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BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought to identify the viral etiology of equine encephalitis in Espírito Santo state. METHODS We performed viral culture in C6/36 cells, molecular detection of WNV genome, histopathology and immunohistochemistry from horse cerebral tissue. We also carried out sequencing, phylogenetic analysis and molecular clock. FINDINGS Histopathologic analysis from horse cerebral tissue showed injury related to encephalitis and WNV infection was confirmed by immunohistochemistry. The virus was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) from brain tissue and subsequently isolated in C6/36 cells. WNV full-length genome was sequenced showing the isolated strain belongs to lineage 1a. The molecular clock indicated that Brazilian WNV strain share the same common ancestor that were circulating in US during 2002-2005. MAIN CONCLUSIONS Here we report the first isolation of WNV in Brazil from a horse with neurologic disease, which was clustered into lineage 1a with others US WNV strains isolated in beginning of 2000’s decade.

https://doi.org/10.1590/0074-02760180332 3810 downloads

Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child
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Vieira, Marcelo Adriano da Cunha e Silva

; Castro, Alzira Almeida de Sousa

; Henriques, Daniele Freitas

; Silva, Eliana Vieira Pinto da

; Tavares, Fernando Neto

; Martins, Lívia Carício

; Guimarães, Lucas Melo

; Monteiro, Talita Antonia Furtado

; Azevedo, Raimunda do Socorro da Silva

; Cruz, Ana Cecíclia Ribeiro

; Vasconcelos, Pedro Fernando da Costa

Revista da Sociedade Brasileira de Medicina Tropical

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jun 2018, Volume 51 N. 3 Pages 390 - 392

Abstract: En | Text: En | PDF: En

Abstract We report a case of encephalitis associated with Zika virus infection and reactivation of varicella-zoster virus in the central nervous system of a Brazilian child. This case raises the possibility that reactivation of the latent varicella-zoster virus may be a mechanism of neurological impairment induced by acquired Zika virus infection.

https://doi.org/10.1590/0037-8682-0447-2017 1559 downloads

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases
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Vieira, Marcelo Adriano da Cunha e Silva

; Costa, Carlos Henrique Nery

; Linhares, Alexandre da Costa

; Borba, Amariles de Sousa

; Henriques, Daniele Freitas

; Silva, Eliana Vieira Pinto da

; Tavares, Fernando Neto

; Batista, Francisca Miriane de Araújo

; Guimarães, Herlon Clístenes Lima

; Martins, Lívia Carício

; Monteiro, Talita Antônia Furtado

; Cruz, Ana Cecília Ribeiro

; Azevedo, Raimunda do Socorro da Silva

; Vasconcelos, Pedro Fernando da Costa

Memórias do Instituto Oswaldo Cruz

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2018, Volume 113 N. 11 elocation e170538

Abstract: En | Text: En | PDF: En

This study showed that laboratory markers of recent infection by dengue, Zika or chikungunya arboviruses were detected in the biological samples of approximately one-third of patients with encephalitis, myelitis, encephalomyelitis or Guillain-Barré syndrome, in a surveillance programme in Piauí state, Brazil, between 2015-2016. Fever and myalgia had been associated with these cases. Since in non-tropical countries most infections or parainfectious diseases associated with the nervous system are attributed to herpesviruses, enteroviruses, and Campylobacter jejuni, the present findings indicate that in tropical countries, arboviruses may now play a more important role and reinforce the need for their surveillance and systematic investigation in the tropics.

https://doi.org/10.1590/0074-02760170538 2004 downloads

Características dos primeiros casos de microcefalia possivelmente relacionados ao vírus Zika notificados na Região Metropolitana de Recife, Pernambuco
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Vargas, Alexander

; Saad, Eduardo

; Dimech, George Santiago

; Santos, Roselene Hans

; Sivini, Maria Auxiliadora Vieira Caldas

; Albuquerque, Luciana Carolina

; Lima, Patricia Michelly Santos

; Barreto, Idalacy de Carvalho

; Andrade, Michelly Evangelista de

; Estima, Nathalie Mendes

; Carvalho, Patrícia Ismael de

; Azevedo, Rayane Souza de Andrade

; Vasconcelos, Rita de Cássia de Oliveira

; Assunção, Romildo Siqueira

; Frutuoso, Lívia Carla Vinhal

; Carmo, Greice Madeleine Ikeda do

; Souza, Priscila Bochi de

; Wada, Marcelo Yoshito

; Oliveira, Wanderson Kleber de

; Henriques, Cláudio Maierovitch Pessanha

; Percio, Jadher

Epidemiologia e Serviços de Saúde

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dec 2016, Volume 25 N. 4 Pages 691 - 700

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo OBJETIVO: descrever os primeiros casos de microcefalia possivelmente relacionados ao vírus Zika em nascidos vivos notificados na Região Metropolitana do Recife, Pernambuco, Brasil. MÉTODOS: estudo descritivo de tipo série de casos (notificados de 1º de agosto a 31 de outubro de 2015), com dados obtidos dos registros médicos e de questionário aplicado às mães. RESULTADOS: foram confirmados 40 casos com microcefalia, distribuídos em oito municípios da Região Metropolitana do Recife, com maior concentração no Recife (n=12); a mediana do perímetro cefálico foi de 29 cm, do perímetro torácico, 31 cm, e do peso, 2.628 gramas; 21/25 casos apresentaram calcificação cerebral, ventriculomegalia ou lisencefalia; entre as 40 mães, 27 referiram exantema na gestação, 20 no primeiro trimestre e sete no segundo, além de prurido, cefaleia, mialgia e ausência de febre. CONCLUSÃO: a maioria dos casos apresentou características de infecção congênita; a maioria das mães apresentou quadro sugestivo de infecção pelo vírus Zika na gestação.

Abstract OBJECTIVE: to describe the first cases of microcephaly possibly related to Zika virus in live born babies reported in the Metropolitan Region of Recife, Pernambuco State, Brazil. METHODS: this was a descriptive case series study (cases reported between August 1st and October 31st 2015), using medical record data and data from a questionnaire answered by the mothers of the babies. RESULTS: 40 microcephaly cases were confirmed, distributed in eight municipalities within the Metropolitan Region, with Recife itself having the highest concentration of cases (n=12); median head circumference was 29 cm, median chest girth was 31 cm and median weight was 2,628 grams; 21/25 cases had brain calcification, ventriculomegaly or lissencephaly; 27 of the 40 mothers reported rash during pregnancy, 20 in the first trimester and 7 in the second trimester, as well as itching, headache, myalgia and absence of fever. CONCLUSION: the majority of the cases bore the characteristics of congenital infection; the clinical condition of the majority of mothers suggested Zika virus infection during pregnancy.

Resumen OBJETIVO: describir los primeros casos de microcefalia en nacidos vivos reportados al Departamento de Salud del Estado de Pernambuco, en la región metropolitana de Recife, Pernambuco, 2015. MÉTODOS: estudio epidemiológico descriptivo de serie de casos (reportados de 1 de agosto a 31 de octubre de 2015), con datos obtenidos de registros médicos y cuestionarios aplicados a las madres. RESULTADOS: 40 casos fueron confirmados con microcefalia, en ocho municipios de la región metropolitana de Recife, con mayor concentración de casos en Recife (n=12); la circunferencia media de la cabeza fue 29 cm, perímetro torácico 31 cm y peso 2.628 gramos; exámenes revelaron que 21/25 casos mostraron calcificación, dilatación ventricular o lisencefalia; de las 40 madres, 27 (68%) informan exantema durante la gestación, 20 (74%) en el primer trimestre y siete (26%) en la segunda, además de prurito, dolor de cabeza, mialgia y ausencia de fiebre. CONCLUSIÓN: la mayoría de los casos presenta características de infección congénita; la mayoría de las madres mostró características que sugieren infección por el virus Zika en el embarazo.

https://doi.org/10.5123/s1679-49742016000400003 3740 downloads

Características dos primeiros casos de microcefalia possivelmente relacionados ao vírus Zika notificados na Região Metropolitana de Recife, Pernambuco
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Vargas, Alexander

; Saad, Eduardo

; Dimech, George Santiago

; Santos, Roselene Hans

; Sivini, Maria Auxiliadora Vieira Caldas

; Albuquerque, Luciana Carolina

; Lima, Patricia Michelly Santos

; Barreto, Idalacy de Carvalho

; Andrade, Michelly Evangelista de

; Estima, Nathalie Mendes

; Carvalho, Patrícia Ismael de

; Azevedo, Rayane Souza de Andrade

; Vasconcelos, Rita de Cássia de Oliveira

; Assunção, Romildo Siqueira

; Frutuoso, Lívia Carla Vinhal

; Carmo, Greice Madeleine Ikeda do

; Souza, Priscila Bochi de

; Wada, Marcelo Yoshito

; Oliveira, Wanderson Kleber de

; Henriques, Cláudio Maierovitch Pessanha

; Percio, Jadher

Epidemiologia e Serviços de Saúde

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dec 2016, Volume 25 N. 4 Pages 691 - 700

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5123/s1679-49742016000400003 22574 downloads

Taxa de gestação de receptoras de embriões bovinos tratadas com um análogo do GnRH no momento da inovulação
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Loiola, Marcus Vinícius Galvão

; Pereira, Danilo Francisco Campo

; Vasconcelos, Livia Vieira

; Lima, Marcos Chalhoub Coelho

; Ferraz, Priscila Assis

; Rodrigues, Alexandra Soares

; Bittencourt, Rodrigo Freitas

; Jesus, Edivânia Oliveira de

; Ribeiro Filho, Antonio de Lisboa

Revista Brasileira de Saúde e Produção Animal

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sep 2014, Volume 15 N. 3 Pages 782 - 789

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo com este estudo foi avaliar a taxa de gestação de receptoras de embriões bovinos categorizadas de acordo com a qualidade do corpo lúteo (CL) e tratadas ou não com um análogo de GnRH (Fertirelina) no momento da inovulação. Somente os embriões viáveis foram selecionados para inovulação (1- excelente, 2- bom e 3- regular) e transferidos. Para tanto, 272 novilhas foram distribuídas em seis grupos: CL1-S/GnRH (receptoras com área do CL < 1,5cm² e não tratadas com GnRH, n =26); CL1-C/GnRH (receptoras com área do CL < 1,5cm² e tratadas com GnRH, n=29); CL2-S/GnRH (receptoras com área do CL entre 1,5 e 2,0cm² e não tratadas com GnRH, n =46); CL2-C/GnRH (receptoras com área do CL entre 1,5 e 2,0cm² e tratadas com GnRH, n=45); CL3-S/GnRH (receptoras com área do CL > 2,0cm² e não tratadas com GnRH, n=63); e CL3-C/GnRH (receptoras com área do CL > 2cm² e tratadas com GnRH, n=63). As taxas de gestação das receptoras de embrião em relação à qualidade do CL e a aplicação ou não do GnRH foram respectivamente, 43,31 e 41,38%, 56,52 e 46,67%, e 46,03 e 42,86% para CL1-S/GnRH e CL1-C/GnRH, CL2-S/GnRH e CL2-C/GnRH, e CL3-S/GnRH e CL3-C/GnRH. Não houve diferença (P>0,05) entre as variáveis avaliadas. Portanto, a administração do análogo de GnRH (Fertirelina) não elevou a taxa de gestação em receptoras de embriões bovinos, independente da qualidade do CL, demonstrando que esta estratégia não foi eficaz em incrementar os índices de fertilidade.

The aim of the study was to evaluate the pregnancy rate of bovine embryo recipients categorized according to quality of the corpus luteum (CL), treated or not with a GnRH analogue (Fertirelina) at the time of embryo transfer. Only viable embryos were selected for embryo transfer (1 - excellent, 2 - good, 3 - fair) and transferred. Therefore, 272 heifers were divided into six groups: CL1-S/GnRH (recipients with CL area < 1,5cm² and not treated with GnRH, n = 26); CL1-C/GnRH (recipients with CL area < 1,5cm² and treated with GnRH, n = 29); CL2-S/GnRH (recipients with CL area between 1,5 and 2,0cm² and not treated with GnRH, n = 46); CL2-C/GnRH (recipients with CL area between 1,5 and 2,0cm² and treated with GnRH, n = 45); CL3-S/GnRH (recipients witch CL area > 2cm² and not treated with GnRH, n = 63); and CL3-C/GnRH (recipients witch CL area > 2cm² and treated with GnRH, n = 63). Pregnancy rates of embryo recipients in relation to CL quality and the application or otherwise of GnRH were 43.31% and 41.38, 56.52 and 46.67%, 46.03 and 42.86% for CL1-S/GnRH and CL1-C/GnRH, CL2-S/GnRH and CL2-C/GnRH and CL3-S/GnRH and CL3-C/GnRH, respectively. Therefore, administration of GnRH analogue (Fertirelina) did not increase the pregnancy rate in bovine embryo recipients, independent of the quality of CL, demonstrating that this strategy is not effective in increasing fertility rates.

1633 downloads

Persistence of experimental Rocio virus infection in the golden hamster (Mesocricetus auratus)
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Henriques, Daniele Freitas

; Quaresma, Juarez Antonio Simões

; Fuzii, Helen Thais

; Nunes, Márcio Roberto Teixeira

; Silva, Eliana Vieira Pinto da

; Carvalho, Valéria Lima

; Martins, Lívia Carício

; Casseb, Samir Mansour Moraes

; Chiang, Jannifer Oliveira

; Vasconcelos, Pedro Fernando da Costa

Memórias do Instituto Oswaldo Cruz

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aug 2012, Volume 107 N. 5 Pages 630 - 636

Abstract: En | Text: En | PDF: En

Rocio virus (ROCV) is an encephalitic flavivirus endemic to Brazil. Experimental flavivirus infections have previously demonstrated a persistent infection and, in this study, we investigated the persistence of ROCV infection in golden hamsters (Mesocricetus auratus). The hamsters were infected intraperitoneally with 9.8 LD50/0.02 mL of ROCV and later anaesthetised and sacrificed at various time points over a 120-day period to collect of blood, urine and organ samples. The viral titres were quantified by real-time-polymerase chain reaction (qRT-PCR). The specimens were used to infect Vero cells and ROCV antigens in the cells were detected by immunefluorescence assay. The levels of antibodies were determined by the haemagglutination inhibition technique. A histopathological examination was performed on the tissues by staining with haematoxylin-eosin and detecting viral antigens by immunohistochemistry (IHC). ROCV induced a strong immune response and was pathogenic in hamsters through neuroinvasion. ROCV was recovered from Vero cells exposed to samples from the viscera, brain, blood, serum and urine and was detected by qRT-PCR in the brain, liver and blood for three months after infection. ROCV induced histopathological changes and the expression of viral antigens, which were detected by IHC in the liver, kidney, lung and brain up to four months after infection. These findings show that ROCV is pathogenic to golden hamsters and has the capacity to cause persistent infection in animals after intraperitoneal infection.

2841 downloads

Eco-epidemiologia dos arbovírus na área de influência da rodovia Cuiabá-Santarém (BR 163), Estado do Pará, Brasil
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Nunes, Marcio Roberto Teixeira

; Barbosa, Taciana Fernandes Souza

; Casseb, Lívia Medeiros Neves

; Nunes Neto, Joaquim Pinto

; Segura, Nazaré de Oliveira

; Monteiro, Hamilton Antônio de Oliveira

; Pinto, Eliana Vieira

; Casseb, Samir Mansour

; Chiang, Jannifer de Oliveira

; Martins, Lívia Caricio

; Medeiros, Daniele Barbosa de Almeida

; Vasconcelos, Pedro Fernando da Costa

Cadernos de Saúde Pública

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dec 2009, Volume 25 N. 12 Pages 2583 - 2602

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo descreve os aspectos eco-epidemiológicos sobre arbovírus nos Municípios de Novo Progresso e Trairão, Estado do Pará, Brasil, na área de influência da BR 163. Anticorpos IH foram detectados para diferentes arbovírus, com reações monotípicas para os VMAY e VORO, dois importantes arbovírus associados a epidemias na Amazônia. Anticorpos IgM para o VORO e VMAY foram detectados em soros humanos, sugerindo infecção recente por esses arbovírus. Duas cepas do VDEN-3 foram isoladas de pacientes febris residentes em Novo Progresso e identificadas como genótipo III. Em termos gerais, os dados obtidos sugerem uma área propícia para a circulação e manutenção de arbovírus e uma população pouco imunizada. Portanto, é importante um monitoramento dinâmico das populações locais e de imigrantes e de animais silvestres quanto à presença de anticorpos e isolamentos de arbovírus, o que permitirá um efetivo controle das infecções por esses agentes virais em residentes da área da rodovia dentro do território paraense.

The current study describes the eco-epidemiological aspects of arbovirus diseases in the municipalities (counties) of Novo Progresso and Trairão, Para State, Brazil, in the area affected by highway BR-163. Hemagglutination inhibition (HI) antibodies to different arboviruses were detected, with monotypic reactions to MAYV and OROV, two important arboviruses associated with epidemics in the Amazon. IgM antibodies to OROV and MAYV were found in human sera, suggesting recent infections by these viruses. Two DENV-3 strains were isolated from febrile patients in Novo Progresso and identified as genotype III strains. In general, the data suggest that the area displays ideal conditions for maintenance and circulation of arboviruses, plus a population with low immunization levels. Dynamic surveillance of local immigrants and wild animals is thus important, focusing on antibody prevalence and isolation of arboviruses, thereby allowing effective control of infections by these viral agents in the resident population along highway BR-163 in Pará State.

5829 downloads

Eco-epidemiologia dos arbovírus na área de influência da rodovia Cuiabá-Santarém (BR 163), Estado do Pará, Brasil
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Nunes, Marcio Roberto Teixeira

; Barbosa, Taciana Fernandes Souza

; Casseb, Lívia Medeiros Neves

; Nunes Neto, Joaquim Pinto

; Segura, Nazaré de Oliveira

; Monteiro, Hamilton Antônio de Oliveira

; Pinto, Eliana Vieira

; Casseb, Samir Mansour

; Chiang, Jannifer de Oliveira

; Martins, Lívia Caricio

; Medeiros, Daniele Barbosa de Almeida

; Vasconcelos, Pedro Fernando da Costa

Cadernos de Saúde Pública

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dec 2009, Volume 25 N. 12 Pages 2583 - 2602

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

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