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Resumen Introducción: El objetivo principal del estudio fue evaluar la mortalidad en los pacientes con COVID-19 graves y críticos, que recibieron tocilizumab (TCZ) -un antagonista monoclonal del receptor de IL-6- de forma temprana vs. tardía. Métodos: Cohorte retrospectiva multicéntrica de pacientes >18 años internados con COVID-19 desde el 1/7/2021-1/8/2022, con 5-7 puntos de gravedad inicial (GI) según Escala de la OMS. Se consideró adminis tración temprana o tardía a la infusión de TCZ ≤ ó > a 48 h del ingreso. Las variables de resultado fueron mortalidad a 28 días y cambio de la GI. Los factores relacionados con la mortalidad fueron evaluados con regresión de Cox. Resultados: Se incluyeron 266 pacientes, 159(60%) varones; edad 58(± 15); con hipertensión arterial (43%), obesidad (37%) y diabetes (27%);70 presentaban GI = 5 (oxígeno suplementario), 143 GI = 6 (ventilación no inva siva o cánula nasal de alto flujo) y 53 GI = 7 (ventilación mecánica invasiva). La mortalidad a 28 días fue 42%, asociada independientemente a: edad, obesidad, GI, días entre la internación y administración del TCZ, y días entre la fecha de inicio de síntomas y el TCZ. La mortalidad para GI 5, 6 y 7 fue 26%, 39% y 72%, respectivamente; 76% y 62% de los pacientes permanecieron estables o mejoraron la GI a los días 3 y 7 de la infusión de TCZ. La mortalidad a 28 días fue 39% (TCZ temprano) vs. 57% (TCZ tardío); p = 0.02; HR = 0.63[0.41-0.99, p = 0.05]). Discusión: Estos resultados apoyan la administración temprana de TCZ en pacientes con COVID-19 grave y crítica.

Abstract Introduction: Tocilizumab (TCZ), an IL-6 receptor antagonist monoclonal antibody is warranted in severe and critically-ill COVID-19 patients. The objective was to evaluate 28-day mortality of patients with severe or critical COVID-19 treated with early vs delayed TCZ. Methods: Multicenter, retrospective cohort study in cluding patients>18 years hospitalized between 7/1/2021- 8/1/2022 with confirmed COVID-19, with 5, 6 and 7 points of WHO Ordinal Initial Severity Scale [SS]. Early or late administration was considered if TCZ was administered before or after 48 hours from admission. Outcomes were28-day mortality and change of SS. Factors related to 28-day mortality were evaluated with Cox regression. Results: 266 patients were included, 159(60%) male; aged 58(± 15); frequent comorbidities were hypertension (42%), obesity (37%) and diabetes (27%). Seventy patients had a SS = 5 (Supplemental O2), 143 had SS = 6 (NIV/ HFNC), and 53 had SS = 7 (IMV). 28-day mortality was 42%(112/266); predictors were age, obesity, higher SS, days between hospitalization and TCZ administration, and fewer days between symptoms onset and TCZ. Mortality of SS 5, 6 and 7 was 26%, 39% and 72% respectively. Com pared with baseline SS points, 76% and 62% of patients remained stable or improved on days 3 and 7 since TCZ administration. 28-day mortality was lower when TCZ was administered before 48 hours (39% vs 57%; p = 0.02; HR = 0.63;[0.41-0.99, p = 0.05]). Discussion: This study supports the early use of TCZ in patients with severe or critical COVID-19.

Revisiting the ambush bug genus Neoanthylla Kormilev, 1951 (Reduviidae, Phymatinae)
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CASTRO-HUERTAS, Valentina

; VARELA, Pablo Sebastian

; MELO, María Cecilia

Revista de la Sociedad Entomológica Argentina

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mar 2023, Volume 82 N. 1 Pages 31 - 41

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Neoanthylla (Kormilev, 1951) es un género Neotropical de Phymatinae con tres especies válidas: Neoanthylla bucki (Kormilev), Neoanthylla horvathi (Handlirsch) y Neoanthylla peruviana Kormilev. Morfológicamente se caracteriza por el profémur alargado y ovalado con la superficie cuticular lisa y brillante; las procoxas largas y subiguales al mesofémur; la carina prosternal larga, alcanzando el margen anterior del mesosternum; y el abdomen entero posteriormente. Las especies de Neoanthylla están escasamente documentadas en la literatura y las estructuras genitales son desconocidas. Además, las especies brasileñas (N. bucki y N. horvathi) son conocidas sólo por hembras. Aquí, se revisa Neoanthylla, se actualizan las diagnosis de las especies válidas, se brindan imágenes de los holotipos de N. horvathi y N. peruviana, y se describe por primera vez el macho de N. horvathi, incluyendo los caracteres genitales.

Abstract Neoanthylla (Kormilev, 1951) is a Neotropical genus of Phymatinae with three valid species: Neoanthylla bucki (Kormilev), Neoanthylla horvathi (Handlirsch), and Neoanthylla peruviana Kormilev. Morphologically, it is characterized by the elongated and oval profemur with the cuticular surface smooth and shiny; the procoxa long and subequal to the mesofemur; the prosternal carina long, reaching the anterior margin of the mesosternum; and the abdomen posteriorly entire. Neoanthylla species are scarcely documented in the literature, and the genital structures are unknown. In addition, the Brazilian species (N. bucki and N. horvathi) are known only by female specimens. Here, Neoanthylla is revisited, the diagnoses of the valid species are improved, images of the holotypes of N. horvathi and N. peruviana are provided, and the male of N. horvathi is described for the first time, including genital characters.

Trabajo decente en México: la influencia del entorno económico y la apertura al exterior
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Arredondo, Rocío N.

; Davia, María A.

; Varela, Rogelio

Problemas del desarrollo

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dec 2022, Volume 53 N. 211 Pages 29 - 53

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Este texto presenta la medición del trabajo decente en México durante el periodo 2005-2019, usando un índice multidimensional que engloba aspectos salariales (salario digno) y no salariales (derechos), al tiempo que se analiza su relación con el entorno económico y la apertura al exterior. Haciendo uso de la estructura jerárquica de la base de datos contenida en la Encuesta Nacional de Ocupación y Empleo (ENOE), se estima un modelo multinivel en el que se indica una relación positiva entre el trabajo decente, y las ramas productivas con mayor inversión extranjera directa, así como con las entidades federativas con mayor peso de las exportaciones respecto a su PIB. También se identifica la relación entre éste y la heterogeneidad en las características sociodemográficas del trabajador y aspectos relacionados con su entorno sectorial y estatal.

Abstract This article presents the measurement of decent work in Mexico during the period 2005-2019, using a multidimensional index that encompasses salary (dignified salary) and non-salary (rights) aspects, while analyzing its relationship with the economic environment and openness. Using the hierarchical structure of the database contained in the National Survey of Occupation and Employment (ENOE), a multilevel model is estimated in which a positive relationship is indicated between decent work and the productive branches with the highest direct foreign investment, as well as the states with the greatest weight of exports with respect to their GBP. Also identified is the relationship between this and the heterogeneity in the sociodemographic characteristics of the worker and aspects related to their sectoral and state environment.

https://doi.org/10.22201/iiec.20078951e.2022.211.69886

Evolution of the spontaneous sourdoughs microbiota prepared with organic or conventional whole wheat flours from South Brazil
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COSTA, LETÍCIA F.X.

; KOTHE, CAROLINE ISABEL

; GRASSOTTI, TIELA T.

; GARSKE, RAQUEL P.

; SANDOVAL, BEATRIZ N.

; VARELA, ANA PAULA M.

; PRICHULA, JANIRA

; FRAZZON, JEVERSON

; MANN, MICHELE B.

; THYS, ROBERTA C.S.

; FRAZZON, ANA PAULA G.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Suppl. 4 elocation e20220091

Abstract: En | Text: En | PDF: En

Abstract The purpose of this study was to compare the composition and stability of bacteria and fungi communities during the propagation of sourdoughs prepared with organic or conventional whole wheat (Triticum aestivum) flours from South Brazil. Sourdoughs were prepared and samples were collected during different fermentation times (0 to 216 h). Total DNA of sourdough samples were extracted and the 16S rRNA gene and Internal Transcribed Spacer region were sequenced by MiSeq-Illumina. A total of 43 and 56 OTUs were identified and defined as core taxa in the bacterial and fungal communities, respectively. The analysis revealed increases in the relative abundances of the lactic acid (Pediococcus pentosaceus, Weissella hellenica and Limosilactobacillus pontis) and acetic acid bacteria (Gluconobacter frateurii and Acetobacter tropicalis) during the sourdough propagation. The filaments fungi, Alternaria tenuissima, Fusarium culmorum, Fusarium petersiae and Microdochium seminicola remained more stable in organic than conventional during propagation cycles. After 216 h of fermentation, both sourdoughs were dominated by acid- and salt-tolerant yeast Issatchenkia orientalis (syn Pichia kudriavzevii, and Candida glycerinogenes). In conclusion, there were no significant differences in microbial communities among the sourdough samples. This study revealed that both flours contain autochthonous LAB, AAB, and yeasts with biotechnological applications in sourdough bread-making.

https://doi.org/10.1590/0001-3765202220220091

Técnica TAPP en manos jóvenes. Es posible reproducir los resultados de la técnica Lichtenstein para la hernia inguinal sintomática primaria unilateral
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Cubas, Santiago

; Varela, Martín

; Brito, María N.

; Pouy, Andrés

; Muniz, Nicolás D.

; Parada, Ulises

; Haro, Camila

; Almada, Mario

; Martínez, Marysol

; Canessa, César E.

Revista argentina de cirugía

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dec 2021, Volume 113 N. 4 Pages 434 - 443

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Background: Inguinal hernia repair is one of the most common procedures in general surgery. Each year, 20 million surgeries for inguinal hernia repaired are performed; the most common techniques used are the Lichtenstein procedure and the transabdominal preperitoneal (TAPP) laparoscopic approach. Objective: The aim of the present study is to evaluate the outcomes of the TAPP approach performed by residents and young surgeons in training in a university center. TAPP was compared with the Lichtenstein and the outcomes at 30 days were compared. The variables considered were complications, postoperative pain, length of hospital stay and procedure-related costs. The long-term variables analyzed were recurrence and chronic pain. Material and methods: We conducted an observational study comparing two surgical techniques, using prospectively acquired information from the database of our department. The cohort was made up of 80 patients undergoing inguinal hernia repair in two university-based hospitals in Montevideo, Uruguay (Hospital de Clínicas and Hospital Español), between May 2015 and May 2019. The patients were divided into two groups: Lichtenstein procedure (group 1) and TAPP procedure (group 2). Results: There were no significant differences in length of hospital stay and postoperative complications. One patient in the Lichtenstein group presented hernia recurrence. Mean operative time was 20 minutes longer with laparoscopic hernia repair, and the cost of the materials was higher. Postoperative pain at 24 hours was greater in the TAPP group, but was similar at 48 hours, 7 days, one month, three months and six months in both groups. Conclusion: The use of TAPP technique for unilateral primary inguinal hernia is feasible to perform by young surgeons or surgeons in training, and the percentage of complications, postoperative pain and recurrences is similar to that of the Lichtenstein technique, although the cost of materials and operative time are slightly higher.

RESUMEN Antecedentes: La hernioplastia inguinal es el procedimiento quirúrgico más frecuentemente realizado dentro de la Cirugía General. Se realizan anualmente 20 millones de hernioplastias; la técnica de Lichtenstein y la transabdominal preperitoneal (TAPP) mediante cirugía laparoscópica son las más utilzadas. Objetivo: El objetivo del presente estudio es valorar la factibilidad de la realización del TAPP, en un centro universitario, por parte de residentes y cirujanos jóvenes en formación. Se comparó dicho procedimiento con la técnica de Lichtenstein valorando los resultados en los primeros 30 días del posoperatorio. Las principales variables para estudiar fueron: complicaciones, dolor posoperatorio, estadía hospitalaria y costo del procedimiento. Como variables para estudiar, a largo plazo, se compararon la recidiva herniaria y el dolor crónico. Material y métodos: Se realizó un estudio observacional comparando dos técnicas quirúrgicas utilizando la base de datos del Servicio con información adquirida de forma prospectiva. Se analizaron 80 pacientes, divididos en dos grupos: hernioplastia de Lichtenstein (grupo1) y hernioplastia por TAPP (grupo 2), durante el período comprendido desde mayo de 2015 hasta mayo de 2019, en dos Centros Universitarios de Montevideo Uruguay (Hospital de Clínicas y Hospital Español). Resultados: No hubo diferencia significativa en la estadía hospitalaria y complicaciones posoperatorias. El grupo del Lichtenstein presentó una recidiva herniaria. La hernioplastia laparoscópica presentó un tiempo operatorio promedio de 20 minutos más y el costo de materiales fue mayor. Si bien el dolor posoperatorio en las primeras 24 horas fue mayor en TAPP, el dolor a las 48 horas, 7días, un mes, tres meses y seis meses fue similar en ambos grupos. Conclusión: La técnica de TAPP, para la hernia inguinal primaria unilateral, es factible de ser realizada por cirujanos jóvenes o en formación, con un porcentaje de complicaciones, dolor posoperatorio y recidivas similares al Lichtenstein, aunque con un costo de materiales y tiempo operatorio levemente mayor.

https://doi.org/10.25132/raac.v113.n4.1498 17 downloads

Mapping of pathological manifestations in asphalt pavement through the use of drones
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Vasconcelos Fernandes, R. T.

; Fonseca Cabral, A.

; Batista Dantas, G. C.

; Varela Tinoco, V. N.

; Azevedo da Silveira, B. D.

; Sousa Junior, A. M.

Revista ALCONPAT

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apr 2021, Volume 11 N. 1 Pages 61 - 72

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen El objetivo de este trabajo es estudiar la viabilidad del empleo de Drones para mapear e inspeccionar manifestaciones patológicas en pavimentos asfálticos en comparación con el método tradicional. Se establecieron parcelas muestrales cada 20 m, con 6 m de extensión, totalizando 20 estaciones, las cuales tuvieron sus manifestaciones patológicas anotadas y calculado el Índice Global de Gravedad para el área de estudio. Los resultados obtenidos con las metodologías de referencia y alternativa se confrontaron en función de las patologías identificadas y el tiempo empleado en los levantamientos. Los resultados demostraron viabilidad para el empleo de Drones en la inspección de patologías de pavimentos asfálticos, tomando como base la Norma DNIT 006/2003 - PRO, obteniendo resultados similares a la metodología tradicional con reducción significativa del tiempo de operación (33,3%).

Abstract This work objective is to study the feasibility of the Drones’ use for mapping and inspecting pathological manifestations in asphalt pavements compared to the traditional method. Sampling plots were established every 20 m, with 6 m extension, making a total of 20 stations, which had their pathological manifestations recorded and calculated with the Global Severity Index for the study area. The results obtained by the reference and alternative methodologies were confronted according to the pathologies identified and the time spent in the surveys. The results showed feasibility in the use of drones for inspection of pathologies in asphalt pavements, based on DNIT 006/2003 - PRO, obtaining results similar to those of the traditional methodology with a significant reduction of the time of operation (33.3%).

Resumo Este trabalho objetiva estudar a viabilidade do emprego de Drones para mapeamento e inspeção de manifestações patológicas em pavimentos asfálticos comparando ao método tradicional. Foram estabelecidas parcelas amostrais a cada 20 m, com 6 m de extensão, totalizando 20 estações, as quais tiveram suas manifestações patológicas anotadas e calculado o Índice Global de Gravidade para a área de estudo. Os resultados obtidos pelas metodologias de referência e alternativa foram confrontados em função das patologias identificadas e do tempo gasto nos levantamentos. Os resultados demonstraram viabilidade para emprego de Drones para inspeção de patologias em pavimentos asfálticos, tomando como base a Norma DNIT 006/2003 - PRO, obtendo resultados similares à metodologia tradicional com redução significativa do tempo de operação (33,3%).

https://doi.org/10.21041/ra.v11i1.521 40 downloads

Control de los factores de riesgo cardiovascular en diabetes tipo 2 en una consulta monográfica
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Pérez-Pevida, B.

; Varela, N.

; Pérez Rodríguez, S.

; Martínez Segura, E.

; Salvador, J.

; Escalada, J.

Anales del Sistema Sanitario de Navarra

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dec 2017, Volume 40 N. 3 Pages 413 - 420

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Background. Achieving an adequate control of glycaemic and cardiovascular risk factors (CVRFs) is essential in patients with type 2 diabetes mellitus (T2DM). However, several studies have shown that the percentage of patients achieving these goals is scarce. We evaluated the degree of control of CVRFs target goals in T2DM patients who regularly attend a specialized diabetic clinic. Methods. We studied T2DM patients who attended the specialized Diabetic Unit at the Department of Endocrinology of Clínica Universidad de Navarra with a minimum follow-up of one year. Clinical characteristics, chronic complications and treatments were collected and patients were classified into groups according to the fulfilment of target glycated haemoglobin (HbA1c), LDL cholesterol and blood pressure (BP) levels, predefined according to the presence of different comorbidities and the duration of T2DM. Results. We analysed 137 patients (75% men) with T2DM, with an average age of 67 years and a 12.7 year duration of diabetes. During follow-up, 83.9% of the patients were within the individualized HbA1c target, 76.6% considering BP and 67.2% in terms of LDL-cholesterol. In addition, 68% had concomitantly the three main variables within the target. Conclusions. In our population of T2DM, HbA1c, LDL cholesterol and BP targets were achieved in a substantial proportion of patients (67-91%). Perhaps the intense and individualized care offered through a specialized diabetes unit may explain these results.

RESUMEN Fundamento. Un adecuado control de la glucemia y de los factores de riesgo cardiovascular (FRCV) es fundamental en los pacientes con diabetes mellitus tipo 2 (DM2). Sin embargo, diversos estudios han demostrado que el porcentaje de pacientes que alcanzan dichos objetivos es escaso. Hemos evaluado el grado de control de FRCV en pacientes DM2 que acuden con regularidad a una consulta monográfica de diabetes. Pacientes y métodos. Se han estudiado los pacientes con DM2 que acudían a revisión al departamento de Endocrinología de la Clínica Universidad de Navarra con un seguimiento mínimo de un año. Se presentan las características clínicas, complicaciones crónicas y tratamiento médico, así como la clasificación en grupos según el cumplimiento de los objetivos de hemoglobina glicada (HbA1c), perfil lipídico (LDL-colesterol) y presión arterial (PA) individualizados según comorbilidades y años de evolución de la DM2. Resultados. Se han analizado 137 pacientes (75% hombres) con DM2, 67 años de edad media y 12,7 años de evolución. Durante el seguimiento, se encontraron dentro del rango objetivo individualizado de HbA1c el 83,9% de los pacientes, el 67,2% en cuanto a LDL-colesterol y el 76,6% considerando PA. Además, el 68% presentaron las tres variables principales dentro del objetivo. Conclusiones. En nuestra población de DM2 la consecución de objetivos de HbA1c, LDL-colesterol y PA se alcanza en una importante proporción de pacientes (67-91%). Posiblemente la intensa e individualizada atención ofrecida a través de una unidad de diabetes especializada pueda explicar estos resultados.

https://doi.org/10.23938/assn.0089 1525 downloads

Profiling of antioxidant potential and phytoconstituents of Plantago coronopus
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Pereira, C. G.

; Custódio, L.

; Rodrigues, M. J.

; Neng, N. R.

; Nogueira, J. M. F.

; Carlier, J.

; Costa, M. C.

; Varela, J.

; Barreira, L.

Brazilian Journal of Biology

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jul 2017, Volume 77 N. 3 Pages 632 - 641

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A espécie halófita Plantago coronopus tem vários usos etnomedicinais já descritos, mas em relação à bioatividade a informação é escassa. Este trabalho efetuou, pela primeira vez, uma análise comparativa dos órgãos de P. coronopus em termos de compostos fenólicos e atividade antioxidante de extratos orgânicos e aquosos provenientes das raízes, folhas e flores da planta, bem como o conteúdo de determinados nutrientes, aminoácidos e minerais, nas folhas da planta. As raízes (extratos de acetato de etila e metanol) apresentaram a maior atividade de captação para os radicais 1,1-difenil-2-picril hidrazil (DPPH) e 2,2’-azino-bis(3-etilbenzotiazolina-6-ácido sulfónico) (ABTS), enquanto as folhas (extrato de hexano) mostraram maior atividade captadora para o radical óxido nítrico bem como maior capacidade quelante do ferro. A análise por cromatografia liquida de alta eficiência (CLAE) identificou dezoito compostos fenólicos e, destes, o ácido salicílico e a epicatequina são aqui descritos pela primeira vez em espécies de Plantago. As folhas desta planta halófita mostraram ainda conter minerais em níveis semelhantes aos da maioria dos vegetais, provando ser uma boa fonte de elementos como o cálcio, sódio, ferro e magnésio, bem como de vários dos aminoácidos essenciais o que justifica seu uso na alimentação. Os resultados, particularmente aqueles relacionados à composição fenólica, podem justificar os principais usos medicinais atribuídos a esta espécie e, na sua totalidade, demonstram o potencial de P. coronopus como fonte de moléculas bioativas particularmente úteis na prevenção de doenças relacionadas com estresse oxidativo.

Abstract The halophyte species Plantago coronopus has several described ethnomedicinal uses, but few reported biological activities. This work carried out for the first time a comparative analysis of P. coronopus organs in terms of phenolic composition and antioxidant activity of organic and water extracts from roots, leaves and flowers. The leaves contents in selected nutrients, namely amino acids and minerals, are also described. Roots (ethyl acetate and methanol extracts) had the highest radical scavenging activity (RSA) towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, while leaves (hexane extract) had higher RSA on nitric oxide radical and iron chelating ability. High performance liquid chromatography (HPLC) analysis identified eighteen phenolics from which salicylic acid and epicatechin are here firstly described in Plantago species. Leaves had mineral levels similar to those of most vegetables, proving to be a good source for elements like calcium, sodium, iron and magnesium, and also for several of the essential amino acids justifying it use as food. Our results, especially those regarding the phenolics composition, can explain the main traditional uses given to this plantain and, altogether, emphasize the potential of P. coronopus as a source of bioactive molecules particularly useful for the prevention of oxidative stress-related diseases.

https://doi.org/10.1590/1519-6984.02416 2245 downloads

Cuantificación de la fijación biológica de nitrógeno en Canavalia ensiformis crecida en un suelo pardo mullido carbonatado mediante los métodos de abundancia natural de 15N y diferencia de N total
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Martín Alonso, Gloria M

; Tamayo Aguilar, Yonger

; Hernández Forte, Ionel

; Varela Nualles, Mario

; da Silva Araujo, Ednaldo

Cultivos Tropicales

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mar 2017, Volume 38 N. 1 Pages 122 - 130

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

In this work were traced as objectives to evaluate the growth and N accumulation in Canavalia ensiformis, grown in a Cambisol soil of El Salvador municipality, county of Guantánamo, coinoculated with four isolated of Rhizobium and two strains of HMA, as well as to quantify the process of nitrogen simbiotic fixation of this species, by the methods of the natural abundance of 15N and the difference of total N. The dry mass growth and the N absorption of the jackbean sowed in monoculture were superior in presence of the isolated of Rhizobium Can 5, coinoculated with Rhizoglomus intraradices, in these plants, the BNF oscillated from 59 to 72 kg ha-1 in the dry and rainy period, respectively. The methods of BNF quantification, difference of total N and natural abundance of 15N were similar to each other, although the difference of total N overestimates the quantification values regarding the natural abundance

En el presente trabajo, se trazaron como objetivos evaluar el crecimiento y acumulación de N en Canavalia ensiformis, crecida en un suelo Pardo mullido carbonatado del municipio El Salvador, provincia Guantánamo, coinoculada con cuatro aislados de Rhizobium y dos cepas de HMA, así como cuantificar el proceso de fijación simbiótica de nitrógeno de esta especie, mediante los métodos de la abundancia natural de 15N y la diferencia de N total. El crecimiento en masa seca y la absorción de N de la canavalia sembrada en monocultivo fue superior en presencia del aislado de Rhizobium Can 5, coinoculado con Rhizoglomus intraradices, plantas que realizaron una FBN que oscila de 59 a 72 kg ha-1 en el período poco lluvioso y lluvioso, respectivamente. Los métodos de cuantificación de la FBN, por la diferencia de N total y abundancia natural de 15N fueron semejantes entre sí, aunque la diferencia de N total sobreestima los valores de cuantificación respecto a la abundancia natural

10.

No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza Vieira

; Apostolos-Pereira, Samira L.

; Arruda, Walter Oleschko

; Brooks, Joseph B. Bidin

; Cal, Henrique S. Rodrigues

; Damasceno, Carlos A. Albuquerque

; Gama, Paulo Diniz

; Goncalves, Marcus V. Magno

; Jesus, Carlos A. da Silva de

; Machado, Suzana C. Nunes

; Mansur, Letícia Fezer

; Matta, Andre P. da Cunha

; Mendes, Maria Fernanda

; Morales, Rogerio Rizo

; Nobrega-Jr, Adaucto Wanderley da

; Parolin, Monica K. Fiuza

; Peres, Mario Pietro

; Ribeiro, Marlise de Castro

; Ruocco, Heloisa Helena

; Scherpenhuijzen, Simone

; Siquinelli, Fabio

; Stoney, Patrick N.

; Varela, Daniel Lima

; Eboni, Audred Cristina Biondo

; Spessotto, Caroline Vieira

; Rocha, Elisa Teixeira da

; Lacerda, Pamela Emanuele

Arquivos de Neuro-Psiquiatria

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jan 2017, Volume 75 N. 1 Pages 3 - 8

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Vitamina D assumiu um papel central na pesquisa e tratamento da esclerose múltipla (EM). O objetivo deste estudo foi avaliar os níveis séricos de vitamina D de pacientes com EM e controles que residem em uma área tropical. Métodos: Foram analisados dados de 535 pacientes com EM e 350 indivíduos controle em 14 cidades próximas ao Trópico de Capricórnio. Resultados: O valor médio da determinação de 25-OH vitamina D foi 26,07 ± 10,27 ng/mL para controles e 28,03 ± 12,19 ng/mL para pacientes com EM. Não houve correlação entre os níveis de vitamina D e o grau de incapacidade ao longo da duração da doença. Conclusão: Pelo menos na região que cerca o Trópico de Capricórnio, os níveis séricos de vitamina D estão entre valores de 20 a 30 ng/mL tanto para controles quanto para pacientes com EM.

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

https://doi.org/10.1590/0004-282x20160173 3011 downloads

11.

Valoración de la repercusión del dolor sobre la productividad laboral: validación del cuestionario WPAI:Pain
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Varela, N.

; Guillén-Grima, F.

; Pérez-Cajaraville, J.J.

; Pérez-Hernández, C.

; Monedero, P.

Anales del Sistema Sanitario de Navarra

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apr 2016, Volume 39 N. 1 Pages 77 - 85

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Background. Health measuring instruments are essential in daily clinical practice. However, a validation process is needed in order to certify the validity and reliability of it. The aim of our study is to validate a questionnaire to assess the consequences of pain in work productivity. Methods. Based on the Work Productivity and Activity Impairment Questionnaire - General Health we have created a modified version called WPAI:Pain in order to be able to measure the consequences of pain in work productivity. The study was conducted following the usual guidelines of test validation, omitting face validity as WPAI:Pain is a modification of an existing questionnaire. Validity and reliability were calculated. Results. A total of 577 questionnaires were obtained in 2 spanish university hospitals. The questionnaire's discriminating power was verified by Mann-Whitney test. Reliability tests were realized, Cronbach's alpha was 0.896 and Guttman split-half was 0.921. Stability was evaluated with a test-retest which was significant. Construct validity was established by Pearson correlation comparing the results of the questionnaire with the pain visual analog scale, which was statistically significant for all values. Conclusions. The WPAI:Pain questionnaire is a valid instrument for measuring the consequences of pain in work productivity. It is currently the only one validated in Spanish. Major studies are needed in order to establish its universal validity.

Fundamento. Los instrumentos de medida de salud son esenciales en la actividad clínica diaria. Sin embargo, es necesario un proceso de validación para poder certificar la validez y fiabilidad de los mismos. En la actualidad no existe ninguno que permita evaluar la repercusión del dolor en la productividad laboral de los pacientes. El objetivo de nuestro estudio es validar un cuestionario para evaluar las consecuencias del dolor en dicha productividad. Método. En base al Work Productivity and Activity Impairment Questionnaire - General Health hemos creado una versión modificada denominada WPAI:Pain con el fin obtener un cuestionario que pudiera medir las consecuencias del dolor en la productividad laboral. El estudio se realizó siguiendo las pautas habituales de validación de pruebas, omitiéndose las fases de redacción y validez de contenido ya que se modificaba un cuestionario existente. Resultados. Se obtuvieron 577 cuestionarios en dos hospitales universitarios españoles. Se comprobó la capacidad discriminante del cuestionario mediante prueba de U de Mann-Whitney. Se realizaron los test de fiabilidad obteniéndose un alfa de Cronbach de 0,896 con un test de dos mitades de Guttman de 0,921. Se comprobó la estabilidad con un test-retest estadísticamente significativo. La validez de constructo se estableció mediante correlación de Pearson comparando los resultados del cuestionario con el dolor en escala visual analógica, que resultó estadísticamente significativa para todos los valores. Conclusiones. El cuestionario WPAI:Pain es un instrumento de medida válido para determinar las consecuencias del dolor en la productividad laboral de los pacientes, siendo el único validado en español. Sin embargo, se requieren estudios de mayor envergadura para poder confirmar una validez universal.

1410 downloads

12.

Uso del compost de biosólidos en la formulación de sustratos para la producción industrial de plantas de Nothofagus alpina
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Varela, Santiago

; Martínez, Abel

Bosque (Valdivia)

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2013, Volume 34 N. 3 Pages 281 - 289

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

One of the main problems in forest seedlings production is an adequate availability of substrate to guarantee the production of good quality plants; the use of certain types of substrates is not legally permitted or even generates undesirable environmental impacts. The aim of this study was to evaluate the feasibility of using composted biosolids + pumicite (1:1) as an alternative substrate for the production of containerized seedlings of Nothofagus alpina under fertigation. To obtain better seedlings quality for transplanting, a dose with a concentration of potassium higher than that included in the standard dose commonly used in our region was applied at the last stage of the fertigation cycle. Morphological, physiological and chemical (leaf nutrients) variables and quality indexes were registered in plants. Prior to hardening, plants produced in biosolids compost had higher values of total height and diameter at the base of the stem compared to plants in traditional substrate; at the end of the production, plants produced with biosolids showed higher total plant height and higher root biomass values than those shown by plants under traditional substrate. The extra dose of potassium generated greater growth in plant height compared to plants under the standard dose. Quality index values, as well as stomatal conductance values, were similar among treatments (substrate types and fertilization doses). Plants growing under the different substrates and nutritional doses had similar values in the chemical variables. The results indicate that the biosolids compost would be a feasible alternative for production of seedlings of this species. More detailed studies on the use of plus fertilizer doses should be conducted in the future combined with the use of different types of substrates, due to the improvement observed in total seedling height and some biomass components.

Uno de los principales problemas para producir plantas forestales industrialmente es disponer de sustrato de buena calidad en cantidad suficiente. El objetivo de este estudio fue evaluar la factibilidad biológica del uso del compost de biosólidos y pumicita (1:1) en la producción de plantas de Nothofagus alpina mediante fertirriego en comparación al sustrato tradicional utilizado (turba-pumicita; 1:1). Se analizaron variables morfológicas, fisiológicas, químicas (en hojas) e índices de calidad de las plantas producidas. Adicionalmente, se estudió el efecto de una dosis nutricional extra de potasio en etapa de rustificación. Previo a la rustificación, las plantas en compost de biosólidos presentaron mayores valores de altura total y diámetro a la base del tallo. Al final del ciclo productivo se mantuvo el mayor crecimiento en altura pero se diluyeron las diferencias en diámetro, y en el caso del tratamiento sin dosis extra de potasio también se comprobó un mayor incremento en biomasa de raíces. La dosis extra de fertilización generó un mayor crecimiento en altura de las plantas en comparación a la dosis estándar, no así en el diámetro de las plantas. Los valores del índice de esbeltez (indicativos de calidad de planta) fueron similares entre tratamientos al igual que los valores de conductancia estomática. Las plantas producidas bajo los diferentes tipos de sustrato y dosis nutricionales presentaron similares valores en las variables químicas analizadas. El uso de compost de biosólidos es una alternativa posible e incluso beneficiosa (acortamiento del ciclo) en la producción industrial de plantines de N. alpina.

2960 downloads Cited 2 times in SciELO

13.

Can biosolids compost improve, in the short term, native vegetation and soils fertility in burned Nothofagus pumilio forest in Patagonia, Argentina?
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Varela, Santiago A

; Gobbi, Miriam E

; Laos, Francisca

Bosque (Valdivia)

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2011, Volume 32 N. 3 Pages 267 - 278

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

In the Patagonian Andean forests, wildfires principally have an anthropic origin and constitute one of the most important disturbances. They lead to severe losses of soil fertility and vegetation; particularly compromising the regeneration of native vegetation. Organic amendments can facilitate the regeneration of vegetation, enhancing principally soil fertility conditions. Our objective was to evaluate the effects of biosolids compost application as a tool for recovering soil fertility and regenerating vegetation in burnt areas of a Nothofagus pumilio forest along two growing seasons. Considering the National Park status of the study area, low rates (2 kg m-2) of biosolids compost application were used to minimize the polluting effect of this amendment. We considered two types of microsites, with and without litter accumulation, in order to test whether biosolids application had a differential effect related to microsite type. Soil properties, composition and cover vegetation were evaluated. We concluded that biosolids compost application improved some of the physical-chemical, chemical and biological soil properties but did not contribute, over a period of almost two growing seasons, to vegetation recovery. These results confirm that organic amendment application may be used as an initial restoration strategy at microsite level in burnt N. pumilio forests related principally to a beneficial effect on soil fertility. The creation of fertility islands can be a valid restoration strategy, but mechanisms to increase the reinstallation of native vegetation should be also applied.

En los bosques andinos patagónicos los incendios de origen antrópico son uno de los principales disturbios. Estos conducen a pérdidas de fertilidad del suelo y de vegetación, y comprometen, particularmente, la regeneración de la vegetación nativa. La aplicación de enmiendas orgánicas podría facilitar la regeneración de dicha vegetación, mejorando principalmente la fertilidad del suelo. El objetivo del presente trabajo fue evaluar los efectos de la aplicación de compost de biosólidos en la recuperación de la fertilidad del suelo y la regeneración de vegetación durante dos estaciones de crecimiento en áreas quemadas de bosque de Nothofagus pumilio. Considerando el estatus de Parque Nacional del área de estudio, la aplicación de compost se realizó en dosis bajas (2 kg m-2). Se consideraron micrositios con y sin acumulación de hojarasca, en función de registrar si la aplicación de compost de biosólidos generaba efectos diferenciales por micrositio. Se evaluaron características de fertilidad del suelo, composición y cobertura de especies vegetales luego de la aplicación. El compost de biosólidos mejoró algunas características fisicoquímicas, químicas y biológicas del suelo pero no promovió la recuperación de la cubierta vegetal. Estos resultados confirman que la aplicación de enmiendas orgánicas puede ser utilizada como una estrategia de restauración a nivel de micrositio en bosques quemados de N. pumilio, relacionada principalmente con un efecto benéfico en la fertilidad del suelo. La creación de islas de fertilidad puede ser una estrategia de restauración de la vegetación, si se asegura la aplicación de mecanismos para incrementar la reinstalación de especies vegetales nativas.

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14.

Remoção de matéria orgânica e sólidos suspensos por nova configuração de biofiltro aeróbio submerso no pós-tratamento de efluente de reator UASB
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Giustina, Saulo Varela Della

; Miranda, Luis Alcides Schiavo

; Monteggia, Luiz Olinto

Engenharia Sanitaria e Ambiental

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sep 2010, Volume 15 N. 3 Pages 257 - 266

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O pós-tratamento de efluentes de reatores anaeróbios é um processo necessário para o atendimento dos padrões de emissão. Os resultados aqui apresentados mostram a viabilidade de uso de uma nova configuração de biofiltro aeróbio submerso (BAS) no pós-tratamento desses efluentes. Os BAS multiestágio apresentam uma câmara anaeróbia (V=12,6L), seguido de uma câmara aeróbia (V=30L) e uma câmara anóxica (V=26,4L), todas em série (V total=70L). Neste estudo, foi analisada a remoção de sólidos suspensos (SS), DQO e DBO5. Foram utilizados três BAS multi-estágio preenchidos com três diferentes materiais-suporte: tampas e gargalos PET (165m²/m³), pedra britada n. 4 (50m²/m³) e anéis Pall 1,5'' (135m²/m³). Os reatores foram operados com valores de tempos de detenção hidráulicas (TDH) de 4,1, 8,2 e 12,3 horas, e três taxas de aplicação superficial (TAS) (21, 12 e 8m³/m².d). A associação dos reatores UASB+BAS possibilitou remoções de DQO total superiores a 90% para os BAS 1 e 3, e 85% para o BAS 2, sendo independente do TDH aplicado. A remoção de SS foi maior no BAS contendo anéis Pall, provavelmente devido ao maior índice de vazios desse material.

The post-treatment of effluents from anaerobic reactors is normally a mandatory step to meet the emission standards. The results presented here show the feasibility of using a new configuration of biological aerated filter (BAF) in the post-treatment of UASB reactors. The multi-stage BAF presents an anaerobic chamber (V=12.6L), followed by an aerobic chamber (V=30L) and an anoxic chamber (V=26.4L), all in series (total V=70L). This study examined the removal of suspended solids (SS), COD and BOD5. Three multi-stage BAF filled with three different packing materials were used: lids and bottlenecks of PET bottles (165m²/m³), gravel n. 4 (50m²/m³) and Pall rings 1.5'' (135m²/m³). The reactors were operated with the values of hydraulic detention time (HDT) of 4.1, 8.2 and 12.3 hours, and three superficial application rates (21, 12 and 8m³/m².d). COD removal efficiencies of 90% for BAF 1 and 3, and 85% for BAF 2 were obtained, being the removal independent of the HDT applied to BAF. The removal of SS was higher in BAF containing Pall rings, probably due to the higher voidage of this material.

11367 downloads Cited 1 time in SciELO

15.

Resultados del uso de la técnica de Mitrofanoff en pacientes con disfunción neurógena de la vejiga: Análisis de la experiencia en el Hospital Universitario San Vicente de Paul
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Arango Rave, María E.

; Lince Varela, Luis F.

; Salazar Sanín, Catalina

; Hoyos Figueroa, Francisco C.

; Hurtado, Sara N.

; Rendón Isaza, Juan C.

Actas Urológicas Españolas

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jan 2009, Volume 33 N. 1 Pages 69 - 75

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction: The care for children with neurogenic bladder, should be integral, multidisciplinary look to preserve renal function and to accomplish urinary and fecal continence, achieving that the patient becomes self-sufficient and useful to society. Methods: The result of the use of the Mitrofanoff technique for the treatment of patients with neurogenic dysfunction bladder used in the HUSVP 1998- 2003, and the current condition of the patients with respect to their illness and treatment are described in this article. A descriptive retrospective study 1998- 2002 and a prospective study during 2003 were done, in which a series of cases were analyzed. Results: 41 patients had surgery. Average age 10.2 years; average follow-up time 27.2 months; the most frequent illness was myelomeningocele (46.3%) and 46.3% had dysinergic bladder. Bladder augmentation was performed on 63.3%, of which 71.4% were constructed with ileum. A surgical intervention of the bladder neck was done on 51.2%. A continent conduct (Mitrofanoff) was performed on 95.1% of the patients with complete continence 70.4%, complete incontinence 14.6% and occasional incontinence 14.6%. 31.7% had Malone surgery with adequate fecal management on 90.2%. 19% of the stomas presented stenosis and 21.9% presented urine leakage. 80% reached appropriate social adaptation. Conclusions: The continent catheterizable stomas are useful for the treatment of urinary and fecal incontinence. The conducts constructed with ileum had more complications than the conducts done with cecal appendix, which is why the appendix is the choice tissue to perform the continent catheterizable stomas, as long as it is available.

Introducción: El cuidado de los niños con vejiga neurogénica, debe ser integral, multidisciplinario y busca preservar la función renal, alcanzar continencia urinaria y fecal, logrando que el paciente sea una persona autosuficiente y útil a la sociedad. Métodos: Describimos el resultado del uso de la técnica de Mitrofanoff en el manejo de pacientes con disfunción vesical neurógena, utilizada en el HUSVP desde 1998 al 2003, y las condiciones actuales de los pacientes con respecto a su enfermedad y tratamiento. Se realizó un estudio observacional descriptivo, retrospectivo 1998-2002 y prospectivo durante el 2003, analizando una serie de casos. Resultados: Fueron intervenidos 41 pacientes con vejiga neurogénica. Edad promedio 10.2 años; seguimiento promedio 27,2 meses; enfermedad de base más frecuente mielomeningocele (46,3%); vejiga disinérgica en 46,3%, esfínter hipotónico en 41,5%. Se realizo aumento vesical al 68,3%, utilizándose ileon en 71,4%, y alguna intervención sobre el cuello vesical al 51,2%. Se hizo una derivación tipo Mitrofanoff al 95,1% con continencia completa en 70,8%, incontinencia completa en 14.6% e incontinencia ocasional en 14,6%. En 31,7% se realizó un Malone con adecuada continencia fecal en 90,2%. De los estomas el 19% presentaron estenosis y el 21,9% presentaron escape de orina. Se encuentran socialmente adaptados 80% de los pacientes. Conclusiones: Los estomas continentes cateterizables son útiles para tratar la incontinencia urinaria y fecal. Los conductos realizados con ileon tuvieron mayores complicaciones que los elaborados con apéndice, por lo cual el apéndice debe ser el tejido de elección para realizar las derivaciones, cuando esté disponible.

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