The bottom drainage roadway plays a crucial role in preventing coal and gas outbursts by using underground gas drainage methods. Therefore, it is essential to select the ideal position of the bottom drainage roadway. In this paper use a combination of geological data and numerical simulation to study the ideal position of the bottom drainage roadway, we taking the gas drainage of the first workface of No. 3 coal seam in the Yuxi coal mine in China as an example. The geological study showed a limestone marker layer at an average vertical distance of 14 m from the first mining face. Using this marker layer, the bottom drainage roadway could be excavated without the risk of accidentally exposing the coal seam, and less crosscutting borehole drilling from the bottom drainage roadway would be required. Based on the needs of gas control, the layout of the bottom drainage roadway was selected as an external stagger type. Combined with the numerical simulation results, when located 20 m outside of the mining workface 'footprint' on the horizontal projection, the bottom drainage roadway was a sufficient distance from the stress concentration area during mining of workface 1301, which facilitated roadway maintenance. Furthermore, the length of the crosscutting boreholes is also relatively short, which reduces the amount and cost of drilling. The results of this study are expected to provide a reference for the selection of an ideal position of the bottom drainage roadway in field engineering.

To extend the variety of lump ores that are used in the COREX shaft furnace and to optimize iron ore blending, the original evaluation method for iron ores that was proposed by Voestalpine AG has been improved. Physicochemical and metallurgical properties of iron ores, including Sishen lump ore and CVRD pellets, which are currently used in the COREX process, and three other lump ores, were assessed and compared. Ore matching principles were proposed and five optimized iron ore blending schemes designed and verified by laboratory experiments to prove the effectiveness of the improved evaluation method. The replacement of Sishen lump ore by the alternative L2 and L3 lump ores without varying the proportion of CVRD pellets could improve the degree of reduction and rate of metallization, and decrease the bonding index. Based on the results of laboratory test work and industrial- trials, an ore blending scheme of 60% CVRD, 20% L2, and 20% L3 is recommended for use in the COREX process.

Mineral homeostasis is often disrupted in intrauterine growth retardation (IUGR) infants. Most studies focus on calcium or phosphorus metabolism of IUGR infants via determining serum mineral concentrations instead of tissues. This study was conducted to investigate the effects of IUGR on the mineralization and physiological functions of tissue in a piglet model. Six normal birth weight (NBW) and six IUGR neonatal piglets were slaughtered at 35 days. Mineral concentrations in blood and selected tissues (liver, kidney, lungs, heart, and longissimus dorsi muscle (LDM)), hepatic lipid, mRNA expressions of magnesium (Mg) metabolism, and autophagy were analysed. Results showed that IUGR pigs showed significantly lower phosphorus (P) in LDM, and lower Mg in the liver and LDM, and higher Mg in lungs than NBW pigs. There were no significant differences in concentrations of selenium (Se), calcium (Ca), copper (Cu), aluminium (Al), and lithium (Li) in selected tissues. IUGR pigs had similar mRNA expression of TRPM7 and MagT1 to NBW pigs, but significantly lower expressions of HNF1B and Mrs2 in the liver than NBW pigs. Hepatic triglyceride was significantly increased, and MAP1LC3B expression was significantly decreased in IUGR pigs compared with those of NBW pigs. These result suggested that IUGR pigs had tissue mineralization disturbance, especially for Mg, and liver dysfunction (increased hepatic lipid and inhibited autophagy). Hepatic Mg deficiency might result from increased Mg efflux via reducing HNF1B expression.

The objective of this study was to observe the infection of human cytomegalovirus (HCMV) to human umbilical vein endothelial cells, and its effect on the expression of single-stranded DNA-binding protein (SSBP1) and on lipid metabolism in endothelial cells. We screened the differential expression of mRNAs after HCMV infection by suppression subtractive hybridization and the expression levels of SSBP1 mRNA and protein after HCMV infection by real-time PCR and western blot. After verification of successful infection by indirect immunofluorescent staining and RT-PCR, we found a differential expression of lipid metabolism-related genes including LDLR, SCARB, CETP, HMGCR, ApoB and LPL induced by HCMV infection. The expression levels of SSBP1 mRNA and protein after HCMV infection were significantly down-regulated. Furthermore, we found that upregulation of SSBP1 inhibited the expression of atherosclerosis-associated LDLR, SCARB, HMGCR, CETP as well as the accumulation of lipids in the cells. The results showed that the inhibition of SSBP1 by HCMV infection promotes lipid accumulation in the cells.

Glucagon-like peptide 1 (GLP-1), a kind of gut hormone, is used in the treatment of type 2 diabetes (T2D). Emerging evidence indicates that GLP-1 has anti-inflammatory activity. Chronic inflammation in the adipose tissue of obese individuals is a cause of insulin resistance and T2D. We hypothesized that GLP-1 analogue therapy in patients with T2D could suppress the inflammatory response of macrophages, and therefore inhibit insulin resistance. Our results showed that GLP-1 agonist (exendin-4) not only attenuated macrophage infiltration, but also inhibited the macrophage secretion of inflammatory cytokines including TNF-β, IL-6, and IL-1β. Furthermore, we observed that lipopolysaccharide (LPS)-induced macrophage conditioned media could impair insulin-stimulated glucose uptake. This effect was compensated by treatment with the conditioned media from macrophages treated with the combination of LPS and exendin-4. It was also observed that exendin-4 directly inhibited the activation of NF-κB in macrophages. In conclusion, our results indicated that GLP-1 improved inflammatory macrophage-derived insulin resistance by inhibiting NF-κB pathway and secretion of inflammatory cytokines in macrophages. Furthermore, our observations suggested that the anti-inflammatory effect of GLP-1 on macrophages can contribute to GLP-1 analogue therapy of T2D.

The AZ31 magnesium alloy tube was used for electromagnetic forming experiment of three kinds of input voltages. The stress-strain state of tube forming was analyzed. It was shown that the cause of oblique crack of tube was σr of axial inhomogeneous distribution and σz, and the cause of longitudinal crack was σr and σè of inhomogeneous distribution in circumferential direction. Moreover, the electromagnetic field and force field during electromagnetic forming was simulated by ANSYS software. The experiment proved the simulation result.

A method of bulk liquid membrane using complex of (S, S)-di-n-dodecyltartrate and boric acid was developed for the enantioselective transport of racemic propranolol. It was shown that l - propranolol can be effectively transported. The enantioselectivity of the complex for a specific propranolol enantiomer in BLM systems is mainly based on kinetics and is not thermodynamically driven. The effects of the concentration ratio of propranolol to chiral carrier and the buffer pH were studied, respectively. An appropriate choice for such concentration ratio and the pH in the aqueous solution result to be 1 : 20 and 5, respectively. The developed method is helpful for optimizing the transport of bulk liquid membrane systems and realizing the large-scale production of pure enantiomer.

The balance of body fluids is critical to health and the development of diseases. Although quite a few review papers have shown that several mechanisms, including hormonal and behavioral regulation, play an important role in body fluid homeostasis in adults, there is limited information on the development of regulatory mechanisms for fetal body fluid balance. Hormonal, renal, and behavioral control of body fluids function to some extent in utero. Hormonal mechanisms including the renin-angiotensin system, aldosterone, and vasopressin are involved in modifying fetal renal excretion, reabsorption of sodium and water, and regulation of vascular volume. In utero behavioral changes, such as fetal swallowing, have been suggested to be early functional development in response to dipsogens. Since diseases, such as hypertension, can be traced to fetal origin, it is important to understand the development of fetal regulatory mechanisms for body fluid homeostasis in this early stage of life. This review focuses on fetal hormonal, behavioral, and renal development related to regulation of body fluids in utero.

N,N'-Bis(salicylidene)ethylenediiminocobalt (Cosalen) was encapsulated into the supercage of microporous NaY zeolite via "ship-in-a-bottle" technique. The impregnated Cosalen complex immobilized on the outer surface of the zeolite was also prepared in order to further prove the encapsulation by the flexible ligand method. The samples were characterized by FT-IR, UV-Vis, XRD, TG/DTA and SEM techniques. The oxidation of cyclohexane using oxygen was chosen to evaluate the catalytic performance of encapsulated complex. The encapsulated Cosalen was stable than the neat Cosalen complex and the conversion of cyclohexane reached 24.4% at 130 ºC for 3 h in the CH3CN solution without adding any inducing agents. The higher selectivity for acid including adipic acid indicated that the encapsulated Cosalen exhibited the ability to produce acid from cyclohexane by one-step reaction.

Distribution of magnetic field during electromagnetic continuous casting of hollow billets of aluminum alloys is studied by the method of numerical simulation. Two-dimensional axis-symmetric finite element model including water-cooled core, outer mould, ingot, inner and outer induction coil has been established. Distribution of magnetic flux density is obtained by solving magnetic vector potential formulations. 1) In electromagnetic casting, inner and outer induction coil interact, magnitude and admeasurements of current affect directly distribution of magnetic flux density. 2) Magnetic flux density near interior surface of pipe wall is increased notablely by increasing appropriately frequency. 3) Phase difference affects the magnitude and direction of the gradient of magnetic flux density.

Mn in GaAs substitutes Ga as a p dopant and introduces a localized magnetic moment of 5<img src="http:/img/fbpe/bjp/v32n2a/a54img01.gif" align="absMiddle">/2. Ga1–xMn xAs (for x <FONT FACE=Symbol>»</font> 0.04) has been proved to be an extremely interesting material, for its intrincated transport and magnetic properties. In the first part of this work a structure is considered in which a series of Ga1–xMn xAs layers is grown inside a GaAs quantum well. The electron-electron interaction through a Hartree potential, together with the magnetic interaction with the DMS layers (assumed in the ferromagnetic phase) produces an e effctive potential corresponding to a sequence of small barriers which depend (height and width) on the hole spin orientation. For a large number of such layers it is shown that the model structure approaches a magnetic superlattice. A self-consistent calculation is performed for the electronic structure, resulting into spin-polarized energy levels. The polarized miniband Bloch transport properties are calculated for different structural arrangements. In the second part we calculate the transversal spin polarized current induced by an applied voltage through an AlAs/Ga1–xMn xAs/AlAs double barrier heterostructure (DBH). The magnetic layer is assumed in its metallic and ferromagnetic phase. As a consequence of the magnetic interaction a strong polarization of the hole subbands inside the quantum well. In that case the resonant tunneling occurs at different voltages for different spin orientation (parallel or anti-parallel to the average magnetization of Ga1–xMn xAs) throughout. Based on a many-body field quantization formalism that makes use of the tight binding method we obtain, in an essentially exact way, an analytic expression for the spin polarized tunneling current and the escape rate from the right barrier of the DBH. The characteristic spin polarized I(V) curves, as well as the relaxation times, are obtained for different hole concentrations and magnetic layer widths, providing important informations for the possibility of building spin valves made those materials.

Using the balance of forces in the linear regime, it is shown that the ratio between the induced voltage in an open circuit Coulomb drag experiment, and the induced current in closed circuit, equals the internal resistence of the circuit in which the induction occurs.