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As equações de Maxwell são fundamentais para a compreensão dos fenômenos eletromagnéticos, pois descrevem a totalidade dos eventos eletromagnéticos verificados experimentalmente a partir de suas condições de contorno e das relações constitutivas. Embora sejam normalmente apresentados no domínio do espaço e do tempo, muitos efeitos físicos e suas manipulações matemáticas são mais fáceis de entender quando usamos as equações de Maxwell no espaço de Fourier. Neste trabalho é apresentada uma introdução geral sobre as equações de Maxwell no domínio de Fourier em meios materiais. É enfatizada a simplicidade das equações obtidas em comparação com as do domínio espaço-tempo, bem como explorada a ligação entre elas e as excitações elementares em sólidos. Em particular, é explicado o acoplamento entre vários tipos de quasipartículas em sólidos. constitutivas tempo materiais espaçotempo, espaçotempo espaço-tempo sólidos particular

Maxwell’s equations are fundamental to the understanding of electromagnetic events, as they describe the totality of experimentally verified electromagnetic phenomena from its boundary conditions and constitutive relations. Although, they are normally presented in the time and space domain, many physical effects and their associated mathematical manipulation are easier to understand when we use Maxwell’s equations in Fourier space. In this work we give a general introduction about Maxwell’s equations in Fourier domain in material media. The simplicity of the obtained equations in comparison with the ones in space-time domain is emphasized, and the link between them and the elementary excitations in solids is presented and explored. In particular, the coupling between various types of quasiparticles in solids is explained. Maxwells Maxwell s events relations Although media spacetime emphasized explored particular explained

https://doi.org/10.1590/1806-9126-rbef-2023-0076

Antifungal activity of a novel 3-Alkylpyridine analog derived from Marine sponge alkaloids
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ANDRADE, JÉSSICA T.

; LIMA, WILLIAM G.

; BARBOSA, CAMILA S.

; GONÇALVES, ALESSANDRA M.M.N.

; SILVA, MAYRA K.P.

; MORAIS, FERNANDA B.

; PALUMBO, JULIANA M.C.

; VIANA, GUSTAVO H.R.

; FERREIRA, JAQUELINE M.S.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20200944

Resumo: En | Texto: En | PDF: En

Abstract Candida spp. is considered an important cause of healthcare-associated infections worldwide. Currently, the emergence and spread of resistant Candida isolates are being increasingly reported, making the development of new agents urgently needed. In this study, we showed the in vitro anti-Candida activity of seven synthetic 3-alkylpyridine alkaloid analogs. Among them, alkaloid 1 presented a potent antifungal effect, which was independent of its capacity of binding with the fungal membrane ergosterol or cell wall. Analog 1 showed fungistatic and fungicidal effects against C. albicans (MIC 7.8 μg/mL and MFC 62.5 μg/mL), C. glabrata, C. krusei (MIC and MFC 31.2 μg/mL), and C. tropicalis (MIC 31.2 μg/mL and MFC 125 μg/mL). The time kill-curve study showed that compound 1 has a potent fungicidal effect in vitro, eliminating C. albicans cells. Furthermore, an in vitro synergistic effect with ketoconazole was observed for compound 1. This compound also eliminated the yeast-to-hypha transition. However, it showed high cytotoxicity against mammalian cells. Taken together, these findings support the use of compound 1 as a prototype to develop new anti-Candida agents, but molecular modifications should be done to minimize the high cytotoxicity obtained.

https://doi.org/10.1590/0001-3765202120200944 1 downloads

Association of coronary calcification with prognosis of Covid-19 patients without known heart disease
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Possari, R.Y.

; Andrade-Gomes, H.J.

; Mello, V.C.

; Galdeano, E.A.

; Aguiar-Filho, L.F.

; Bittencourt, M.S.

; Ponte, E.V.

; Bertoche, L.R.

; Caio, L.R.S.

; Rodrigues, J.D.

; Alcantara, F.B.

; Freitas, M.A.C.

; Sarinho, J.C.G.C.

; Cervigne, N.K.

; Rodrigues, W.M.

; Aprahamian, I.

Brazilian Journal of Medical and Biological Research

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2021, Volume 54 Nº 12 elocation e11681

Resumo: En | Texto: En | PDF: En

Risk factors that determine the severity of Covid-19 have not been fully elucidated. The aim of this study was to evaluate the role of coronary artery calcification (CAC) as a risk factor for death or mechanical ventilation (MV) of patients without known heart disease infected with Covid-19. We analyzed 283 consecutive in-patients with acute respiratory symptoms with chest computed tomography (chest-CT), without previous heart disease, and criteria for Covid-19 (RT-PCR positive and/or typical clinical and chest-CT findings). CAC was classified by the number of coronary segments affected as absent (0), mild (1-3), and severe calcification (more than 3). The association between CAC, CAC severity, and death or MV due to severe respiratory failure was assessed by logistic regression. The mean age was 58.7±15.7 years and 54.1% were men. Patients with CAC were older, more likely to have hypertension, and less likely to be obese. CAC was present in 75 patients (26.5%), of which 42 had a mild calcification and 33 had severe calcification, and was associated with death (OR=2.35, 95%CI: 1.01-5.48) or MV (OR=2.72, 95%CI: 1.20-6.20) adjusted for multiple confounders, with significant and increased odds ratio for the severe form of CAC (death: OR=3.70, 95%CI: 1.20-11.42; MV: OR=3.30, 95%CI: 1.09-9.95). We concluded that CAC was an independent risk factor for death or MV in Covid-19 patients without previous heart disease, particularly for those with severe calcification. CAC can be easily visualized on common chest-CT, widely used in evaluation of moderate to severe Covid-19.

https://doi.org/10.1590/1414-431x2021e11681 1 downloads

Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model
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THIRUPATHI, ANAND

; SORATO, HELEN R.

; SILVA, PAULO R.L.

; DAMIANI, ADRIANI P.

; ANDRADE, VANESSA M.

; SILVEIRA, PAULO C.L.

; NESI, RENATA T.

; PAULA, MARCOS M.S.

; PINHO, RICARDO A.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 2 elocation e20191450

Resumo: En | Texto: En | PDF: En

Abstract Muscle overuse and its consequent muscle damage has no cure. Therefore, the present study aimed to investigate the regulatory role of tau-AuNPs on muscle recovery of muscle overuse model. The animals (Male Swiss mice) were randomly divided into four groups: Control (Ctr; n=6); tau-AuNPs (n=6); overuse (n=6); and overuse plus tau-AuNPs (n=6). Exercise sessions were performed for 21 consecutive days, and one exercise model was applied daily in the following sequence: low intensity, moderate intensity, and high intensity. The mice were then sacrificed. The quadriceps muscles were surgically removed for subsequent biochemical analysis (oxidative stress parameters, DNA damage markers and muscle differentiation protein). The overuse group significantly increased the oxidative stress parameters and DNA damage markers, whereas tau-AuNPs significantly decreased the oxidative stress parameters in the overuse animal model. However, there were no significant differences observed between overuse group and overuse plus tau-AuNPs administrated group in relation to DNA damage markers including DNA damage frequency and index levels when compared to control and tau-AuNPs groups. Muscle differentiation protein Myf-5 was increased in the overuse plus tau-AuNPs administration group when compared to control group. In conclusion, tau-AuNPs had significant effect on reducing oxidative stress parameters and increasing myogenic regulatory protein Myf-5 in the overuse group. However, it did not have significant effect on reducing DNA damage.

https://doi.org/10.1590/0001-3765202120191450 150 downloads

Olfactory and taste disorders in COVID-19: a systematic review
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Costa, Klinger V.T. da

; Carnaúba, Aline Tenório Lins

; Rocha, Katianne Wanderley

; Andrade, Kelly Cristina Lira de

; Ferreira, Sonia M.S.

; Menezes, Pedro de L.

Brazilian Journal of Otorhinolaryngology

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Dez 2020, Volume 86 Nº 6 Páginas 781 - 792

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: O vírus SARS-CoV-2 causa a COVID-19 e é responsável pela maior pandemia desde o surto de influenza H1N1 de 1918. Os sintomas clássicos da doença já foram bem definidos pela Organização Mundial da Saúde; entretanto, distúrbios olfativo-gustativos têm sido relatados em alguns estudos, mas ainda com várias lacunas no entendimento e no consenso sobre a condução clínica desses casos. Objetivo: Identificar evidências na literatura científica sobre os distúrbios olfativo-gustativos acerca da apresentação clínica, prevalência e possíveis tratamentos específicos associados à COVID-19. Método: Revisão sistemática de artigos publicados até 25 de abril de 2020 nas bases de dados: Medline, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus e Google Schoolar, OpenGrey.eu, DissOnline, The New York Academy of Medicine e Research Gate. Foram critérios de inclusão: 1) Estudos com indivíduos com COVID-19; 2) Registro dos sinais/sintomas da COVID-19 e das funções olfativo-gustativa. Foram critérios de exclusão: 1) Estudos sobre coronavírus não humano; 2) Artigos de revisão; 3) Estudos experimentais (em animais ou in vitro); 4) Distúrbios olfativos-gustativos iniciados previamente à infecção pelo SARS-CoV-2. A avaliação de risco de viés dos estudos selecionados foi feita por meio da escala de Newcastle-Ottawa. Resultados: Seis artigos dos 1.788 registros foram selecionados. Um total de 1.457 pacientes de diversas etnias foi avaliado; desses, 885 (60,7%) apresentaram perda do olfato e 822 (56,4%) perda do paladar, sendo as mulheres as mais afetadas. Os distúrbios olfativo-gustativos estiveram presentes mesmo sem obstrução nasal/rinorreia e com início mesmo antes dos sinais/sintomas clínicos da COVID-19; a recuperação do olfato/paladar, quando ocorre, geralmente se dá nas duas primeiras semanas após a resolução da doença. Há evidências de que os distúrbios olfativo-gustativos sejam fortes preditores de infecção pelo SARS-CoV-2, podendo-se recomendar o isolamento do paciente, já a partir da consulta médica, para evitar a disseminação do vírus. Não foram identificadas evidências científicas para tratamentos eficazes para qualquer dos distúrbios. Conclusão: Podem ocorrer distúrbios olfativo-gustativos em intensidades variáveis e prévios aos sintomas gerais da COVID-19, devem ser considerados como parte dos sintomas da doença, mesmo em quadros leves. Não há ainda evidências científicas de tratamentos específicos para tais distúrbios na COVID-19.

Abstract Introduction: The SARS-CoV-2 virus causes COVID-19, and it is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The classic symptoms of the disease have been well defined by the World Health Organization; however, olfactory/gustatory disorders have been reported in some studies, but there are still several missing points in the understanding and in the consensus about the clinical management of these cases. Objective: To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19. Methods: A systematic review of articles published up to April 25, 2020 was performed in Medline, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus and Google Schoolar, OpenGrey.eu, DissOnline, The New York Academy of Medicine and Reasearch Gate. Inclusion criteria: (1) Studies on patients with COVID-19; (2) Records of COVID-19 signs/symptoms, and olfactory/gustatory functions. Exclusion criteria: (1) Studies on non-human coronavirus; (2) Review articles; (3) Experimental studies (in animals or in vitro); (4) Olfactory/gustatory disorders initiated prior to SARS-CoV-2 infection. The risk assessment of bias of the selected studies was performed using the Newcastle-Ottawa scale. Results: Six articles from the 1788 records met the inclusion criteria and were analyzed. A total of 1457 patients of different ethnicities were assessed; of them, 885 (60.7%) and 822 (56.4%) had smell and taste disorders, respectively, with women being most often affected. There were olfactory/gustatory disorders even without nasal obstruction/rhinorrhea and beginning even before the signs/symptoms of COVID-19; the recovery of smell/taste, when it occurs, usually happened in the first two weeks after COVID-19 resolution. There is evidence that olfactory/gustatory disorders are strong predictors of infection by SARS-CoV-2, and it is possible to recommend patient isolation, as early as of the medical consultation, preventing the spread of the virus. No scientific evidence has been identified for effective treatments for any of the disorders. Conclusion: Olfactory/gustatory disorders may occur at varying intensities and prior to the general symptoms of COVID-19 and should be considered as part of the clinical features of COVID-19, even in mild cases. There is still no scientific evidence of specific treatments for such disorders in COVID-19 disease.

https://doi.org/10.1016/j.bjorl.2020.05.008 3776 downloads

Characterization of dyspnea in chronic diseases and heart failure in patients in a Family Health Program
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Ceron, Diana M.M.

; Rosa, Maria Luiza Garcia

; Jorge, Antônio J.L.

; Correia, Dayse M.S.

; Kang, Hye C.

; Mesquita, Evandro T.

; Velasco, Julio César Grijalba

; Gismondi, Ronaldo

; Martins, Wolney de Andrade

Revista Colombiana de Cardiología

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Fev 2020, Volume 27 Nº 1 Páginas 13 - 19

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción: La disnea es el síntoma más común en la insuficiencia cardíaca. En los ancianos es común en la enfermedad pulmonar obstructiva crónica y la depresión. Objetivo: Estimar la prevalencia de disnea de esfuerzo, ortopnea y disnea paroxística nocturna y su asociación con enfermedades crónicas en la atención primaria. Métodos: Estudio transversal, parte del estudio Digitalis, que incluyó a 633 individuos, entre 45 y 99 años de edad, registrados en un programa de atención primaria en Niterói, Brasil. Todos los participantes se sometieron a evaluaciones clínicas, recolección de sangre y orina, y respondieron a un cuestionario en un solo día. Se usaron autorrelatos para el diagnóstico de las enfermedades. Resultados: De los 633 individuos, el 30% presentó disnea. En el análisis crudo la enfermedad pulmonar obstructiva crónica mostró las asociaciones más fuertes con los tres tipos de disnea, seguidos por la depresión y la insuficiencia cardíaca. La enfermedad pulmonar obstructiva crónica, evaluada de forma aislada, no presentó ningún caso de disnea paroxística nocturna, y la insuficiencia cardíaca por sí sola mostró una relación muy fuerte con este tipo de disnea. Conclusiones: El comportamiento diferente de las asociaciones de los tipos de disnea con las principales enfermedades crónicas en pacientes en atención primaria puede ayudar a una mejor caracterización de los pacientes con insuficiencia cardíaca.

Abstract Background: Dyspnea is the most common symptom in heart failure. In the elderly, it is common in chronic obstructive pulmonary disease and depression. Objective: To estimate the prevalence of dyspnea on exertion, orthopnea and paroxysmal nocturnal dyspnea and its association with chronic diseases in primary care. Methods: A cross-sectional study, part of the Digitalis Study, including 633 individuals, between 45 to 99 years old, registered in a primary care program in Niteroi, Brazil. All participants underwent clinical evaluations, blood and urine collection, and responded to a questionnaire in a single day. Self-reports were used for the diagnosis of diseases. Results: Of the 633 individuals, 30% had dyspnea. In the crude analysis, chronic obstructive pulmonary disease showed the strongest associations with the three types of dyspnea, followed by depression and heart failure. Chronic obstructive pulmonary disease alone did not present any cases of paroxysmal nocturnal dyspnea, and heart failure alone showed a very strong relationship with this type of dyspnea. Conclusions: The different behavior of the associations of the types of dyspnea with major chronic diseases in patients in primary care can help in the better characterization of patients with heart failure.

https://doi.org/10.1016/j.rccar.2019.07.008 539 downloads

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
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Ferreira, Juliana C.

; Ho, Yeh-Li

; Besen, Bruno A.M.P.

; Malbuisson, Luiz M.S.

; Taniguchi, Leandro U.

; Mendes, Pedro V.

; Costa, Eduardo L.V.

; Park, Marcelo

; Daltro-Oliveira, Renato

; Roepke, Roberta M.L.

; Silva Jr, João M.

; Carmona, Maria José C.

; Carvalho, Carlos Roberto Ribeiro

; Hirota, Adriana

; Kanasiro, Alberto Kendy

; Crescenzi, Alessandra

; Fernandes, Amanda Coelho

; Miethke-Morais, Anna

; Bellintani, Arthur Petrillo

; Canasiro, Artur Ribeiro

; Carneiro, Bárbara Vieira

; Zanbon, Beatriz Keiko

; Batista, Bernardo Pinheiro De Senna Nogueira

; Nicolao, Bianca Ruiz

; Besen, Bruno Adler Maccagnan Pinheiro

; Biselli, Bruno

; Macedo, Bruno Rocha De

; Toledo, Caio Machado Gomes De

; Pompilio, Carlos Eduardo

; Carvalho, Carlos Roberto Ribeiro De

; Mol, Caroline Gomes

; Stipanich, Cassio

; Bueno, Caue Gasparotto

; Garzillo, Cibele

; Tanaka, Clarice

; Forte, Daniel Neves

; Joelsons, Daniel

; Robira, Daniele

; Costa, Eduardo Leite Vieira

; Silva Júnior, Elson Mendes Da

; Regalio, Fabiane Aliotti

; Segura, Gabriela Cardoso

; Marcelino, Gustavo Brasil

; Louro, Giulia Sefrin

; Ho, Yeh-Li

; Ferreira, Isabela Argollo

; Gois, Jeison de Oliveira

; Silva Junior, Joao Manoel Da

; Reusing Junior, Jose Otto

; Ribeiro, Julia Fray

; Ferreira, Juliana Carvalho

; Galleti, Karine Vusberg

; Silva, Katia Regina

; Isensee, Larissa Padrao

; Oliveira, Larissa dos Santos

; Taniguchi, Leandro Utino

; Letaif, Leila Suemi

; Lima, Lígia Trombetta

; Park, Lucas Yongsoo

; Chaves Netto, Lucas

; Nobrega, Luciana Cassimiro

; Haddad, Luciana

; Hajjar, Ludhmila

; Malbouisson, Luiz Marcelo

; Pandolfi, Manuela Cristina Adsuara

; Park, Marcelo

; Carmona, Maria José Carvalho

; Andrade, Maria Castilho Prandini H De

; Santos, Mariana Moreira

; Bateloche, Matheus Pereira

; Suiama, Mayra Akimi

; Oliveira, Mayron Faria de

; Sousa, Mayson Laercio

; Louvaes, Michelle

; Huemer, Natassja

; Mendes, Pedro

; Lins, Paulo Ricardo Gessolo

; Santos, Pedro Gaspar Dos

; Moreira, Pedro Ferreira Paiva

; Guazzelli, Renata Mello

; Reis, Renato Batista Dos

; Oliveira, Renato Daltro De

; Roepke, Roberta Muriel Longo

; Pedro, Rodolpho Augusto De Moura

; Kondo, Rodrigo

; Rached, Samia Zahi

; Fonseca, Sergio Roberto Silveira Da

; Borges, Thais Sousa

; Ferreira, Thalissa

; Cobello Junior, Vilson

; Sales, Vivian Vieira Tenório

; Ferreira, Willaby Serafim Cassa

Clinics

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2020, Volume 75 elocation e2294

Resumo: En | Texto: En | PDF: En

OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.

https://doi.org/10.6061/clinics/2020/e2294 1957 downloads

Evaluation of equine corneal endothelium after exposure to 0.05% brilliant blue - an in vitro study
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Andrade, M.C.C.

; Moreno, T.M.

; Muccillo, M.S.

; Pigatto, J.A.T.

; Camilo, E.V.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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Ago 2019, Volume 71 Nº 4 Páginas 1158 - 1164

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se avaliar os efeitos imediatos de uma solução de 0,05% de azul brilhante sobre o endotélio da córnea de equinos. Trinta e oito córneas de 19 cavalos, machos ou fêmeas, de diferentes idades foram estudadas. As córneas foram divididas aleatoriamente em dois grupos. Grupo 1: O endotélio corneano foi perfundido com 0,3mL de azul brilhante 0,05% durante 60 segundos seguido por irrigação com uma solução salina balanceada. Grupo 2: O endotélio corneano foi perfundido com BSS durante 60 segundos. As córneas foram posteriormente excisadas com trépano de 8mm e preparadas para análise endotelial utilizando um microscópio óptico (24 córneas) e um microscópio eletrônico de varredura (14 córneas). A análise da superfície posterior do endotélio da córnea equina observada por microscopia óptica e microscopia eletrônica de varredura revelou uma camada contínua de células poligonais de tamanho e forma uniformes tanto no grupo controle quanto no grupo tratamento. Devido aos resíduos não normais na comparação da média de ANOVA, utilizou-se um modelo linear generalizado com nível de significância de 5%. Evidenciou-se com o teste qui-quadrado que não houve diferença estatística entre o grupo controle e o grupo tratamento. O azul brilhante de 0,05% não causou dano ao endotélio corneano de equinos.

ABSTRACT The aim of this study was to evaluate the immediate effects of 0.05% brilliant blue on corneal endothelium of horses. Thirty-eight corneas of 19 horses, male or female, of different ages were studied. Corneas were randomly divided into two groups. Group 1: Corneal endothelium was covered with 0.3mL of brilliant blue 0.05% for 60 seconds followed by rinsing with a balanced salt solution. Group 2: Corneal endothelium was covered with BSS for 60 seconds. The corneas were excised with an 8mm trephine and prepared to analyze posterior endothelial surface using a light microscope (24 corneas) and a scanning electron microscope (14 corneas). The equine posterior corneal endothelium surface observed by optical microscopy and scanning electron microscopy revealed a continuous layer of polygonal cells of uniform size and shape in both the control and treatment groups. Due to non-normal residuals at ANOVA mean comparison, a generalized linear model was utilized at 5% level of significance. The chi-square test stated that treatment and control group were not different statistically. The 0.05% brilliant blue did not cause damage to equine corneal endothelium.

https://doi.org/10.1590/1678-4162-9969 638 downloads

Antioxidant activity of oily extract obtained from Lippia origanoides improves the quality of bovine embryos produced in vitro
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Sollecito, N.V.

; Pereira, E.C.M.

; Grázia, J.G.V.

; Neves, B.P.

; Couto, B.V.R.

; Andrade, V.B.

; Miranda, M.S.

; Silva, J.K.R.

; Borges, A.M.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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Jun 2019, Volume 71 Nº 3 Páginas 723 - 731

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo desse estudo foi avaliar a suplementação de meio de cultura de embriões com antioxidante obtido do extrato oleoso da Lippia origanoides no desenvolvimento e na qualidade de blastocistos produzidos in vitro. Oócitos coletados de ovários de matadouros foram maturados e fertilizados in vitro segundo procedimento laboratorial padrão. Zigotos foram cultivados em meio SOF suplementado de acordo com os seguintes tratamentos: T1) meio de cultivo embrionário sem suplementação antioxidantes; T2) 50μM/mL Cisteamina; T3) 2,5μg/mL; T4) 5,0μg/mL e T5) 10,0μg/mL do antioxidante obtido do extrato oleoso de Lippia origanoides. No sétimo dia de cultivo, os blastocistos foram fixados e avaliados para taxa de apoptose, número total de células e massa celular interna através do teste TUNEL. O uso de antioxidantes durante cultivo não aumentou (P>0,05) a taxa de produção final de blastócitos. Os tratamentos T2, T3, T4 e T5 tiverem menor índice apoptótico (p>0,05 - 4,5±1,1%, 8,4±2,5%, 3,4±1,1% e 5,5±0,9%, respectivamente) quando comparados a T2 (10,0±1,4%). O valor de massa celular interna não diferenciou (p>0,05) entre embriões de diferentes tratamentos. A adição de antioxidante obtido do extrato oleoso de Lippia origanoides reduziu a taxa de apoptose e melhorou a qualidade sem aumentar a produção in vitro de embriões bovinos.

ABSTRACT The aim of this study was to evaluate the supplementation of embryo culture medium with antioxidant obtained from oily extract of Lippia origanoides on in vitro blastocyst development and quality. Oocytes collected from slaughterhouse ovaries were matured and fertilized in vitro following standard laboratory procedures. Zygotes were cultured in SOF medium supplemented according to the following treatments: T1 embryo culture medium without antioxidant supplementation; T2)50μM/mL Cysteamine; T3)2.5μg/mL; T4)5.0μg/mL and T5)10.0μg/mL of antioxidant obtained from oily extract of Lippia origanoides. On the seventh day of culture, the blastocysts were fixed and evaluated for apoptosis rates, number of total cell and inner cell mass cells by means of the TUNEL Test. The use of antioxidants during cultivation did not increase (P> 0.05) the final blastocyst production rate. The treatments T2, T3, T4 and T5 had the lowest (P< 0.05) apoptotic indexes (4.5±1.1%, 8.4±2.5%, 3.4±1.1% and 5.5±0.9%, respectively) when compared to T1 treatment (10.0±1.4%). The number of inner cell mass did not differ (P> 0.05) among embryos from different treatments. The addition of antioxidant obtained from oily extract of Lippia origanoides reduces the apoptosis rate and improves the quality without increasing the total in vitro production of bovine embryos.

https://doi.org/10.1590/1678-4162-10323 1006 downloads

10.

Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance
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HERRERA, KARINA M.S.

; FERREIRA, LORENA S.

; BRAGA, ALYSSON V.

; SOUZA, JULIANO P.

; ANDRADE, JÉSSICA T.

; SOARES, ADRIANA C.

; SOARES, LUIS F.

; CHAGAS, RAFAEL C.R.

; FERREIRA, JAQUELINE M.S.

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2019, Volume 91 Nº 4 elocation e20181077

Resumo: En | Texto: En | PDF: En

Abstract: Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism.

https://doi.org/10.1590/0001-376520181077 750 downloads

11.

Prospective cohort analyzing risk factors for chronic kidney disease progression in children,
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Belangero, Vera M.S.

; Prates, Liliane C.

; Watanabe, Andreia

; Schvartsman, Benita S.G.

; Nussenzveig, Paula

; Cruz, Natalia A.

; Abreu, Ana L.S.

; Paz, Isabel P.

; Facincani, Inalda

; Morgantetti, Fernanda E.C.

; Silva, Andreia O.

; Andrade, Olberes V.B.

; Camargo, Maria F.C.

; Nogueira, Paulo C. Koch

Jornal de Pediatria

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Out 2018, Volume 94 Nº 5 Páginas 525 - 531

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Identificar os fatores de risco para progressão da DRC em crianças do Brasil e avaliar as interações entre os fatores. Métodos: Coorte prospectiva multicêntrica em São Paulo, envolvendo 209 crianças com DRC em estágios 3-4. O desfecho do estudo incluiu: a) óbito, b) início da terapia de substituição renal, c) redução de > 50% na taxa estimada de filtração glomerular (eGFR) durante o acompanhamento. Foram testados 13 fatores de risco com o modelo de regressão univariada seguido do modelo de regressão multivariado de Cox. Os termos de interação entre as variáveis mostraram associação significativa e foram introduzidos ao modelo. Resultados: Após média de acompanhamento de 2,5 anos (IIQ = 1,4 a 3,0), 44 casos (21%) apresentaram desfecho: 22 iniciaram diálise, 12 apresentaram redução de > 50% na eGFR, sete foram submetidos a transplante e três morreram. Estágio avançado de DRC no acometimento (RR = 2,16, IC = 1,14-4,09), proteinúria nefrótica (RR = 2,89, IC = 1,49-5,62), idade (RR - 1,10, IC = 1,01-1,17), escore Z da pressão arterial sistólica (RR = 1,36, IC = 1,08-1,70) e anemia (RR = 2,60, IC - 1,41-4,77) foram associados ao resultado. Foi detectada interação entre anemia e proteinúria nefrótica na primeira visita (V1) (RR = 0,25, IC = 0,06-1,00). Conclusões: Como a primeira coorte de DRC no hemisfério sul, este estudo é concordante com os principais fatores relatados em países desenvolvidos com relação à progressão da DRC, afirmando o possível papel dos tratamentos para mostrar a evolução da DRC. A interação detectada sugere que a anemia pode ser mais nociva na progressão da DRC em pacientes sem proteinúria e deve ser ainda mais estudada.

Abstract Objective: To identify risk factors for chronic kidney disease progression in Brazilian children and to evaluate the interactions between factors. Methods: This was a multicenter prospective cohort in São Paulo, involving 209 children with CKD stages 3-4. The study outcome included: (a) death, (b) start of kidney replacement therapy, (c) eGFR decrease >50% during the followup. Thirteen risk factors were tested using univariate regression models, followed by multivariable Cox regression models. The terms of interaction between the variables showing significant association with the outcome were then introduced to the model. Results: After a median follow-up of 2.5 years (IQR = 1.4-3.0), the outcome occurred in 44 cases (21%): 22 started dialysis, 12 had >50% eGFR decrease, seven underwent transplantation, and three died. Advanced CKD stage at onset (HR = 2.16, CI = 1.14-4.09), nephrotic proteinuria (HR = 2.89, CI = 1.49-5.62), age (HR = 1.10, CI = 1.01-1.17), systolic blood pressure Z score (HR = 1.36, CI = 1.08-1.70), and anemia (HR = 2.60, CI = 1.41-4.77) were associated with the outcome. An interaction between anemia and nephrotic proteinuria at V1 (HR = 0.25, CI = 0.06-1.00) was detected. Conclusions: As the first CKD cohort in the southern hemisphere, this study supports the main factors reported in developed countries with regards to CKD progression, affirming the potential role of treatments to slow CKD evolution. The detected interaction suggests that anemia may be more deleterious for CKD progression in patients without proteinuria and should be further studied.

https://doi.org/10.1016/j.jped.2017.07.015 1352 downloads

12.

The influence of a protocol of aquatic exercises in postural control of obese elderly
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Avelar, I.S.

; Soares, V.

; Barbosa, R.C.

; Andrade, S.R.

; Silva, M.S.

; Vieira, M.F.

Revista Andaluza de Medicina del Deporte

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Jun 2018, Volume 11 Nº 2 Páginas 69 - 74

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

Abstract Objective: The objective of this study was to evaluate the effects of a protocol of aquatic exercises in postural control of elderly subjects with overweight and the influence of body mass and body mass index in variables of the center of pressure. Method: Each participant was positioned on the force platform, without shoes, feet apart on the same alignment of the upper limbs along the body. For the collection, the subjects were instructed to stay on in bipedal support on the force platform with eyes fixed on the bright spot for 60 s. Results: Results indicated a notable difference in the variables root mean square-mediolateral and COP area after aquatic exercise practice. However, visual condition analyzed indicates significant differences in the variables root mean square-anteroposterior and speed anteroposterior. Conclusion: Aquatic exercise had positive effects when analyzing the sensory condition suggesting maintenance of postural control. However, when analyzed post aquatic exercise in closed eyes condition and the interaction effects of visual condition did not improve postural stability. In obese elderly, body mass index resulted in a functional adaptation in control of upright stance, suggesting that the balance was preserved in the population studied.

Resumo Objetivo: O objetivo deste estudo foi avaliar os efeitos do protocolo de exercícios aquáticos no controle postural de idosos com excesso de peso, e a influência de variáveis de massa corporal e índice de massa corporal no centro de pressão. Método: Cada participante foi posicionado sobre a plataforma de força, sem sapatos, pés alinhados, braços ao longo do corpo. Durante a coleta, os indivíduos foram orientados a permanecer sobre a plataforma de força, com os olhos fixos no ponto brilhante durante 60 segundos. Resultados: Os resultados indicaram uma diferença significativa nas variáveis: área do centro de pressão e média quadrática-mediolateral, após a prática de exercício aquático. No entanto, a análise da condição visual sugere diferenças significativas nas variáveis: média quadrática anteroposterior e velocidade anteroposterior. Conclusão: Os exercícios aquáticos tiveram efeitos positivos sobre a análise sugerido pela condição da manutenção do controle postural. No entanto, quando analisados em condição de olho fechado após o exercício aquático e os efeitos da interação da condição visual, não melhoram a estabilidade postural. Em obesos idosos, o índice de massa corporal resultou numa adaptação funcional para controlar a posição vertical, o que sugere que o equilíbrio foi mantido na população estudada.

Resumen Objetivo: El objetivo de este estudio fue evaluar los efectos de un protocolo de ejercicios acuáticos en el control postural de sujetos de edad avanzada con exceso de peso y la influencia de masa corporal y el índice de masa corporal en las variables del centro de presiones. Método: Cada participante se posicionó en la plataforma de fuerza sin zapatos, los pies separados con la misma alineación de las extremidades superiores a lo largo del cuerpo. Para el análisis, los sujetos fueron instruidos para permanecer en apoyo bípedo sobre la plataforma de fuerza con los ojos fijos en un punto brillante durante 60 segundos. Resultados: Los resultados indicaron una diferencia notable en las variables: Media Cuadrática-Mediolateral y el Área descrita por el desplazamiento del centro de presiones, después de la práctica de ejercicio acuático. Sin embargo, la condición visual analizada indica diferencias significativas en las variables: Media Cuadrática Anteroposterior y Velocidad Anteroposterior. Conclusión: El ejercicio acuático tuvo efectos positivos en el análisis de la condición sensorial sugiriendo el mantenimiento del control postural. Sin embargo, cuando se analizan la condición de ojo cerrado tras el ejercicio acuático y los efectos de la interacción de la condición visual no mejoró la estabilidad postural. En obesos de edad avanzada, el índice de masa corporal resultó en una adaptación funcional en el control de la postura vertical, lo que sugiere que el equilibrio se conservó en la población estudiada.

https://doi.org/10.1016/j.ramd.2016.01.003 453 downloads

13.

Antibacterial activity of Lamiaceae plant extracts in clinical isolates of multidrug-resistant bacteria
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ASSIS, FELIPE V. DE

; SIQUEIRA, FLÁVIA L.

; GONÇALVES, ISABELA E.

; LACERDA, RAFAEL P.

; NASCIMENTO, RAFAELA A.

; ARAÚJO, STHÉFANE G.

; ANDRADE, JÉSSICA T.

; HERRERA, KARINA M.S.

; LIMA, LUCIANA A.R.S.

; FERREIRA, JAQUELINE M.S.

Anais da Academia Brasileira de Ciências

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Abr 2018, Volume 90 Nº 2 Páginas 1665 - 1670

Resumo: En | Texto: En | PDF: En

ABSTRACT The antibacterial activity of plant extracts of the Lamiaceae family was evaluated against clinical isolates of multi-resistant Gram-negative bacteria by broth microdilution technique. Promising results were obtained considering that all extracts were active for at least two bacterial species with MIC ranging from 0.5 to 2.0 mg/mL.

https://doi.org/10.1590/0001-3765201820160870 2230 downloads

14.

Serra Pelada: the first Amazonian Meteorite fall is a Eucrite (basalt) from Asteroid 4-Vesta
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ZUCOLOTTO, MARIA ELIZABETH

; TOSI, AMANDA A.

; VILLAÇA, CAIO V.N.

; MOUTINHO, ANDRÉ L.R.

; ANDRADE, DIANA P.P.

; FAULSTICH, FABIANO

; GOMES, ANGELO M.S.

; RIOS, DEBORA C.

; ROCHA, MARCILIO C.

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Mar 2018, Volume 90 Nº 1 Páginas 3 - 16

Resumo: En | Texto: En | PDF: En

ABSTRACT Serra Pelada is the newest Brazilian eucrite and the first recovered fall from Amazonia (State of Pará, Brazil, June 29th 2017). In this paper, we report on its petrography, chemistry, mineralogy and its magnetic properties. Study of four thin sections reveals that the meteorite is brecciated, containing basaltic and gabbroic clasts, as well of recrystallized impact melt, embedded into a fine-medium grained matrix. Chemical analyses suggest that Serra Pelada is a monomict basaltic eucritic breccia, and that the meteorite is a normal member of the HED suite. Our results provide additional geological and compositional information on the lithological diversity of its parent body. The mineralogy of Serra Pelada consists basically of low-Ca pyroxene and high-Ca plagioclase with accessory minerals such as quartz, sulphide (troilite), chromite - ulvöspinel and ilmenite. These data are consistent with the meteorite being an eucrite, a basaltic achondrite and a member of the howardite-eucrite-diogenite (HED) clan of meteorites which most likely are from the crust asteroid 4 Vesta.

https://doi.org/10.1590/0001-3765201820170854 3243 downloads

15.

Association between postpartum depression and the practice of exclusive breastfeeding in the first three months of life,
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Silva, Catarine S.

; Lima, Marilia C.

; Sequeira-de-Andrade, Leopoldina A.S.

; Oliveira, Juliana S.

; Monteiro, Jailma S.

; Lima, Niedja M.S.

; Santos, Rijane M.A.B.

; Lira, Pedro I.C.

Jornal de Pediatria

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Ago 2017, Volume 93 Nº 4 Páginas 356 - 364

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Verificar a associação entre a depressão pós-parto e a ocorrência do aleitamento materno exclusivo. Método: Estudo de corte transversal feito nos estados da Região Nordeste, durante a campanha de vacinação de 2010. A amostra consistiu de 2.583 binômios mães-crianças entre 15 dias e três meses. Usou-se a Escala de Depressão Pós-Parto de Edimburgo para rastrear a depressão pós-parto. O desfecho consistiu da ausência de aleitamento materno exclusivo nas 24 horas que antecederam a entrevista. A depressão pós-parto foi variável explanatória de interesse e as covariáveis foram: condições socioeconômicas e demográficas, assistência pré-natal, ao parto e pós-natal e fatores da criança. Fez-se análise de regressão logística multivariada com o objetivo de controlar possíveis fatores de confusão. Resultados: A amamentação exclusiva foi observada em 50,8% das crianças e 11,8% das mulheres apresentaram sintomatologia indicativa de depressão pós-parto. Na análise de regressão logística multivariada foi verificada uma maior chance de ausência do aleitamento materno exclusivo entre as mães com sintomas de depressão pós-parto (OR = 1,67; p < 0,001). Conclusões: A depressão pós-parto contribuiu para redução da prática do aleitamento materno exclusivo. Assim, esse transtorno deveria ser incluído nas orientações de apoio desde o pré-natal e nos primeiros meses pós-parto, especialmente em mulheres de baixo nível socioeconômico.

Abstract Objective: To investigate the association between postpartum depression and the occurrence of exclusive breastfeeding. Method: This is a cross-sectional study conducted in the states of the Northeast region, during the vaccination campaign in 2010. The sample consisted of 2583 mother-child pairs, with children aged from 15 days to 3 months. The Edinburgh Postnatal Depression Scale was used to screen for postpartum depression. The outcome was lack of exclusive breastfeeding, defined as the occurrence of this practice in the 24 h preceding the interview. Postpartum depression was the explanatory variable of interest and the covariates were: socioeconomic and demographic conditions; maternal health care; prenatal, delivery, and postnatal care; and the child's biological factors. Multivariate logistic regression analysis was conducted to control for possible confounding factors. Results: Exclusive breastfeeding was observed in 50.8% of the infants and 11.8% of women had symptoms of postpartum depression. In the multivariate logistic regression analysis, a higher chance of exclusive breastfeeding absence was found among mothers with symptoms of postpartum depression (OR = 1.67; p < 0.001), among younger subjects (OR = 1.89; p < 0.001), those who reported receiving benefits from the Bolsa Família Program (OR = 1.25; p = 0.016), and those started antenatal care later during pregnancy (OR = 2.14; p = 0.032). Conclusions: Postpartum depression contributed to reducing the practice of exclusive breastfeeding. Therefore, this disorder should be included in the prenatal and early postpartum support guidelines for breastfeeding, especially in low socioeconomic status women.

https://doi.org/10.1016/j.jped.2016.08.005 8817 downloads

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