Pesquisa | SciELO

RESUMO OBJETIVO Estimar a soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares de quatro a 14 anos de idade residentes no município de São Paulo, segundo variáveis clínicas, demográficas, epidemiológicas e sociais, durante o período de fechamento das escolas como medida de controle da covid-19. MÉTODOS Realizou-se um inquérito sorológico em setembro de 2020 com amostra aleatória estratificada por tipo de rede de ensino (pública municipal, pública estadual e privada). Foi coletada amostra de sangue venoso utilizando-se o teste de imunoensaio de fluxo lateral da fabricante Wondfo para detecção de anticorpos totais contra o vírus SARS-CoV-2. Aplicaram-se questionários semiestruturados para o levantamento de dados clínicos, demográficos, sociais e epidemiológicos. RESULTADOS A soroprevalência de anticorpos do vírus SARS-CoV-2 em escolares foi de 16,6% (IC95% 15,4–17,8). O estudo encontrou soroprevalências mais elevadas na rede pública municipal (18,5%; IC95% 16,6–20,6) e estadual (16,2%; IC95% 14,4–18,2) em relação à rede privada (11,7; IC95% 10,0–13,7) e entre escolares da raça/cor preta e parda (18,4%; IC95% 16,8–20,2) e no estrato social mais vulnerável (18,5%; IC95% 16,9–20,2). A pesquisa identificou menores soroprevalências nos escolares que relataram seguir as medidas recomendadas de proteção contra a covid-19. CONCLUSÃO A soroprevalência de anticorpos contra o vírus SARS-CoV-2 atinge principalmente os escolares socialmente mais vulneráveis. Este estudo pode contribuir para embasar políticas públicas que reforcem a importância da suspensão das aulas presenciais e da necessidade de estratégias de medidas de proteção e acompanhamento do status sorológico daqueles que ainda não foram contemplados no calendário vacinal.

ABSTRACT OBJECTIVE To estimate seroprevalence of SARS-CoV-2 antibodies in schoolchildren aged 4 to 14 years living in the city of São Paulo, according to clinical, demographic, epidemiological, and social variables, during the school closure period as a measure against covid-19 spread. METHODS A serological survey was made in September 2020 with a random sample stratified by school system (municipal public, state public and private) type. A venous blood sample was collected using the Wondfo SARS-CoV-2 Antibody Test (lateral flow method) for detection of total SARS-CoV-2 virus antibodies. Semi-structured questionnaires were applied to collect clinical, demographic, social, and epidemiological data. RESULTS Seroprevalence of SARS-CoV-2 antibodies in schoolchildren was of 16.6% (95%CI 15.4–17.8). The study found higher seroprevalence in the municipal (18.5%; 95%CI 16.6–20.6) and state (16.2%; 95%CI 14.4–18.2) public school systems compared to the private school system (11.7; 95%CI 10.0–13.7), among black and brown students (18.4%; 95%CI 16.8–20.2) and in the most vulnerable social stratum (18.5 %;95%CI 16.9–20.2). Lower seroprevalence was identified in schoolchildren who reported following the recommended protective measures against covid-19. CONCLUSION Seroprevalence of SARS-CoV-2 antibodies is found mainly in the most socially vulnerable schoolchildren. This study can contribute to support public policies that reinforce the importance of suspending face-to-face classes and developing strategies aimed at protective measures and monitoring of the serological status of those who have not yet been included in the vaccination schedule.

https://doi.org/10.11606/s1518-8787.2023057004782

Seroprevalence of SARS-CoV-2 antibodies in schoolchildren in the city of São Paulo, 2020
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Kamioka, Gabriela Akemi

; Madalosso, Geraldine

; Albuquerque, José Olimpio Moura de

; Costa, Selma Anequini

; Ferreira, Paula Bisordi

; Sato, Ana Paula Sayuri

; Glasser, Paula Regina

; Pino, Francisco Alberto

; Burihan, Patrícia Carla Piragibe Ramos

; Carvalho, Ana Carolina Aguiar de

; Amorim, Ana Beatriz Pagliaro

; Cavazzana, Cinthya Luzia

; Aires, Caroline Cotrim

; Kataoka, Ana Paula Arruda Geraldes

; Savani, Elisa San Martin Mouriz

; Bessa, Thirsa Alvares Franco

; Aguiar, Breno Souza de

; Failla, Marcelo Antunes

; Santos, Edson Aparecido dos

; Brito, Edjane Maria Torreão

; Santos, Maria Cristina Honório dos

; Caldeira, Luiz Artur Vieira

; Silva, Solange Maria Saboia e

; Zamarco, Luiz Carlos

; Fonseca, Sandra Maria Sabino

; Lima, Marcia Maria de Cerqueira

; Marques, Ivanilda Argenau

; Mauro, Athenê Maria de Marco França

; Masi, Eduardo de

Revista de Saúde Pública

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2023, Volume 57 elocation 6s

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.11606/s1518-8787.2023057004782

Changes in body composition of burn patients during the phases of response to trauma
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Arruda, Andressa Maranhão de

; Gadelha, Patrícia Calado Ferreira Pinheiro

; Soares, Bruna Lúcia de Mendonça

; Dowsley, Catiana Coelho Cabral

; Lemos, Maria da Conceição Chaves de

; Santos, Ana Célia Oliveira dos

Revista Brasileira de Enfermagem

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2023, Volume 76 Nº 6 elocation e20230039

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To assess the changes in body composition of burn patients through electrical bioimpedance in the phases of response to trauma. Methods: a longitudinal observational study, carried out from October 2019 to March 2020. Sociodemographic, clinical, epidemiological, anthropometric and body composition data were collected. Statistical analysis was performed with SPSS, considering a significance of 5%. The comparison between variables was performed using the paired Student’s t test. Results: the sample consisted of 58 adult burn patients, with a mean age of 38.2±12.5 years. The mean body surface area (BSA) with burns was 10.8±7.3%. Nutritional assessment demonstrated a depletion of body weight, Body Mass Index, fat-free mass and muscle mass in the phases of response to trauma (p<0.005). Conclusion: metabolic alterations in the different phases of the metabolic response to trauma led to a depletion of the nutritional status of burn patients of both sexes during hospitalization.

RESUMEN Objetivo: evaluar alteraciones en la composición corporal de pacientes quemados mediante bioimpedancia eléctrica en las fases de respuesta al trauma. Métodos: estudio observacional longitudinal, realizado de octubre de 2019 a marzo de 2020. Se recogieron datos sociodemográficos, clínicos, epidemiológicos, antropométricos y de composición corporal. El análisis estadístico se realizó mediante SPSS, considerando una significancia del 5%. La comparación entre variables se realizó mediante la prueba de la t de Student pareada. Resultados: la muestra estuvo compuesta por 58 pacientes adultos quemados, con una edad media de 38,2±12,5 años. El área de superficie corporal media (ASC) con quemaduras fue de 10,8±7,3%. La evaluación nutricional mostró disminución del peso corporal, índice de masa corporal, masa magra y masa muscular en las fases de respuesta al trauma (p<0,005). Conclusión: los cambios metabólicos en las diferentes fases de la respuesta metabólica al trauma llevaron a la disminución del estado nutricional de los pacientes quemados de ambos sexos durante la hospitalización.

RESUMO Objetivo: avaliar as alterações na composição corporal de pacientes queimados por meio da bioimpedância elétrica nas fases de resposta ao trauma. Métodos: estudo observacional longitudinal, realizado de outubro de 2019 a março de 2020. Foram coletados dados sociodemográficos, clínicos, epidemiológicos, antropométricos e de composição corporal. A análise estatística foi realizada com o SPSS, considerando significância de 5%. Comparação entre as variáveis foi realizada por meio do teste t de Student pareado. Resultados: a amostra foi composta por 58 pacientes adultos queimados, com média de 38,2±12,5 anos. A média da área de superfície corporal (ASC) com queimaduras foi de 10,8±7,3%. A avaliação nutricional demonstrou depleção do peso corporal, índice de massa corporal, massa magra e massa muscular nas fases de resposta ao trauma (p<0,005). Conclusão: alterações metabólicas nas diferentes fases da resposta metabólica ao trauma levaram a depleção do estado nutricional de pacientes queimados de ambos os sexos durante a internação.

https://doi.org/10.1590/0034-7167-2023-0039

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

INFLUENCES OF THE AFFECTIVE-RELATIONAL SPHERE WITH PARTNERS ON ADOLESCENTS’ INTENDED PREGNANCY
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Silva, Ana Maria Nunes da

; Corrêa, Áurea Christina de Paula

; Mandú, Edir Nei Teixeira

; Gaíva, Maria Aparecida Munhoz

; Teston, Elen Ferraz

; Vieira, Viviane Cazetta de Lima

; Dalprá, Luanna de Arruda e Silva

; Marcon, Sonia Silva

Texto & Contexto - Enfermagem

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2023, Volume 32 elocation e20230109

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to understand interconnected influences on adolescents’ intended pregnancy based on particularities of the affective-relational sphere with partners. Method: this is a qualitative-interpretive study, carried out with 16 pregnant adolescents living in a neighborhood with a low socioeconomic level in a capital in the center-west of Brazil. Data were collected in 2019 through in-depth interviews, with complementary use of self-portrait, relational map and photo-elicitation resources, subjected to thematic content analysis. Results: adolescents’ intention-action towards becoming pregnant was based on status assessment and romantic relationship quality with their partners in terms of marriage/union, bond-commitment, partnership-financial protection and good interaction-love. They expressed needs for emotional bonding and material security, psychological particularities of their stage of development, in addition to social representations built on the conjugal and loving relationship and being a man and a woman in the family. Connectedly, it reflected on social conditions and family relationships experienced as well as absorptions of the cultural ideal of romantic and gender love. Conclusion: in adolescents’ reproductive health, it is essential to consider the affective influences on being pregnant, without detaching them from their social and family insertions as well as their ways of exercising agency over their affective-sexual trajectories.

RESUMEN Objetivo: comprender influencias interconectadas sobre la intención de embarazo de adolescentes a partir de particularidades del ámbito afectivo-relacional con la pareja. Método: se trata de un estudio cualitativo-interpretativo, realizado con 16 adolescentes embarazadas que viven en un barrio de bajo nivel socioeconómico, en una capital del centro-oeste de Brasil. Los datos fueron recolectados en 2019 a través de entrevistas en profundidad, con uso complementario de recursos de autorretrato, mapa relacional y fotoecitación, sometidos a análisis de contenido temático. Resultados: la intención-acción de las adolescentes para quedar embarazada se basó en la evaluación del estado y la calidad de la relación sentimental con sus parejas en términos de matrimonio/unión, vínculo-compromiso, sociedad-protección financiera y buena interacción-amor. Estos expresaron necesidades de vinculación afectiva y seguridad material que vivieron, particularidades psíquicas de su etapa de desarrollo, además de representaciones sociales construidas sobre la relación conyugal, amorosa y el ser hombre y mujer en la familia. De manera relacionada, reflexionaron sobre las condiciones sociales y las relaciones familiares vividas, así como sobre la absorción del ideal cultural del amor romántico y de género. Conclusión: en la salud reproductiva de las adolescentes, es fundamental considerar las influencias afectivas sobre el embarazo, sin desvincularlas de sus inserciones sociales y familiares, así como de sus formas de ejercer la agencia en sus trayectorias afectivo-sexuales.

RESUMO Objetivo: compreender influências interconexas no engravidar intencionado de adolescentes a partir de particularidades da esfera afetivo-relacional com o parceiro. Método: estudo qualitativo-interpretativo, realizado com 16 adolescentes grávidas residentes em um bairro de baixo nível socioeconômico, em uma capital do centro-oeste brasileiro. Os dados foram coletados em 2019 mediante entrevistas em profundidade, com uso complementar dos recursos autorretrato, mapa relacional e foto-elicitação, submetidos à Análise de Conteúdo Temática. Resultados: a intenção-ação das adolescentes voltada ao engravidar sustentou-se na apreciação do status e da qualidade da relação amorosa com o parceiro quanto aos aspectos casamento/união, vínculo-compromisso, parceria-proteção financeira e boa interação-amor. Estas exprimiram necessidades de vínculo afetivo e de segurança material por elas vividas, particularidades psíquicas da sua fase de desenvolvimento, além de representações sociais construídas sobre a relação conjugal, amorosa e do ser homem e mulher na família. De forma conexa refletiram sobre condições sociais e relações em família vividas, além de absorções do ideal cultural do amor romântico e de gênero. Conclusão: na saúde reprodutiva de adolescentes, é indispensável considerar as influências afetivas no engravidar, sem descolá-las das inserções sociais e em família daquelas, bem como dos seus modos de exercer a agência de suas trajetórias afetivo-sexuais.

https://doi.org/10.1590/1980-265x-tce-2023-0109en

Chronic endometritis and assisted reproduction: a systematic review and meta-analysis reproduction metaanalysis meta analysis
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Veiga, Eduardo Carvalho de Arruda

; Soares Junior, Jose Maria

; Samama, Marise

; Ikeda, Fabio

; Francisco, Luciana Semião

; Sartor, Amanda

; Urbanetz, Lorena Ana Mercedes Lara

; Baracat, Edmund Chada

; Ueno, Joji

Revista da Associação Médica Brasileira

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2023, Volume 69 Nº 10 elocation e20230792

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1806-9282.20230792

Brazilians’ level of knowledge, attitudes and practices towards COVID-19: a cross-sectional study
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Gardona, Rodrigo Galvão Bueno

; da Silva, José Vitor

; Arruda, Gisele

; Damin, Silvana

; Abdala, Edson

; Lima, Christiana Almeida Salvador

; Vasconcellos, Leonardo de Souza

; Queiroz, Wladimir

; Zandonái, Alini Cristini

; Danielsk, Ailla Mazon

; Villar de Sena, Ana Carolina

; Cattani, Álvaro Cesar

; Bringhentti, Amanda

; Denardi, Angélica

; Alérico, Ana Lígia Scotti

; Fergutz, Gabriella

; Ribas, Izabela de Oliveira

; Spricigo, Laura Maria Voss

; Gandolfo, Lara

; Correa, Liamara

; Bordignon, Jardel Cristiano

; de Oliveira, Juliana Girotto

; Stefanel, Michel Pandolfo

; Reis, Beatriz Castro

; de Campos, Vilson Geraldo

; Ortigoso, Danilo

; Figueiredo, Gerusa Maria

Sao Paulo Medical Journal

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Jun 2022, Volume 140 Nº 3 Páginas 331 - 340

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Brazil is facing increasing cycles of numbers of infected people and deaths resulting from coronavirus disease 2019 (COVID-19). This situation involves a series of factors, including the behavior of the population, that can be decisive for controlling the disease. OBJECTIVE: To determine the knowledge, attitudes and practices of the Brazilian population regarding COVID-19. DESIGN AND SETTING: Cross-sectional survey-type study, conducted using a population sample from different Brazilian states. METHODS: A quantitative, descriptive and analytical approach was used. Sampling was done according to convenience and via snowballing. The data collection instrument was a knowledge, attitudes and practices system. RESULTS: 1,655 people from all over Brazil participated in the survey; 80% were living in the southern region and 70.15% were female. More than 90% had knowledge and good attitudes relating to the means of transmission, preventive care and symptoms associated with COVID-19, although their knowledge and attitudes were not fully reflected in daily practices, for which there was lower adherence (80%). Greater knowledge was correlated with older participants, larger number of children, female sex and marital status; better attitude, with female sex and complete higher education; and better practices, with greater age, larger number of children and female sex. CONCLUSION: A large part of the population has general knowledge about COVID-19, but not all knowledge was applied in practice. Older people, females and university graduates stood out as the best informed and most committed to controlling the disease.

https://doi.org/10.1590/1516-3180.2021.0541.23072021

ALDH1 expression and potential clinical implications in chronic inflammatory periapical lesions
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Farias, Zilda Betânia Barbosa Medeiros de

; Silva, Leorik Pereira da

; de Arruda, José Alcides Almeida

; Cavalcante, Jade de Souza

; Almeida, Híttalo Carlos Rodrigues de

; Oliveira, Maria Cristina Valença de

; Souza, Lélia Batista de

; Sobral, Ana Paula Veras

Brazilian Oral Research

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2022, Volume 36 elocation e019

Resumo: En | Texto: En | PDF: En

Abstract: Aldehyde dehydrogenase 1 (ALDH-1) is a marker of stem cells in a variety of diseases, but its role in individuals with chronic inflammatory periapical lesions remains unknown. The aim of this study was to investigate the presence of cells with a stem cell profile based on the immunoexpression of ALDH-1 in periapical granulomas (PGs) and radicular cysts (RCs). A total of 51 cases of periapical lesions (25 PGs and 26 RCs) were subjected to immunohistochemical study. The anti-ALDH-1 antibody was applied using the immunoperoxidase technique. An immunoexpression score (intensity vs. percentage of cells) was used, with the cases being classified as low expression (score: 0 to 4) and high expression (score: 6 to 9). The Chi-square test was used with a 5% level of significance. Immunoexpression of ALDH-1 was detected in all cases of PGs and RCs. In PG cases, the expression was diffuse in connective tissue cells, with most cases exhibiting high expression (n = 18; 69.2%), while in RC cases the expression revealed focal distribution in cells of the capsule and epithelial cells of the cystic lining, with most cases classified as low expression (n = 18; 72%). Significant differences in the expression scores of ALDH-1 were observed in PGs (p = 0.003). The variable expression of ALDH-1 suggests the presence of cells with stem cell profiles in PGs and RCs. These findings suggest that periapical tissues infiltrated by chronic inflammation can recruit important cells for the repair or evolution of periapical lesions.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0019

Evaluation of the rheological effect of asphalt binder modification using Linum usitatissimum oil
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Silva, Conrado Cesar Vitorino Pereira da

; Melo Neto, Osires de Medeiros

; Rodrigues, John Kennedy Guedes

; Mendonça, Ana Maria Gonçalves Duarte

; Arruda, Sonaly Mendes

; Lima, Robson Kel Batista de

Matéria (Rio de Janeiro)

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2022, Volume 27 Nº 3 elocation e20220138

Resumo: En | Texto: En | PDF: En

ABSTRACT Warm mixtures are an essential alternative for paving as they minimize costs and environmental impacts, and their performance is similar to hot mixtures. This research evaluated the effect of adding linseed oil obtained from Linum usitatissimum in the contents of 1, 2, 3, 4, 5, and 6% by weight on the physical and rheological properties of the asphalt binder. The asphalt binder was evaluated through tests of penetration, softening point, rotational viscosity, performance grade (PG); these tests were performed before and after the short-term aging procedure; multiple stress creep and recovery (MSCR), and linear amplitude sweep (LAS). It has been verified that the mixing temperature could be reduced by up to 15 °C for the 6% linseed oil content, but it was lost in terms of performance, level of supported traffic, and fatigue life. In the so-called ideal content found, 4% linseed oil, there is a reduction in the mixing temperature of around 10 °C, as well as a maximum temperature of PG, 58 °C, it reduces by only one step compared to the pure binder, 64 °C, in addition to presenting the second-longest fatigue life of the grades studied, being classified as ideal for standard traffic by the MSCR test. Linseed oil proved to be an excellent green alternative for the production of warm mixtures.

https://doi.org/10.1590/1517-7076-rmat-2022-0138

10.

Application of PGF2α at the moment of fixed-time artificial insemination in crossbred beef cows
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Marques, Jéssica Cristina dos Santos

; Cadima, Gustavo Pereira

; Faria, Ana Cláudia Fagundes

; Guimarães, Eduarda Arruda

; Oliveira, Fabiana Silva

; Santos, Ricarda Maria dos

Animal Reproduction

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2022, Volume 19 Nº 4 elocation e20220012

Resumo: En | Texto: En | PDF: En

Abstract Although studies have shown positive effects of gonadotropin releasing hormone (GnRH) or prostaglandin F2α (PGF2α) at the moment of fixed-time artificial insemination (FTAI) in the conception rate (CR) of cattle, its effects on treatments based on progesterone (P4) and estradiol benzoate (EB) is still not conclusive. The objective of this study was (1) to evaluate the effect of a PGF2α analogue at FTAI in the CR of crossbred beef cows submitted to a 11d FTAI protocol based on P4 and EB; and (2) to describe the CR between PGF2α-treated and control cows in different body condition scores (BCS) and parity categories. Crossbred (½ Nellore and ½ Angus) beef cows were submitted to a synchronization protocol and randomly assigned into 2 groups: Control (n = 163), at FTAI cows received 2 mL of saline solution as a placebo, and PGF2α (n = 163), at FTAI cows were treated with PGF2α analogue (10 mg of dinoprost tromethamine). Pregnancy diagnosis was performed 33d post-FTAI. Binary logistic regression model was used to analyze the effect of PGF2α treatment on CR. There was no difference in CR between PGF2α and control groups (P > 0.05; odds ratio (OR) = 0.92; confidence interval (CI) = 0.59-1.4). A greater CR was found in heifers (P = 0.0006, OR = 2.65, CI = 1.61 - 4.38) and multiparous (P = 0.0006, OR = 2.12, CI = 1.04 - 4.3) when compared to primiparous cows. Cows with low BCS (4; 9-point scale) showed lower CR when compared with moderate BCS (5-6; 9-point scale) (P < 0.05; OR = 0.10; CI = 0.06 - 0.18). There was no numerical difference on CR between PGF2α-treated and control cows in different BCS and parity categories. The results suggested that the CR in this study was not influenced by 10 mg PGF2α analogue at FTAI.

https://doi.org/10.1590/1984-3143-ar2022-0012

11.

Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring
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Gomes, Ellen Carolina Zawoski

; Teleken, Jakeline Liara

; Vargas, Rodrigo

; Alegre-Maller, Ana Claudia Paiva

; Amorim, João Paulo de Arruda

; Bonfleur, Maria Lúcia

; Balbo, Sandra Lucinei

einstein (São Paulo)

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2022, Volume 20 elocation eAO6778

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To investigate the effect of pre and postnatal exposure to a glyphosate-based herbicide on glucose metabolism and liver histology in adult F1 mice offspring. Methods: Female mice (C57Bl/6) received 0.5% of glyphosate (Roundup Original DI®) in drinking water or purified water (Glyphosate Group and Control Group respectively) during pregnancy and lactation. Offspring (F1) were submitted to glucose and insulin tolerance tests and euthanized on postnatal day 150. Body and plasma parameters, and liver histology were analyzed. Results: Exposure to glyphosate reduced maternal body weight gain during pregnancy and lactation, with no impacts on litter size. Pre and postnatal exposure to glyphosate did not affect body parameters but increased glucose tolerance on postnatal day 60. In spite of glucose tolerance normalization by postnatal day 143, this effect was associated with higher insulin sensitivity relative to mice in the Control-F1 Group. Mice in the Glyphosate-F1 Group had mild and moderate lobular inflammation in the liver. Conclusion: Maternal exposure to glyphosate affected insulin sensitivity and caused hepatic inflammation in adult F1 mice offspring.

https://doi.org/10.31744/einstein_journal/2022ao6778

12.

How people affected by Chagas disease have struggled with their negligence: history, associative movement and World Chagas Disease Day
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de Oliveira Junior, Wilson Alves

; Gómez i Prat, Jordi

; Albajar-Viñas, Pedro

; Carrazzone, Cristina

; Kropf, Simone Petraglia

; Dehousse, Aurore

; Camargo, Ana Maria de Arruda

; Anselmi, Mariella

; Barba, Maria Cristina Parada

; Guiu, Isabel Claveria

; Barros, Maria das Neves Dantas Silveira

; Cavalvanti, Maria da Glória Melo

; Correia, Cassandra Barros

; Martins, Silvia Marinho

; FINDECHAGAS Workgroup,

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220066

Resumo: En | Texto: En | PDF: En

It is well documented that Chagas disease (CD) can pose a public health problem to countries. As one of the World Health Organization Neglected Tropical Diseases undoubtedly calls for comprehensive healthcare, transcending a restricted biomedical approach. After more than a century since their discovery, in 1909, people affected by CD are still frequently marginalised and/or neglected. The aim of this article is to tell the story of their activism, highlighting key historical experiences and successful initiatives, from 1909 to 2019. The first association was created in 1987, in the city of Recife, Brazil. So far, thirty associations have been reported on five continents. They were created as independent non-profit civil society organisations and run democratically by affected people. Among the common associations’ objectives, we notably find: increase the visibility of the affected; make their voice heard; build bridges between patients, health system professionals, public health officials, policy makers and the academic and scientific communities. The International Federation of Associations of People Affected by CD - FINDECHAGAS, created in 2010 with the input of the Americas, Europe and the Western Pacific, counts as one of the main responses to the globalisation of CD. Despite all the obstacles and difficulties encountered, the Federation has thrived, grown, and matured. As a result of this mobilisation along with the support of many national and international partners, in May 2019 the 72nd World Health Assembly decided to establish World Chagas Disease Day, on 14 April. The associative movement has increased the understanding of the challenges related to the disease and breaks the silence around Chagas disease, improving surveillance, and sustaining engagement towards the United Nations 2030 agenda.

https://doi.org/10.1590/0074-02760220066

13.

Visceral adiposity indicators and cardiovascular risk in hemodialytic patients
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Melo, Dejane de Almeida

; Santos, Alcione Miranda dos

; Furtado, Elane Viana Hortegal

; França, Ana Karina Teixeira

; Santos, Elisângela Milhomem dos

; Arruda, Ilma Kruze Grande de

; Carvalho, Tuane Rodrigues de

; Pinho, Claudia Porto Sabino

; Diniz, Alcides da Silva

; Lemos, Maria da Conceição Chaves de

Archives of Endocrinology and Metabolism

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Dez 2021, Volume 65 Nº 6 Páginas 811 - 820

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Cardiovascular diseases represent the main cause of death in chronic kidney disease (CKD). We aimed to evaluate the prevalence and association of the hypertriglyceridemia-waist phenotype (HWP) and visceral adiposity index (VAI) with cardiometabolic risk factors (CR) in patients with CKD on hemodialysis (HD). Materials and methods: The study is based on a cross-sectional design with 265 HD patients in two cities in northeastern Brazil. The VAI was calculated considering the variables body mass index (BMI), waist circumference (WC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-c). HWP was defined as the concomitant elevation of WC and TG. The Poisson Regression Model with robust variance estimation was adjusted considering a hierarchical approach for explanatory variables. Prevalence ratios (PR) were also estimated. The level of significance adopted was 5%. Results: In our study HWP and VAI prevalence’s were 29.82% and 58.49%, respectively. In the final model, there was an association between VAI and female gender (PR = 1.46; p < 0.0001) and high body fat (% BF) (PR = 1.33; p < 0.0019). HWP was associated with females (PR = 1.80; p = 0.002), alcohol consumption (PR = 1.58; p = 0.033), obesity (PR = 1.89; p = 0.0001), high %BF (PR = 1.76; p = 0.012) and reduced HDL-c (PR = 1.48; p = 0.035). Conclusion: The HWP stood out as the association with more CR factors, representing a promising method for tracking cardiometabolic risk in HD patients, mainly female.

https://doi.org/10.20945/2359-3997000000421 2 downloads

14.

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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Out 2021, Volume 117 Nº 4 Páginas 782 - 844

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

15.

Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021
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Izar, Maria Cristina de Oliveira

; Lottenberg, Ana Maria

; Giraldez, Viviane Zorzanelli Rocha

; Santos Filho, Raul Dias dos

; Machado, Roberta Marcondes

; Bertolami, Adriana

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Faludi, André Arpad

; Moreira, Annie Seixas Bello

; Geloneze, Bruno

; Magnoni, Carlos Daniel

; Scherr, Carlos

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper Corrêa

; Nakandakare, Edna Regina

; Fonseca, Francisco Antonio Helfenstein

; Mota, Isabela Cardoso Pimentel

; Santos, José Ernesto dos

; Kato, Juliana Tieko

; Beda, Lis Mie Masuzawa

; Vieira, Lis Proença

; Bertolami, Marcelo Chiara

; Rogero, Marcelo Macedo

; Lavrador, Maria Silvia Ferrari

; Nakasato, Miyoko

; Damasceno, Nagila Raquel Teixeira

; Alves, Renato Jorge

; Roberta Soares, Lara

; Costa, Rosana Perim

; Machado, Valéria Arruda

Arquivos Brasileiros de Cardiologia

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Jan 2021, Volume 116 Nº 1 Páginas 160 - 212

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201340 9969 downloads

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