Pesquisa | SciELO

RESUMO Embora a região semiárida do Nordeste brasileiro seja uma grande produtora de maracujá amarelo, os problemas de sais no solo e nas fontes hídricas, em muitas áreas, têm limitado o crescimento e a produção dessa cultura, o que realça a importância de estudos visando a reduzir tais efeitos. Nesse contexto, objetivou-se com este estudo, avaliar o efeito da aplicação foliar de piruvato, como mitigador do estresse salino, sobre a morfofisiologia do maracujazeiro cv. Redondo Amarelo, em fase de mudas. Os tratamentos constaram de três condutividades elétricas da água de irrigação (CEa: 0,8, 2,4 e 4,0 dS m-1) e três concentrações de piruvato (0, 25 e 50 mM), distribuídos em delineamento experimental de blocos casualizados, em esquema fatorial 3 × 3, com quatro repetições e duas plantas por parcela. A irrigação com águas de CEa de 4,0 dS m-1 reduz as variáveis de crescimento, fitomassa, indice de qualidade de Dickson e aumenta o extravasamento de eletrólitos em mudas de maracujazeiro cv. Redondo Amarelo. A aplicação exógena de piruvato de cálcio (25 e 50 mM) favorece as variáveis de crescimento, fitomassa, indice de qualidade de Dickson, teor relativo de água, suculência foliar e reduz o extravasamento de eletrólitos no limbo foliar do maracujá. A aplicação exógena de piruvato atenua o estresse salino, com efeitos benéficos na taxa de assimilação de CO2, transpiração, eficiência da carboxilação instantânea, eficiência intrínseca do uso da água e massa seca das raízes.

ABSTRACT Although the semi-arid region of Northeast Brazil is a major producer of yellow passion fruit, the problems of salts in the soil and water sources, in many areas have limited the growth and production of this crop, which highlights the importance of studies aimed at reducing such effects. In this context, the objective of this study was to evaluate the effect of foliar application of pyruvate, as a mitigator of salt stress, on the morphophysiology of yellow passion fruit, in seedling phase. The treatments consisted of three electrical conductivities of irrigation water (ECw: 0.8, 2.4, and 4.0 dS m-1) and three concentrations of pyruvate (0, 25, and 50 mM), distributed in a randomized block experimental design in a 3 × 3 factorial scheme, with four replications and two plants per plot. Irrigation with ECw of 4.0 dS m-1 reduces growth variables, phytomass, Dickson quality index, and increases electrolyte leakage in passion fruit seedlings cv. Redondo Amarelo. Exogenous application of calcium pyruvate (25 and 50 mM) increased growth, phytomass, Dickson quality index, relative water content and leaf succulence and reduced electrolyte leakage in the leaf blade in passion fruit. Exogenous application of pyruvate attenuates salt stress, with beneficial effects on CO2 assimilation rate, transpiration, instantaneous carboxylation efficiency, intrinsic water use efficiency, and root dry mass.

https://doi.org/10.1590/1807-1929/agriambi.v26n11p763-770

Granuloma annulare and necrobiosis lipoidica in a patient with HNF1A-MODY
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Brandes, Gabriela Irene Garcia

; Peixoto-Barbosa, Renata

; Meski, Ana Paula Gomes

; Giuffrida, Fernando M. A.

; Reis, André F.

Archives of Endocrinology and Metabolism

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Jun 2022, Volume 66 Nº 3 Páginas 420 - 424

Resumo: En | Texto: En | PDF: En

SUMMARY Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic forms of diabetes mellitus with distinct clinical features. Clinical dermatological phenotypes in MODY patients are very rare in literature. This report describes a patient with HNF1A-MODY presenting with necrobiosis lipoidica (NL) and granuloma annulare (GA). A 39-year-old asymptomatic woman, with atypical diabetes diagnosed at age 17, has a confirmed HNF1A mutation on exon 2 (c.392G>A, p.R131Q), classified as Pathogenic by the ACMG guidelines. She has reasonable metabolic control using oral anti-diabetic medications and has no chronic diabetic complications. Clinical and histologic diagnoses of both NL and GA were made. We discuss these conditions and their association with MODY.

https://doi.org/10.20945/2359-3997000000477

The contribution of the BIOTA/FAPESP Program to the advancement of the knowledge on terrestrial invertebrates
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Noll, Fernando B.

; Barbosa, Marina F. de C.

; Santos, Eduardo F.

; Castilho, Raphael de C.

; Lamas, Carlos J.E.

; Freitas, André V.L.

; de Moraes, Gilberto J.

Biota Neotropica

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2022, Volume 22 Nº spe elocation e20221398

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A variabilidade dos organismos em uma determinada área constitui o que se denomina biodiversidade, uma das propriedades fundamentais da natureza, responsável pelo equilíbrio e estabilidade dos ecossistemas. A perda da biodiversidade tem sido uma grande preocupação para os cientistas, principalmente pelo papel desempenhado pelas atividades humanas, com potencial para desencadear circunstâncias irreversíveis. A Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) desempenha um papel importante no apoio às pesquisas nos mais diversos ramos da ciência. No final da década de 1990, a FAPESP lançou um grande programa de fomento à pesquisa em biodiversidade, denominado BIOTA/FAPESP. Até o momento, este programa financiou a realização de 26 projetos, envolvendo atividades na maior parte do Brasil, embora tenham como foco principal o estado de São Paulo. Esses projetos geraram cerca de 1.140 publicações em periódicos de alto impacto, fornecendo informações relevantes que incluem a descrição original de 1.187 espécies e 76 gêneros e a descrição complementar de 350 espécies, além de diversos trabalhos de inventário, estudos biológicos etc. O programa também tem sido fundamental para o estabelecimento ou adequação de instalações de pesquisa científica e o treinamento de novos taxonomistas. Os grupos de invertebrados terrestres mais estudados incluem os Insecta das ordens Hymenoptera, Lepidoptera e Diptera, e os Arachnida das subclasses Araneae e Acari. Projetos distintos também têm contribuído para a detecção de organismos potencialmente úteis como agentes de controle biológico e na determinação de mapas de áreas preferenciais para o estabelecimento de políticas públicas. No futuro, os grupos prioritários de estudo devem incluir os Annelida e os Nematoda, pelo potencial que ambos têm como organismos benéficos, ou pelo potencial que alguns Nematoda têm como organismos prejudiciais a plantas e animais.

Abstract The variability of the organisms living in a given area constitute what is referred to as biodiversity, one of nature’s fundamental properties, responsible for the balance and stability of ecosystems. The loss of biodiversity has been of great concern to scientists, especially because of the role played by human activities in this regard, able to lead to irreversible circumstances. The São Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP) plays a major role in supporting research efforts in the most diverse branches of science. In the late 1990´s, FAPESP launched a major program to promote research on biodiversity, named BIOTA/FAPESP. So far, this program has financed the conduction of 26 projects, involving research activities in most of Brazil, while focusing mainly the State of São Paulo. These projects have generated about 1140 publications in peer-reviewed journals of high standard, providing relevant information, including the original description of 1187 species and 76 genera, the complementary description of 350 species, as well as a number of inventory works, biological studies, etc. The program has also been instrumental in the establishment or adequacy of research facilities and training of new taxonomists. Most extensively studied groups of terrestrial invertebrates include Insecta of the orders Hymenoptera, Lepidoptera and Diptera, and Arachnida of the subclasses Araneae and Acari. Distinct projects have also contributed to the detection of organisms potentially useful as biological control agents and in the determination of maps of major interest for the establishment of public policies. In the future, priority groups for study should include the Annelida and the Nematoda, for the potential both have as beneficial organisms, or for the potential some Nematoda have as organisms harmful to plants and animals.

https://doi.org/10.1590/1676-0611-bn-2022-1398

Natural history museums and zoological collections of São Paulo State
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Percequillo, Alexandre Reis

; Barbosa, Marina F. C.

; Bockmann, Flávio A.

; Bogoni, Juliano A.

; Esguícero, André L. H.

; Lamas, Carlos

; Moraes, Gilberto José de

; Pinto-da-Rocha, Ricardo

; Silveira, Luís Fábio

Biota Neotropica

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2022, Volume 22 Nº spe elocation e20221426

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Scientific collections constitute a valuable source for contributions to scientific research and the training of human resources in systematics, but also other areas of biological knowledge. In this contribution, we intend to discuss these advancements in collections and the role played by FAPESP in sponsoring them, as well as a general overview of the zoological collections in São Paulo state. We also aim to stress the importance of zoological collections and the need for continuous logistic and financial support from institutions and research agencies to maintain and develop these unique repositories of biodiversity. From 1980 to the present, FAPESP supported 118 research projects focused on several areas of zoology that are directly or indirectly associated with collections. There is a constant growth in the number of projects, and the financial support provided by FAPESP through the Biota Program was paramount for the advancement of our knowledge of biodiversity in Brazil. Parallel to the scientific advances, but not less important, this support allowed curators to increase the number of specimens, and to organize, maintain and digitize them in these valuable and irreplaceable collections. Regarding the lack of new taxonomists, it is essential that FAPESP and universities in São Paulo encourage the formation of new academics in zoological groups where specialists are rare. Considering the investment provided by FAPESP, it is quite important that the institutions that benefited from these resources took greater responsibility to safeguard these collections, and they should consider including resources on their budgets to obtain safety certificates, ensuring their permanence for many generations to come. Zoological collections are a heritage of humanity and are essential not only for the improvement of our knowledge of biodiversity but also with direct applications, among other services provided by these biological resources. It is important that research and teaching institutions in São Paulo that house specimens under their care start to value more this important patrimony and this heritage, as these collections represent the most valuable testimony of our impressive biodiversity, records of our past, and windows to our future, essential to our academic, scientific, cultural and social sovereignty.

Resumo As coleções científicas constituem uma fonte valiosa para contribuições à pesquisa científica e para a formação de recursos humanos em sistemática, mas também em outras áreas do conhecimento biológico. Nesta contribuição, pretendemos discutir esses avanços nas coleções e o papel desempenhado pela FAPESP no seu patrocínio, bem como um panorama geral das coleções zoológicas do estado de São Paulo. Também pretendemos enfatizar a importância das coleções zoológicas e a necessidade de apoio logístico e financeiro contínuo de instituições e agências de pesquisa para manter e desenvolver esses repositórios únicos de biodiversidade. Ao longo de 1980 até os dias atuais, a FAPESP apoiou 118 projetos de pesquisa focados em diversas áreas da zoologia, direta ou indiretamente associados a coleções. Há um crescimento constante no número de projetos, e o apoio financeiro da FAPESP por meio do Programa Biota foi fundamental para o avanço do nosso conhecimento sobre a biodiversidade no Brasil. Paralelamente aos avanços científicos, mas não menos importante, este apoio permitiu aos curadores aumentar o número de exemplares, e organizá-los, mantê-los e digitalizá-los nestas valiosas e insubstituíveis coleções. Em relação à falta de novos taxonomistas, é fundamental que a FAPESP e as universidades paulistas estimulem a formação de novos acadêmicos em grupos zoológicos onde os especialistas são raros. Considerando o investimento realizado pela FAPESP, é de suma importância que as instituições beneficiadas com esses recursos tenham maior responsabilidade na salvaguarda desses acervos, devendo considerar a inclusão de recursos em seus orçamentos para obtenção de certificados de segurança, garantindo sua permanência por muitas gerações. As coleções zoológicas são patrimônio da humanidade, e são essenciais não apenas para o aprimoramento do nosso conhecimento sobre a biodiversidade, mas também com aplicações diretas, entre outros serviços prestados por esses recursos biológicos. É importante que as instituições de pesquisa e ensino paulistas que abrigam exemplares sob seus cuidados passem a valorizar mais esse importante patrimônio e essa herança, pois essas coleções representam o testemunho mais valioso de nossa impressionante biodiversidade, registros do nosso passado e janelas para o nosso futuro, essenciais à nossa soberania acadêmica, científica, cultural e social.

https://doi.org/10.1590/1676-0611-bn-2022-1426

Biodegradation of the Polycyclic Aromatic Hydrocarbon Fluoranthene by Fungi Strains from a Brazilian Tropical Peat
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Garcia, Anuska C. F. S.

; Birolli, Willian G.

; Araújo, Bruno R.

; Marques, Carla G.

; Barbosa-Junior, Antônio M.

; Diniz, Leandro E. C.

; Porto, André L. M.

; Romão, Luciane P. C.

Journal of the Brazilian Chemical Society

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Set 2021, Volume 32 Nº 9 Páginas 1874 - 1883

Resumo: En | Texto: En | PDF: En

Polycyclic aromatic hydrocarbons (PAHs) are an important environmental issue and the identification of new biocatalysts for an efficient biodegradation of these compounds is essential for bioremediation. Therefore, fungi strains isolated for the first time from a tropical peat at Santo Amaro das Brotas (Brazil) were studied for fluoranthene biodegradation. Fusarium sp. AC-7, Penicillium sp. AC-1 and Penicillium sp. AC-6 were isolated using fluoranthene as sole carbon source. All strains were tested for biodegradation of 100 mg L−1 fluoranthene during 14 and 28 days. After 28 days of biodegradation, 64 ± 3, 60 ± 4 and 51 ± 2% biodegradation was observed for Penicillium sp. AC-1, Penicillium sp. AC-6 and Fusarium sp. AC-7, respectively. Analysis of the obtained compounds enabled the identification of four metabolites, which were common to the three employed strains: anthrone, anthraquinone, 9-methoxyanthracene and cyclopropa[1]phenanthrene. It is important to note that control experiments were performed. The obtained results clearly demonstrated the efficiency of tropical peat fungi in the transformation of fluoranthene. These findings showed the potential of tropical peats for isolation of fungi and indicated that these strains can be applied for bioremediation processes of areas contaminated with fluoranthene and other PAHs.

https://doi.org/10.21577/0103-5053.20210078 48 downloads

Antileishmanial Acetylene Fatty Acid and Acetogenins from Seeds of Porcelia macrocarpa
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Brito, Ivanildo A.

; Oliveira, Emerson A.

; Chaves, Mariana H.

; Thevenard, Fernanda

; Rodrigues-Oliveira, André F.

; Barbosa-Reis, Gustavo

; Sartorelli, Patricia

; Oliveira-Silva, Diogo

; Tempone, Andre G.

; Costa-Silva, Thais A.

; Lago, João Henrique G.

Journal of the Brazilian Chemical Society

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Fev 2021, Volume 32 Nº 2 Páginas 447 - 453

Resumo: En | Texto: En | PDF: En

In the present work five acetylene derivatives (1-5), including three unknowns (1, 3 and 4), were isolated from seeds of Porcelia macrocarpa (Annonaceae). The structures of isolated compounds were determined as docos-13-yn-21-enoic acid (1), 3-hydroxy-4-methylene-2-(eicos-11’-yn-19’-enyl)but-2-enolide (2), 3-hydroxy-4-methylene-2-(octadec-9’-yn-17’-enyl)but-2-enolide (3), 3-hydroxy-4-methylene-2-(hexadec-7’-yn-15’-enyl)but-2-enolide (4), and (2S,3R,4R)-3-hydroxy-4-methyl-2-(eicos-11’-yn-19’-enyl)butanolide (5) by analysis of nuclear magnetic resonance (NMR) and electrospray ionization high-resolution mass spectrometry (ESI-HRMS) data. Moreover, all isolated compounds demonstrated selectivity towards intracellular amastigotes of Leishmania (L.) infantum, especially 2-4 with 50% inhibitory concentration (IC50) values of 9.2, 10.4 and 11.0 µM, respectively, indicating superior activity of that determined to positive control miltefosine (IC50 of 17.8 µM). Furthermore, these compounds showed higher selectivity index (SI) in comparison with miltefosine. Since related acetylene fatty acid 1 displayed reduced antiparasitic potential (IC50 of 48.5 µM), the obtained results suggested that the γ-lactone plays an important role in the antileishmanial activity. However, 2-4 exhibited cytotoxicity to mammalian NCTC cells (CC50 ca. 80 µM), which could be a result of the presence of a conjugated carbonyl system in the lactone ring, since 5, the only acetogenin that presents the saturated ring, lacked mammalian cytotoxicity (CC50 > 200 µM).

https://doi.org/10.21577/0103-5053.20200197 231 downloads

Multiresidue Determination of Endocrine Disrupting Compounds in Sewage Treatment Plants (SPE-HPLC-DAD)
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Vidal, Carla B.

; Barbosa, Pablo G. A.

; Pessoa, Germana P.

; Buarque, Patrícia C.

; Nascimento, José G. S.

; Farias Filho, Antônio L.

; Paz, Mário S.

; Santos, André B. dos

; Cavalcante, Rivelino M.

; Nascimento, Ronaldo F.

Journal of the Brazilian Chemical Society

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Dez 2020, Volume 31 Nº 12 Páginas 2518 - 2530

Resumo: En | Texto: En | PDF: En

This work focuses on the validation and application of solid phase extraction followed by high-performance liquid chromatography (SPE-HPLC) analysis of important endocrine disruptors compounds (EDC) from different classes in highly complex wastewater matrix. The endocrine disruptors investigated included three different categories: pharmaceuticals (sulfamethoxazole (SMZ), trimethoprim (TMP) and diclofenac (DCF)), hormones (estrone (E1), 17α-ethinylestradiol (EE2) and 17β-estradiol (E2)) and plastic materials (bisphenol A (BPA)). The method involves pre-concentration by SPE using Strata-X extraction cartridges followed by HPLC coupled with diode array detector (DAD). As the assumption of homoscedasticity was met for analytical data, ordinary linear regression procedure was applied to the data. The method was considered validated for 7 EDC after consistent evaluation of the key analytical parameters. Recoveries were ranged from 52.3 to 179.6%. Limits of quantification were in the range 6.0-0.4 µg L−1. The described method was applied to evaluate the occurrence and removal efficiency of EDC in two biological sewage treatment plants (STPs). The influent mean concentrations of E1, E2 and EE2 hormones were 79.54; 175.09 and 102.19 µg L−1, respectively, while for SMZ, TMP, DCF and BPA were 215.17; 187.01; 218.97 and 87.12 µg L−1 for STP A, respectively. The efficiencies for the removal of EDCs ranged from 0 to 79.4%.

https://doi.org/10.21577/0103-5053.20200127 266 downloads

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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Nov 2020, Volume 115 Nº 5 Páginas 1006 - 1043

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

10.

Droplet Size Distribution in Water-Crude Oil Emulsions by Low-Field NMR
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Morgan, Vinícius G.

; Sad, Cristina M. S.

; Constantino, Andre F.

; Azeredo, Rodrigo B. V.

; Lacerda Jr., Valdemar

; Castro, Eustáquio V. R.

; Barbosa, Lúcio L.

Journal of the Brazilian Chemical Society

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Ago 2019, Volume 30 Nº 8 Páginas 1587 - 1598

Resumo: En | Texto: En | PDF: En

This paper reports the droplet size distribution (DSD) measurements in 28 W/O (water/oil) crude oil emulsions prepared with two Brazilian oils (medium and heavy) under different shear conditions using both 10 g L-1 NaCl solution and water production by low field nuclear magnetic resonance (NMR, 2.2 MHz). The PFGSTE (pulsed-field gradient-stimulated echo) pulse sequence applied was able to separate the crude oil emulsion signal for both medium and heavy oil even for low dispersed phase content (1.51 wt.%) and took into account only the aqueous phase signal. All emulsions exhibited an average diameter smaller than 5.5 µm because of the severe shear conditions. Despite the difficult processing of the S24 (6.48 wt.%) emulsion signal, good agreement was achieved between low field NMR and low-angle laser light scattering (LALLS) results. Finally, the paramagnetic ions in the water production did not affect the NMR measurements, demonstrating its applicability for analyzing real emulsions.

https://doi.org/10.21577/0103-5053.20190057 1507 downloads

11.

ENVIRONMENTAL VARIABLES AND QUALITY TOOLS APPLIED TO THE OPERATOR OF AN AGRICULTURAL MICROTRACTOR
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Estevam, Francisca N. de L.

; Queiroz, Renata F. de

; Damasceno, André F.

; Silva, Rouverson P. da

; Voltarelli, Murilo A.

; Barbosa Filho, José A. D.

Engenharia Agrícola

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Abr 2019, Volume 39 Nº 2 Páginas 208 - 215

Resumo: En | Texto: En | PDF: En

ABSTRACT Work in the field is characterized as unstructured because it is performed in inconvenient postures, without a fixed workstation, exposing the worker directly to the sun and other inclement weather. This may interfere in the health and the performance of the activity. The objective of this work was to characterize the environment of the agricultural microtractor operator, evaluating the thermal comfort during the activity in the municipality of Quixadá, CE. A model TC14 Super Yanmar Agritech microtractor, coupled to a rotary spindle, was used. For the measurements of the environmental variables, sensors and devices were installed on the operator and in the microtractor. The experimental design adopted the assumptions of statistical quality control. Fifteen collections were done daily at different times for three consecutive days. The data obtained were indices of thermal discomfort and thermography, both of which were analyzed by sequential graphs (run charts), control graph (Xbar-R chart), and scatter plot. At all rates, the work performed proved to be inadequate, exceeding the operator's capabilities and limitations. It was concluded that the activity performed by the microtractor operator is stressful. Measures should be taken to improve working conditions without affecting the operator's health.

https://doi.org/10.1590/1809-4430-eng.agric.v39n2p208-215/2019 624 downloads

12.

Impacto Extra-Articular do Quadril
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Barros, Antônio A. G.

; Barbosa, Victor A. K.

; Garrido, Fernando H. F.

; Ribeiro, André G.

; Costa, Lincoln P.

; Vassalo, Carlos C.

Revista Portuguesa de Ortopedia e Traumatologia

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Jun 2018, Volume 26 Nº 2 Páginas 140 - 150

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Introdução: O impacto extra-articular do quadril envolve um grupo de lesões reconhecidas apenas recentemente, comumente subdiagnosticadas e pouco compreendidas por muitos especialistas da área ortopédica. Porém, são lesões capazes de levar a dor e declínio funcional importante nos pacientes acometidos. O correto diagnóstico dessas condições é fundamental. Envolve a necessidade de um conhecimento adequado de sua patogênese e avaliação clínica através de manobras do exame físico específicas, assim como correta interpretação dos exames de imagem. Objetivo: Atualizar profissionais médicos, fisioterapeutas, educadores físicos ou quaisquer outros que trabalhem em contato direto com os pacientes acometidos. Material e métodos: Foi realizado uma revisão da literatura nas bases de dados PubMed e Birene/Lilacs a respeito da anatomia, patogênese, achados clínicos, exames de imagem e tratamento das principais causas descritas de impacto extra-articular do quadril. Resultados: As síndromes de impacto extra-articular mais citadas na literatura são os impactos isquiofemoral, subespinhal, pélvico trocantérico e o do iliopsoas. Essas síndromes são condições dinâmicas e o diagnóstico deve ser feito observando a presença de alterações anatômicas, exame clínico positivo e confirmação por exame de imagem ou achado intra-operatório. Por serem lesões com baixa prevalência relatada, existem poucas evidências a respeito dessas condições e mais estudos são necessários. Conclusão: O conhecimento das síndromes de impacto extra-articular do quadril é essencial na avaliação de pacientes com dor no quadril e deve fazer parte do diagnóstico diferencial.

Introduction: The extra-articular hip impingement involves a group of recently recognized lesions, commonly underdiagnosed and poorly understood by many orthopedic specialists. However, these lesions are capable of leading to pain and important functional decline in the affected patients. The correct diagnosis of these conditions is primal. It involves the need for an adequate knowledge of its pathogenesis and clinical evaluation through specific physical examination maneuvers, as well as correct interpretation of the imaging exams. Objective: To update medical professionals, physiotherapists, physical educators or any others who work in direct contact with the affected patients. Material and methods: A review of the literature was conducted on the PubMed and Birene /Lilacs databases on regard of anatomy, pathogenesis, clinical findings, imaging and treatment of the main causes of extra-articular hip impingement. Results: The most cited extra-articular impingement syndromes in the literature are the ischiofemoral, subspinal, trochanteric and iliopsoas impingements. These syndromes are dynamic conditions and the diagnosis must be done observing the presence of anatomical abnormalities, positive clinical examination and confirmation by imaging exams or intraoperative finding. Because they are lesions with a low prevalence reported, there is little evidence regarding these conditions and more studies are needed. Conclusion: Knowledge of extra-articular hip impingement syndromes is essential in the evaluation of patients with hip pain and should be part of the differential diagnosis.

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13.

More than kin, less than kind: one family and the many faces of diabetes in youth
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Franco, Luciana F.

; Peixoto-Barbosa, Renata

; Dotto, Renata P.

; Vieira, José Gilberto H.

; Dias-da-Silva, Magnus R.

; Reis, Luiz Carlos F.

; Giuffrida, Fernando M. A.

; Reis, Andre F.

Archives of Endocrinology and Metabolism

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Dez 2017, Volume 61 Nº 6 Páginas 637 - 642

Resumo: En | Texto: En | PDF: En

SUMMARY Identification of the correct etiology of diabetes brings important implications for clinical management. In this report, we describe a case of a 4-year old asymptomatic girl with diabetes since age 2, along with several individuals in her family with different etiologies for hyperglycemia identified in youth. Genetic analyses were made by Sanger sequencing, laboratory measurements included HbA1c, lipid profile, fasting C-peptide, pancreatic auto-antibodies (glutamic acid decarboxylase [GAD], Islet Antigen 2 [IA-2], and anti-insulin). We found a Gly178Ala substitution in exon 5 of GCK gene in three individuals co-segregating with diabetes, and type 1 diabetes was identified in two other individuals based on clinical and laboratory data. One individual with previous gestational diabetes and other with prediabetes were also described. We discuss difficulties in defining etiology of hyperglycemia in youth in clinical practice, especially monogenic forms of diabetes, in spite of the availability of several genetic, laboratory, and clinical tools.

https://doi.org/10.1590/2359-3997000000312 940 downloads

14.

Volatile Organic Compounds from Filamentous Fungi: a Chemotaxonomic Tool of the Botryosphaeriaceae Family
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Oliveira, Francisco C.

; Barbosa, Francisco G.

; Mafezoli, Jair

; Oliveira, Maria C. F.

; Camelo, André L. M.

; Longhinotti, Elisane

; Lima, Ari C. A.

; Câmara, Marcos P. S.

; Gonçalves, Francisco J. T.

; Freire, Francisco C. O.

Journal of the Brazilian Chemical Society

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Nov 2015, Volume 26 Nº 11 Páginas 2189 - 2194

Resumo: En | Texto: En | PDF: En

Volatile organic compounds (VOCs) from ten endophytic fungal species belonging to the Botryosphaeriaceae family were extracted by headspace-solid phase micro-extraction (HS-SPME) and analyzed by gas chromatography-mass spectrometry (GC-MS). Thirty-four VOCs were identified. Most of the compounds are sesquiterpenes (14 non-oxygenated and 10 oxygenated), and two linear ketones and eight alcohols were also identified. Multivariate data analysis (PCA and HCA) allowed the differentiation of all investigated species, and proved to be efficient for the differentiation of Neofusicocum parvum and N. ribis, which are considered very similar species. α-Bisabolol, α-selinene, α-cedrene epoxide and guaiol acetate were suggested as biomarkers.

https://doi.org/10.5935/0103-5053.20150204 2599 downloads

15.

An Investigation of a Mathematical Model for the Internal Velocity Profile of Conical Diffusers Applied to DAWTs
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BARBOSA, DISTERFANO L.M.

; VAZ, JERSON R.P.

; FIGUEIREDO, SÁVIO W.O.

; SILVA, MARCELO DE OLIVEIRA E

; LINS, ERB F.

; MESQUITA, ANDRÉ L.A.

Anais da Academia Brasileira de Ciências

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Jun 2015, Volume 87 Nº 2 Páginas 1133 - 1148

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Difusores de aumento da potência de turbinas eólicas (DAWTs) têm sido amplamente estudados, uma vez que os difusores melhoraram o coeficiente de potência de turbinas eólicas, particularmente dos sistemas de pequeno porte. O difusor é um dispositivo que tem a função de provocar um aumento da velocidade do vento que passa através do plano do rotor eólico, devido a queda de pressão a jusante do difusor, por conseguinte, resultando em um aumento do coeficiente de potência do rotor. Esta tecnologia faz com que a turbina exceda o limite de Betz, onde a energia cinética máxima extraída do fluxo é de 59,26%. Assim, o presente estudo propõe um modelo matemático que descreva o comportamento do perfil de velocidade interna a três difusores cônicos, considerando as características do escoamento em torno deles. O modelo proposto baseia-se na lei de Biot-Savart, em que o filamento de vórtice induz um campo de velocidade num ponto arbitrário nos eixos de simetria dos difusores. Os resultados são comparados com dados experimentais obtidos para os três difusores, apresentando boa concordância.

The Diffuser Augmented Wind Turbines (DAWTs) have been widely studied, since the diffusers improve the power coefficient of the wind turbine, particularly of small systems. The diffuser is a device which has the function of causing an increase on the flow velocity through the wind rotor plane due to pressure drop downstream, therefore resulting in an increase of the rotor power coefficient. This technology aids the turbine to exceed the Betz limit, which states that the maximum kinetic energy extracted from the flow is 59.26%. Thus, the present study proposes a mathematical model describing the behavior of the internal velocity for three conical diffusers, taking into account the characteristics of flow around them. The proposed model is based on the Biot-Savart's Law, in which the vortex filament induces a velocity field at an arbitrary point on the axis of symmetry of the diffusers. The results are compared with experimental data obtained for the three diffusers, and present good agreement.

https://doi.org/10.1590/0001-3765201520140114 3805 downloads

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