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Abstract Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.

https://doi.org/10.1590/0001-3765202220211590

Posicionamento Brasileiro sobre o Uso da Multimodalidade de Imagens na Cardio-Oncologia – 2021
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Melo, Marcelo Dantas Tavares de

; Paiva, Marcelo Goulart

; Santos, Maria Verônica Câmara

; Rochitte, Carlos Eduardo

; Moreira, Valéria de Melo

; Saleh, Mohamed Hassan

; Brandão, Simone Cristina Soares

; Gallafrio, Claudia Cosentino

; Goldwasser, Daniel

; Gripp, Eliza de Almeida

; Piveta, Rafael Bonafim

; Silva, Tonnison Oliveira

; Santo, Thais Harada Campos Espirito

; Ferreira, Waldinai Pereira

; Salemi, Vera Maria Cury

; Cauduro, Sanderson A.

; Barberato, Silvio Henrique

; Lopes, Heloísa M. Christovam

; Pena, José Luiz Barros

; Rached, Heron Rhydan Saad

; Miglioranza, Marcelo Haertel

; Pinheiro, Aurélio Carvalho

; Vrandecic, Bárbara Athayde Linhares Martins

; Cruz, Cecilia Beatriz Bittencourt Viana

; Nomura, César Higa

; Cerbino, Fernanda Mello Erthal

; Costa, Isabela Bispo Santos da Silva

; Coelho Filho, Otavio Rizzi

; Carneiro, Adriano Camargo de Castro

; Burgos, Ursula Maria Moreira Costa

; Fernandes, Juliano Lara

; Uellendahl, Marly

; Calado, Eveline Barros

; Senra, Tiago

; Assunção, Bruna Leal

; Freire, Claudia Maria Vilas

; Martins, Cristiane Nunes

; Sawamura, Karen Saori Shiraishi

; Brito, Márcio Miranda

; Jardim, Maria Fernanda Silva

; Bernardes, Renata Junqueira Moll

; Diógenes, Tereza Cristina

; Vieira, Lucas de Oliveira

; Mesquita, Claudio Tinoco

; Lopes, Rafael Willain

; Segundo Neto, Elry Medeiros Vieira

; Rigo, Letícia

; Marin, Valeska Leite Siqueira

; Santos, Marcelo José

; Grossman, Gabriel Blacher

; Quagliato, Priscila Cestari

; Alcantara, Monica Luiza de

; Teodoro, José Aldo Ribeiro

; Albricker, Ana Cristina Lopes

; Barros, Fanilda Souto

; Amaral, Salomon Israel do

; Porto, Carmen Lúcia Lascasas

; Barros, Marcio Vinícius Lins

; Santos, Simone Nascimento dos

; Cantisano, Armando Luís

; Petisco, Ana Cláudia Gomes Pereira

; Barbosa, José Eduardo Martins

; Veloso, Orlando Carlos Glória

; Spina, Salvador

; Pignatelli, Ricardo

; Hajjar, Ludhmilla Abrahão

; Kalil Filho, Roberto

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Vieira, Marcelo Luiz Campos

; Almeida, André Luiz Cerqueira

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 845 - 909

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200266 103 downloads

Body self-image disturbances in women with prolactinoma
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Pereira, Helen S.

; Naliato, Erika C.

; Moraes, Aline B.

; Gadelha, Monica R.

; Vieira Neto, Leonardo

; Almeida, Renan M.

; Nardi, Antonio E.

; Violante, Alice H.

Brazilian Journal of Psychiatry

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feb 2020, Volume 42 N. 1 Pages 33 - 39

Abstract: En | Text: En | PDF: En

Objective: To evaluate body dissatisfaction and distorted body self-image in women with prolactinoma. Methods: Body dissatisfaction and distorted body self-image were evaluated in 80 women with prolactinoma. All patients were in menacme, 34% had normal body mass index (BMI), and 66% were overweight. Most patients (56.2%) had normal prolactin (PRL) levels and no hyperprolactinemia symptoms (52.5%). The Body Shape Questionnaire (BSQ) was used to assess the patients’ dissatisfaction with and concern about their physical form, and the Stunkard Figure Rating Scale (FRS) was used to assess body dissatisfaction and distorted body self-image. The patients were divided according to PRL level (normal vs. elevated) and the presence or absence of prolactinoma symptoms. Results: The normal and elevated PRL groups had similar incidences of body dissatisfaction and distorted body self-image. However, symptomatic patients reported a higher incidence of dissatisfaction than asymptomatic patients. Distorted body self-image was less common among symptomatic patients. Conclusion: Symptomatic patients showed higher body dissatisfaction, but lower body self-image distortion. The presence of symptoms may have been responsible for increased body awareness. The perception of body shape could have triggered feelings of dissatisfaction compared to an ideal lean body. Therefore, a distorted body self-image might not necessarily result in body dissatisfaction in women with prolactinomas.

https://doi.org/10.1590/1516-4446-2018-0325 680 downloads

High Throughput Mass Spectrometry Platform for Prospecting High Value Chemicals from Bioconversion of Glycerin
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Amazonas, Diana R.

; Souto, Augusto L.

; Vieira, Flávia S.

; Carneiro, Andréia A. J.

; Vianna, Rebeca B.

; Mendes, Thaís D.

; Lima, Karen S.

; Ribeiro, José A. A.

; Damaso, Mônica C. T.

; Rodrigues, Clenilson M.

; Abdelnur, Patrícia V.

Journal of the Brazilian Chemical Society

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dec 2019, Volume 30 N. 12 Pages 2712 - 2720

Abstract: En | Text: En | PDF: En

The use of bioprocess to convert low valued biomass or agroindustrial byproducts into high-value chemicals is an emerging area. However, laboratories usually use outdated analytical techniques to identify bioproducts, losing valuable information, such as the identification of unexpected compounds. In this work, we presented a successful systematic and modern analytical approach based on direct infusion mass spectrometry (DIMS) for an automated high-throughput screening of untargeted compounds from glycerin bioconversion process. We describe advantages of DIMS and its combined application with chemometrics towards an untargeted metabolomics approach to analyze several samples in a short time (11 samples per h). Three batches with 34 samples from the bioconversion of glycerin using several filamentous fungi strains were analyzed. Batch 347 was selected as promising, since high value chemicals, such as amide, phenolic and acid compounds, were identified. The platform presented was fast, robust, and versatile, then it could be applied to different bioprocesses.

https://doi.org/10.21577/0103-5053.20190210 354 downloads

Characteristics associated with activity restriction induced by fear of falling in community-dwelling elderly
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Dias, Rosângela C.

; Freire, Maria T. F.

; Santos, Érika G. S.

; Vieira, Renata A.

; Dias, João M. D.

; Perracini, Mônica R.

Brazilian Journal of Physical Therapy

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oct 2011, Volume 15 N. 5 Pages 406 - 413

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Determinar os fatores sociodemograficos, clinicos, funcionais e psicologicos associados a restricao de atividades por medo de cair em idosos comunitarios e identificar quais variaveis melhor discriminam os grupos em relacao a restricao de atividades por medo de cair. MÉTODOS: Cento e treze idosos comunitarios (74,5�±7 anos) participaram do estudo. Foram avaliados: restricao de atividades por medo de cair, historia de quedas, autoeficacia relacionada as quedas, fenotipo de fragilidade, aspectos sociodemograficos e clinicos, capacidade funcional, depressao e autopercepcao de saude. Estatisticas descritivas, teste qui-quadrado, ANOVA e o teste Kruskal-Wallis foram utilizados para analisar as relacoes entre a restricao de atividades por medo de cair e as outras variaveis. O metodo Chi-Square Automatic Interaction Detection (CHAID) foi utilizado para verificar quais variaveis melhor discriminavam os grupos em relacao a restricao de atividades (α=0,05). RESULTADOS: Idosos que relataram restricao de atividades por medo de cair apresentaram maior autorrelato de depressao (p=0,038), menor autoeficacia em relacao as quedas (p<0,001), menor velocidade de marcha (p=0,043) e nivel de independencia para realizacao de atividades instrumentais de vida diaria (p=0,017), maior numero de doencas (p=0,048), pior autopercepcao de saude (p=0,040) e maior presenca de sintomatologia depressiva (p=0,023). As variaveis que melhor discriminaram os grupos foram depressao (p=0,004), exaustao (fenotipo de fragilidade) (p=0,010) e participacao em atividades sociais (p=0,016). CONCLUSÃO: A restricao de atividades por medo de cair pode ter efeitos negativos na capacidade funcional e nos aspectos psicologicos de idosos comunitarios. Fatores psicossociais parecem discriminar melhor os idosos que apresentam restricao de atividades por medo de cair.

OBJECTIVES: The aim of this study was to determine the social-demographic, clinical, functional and psychological factors associated to activity restriction due to fear of falling in community-dwelling elderly and identify which variables best discriminate groups of elderly with different levels of activity restriction and fear of falling. METHODS: One hundred and thirteen community-dwelling elderly (74.5±7 years old) participated in the study. Activity restriction induced by fear of falling, previous falls, fall related self-efficacy, frailty phenotype, functional capacity, depressive symptoms, health self-perception, socio-demographic and clinical factors were assessed. Descriptive statistics, chi-square, ANOVA and Kruskal Wallis tests were used to analyze the associations between activity restriction due to fear of falling and all other variables. Path analysis (CHAID) method was used to verify which variables better discriminated groups in relation to activity restriction (α=0.05). RESULTS: The participants who reported fear of falling and activity restriction demonstrated higher depression (p=0.038), lower fall related self-efficacy (p<0.001), lower gait velocity (p=0.043) and independence level for instrumental daily living activities (p=0.017), higher number of diseases (p=0.048), worse health self-perception (p=0.040) and more depressive symptom (p=0.023). The best variables to discriminate groups were depression (p=0.004), exhaustion (frailty phenotype) (p=0.010) and social participation activities (p=0.016). CONCLUSION: Activity restriction due to fear of falling may have negative effects on functional capacity and psychological aspects in community-dwelling elderly. Psychosocial factors seem to better discriminate the elderly who avoid activities due to fear of falling.

9541 downloads

Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening
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Pinho, Leandro Kasuki Jomori de

; Vieira Neto, Leonardo

; Wildemberg, Luiz Eduardo Armondi

; Moraes, Aline Barbosa

; Takiya, Christina M.

; Frohman, Lawrence A.

; Korbonits, Márta

; Gadelha, Mônica R.

Arquivos Brasileiros de Endocrinologia & Metabologia

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nov 2010, Volume 54 N. 8 Pages 698 - 704

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Apresentamos dados clínicos e moleculares de quatro famílias com adenoma hipofisário familiar isolado (FIPA) enfatizando as diferenças na presença ou não de mutação do AIP e a importância da triagem genética. A Família 1 é composta por cinco pacientes portadores de somatotropinomas com mutação germinativa E24X no AIP. Um dos pacientes foi diagnosticado por meio de rastreio ativo, com cura cirúrgica. As Famílias 2 e 3 apresentam em sua composição dois pacientes com adenomas hipofisários não funcionantes. A Família 4 compreende dois pacientes, um com prolactinoma e outro com somatotropinoma. Não foi encontrada mutação no AIP nessas famílias. Na Família 1, não houve resposta ao octreotide, enquanto o paciente acromegálico da Família 4 foi controlado com a medicação. Em conclusão, a FIPA é uma condição heterogênea que pode estar associada à mutação do AIP e o rastreio genético/clínico é recomendado nas famílias com dois ou mais membros portadores de adenoma hipofisário. Isso permite um diagnóstico precoce, com melhor prognóstico.

We present four FIPA kindred discussing clinical and molecular data and emphasizing the differences regarding AIP status, as well as the importance of genetic screening. Family 1 consists of five patients harboring somatotropinomas with germline E24X mutation in AIP. In one of the patients, acromegaly was diagnosed through active screening, being cured by surgery. Families 2 and 3 are composed of two patients with non-functioning pituitary adenomas. Family 4 comprises patients harboring a prolactinoma and a somatotropinoma. No mutations in AIP were found in these families. No patient in Family 1 was controlled with octreotide treatment, while the acromegalic patient in Family 4 was controlled with octreotide LAR. In conclusion, FIPA is a heterogeneous condition, which may be associated with AIP mutation. Genomic and clinical screening is recommended in families with two or more members harboring pituitary adenomas, allowing early diagnosis and better outcome.

3265 downloads

Efeito da adição de clonidina subaracnóidea à bupivacaína hiperbárica e sufentanil para analgesia de parto
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Cardoso, Mônica Maria Siaulys Capel

; Papa, Fabio V.

; Vieira, Roberta F.

; Kondo, Mário M.

; Torres, Marcelo Luis Abramides

Revista Brasileira de Anestesiologia

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apr 2006, Volume 56 N. 2 Pages 119 - 125

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

JUSTIFICATIVA E OBJETIVOS: A adição de clonidina subaracnóidea (um alfa-agonista), prolonga a ação analgésica da combinação do sufentanil e da bupivacaína isobárica em analgesia combinada para o trabalho de parto. O objetivo desse estudo foi comparar a qualidade e a duração de analgesia e a incidência de efeitos colaterais após a adição de clonidina subaracnóidea à bupivacaína hiperbárica e sufentanil em anestesia combinada raqui-peridural para o trabalho de parto. MÉTODO: Foram estudadas 26 gestantes de termo, estado físico ASA I, em trabalho de parto, que receberam aleatoriamente no espaço subaracnóideo: clonidina, sufentanil e bupivacaína (n = 13), denominado Grupo Clon/Sufenta/Bupi, 2,5 mg de bupivacaína hiperbárica a 0,5% associada a 2,5 µg de sufentanil e 30 µg de clonidina; sufentanil e bupivacaína (n = 13), denominado Grupo Sufenta/Bupi, 2,5 mg de bupivacaína hiperbárica a 0,5% associada a 2,5 µg de sufentanil. O estudo foi duplamente encoberto. A dor e os efeitos colaterais (náusea, vômito, prurido, hipotensão arterial e sedação) foram avaliados a cada cinco minutos nos primeiros 15 minutos e, a seguir, a cada 15 minutos até o nascimento. A dor foi avaliada com a escala analógica visual de 0-10 cm (VAS = 0, ausência de dor e 10, dor insuportável), e o estudo foi encerrado no momento em que foi necessária complementação analgésica peridural (dor > 3 cm) ou ao nascimento. A análise estatística foi realizada com os testes t de Student e Exato de Fisher, considerando como significativo p < 0,05. RESULTADOS: As médias de dor nos momentos - 0 min (8,9 ± 1,6/7,6 ± 2,1), 5 min (3,4 ± 2,3/2,3 ± 3,1), 10 min (1,5 ± 2,5/1,4 ± 2,2) e 15 min (0,26 ± 0,8/1,4 ± 2,2) nos grupos Clon/Sufenta/Bupi e Sufenta/Bupi foram semelhantes, respectivamente. Não se observaram diferenças em relação à duração da analgesia (58,8 ± 32 min / 55,4 ± 53 min), ocorrência de prurido (4/13 e 4/12 pacientes), náusea (1/13 e 1/12 pacientes), vômito (1/13 e 0/12 pacientes) e hipotensão arterial (2/13 e 1/12 pacientes) nos grupos Clon/Sufenta/Bupi e Sufenta/Bupi, respectivamente. Não se observou efeito sedativo da clonidina em nenhuma paciente. Uma paciente do grupo Sufenta/Bupi foi excluída do estudo por falha total do bloqueio após 15 minutos. CONCLUSÕES: Nas condições estudadas, a adição de clonidina em baixa dose (30 µg) e quando associada a soluções hiperbáricas não prolonga a duração da analgesia, não melhora a qualidade do bloqueio e não determina ocorrência de hipotensão arterial e/ou sedação.

BACKGROUND AND OBJECTIVES: Adding subarachnoid clonidine (an alpha -agonist) prolongs the analgesic effect of the combination of sufentanil and isobaric bupivacaine when combined during labor analgesia. The aim of this study was to compare the quality and duration of the analgesia as well as the incidence of side-effects after the addition of subarachnoid clonidine to hyperbaric bupivacaine and sufentanil in a combined spinal-epidural analgesia during labor. METHODS: Twenty-six patients, physical status ASA I in full-term pregnancy were studied. They randomly received the following in the subarachnoid space: clonidine, sufentanil and bupivacaine (n = 13) - referred to as the Clon/Sufenta/Bupi Group - wherein 2.5 mg of 0.5% hyperbaric bupivacaine was added to 2.5 µg of sufentanil and 30 µg of clonidine; sufentanil and bupivacaine (n = 13) - referred to as the Sufenta/Bupi Group - wherein 2.5 mg of 0.5% hyperbaric bupivacaine was added to 2.5 µg of sufentanil. This was a double-blind study. Evaluations of pain and side effects (nausea, vomiting, itching, low blood pressure and sedation) were conducted every five minutes for the first 15 minutes and after that, every 15 minutes up until the birth of the baby. Pain was evaluated using a visual analogic scale ranging from 0-10 cm (VAS 0 = absence of pain and 10 = unbearable pain). The study was over whenever complementary epidural anasthesia was found necessary (pain > 3 cm) or at the moment of birth. A Student t-test statistical analysis was performed and the results were significant (p < 0.05). RESULTS: The mean pain scores at the times measured were similar for the Clon/Sufenta/Bupi and Sufenta/Bupi Groups respectively: 0 min (8.9 ± 1.6/ 7.6 ± 2.1), 5 min (3.4 ± 2.3/ 2.3 ± 3.1), 10 min (1.5 ± 2.5/ 1.4 ± 2.2) and 15 min (0.26 ± 0.8/ 1.4 ± 2.2). No differences between the Clon/Sufenta/Bupi and Sufenta/Bupi Groups, respectively, were observed regarding: the duration of the analgesia (58.8 ± 32 min / 55.4 ± 53 min), itching (4/13 and 4/12 patients), nausea (1/13 and 1/12 patients), vomiting (1/13 and 0/12 patients) and low blood pressure (2/13 and 1/12 patients). The sedative effect of clonidine was not observed in any patient. One patient from the Sufenta/Bupi group was eliminated from the study because the anaesthesia failed to take effect after 15 minutues. CONCLUSIONS: Under the conditions observed in the study, adding a low dosage of clonidine when combined with a hyperbaric solution does not prolong the duration of the analgesia, does not improve the quality of the action and does not act as the determining factor for the occurence of low blood pressure or sedation.

JUSTIFICATIVA Y OBJETIVOS: La adición de clonidina subaracnoidea (un alfa -agonista), prolonga la acción analgésica de la combinación del sufentanil y de la bupivacaína isobárica en analgesia combinada para el trabajo de parto. El objetivo de este estudio fue comparar la calidad y la duración de la analgesia y la incidencia de los efectos colaterales después de la adición de clonidina subaracnoidea en la bupivacaína hiperbara y sufentanil en anestesia combinada raqui-peridural durante el trabajo de parto. MÉTODO: Fueron estudiadas 26 gestantes a término, estado físico ASA I, en trabajo de parto que recibieron, al acaso en el espacio subaracnoideo: clonidina, sufentanil y bupivacaína (n = 13), denominado Grupo Clon/Sufenta/Bupi, 2,5 mg de bupivacaína hiperbara al 0,5% asociada a 2,5 µg de sufentanil y 30 µg de clonidina; sufentanil y bupivacaína (n = 13), denominado Grupo Sufenta/Bupi, 2,5 mg de bupivacaína hiperbara al 0,5% asociada a 2,5 µg de sufentanil. El estudio fue doble ciego. El dolor y los efectos colaterales (náuseas, vómito, prurito, hipotensión arterial y sedación) fueron evaluados cada cinco minutos en los primeros 15 minutos y, a seguir, cada 15 minutos, hasta el nacimiento. El dolor fue evaluado con la escala analógica visual de 0-10 cm (VAS = 0, ausencia de dolor y 10, dolor insoportable) y el estudio fue encerrado en el momento en que se hizo necesaria la complementación analgésica peridural (dolor > 3 cm) o al alumbramiento. El análisis estadístico fue realizado con los testes t de Student y Exacto de Fisher, considerando como significativo p < 0,05. RESULTADOS: Los promedios de dolor en los momentos - 0 min (8,9 ± 1,6/7,6 ± 2,1) 5 min (3,4 ± 2,3/2,3 ± 3,1), 10 min (1,5 ± 2,5/1,4 ± 2,2) y 15 min (0,26 ± 0,8/1,4 ± 2,2) en los grupos Clon/Sufenta/Bupi y Sufenta/Bupi fueron respectivamente parecidos. No se observaron diferencias con relación a la duración de la analgesia (58,8 ± 32 min / 55,4 ± 53 min), ocurrencia de prurito (4/13 y 4/12 pacientes), náusea (1/13 y 1/12 pacientes), vómito (1/13 y 0/12 pacientes) e hipotensión arterial (2/13 y 1/12 pacientes) en los grupos Clon/Sufenta/Bupi y Sufenta/Bupi, respectivamente. No se observó ningún efecto sedante de la clonidina en ninguna paciente. Una paciente del grupo Sufenta/Bupi fue excluida del estudio por falla total del bloqueo después de 15 minutos. CONCLUSIONES: En las condiciones estudiadas, la adición de clonidina en dosis bajas (30 µg) y cuando asociada con soluciones hiperbaras no prolongo la duración de la analgesia, no mejoro la calidad del bloqueo ni determino la ocurrencia de hipotensión arterial y/o sedación.

3166 downloads

Terpenoids and Steroids from Trichilia Species
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Pupo, Mônica T.

; Adorno, M. Angela T.

; Vieira, Paulo C.

; Fernandes, João B.

; Silva, M. Fátima das G. F. da

; Pirani, José R.

Journal of the Brazilian Chemical Society

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jun 2002, Volume 13 N. 3 Pages 382 - 388

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O trabalho descreve o isolamento de três novos sesquiterpenóides do extrato metanólico dos galhos de Trichilia claussenii: 14-hidroxielemol, germacra-10(14)-en-9,11,15-triol e germacra-3,10(14)-dien-9,11-diol-4-carbaldeído. Também foram isolados os sesquiterpenos beta-eudesmol, criptomeridiol e o triterpeno 22,25-diidroxi-9beta,19-ciclolanost-23-en-3-ona. Do extrato diclorometânico das folhas de T. lepidota foram isolados mistura de hidrocarbonetos (C29H60, C31H64 e C33H68), mistura dos sesquiterpenos epóxido de cariofileno e epóxido de humuleno, espatulenol e os esteróides 24-metileno-12beta-hidroxicolesterol, 24-metil-12beta-hidroxicolest-4-en-3-ona, 3-palmitato de 24-metil-12beta-hidroxicolest-5-eno, mistura de 24-metilenocolesterol, campesterol, estigmasterol e beta-sitosterol, além de alfa-tocoferol e fitol. O extrato metanólico forneceu a N-metil-4-hidroxiprolina. As estruturas das substâncias isoladas foram estabelecidas com base em dados espectroscópicos.

The methanol extract of stems of Trichilia claussenii yielded three new sesquiterpenoids: 14-hydroxyelemol, germacra-10(14)-en-9,11,15-triol and germacra-3,10(14)-dien-9,11-diol-4-carbaldehyde. Two known sesquiterpenoids beta-eudesmol, cryptomeridiol and the triterpenoid 22,25-dihydroxy-9beta,19-cyclolanost-23-en-3-one were also isolated. The dichloromethane extract from the leaves of T. lepidota afforded a mixture of hydrocarbons (C29H60, C31H64 and C33H68), a mixture of the sesquiterpenes caryophyllene and humulene epoxides, spathulenol, and a series of sterols: 24-methylene-12b-hydroxycholesterol, 24-methyl-12beta-hydroxycholest-4-en-3-one, 24-methylene-12beta-hydroxycholest-5-ene-3-palmitate; a mixture of 24-methylenecholesterol, campesterol, stigmasterol and beta-sitosterol; besides alpha-tocoferol and phytol. From the methanol extract it was isolated N-methyl-4-hydroxyproline. The structures of the isolated compounds were determined on the basis of spectroscopic analysis.

3940 downloads

10.

A obesidade estaria relacionada ao aumento do volume das adrenais?
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Matos, Amélio F.G.

; Vieira, Andréa R.

; Coutinho, Walmir

; Madeira, Denise

; Carraro, Lúcia M.

; Rodrigues, Rosa

; Bastos, Gláucia

; Cabral, Mônica

; Pantaleão, André

; Oliveira, Jucinéia

; Meirelles, Ricardo M.R.

Arquivos Brasileiros de Endocrinologia & Metabologia

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feb 2000, Volume 44 N. 1 Pages 21 - 30

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Vários estudos sugerem que existe uma hiperatividade do eixo hipotálamo-hipofisário-adrenal (HHA) na obesidade, com maior acúmulo de gordura na região abdominal. Estes trabalhos demonstram que, após injeções de hormônio liberador de corticotropina (CRF) ou hormônio adrenocorticotrófico (ACTH) e ainda através de testes de stress, os níveis de cortisol estão aumentados em comparação com pacientes com deposição periférica de gordura. Além do mais, alguns estudos mostram que em pacientes deprimidos, onde a hiperatividade do HHA é uma alteração endócrina importante e conhecida, o volume das adrenais está aumentado quando comparado com normais. Para investigar se o teor de gordura visceral de alguma maneira se relaciona com o volume das adrenais, 52 mulheres com idade entre 19 e 54 anos, com diferentes índices de corpulência, foram estudadas através de medidas antropométricas como peso, índice de massa corporal (IMC), cintura e relação cintura-quadril (RCQ). As áreas de gordura visceral (GV) e subcutânea (GSC), além do volume das adrenais, foram medidas através da tomografia computadorizada. Houve uma correlação extremamente significativa entre as medidas de distribuição de gordura (RCQ e cintura) e a GV, sendo que a RCQ não se correlacionou com a GSC. O somatório do volume das adrenais mostrou uma correlação positiva e significativa com a RCQ (r = 0,272, p = 0,02) e uma correlação positiva, mas no limite da significância com a GV (r = 0,228, p = 0,05), não mostrando qualquer correlação com a GSC. Além disso, o somatório do volume das adrenais foi maior naquelas com GV > ou = 120 cm² quando comparado com pacientes com área de GV < 120 cm² (p = 0,05). Portanto, o estudo sugere que o depósito de GV parece inter-relacionar-se com a hiperatividade do HHA, aqui estimada anatomicamente através do volume das adrenais, glândula alvo deste eixo.

Many studies suggest that there is a hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis related to obesity with accumulation of fat in the abdominal region. Some studies demonstrate that after the injection of corticotrophin-releasing hormone (CRH) or corticotrophin (ACTH) and according to the results of stress tests, the levels of cortisol are increased when compared to patients with peripheral fat deposition. Moreover, some studies show that in depressed patients, where the hyperactivity of HPA is known and represents an important endocrinological change, the adrenal volume is increased. To investigate if the amount of visceral fat is related in some way to adrenal gland volume, a group of 52 women with different corpulence indexes was studied. Anthropometries measures, such as weight, body mass index (BMI), waist circumference and waist-to-hip ratio (WHR) were checked. The areas of visceral and subcutaneous fat, as well as adrenal gland volumes, were checked by abdominal computed tomography. There was an extremely relevant correlation between the measurements of central fat deposition (WHR and waist circumference) and the amount of visceral fat (VF), although no correlation was found between the WHR and the subcutaneous fat. The added adrenals volumes showed a positive correlation to the WHR (r = 0.272; p = 0.02) and also to the VF (r = 0.228; p = 0.05). No correlation with the subcutaneous fat, BMI, and weight were found. The added adrenals volumes were increased when VF > or = 120 cm² as compared with patients with VF < 120 cm² (p = 0.05). Thus, this study suggests that the amount of VF seem to be related to the HPA hyperactivity, anatomically expressed in this study by the adrenal volume, the target gland of this axis.

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11.

Walker-Warburg syndrome: report of two cases
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VASCONCELOS, MARCIO M.

; GUEDES, CÁSSIA R.

; DOMINGUES, ROMEU C.

; VIANNA, RAUL N. G.

; SOTERO, MARCIO

; VIEIRA, MÔNICA M.

Arquivos de Neuro-Psiquiatria

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sep 1999, Volume 57 N. 3A Pages 672 - 677

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo é descrever dois lactentes que receberam o diagnóstico de síndrome de Walker-Warburg (WWS), uma forma rara de distrofia muscular congênita (CMD). Investigamos as manifestações clínicas, laboratoriais e neurorradiológicas dos dois pacientes. O caso-índice submeteu-se a uma imagem de ressonância magnética (MRI) cerebral e o segundo paciente a tomografia computadorizada (CT) do crânio. Ademais, realizou-se revisão da literatura para descrever as principais formas de CMD. O caso-índice satisfez todos os critérios de WWS. Uma MRI cerebral realizada aos 4 meses de idade confirmou o diagnóstico clínico ao mostrar hidrocefalia acentuada, lissencefalia do tipo II, agenesia do corpo caloso, aplasia do vermis cerebelar e um tronco encefálico hipoplásico. O diagnóstico de WWS foi estabelecido retrospectivamente na irmã mais velha do caso-índice, com base nos achados clínicos e no laudo da CT do crânio.

The purpose of this study is to describe two infants that were diagnosed with Walker-Warburg syndrome (WWS), a rare form of congenital muscular dystrophy (CMD).They were studied in their clinical, laboratory, and neuroradiologic features. The index case had a brain magnetic resonance imaging (MRI) and the second patient had a head computerized tomography (CT). In addition, a literature review was performed to describe the main forms of CMD. The index case fulfilled all criteria for WWS. A brain MRI performed at age 4 months served to corroborate the clinical diagnosis, showing severe hydrocephalus, type II lissencephaly, cerebellar vermian aplasia, and a hypoplastic brain stem. The authors were able to establish a retrospective diagnosis of WWS in the index case's older sister, based upon her clinical picture and head CT report.

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12.

Isolamento do Toxoplasma gondii de exsudato peritoneal e órgãos de camundongos com infecção experimental
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Jamra, Ligia M. Ferreira

; Vieira, Mônica de Paula L.

Revista do Instituto de Medicina Tropical de São Paulo

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dec 1991, Volume 33 N. 6 Pages 435 - 441

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Foram examinados exsudatos peritoneais e órgãos (cérebro, coração, pulmão e músculo estriado) de 53 camundongos infectados experimentalmente pelo Toxoplasma gondii, sendo 21 na fase aguda e 32 na crônica. Camundongos albinos, machos, de cerca de 25 g e 2 meses de idade foram inoculados, por via intraperitoneal, com 0,5 ml de exsudato peritoneal (taquizoitas) ou macerado de cérebro (cistos) de camundongos previamente infectados. O exame a fresco foi feito no exsudato peritoneal, entre 3 e 12 dias após inoculação e no cérebro, após 10 dias. Foram realizadas inoculações de macerados de órgãos em novos camundongos (repiques) para a recuperação do parasita no exsudato ou no cérebro. Na infecção aguda as positividades foram, ao exame a fresco: exsudato peritoneal 19/19, pulmão 12/14, músculo 6/9, coração 4/9 e cérebro 1/3. Após inoculação: exsudato peritoneal 5/5, cérebro 2/2, coração 19/19, pulmão 13/13 e músculo 14/17. Após estes últimos resultados foram registrados 9 novos órgãos positivos. A positividade final (igual à recuperação do parasita) foi: exsudato peritoneal 19/19 (100%), coração 15/17 (88,5%), músculo 12/14 (85,7%), pulmão 14/14 (100%) e cérebro 2/3 (66,6%). Na infecção crônica, que transcorreu entre 10 e 495 dias, as positividades foram, ao exame a fresco: cérebro 28/32, coração 0/4 e músculo 0/4. Após repique: cérebro 6/6, coração 14/29 e músculo 16/26. Neste exame foi revelado um novo camundongo positivo elevando para 29 o total de camundongos positivos ou 90,6%. O resultado final foi: cérebro 28/32 (87,5%), músculo 16/28 (57,15%) e coração 14/31 (45,1%). No fim da pesquisa, aos 495 dias, o cérebro apresentava grandes cistos ao exame a fresco e coração e músculo mostravam-se positivos através da inoculação. Conclusões: 1º) nos camundongos o toxoplasma persistiu por 495 dias no cérebro, coração e músculo estriado; 2º) o exame a fresco do pulmão pode substituir ou confirmar o do exsudato peritoneal; 3º) a inoculação de órgãos é necessária pois pode revelar novos casos positivos; 4º) a atividade dos cistos foi demonstrada pelo aumento gradual do seu tamanho e pela recuperação do toxoplasma no cérebro, coração e músculo, após o longo tempo de infecção.

Peritoneal exsudates and organs from 53 male albino mice, experimentally infected by Toxoplasma gondii were studied, 21 at the acute phase of infection, and 32 at the chronic phase. Peritoneal inoculations were made with 0,5 ml of peritoneal exsudates (tachyzoites), or brain macerates (cysts) of previously infected mice. Direct examinations of peritoneal exsudates (tachyzoites) were realized between 3 to 12 days post-inoculation, and in brain (cysts) after 10 days post-inoculation. Organs macerates were inoculated in new mice, for the parasite recovering, from exsudates or from brains. At the acute infection (3 to 12 days) the positivity at the direct examination was: peritoneal exsudate 19/19, lung 12/14, muscle 6/9, heart 4/9 and brain 1/3. After inoculation: peritoneal exsudate 5/5, heart 9/9, lung 13/13, muscles 14/17 and brain 2/2. Then, there were 9 new positive organs. At the chronic infection, between 10 and 495 days, the positivity was, at direct examination: brain 28/32, heart 0/4 and muscle 0/4. After inoculation: brain 6/6, heart 14/29 and muscle 16/26. After that a new positive mouse was detected, which leads to 29 the positivity for all mice, or 90,6%. Finally the positivity for the acute phase was: peritoneal exsudate 19/19 (100%), heart 15/17 (88,5%), muscle 12/14 (85,7%), lung 14/14 (100%) and brain 2/3 (66,6%). For the chronic phase: brain 28/32 (87,5%), muscle 16/28 (57,1%) and heart 14/31 (45,1%). At the end of experience, at the 495th day, the brain still presented large cysts by direct examination and also the heart and muscle were positives after inoculation. Conclusions: 1st) on mice the Toxoplasma gondii remained for 495 days, mainly on the brain, but also on heart and muscle; 2nd) the lungs direct examination could be useful as substitute of the peritoneal exsudate examination; 3th) organs inoculations are necessary for the discovery of new infected mice; 4th) the cyst activity was demonstrated by its gradative increase during the chronic infection, and by its recovery in tissues after a long time.

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13.

Ação do sal de cozinha sobre o Toxoplasma gondii
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Jamra, Ligia M. Ferreira

; Martins, Maria Cristina

; Vieira, Monica de Paula L.

Revista do Instituto de Medicina Tropical de São Paulo

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oct 1991, Volume 33 N. 5 Pages 359 - 363

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O baixo resultado encontrado por nós no isolamento do Toxoplasma gondii de embutidos de carne de porco procedentes de Erechim (RS) (uma positiva em 40 amostras) levou-nos a pesquisar a ação do sal de cozinha, presente nesses embutidos, sobre taquizoitas e cistos do parasita. Foram obtidos exsudatos peritoneais (taquizoitas) e macerados de cérebros (cistos) de camundongos previamente inoculados com cepas de Toxoplasma gondii isoladas do material de Erechim. A este inóculo foi acrescentado sal de cozinha refinado, comum, nas concentrações de 2,2%, 2,5% e 3,0% habitualmente usadas no preparo dos embutidos. O tempo de exposição ao sal foi de 24 e 48 horas, 3-5 e 7 dias, a 4ºC, após o qual, camundongos albinos, machos, foram inoculados, por via intraperitoneal, com 0,5 ml desses inóculos, padronizados quanto ao número de parasitas. Os resultados mostraram que, nas concentrações de sal a 2,2%, 2,5% e 3,0% e exposições de 24 e 48 horas, todos os camundongos inoculados com taquizoitas mais sal morreram, menos um, provavelmente não infectado, (um sobrevivente em 28 inoculados). Na concentração de 3,0% e exposição durante 3-5 e 7 dias houve 10 sobreviventes em 37 animais inoculados (27%), sendo que com 5 e 7 dias, 7 de 15 camundongos sobreviveram (46,6%). Nos camundongos inoculados com cistos mais sal a 3,0% e exposições de 24, 48 e 72 horas, faltam anotações dos resultados; com exposições de 5 e 7 dias houve 17 sobreviventes e 3 mortos (85%). Camundongos-controles para cada grupo foram inoculados nas mesmas condições, porem sem o sal. A morte destes ocorreu em 100%, sempre, mais cedo do que a dos camundongos-testes. O toxoplasma foi recuperado do exsudato peritoneal e do cérebro dos camundongos recém-mortos e moribundos, mas nunca dos sobreviventes. Estes resultados evidenciam a ação inativante do sal de cozinha sobre o Toxoplasma gondii, na concentração de 3%, durante um mínimo de 3 dias e, possivelmente, explicam a raridade do isolamento do parasita nos embutidos de carne de porco salgada do inquérito de Erechim.

Results of our inquiry on Toxoplasma gondii frequency in pork sausages from Erechim (RS, Brazil), where the incidence of toxoplasmotic chorioretinitis is high (9% according SILVEIRA, 1987)9, revealed only one isolation of the parasite among 40 sausage samples. (MARTINS, 1989)5,6. The sausages were prepared with pork and common table salt, and were ingested, frequently, in raw stale, during its preparation. In this experiment, table salt action on tachyzoites and cysts of Toxoplasma gondii, was investigated. Albino male mice were intraperitoneally inoculated with 0,5 ml of peritoneal exsudates (tachyzoites) or brain macerates (cysts) from previously infected mice. Some strains were isolated from pork and pork sausages from Erechim. Refined common table salt was added to the inocula at 2,2%, 2,5% and 3,0% concentrations, during 24 and 48 hours, 3-5 and 7 days of exposition time, at 4º C. The results demonstrated that at 2,2%, 2,5% and 3,0% salt concentrations and 24 and 48 hours of time exposition all mice inoculated with tachyzoites were dead, except one, probably not infected. At 3,0% and 3-5 and 7 days of contact, 10 in 37 inoculated mice survived (27%). Of the mice inoculated with cysts plus salt at 3,0%, at 5 and 7 days exposition, 85%; survived (17 in 20). All the controls mice inoculated with the same inocula without salt, at the same conditions, died earlier than the test mice. The Toxoplasma was recovered from peritoneal exsudates and brains of recently dead and diyng mice, but not from the survivors. Conclusion: the table salt has an inactive action on Toxoplasma gondii in 3,0% concentration and at 3 to 7 days exposition. Possibly this may explain the rare isolation of the parasite in pork sausages of Erechim inquiry.

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