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Study of Manganese Laurate as Adsorbing Matrix for Undecan-2-one: Factors Affecting Adsorption for Application in Controlled-Release of Pheromones
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Carvalho, Anderson N. de

; Fonseca, Mirelly A. V.

; Vidal, Diogo M.

; Cursino, Ana C. T.

; Firak, Daniele S.

; Lisboa, Fábio S.

Journal of the Brazilian Chemical Society

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jul 2023, Volume 34 N. 7 Pages 967 - 975

Abstract: En | Text: En | PDF: En

One of the greatest challenges faced by agriculture is the use of agrochemicals and the balance between food production and environmental problems associated with the excessive use of these substances. To overcome this issue, pheromones have been used to trap pests that harm crops. This work reports the use of a layered monocarboxylate, manganese laurate (MnL2), as adsorbing matrix for undecan-2-one (methyl nonyl ketone (MNK)), one of the components of the pheromone of the insect Lobiopa insularis, which is a pest in the strawberry cultivar. The manganese laurate was synthesized by a coprecipitation method and was later characterized using X-ray diffractometry, vibrational spectroscopy, thermogravimetric analysis, and differential scanning calorimetry. The characterization techniques showed that MNK was adsorbed in the manganese laurate structure in a range of 0.08 to 1.13 mg g-1, and this interaction was investigated in a factorial design experiment, in which the variables temperature, time of contact, and matrix:MNK ratio were investigated. A negative effect of increasing temperatures was observed and attributed to substrate volatilization. The adsorption was favored in increasing molar ratios and times of contact, and ideal conditions for the adsorption could be found, indicating that manganese laurate could be applied in controlled-release tests.

https://doi.org/10.21577/0103-5053.20230009

The Use of Single Crystal X-ray Diffraction Technique for Characterization of 25I-NBOMe and 25R-NBOH (R = Cl, I, Br, Et) in Forensic Application
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Lucena, Maria C. C.

; Lopes, Karen P. S.

; Ayala, Alejandro P.

; Vidal, Laura M. T.

; Lopes, Thiago I. B.

; Ricardo, Nágila M. P. S.

Journal of the Brazilian Chemical Society

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may 2023, Volume 34 N. 5 Pages 641 - 652

Abstract: En | Text: En | PDF: En

Criminal minds create new psychoactive substances (NPS) to dribble the Drug Regulatory System. Early Warning Systems (EWA) were instituted worldwide to combat this practice. Brazilian government has started establishing EWA at a national level since August 2021. The role of drug analysis laboratories in EWA is very important and experts working at forensic laboratories are in the main position to detect NPS and any changes in the molecular structures. However, for this practice, it is necessary to use reliable analyses techniques for unequivocal identification. The goal of this work is to use single-crystal X-ray diffraction (XRD) to detect the presence of NPS and elucidate its molecular structure using single crystals from a seized blotter paper. XRD is also useful to prepare reference substances to produce entries to be included in Fourier transformed infrared spectroscopy (FTIR) and mass spectrometry databases, which are some of the most relevant routine techniques in forensic laboratories. This approach was used to study the NPS 25R-NBOH and 25I-NBOMe using XRD, FTIR, Raman, and nuclear magnetic resonance spectroscopies. The results showed that molecular structure methods must be used to elucidate NPS in an unambiguous manner and the potential of XRD use in the forensic area as a reference method.

https://doi.org/10.21577/0103-5053.20220130

Influence of garlic extract on larval performance and survival of juvenile angelfish Pterophyllum scalare during transport
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Mattos, D. C.

; Manhães, J. V. A.

; Cardoso, L. D.

; Aride, P. H. R.

; Lavander, H. D.

; Oliveira, A. T.

; Radael, M. C.

; Azevedo, R. V.

; Vidal Junior, M. V.

Brazilian Journal of Biology

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2023, Volume 83 elocation e244480

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O estudo teve como objetivo avaliar as propriedades do alho como promotor de crescimento em larvas de acará bandeira Pterophyllum scalare e seus benefícios no transporte de juvenis da mesma espécie. O experimento foi conduzido em sistema de recirculação composto por 20 aquários de 40 L de volume útil, dotado de entrada e saída de água independentes e teve a duração de 40 dias. O delineamento experimental adotado foi o inteiramente casualizado (DIC), com cinco tratamentos e quatro repetições, totalizando 20 unidades experimentais. Foram utilizadas 1.400 larvas de acará bandeira (Pterophyllum scalare) divididas entre os tratamentos. Os tratamentos consistiram em: 0, 50, 100, 200 e 400 mg de extrato de alho por quilo de ração. Os resultados mostraram que não houve efeito significativo dos níveis de inclusão do extrato do alho sobre os índices zootécnicos avaliados e posteriormente no transporte dos juvenis. Também não foi observado influência na sobrevivência das larvas durante o período experimental. Novas pesquisas com dosagens maiores de extratos devem ser realizados para melhor elucidação do efeito do extrato de alho como promotor de crescimento.

Abstract The objective of this study was to evaluate the properties of garlic as a growth promoter in larvae of angelfish Pterophyllum scalare and its benefits during transport of juveniles of this species. The experiment was conducted in recirculation aquaculture system, consisting of 20 tanks of 40 L equipped with independent water input and output. We used 1,400 larvae distributed among five treatments, with four repetitions, which totaled 20 experimental units. The treatments were 0, 50, 100, 200, and 400 mg of garlic extract per kilo of feed. The results showed that the inclusion of levels of garlic extract in the feed did not significantly effect the fish’s development or their transport. Neither did the inclusion of levels of garlic extract affect the survival of the larvae during the trial period. New research with extracts of higher dosages should be performed to elucidate the effect of garlic extract as a growth promoter.

https://doi.org/10.1590/1519-6984.244480 241 downloads

Use of inhibitors and protectors in the tolerance of white oat cultivars to the penoxsulam herbicide
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Xavier, Elouize

; Trezzi, Michelangelo M.

; Oliveira, Marisa de C.

; Vidal, Ribas A.

Advances in Weed Science

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2023, Volume 41 elocation e020200013

Abstract: En | Text: En | PDF: En

Abstract Background Crop tolerance to herbicides and the effectiveness of weed control are key considerations of a chemical management program. Crop tolerance levels and the mechanism involved is of great importance in ensuring the safe use of an herbicide. Objective This study aims to evaluate the effect of mefenpyr-diethyl as a safener and metabolic inhibitor (organophosphorus insecticides) on the penoxsulam tolerance of white oat cultivars. Methods We determined the relative tolerance (%) of URS Guará and URS Guria white oat cultivars to different doses of penoxsulam with and without prior application of organophosphorus metabolic inhibitors (malathion + chlorpyrifos). We then determined the relative tolerance (%) of the white oat cultivar URS Guria with and without prior application of a protective metabolization stimulator (mefenpyr-diethyl). Results Increased penoxsulam doses resulted in lower relative tolerance of both cultivars. The application of organophosphorus insecticides reduced the penoxsulam tolerance of white oat cultivars, with a 14.4 and 4.8 fold reduction of C50 in the URS Guará and URS Guria cultivars, respectively. The use of mefenpyr-diethyl increased the penoxsulam tolerance of URS Guria by a factor of 2.62. Conclusions The penoxsulam tolerance of white oat cultivars was reduced by organophosphorus insecticides and increased by mefenpyr-diethyl. Metabolization is the likely mechanism of tolerance of white oats to this herbicide.

https://doi.org/10.51694/advweedsci/2023;41:00006

Effect of temperature on embryonic development and first exogenous feeding of goldfish Carassius auratus (Linnaeus, 1758)
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Motta, J. H. S.

; Glória, L. S.

; Radael, M. C.

; Mattos, D. C.

; Cardoso, L. D.

; Vidal-Júnior, M. V.

Brazilian Journal of Biology

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2023, Volume 83 elocation e270943

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Goldfish or Kinguio is a widely marketed species worldwide due to the ornamental market. There is some lack of acknowledgment of the production of the species under specific climatic conditions. To evaluate the effect of temperature on embryonic development and the first exogenous feeding of goldfish, an experiment was proposed. Fifteen incubators, organized in five treatments (18, 22, 26, 30, and 34 °C) with three replications each, were used to keep the fertilized goldfish eggs until the first exogenous feeding of the larvae. The main development events were observed to understand the possible effects of these temperatures on embryos and larvae of the species. Temperature influences embryo development and the time of first exogenous feeding of goldfish. The temperature of 34 °C was lethal to the species causing 100% of anomalies in the embryos and larvae. The experiment data allow us to conclude that the species presents a maximum thermal limit during embryogenesis, and these data are important to the aquaculture industry and to understand the effect of climate changes on goldfish. The data obtained in this experiment will assist in the management of invasive species and production of the species (aquaculture).

Resumo O peixe dourado ou Kinguio é uma espécie amplamente comercializada em todo o mundo devido ao mercado ornamental. Existe alguma falta de conhecimento da produção da espécie em condições climáticas específicas. Para avaliar o efeito da temperatura no desenvolvimento embrionário e na primeira alimentação exógena do Kinguio, um experimento foi proposto. Quinze incubadoras, organizadas em cinco tratamentos (18, 22, 26, 30 e 34 °C) com três repetições cada, foram utilizadas para manter os ovos fertilizados de Kinguio até a primeira alimentação exógena das larvas. Os principais eventos do desenvolvimento foram observados para entender os possíveis efeitos dessas temperaturas em embriões e larvas da espécie. A temperatura influencia o desenvolvimento do embrião e o tempo da primeira alimentação exógena do Kinguio. A temperatura de 34°C foi letal para a espécie causando 100% de anomalias nos embriões e larvas. Os dados do experimento permitem concluir que a espécie apresenta um limite térmico máximo durante a embriogênese, sendo esses dados importantes para a indústria da aquicultura e para entender o efeito das mudanças climáticas no Kinguio. Os dados obtidos neste experimento auxiliarão no manejo de espécies invasoras e na produção da espécie (aquicultura).

https://doi.org/10.1590/1519-6984.270943

Selective weed control in white oat cultivars with als-inhibiting herbicides
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Xavier, Elouize

; Trezzi, Michelangelo M.

; Oliveira, Marisa de C.

; Vidal, Ribas A.

Advances in Weed Science

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2022, Volume 40 elocation e0220237088

Abstract: En | Text: En | PDF: En

Abstract Background The limited number of selective herbicides for white oat (Avena sativa L.) cultivation makes it managing weeds a challenge. Currently, few herbicide options are available for selective weed control in winter crops. Previous studies have indicated that ALS-inhibiting herbicides could be potential alternatives, so studies were conducted. Objective To characterize the tolerance level of white oat cultivars to ALS-inhibiting herbicides and to evaluate the level of weed control by applying penoxsulam and bispyribac-sodium. Methods Tolerance (%) was determined for white oat cultivars UFRGS 14, URS Guará, URS Guria, UFRGS 18, and URS Taura for imazethapyr, iodosulfuron, penoxsulam, and bispyribac-sodium dose-response. Also, the control efficiency of different doses of penoxsulam and bispyribac-sodium was determined on weed species of white oat, namely crabgrass (Digitaria horizontalis), siberian motherwort (Leonurus sibiricus), italian ryegrass (Lolium multiflorum), and wild radish (Raphanus raphanistrum). Results Imazethapyr and bispyribac-sodium were the least selective herbicides, whereas iodosulfuron had intermediate selectivity, and penoxsulam was the most selective for the white oat cultivars tested, with average control of 100, 72, 62.7 and 40%, respectively. Overall, bispyribac-sodium had a higher level of weed control (77.1%) than penoxsulam (62%). Label doses of penoxsulam and bispyribac-sodium resulted in low control levels of crabgrass. Conclusions All doses of bispyribac-sodium effectively control wild radish and italian ryegrass. The recommended dose of penoxsulam was selective for some cultivars of white oat and effectively controlled italian ryegrass and wild radish.

https://doi.org/10.51694/advweedsci/2022;40:00004

Primer registro de nematodos zoonóticos de transmisión alimentaria (Nematoda: Anisakidae) en músculo de Cynoscion guatucupa (pescadilla de calada) y Macrodon ancylodon (pescadilla de red) comercializado en Uruguay
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Crosi Martínez, Gonzalo

; García, Federico

; Viera, Gerardo

; Correa, Ivette

; Martínez, Valentina

; Pizzorno, Pablo

; Vidal, Gustavo

; Galli, Carina

; Trujillo, Lucía

; Díaz, Santiago

; Friss de Kereki, Cristina

; Dragonetti, José Pedro

; Armúa Fernánde, María Teresa

Revista FAVE. Sección Ciencias veterinarias

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2022, Volume 21 elocation e0009

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen En los últimos 4 años, Uruguay ha experimentado una creciente demanda por el consumo de alimentos a base de pescado crudo, tales como sushi, sashimi y ceviche. Este escenario generó la necesidad de evaluar la presencia y concentración de parásitos zoonóticos (Nematoda: Anisakidae) en porciones comestibles de especies de pescado comercializadas en el mercado local. Se analizaron 233 ejemplares de tres especies de pescado comercializadas en Uruguay: Macrodon ancylodon, Micropogonias furnieri y Cynoscion guatucupa. Se cuantificaron e identificaron, a nivel de género, nematodos en cavidad celómica y músculo, estableciendo finalmente los descriptores ecológicos para cada género encontrado y para cada especie de pescado evaluada. Dos de las especies evaluadas se encontraban parasitadas a nivel de cavidad celómica y tejido muscular, M. ancylodon y C. guatucupa. Cynoscion guatucupa resultó la especie mayormente parasitada con una prevalencia de 46%, mientras que el género de anisákido más prevalente fue Contracaecum (prevalencia de 35,1% en C. guatucupa y 32,4% en M. ancylodon). El hallazgo de anisákidos en la especie M. ancylodon representa un nuevo registro de hospedador en Uruguay. Por otra parte, se reporta por primera vez en el país la presencia de estos parásitos zoonóticos en porciones comestibles (músculo).

Abstract In the last 4 years, Uruguay has experienced a growing demand of raw fish-based foods, such as sushi, sahimi and ceviche. This scenario generated the need to assess the presence and concentration of zoonotic parasites (Nematodoes: Anisakidae) in edible parts of fish species traded in the local market. 233 fish specimens of 3 species commercialized in Uruguay were analyzed: Macrodon ancylodon, Micropogonias furnieri and Cynoscion guatucupa. The nematodes were quantified and identified at genus level, from coelomic cavity and muscle of the fishes, to finally stablish the ecological descriptors for each genus founded and for each fish species evaluated. Two of the three species of fish were parasitized with anisakids in both location (coelomic cavity and muscle), M. ancylodon and C. guatucupa. C. guatucupa was the most parasitized with a prevalence of 46%, while, the anisakid genus most prevalente was Contracaecum (prevalence of 35,1% in C. guatucupa and 32,4% in M. ancylodon). The finding of anisakids in M. ancylodon represents a report of a new host in Uruguay. Moreover, the finding for the first time in the country of these zoonotic parasites in edible parts of fish (muscle) is highlighted.

https://doi.org/10.14409/favecv.2022.0.e0009

Zootechnical indices and digestibility in juveniles of tambaqui Colossoma macropomum fed a diet containing particulate maize
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Polese, M. F.

; Polese, M. F.

; Radael, M. C.

; Mendonça, P. P.

; Motta, J. H. S.

; Azevedo, R. V.

; Souza, A. B.

; Shimoda, E.

; Lavander, H. D.

; Aride, P. H. R.

; Oliveira, A. T.

; Vidal Júnior, M. V.

Brazilian Journal of Biology

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2022, Volume 82 elocation e232612

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Três experimentos foram realizados com diferentes tamanhos de partícula de ração para o desempenho zootécnico, taxa de aprovação e digestibilidade aparente de tambaqui juvenil (Colossoma macropomum). No primeiro, foram utilizados 200 juvenis e distribuídos em 20 tanques (220 L), 10 peixes por unidade (quatro repetições). O sistema experimental utilizado para registrar o tempo de passagem foi composto por cinco incubadoras com 200 L. No segundo, 75 juvenis foram utilizados por 55 dias (três repetições). No terceiro, 75 juvenis foram utilizados e distribuídos em cinco incubadoras de 200 L. Todos os experimentos foram realizados aleatoriamente. Diferentes tratamentos de comportamento linear foram observados para digestibilidade aparente da proteína bruta; e o menor tamanho de partícula (150 μm) apresentou melhor digestibilidade dos resultados. menor tamanho de partícula do milho apresentou melhores resultados, afetou o desempenho de crescimento de tambaquis e a digestibilidade aparente da proteína bruta e extrato etéreo. Portanto, recomenda-se o uso de um tamanho de partícula de 150 μm de milho para o tambaqui.

Abstract Three experiments were done with different particle sizes of corn feed on its zootechnical performance, passing rate and apparent digestibility of juvenile tambaqui (Colossoma macropomum). In the first, 200 juveniles were used and distributed in 20 tanks (220 L), 10 fish per unit (four replicates). The experimental system used to record passage time was composed of five incubators with 200 L. In the second, 75 juveniles were used per 55 days (three replications). In the third, 75 juveniles were used and distributed in five incubators of 200 L. All experiments were performed randomly. Different linear behavior treatments were observed for apparent digestibility of crude protein; and the smaller particle size (150 μm) had better results digestibility. smaller particle size of the corn had better results, affected the growth performance of tambaqui and the apparent digestibility of crude protein and ether extract. Thus, is recommended that a particle size of 150 μm of corn be used for tambaqui.

https://doi.org/10.1590/1519-6984.232612 187 downloads

Nanopartículas de quitosano mejoran la calidad nutracéutica de germinados de triticale
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Ramírez Rodríguez, Silvia C.

; Ortega Ortiz, Hortensia

; Fortis Hernández, Manuel

; Nava Santos, Juan M.

; Orozco Vidal, Jorge A.

; Preciado Rangel, Pablo

Revista mexicana de ciencias agrícolas

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jun 2021, Volume 12 N. 4 Pages 579 - 589

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The use of chitosan nanoparticles (NPs CS) has become a promising alternative in modern agriculture as an inducer in the biosynthesis of secondary metabolites. The objective of this research was to evaluate the effect of NPs CS on the nutraceutical quality of triticale sprouts (x Triticosecale Wittmack). Increasing doses of NPs Cs: 0, 0.1, 0.2, 0.4 and 0.8 mg ml-1 were applied only once at the imbibition stage, then they were left in Petri dishes for 7 days at 25 ±2 °C temperature. NPs CS did not affect germination or fresh root weight at the tested concentrations, and the concentration of 0.1 mg ml-1 increased the fresh weight of the shoots up to 83.3%. In the presence of 0.8 mg ml-1 of NPs CS phenolic compounds decrease by 7% and flavonoids increase by 29%. The results confirm a promoter effect of NPS CS on sprouts, opening the possibility of being used as inducers in the biosynthesis of bioactive compounds in triticale sprouts.

Resumen El uso de nanopartículas de quitosán (NPs CS) se ha vuelto una alternativa prometedora en la agricultura moderna como un inductor en la biosíntesis de metabolitos secundarios. El objetivo del presente trabajo fue evaluar el efecto de NPs CS en la calidad nutraceútica de germinados de triticale (x Triticosecale Wittmack). Dosis creciente de NPs CS: 0, 0.1, 0.2, 0.4 y 0.8 mg ml-1 se aplicaron una sola vez en la etapa de imbibición, después se dejaron en cajas Petri durante 7 días a 25 ±2 °C de temperatura. Las NPs CS no afectaron la germinación ni el peso freso de la raíz a las concentraciones probadas, y a la concentración de 0.1 mg ml-1 aumentó el peso fresco del brote hasta 83.3%. En presencia de 0.8 mg ml-1 de las NPs CS los compuestos fenólicos disminuyen un 7% y aumentan 29% los flavonoides. Los resultados confirman un efecto promotor de las NPS CS en los germinados, abriendo la posibilidad de ser utilizadas como inductores en la biosíntesis de compuestos bioactivos en germinados de triticale.

https://doi.org/10.29312/remexca.v12i4.2929 27 downloads

10.

Isolation of 27 polymorphic nuclear microsatellite markers for Roupala montana var. brasiliensis (Proteaceae)
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PEREIRA, FERNANDA B.

; SEBBENN, ALEXANDRE M.

; ROSSINI, BRUNO C.

; MELCHERT, GUILHERME F.

; MARINO, CELSO L.

; RIBOLLA, PAULO E.M.

; ALONSO, DIEGO P.

; VIDAL, EDSON

; TAMBARUSSI, EVANDRO V.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 N. 2 elocation e20200452

Abstract: En | Text: En | PDF: En

Abstract Microsatellite primers pairs were developed for the Neotropical tree Roupala montana var. brasiliensis for use in studies on genetic diversity, mating system, and gene flow. Forty-two primer pairs were developed, resulting in 27 polymorphic loci, with two to 27 alleles per locus. The primer pairs were validated against 34 R. montana var. brasiliensis adult trees from four populations. The observed (H o) and expected (H e)heterozygosities ranged among loci from 0.061 to 0.930 (mean of 0.544) and from 0.116 to 0.950 (mean of 0.700), respectively. Null alleles were observed for ten loci. No genotypic linkage disequilibrium was detected in any pair of loci. This set of loci is suitable for population genetic studies of the species.

https://doi.org/10.1590/0001-3765202120200452 118 downloads

11.

Multiresidue Determination of Endocrine Disrupting Compounds in Sewage Treatment Plants (SPE-HPLC-DAD)
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Vidal, Carla B.

; Barbosa, Pablo G. A.

; Pessoa, Germana P.

; Buarque, Patrícia C.

; Nascimento, José G. S.

; Farias Filho, Antônio L.

; Paz, Mário S.

; Santos, André B. dos

; Cavalcante, Rivelino M.

; Nascimento, Ronaldo F.

Journal of the Brazilian Chemical Society

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dec 2020, Volume 31 N. 12 Pages 2518 - 2530

Abstract: En | Text: En | PDF: En

This work focuses on the validation and application of solid phase extraction followed by high-performance liquid chromatography (SPE-HPLC) analysis of important endocrine disruptors compounds (EDC) from different classes in highly complex wastewater matrix. The endocrine disruptors investigated included three different categories: pharmaceuticals (sulfamethoxazole (SMZ), trimethoprim (TMP) and diclofenac (DCF)), hormones (estrone (E1), 17α-ethinylestradiol (EE2) and 17β-estradiol (E2)) and plastic materials (bisphenol A (BPA)). The method involves pre-concentration by SPE using Strata-X extraction cartridges followed by HPLC coupled with diode array detector (DAD). As the assumption of homoscedasticity was met for analytical data, ordinary linear regression procedure was applied to the data. The method was considered validated for 7 EDC after consistent evaluation of the key analytical parameters. Recoveries were ranged from 52.3 to 179.6%. Limits of quantification were in the range 6.0-0.4 µg L−1. The described method was applied to evaluate the occurrence and removal efficiency of EDC in two biological sewage treatment plants (STPs). The influent mean concentrations of E1, E2 and EE2 hormones were 79.54; 175.09 and 102.19 µg L−1, respectively, while for SMZ, TMP, DCF and BPA were 215.17; 187.01; 218.97 and 87.12 µg L−1 for STP A, respectively. The efficiencies for the removal of EDCs ranged from 0 to 79.4%.

https://doi.org/10.21577/0103-5053.20200127 266 downloads

12.

Metodología para la elaboración de la Guía de práctica clínica
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Torres-Tamayo, Margarita

; Zurita-Cruz, Jessie N.

; Aguilar-Herrera, Blanca E.

; Miranda-Lora, América L.

; Calzada-León, Raúl

; Rivera-Hernández, Aleida J.

; Morales-Pérez, Marco A.

; Padrón-Martínez, Miriam M.

; Ruiz-Reyes, María L.

; García-Morales, Leticia M.

; Barrón-Uribe, Consuelo

; Arguinzoniz-Valenzuela, Sletza L.

; Torres-Castañeda, Mayra C.

; Lizárraga-Paulin, Lorena

; Núñez-Hernández, Jorge A.

; Cornejo-Barrera, Judith

; Vidal-González, María T.

; Martínez-Alvarado, María R.

; Nishimura-Meguro, Elisa

; Bravo-Ríos, Luz E.

; Garrido-Magaña, Eulalia P.

; Orozco-Morales, José A.

; Medina-Bravo, Patricia G.

; Coyote-Estrada, Ninel

; Castilla-Peón, M. Fernanda

Boletín médico del Hospital Infantil de México

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2020, Volume 77 Suppl. 1 Pages 1 - 6

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: The Mexican Society of Pediatric Endocrinology presents recommendations for the diagnosis and treatment of precocious puberty (PP), a condition defined as the development of sexual characteristics due to an increase in pituitary gonadotropin secretion before 8 or 9 years of age in girls and boys, respectively. Methods: Three systematic reviews were conducted: controlled clinical trials on interventions for PP treatment, diagnostic tests, and observational studies on the long-term effects of PP. The quality evaluation and data extraction from the studies were conducted by two independent reviewers. The Scottish Intercollegiate Guidelines Network and the Oxford Center for Evidence-Based Medicine systems were used for grading the quality of evidence for recommendations on intervention and diagnosis, respectively. Recommendations were submitted to a consensus by a Delphi method and were validated by another 143 certified pediatric endocrinologists through an online questionnaire. Results: The group generated 12 recommendations on the diagnosis of PP, seven on the diagnosis of secondary causes of PP, eight on interventions for inhibition of puberty, five on other interventions for PP treatment, and 14 for the monitoring and follow-up of these patients. The online questionnaires submitted to certified pediatric endocrinologists showed more than 90% of approval for each one of the recommendations. Conclusions: Although a high degree of consensus for the recommendations for diagnosis, treatment, and monitoring of PP among pediatric endocrinologists was achieved, most of these recommendations showed a low level of evidence.

Resumen Introducción: La Sociedad Mexicana de Endocrinología Pediátrica presenta recomendaciones para el diagnóstico y el tratamiento de la pubertad precoz (PP), condición definida como el desarrollo de caracteres sexuales por incremento en la secreción hipofisiaria de gonadotropinas antes de los 8 años en las niñas y de los 9 años en los niños. Métodos: Se realizaron tres revisiones sistemáticas de ensayos clínicos controlados sobre intervenciones para el tratamiento de la PP, pruebas diagnósticas y estudios observacionales sobre efectos a largo plazo de la PP. La evaluación de la calidad de los estudios y la extracción de datos se realizó por pares. La evidencia se graduó con el sistema de la Scottish Intercollegiate Guidelines Network (SIGN) y del Oxford Centre for Evidence-Based Medicine (OCEBM) para las recomendaciones sobre la intervención y el diagnóstico, respectivamente. Las recomendaciones generadas se sometieron a un consenso por el método Delphi y fueron validadas por otros 143 endocrinólogos pediatras certificados mediante un cuestionario en línea. Resultados: Mediante consenso se generaron 12 recomendaciones para el diagnóstico de PP, siete sobre diagnóstico de causas secundarias de PP, ocho sobre intervenciones para inhibición de la pubertad, cinco sobre otras intervenciones en PP y 14 para la monitorización del tratamiento y el seguimiento de estos pacientes. Se obtuvo más del 90% de aprobación para cada una de las recomendaciones por el grupo de endocrinólogos certificados que respondieron el cuestionario en línea. Conclusiones: Si bien se logró un alto grado de consenso para las recomendaciones para el diagnóstico, el tratamiento y la monitorización de la PP entre los endocrinólogos pediatras, el nivel de evidencia para la mayoría de estas recomendaciones resultó bajo.

https://doi.org/10.24875/bmhim.20000083 411 downloads

13.

Inhibición de la pubertad
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Torres-Tamayo, Margarita

; Zurita-Cruz, Jessie N.

; Aguilar-Herrera, Blanca E.

; Miranda-Lora, América L.

; Calzada-León, Raúl

; Rivera-Hernández, Aleida J.

; Morales-Pérez, Marco A.

; Padrón-Martínez, Miriam M.

; Ruiz-Reyes, María L.

; García-Morales, Leticia M.

; Barrón-Uribe, Consuelo

; Arguinzoniz-Valenzuela, Sletza L.

; Torres-Castañeda, Mayra C.

; Lizárraga-Paulin, Lorena

; Núñez-Hernández, Jorge A.

; Cornejo-Barrera, Judith

; Vidal-González, María T.

; Martínez-Alvarado, María R.

; Nishimura-Meguro, Elisa

; Bravo-Ríos, Luz E.

; Garrido-Magaña, Eulalia P.

; Orozco-Morales, José A.

; Medina-Bravo, Patricia G.

; Coyote-Estrada, Ninel

; Castilla-Peón, M. Fernanda

Boletín médico del Hospital Infantil de México

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2020, Volume 77 Suppl. 1 Pages 19 - 25

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The Mexican Society of Pediatric Endocrinology developed a clinical practice guide for the diagnosis and treatment of precocious puberty. This document presents recommendations related to the interventions for the inhibition of central precocious puberty. The detailed description of the methodology for the development of this guide and the grading system, as well as the synthesis of the evidence on which it is based can be consulted in this same supplement.

Resumen La Sociedad Mexicana de Endocrinología Pediátrica elaboró una guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz. Este documento presenta recomendaciones relacionadas con las intervenciones para inhibir la pubertad precoz central. La descripción detallada de la metodología para el desarrollo de esta guía y del sistema de gradación, así como la síntesis de la evidencia en la que se basa, pueden consultarse en este mismo suplemento.

https://doi.org/10.24875/bmhim.20000085 455 downloads

14.

Diagnóstico de pubertad precoz
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Miranda-Lora, América L.

; Torres-Tamayo, Margarita

; Zurita-Cruz, Jessie N.

; Aguilar-Herrera, Blanca E.

; Calzada-León, Raúl

; Rivera-Hernández, Aleida J.

; Morales-Pérez, Marco A.

; Padrón-Martínez, Miriam M.

; Ruiz-Reyes, María L.

; García-Morales, Leticia M.

; Barrón-Uribe, Consuelo

; Arguinzoniz-Valenzuela, Sletza L.

; Torres-Castañeda, Mayra C.

; Lizárraga-Paulin, Lorena

; Núñez-Hernández, Jorge A.

; Cornejo-Barrera, Judith

; Vidal-González, María T.

; Martínez-Alvarado, María R.

; Nishimura-Meguro, Elisa

; Bravo-Ríos, Luz E.

; Garrido-Magaña, Eulalia P.

; Orozco-Morales, José A.

; Medina-Bravo, Patricia G.

; Coyote-Estrada, Ninel

; Castilla-Peón, M. Fernanda

Boletín médico del Hospital Infantil de México

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2020, Volume 77 Suppl. 1 Pages 7 - 14

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The Mexican Society of Pediatric Endocrinology developed a clinical practice guide for the diagnosis and treatment of precocious puberty. This document presents recommendations related to the diagnosis of precocious puberty. The detailed description of the methodology for the development of this guide and the grading system, as well as the synthesis of the evidence on which it is based can be accessed in this same supplement.

Resumen La Sociedad Mexicana de Endocrinología Pediátrica elaboró una guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz. Este documento presenta recomendaciones relacionadas con el diagnóstico de pubertad precoz. La descripción detallada de la metodología para el desarrollo de esta guía y del sistema de gradación, así como la síntesis de la evidencia en la que se basa, pueden consultarse en este suplemento.

https://doi.org/10.24875/bmhim.20000075 1249 downloads

15.

Diagnóstico de causas secundarias de pubertad precoz
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Metrics
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Torres-Tamayo, Margarita

; Calzada-León, Raúl

; Rivera-Hernández, Aleida J.

; Zurita-Cruz, Jessie N.

; Aguilar-Herrera, Blanca E.

; Miranda-Lora, América L.

; Morales-Pérez, Marco A.

; Padrón-Martínez, Miriam M.

; Ruiz-Reyes, María L.

; García-Morales, Leticia M.

; Barrón-Uribe, Consuelo

; Arguinzoniz-Valenzuela, Sletza L.

; Torres-Castañeda, Mayra C.

; Lizárraga-Paulin, Lorena

; Núñez-Hernández, Jorge A.

; Cornejo-Barrera, Judith

; Vidal-González, María T.

; Martínez-Alvarado, María R.

; Nishimura-Meguro, Elisa

; Bravo-Ríos, Luz E.

; Garrido-Magaña, Eulalia P.

; Orozco-Morales, José A.

; Medina-Bravo, Patricia G.

; Coyote-Estrada, Ninel

; Castilla-Peón, M. Fernanda

Boletín médico del Hospital Infantil de México

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2020, Volume 77 Suppl. 1 Pages 15 - 18

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The Mexican Society of Pediatric Endocrinology developed a clinical practice guide for the diagnosis and treatment of precocious puberty. This document presents recommendations related to the diagnosis of secondary causes of central PP. The detailed description of the methodology for the development of this guide and the grading system, as well as the synthesis of the evidence on which it is based can be consulted in this same supplement.

Resumen La Sociedad Mexicana de Endocrinología Pediátrica elaboró una guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz. Este documento presenta recomendaciones relacionadas con el diagnóstico de causas secundarias de pubertad precoz central. La descripción detallada de la metodología para el desarrollo de esta guía y del sistema de gradación, así como la síntesis de la evidencia en la que se basa, pueden consultarse en este mismo suplemento.

https://doi.org/10.24875/bmhim.20000084 279 downloads

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