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Abstract Healthcare workers present an increased risk of contagion for the SARS-CoV-2 virus due to their labor exposure. Here, we describe the clinical, laboratory, and immunological characteristics of healthcare workers, before vaccine application, exposed to SARS-CoV-2-infected patients. We collected sociodemographic, clinical, and laboratory information from 50 professionals who worked during the COVID-19 pandemic at the Clinical Hospital of the Northwest in Brazil. The results showed that most workers are women, over 50 years old, and worked as nursing technicians. Approximately 56% of workers were positive for a previous infection by RT-PCR and/or anti-SARS-CoV-2-immunoglobulin tests. Increased levels of hematocrit, neutrophils, NK lymphocytes, and fibrinogen, were found in positive healthcare workers, suggesting a light inflammatory status. The immunological findings showed an increase in IL-17 production and a Th2/Th17/Th22 profile followed by high serology for anti-SARS-CoV-2 IgM and IgG. Those data reveal the importance of studies with healthcare workers to investigate if the continuous exposition to the virus may result in chronic activation of the immune system and/or pulmonary inflammation in this target group.

https://doi.org/10.1590/0001-3765202320220502

Agrobacterium rhizogenes-Mediated Transformation of Crotalaria ochroleuca: Production of Flavonoids from Hairy Roots
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Blank, Daiane E.

; Demuner, Antonio J.

; Carvalho, Jilma L. B.

; Firmino, Maria J. M.

; Figueiredo, Tainá S.

; Souza, Gustavo S. F.

; Zocolo, Guilherme J.

; Guedes, Jhonyson A. C.

; Faria, Daniele V.

; Vieira, Lorena M.

; Soares, Jéssica R.

; Fortini, Evandro A.

; Santos, Marcia A. C.

; Otoni, Wagner C.

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 12 Pages 1898 - 1908

Abstract: En | Text: En | PDF: En

Crotalaria ochroleuca (Fabaceae) is rich in bioactive compounds used for nematode control. Transformed root culture allows the production of a large amount of hairy root biomass, conditioned by auxin biosynthesis-related genes integrated via the process of Agrobacterium rhizogenes infection, which is known to cause a hairy root phenotype. We transformed A. rhizogenes to increase the biomass of hairy roots and optimized the process of production of bioactive compounds. The transformed nature of hairy roots was confirmed by polymerase chain reaction, which confers kanamycin resistance. The transformed roots were cultured in full-strength in liquid media to realize the growth of hairy roots and the production of bioactive compounds. The transformed roots were grown in a culture medium supplemented with elicitors to produce total phenols, and flavonoids. Chromatographic analysis of transformed roots revealed the presence of flavonoids apigenin-6,8-C-diglucoside and luteolin-6-C-glucoside. The results were obtained by conducting physiological and biochemical studies with the Flavonoids and studying the pathways that led to the production of large amounts of bioactive compounds from the hairy roots of C. ochroleuca. It was observed that the extraction of the compounds significantly affected nematodes and insect larvae, resulting in significantly high levels of economic damage to crops.

https://doi.org/10.21577/0103-5053.20230083

Biologically Active Volatile Organic Compounds (VOCs) Produced by Rhizospheric Actinobacteria Strains Inhibit the Growth of the Phytopathogen Colletotrichum musae
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Brito, Maria V. de

; Fonseca, Wéverson L.

; Mafezoli, Jair

; Barbosa, Francisco G.

; Nunes, Fátima M.

; Mattos, Marcos C. de

; Santos, João E. A. dos

; Araujo, Francisca S. A.

; Vieira, Regimara F. B. S.

; Magalhães, Hilton C. R.

; Muniz, Celli R.

; Garruti, Deborah S.

; Ootani, Marcio A.

; Souza Netto, José M.

; Pinto, Licarion

; Viana, Francisco M. P.

; Oliveira, Maria C. F.

Journal of the Brazilian Chemical Society

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oct 2022, Volume 33 N. 10 Pages 1172 - 1189

Abstract: En | Text: En | PDF: En

The antifungal potential of volatile organic compounds (VOCs) produced by actinobacterial strains Streptomyces sp. (ACTB-77) and Amycolatopsis sp. (ACTB-290) from the rhizosphere of Caatinga plants against Colletotrichum musae was investigated. VOCs produced by these microorganisms (axenic and co-culture) were investigated using headspace-solid phase micro-extraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS). Although no exclusive VOC peaks were observed in the co-culture with ACTB-77, the same experiment involving ACTB-290 yielded five new peaks, including two identified alcohols, suggested as bioreductive products of the corresponding ketones by the fungus. Statistical analysis revealed that co-culture ACTB-77/C. musae has a closer similarity to the fungus than to the actinobacteria, while the co culture ACTB-290/C. musae showed closer similarity to the actinobacteria. These confirmed the more pronounced antifungal activity of the ACTB-290 strain, as observed in the fungus growth inhibition experiments. The antifungal activity of ACTB-290 was associated to its sulfur-containing metabolites, while linalool was suggested as responsible for the ACTB-77 activity.

https://doi.org/10.21577/0103-5053.20220037

Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac)
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SOUZA-SILVA, GUILHERME ANTONIO DE

; AQUINO, RODRIGO CESAR A. DE

; SOUSA, GEORON F. DE

; BARROS, BÁRBARA RAFAELA S.

; LIMA, MARÍLLIA RAPHAELLA C.F. DE

; CRUZ, LEONARDO C.O.

; MARCOS, BIANCA F. SÃO

; SILVA, ANNA JÉSSICA D.

; TALES, APARECIDA VIRGÍNIA S.

; DINIZ, MADI V.

; LIMA, MÔNICA MARIA C.

; SÁ, IGOR W.A. DE

; RODRIGUES, FÁBIO AUGUSTO C.

; SOUZA, EDSON B. DE

; NASCIMENTO, ARIONE V. DO

; VIEIRA, AMANDA M.

; CARVALHO, BRUNO M. DE

; CAMPELO JÚNIOR, EVÔNIO B.

; FREITAS, ANTONIO CARLOS DE

; MELO, CRISTIANE M.L. DE

Anais da Academia Brasileira de Ciências

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2022, Volume 94 N. 3 elocation e20211590

Abstract: En | Text: En | PDF: En

Abstract Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.

https://doi.org/10.1590/0001-3765202220211590

Impact of bariatric surgery in elderly patients with obesity
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PEREIRA, ADRIANO F.

; SANTA-CRUZ, FERNANDO

; COUTINHO, LUCAS R.

; VIEIRA-DE-MELO, MARIA CLARA P. T.

; HINRICHSEN, EDUARDA A.

; SIQUEIRA, LUCIANA T.

; FIGUEIREDO, JOSÉ-LUIZ

; FERRAZ, ÁLVARO A. B.

Revista do Colégio Brasileiro de Cirurgiões

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2022, Volume 49 elocation e20223299

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: avaliar o impacto da cirurgia bariátrica na população idosa no longo prazo. Métodos: estudo retrospectivo que incluiu todos os pacientes com mais de 60 anos submetidos ao Bypass gástrico em Y de Roux (BGYR) em nosso centro e que mantiveram seguimento superior a 1 ano. Foram estudadas variáveis clínicas e laboratoriais para avaliação da remissão da obesidade e suas comorbidades, além de variáveis diretamente relacionados ao procedimento cirúrgico em si, incluindo complicações precoces e tardias. Resultados: foram estudados 56 pacientes, a maioria do sexo feminino (76,8%), com idade média de 64,02 ± 3,34. Foi observada uma taxa de complicações de 37,5%, com 10,7% requerendo internamento hospitalar e cirurgia de urgência. A média geral da perda do excesso de peso (%PEP) foi de 74,22% ± 26,76. As taxas de remissão de hipertensão e diabetes mellitus foram de 26,08% e 54,54%, respectivamente. Houve variação significativa no IMC (12,25 ± 5,42, p<0,001), colesterol total (31,37 ± 38,89 p<0,001), colesterol LDL (23,45 ± 34,9, p=0,002), colesterol HDL (5,14 ± 11,13, p=0,024), triglicerídeos (48,85 ± 56,15 p<0,001), HbA1C (1,81 ± 1,97, p<0,001) e PCR (1,43 ± 1,96, p<0,001). Conclusão: a cirurgia bariátrica se mostrou eficaz na perda de peso e na remissão de comorbidades na população de idosos com obesidade no longo prazo..

ABSTRACT Introduction: to evaluate the long-term impact of bariatric surgery in the elderly population. Methods: a retrospective study including all patients older than 60 years who underwent Roux-en-Y gastric bypass (RYGB) at our center and maintained a follow-up longer than 1 year. Clinical and laboratory variables were studied to assess remission of obesity and its comorbidities, as well as variables directly related to the surgical procedure itself, including early and late complications. Results: fifty-six patients were studied, mostly female (76,8%), with a mean age of 64.02 ± 3.34. A rate of complications of 37,5% was observed, with 10,7% requiring hospital admission and emergency surgery. The mean excess weight loss (%EWL) was 74.22% ± 26.76. The remission rates of hypertension and diabetes mellitus were 26.08% and 54.54%, respectively. There was significant difference in BMI reduction (12.25 ± 5.42, p<0.001), total cholesterol (31.37 ± 38.89 p<0,001), LDL cholesterol (23.45 ± 34.9, p=0.002), HDL cholesterol (5.14 ± 11.13, p=0,024), triglycerides (48.85 ± 56.15 p<0.001), HbA1C (1,81 ± 1,97, p<0,001) e PCR (1.43 ± 1.96, p<0.001). Conclusion: bariatric surgery was effective in weight loss and remission of comorbidities in the elderly obese population within the long term.

https://doi.org/10.1590/0100-6991e-20223299-en

Trypanocidal Activity and Increased Solubility of Benznidazole Incorporated in PEG 4000 and Its Derivatives
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Sousa, Lucas R. D.

; Azevedo, Maria Luíza S.

; Rocha, Dayana F.

; Andrade, Ângela L.

; Amparo, Tatiane R.

; Santos, Orlando D. H. dos

; Seibert, Janaína B.

; Pereira, Luciano R.

; Vieira, Paula M. A.

; Carneiro, Cláudia M.

; Barboza, Ana Paula M.

; Neves, Bernardo R. A.

; Sales Jr., Policarpo A.

; Murta, Silvane M. F.

; Novack, Kátia M.

; Santos, Viviane M. R. dos

Journal of the Brazilian Chemical Society

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jun 2021, Volume 32 N. 6 Pages 1162 - 1172

Abstract: En | Text: En | PDF: En

Selecting a polymer depends on its characteristics, the properties of the drug and of the remaining ingredients in the formulation. The drug, when incorporated into a polymeric matrix, can show several advantages when compared with its conventional form. In this context, this work describes the preparation and characterization of polyethylene glycol (PEG 4000) and its derivative particles loaded with benznidazole, as well as evaluates their trypanocidal activity. In this work, reactions to modify the PEG 4000 polymer and the subsequent incorporation of the benznidazole were made. The nuclear magnetic resonance (NMR) analysis confirmed the efficiency in modifying the PEG chains. The morphology of polymeric films was observed by atomic force microscopy (AFM) and showed considerable changes on the film organization. The acetylation of PEG favored the stability of the system and an increase in the zeta potential from ?14.83 to ?25.54 mV was observed. Although encapsulation efficiency values between 30.14 and 39.48% were found, the enhanced benznidazole dissolution profile by microparticles enables the use of lower drug concentrations. This fact can be proven by the increased trypanocidal effect of benznidazole when encapsulated in BP3 microparticles. Finally, the high selectivity of the formulations for trypanocidal action guarantees their safety as an alternative for the treatment of the Chagas disease.

https://doi.org/10.21577/0103-5053.20210017 96 downloads

Caracterização Histológica das Lesões da Valva Mitral de Pacientes com Cardiopatia Reumática
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Gomes, Nayana F. A.

; Pascoal-Xavier, Marcelo A.

; Passos, Livia S. A.

; Paula, Thiago Mendonça Nunes

; Aguiar, João Marcelo de Souza

; Guarçoni, Felipe Vieira

; Nassif, Maria Cecília Landim

; Gelape, Claudio Leo

; Braulio, Renato

; Costa, Paulo Henrique N.

; Passaglia, Luiz Guilherme

; Martins, Raquel Braga

; Dutra, Walderez O.

; Nunes, Maria Carmo P.

Arquivos Brasileiros de Cardiologia

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mar 2021, Volume 116 N. 3 Pages 404 - 412

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamentos: Os mecanismos subjacentes pelos quais a doença cardíaca reumática (DCR) levam à disfunção valvar grave não são totalmente compreendidos. Objetivo: O presente estudo avaliou as alterações histopatológicas nas valvas mitrais (VM) buscando uma associação entre o padrão de disfunção valvar predominante e os achados histopatológicos. Métodos: Em 40 pacientes submetidos à troca da VM devido a DCR e em 20 controles submetidos a transplante cardíaco, foram analisados os aspectos histológicos da VM excisada. Dados clínicos e ecocardiográficos também foram coletados. As análises histológicas foram realizadas usando coloração com hematoxilina-eosina. Determinou-se inflamação, fibrose, neoangiogênese, calcificação e metaplasia adiposa. Valores de p<0,05 foram considerados estatisticamente significativos. Resultados: A idade média dos pacientes com DCR foi de 53±13 anos, sendo 36 (90%) do sexo feminino, enquanto a idade média dos controles foi de 50±12 anos, semelhante aos casos, sendo a maioria do sexo masculino (70%). O endocárdio valvar reumático apresentou espessura maior que os controles (1,3±0,5 mm versus 0,90±0,4 mm, p=0,003, respectivamente), e infiltrado inflamatório mais intenso no endocárdio (78% versus 36%; p=0,004), com predominância de células mononucleares. Ocorreu fibrose moderada a acentuada mais frequentemente em válvulas reumáticas do que em válvulas controle (100% vs. 29%; p<0,001). Ocorreu calcificação em 35% das valvas reumáticas, principalmente entre as valvas estenóticas, associada à área valvar mitral (p=0,003). Conclusões: Apesar do intenso grau de fibrose, o processo inflamatório permanece ativo na valva mitral reumática, mesmo em doença tardia com disfunção valvar. A calcificação predominou em valvas estenóticas e em pacientes com disfunção ventricular direita.

Abstract Background: The underlying mechanisms by which rheumatic heart disease (RHD) lead to severe valve dysfunction are not completely understood. Objective: The present study evaluated the histopathological changes in mitral valves (MV) seeking an association between the pattern of predominant valvular dysfunction and histopathological findings. Methods: In 40 patients who underwent MV replacement due to RHD, and in 20 controls that underwent heart transplant, histological aspects of the excised MV were analyzed. Clinical and echocardiographic data were also collected. Histological analyses were performed using hematoxylin-eosin staining. Inflammation, fibrosis, neoangiogenesis, calcification and adipose metaplasia were determined. A p value<0.05 was considered to be statistically significant. Results: The mean age of RHD patients was 53±13 years, 36 (90%) were female, whereas the mean age of controls was 50±12 years, similar to the cases, with the majority of males (70%). The rheumatic valve endocardium presented greater thickness than the controls (1.3±0.5 mm versus 0.90±0.4 mm, p=0.003, respectively), and a more intense inflammatory infiltrate in the endocardium (78% versus 36%; p=0.004), with predominance of mononuclear cells. Moderate to marked fibrosis occurred more frequently in rheumatic valves than in control valves (100% vs. 29%; p<0.001). Calcification occurred in 35% of rheumatic valves, especially among stenotic valves, which was associated with the mitral valve area (p=0.003). Conclusions: Despite intense degree of fibrosis, the inflammatory process remains active in the rheumatic mitral valve, even at late disease with valve dysfunction. Calcification predominated in stenotic valves and in patients with right ventricular dysfunction.

https://doi.org/10.36660/abc.20200154 542 downloads

FATTY ACIDS ANALYSIS AND CHEMOTAXONOMIC CONSIDERATIONS OF MALVOIDEAE (MALVACEAE) SPECIES
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Fernandes, Diégina A.

; Chaves, Otemberg S.

; Teles, Yanna C. F.

; Agra, Maria de F.

; Vieira, Maria A. R.

; Silva, Paulo S. S. da

; Marques, Marcia O. M.

; Souza, Maria de Fátima Vanderlei de

Química Nova

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feb 2021, Volume 44 N. 2 Pages 137 - 141

Abstract: En | Text: En | PDF: En

Previous researches showed that fatty acids analysis might be a useful tool to support the taxonomic investigation. In this approach the fatty acids content of ten Malvoideae species was analyzed and its chemotaxonomic significance has been investigated. The aerial parts of the species were collected in the Northeast of Brazil and their fatty acid methyl esters were analyzed by gas chromatography with flame ionization detector. The chemometric analysis consisted of principal component analysis (PCA) and hierarchical clustering analysis (HCA) with the euclidean distance between the samples given by the Ward.D2 algorithm. This is the first report of fatty acids from Wissadula peripocifolia, Herissantia crispa, Bakeridesia pickelii, Sidastrum micranthum, Pavonia cancellata and Pavonia malacophylla. The results showed the predominance of palmitic (C16:0), oleic (C18:1) and linoleic (C18:2) acids in the studied species. By the PCA and HCA analysis, the fatty acid composition was able to distinguish the species Herissantia crispa and Pavonia malacophylla. Our findings showed a chemotaxonomic proximity among species from different genera reflecting the taxonomic and phylogenetic closeness previously demonstrated by molecular investigations on Malvoidae species. Furthermore, our results demonstrated that the fatty acid analysis may be an interesting tool to support the taxonomic investigations on Malvoideae species.

https://doi.org/10.21577/0100-4042.20170668 125 downloads

Synthesis of Antioxidant Additive from Safflower Seed Oil
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Vieira, Maríthiza G.

; Batista, Lilian R.

; Muniz, Aline S.

; Lichston, Juliana E.

; Oliveira, Angelo R. S.

; César-Oliveira, Maria A. F.

; Antoniosi Filho, Nelson R.

Journal of the Brazilian Chemical Society

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jan 2021, Volume 32 N. 1 Pages 40 - 46

Abstract: En | Text: En | PDF: En

Several published studies have evaluated the problems associated with the utilization of biodiesel obtained from safflower (Carthamus tinctorius L.) oil due to the low oxidative stability, caused by the high content of unsaturated fatty acids. Thus, this study aimed at the extraction of safflower seed oil and its use as an unsaturation source to obtain a synthetic antioxidant. The synthesis of this phenolic additive was done by modifying its structure through the addition of hydroquinone to the unsaturation of the oil, by electrophilic substitution. It was investigated and confirmed that this reaction is promising for obtaining phenolic products, with high yields (83.5%). The product obtained in this research was evaluated as an antioxidant in commercial biodiesel by the Rancimat method, using 5000 ppm of the synthesized additive the induction period increased from 8 to 17 h (2.12 times). Therefore, this paper brought a positive response to the improvement of biodiesel oxidation stability that creates a possibility to increase the use and expansion of this fuel in the market, as utilization of the safflower seed as raw material for additives, bringing a new market for these seeds.

https://doi.org/10.21577/0103-5053.20200151 294 downloads

10.

MINIATURIZED LIQUID-LIQUID EXTRACTION WITH LOW-TEMPERATURE PARTITIONING TECHNIQUE (LLE/LTP) FOR PESTICIDE ANALYSIS IN A BIOLOGICAL MATRIX BY GAS CHROMATOGRAPHY
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Silva, Thaís Lindenberg R.

; Queiroz, Maria Eliana L. R. de

; Neves, Antônio A.

; Vieira, Patrícia Aparecida F.

; Oliveira, André F. de

; Oliveira, Maria Goreti de A.

Química Nova

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2021, Volume 44 N. 7 Pages 804 - 808

Abstract: En | Text: En | PDF: En

The liquid-liquid extraction with low-temperature partitioning technique (LLE/LTP) was miniaturized to determine the pesticides chlorpyrifos, bifenthrin, λ-cyhalothrin, and deltamethrin in a biological matrix, by gas chromatography. The method was proposed for fetal-bovine serum samples (500 μL), by using a full factorial design (23) with one center point. The evaluated factors included the volume of water added to the sample (1000 μL), volume of extraction solvent (500 μL) and stirring time (60 s) – a cleanup step was not necessary. The method was validated for the main figures of merit. The results indicated that the LLE/LTP/GC/ECD miniaturized method was efficient in extracting pesticides from blood-serum samples (75 to 115%). It showed both selectivity and sensitiveness, with limits of quantification (LOQ) ranging from 8 at 17 μg L-1;. Once validated, the method was applied to blood-serum samples of rural workers from a city in the Brazilian state of Minas Gerais. In that case, the presence of chlorpyrifos was detected in two of the samples.

https://doi.org/10.21577/0100-4042.20170738 77 downloads

11.

BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION
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Lopes, Karen P. S.

; Cavalcante, Igor M.

; Silva, Raquel F. da

; Brito, Débora H. A. de

; Fechine, Lillian M. U. D.

; Moreira, Denise R.

; Vieira, Ícaro G. P.

; Azul, Francisco Vinícius Clemente S.

; Leal, Luzia K. A. M.

; Ribeiro, Maria E. N. P.

; Ricardo, Nágila M. P. S.

Química Nova

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sep 2020, Volume 43 N. 8 Pages 1011 - 1016

Abstract: En | Text: En | PDF: En

Micelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of cytotoxicity (MTT assay) revealed that the copolymers F127 and E45S8 had considerable biocompatibility and did not affect the metabolism of human neutrophils. The binary systems were also evaluated by critical micellar concentration (CMC) and thermoresponsive behavior. The CMC values were intermediate to those of the isolated copolymers. The systems maintained the thermoresponsive properties present in F127 making the systems interesting for subcutaneous administration. The systems presented small size, an average range in size from 17 to 38 nm, and the samples prepared with higher hydrophobic proportion presented more uniform sizes. Results suggest stability and the increasing of the nanosystems circulation time. The F/ES 30/70 system has polydispersity smaller than 0.1 and showed an increase of 129 times for quercetin solubility. Thus, it is possible to consider F127/E45S8 micelles as potential nanosystems for poorly soluble drug delivery.

https://doi.org/10.21577/0100-4042.20170570 361 downloads

12.

Regenerated Cellulose Membrane from Peanut Shell for Biodiesel Purification
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Reis, Ana Maria S.

; Vieira, Andressa T.

; Santos, Allyson L. R.

; Ferreira, Marcos V.

; Batista, Antônio C. F.

; Assunção, Rosana M. N.

; Rodrigues Filho, Guimes

; Ribeiro, Elaine A. M.

; Faria, Anizio M.

Journal of the Brazilian Chemical Society

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may 2020, Volume 31 N. 5 Pages 1011 - 1020

Abstract: En | Text: En | PDF: En

Biodiesel purification by water washing has been proved to be an unattractive process from an economic and environmental point of view. In this work, we propose the use of regenerated cellulose membranes from peanut shell as an alternative in the biodiesel purification. The preparation of the membranes was optimized from a central composite design, resulting in dense and non-porous membranes. However, in contact with biodiesel, the membranes undergo expansion due to the retention of methanol, water, and glycerol molecules, allowing the permeation of fatty acid methyl esters. The filtered biodiesel presents quality parameters, such as total ester content of 98.3 ± 1.4% and free glycerol content < 0.02%, in agreement with the main regulatory agencies. The regenerated cellulose membranes from peanut shell are easily prepared, with high repeatability (relative standard deviation (RSD) < 1.8%) and are presented as an economical and environmental solution for the biodiesel purification.

https://doi.org/10.21577/0103-5053.20190267 277 downloads

13.

Rheumatic heart disease in the modern era: recent developments and current challenges
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Leal, Matheus Tozatto Baptista Coelho

; Passos, Livia Silva Araújo

; Guarçoni, Felipe Vieira

; Aguiar, João Marcelo de Souza

; Silva, Rafael Benjamim Rosa da

; Paula, Thiago Mendonça Nunes de

; Santos, Rafael Figueiredo dos

; Nassif, Maria Cecília Landim

; Gomes, Nayana F. A.

; Tan, Timothy C.

; Nunes, Maria Carmo Pereira

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180041

Abstract: En | Text: En | PDF: En

Abstract Rheumatic heart disease (RHD) remains a major cause of preventable death and disability in children and young adults. Despite significant advances in medical technology and increased understanding of disease mechanisms, RHD continues to be a serious public health problem throughout the world, especially in low- and middle-income countries. Echocardiographic screening has played a key role in improving the accuracy of diagnosing RHD and has highlighted the disease burden. Most affected patients present with severe valve disease and limited access to life-saving cardiac surgery or percutaneous valve intervention, contributing to increased mortality and other complications. Although understanding of disease pathogenesis has advanced in recent years, key questions remain to be addressed. Preventing or providing early treatment for streptococcal infections is the most important step in reducing the burden of this disease.

https://doi.org/10.1590/0037-8682-0041-2019 7841 downloads

14.

Brazilian legislation on genetic heritage harms Biodiversity Convention goals and threatens basic biology research and education
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ALVES, RUY JOSÉ V.

; WEKSLER, MARCELO

; OLIVEIRA, JOÃO A.

; BUCKUP, PAULO A.

; POMBAL JR., JOSÉ P.

; SANTANA, HÉLCIO R.G.

; PERACCHI, ADRIANO LÚCIO

; KELLNER, ALEXANDER W.A.

; ALEIXO, ALEXANDRE

; LANGGUTH, ALFREDO

; ALMEIDA, ALZIRA MARIA P. DE

; ALBERNAZ, ANA LUISA

; RIBAS, CAMILA C.

; ZILBERBERG, CARLA

; GRELLE, CARLOS EDUARDO V.

; ROCHA, CARLOS F.D.

; LAMAS, CARLOS JOSÉ E.

; HADDAD, CÉLIO F.B.

; BONVICINO, CIBELE R.

; PRADO, CYNTHIA P.A.

; LIMA, DANIELA O. DE

; ROSSA-FERES, DENISE C.

; SANTOS, FABRÍCIO R. DOS

; SALIMENA, FÁTIMA REGINA G.

; PERINI, FERNANDO A.

; BOCKMANN, FLÁVIO A.

; FRANCO, FRANCISCO LUÍS

; GIUDICE, GISELE M.L. DEL

; COLLI, GUARINO R.

; VIEIRA, IMA CÉLIA G.

; MARINHO-FILHO, JADER

; WERNECK, JANE M.C.F.

; SANTOS, JORGE A.D. DOS

; NASCIMENTO, JORGE LUIZ DO

; NESSIMIAN, JORGE LUIZ

; CORDEIRO, JOSÉ LUIS P.

; CLARO, KLEBER DEL

; SALLES, LEANDRO O.

; CASATTI, LILIAN

; PY-DANIEL, LUCIA HELENA R.

; SILVEIRA, LUÍS FÁBIO

; TOLEDO, LUÍS FELIPE

; OLIVEIRA, LUIZ F. DE

; MALABARBA, LUIZ ROBERTO

; SILVA, MARCELO D. DA

; COURI, MÁRCIA S.

; MARTINS, MÁRCIO

; TAVARES, MARCOS D.S.

; SOBRAL, MARCOS EDUARDO G.

; VIEIRA, MARCUS VINÍCIUS

; OLIVEIRA, MARIA DE LOURDES A.

; PINNA, MÁRIO DE

; HOPKINS, MICHAEL J.G.

; SOLÉ, MIRCO

; MENEZES, NAÉRCIO A.

; PASSOS, PAULO

; D’ANDREA, PAULO SERGIO

; PINTO, PEDRO C.E.A.

; VIANA, PEDRO L.

; TOLEDO, PETER M.

; REIS, ROBERTO E.

; VILELA, ROBERTO

; BASTOS, ROGÉRIO P.

; COLLEVATTI, ROSANE G.

; CERQUEIRA, RUI

; CASTROVIEJO-FISHER, SANTIAGO

; CARAMASCHI, ULISSES

Anais da Academia Brasileira de Ciências

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apr 2018, Volume 90 N. 2 Pages 1279 - 1284

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0001-3765201820180460 7311 downloads

15.

ESTUDO ATRAVÉS DE RMN DE 13C NO ESTADO SÓLIDO SOBRE A SÍNTESE DE OXIDO DE GRAFITE UTILIZANDO DIFERENTES PRECURSORES GRAFÍTICOS
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Vieira, Mariana A.

; Frasson, Carolina Maria R.

; Costa, Tainara Luiza G.

; Cipriano, Daniel F.

; Schettino Jr., Miguel A.

; Cunha, Alfredo G.

; Freitas, Jair C. C.

Química Nova

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oct 2017, Volume 40 N. 10 Pages 1164 - 1171

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The influence of the structural and microstructural characteristics of graphitic precursors on the production of graphite oxide (GO) is investigated in the present work. Six different graphitic precursors were used to produce GO following a modified Hummers method, namely: natural graphite, commercial lubricant graphite, milled graphite, graphite flakes, high-purity graphite and graphite recycled from Li-ion batteries. The products were characterized by X-ray diffraction (XRD), thermogravimetry, solid-state 13C nuclear magnetic resonance (NMR) and scanning electron microscopy (SEM). 13C NMR spectra revealed the presence of epoxy, hydroxyl, carbonyl and lactol groups in the synthesized GOs. However, the oxidation degree of each product was found to be dependent on the average crystallite size (Lc) and particle size of the graphitic precursors, with the best GO samples being produced from the milled graphite and the graphite recycled from ion-Li batteries. These results were rationalized in terms of the structural and microstructural differences among the graphitic precursors, as revealed by the XRD patterns and SEM images, evidencing the importance of the correct choice of the precursor aiming the achievement of a well-developed structure for the GO product.

https://doi.org/10.21577/0100-4042.20170129 2022 downloads

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