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Associação da autopercepção de sentimentos depressivos e do desempenho cognitivo com a prevalência de depressão em idosos quilombolas
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Barros, Eriko Bruno Costa

; Costa, Andréa Suzana Vieira

; Aragão, Francisca Bruna Arruda

; Alves, Gilberto Sousa

; Portela, Yara Maria Cavalcante de

; Oliveira, Bruno Luciano Carneiro Alves de

Revista Brasileira de Geriatria e Gerontologia

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2023, Volume 26 elocation e230076

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective To analyze the association of self-perceived depressive feelings and cognitive performance with prevalence of depressive symptoms among quilombola elderly people. Methods Cross-sectional study conducted with elderly people from 11 communities in Bequimão-MA. Socioeconomic and health conditions, self-perception of depressive feelings, cognitive performance by the Mini-Mental State Examination (MMSE) and prevalence of depressive symptoms by the Geriatric Depression Scale (GDS-30) were investigated. Crude and adjusted prevalence ratios were calculated with a confidence interval of 95% by Poisson regression with robust variance. Results A total of 59.5% of the elderly people were females, 50.6% were up to 69 years old and 83.7% were classified in socioeconomic status E. Moreover, 45.7% reported feeling “down” or “without perspective”; 12.1% had altered cognitive performance and 46.4% were screened as depressed by the GDS-30. Based on the GDS-30, 65.0% of the elderly people reported perception of depressive feelings associated depression, as well as 70% of them showed altered cognitive performance. In the adjusted analysis, depression evaluated by the GDS-30 was associated with self-perceived depressive feelings (PR= 2.02; 95% CI: 1.26-3.26), but not with the MMSE (PR= 1.64; 95% CI: 0.90-3.01). Conclusion There was a high prevalence of self-perceived depressive feelings and depressive symptoms identified by the GDS-30. The association between these variables points to the importance of monitoring the mental health of quilombola elderly people.

Resumo Objetivo Analisar a associação da autopercepção de sentimentos depressivos e desempenho cognitivo comprometido com a prevalência de depressão em idosos quilombolas. Métodos Estudo transversal realizado com 168 idosos de 11 comunidades de Bequimão-MA. Foram investigadas condições socioeconômicas e de saúde, como autopercepção de sentimentos depressivos, desempenho cognitivo comprometido pelo Mini Mental (MEEM) e prevalência de depressão pela Escala de Depressão Geriátrica (GDS-30). Razões de prevalência bruta e ajustada foram calculadas com intervalo de confiança de 95% por regressão de Poisson com variância robusta. Resultados A maioria dos idosos era do sexo feminino (59,5%), tinham até 69 anos (50,6%), não tinham escolaridade (54,2%) e estavam no mais baixo estrato socioeconômico (classe E= 83,7%). O relato de sentir-se “para baixo” ou “sem perspectiva” foi feito por 45,7% dos idosos; 12,1% apresentaram desempenho cognitivo comprometido e 46,4% foram identificados com depressão pela GDS-30. Foram identificados com depressão com base na GDS-30, 65,0% dos idosos que relataram autopercepção de sentimentos depressivos, e 70% daqueles com desempenho cognitivo comprometido. Na análise ajustada por condições socioeconômicas, a depressão avaliada pela GDS-30 esteve associada à autopercepção de sentimentos depressivos (RP= 2,02; IC 95%: 1,26-3,26), mas não ao MEEM (RP= 1,64; IC 95%: 0.90-3.01). Conclusão Verificou-se alta prevalência de autopercepção de sentimentos depressivos e de depressão identificada pela GDS-30. A associação entre essas variáveis aponta para a importância da triagem e manejo da saúde mental dos idosos quilombolas.

https://doi.org/10.1590/1981-22562023026.230076.pt

Mortalidade por Insuficiência Cardíaca durante a Pandemia da COVID-19: Insights de uma Coorte de Hospitais Públicos no Brasil
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Fernandes-Silva, Miguel M.

; Adam, Eduardo Leal

; Bernardez-Pereira, Sabrina

; Silva, Suzana Alves

; Passaglia, Luiz Guilherme

; Pereira, Kleber Renato Ponzi

; Guedes, Marco Antônio Vieira

; Souza Neto, João David de

; Paola, Ângelo Amato Vincenzo de

; Rivera, Maria Alayde Mendonça

; Resende, Elmiro Santos

; Albuquerque, Denilson Campos de

; Bacal, Fernando

; Ribeiro, Antônio Luiz Pinho

; Morgan, Louise

; Smith Jr, Sidney C.

; Taniguchi, Fábio Papa

Arquivos Brasileiros de Cardiologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220080

Social participation and self-assessment of health status among older people in Brazil
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Oliveira, Bruno Luciano Carneiro Alves de

; Lima, Sara Fiterman

; Costa, Andréa Suzana Vieira

; Silva, Alécia Maria da

; Alves, Maria Teresa Seabra Soares de Britto e

Ciência & Saúde Coletiva

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feb 2021, Volume 26 N. 2 Pages 581 - 592

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Estimar a prevalência da participação social (exposição) e sua associação com a autoavaliação positiva do estado de saúde (AAS) (desfecho) de 7.712 idosos entrevistados na Pesquisa Nacional de Saúde 2013. Trata-se de estudo transversal que usou o Escore de Propensão (EP) para melhorar a comparação entre o grupo exposto e não exposto a participação social. Realizou-se regressão de Poisson para determinar a prevalência e associação em estudo com o modelo bruto e ajustado pelo inverso da probabilidade de seleção do EP. A participação social foi referida por 25,1% (IC:95%: 23,4-26,9) e foi menor entre os idosos pobres, que dependem de transporte público e vivem em contextos mais precários. A maioria não avaliou positivamente sua saúde, mas a proporção foi maior quando tem participação social (48,0%; IC95%: 46,0-51,0). Houve associação positiva da participação social com a AAS positiva. A magnitude de associação usando o modelo ajustado (RP: 1,15; IC95%: 1,08-1,22) atenuou a estimada no modelo bruto. Idosos expostos tiveram 15% a mais de chance de referir AAS positiva. Apesar de baixa prevalência no Brasil, houve positiva influência da participação social na avaliação de saúde, confirmando que o engajamento social permite ganhos importantes para a saúde e qualidade de vida.

Abstract To estimate the prevalence of social participation (exposure) and its association with positive self-assessment of overall health status (SAH) (outcome) among 7,712 Brazilian elderly interviewed in the National Health Survey 2013. A cross-sectional study that used Propensity Score (PS) to improve comparability between the group exposed and no exposed to social participation. Poisson regression was performed to determine the prevalence and association of interest using crude and adjusted by inverse probability of selection of PS. Social participation was reported by 25.1% (CI95%: 23.4-26.9) and was lower among poor older people, who depend on public transportation and live in more precarious contexts. Most did not SAH positively, but the proportion was higher when they had social participation (48.0%; CI95%: 46.0-51.0). There was a positive association of social participation with SAH positive. The association using the adjusted model (PR: 1.15; CI95%: 1.08-1.22) attenuated the estimated in the crude model. Elderly exposed were 15% more likely to provide a positive SAH. Despite low levels in Brazil, there was a positive association between of social participation and SAH, confirming that engagement in such activities provides important gains for the health and quality of life.

https://doi.org/10.1590/1413-81232021262.20342019

Social participation and self-assessment of health status among older people in Brazil
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Oliveira, Bruno Luciano Carneiro Alves de

; Lima, Sara Fiterman

; Costa, Andréa Suzana Vieira

; Silva, Alécia Maria da

; Alves, Maria Teresa Seabra Soares de Britto e

Ciência & Saúde Coletiva

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feb 2021, Volume 26 N. 2 Pages 581 - 592

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021262.20342019 588 downloads

The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA

; BACCARO, FABRICIO

; CRONEMBERGER, CECILIA

; HIPÓLITO, JULIANA

; BARROS, CLAUDIA FRANCA

; RODRIGUES, DOMINGOS DE JESUS

; NECKEL-OLIVEIRA, SELVINO

; OVERBECK, GERHARD E.

; DRECHSLER-SANTOS, ELISANDRO RICARDO

; ANJOS, MARCELO RODRIGUES DOS

; FERREGUETTI, ÁTILLA C.

; AKAMA, ALBERTO

; MARTINS, MARLÚCIA BONIFÁCIO

; TOMAS, WALFRIDO MORAES

; SANTOS, SANDRA APARECIDA

; FERREIRA, VANDA LÚCIA

; CUNHA, CATIA NUNES DA

; PENHA, JERRY

; PINHO, JOÃO BATISTA DE

; SALIS, SUZANA MARIA

; DORIA, CAROLINA RODRIGUES DA COSTA

; PILLAR, VALÉRIO D.

; PODGAISKI, LUCIANA R.

; MENIN, MARCELO

; BÍGIO, NARCÍSIO COSTA

; ARAGÓN, SUSAN

; MANZATTO, ANGELO GILBERTO

; VÉLEZ-MARTIN, EDUARDO

; SILVA, ANA CAROLINA BORGES LINS E

; IZZO, THIAGO JUNQUEIRA

; MORTATI, AMANDA FREDERICO

; GIACOMIN, LEANDRO LACERDA

; ALMEIDA, THAÍS ELIAS

; ANDRÉ, THIAGO

; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA

; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA

; MESSIAS, MARILUCE REZENDE

; MARQUES, MARCIA C.M.

; PADIAL, ANDRE ANDRIAN

; MARQUES, RENATO

; BITAR, YOUSZEF O.C.

; SILVEIRA, MARCOS

; MORATO, ELDER FERREIRA

; PAGOTTO, RUBIANI DE CÁSSIA

; STRUSSMANN, CHRISTINE

; MACHADO, RICARDO BOMFIM

; AGUIAR, LUDMILLA MOURA DE SOUZA

; FERNANDES, GERALDO WILSON

; OKI, YUMI

; NOVAIS, SAMUEL

; FERREIRA, GUILHERME BRAGA

; BARBOSA, FLÁVIA RODRIGUES

; OCHOA, ANA C.

; MANGIONE, ANTONIO M.

; GATICA, AILIN

; CARRIZO, MARÍA CELINA

; RETTA, LUCÍA MARTINEZ

; JOFRÉ, LAURA E.

; CASTILLO, LUCIANA L.

; NEME, ANDREA M.

; RUEDA, CARLA

; TOLEDO, JOSÉ JULIO DE

; GRELLE, CARLOS EDUARDO VIVEIROS

; VALE, MARIANA M.

; VIEIRA, MARCUS VINICIUS

; CERQUEIRA, RUI

; HIGASHIKAWA, EMÍLIO MANABU

; MENDONÇA, FERNANDO PEREIRA DE

; GUERREIRO, QUÊZIA LEANDRO DE MOURA

; BANHOS, AUREO

; HERO, JEAN-MARC

; KOBLITZ, RODRIGO

; COLLEVATTI, ROSANE GARCIA

; SILVEIRA, LUÍS FÁBIO

; VASCONCELOS, HERALDO L.

; VIEIRA, CECÍLIA RODRIGUES

; COLLI, GUARINO RINALDI

; CECHIN, SONIA ZANINI

; SANTOS, TIAGO GOMES DOS

; FONTANA, CARLA S.

; JARENKOW, JOÃO A.

; MALABARBA, LUIZ R.

; RUEDA, MARTA P.

; ARAUJO, PUBLIO A.

; PALOMO, LUCAS

; ITURRE, MARTA C.

; BERGALLO, HELENA GODOY

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 N. 2 elocation e20201604

Abstract: En | Text: En | PDF: En

Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.

https://doi.org/10.1590/0001-3765202120201604 1034 downloads

Epidemiologia e desfecho dos pacientes de alto risco cirúrgico admitidos em unidades de terapia intensiva no Brasil
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Silva Júnior, João Manoel

; Chaves, Renato Carneiro de Freitas

; Corrêa, Thiago Domingos

; Assunção, Murillo Santucci Cesar de

; Katayama, Henrique Tadashi

; Bosso, Fabio Eduardo

; Amendola, Cristina Prata

; Serpa Neto, Ary

; Malbouisson, Luiz Marcelo Sá

; Oliveira, Neymar Elias de

; Veiga, Viviane Cordeiro

; Rojas, Salomón Soriano Ordinola

; Postalli, Natalia Fioravante

; Alvarisa, Thais Kawagoe

; Lucena, Bruno Melo Nobrega de

; Oliveira, Raphael Augusto Gomes de

; Sanches, Luciana Coelho

; Silva, Ulysses Vasconcellos de Andrade e

; Nassar Junior, Antonio Paulo

; Réa-Neto, Álvaro

; Amaral, Alexandre

; Teles, José Mário

; Freitas, Flávio Geraldo Rezende de

; Bafi, Antônio Tonete

; Pacheco, Eduardo Souza

; Ramos, Fernando José

; Vieira Júnior, José Mauro

; Pereira, Maria Augusta Santos Rahe

; Schwerz, Fábio Sartori

; Menezes, Giovanna Padoa de

; Magalhães, Danielle Dourado

; Castro, Cristine Pilati Pileggi

; Henrich, Sabrina Frighetto

; Toledo, Diogo Oliveira

; Parra, Bruna Fernanda Camargo Silva

; Dias, Fernando Suparregui

; Zerman, Luiza

; Formolo, Fernanda

; Nobrega, Marciano de Sousa

; Piras, Claudio

; Piras, Stéphanie de Barros

; Conti, Rodrigo

; Bittencourt, Paulo Lisboa

; D’Oliveira, Ricardo Azevedo Cruz

; Estrela, André Ricardo de Oliveira

; Oliveira, Mirella Cristine de

; Reese, Fernanda Baeumle

; Motta Júnior, Jarbas da Silva

; Câmara, Bruna Martins Dzivielevski da

; David-João, Paula Geraldes

; Tannous, Luana Alves

; Chaiben, Viviane Bernardes de Oliveira

; Miranda, Lorena Macedo Araújo

; Brasil, José Arthur dos Santos

; Deucher, Rafael Alexandre de Oliveira

; Ferreira, Marcos Henrique Borges

; Vilela, Denner Luiz

; Almeida, Guilherme Cincinato de

; Nedel, Wagner Luis

; Passos, Matheus Golenia dos

; Marin, Luiz Gustavo

; Oliveira Filho, Wilson de

; Coutinho, Raoni Machado

; Oliveira, Michele Cristina Lima de

; Friedman, Gilberto

; Meregalli, André

; Höher, Jorge Amilton

; Soares, Afonso José Celente

; Lobo, Suzana Margareth Ajeje

Revista Brasileira de Terapia Intensiva

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mar 2020, Volume 32 N. 1 Pages 17 - 27

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Definir o perfil epidemiológico e os principais determinantes de morbimortalidade dos pacientes cirúrgicos não cardíacos de alto risco no Brasil. Métodos: Estudo prospectivo, observacional e multicêntrico. Todos os pacientes cirúrgicos não cardíacos admitidos nas unidades de terapia intensiva, ou seja, considerados de alto risco, no período de 1 mês, foram avaliados e acompanhados diariamente por, no máximo, 7 dias na unidade de terapia intensiva, para determinação de complicações. As taxas de mortalidade em 28 dias de pós-operatório, na unidade de terapia intensiva e hospitalar foram avaliadas. Resultados: Participaram 29 unidades de terapia intensiva onde foram realizadas cirurgias em 25.500 pacientes, dos quais 904 (3,5%) de alto risco (intervalo de confiança de 95% - IC95% 3,3% - 3,8%), tendo sido incluídos no estudo. Dos pacientes envolvidos, 48,3% eram de unidades de terapia intensiva privadas e 51,7% de públicas. O tempo de internação na unidade de terapia intensiva foi de 2,0 (1,0 - 4,0) dias e hospitalar de 9,5 (5,4 - 18,6) dias. As taxas de complicações foram 29,9% (IC95% 26,4 - 33,7) e mortalidade em 28 dias pós-cirurgia 9,6% (IC95% 7,4 - 12,1). Os fatores independentes de risco para complicações foram Simplified Acute Physiology Score 3 (SAPS 3; razão de chance − RC = 1,02; IC95% 1,01 - 1,03) e Sequential Organ Failure Assessment Score (SOFA) da admissão na unidade de terapia intensiva (RC =1,17; IC95% 1,09 - 1,25), tempo de cirurgia (RC = 1,001; IC95% 1,000 - 1,002) e cirurgias de emergências (RC = 1,93; IC95% 1,10 - 3,38). Em adição, foram associados com mortalidade em 28 dias idade (RC = 1,032; IC95% 1,011 - 1,052) SAPS 3 (RC = 1,041; IC95% 1,107 - 1,279), SOFA (RC = 1,175; IC95% 1,069 - 1,292) e cirurgias emergenciais (RC = 2,509; IC95% 1,040 - 6,051). Conclusão: Pacientes com escores prognósticos mais elevados, idosos, tempo cirúrgico e cirurgias emergenciais estiveram fortemente associados a maior mortalidade em 28 dias e mais complicações durante permanência em unidade de terapia intensiva.

ABSTRACT Objective: To define the epidemiological profile and the main determinants of morbidity and mortality in noncardiac high surgical risk patients in Brazil. Methods: This was a prospective, observational and multicenter study. All noncardiac surgical patients admitted to intensive care units, i.e., those considered high risk, within a 1-month period were evaluated and monitored daily for a maximum of 7 days in the intensive care unit to determine complications. The 28-day postoperative, intensive care unit and hospital mortality rates were evaluated. Results: Twenty-nine intensive care units participated in the study. Surgeries were performed in 25,500 patients, of whom 904 (3.5%) were high-risk (95% confidence interval - 95%CI 3.3% - 3.8%) and were included in the study. Of the participating patients, 48.3% were from private intensive care units, and 51.7% were from public intensive care units. The length of stay in the intensive care unit was 2.0 (1.0 - 4.0) days, and the length of hospital stay was 9.5 (5.4 - 18.6) days. The complication rate was 29.9% (95%CI 26.4 - 33.7), and the 28-day postoperative mortality rate was 9.6% (95%CI 7.4 - 12.1). The independent risk factors for complications were the Simplified Acute Physiology Score 3 (SAPS 3; odds ratio - OR = 1.02; 95%CI 1.01 - 1.03) and Sequential Organ Failure Assessment Score (SOFA) on admission to the intensive care unit (OR = 1.17; 95%CI 1.09 - 1.25), surgical time (OR = 1.001, 95%CI 1.000 - 1.002) and emergency surgeries (OR = 1.93, 95%CI, 1.10 - 3.38). In addition, there were associations with 28-day mortality (OR = 1.032; 95%CI 1.011 - 1.052), SAPS 3 (OR = 1.041; 95%CI 1.107 - 1.279), SOFA (OR = 1.175, 95%CI 1.069 - 1.292) and emergency surgeries (OR = 2.509; 95%CI 1.040 - 6.051). Conclusion: Higher prognostic scores, elderly patients, longer surgical times and emergency surgeries were strongly associated with higher 28-day mortality and more complications during the intensive care unit stay.

https://doi.org/10.5935/0103-507x.20200005 1048 downloads

Social inequality and pneumonia hospitalization in children under five years of age in Maranhão, Brazil
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Gaspar, Maria Augusta Ribeiro

; Barros, Pedro Henrique Silva

; Costa, Andréa Suzana Vieira

; Soares, Fabiana Alves

; Oliveira, Bruno Luciano Carneiro Alves de

Revista Brasileira de Saúde Materno Infantil

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mar 2020, Volume 20 N. 1 Pages 81 - 89

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: descrever as características das hospitalizações por pneumonia entre crianças menores de cinco anos de idade no estado do Maranhão e verificar seu padrão de distribuição geoespacial. Métodos: estudo ecológico, com dados ocorridos entre 2012 e 2017, coletados do Sistema de Informações Hospitalares segundo idade, sexo, cor/raça, mês de ocorrência e município de residência. Utilizaram-se também medidas socioeconômicas contextuais dos municípios em 2010. Apresentaram-se as características percentuais das causas de hospitalização do aparelho respiratório e por pneumonia, sua variação temporal ao longo dos meses e as taxas nos anos de estudo. Aplicou-se a estatística G* para verificar a formação de significativos clusters de municípios com similares níveis de hospitalizações. Resultados: a pneumonia foi a principal causa da hospitalização (57%), ocorrendo, frequentemente, nos meses de intensas chuvas (fevereiro a junho) e em cidades com piores indicadores socioeconômicos. As taxas de internação decresceram no período. Significativos agrupamentos (p<0,05) de municípios com maiores proporções de pneumonia ocorreram no sul do estado e com menores na região metropolitana da capital São Luís. Conclusões: a pneumonia foi importante causa de hospitalização de crianças e sua distribuição está associada a características socioeconômicas contextuais, refletido o nível de qualidade de vida e saúde no Maranhão.

Abstract Objectives: to describe the characteristics of pneumonia hospitalizations in children under five years of age across the State of Maranhão, Brazil, and explore patterns of spatial distribution of admissions. Methods: ecological study using data on occurrences (age, gender, skin color/race, month of occurrence, and municipality of residence) between 2012 and 2017 taken from the Unified Health System’s Hospital Information System and municipal level socioeconomic indicators for 2010. Each respiratory disease, including pneumonia, was presented as a percentage of overall admissions for respiratory tract diseases, together with the monthly distribution of admissions as a percentage of total annual cases, and annual rate of admissions by gender. The General G* statistic was calculated to identify significant clustering of municipalities with similar proportions of hospital admissions for pneumonia relative to overall hospital admissions. Results: pneumonia was the leading cause of admissions for respiratory disease, accounting for 57% of all cases and occurring with greater frequency in the rainy season (February to June) and in cities with lower socioeconomic indicator values. The rate of admissions decreased over the study period. Significant clusters (p<0.05) of municipalities with high proportions of hospital admissions for pneumonia relative to overall hospital admissions occurred predominantly in the south of the state, while clusters with low propor-tions were located mainly in and around the metropolitan region of the state capital São Luís. Conclusions: pneumonia was shown to be a key cause of hospitalization in children and its distribution was associated with contextual socioeconomic factors, reflecting the quality of life and health status of children in Maranhão.

https://doi.org/10.1590/1806-93042020000100006 1308 downloads

Investigation of wound healing activity of Lafoensia pacari (Lythraceae) leaves extract cultivated in Goiás state, Brazil
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Chaibub, Beatriz Abdallah

; Parente, Leila Maria Leal

; Lino Jr, Ruy de Souza

; Cirilo, Herica Nubia Cardoso

; Garcia, Sandra Alves de Sousa

; Nogueira, João Carlos Mohn

; Conceição, Edemilson Cardodo da

; Thomaz, Douglas Vieira

; Santos, Suzana da Costa

; Bara, Maria Teresa Freitas

Rodriguésia

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2020, Volume 71 elocation e00992019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Lafoensia pacari é empregada na medicina tradicional no cerrado Brasileiro para tratar feridas. É importante desenvolver estudos para melhor compreender como ocorre a atividade biológica de L. pacari . O objetivo deste estudo foi avaliar a atividade cicatrizante do extrato das folhas de L. pacari em modelo animal. O extrato vegetal foi preparado a partir de plantas oriundas de Goiânia-GO, Brasil. Na avaliação da atividade cicatrizante, foi empregado o modelo de feridas cutâneas em ratos. Análise macroscópica, morfométrica e histológica das feridas também foram realizadas. Na cromatografia de camada delgada foi detectada a presença de taninos hidrolisáveis e na cromatografia líquida de alta eficiência, pôde-se sugerir a presença de elagitaninos. Na avaliação das feridas cutâneas em ratos foi possível observar que o tratamento com extrato de L. pacari a 10% (m/v) proporcionou uma redução no tempo de cicatrização de feridas cutâneas em ratos, com aumento significativo das variáveis envolvidas na cicatrização, como número de vasos sanguíneos e a produção de colágeno. Portanto, este estudo mostra que o potencial cicatrizante de L. pacari pode estar relacionado à presença de elagitaninos, o que corrobora com relatos etnofarmacológicos deste vegetal.

Abstract Lafoensia pacari has been used in traditional folk medicine in Brazilian Cerrado to treat wounds. It is important to develop studies that can clarify how the biological activity of L. pacari occurs. The aim of this study was to evaluate the healing activity of L. pacari leaves extract in an animal model. The extract was prepared from plants cultivated in Goiania-GO, Brazil. The healing activity was assayed using cutaneous wound model in rats, and macroscopic, morphometric and histological analysis of wounds were also conducted. The presence of hydrolysable tannins was detected in thin layer chromatography and in high performance liquid chromatography analysis, may be suggested the presence of ellagitannins. In the evaluation of cutaneous wounds in rats it was possible to observe that the treatment with 10% (w/v) L. pacari extract provided a reduction in the time of cutaneous wound healing, with a significant increase in variables involved in healing, such as the number of blood vessels and collagen production. Therefore, this study shows that L. pacari wound healing potential may be related to the presence of ellagitannins and corroborates to ethnopharmacological reports regarding this plant.

https://doi.org/10.1590/2175-7860202071058 634 downloads

The natural history of pregnancies with prenatal diagnosis of Trisomy 18 or Trisomy 13: Retrospective cases of a 23-year experience in a Brazilian public hospital
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Duque, Julio Alejandro Peña

; Ferreira, Charles Francisco

; Zachia, Suzana de Azevedo

; Sanseverino, Maria Teresa Vieira

; Gus, Rejane

; Magalhães, José Antônio de Azevedo

Genetics and Molecular Biology

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2019, Volume 42 N. 1 Pages 286 - 296

Abstract: En | Text: En | PDF: En

Abstract Trisomy 18 (T18) and trisomy 13 (T13) are polymalformative syndromes associated with a high rate of spontaneous abortions, intrauterine death, and short postnatal life. This study describes the overall outcome in a country where the therapeutic interruption of pregnancy is not available. The medical records of women with prenatal diagnosis of full trisomy of T13 or T18 between October 1994 and October 2017 were analyzed in order to describe their natural outcomes. Thirteen cases of T13 and 29 cases of T18 were included. The miscarriage rate was 9% for T18 and no cases for T13. Intrauterine fetal death occurred in 46% and 52% of cases for T13 and T18, respectively. The rate of live births for T13 was 54%, and the median survival was one day (95% CI -33.55 - 90.40) and 71% died in the first 24 hours of life. The rate of live births for T18 was 37% and the median survival was two days (95% CI -1.89 - 13.17); 90% of the affected babies died within first week of life. For the affected babies reaching the first year of life and for those who lived longer, multiple invasive and expensive procedures were required, without success in prolonging life beyond 180 days. This large series provides information for professionals and women regarding the natural histories of T13 and T18. Results of this study are consistent with those referenced in the literature, emphasizing the need of structured protocols and guidelines aiming early T13 and T18 diagnosis, prenatal care, gestation/parents follow-up, and counseling processes. For those couples with earlier diagnosis, a better follow-up and counseling during the prenatal care lead to the option for a support or palliative management of the newborn. Finally, when the counseling process is appropriate, it becomes easier to take decisions respecting the parent’s autonomy and to look for better outcomes for both, the mother and the fetus.

https://doi.org/10.1590/1678-4685-gmb-2018-0099 2062 downloads

10.

No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza Vieira

; Apostolos-Pereira, Samira L.

; Arruda, Walter Oleschko

; Brooks, Joseph B. Bidin

; Cal, Henrique S. Rodrigues

; Damasceno, Carlos A. Albuquerque

; Gama, Paulo Diniz

; Goncalves, Marcus V. Magno

; Jesus, Carlos A. da Silva de

; Machado, Suzana C. Nunes

; Mansur, Letícia Fezer

; Matta, Andre P. da Cunha

; Mendes, Maria Fernanda

; Morales, Rogerio Rizo

; Nobrega-Jr, Adaucto Wanderley da

; Parolin, Monica K. Fiuza

; Peres, Mario Pietro

; Ribeiro, Marlise de Castro

; Ruocco, Heloisa Helena

; Scherpenhuijzen, Simone

; Siquinelli, Fabio

; Stoney, Patrick N.

; Varela, Daniel Lima

; Eboni, Audred Cristina Biondo

; Spessotto, Caroline Vieira

; Rocha, Elisa Teixeira da

; Lacerda, Pamela Emanuele

Arquivos de Neuro-Psiquiatria

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jan 2017, Volume 75 N. 1 Pages 3 - 8

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Vitamina D assumiu um papel central na pesquisa e tratamento da esclerose múltipla (EM). O objetivo deste estudo foi avaliar os níveis séricos de vitamina D de pacientes com EM e controles que residem em uma área tropical. Métodos: Foram analisados dados de 535 pacientes com EM e 350 indivíduos controle em 14 cidades próximas ao Trópico de Capricórnio. Resultados: O valor médio da determinação de 25-OH vitamina D foi 26,07 ± 10,27 ng/mL para controles e 28,03 ± 12,19 ng/mL para pacientes com EM. Não houve correlação entre os níveis de vitamina D e o grau de incapacidade ao longo da duração da doença. Conclusão: Pelo menos na região que cerca o Trópico de Capricórnio, os níveis séricos de vitamina D estão entre valores de 20 a 30 ng/mL tanto para controles quanto para pacientes com EM.

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

https://doi.org/10.1590/0004-282x20160173 3011 downloads

11.

Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats
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CIRANO, Fabiano Ribeiro

; CASARIN, Renato Correa Viana

; RIBEIRO, Fernanda Vieira

; CASATI, Marcio Zaffalon

; PIMENTEL, Suzana Peres

; TAIETE, Tiago

; BERNARDI, Maria Martha

Brazilian Oral Research

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2016, Volume 30 N. 1 elocation e128

Abstract: En | Text: En | PDF: En

Abstract The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days. Then, the presence and concentrations of Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans in the cotton ligatures collected from the first molars were evaluated using real-time PCR. Inter-group comparisons of the microbiological outcomes revealed that no differences were detected for P. gingivalis, T. forsythia and A. actinomycetemcomitans levels (p > 0.05). Continuous use of resveratrol did not promote additional benefits in microbiological outcomes during experimental periodontitis in rats.

https://doi.org/10.1590/1807-3107bor-2016.vol30.0128 2349 downloads

12.

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome
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Fröhlich, Alan Christmann

; Eckeli, Alan Luiz

; Bacelar, Andrea

; Poyares, Dalva

; Pachito, Daniela Vianna

; Stelzer, Fernando Gustavo

; Coelho, Fernando Morgadinho Santos

; Rizzo, Geraldo Nunes Vieira

; Prado, Gilmar Fernandes do

; Sander, Heidi Haueisen

; Goulart, Leonardo Ierardi

; Lucchesi, Ligia Mendonça

; Gitai, Lívia Leite Góes

; Prado, Lucila Bizari Fernandes do

; Ataíde-Junior, Luiz

; Bezerra, Marcio Luciano de Souza

; Lopes, Maria Cecília

; Trentin, Marine Meliksetyan

; Rodrigues, Raimundo Nonato Delgado

; Hasan, Rosa

; Alves, Rosana S. Cardoso

; Schönwald, Suzana Veiga

; Moraes, Walter André dos Santos

Arquivos de Neuro-Psiquiatria

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mar 2015, Volume 73 N. 3 Pages 260 - 280

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O Consenso em síndrome das pernas inquietas contou com a participação de neurologistas de vários estados brasileiros, os quais incansavelmente revisaram a literatura dos últimos anos em busca de evidências, tanto no que se refere ao diagnóstico como ao tratamento, de acordo com a Classificação do Centro de Oxford para Medicina Baseada em Evidências.

The Consensus on restless legs syndrome is an effort of neurologists from several Brazilian states, which tirelessly reviewed the literature of recent years in search of evidence, both in regard to diagnosis and treatment, according to the Oxford Centre for Evidence-based Medicine.

https://doi.org/10.1590/0004-282X20140239 7813 downloads

13.

Adaptação transcultural brasileira do â€œFamily caregiver-specific quality of life scaleâ€�: estudo metodológico
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Vieira, Gláucia Cristina Andrade

; Cavalcanti, Ana Carla Dantas

; Silva, Suzana Alves da

; Guimarães, Tereza Cristina Felippe

; Rosa, Maria Luiza Garcia

; Silva, Vanessa Alves da

Online Brazilian Journal of Nursing

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2014, Volume 13 N. 1 Pages 53 - 61

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Aim: To perform a transcultural adaptation of the Family Caregiver-Specific Quality of Life Scale to be used in Brazil. Method: A simple, easily applicable questionnaire was applied, composed of 16 questions, subdivided into the physical, psychological, social and spiritual domains, which was originally tested on a population composed of caregivers for heart failure patients. In this methodological study, the process of adaptation involved the translation, synthesis of translations, back translation and a committee of evaluators. Results: After the translation process, the committee of evaluators suggested some changes to the questionnaire that were authorized by its original author. Discussion: The questionnaire was considered pertinent to Brazilian culture, and to adequately represent the target-population, as well as presenting a good semantic equivalence between the final version in Portuguese and the original version. Conclusion: The instrument has proven to be sufficiently adequate to be used in the general population, and it has also been psychometrically validated.

Objetivo: Realizar la adaptación transcultural del Family Caregiver-Specific Quality of Life Scale para usarlo en Brasil. Método: El cuestionario es simple, de fácil aplicación, compuesto por 16 cuestiones subdivididas en los temas físicos, psicológicos, social y espiritual habiendo sido validado originalmente en una población de cuidadores de pacientes con insuficiencia cardíaca. En este estudio metodológico, el proceso de adaptación involucró la traducción, síntesis de traducciones, retro traducción y un comité de jueces. Resultados: Después de las etapas de traducción, el comité de jueces sugirió modificaciones en el cuestionario que fueron autorizadas por la autora del cuestionario original. Discusión: El cuestionario se consideró pertinente a la cultura brasileña y sus elementos adecuados en relación a su capacidad de representar la población a la cual está destinado, además de presentar buena equivalencia semántica entre la versión final en portugués y la original. Conclusión: El instrumento resultó adecuado para ser utilizado en la población y se está validando psicométricamente.

Objetivo: Realizar adaptação transcultural do Family Caregiver-Specific Quality of Life Scale para uso no Brasil. Método: O questionário é simples, de fácil aplicação, composto por 16 questões subdivididas nos domínios físico, psicológico, social e espiritual, tendo sido validado originalmente em uma população de cuidadores de pacientes com insuficiência cardíaca. Neste estudo metodológico, o processo de adaptação envolveu a tradução, síntese das traduções, retrotradução e comitê de juízes. Resultados: Após as etapas de tradução, o comitê de juízes sugeriu modificações no questionário que foram autorizadas pela autora do questionário original Discussão: O questionário foi considerado pertinente à cultura brasileira e seus itens adequados quanto à sua capacidade de representar à população-alvo, além de apresentar boa equivalência semântica entre a versão final em português e a original. Conclusão: O instrumento mostrou-se adequado para ser utilizado na população e está sendo validado psicometricamente.

25 downloads

14.

Estado nutricional de adolescentes do Maranhão, Brasil, por critérios nacional e internacional
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Costa, Andréa Suzana Vieira

; Chein, Maria Bethânia da Costa

; Tonial, Sueli Rosina

; Gama, Mônica Elinor Alves

; Martins, Maylla Luanna Barbosa

; Cunha, Carlos Leonardo Figueiredo

; Silva, Diego Salvador Muniz da

; Cruz, Paulo Roberto Silva

; Brito, Luciane Maria Oliveira

Ciência & Saúde Coletiva

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dec 2013, Volume 18 N. 12 Pages 3715 - 3720

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo objetivou comparar os critérios nacional e internacional para avaliação do estado nutricional de adolescentes. Realizou-se um estudo transversal e analítico, no período de julho de 2007 a janeiro de 2008, com uma amostra representativa do estado do Maranhão composta por 1.256 adolescentes. O índice de massa corporal (IMC) por gênero e idade foi utilizado para diagnosticar baixo peso, peso adequado e excesso de peso, empregando-se os critérios propostos por Conde e Monteiro e pela Organização Mundial de Saúde (OMS). Foram aplicados testes qui-quadrados, concordância de McNemar e correlação de Spearman. Segundo os critérios de Conde e Monteiro e da OMS, houve diferenças significativas entre os meninos quanto ao baixo peso e obesidade. Observou-se que não houve discordância significativa entre os dois critérios. Constatou-se uma correlação positiva e significativa (0,011) entre os dois critérios. Com esta análise pode-se perceber que não há muitas discordâncias entre os critérios utilizados, portanto não podemos apontar o melhor critério e as vantagens de se utilizar um ou outro. Contudo, vale ressaltar que o critério nacional também pode ser mais utilizado, já que não tem diferenças significativas com aquele preconizado pelo Ministério da Saúde, da OMS.

This study sought to compare national and international criteria for assessing the nutritional status of adolescents. A cross-sectional analytical study was conducted in the period from July 2007 to January 2008 with a representative sample comprised of 1256 adolescents from the state of Maranhão. Body mass index (BMI) for age and gender was used to diagnose underweight, normal weight and overweight, using the criteria proposed by Conde and Monteiro and the World Health Organization (WHO). Chi-square, McNemar concordance and Spearman correlation tests were applied. According to the criteria of Conde and Monteiro and the WHO, there were significant differences among the boys with respect to low weight and obesity. It was observed that there was no significant divergence between the two criteria, and a significant positive correlation (0.011) between the two criteria was detected. With this analysis it can be seen that there are many divergences between the criteria used, therefore the best option and the advantage of using one or the other cannot be singled out. However, it should be stressed that the national criterion can also be used more, since there are no significant differences with the criteria advocated by the Ministry of Health of the WHO.

2883 downloads

15.

Estado nutricional de adolescentes do Maranhão, Brasil, por critérios nacional e internacional
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Costa, Andréa Suzana Vieira

; Chein, Maria Bethânia da Costa

; Tonial, Sueli Rosina

; Gama, Mônica Elinor Alves

; Martins, Maylla Luanna Barbosa

; Cunha, Carlos Leonardo Figueiredo

; Silva, Diego Salvador Muniz da

; Cruz, Paulo Roberto Silva

; Brito, Luciane Maria Oliveira

Ciência & Saúde Coletiva

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dec 2013, Volume 18 N. 12 Pages 3715 - 3720

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/S1413-81232013001200027 1534 downloads

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