatum peel aqueous extract (PGE), on pulmonary inflammation and alveolar degradation induced by intratracheal administration of Elastase in Sprague Dawley rats. Lung inflammation was induced in rats by intratracheal instillation of Elastase. On day 1 and 2, animals received an intraperitoneal injection of PGE (200 mg/mL), three hours later, they were intratracheally instilled with 25U/kg pancreatic porcine Elastase. Animals were sacrificed 7 days later. Bronchoalveolar lavage (BAL) were collected and cellularity, histology and mRNA expression of Monocyte chemotactic protein 1(MCP-1), Tumor Necrosis Factor-Alpha (TNF-α), Interleukin 6 (IL-6), and Matrix Metalloproteinase-2 (MMP-2) were studied. In addition, activity of TNF- α, IL-6 and MCP-1 on BAL were also analyzed by ELISA Kit. Elastase administration increased: BAL cellularity, neutrophils recruitment and BAL MCP1, IL-6 expressions. It also increased lung TNF-α, MCP-1, MMP-2 expressions, platelets recruitment, histological parameters at 7th day of elastase treatment. Intraperitoneal injection of 200 mg/kg of PGE reduced, significantly, BAL cellularity, and neutrophils recruitment. However, in animal treated with PGE, MCP-1, MMP-2 and IL-6 on day 7, were similar to the Sham group. Treatment with PGE (200 mg/ kg) also significantly reduced lung TNF-α, and MCP-1 expression. This study reveals that PGE Punica granatum protects against elastase lung inflammation and alveolar degradation induced in rats.

ABSTRACT Eucalyptus cloeziana is one of the highest-density wood species offering significant added value, frequently used in the construction and furniture industries. Despite its suitability, it may be overlooked on account of its propagation difficulties due either to its low rooting cutting capacity or to its seeds having a low germination rate perhaps attributable to the high proportion of indistinguishable impurities within the seed lots. This study aimed to develop an efficient technique for Eucalyptus cloeziana seed processing to increase the physical purity and, consequently, the physiological quality of the seed lot. Three seed lots, separated by size in sieves with 1.18, 1.00, and 0.84 mm square openings, were used. X-ray analyses were carried out, the number of normal seedlings and germination rate identified and the percentage and speed of seedling emergence under greenhouse conditions ascertained. The greenhouse evaluation showed that the seed retained in the 1.18 mm sieve presented viability and vigor twice that of the control. Therefore, the processing technique by size classification is efficient in terms of improving the physical and physiological performance of Eucalyptus cloeziana seed lots.

RESUMO: Para comercialização das sementes de Bactris gasipaes Kunth, é necessária a realização do teste de germinação, cuja metodologia já se encontra estabelecida e tem duração de 120 dias. Em função do comportamento recalcitrante, a semente possui curta longevidade no armazenamento, em geral 30 a 45 dias, o que dificulta a seleção de sementes viáveis para a comercialização. O trabalho teve por objetivo estabelecer uma metodologia para condução do teste de tetrazólio em sementes de pupunha para obter resultados rápidos e que possam ser relacionados com o teste de germinação. Foram realizadas avaliações do teor de água, teste de germinação e teste de tetrazólio, considerando-se diferentes formas de pré-condicionamento, preparo e coloração, as áreas vitais da semente e estabelecendo as classes de viabilidade. O teste de tetrazólio, em função dos resultados obtidos para o lote estudado, forneceu resultados correlacionados ao teste de germinação mediante sua condução com pré-condicionamento por imersão em água (20 °C por 24 h), corte longitudinal adjacente ao embrião e imersão de metade da semente (embrião + endosperma) em solução a 1,0%, por 4 h a 30 °C. Assim, foi possível separar as sementes de pupunha em duas classes (viáveis e não viáveis).

ABSTRACT: Prior to commercialization, seeds of peach palm (Bactris gasipaes Kunth) have to undergo the germination test, whose well-established methodology takes 120 days. Due to their recalcitrant behavior, the seeds have short longevity when stored (around 30-45 days), which makes it challenging to select the most viable ones for marketing. This study aimed to determine a methodology for the tetrazolium test to be carried out in peach palm seeds, in order to fast deliver results that can be correlated to the germination test. Different forms of pre-conditioning, preparation, and staining were investigated via moisture content, germination, and tetrazolium tests, so as to define the vital parts of the seed and sort out the viability classes. For the seed lot under study, the tetrazolium test delivered results supported by the germination test when the following procedures were adopted: pre-conditioning by water submersion (20 °C for 24 h), longitudinal cut adjacent to the embryo, and half-seed immersion (embryo + endosperm) in a 1.0% tetrazolium solution for 4 h at 30 °C. Having fulfilled these criteria, it became possible to separate the peach palm seeds into two classes (viable or non-viable).

Agriculture plays a vital role in the South African economy, as well as in the production of maize for food. Genetically modified maize is transformed to encode for crystalline (Cry) proteins found in Bacillus thuringiensis (Bt) and is referred to as Bt maize. Ingestion of specific Cry proteins causes the death of target insects that cause harm to maize plants. Bt crops, along with herbicides such as glyphosate and 2,4-dichlorophenoxyacetic acid (2,4-D), are widely adopted as part of the South African farming regime that aims to increase crop yield and reduce costs of production. As chemical compounds used in agriculture often end up in water sources, their presence should be monitored. There are many such monitoring programmes worldwide, but not in South Africa. We screened surface water sources in a maize-dominated agricultural area in the North West Province in South Africa for the presence of Cry1Ab, glyphosate and 2,4-D using enzyme-linked immunosorbent assays (ELISAs). Cry1Ab was not detected at any site; glyphosate was below the limit of detection at most of the sites but one sample had quantifiable traces of glyphosate; and 2,4-D was detected at all the sites. The concentrations of 2,4-D exceeded those for drinking water according to European guidelines, thus highlighting the need for regular monitoring of these compounds. Many people depend on untreated water resources, which may be contaminated by toxic agricultural chemicals. This report is the first on levels of these target compounds in South African water systems.SIGNIFICANCE: •This report is the first on the presence of glyphosate, 2,4-D and Cry1Ab in the South African aquatic environment. •Concentrations of 2,4-D in South African surface waters exceed the European guideline for drinking water, indicating a risk to people using these water sources. •These preliminary results highlight the need to regularly monitor for the presence of glyphosate, 2,4-D and Cry1Ab in water resources in South Africa

RESUMO Modelos Lineares Generalizados (GLM) são uma extensão do modelo linear e englobam às distribuições normal, Poisson e binomial negativa. Apesar de terem sido introduzidos em 1972, na maioria dos estudos em tecnologia de sementes, especialmente naqueles que envolvem dados de contagem, como o teste de germinação em sementes do gênero Eucalyptus, ainda predomina a Análise de Variância, sem análise do ajuste de outros modelos. Assim, o objetivo desse trabalho foi avaliar o modelo mais adequado, na classe dos GLM, para dados de contagem de sementes de Eucalyptus cloeziana. Os dados foram obtidos a partir da realização de teste de germinação, utilizando-se sementes de três lotes de Eucalyptus cloeziana, sendo que cada lote foi separado por meio de peneiras em três frações de material, com base no seu tamanho: pequeno (<0,84 mm), médio (entre 1,18 e 1,00 mm) e grande (>1,18 mm). A análise dos dados foi fundamentada na utilização dos GLM ajustados à distribuição normal, Poisson e binomial negativa, analisando-se ajuste pelos critérios de Akaike e Bayesiano de Schwarz, pelos gráficos de diagnóstico da distância de Cook, Half-normal. O ajuste de distribuição normal diferiu na configuração de médias submetidas ao teste de Tukey em relação aos outros ajustes e, apesar dos dados atenderem todos os pressupostos de normalidade, pode-se concluir que o ajuste com a distribuição de Poisson foi o que mais se adequou aos dados de contagem do teste de germinação de sementes de E. cloeziana.

ABSTRACT Generalized linear models (GLMs) are an extension of the linear model and include the normal, Poisson, and negative binomial distributions. Although GLMs were introduced in 1972, most seed technology studies, especially those involving count data, such as germination tests of seeds from the genus Eucalyptus, still using the analysis of variance, without analysis of the fit of other models. Thus, this study aimed to evaluate the most appropriate model in the GLM class for seed count data of Eucalyptus cloeziana. Data were obtained from a germination test using seeds from three lots of E. cloeziana. Each lot was separated by sieving into three material fractions based on size: small (<0.84 mm), medium (from 1.18 to 1.00 mm), and large (>1.18 mm). The data analysis was based on the use of GLMs adjusted to normal, Poisson, and negative binomial distributions, and the models were evaluated by the Akaike and Bayesian Schwartz criteria and Cook’s distance and half-normal diagnostic graphs. Compared to other adjustments, the normal distribution adjustment differed in the configuration of means submitted to the Tukey test, and although the data met all normality assumptions, the adjustment with the Poisson distribution was the most suitable for the count data from a germination test of E. cloeziana seeds.

RESUMO: O objetivo deste trabalho foi avaliar e comparar o efeito inflamatório, por meio da determinação de proteínas de fase aguda, produzido por dois protocolos cirúrgicos distintos de ovariohisterectomia em cadelas. Para tanto, foram determinadas as concentrações de proteína C reativa (CRP) e haptoglobina (Hp) de 17 cadelas, sem raça definida, adultas, sendo nove animais submetidos à ovariohisterectomia pela técnica convencional por laparotomia e oito a ovariohisterectomia pela técnica minimamente invasiva. Para avaliar a resposta de fase aguda causada pelo trauma cirúrgico, amostras de sangue foram obtidas antes dos procedimentos cirúrgicos e em quatro momentos distintos após as cirurgias (24, 48 horas e sete dias) para as dosagens de CRP e Hp, com kit comercial ELISA e via ensaio de ligação com a hemoglobina, respectivamente, validados para o uso em cães. Como não houve distribuição normal dos dados, utilizou-se o teste de Kruskall-Wallis para comparação das variáveis quantitativas entre os dois grupos. Os testes de Friedman e One-way ANOVA foram usados para comparações múltiplas entre os momentos avaliados, sendo considerado P<0,05 como significante. Houve diferença significativa (P<0,0001) para as concentrações de CRP 24 horas após o procedimento cirúrgico entre os dois protocolos utilizados. Não houve diferença significativa para as concentrações de Hp entre os dois protocolos cirúrgicos. Foram evidenciadas alterações significativas para as concentrações de CRP e Hp 24 e 48 horas após as ovariohisterectomias, independentemente da técnica cirúrgica utilizada. As concentrações de CRP e Hp demonstraram o efeito inflamatório imediato induzido pela ovariohisterectomia convencional e minimamente invasiva.

ABSTRACT: The aim of this study was to evaluate and to compare the possible inflammatory changes by screening acute phase proteins concentrations in healthy bitches subjected to ovariohysterectomy. Minimally invasive and conventional (laparotomy) ovariohysterectomies were performed in 17 client-owned adult female mixed breed dogs. Nine animals were subjected to minimally invasive and eight animals to conventional ovariohysterectomy. Blood samples were taken before surgery, 24, 48 hours, and seven days postoperatively. Serum C-reactive concentration was determined by a commercial ELISA kit and serum haptoglobin concentration was measured via hemoglobin binding assay, both previously validated for use in dogs. As the data did not meet the normal distribution criteria, the nonparametric Kruskall-Wallis was performed to compare quantitative variables between groups. One-way ANOVA and the Friedman test were used for multiple comparisons between time points, with a P<0.05 considered significant. C-reactive protein concentration was significantly different (P<0.0001) at 24 hours postoperatively between groups. There was no significant difference in haptoglobin concentration between groups. C-reactive protein and haptoglobin concentrations were significantly different at 24 and 48 hours postoperatively for minimally invasive and conventional ovariohisterectomies. These findings provided an overview of the short-term inflammatory effects produced by minimally invasive and conventional ovariohysterectomies.

Abstract: Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually overexpressed with chemotherapy, leading to chemoresistance. OLP, a lesion with carcinogenic potency, is broadly classified into the asymptomatic reticular form and the aggressive erosive form. The objective of the study was to verify the expression level of p-glycoprotein in antifungal-treated and untreated reticular OLP, in untreated erosive OLP and erosive OLP patients treated with corticosteroid. Semi-quantitative reverse transcriptase polymerase chain reaction (SQ-RTPCR) and ELISA were performed on biopsy tissue samples to evaluate the mdr1 mRNA and protein expression of p-glycoprotein, respectively. The present study shows for the first time that mdr1 mRNA as well as its translated form p-glycoprotein are overexpressed in OLP subjects compared to healthy individuals. This overexpression is significantly higher in erosive than in reticular OLP patients, further confirming that the erosive form has higher risk for multidrug resistance. A higher expression is also observed in corticosteroid-treated erosive cases than similar untreated ones. The gradation of expression is in conformity with severity of the disease.

Abstract The literature about collaboration for innovation has reported fundamental activities performed by intermediaries. In this paper, universities' technology transfer offices (TTOs) are placed as intermediaries between academic research and the industry. Our study focuses on collaborative research and development (R&D) projects between universities and industry in order to understand the roles of TTOs throughout the whole duration of the project. The main aim of this paper is to identify the roles of TTOs throughout collaborative R&D projects and suggest some lessons for Brazilian TTOs based on the experience of the United Kingdom. Through qualitative case studies in the United Kingdom and Brazil, the analyses show that both TTOs performed critical activities for collaborative R&D projects. Similar activities at both TTOs were the management of partnerships in terms of negotiating contracts and the protection and licensing of intellectual property. Findings also show that the search for partners in the beginning of the project, the pacifier role of the TTO to help mutual understanding, and the active commercialisation of academic research to external partners happened only in the UK case, which may generate implications for TTOs in Brazil.

OBJETIVO: Descrever a atividade antimicrobiana da defensina-beta 2 na glândula mamária e secretada no leite materno humano. MÉTODOS: A produção de peptídeos foi realizada por clonagem de DNA. Os níveis de defensina-beta 2 foram quantificados em 61 amostras de colostro e 39 de leite maduro de doadoras saudáveis pelo teste ELISA indireto. Por um ensaio de halo de inibição, avaliamos a atividade contra sete isolados clínicos diarreicos de crianças entre 0 e 2 anos. A atividade da defensina 2 contra três patógenos oportunistas que podem causar infecções nosocomiais foi determinada pelo teste de microdiluição. RESULTADOS: Os níveis de peptídeos estavam significativamente maiores nas amostras de colostro (n = 61) que de leite maduro (n = 39), como segue: 8,52 (2,6-16,3 µg/mL) mediana e faixa em comparação a 0,97 (0,22-3,78), p < 0,0001; teste de Mann-Whitney. O peptídeo recombinante foi obtido da alta atividade antimicrobiana demonstrada contra uma ampla gama de bactérias patogênicas. Sua atividade antibacteriana foi demonstrada em um disco contendo entre 1-4 µg, que produziu zonas de inibição entre 18 e 30 mm contra três isolados de Salmonella spp. e quatro de E. coli. A defensina-beta 2 demonstrou concentrações inibitórias mínimas (CIMs) de 0,25 µg/mL e 0,5 µg/mL para S. marcescen and P. aeruginosa, ao passo que uma CIM maior (4 µg/mL) foi obtida contra um isolado de cepa multirresistente de A. baumannii. CONCLUSÕES: Até onde sabemos, este estudo é o primeiro a relatar níveis de defensina em mulheres da América Latina. A produção e a atividade da defensina 2 no leite materno comprovam sua importância como uma molécula de defesa para a saúde intestinal em pacientes pediátricos.

OBJECTIVE: To describe the antimicrobial activity of ß-defensin-2 produced in the mammary gland and secreted in human breast milk. METHODS: The peptide production was performed by DNA cloning. ß-defensin-2 levels were quantified in 61 colostrum samples and 39 mature milk samples from healthy donors, by an indirect enzyme-linked immunosorbent assay (ELISA). Using halo inhibition assay, this study assessed activity against seven clinical isolates from diarrheal feces of children between 0 and 2 years of age. The activity of ß-defensin-2 against three opportunistic pathogens that can cause nosocomial infections was determined by microdilution test. RESULTS: The peptide levels were higher in colostrum (n = 61) than in mature milk samples (n = 39), as follows: median and range, 8.52 (2.6-16.3) µg/ml versus 0.97 (0.22-3.78), p < 0.0001; Mann-Whitney test. The recombinant peptide obtained showed high antimicrobial activity against a broad range of pathogenic bacteria. Its antibacterial activity was demonstrated in a disk containing between 1-4 µg, which produced inhibition zones ranging from 18 to 30 mm against three isolates of Salmonella spp. and four of E. coli. ß-defensin-2 showed minimum inhibitory concentrations (MICs) of 0.25 µg/mL and 0.5 µg/mL for S. marcescen and P. aeruginosa, respectively, while a higher MIC (4 µg/mL) was obtained against an isolated of multidrug-resistant strain of A. baumannii. CONCLUSIONS: To the authors' knowledge, this study is the first to report ß-defensin-2 levels in Latin American women. The production and the activity of ß-defensin-2 in breast milk prove its importance as a defense molecule for intestinal health in pediatric patients.

Os fatores de personalidade têm sido estudados na área da Psicologia como elementos importantes relacionados à saúde de pacientes com doenças crônicas. Através de uma revisão compreensiva da literatura, o presente artigo objetiva examinar as relações entre os fatores de personalidade a partir do Modelo dos Cinco Grandes Fatores e comportamentos em saúde, em especial a adesão ao tratamento, nesses pacientes. São abordados o conceito de personalidade dentro desse modelo, bem como são discutidos estudos que relacionam a personalidade e comportamentos que facilitam a saúde. Todos os fatores de personalidade parecem exercer impacto na saúde física, contudo, percebe-se que o fator Neuroticismo tem efeitos negativos na saúde e tem sido relacionado a uma série de doenças físicas. Já a Realização parece ser o fator mais relacionado a comportamentos saudáveis em relação à saúde.

Personality factors have been studied in Psychology as important elements associated to health behaviors and adherence to medical treatments. The present paper aims at reviewing international literature regarding personality and health factors, based on the Big Five model. The concept of personality is discussed, as well as studies that examined the relationship between personality and health behaviors. All personality factors seem to have influence on individuals’ physical health; however, it is noted that the Neuroticism factor has negative effects on health. This factor has been linked to the development of a multitude of physical diseases. Yet, Conscientiousness seems to be the factor most associated with healthier behaviors.

OBJETIVOS: Identificar os principais achados fundoscópicos em pacientes portadores de anemia falciforme encaminhados a um Serviço Oftalmológico de Referência em Goiânia (GO). MÉTODOS: Foram realizados exames oftalmológicos em 50 pacientes (100 olhos) portadores de hemoglobinopatia falciforme para observar quais as alterações retinianas mais comuns nesse grupo. RESULTADOS: O tipo de hemoglobinopatia mais encontrado foi o SS, seguido pelas hemoglobinopatias SC, AS e Sthal. Dentro da amostra estudada, 22% apresentaram alterações retinianas. Destes 73% eram do sexo masculino. A alteração retinianas encontradas foram: "sea fan", "black sunburst", hemorragia vítrea e descolamento de retina. Em relação à classificação da retinopatia, 73% apresentaram a forma proliferativa, sendo vista nos tipos AS e SC e 27% apresentaram a forma não-proliferativa da retinopatia, sendo vista nos portadores do tipo SS. CONCLUSÃO: Foi observado elevado número de pacientes com alterações retinianas na amostra estudada, sendo o maior número em portadores da hemoglobinopatia SC, seguido dos grupos AS e SS. As alterações proliferativas foram as mais observadas. Hemorragia vítrea e descolamento de retina foram as manifestações proliferativas de maior prevalência e mostraram ser mais frequente em portadores da hemoglobinopatia SC na população estudada.

PURPOSE: To identify retinal manifestations in patients with sickle cell disease referred to a reference eye hospital in Goiânia (GO). METHODS: Ophthalmic evaluation was made in 50 patients (100 eyes) with sickle cell disease to evaluate the most common manifestations of this group. RESULTS: Hemoglobinopathy SS was the most commonly found, followed by hemoglobin SC, AS and Stahl. Twenty-two percent of the patients had retinal changes, of these 73% were male. Retinal changes observed were: "sea fan", "black sunburst", vitreous hemorrhage, and retinal detachment. In the classification of retinopathy, 73% had proliferative form, seen in the types AS and SC and 27% had non-proliferative retinopathy, seen in patients with SS type. CONCLUSIONS: We observed a large numbers of patients with retinal changes, most of them with hemoglobinopathy SC, followed by AS and SS groups. The proliferative changes were the most commonly observed. Vitreous hemorrhage and retinal detachment were the most prevalent manifestations in proliferative retinopathy and showed to be more common in patients with SC hemoglobinopathy in the studied population.