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au:VARGAS, ANTONIO PEDRO

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The burden of physical inactivity for the public health care system in Brazil
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Prodel, Eliza

; Mrejen, Matías

; Mira, Pedro Augusto de Carvalho

; Britto, Jorge

; Vargas, Marco Antonio

; Nobrega, Antonio Claudio Lucas

Revista de Saúde Pública

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2023, Volume 57 elocation 37

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE To update the estimated cost of physical inactivity for the Brazilian Unified Health System (SUS). METHODS The hospitalization costs were accessed via a database of the Ministry of Health – Informatics Department of the Brazilian SUS. Physical inactivity for the year 2017 was accessed via the Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel – Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey). Seven chronic non-communicable diseases (NCD) were selected via the international classification of disease (ICD-10). The population fraction attributable to physical inactivity was calculated based on relative risk reported in previous studies and the prevalence of physical inactivity. RESULTS In 2017, the seven NCD considered in the analysis were responsible for 154,017 hospital admissions in adults older than 40 years old, residing in the state capitals and the Federal District, which corresponded to 6.5% of hospitalizations and 10.6% of SUS costs at an estimated US$ 112,524,914.47. Considering the group of individuals with insufficient physical activity in their leisure time, the percentage cost attributed to physical inactivity reached 17.4% of the estimated costs with NCD. At a national level, NCD were responsible for approximately 740 thousand hospitalizations, costing US$ 482 million, from which 17.4%, US$ 83 million were attributed to physical inactivity. CONCLUSION This study provides evidence to conclude that physical inactivity exerts an economic impact on the SUS due to NCD hospitalization. Physical inactivity is a modifiable lifestyle and compelling evidence, including that of this article, supports the promotion of a more active community as one of the major targets of public health care policies.

https://doi.org/10.11606/s1518-8787.2023057004589

The burden of physical inactivity for the public health care system in Brazil
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Prodel, Eliza

; Mrejen, Matías

; Mira, Pedro Augusto de Carvalho

; Britto, Jorge

; Vargas, Marco Antonio

; Nobrega, Antonio Claudio Lucas

Revista de Saúde Pública

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2023, Volume 57 elocation 37

Abstract: En | Text: En | PDF: En

https://doi.org/10.11606/s1518-8787.2023057004589

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

LAPAROSCOPIC VERSUS OPEN SURGERY IN GASTRIC GASTROINTESTINAL STROMAL TUMORS LARGER THAN 5 CM: A SYSTEMATIC REVIEW AND META-ANALYSIS
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PITA ARAUJO, Francisco Antonio

; LOPES, Vítor Nuno Neves

; BARBOSA, Jose Pedro Coimbra de Vargas Lobarinhas

; MARTINS, Mariana Rafaela da Fonte

; BARBOSA, José

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2022, Volume 35 elocation e1711

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND: Surgical resection represents the main treatment for resectable nonmetastatic gastric gastrointestinal stromal tumors. Despite the feasibility and safety of laparoscopic resection, its standard use in gastric tumors larger than 5 cm is yet to be established. AIMS: This study aimed to compare the current evidence on laparoscopic resection with the classical open surgical approach in terms of perioperative, postoperative, and oncological outcomes. METHODS: The PubMed, Scopus, and Web of Science databases were consulted. Articles comparing the approach to gastric gastric gastrointestinal stromal tumors larger than 5 cm by open and laparoscopic surgery were eligible. A post hoc subgroup analysis based on the extent of the surgery was performed to evaluate the operative time, blood loss, and length of hospital stay. RESULTS: A total of nine studies met the eligibility criteria. In the study, 246 patients undergoing laparoscopic surgery and 301 patients undergoing open surgery were included. The laparoscopic approach had statistically significant lower intraoperative blood loss (p=0.01) and time to oral intake (p<0.01), time to first flatus (p<0.01), and length of hospital stay (0.01), compared to the open surgery approach. No significant differences were found when operative time (0.25), postoperative complications (0.08), R0 resection (0.76), and recurrence rate (0.09) were evaluated. The comparative subgroup analysis between studies could not explain the substantial heterogeneity obtained in the respective outcomes. CONCLUSION: The laparoscopic approach in gastric gastrointestinal stromal tumors larger than 5 cm compared to the open surgical approach is a technically safe and feasible surgical method with similar oncological results.

RESUMO RACIONAL: A resseção cirúrgica representa a principal forma de tratamento de tumores estromais gástricos não metastáticos ressecáveis. Apesar da viabilidade e segurança da ressecção laparoscópica, a sua utilização generalizada em tumores gástricos com mais de 5 centímetros ainda não foi estabelecida. OBJETIVOS: Comparar as evidências atuais sobre a resseção por via laparoscópica com a cirurgia aberta, em termos de resultados peri-, pós-operatórios e oncológicos. MÉTODOS: Foram consultadas as bases de dados PubMed, Scopus e Web of Science. Artigos que comparassem a abordagem de tumores estromais gástricos gástricos com tamanho superior a 5 centímetros por cirurgia aberta e por via laparoscópica foram incluídos. Uma análise de subgrupos post-hoc, com base na extensão da cirurgia, foi realizada para os outcomes tempo intra-operatório, perdas de sangue e tempo de hospitalização. RESULTADOS: Nove estudos cumpriram os critérios de elegibilidade, tendo sido incluídos 246 pacientes submetidos a cirurgia por via laparoscópica e 301 pacientes submetidos a cirurgia aberta. A abordagem laparoscópica apresentou perdas de sangue intra-operatórias (p=0,01) e tempos até alimentação oral (p<0,01), para primeiro flato (p<0,01) e de hospitalização (0,01) estatisticamente inferiores relativamente à abordagem por cirurgia aberta. Não foram encontradas diferenças significativas quando avaliados o tempo operatório (0,25), complicações pós-operatórias (0,08), resseção R0 (0,76) e taxa de recorrência (0,09). A análise de subgrupos comparativa não permitiu explicar a heterogeneidade substancial obtida nos respetivos outcomes. CONCLUSÕES: A via laparoscópica em tumores estromais gástricos superiores a 5 centímetros comparativamente com a abordagem por cirurgia aberta, constitui um método cirúrgico tecnicamente seguro e viável, com resultados oncológicos semelhantes.

https://doi.org/10.1590/0102-672020220002e1711

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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dec 2021, Volume 36 N. 6 Pages 725 - 735

Abstract: En | Text: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

Avaliação do Seguimento de um Ano dos Pacientes Incluídos no Registro Brasileiro de Síndromes Coronárias Agudas (ACCEPT)
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Silva, Pedro Gabriel Melo de Barros e

; Berwanger, Otavio

; Santos, Elizabete Silva dos

; Sousa, Antônio Carlos Sobral

; Cavalcante, Margaret Assad

; Andrade, Pedro Beraldo de

; Neuenschwander, Fernando Carvalho

; Vargas Filho, Hugo

; Guimarães, Jorge Ilha

; Andrade, Jadelson

; Paola, Angelo Amato Vincenzo de

; Malachias, Marcus Vinicius Bolivar

; Mattos, Luiz Alberto Piva e

; Precoma, Dalton Bertolim

; Bacal, Fernando

; Dutra, Oscar Pereira

Arquivos Brasileiros de Cardiologia

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jun 2020, Volume 114 N. 6 Pages 995 - 1003

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Existe carência de informações prospectivas sobre a evolução em um ano após uma síndrome coronária aguda (SCA) em uma grande amostra de pacientes brasileiros. Objetivos Avaliar a prescrição de terapias baseadas em evidência, a ocorrência de desfechos graves e os preditores para estes desfechos em um registro brasileiro multicêntrico de pacientes com SCA. Métodos O ACCEPT é um estudo observacional prospectivo que incluiu pacientes internados com diagnóstico de SCA em 47 hospitais brasileiros. Os pacientes foram seguidos por 1 ano e coletou-se dados sobre prescrição médica e ocorrência de eventos cardiovasculares maiores (mortalidade cardiovascular, reinfarto e acidente vascular encefálico - AVE). Valores de p < 0,05 foram considerados estatisticamente significantes. Resultados Um total de 5.047 pacientes foram incluídos neste registro, de agosto de 2010 até abril de 2014. Foi confirmado o diagnóstico de SCA em 4.782 pacientes (94,7%) e, dentre os 3 diagnósticos possíveis, o mais comum foi SCA com elevação do segmento ST (35,8%). A taxa de eventos cardiovasculares maiores foi de 13,6 % em 1 ano. A prescrição completa de terapias baseadas em evidência na admissão hospitalar foi de 62,1%. Idade, atendimento público, infarto agudo do miocárdio, AVE, insuficiência renal, diabetes e qualidade da terapia estiveram associados de forma independente à ocorrência de eventos cardiovasculares maiores. Conclusões No seguimento de 1 ano do registro ACCEPT, mais de 10% dos pacientes apresentaram eventos cardiovasculares maiores e esta taxa variou de acordo com a qualidade da terapia. Há necessidade da elaboração de estratégias para melhorar o uso de terapias baseadas em evidência no sentido de minimizar os eventos cardiovasculares na população brasileira. (Arq Bras Cardiol. 2020; 114(6):995-1003)

Abstract Background There is lack of prospective data on evolution within one year of acute coronary syndromes (ACS) in a representative population of Brazilian patients. Objectives To assess the prescription of evidence-based therapies, the incidence of severe outcomes and the predictors for these outcomes in a multicenter Brazilian registry of ACS patients. Methods The ACCEPT is a prospective observational study, which included patients hospitalized with a diagnostic of ACS in 47 Brazilian hospitals. The patients were followed for a 1 year and data were collected on the medical prescription and the occurrence of major cardiovascular events (cardiovascular mortality, reinfarction and cerebrovascular accident - CVA). Values of p < 0.05 were considered statistically significant. Results A total of 5,047 patients were included in this registry from August 2010 to April 2014. The diagnosis of ACS was confirmed in 4,782 patients (94.7%) and, among those, the most frequent diagnosis was ACS with ST segment elevation (35.8%). The rate of major cardiovascular events was 13.6 % within 1 year. Adherence to prescription of evidence-based therapy at admission was of 62.1%. Age, public service, acute myocardial infarction, CVA, renal failure, diabetes and quality of therapy were associated independently with the occurrence of major cardiovascular events. Conclusions During the one-year follow-up of the ACCEPT registry, more than 10% of the patients had major cardiovascular events and this rate ranged according with the quality of therapy. Strategies must be elaborated to improve the use of evidence-based therapies to minimize the cardiovascular events among the Brazilian population. (Arq Bras Cardiol. 2020; 114(6):995-1003)

https://doi.org/10.36660/abc.20190879 1002 downloads

Diversidad genética en dos huertos semilleros de Pinus patula Schiede ex SchltdL. et Cham.
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Méndez-Neri, Mónica

; Ramírez-Herrera, Carlos

; Vargas-Hernández, J. Jesús

; Martínez-Trinidad, Tomás

; López-Upton, Javier

; López, Pedro Antonio

Revista fitotecnia mexicana

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mar 2020, Volume 43 N. 1 Pages 113 - 119

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Summary Genetic diversity is important in seed orchards to produce plants with high capability of adaptation to environmental changes; thus, the objective of this study was to evaluate the genetic diversity and structure of two asexual seed orchards of Pinus patula and to determine the degree of differentiation of each orchard. The first orchard is located at common land La Selva, municipality of Huayacocotla, Veracruz, Mexico and the second one at common land Villa Cuauhtémoc, municipality of Chignahuapan, Puebla. Mexico. Each orchard was established with phenotypically superior cloned trees selected in their own area. Foliage samples were collected from one ramet from each clone in both orchards. Microsatellite molecular markers NZPR114, NZPR5, PtTX2123, PtTX2146, PtTX3107 and PtTX3127 were used to perform the genetic diversity analysis. The average number of alleles per locus was 9.9 for both seed orchards. The observed and expected heterozygosities were 0.602 and 0.693, respectively. The fixation index was 0.125. A deficit of heterozygotes was found when both seed orchards were analyzed jointly (FIT = 0.125) and within each of the orchards (FIS = 0.105). The differentiation index was low (FST = 0.023). Most of the genetic diversity was found within the orchards with only 4.5 % between them. The genetic diversity was high in the asexual orchards of P. patula with moderate deficiency of heterozygotes and low level of differentiation between both seed orchards.

Resumen La diversidad genética es importante en los huertos semilleros para producir plantas con alta capacidad de adaptación a cambios ambientales; por lo tanto, el objetivo del presente estudio fue evaluar la diversidad y estructura genética de dos huertos semilleros asexuales de Pinus patula y determinar el grado de diferenciación de cada huerto. El primer huerto se localiza en el ejido La Selva, municipio de Huayacocotla, Veracruz, México y el segundo en el ejido Villa Cuauhtémoc, municipio de Chignahuapan, Puebla, México. Cada huerto se estableció con árboles clonados fenotípicamente superiores seleccionados en su propia área. Muestras de follaje se recolectaron de un rameto de cada clon en ambos huertos semilleros. Los marcadores moleculares de microsatélite NZPR1078, NZPR114, NZPR5, PtTX2123, PtTX2146, PtTX3107 y PtTX3127 se usaron para realizar el análisis de diversidad genética. El número promedio de alelos por locus fue 9.9 para ambos huertos semilleros. La heterocigosidad observada y la esperada fueron 0.602 y 0.693, respectivamente. El índice de fijación fue 0.125. Un déficit de heterocigotos se encontró cuando los dos huertos semilleros se analizaron en conjunto (FIT = 0.125) y dentro de cada uno de estos (FIS = 0.105). El índice de diferenciación fue bajo (FST = 0.023). La mayor parte de la diversidad genética se encontró dentro de los huertos con sólo 4.5 % entre éstos. La diversidad genética fue alta en los huertos asexuales de P. patula con deficiencias moderadas de heterocigotos y un nivel bajo de diferenciación entre ambos huertos semilleros.

https://doi.org/10.35196/rfm.2020.1.113 647 downloads

Nuevos causantes de la pudrición en panel de pica en hule: caso Fusarium spp.
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López-Moreno, Bernardo

; Gutiérrez Contreras, Maribel

; Aguirre Paleo, Salvador

; Vargas-Sandoval, Margarita

; Guzmán de Casa, Atahualpa

; García-Saucedo, Pedro Antonio

; Ávila-Val, Teresita del Carmen

Revista mexicana de ciencias agrícolas

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nov 2019, Volume 10 N. spe23 Pages 277 - 289

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Moldy rot on the rubber sting panel decreases the yield and regeneration of its bark. The objective was to identify the causative agent of the disease in San Juan Bautista Tuxtepec, Oaxaca and evaluate its in vitro sensitivity to fungicides. To this end, tissue from the diseased sting panel was collected and made insulations. The isolates were characterized in the nutritive media PDA (papa-dextrose-agar), CLA (carnation leaves-agar), FLA (liquid fermentation-agar), CDA (coffee-dextrose-agar) and ZA (carrot-agar). Growth rates were evaluated and pathogenicity tests were carried out in the laboratory and in the field, as well as in vitro sensitivity to Mancozeb 70%, Benomilo, Carbendazin, Propiconazole, Chlorothalonil, and Carboxamide, in 10 treatments and eight repetitions. The results showed four isolates of the genus Fusarium, which showed polymorphism according to the culture medium, with radial growth and marked rings. Microconidia and macroconidia dispersed in the mycelium and white, orange and blue sporodochs were observed at 36 days. The growth rate varied with the nutrient medium and the inoculated strain. F. circinatum, F. lateririum, F. decemcellulare and F. mangiferae were identified. In the laboratory pathogenicity tests all inoculated strains were positive and in the field only F. circinatum and F. mangiferae. The sensitivity bioassay showed fungicide-dependent response and isolation. These results allow us to conclude that the species F. circinatum, F. mangiferae, F. lateririum and F. decemcellulare can cause moldy rot in the sting panel of clone IAN 710. This is a first report that involves these species. Its control depends on the species of Fusarium and the fungicide used.

Resumen La pudrición mohosa en el panel de pica de hule disminuye el rendimiento y la regeneración de su corteza. El objetivo fue identificar el agente causal de la enfermedad en San Juan Bautista Tuxtepec, Oaxaca y evaluar su sensibilidad in vitro a fungicidas. Para ello se colectó tejido del panel de pica enfermo y realizaron aislamientos. Se caracterizaron los aislados en los medios nutritivos PDA (papa-dextrosa-agar), CLA (hojas de clavel-agar), FLA (fermentación líquida-agar), CDA (café-dextrosa-agar) y ZA (zanahoria-agar). Se evaluaron tasas de crecimiento y realizaron pruebas de patogenicidad en laboratorio y campo, así como de sensibilidad in vitro a Mancozeb 70%, Benomilo, Carbendazin, Propiconazol, Clorotalonil, y Carboxamida, en 10 tratamientos y ocho repeticiones. Los resultados evidenciaron cuatro aislados del género Fusarium, que mostraron polimorfismo de acuerdo con el medio de cultivo, con crecimiento radial y anillos marcados. Se observaron microconidios y macroconidios dispersos en el micelio y en esporodoquios de color blanco, naranja y azul a 36 días. La tasa de crecimiento varió con el medio nutritivo y la cepa inoculada. Se identificaron a F. circinatum, F. lateririum, F. decemcellulare y F. mangiferae. En las pruebas de patogenicidad en laboratorio todas las cepas inoculadas fueron positivas y en campo solo F. circinatum y F. mangiferae. El bioensayo de sensibilidad mostró respuesta dependiente de fungicida y aislamiento. Con estos se concluye que las especies F. circinatum, F. mangiferae, F. lateririum y F. decemcellulare pueden causar pudrición mohosa en el panel de pica del clon IAN 710. Este es un primer reporte que involucra estas especies. Su control depende de la especie de Fusarium y el fungicida utilizado.

https://doi.org/10.29312/remexca.v0i23.2027 314 downloads

II Consenso Colombiano para el Manejo de la Osteoporosis Posmenopáusica
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Medina-Orjuela, Adriana

; Rosero-Olarte, Óscar

; Rueda-Plata, Pedro Nel

; Sánchez-Escobar, Fabio

; Chalem-Choueka, Monique

; González-Reyes, Miguel Ángel

; Román-González, Alejandro

; Terront-Lozano, Alexandra

; Páez-Talero, Amanda

; Rueda-Beltz, Camilo

; Builes-Barrera, Carlos Alfonso

; Pérez-Niño, Carlos Augusto

; Fernández-Ávila, Daniel G.

; Vásquez-Awad, David

; González-Devia, Deyanira

; Pinilla-Pabón, Edgar

; Reina-Valdivieso, Eduardo Antonio

; Vásquez-Mejía, Esdras Martín

; Vargas-Grajales, Francisco Iván

; Linares-Restrepo, Francisco

; Altamar-Canales, Geraldine

; Molina-Uribe, Gustavo Adolfo

; Pineda-Acero, Gustavo Adolfo

; Arenas-Quintero, Henry Mauricio

; Vélez-Patino, Jorge Augusto

; Molina-Restrepo, José Fernando

; Jaller-Raad, Juan José

; Londoño-Gutiérrez, Ricardo

Revista Colombiana de Reumatología

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sep 2018, Volume 25 N. 3 Pages 184 - 210

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La Asociación Colombiana de Osteoporosis y Metabolismo Mineral se reunió a principios de 2017 para actualizar el Consenso Colombiano de Osteoporosis, elaborado por primera vez en 2005, un paso que se consideró necesario en vista del subdiagnóstico de esta enfermedad, el impacto esperado del envejecimiento poblacional y los cambios en el tratamiento farmacológico que ha habido desde entonces. Se seleccionó un equipo técnico con especialistas de múltiples áreas y amplia trayectoria, repartidos en 4 grupos de trabajo: definición y epidemiología, diagnóstico, tratamiento farmacológico y medidas no farmacológicas. Luego de una revisión de la literatura científica, en reuniones de trabajo se generaron las definiciones y recomendaciones que se resumen en este documento.

Abstract The Colombian Osteoporosis and Mineral Metabolism Association met in early 2017 to update the Colombian Consensus on Osteoporosis. This was first issued in 2005, and is seen as a necessary step in view of the underdiagnosed status of this disease, and the expected impact of population ageing. A technical team was formed with specialists with long experience across multiple disciplines, who were assigned to four working groups: definitions and epidemiology, diagnosis, pharmacological treatment, and non-pharmacological treatment. After a scientific literature review and a series of meetings, the definitions and recommendations are summarised in this article.

https://doi.org/10.1016/j.rcreu.2018.02.006 11107 downloads

10.

Impulse control and related disorders in Parkinson’s disease
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Vargas, Antonio Pedro

; Cardoso, Francisco Eduardo Costa

Arquivos de Neuro-Psiquiatria

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jun 2018, Volume 76 N. 6 Pages 399 - 410

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Alterações neuropsiquiátricas são comuns na doença de Parkinson e estão presentes em todas as fases da enfermidade. No entanto, frequentemente não são reconhecidas e recebem tratamento insuficiente. Ao longo dos últimos anos, observou-se que a terapia de reposição dopaminérgica pode levar ao desenvolvimento ou piora de condições como transtorno do jogo, compulsão por sexo, compras, e comida, além da síndrome de desregulação dopaminérgica e punding. Sua fisiopatologia parece estar relacionada à estimulação dopaminérgica anormal das regiões basais dos núcleos da base, sobretudo pelas vias nigro-mesolímbicas. O presente artigo tem como objetivo fazer uma revisão da literatura a respeito de impulsividade, transtornos do controle de impulso e condições relacionadas na doença de Parkinson, com foco na epidemiologia, características clínicas e tratamento.

ABSTRACT Neuropsychiatric disorders are common among patients with Parkinson’s disease and may appear in any stage of the disease. However, these disorders often go undiagnosed and receive insufficient treatment. Observations in recent years have revealed that dopamine replacement therapy may lead to the development or worsening of conditions, such as gambling disorder, compulsive sexual behavior, compulsive buying and binge eating, in addition to punding and dopamine dysregulation syndrome. The pathophysiology of these disorders seems to be related to abnormal dopaminergic stimulation of the basal regions of the basal ganglia, especially via nigro-mesolimbic pathways. The aim of the present study was to perform a literature review on impulsivity, impulse control disorders and related conditions among patients with Parkinson’s disease, with emphasis on their epidemiology, clinical characteristics and treatment.

https://doi.org/10.1590/0004-282x20180052 4339 downloads

11.

The relative frequency of common neuromuscular diagnoses in a reference center
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Cotta, Ana

; Paim, Júlia Filardi

; Carvalho, Elmano

; da-Cunha-Júnior, Antonio Lopes

; Navarro, Monica M.

; Valicek, Jaquelin

; Menezes, Miriam Melo

; Nunes, Simone Vilela

; Xavier-Neto, Rafael

; Baptista Junior, Sidney

; Lima, Luciano Romero

; Takata, Reinaldo Issao

; Vargas, Antonio Pedro

Arquivos de Neuro-Psiquiatria

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nov 2017, Volume 75 N. 11 Pages 789 - 795

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O procedimento diagnóstico neuromuscular é complexo. O conhecimento da frequência relativa das doenças neuromusculares em uma população é importante para utilização dos testes diagnósticos mais apropriados. Objetivo: Relatar a frequência relativa de doenças neuromusculares em um centro de referência. Métodos: Revisão de prontuários de pacientes com suspeita de miopatia em 17 anos. Resultados: Dentre 3412 exames, 1603 (46,98%) foram confirmatórios: 782 (48,78%) estudos moleculares e 821 (51,21%) biópsias musculares. Os diagnósticos mais frequentes foram: distrofinopatia 460 (28,70%), mitocondriopatia 330 (20.59%), atrofia muscular espinhal 158 (9,86%), distrofia muscular cintura-membros 157 (9,79%), distrofia miotônica de Steinert 138 (8,61%), distrofia muscular face-escápulo-umeral 99 (6,17%) e outros diagnósticos 261 (16,28%). Conclusão: Utilizando as técnicas diagnósticas atualmente disponíveis em nosso serviço, o diagnóstico específico do subtipo de distrofia muscular cintura-membros foi obtido em 61% dos pacientes. O diagnóstico neuromuscular apropriado é importante para o aconselhamento genético, orientações de reabilitação e tratamento precoce de complicações respiratórias e cardíacas.

ABSTRACT The diagnostic procedure in neuromuscular patients is complex. Knowledge of the relative frequency of neuromuscular diseases within the investigated population is important to allow the neurologist to perform the most appropriate diagnostic tests. Objective: To report the relative frequency of common neuromuscular diagnoses in a reference center. Methods: A 17-year chart review of patients with suspicion of myopathy. Results: Among 3,412 examinations, 1,603 (46.98%) yielded confirmatory results: 782 (48.78%) underwent molecular studies, and 821 (51.21%) had muscle biopsies. The most frequent diagnoses were: dystrophinopathy 460 (28.70%), mitochondriopathy 330 (20.59%), spinal muscular atrophy 158 (9.86%), limb girdle muscular dystrophy 157 (9.79%), Steinert myotonic dystrophy 138 (8.61%), facioscapulohumeral muscular dystrophy 99 (6.17%), and other diagnoses 261 (16.28%). Conclusion: Using the presently-available diagnostic techniques in this service, a specific limb girdle muscular dystrophy subtype diagnosis was reached in 61% of the patients. A neuromuscular-appropriate diagnosis is important for genetic counseling, rehabilitation orientation, and early treatment of respiratory and cardiac complications.

https://doi.org/10.1590/0004-282x20170151 2305 downloads

12.

Prevalence of hypothyroidism in major psychiatric disorders in hospitalised patients in Montserrat Hospital during the period March to October 2010
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Vargas Navarro, Pedro

; Ibañez Pinilla, Edgar Antonio

; Galeano Espana, Alejandra

; Noguera Bravo, Ana María

; Pantoja, Sandra Milena

; Suárez Acosta, Ana María

Revista Colombiana de Psiquiatría

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sep 2017, Volume 46 N. 3 Pages 140 - 146

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: El hipotiroidismo resulta de una inadecuada producción de hormonas tiroideas. Es conocido que existe una relación entre los trastornos psiquiátricos mayores y el hipotiroidismo. Objetivo: Determinar la prevalencia de hipotiroidismo en los pacientes hospitalizados por trastorno psiquiátrico mayor en la Clínica Montserrat en el periodo de marzo a octubre de 2010. Material y métodos: Se realizó un estudio descriptivo transversal, para el que se seleccionó una muestra de 105 pacientes que ingresaron a la Clínica Montserrat con diagnóstico de trastorno psiquiátrico mayor (depresión mayor, trastorno afectivo bipolar, trastorno de ansiedad generalizada, trastornos de ansiedad, trastorno mixto ansioso-depresivo y esquizofrenia) en el periodo mencionado. Para evaluar el hipotiroidismo se realizó una prueba de Hormona Estimulante del Tiroides (TSH). Resultados: La prevalencia general del hipotiroidismo fue del 10,5% (intervalo de confianza del 95%, 5%-16%). Al determinar el hipotiroidismo por diagnóstico, se encontró que había mayor prevalencia en los trastorno de pánico (12,5%) y depresivo (11,1%) y menor en el trastorno bipolar (10,3%) y la esquizofrenia (9,9%). Conclusiones: La prevalencia general del hipotiroidismo fue menor que en la población general (18,5-4,6%) y se encontró hipotiroidismo en otros trastornos diferentes de la depresión.

Abstract Introduction: Hypothyroidism results from inadequate production of thyroid hormone. It is known that there is a relationship between the major psychiatric disorders and hypothyroidism. Objective: To determine the prevalence of hypothyroidism in patients admitted due to major psychiatric disorders in Montserrat Hospital during the period from March to October 2010. Material and methods: A descriptive cross-sectional study was conducted on 105 patients admitted to Montserrat Hospital with a primary diagnosis of major psychiatric disorder (major depression, bipolar affective disorder, generalised panic disorder, panic disorder, mixed anxiety-depressive disorder, and schizophrenia) in the aforementioned period. Thyroid stimulating hormone (TSH) was performed to assess the evidence of hypothyroidism. Results: The overall prevalence of hypothyroidism was found to be 10.5% (95%CI, 5-16%). It was 12.5% in anxiety disorder, 11.1% in depressive disorder, with a lower prevalence of 10.3% for bipolar disorder, and 9.9% for schizophrenia. Conclusions: The overall prevalence of hypothyroidism was found to be less than in the general population, which is between 4.64% and 18.5%, and hypothyroidism was found in disorders other than depression.

https://doi.org/10.1016/j.rcpeng.2017.06.001 489 downloads

13.

Documento del grupo de trabajo SESPAS-OMC sobre iatrogenia
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Abraira, Víctor

; Conde Olasagasti, Pepe

; Font, Javier

; Garrote, Juan Manuel

; Jiménez, José Luis

; Kovacs, Santiago

; Laborda, Eugenio

; Larios, David

; Perea, Bernardo

; Rodríguez Sendín, Juan José

; Romero, Serafín

; Sánchez, Galo

; Aibar Remón, Carlos

; Astray, Jenaro

; Barbero, Antonio

; Busquets Font, Josep M

; Campillo Artero, Carlos

; Carrasco, Miguel

; María, Francesc J

; López-Valcárcel, Beatriz G

; Larisgoitia, Itziar

; Meneu, Ricard

; Plans Rubió, Pedro

; Segura Benedicto, Andreu

; Vargas Marcos, Francisco

FEM: Revista de la Fundación Educación Médica

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2017, Volume 20 N. 6 Pages 255 - 264

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.33588/fem.206.925 724 downloads

14.

"Consideraciones sobre la determinación del tiempo de residencia de la prueba en la lixiviación industrial del proceso "Caron" en la planta de Punta Gorda Moa, Cuba"
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Chang-Cardona, Antonio R.

; Terencio-Guevara, Pedro L.

; Guerra-González, Yosbel

; Rojas-Vargas, Armando

Tecnología Química

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apr 2015, Volume 35 N. 1 Pages 18 - 31

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

In the present experimental work it was obtained, on a Production Demonstration Unit (UDP) of leaching commercial plant, an exponential statistical mathematical model with a distribution coefficient (R² = 0,9998), characterized by the equation TR = 13297*(Qpulpa)-0.999;min, to determine the real residence time (TR) of the pulp in the miniseries of first stage of the leaching plant (IraEL) in "Punta Gorda", as a function of the pulp flow (Qpulpa) that is feeded to each miniserie of turbo-aereator (TA) inside the range of values of (105 at 282) m³/h, that makes valid, also, the effectiveness of the modification to the methodology of processing of the experimental results, obtained when using the Na2CO3 like tracer, based on the method of successive approaches that facilitates to determine the TR under the peculiar industrial conditions of the ammonia - carbonate leaching of lateritic reduced ores, in whose process, the useful volume of the miniseries diminishes with the operation time. This premise will allow to optimize in future works at commercial scale, the specific velocity of the air [Qa, m³/(t·min)] and its corresponding: specific volumes of air (Va, m³/t) and volumetric air flows (Ga, m³/h) in each TA with the economic purpose of increasing those leached of Ni and Co in the IraEL.

En el presente trabajo experimental se obtuvo a escala de Unidad Demostrativa de Producción (UDP) un modelo matemático estadístico exponencial con un coeficiente de distribución (R²= 0,9998) para determinar el tiempo de residencia real (TR) de la pulpa en las miniseries de Ira Etapa de la Planta de Lixiviación (IraEL) de la Empresa de Punta Gorda, en función del flujo de pulpa (Qpulpa) que se alimenta a cada miniserie de turbo-aireadores (TA) dentro del rango de valores de (105 a 282) m³/h, caracterizado por la ecuación TR = 13297*(Qpulpa)-0.999;min, la cual, también valida, la efectividad de la modificación a la metodología de procesamiento de los resultados experimentales, obtenidos al emplear el carbonato de sodio como trazador, basada en el método de aproximaciones sucesivas que posibilita determinar el TR en las condiciones industriales particulares de la lixiviación carbonato-amoniacal de minerales lateríticos reducidos, en cuyo proceso, el volumen útil de las miniseries disminuye con el tiempo de operación. Esta premisa permitirá optimizar, en futuros trabajos a escala comercial, la velocidad específica del aire [Qa, m³/(t·min)] y sus correspondientes: volúmenes de aire específicos (Va, m³/t) y flujos volumétricos (Ga, m³/h) en cada TA con la finalidad económica de incrementar los lixiviados de Ni y Co en la IraEL.

54 downloads

15.

Common recessive limb girdle muscular dystrophies differential diagnosis: why and how?
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Cotta, Ana

; Carvalho, Elmano

; da-Cunha-Júnior, Antonio Lopes

; Paim, Júlia Filardi

; Navarro, Monica M.

; Valicek, Jaquelin

; Menezes, Miriam Melo

; Nunes, Simone Vilela

; Xavier Neto, Rafael

; Takata, Reinaldo Issao

; Vargas, Antonio Pedro

Arquivos de Neuro-Psiquiatria

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sep 2014, Volume 72 N. 9 Pages 721 - 734

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As distrofias musculares progressivas cintura-membros são desordens neuromusculares hereditárias autossômicas heterogêneas. Elas produzem alterações distróficas à biópsia muscular e estão associadas a mutações em diversos genes envolvidos na estrutura e função muscular. Fluxograma diagnóstico, fotos, tabelas e diagramas ilustrados dos aspectos clínicos, laboratoriais e de imagem são apresentados para o diagnóstico diferencial de distrofias musculares cintura-membros autossômicas recessivas comuns, diagnosticadas atualmente em um centro de referência no Brasil. Exames de imagem pré-operatórios direcionam o local da biópsia muscular. O padrão de envolvimento muscular difere de acordo com o subtipo de distrofia muscular cintura-membros. A substituição fibroadiposa do tecido muscular é mais acentuada no compartimento posterior da coxa na calpainopatia e proteinopatia relacionada à fukutina; anterior da coxa na sarcoglicanopatia; difusa na coxa na disferlinopatia e teletoninopatia. O diagnóstico diferencial preciso das distrofias musculares cintura-membros é importante para o aconselhamento genético, orientação prognóstica, tratamento cardíaco e respiratório. Além disso poderá, no futuro, provavelmente, propiciar terapias gênicas específicas para cada subtipo.

Limb girdle muscular dystrophies are heterogeneous autosomal hereditary neuromuscular disorders. They produce dystrophic changes on muscle biopsy and they are associated with mutations in several genes involved in muscular structure and function. Detailed clinical, laboratorial, imaging, diagnostic flowchart, photographs, tables, and illustrated diagrams are presented for the differential diagnosis of common autosomal recessive limb girdle muscular dystrophy subtypes diagnosed nowadays at one reference center in Brazil. Preoperative image studies guide muscle biopsy site selection. Muscle involvement image pattern differs depending on the limb girdle muscular dystrophy subtype. Muscle involvement is conspicuous at the posterior thigh in calpainopathy and fukutin-related proteinopathy; anterior thigh in sarcoglycanopathy; whole thigh in dysferlinopathy, and telethoninopathy. The precise differential diagnosis of limb girdle muscular dystrophies is important for genetic counseling, prognostic orientation, cardiac and respiratory management. Besides that, it may probably, in the future, provide specific genetic therapies for each subtype.

https://doi.org/10.1590/0004-282X20140110 11956 downloads Cited 2 times in SciELO

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