Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group. However, we synthesised nitroimidazoles with activity against the trypomastigotes of Trypanosoma cruzi, but that were not genotoxic. Herein, nitroimidazoles (11-19) bearing different substituent groups were investigated for their potential induction of genotoxicity (comet assay) and mutagenicity (Salmonella/Microsome assay) and the correlations of these effects with their trypanocidal effect and with megazol were investigated. The compounds were designed to analyse the role played by the position of the nitro group in the imidazole nucleus (C-4 or C-5) and the presence of oxidisable groups at N-1 as an anion receptor group and the role of a methyl group at C-2. Nitroimidazoles bearing NO2 at C-4 and CH3 at C-2 were not genotoxic compared to those bearing NO2 at C-5. However, when there was a CH3 at C-2, the position of the NO2 group had no influence on the genotoxic activity. Fluorinated compounds exhibited higher genotoxicity regardless of the presence of CH3 at C-2 or NO2 at C-4 or C-5. However, in compounds 11 (2-CH3; 4-NO2; N-CH2OHCH2Cl) and 12 (2-CH3; 4-NO2; N-CH2OHCH2F), the fluorine atom had no influence on genotoxicity. This study contributes to the future search for new and safer prototypes and provide.

A couve-chinesa é uma hortaliça que apresenta alto valor nutricional, sendo a escolha de genótipos adaptados às condições locais importante para o sucesso do seu cultivo. Assim, o presente trabalho teve como objetivo avaliar o desempenho de cultivares de couve-chinesa cultivadas em condições de altas temperaturas. O experimento foi conduzido na área experimental pertencente à Universidade do Estado de Mato Grosso, em Cáceres-MT, de 8 de abril a 23 de junho de 2011. O delineamento experimental utilizado foi de blocos ao acaso com cinco repetições, sendo avaliadas sete cultivares Granat, Michihilli, Kyoto, Seijin F1, Kinjitsu, AF 74 e AF 66. Avaliou-se o número de plantas pendoadas por parcela, produtividade, peso, diâmetro e altura da cabeça, comprimento do caule, altura da planta, número de folhas da saia e compacidade. Constatou-se que não houve diferença estatística, quanto à produtividade; entretanto, para a produção comercial a cultivar AF 66 apresentou melhor desempenho. A cultivar Seijin apresentou o maior diâmetro da cabeça (13,2 cm). Para altura das plantas os resultados foram inversamente proporcionais ao diâmetro da cabeça. A cultivar Michihilli apresentou a maior média para comprimento do caule (17,4 cm), visto que esta se encontrava com 9,1% das plantas florescida no dia da colheita. A cultivar AF 66 obteve-média de 4,3 para compacidade da cabeça. O número de folhas da saia foi em média 15 para a cultivar Kyoto. Entre as cultivares avaliadas, a AF 66 apresentou o melhor resultado com boa adaptação para a região de Cáceres-MT.

The Chinese cabbage is a vegetable with high nutritional value. The choice for adapted genotypes to local conditions is important to provide success in its cultivation. Thereby, we evaluated the performance of Chinese cabbage cultivars grown under high temperature conditions. The experiment was carried out in the Universidade Estadual do Mato Grosso, in Cáceres, Mato Grosso state, Brazil, from April 8th to June 23rd, 2011. The experimental design was randomized blocks with five replications. Seven cultivars were evaluated (Granat, Michihilli, Kyoto, Seijin F1 Kinjitsu, AF 74 and AF 66). We evaluated the number of bolted plants, productivity (PT) (t/ha), weight of head (g/plant), head diameter (cm), head height (cm), stem length (cm), plant height (cm), number of leaves of the skirt, and compactness. We found no statistical difference regarding productivity. AF 66 showed a better performance for head production. Seijin presented the highest head diameter (13.2 cm). Plant height results were inversely proportional to the head diameter. Cultivar Michihilli had the highest average value for stem length (17,4 cm), considereing 9.1% of plants flowered on the day of harvest. For head compactness we obtained a score of 4.3 for the cultivar AF 66. 'Kyoto' averaged 15 discarded leaves regarding the number of leaves of the skirt. Among the studied cultivars, AF 66 presented the best result, also showing good adaptation to the hot climate of Caceres.