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ABSTRACT: The clinical syndrome of the pituitary pars intermedia dysfunction (PPID) is the most common endocrinopathy of older horses. This syndrome is characterized by several clinical and pathological changes, which are usually associated with adenomas of the pars intermedia (PI) of the pituitary gland. The aim of this work is to describe five cases of pituitary adenoma of the PI associated with PPID in horses, addressing its clinical and pathological aspects. The horses had a mean of 22 years of age. The main clinical signs were hirsutism and paresis of hind limbs, and at post mortem examination all horses had hirsutism, and a nodule in the pituitary gland, which was histologically characterized as an adenoma of PI (5/5). Furthermore, two horses had gross lesions suggestive of chronic laminitis. Moreover, there was intense parasitism of Sarcocystis neurona (2/5), Strongylus vulgaris (1/5), Parascaris equorum (1/5), Draschia megastoma (1/5), and Klossiella equi (1/5).

RESUMO: A síndrome clínica da disfunção da pars intermedia da hipófise (PPID) é a endocrinopatia mais comum em cavalos idosos. Essa síndrome é caracterizada por várias alterações clínicas e patológicas, geralmente associadas a adenomas da pars intermedia (PI) da hipófise. O objetivo deste trabalho é descrever cinco casos de adenoma hipofisário de PI associado a PPID em equinos, abordando seus aspectos clínicos e patológicos. Os cavalos apresentaram média de 22 anos de idade. Os principais sinais clínicos incluíam hirsutismo e paresia dos membros pélvicos, e no exame post mortem todos os equinos apresentavam hirsutismo e um nódulo na glândula pituitária, que foi histologicamente caracterizada como um adenoma de PI (5/5). Além disso, dois cavalos tinham lesões macroscópicas sugestivas de laminite crônica. Ainda, havia intenso parasitismo de Sarcocystis neurona (2/5), Strongylus vulgaris (1/5), Parascaris equorum (1/5), Draschia megastoma (1/5) e Klossiella equi (1/5).

https://doi.org/10.1590/1678-5150-pvb-7117

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 Nº 1 elocation e20200452

Resumo: En | Texto: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

Development and Validation of a Rapid and Reliable RP-HPLC-PDA Method for the Quantification of Six Diterpenes in Copaifera duckei, Copaifera reticulata and Copaifera multijuga Oleoresins
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Carneiro, Luiza J.

; Bianchi, Thamires C.

; Silva, Jonas J. M. da

; Oliveira, Larissa C.

; Borges, Carly H. G.

; Lemes, Danieli C.

; Bastos, Jairo K.

; Veneziani, Rodrigo C. S.

; Ambrósio, Sérgio R.

Journal of the Brazilian Chemical Society

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Abr 2018, Volume 29 Nº 4 Páginas 729 - 737

Resumo: En | Texto: En | PDF: En

Oleoresins from Copaifera species are extensively used in folk medicine in Brazil, which are employed mainly in the production of cosmetic formulations in Brazil, North America and Europe. Considering the lack of validated analytical methods for the analyses of diterpenes in Copaifera oleoresins, it was developed a validated and reliable reversed-phase high-performance liquid chromatography with photodiode array detection (RP-HPLC-PDA) method for the analysis of six diterpenes, including: (-)-polyalthic acid; (13E)-ent-labda-7,13-dien-15-oic acid; ent-8(17)-labden-15,18-dioic acid; (-)-copalic acid; (-)-3β-acetoxycopalic acid and (-)-3β-hydroxycopalic acid. These compounds were isolated from C. duckei, C. reticulata and C. multijuga oleoresins by chromatographic means. The analytical curves were linear with regression coefficients (r2) between 0.9903 and 0.9999. The limits of detection (LOD) and quantification (LOQ) values were 0.35 to 3.09 µg mL-1 and 1.05 to 9.36 µg mL-1, respectively. The method also displayed good precision and accuracy. The developed analytical method is reliable and a useful tool for the analysis of Copaifera oleoresin and its products.

https://doi.org/10.21577/0103-5053.20170195 776 downloads

Pelvic Floor 3D Ultrasound of Women with a TVT, TVT-O, or TVT-S for Stress Urinary Incontinence at the Three-year Follow-up
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Rodrigues, Claudinei A.

; Bianchi-Ferraro, Ana Maria H. M.

; Zucchi, Eliana Viana Monteiro

; Sartori, Marair G. F.

; Girão, Manoel J. B. C.

; Bella, Zsuzsanna I. K. Jarmy-Di

Revista Brasileira de Ginecologia e Obstetrícia

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Set 2017, Volume 39 Nº 9 Páginas 471 - 479

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Comparar por meio de ultrassom tridimensional (US-3D) a posição e o ângulo entre os braços da faixa, em diferentes técnicas de inserção de sling de uretra média, para tratamento de incontinência urinária de esforço, 3 anos após a cirurgia, correlacionando os achados ultrassonográficos aos resultados clínicos pós-operatórios. Métodos Este é umestudo de coorte transversal prospectivo de 170 pacientes que se submeteram a um procedimento de sling entremaio de 2009 e dezembro de 2011. Foi possível avaliar as imagens de US em 105 pacientes: 26 com tension-free vaginal tape (TVT), 42 com tension-free vaginal tape-obturator (TVT-O) e 37 com tension-free vaginal tape-Secur (TVT-S). As imagens (em repouso, em manobra de Valsalva e em contração perineal) foram analisadas por dois observadores diferentes, que desconheciam o tipo de sling utilizado na cirurgia, assimcomo as queixas da paciente. A análise estatística foi realizada por meio dos testes t de Student, qui-quadrado, Kruskal-Wallis, e análise de variância com comparações múltiplas de Tukey. Resultados As médias dos ângulos entre os braços da faixa foram: TVT = 119,94°, TVT-O = 141,93°, TVT-S = 121,06° (p < 0,001). As médias das distâncias entre o colo vesical e a faixa, em repouso, foram: TVT = 1,65 cm, TVT-O = 1,93 cm, TVTS = 1,95 cm (p = 0,010). A taxa de cura objetiva dos slings foi de 87,8% (TVT = 88,5%, TVT-O = 90,5% e TVT-S = 83,8%; p = 0,701). A taxa de cura subjetiva foi de 83,8% (TVT = 88,5%, TVT-O = 88,5% e TVT-S = 78,4%; p = 0,514). Os slings estavam na uretra média em 85,7% (TVT = 100%, TVT-O = 73,8% e TVT-S = 89,2%; p = 0,001) dos pacientes, e a localização mais distal foi associada a obesidade (distal: 66,7% obesas; uretra média: 34% obesas; p = 0.003). Os sintomas de urgência foram observados em 23,8% das pacientes (TVT = 30,8%, TVT-O = 21,4%, TVT-S = 21,6%; p = 0,630). Não houve diferenças significativas quando se comparam os achados ultrassonográficos e os grupos de pacientes com sintomas de urgência, cura subjetiva e objetiva. Conclusão O ângulo formado pelos braços da faixa foi mais obtuso noTVT-Oquando comparado com o TVT ou o TVT-S. Os TVTs foram localizados mais frequentemente na uretra média quando comparados com os outros dois grupos, mesmo em pacientes obesas. Entretanto, as medidas ultrassonográficas não tiveram correlação com os sintomas urinários três anos após a cirurgia.

Abstract Objective Using three-dimensional ultrasound (3D-US), we aimed to compare the tape position and the angle formed by the sling arms in different techniques of midurethral sling insertion for the surgical treatment of stress urinary incontinence, three years after surgery. In addition, we examined the correlations between the US findings and the clinical late postoperative results. Methods A prospective cross-sectional cohort study of 170 patients who underwent a sling procedure between May 2009 and December 2011 was performed. The final sample, with US images of sufficient quality, included 26 retropubic slings (tension-free vaginal tape, TVT), 42 transobturator slings (tension-free vaginal tape-obturator, TVTO), and 37 single-incision slings (tension-free vaginal tape-Secur, TVT-S). The images (at rest, during the Valsalva maneuver, and during pelvic floor contraction) were analyzed offline by 2 different observers blinded against the surgical and urinary continence status. Group comparisons were performed using the Student t-test, the chi-squared and the Kruskal-Wallis tests, and analyses of variance with Tukey multiple comparisons. Results Differences among the groups were found in themean angle of the tape arms (TVT = 119.94°, TVT-O = 141.93°, TVT-S = 121.06°; p < 0.001) and in the distance between the bladder neck and the tape at rest (TVT = 1.65 cm, TVT-O = 1.93 cm, TVTS = 1.95 cm; p = 0.010). The global objective cure rate was of 87.8% (TVT = 88.5%, TVT-O = 90.5%, TVT-S = 83.8%; p = 0.701). The overall subjective cure rate was of 83.8% (TVT = 88.5%, TVT-O = 88.5% and TVT-S = 78.4%; p = 0.514). The slings were located in the mid-urethra in 85.7% of the patients (TVT = 100%, TVT-O = 73.8%, TVTS = 89.2%; p = 0.001), with a more distal location associated with obesity (distal: 66.7% obese; mid-urethra: 34% obese; p = 0.003). Urgency-related symptoms were observed in 23.8% of the patients (TVT = 30.8%, TVT-O = 21.4%, TVT-S = 21.6%; p = 0.630). Conclusions The angle formed by the arms of the sling tape was more obtuse for the transobturator slings compared with the angles for the retropubic or single-incision slings. Retropubic slings were more frequently located in the mid-urethra compared with the other slings, regardless of obesity. However, the analyzed sonographic measures did not correlate with the urinary symptoms three years after the surgery.

https://doi.org/10.1055/s-0037-1606125 1430 downloads

Determination of Elemental Impurities in Acyclovir Ointment and Raw Materials Using Microwave Acid Digestion (MW-AD) and ICP-MS
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Gonzalez, Mario H.

; Silva, Caroline S. da

; Amaral, Clarice D. B.

; Bianchi, Silmara R.

; Oliveira, Luciano H. B. de

; Coelho, Jéssica S.

; Oliveira, Andrea

; Nogueira, Ana Rita A.

Journal of the Brazilian Chemical Society

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Jan 2017, Volume 28 Nº 1 Páginas 98 - 105

Resumo: En | Texto: En | PDF: En

Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+, 65Cu+, 52Cr+, 58Ni+, 208Pb+, and 51V+, were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+, 52Cr+, 58Ni+, 65Cu+, 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr.

https://doi.org/10.5935/0103-5053.20160151 1863 downloads

Adding palm oil to the diet of sheep alters fatty acids profile on yogurt: Benefits to consumers
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BIANCHI, ANDERSON E.

; SILVA, ALEKSANDRO S. DA

; BIAZUS, ANGELISA H.

; RICHARDS, NEILA S.P.S.

; PELLEGRINI, LUIS G.

; BALDISSERA, MATHEUS D.

; MACEDO, VICENTE P.

; SILVEIRA, ANDRÉ L.F. DA

Anais da Academia Brasileira de Ciências

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2017, Volume 89 Nº 3 Páginas 2471 - 2478

Resumo: En | Texto: En | PDF: En

ABSTRACT The aim of this study was to modify the fatty acid profile of yogurt from sheep milk by the inclusion of different concentrations of palm oil into their diet. Thus, thirty-six sheep during lactation were separated in four groups with nine animals each, as described below: the group T0 (0%); the group T2 (inclusion of 2% of palm oil); the group T4 (inclusion of 4% of palm oil) and the group T6 (inclusion of 6% of palm oil). After 60 days of the supplementation, milk samples were collected and yogurt was produced, which was evaluated regarding the concentration of saturated fatty acids (SFA), monounsaturated fatty acids (MFA), and polyunsaturated fatty acids (PFA). A significant reduction (p<0.05) in most SFA and a significant increase (p<0.05) on MFA and PFA was observed in the yogurt of sheep supplemented with 4 and 6% of palm oil. Consequently, it is possible to conclude that palm oil supplementation exerts positive effects on yogurt, since it led to the reduction of undesirable fatty acids and increased fatty acids beneficial to human health.

https://doi.org/10.1590/0001-3765201720170468 1386 downloads

Development and Test of an Equipment to Measure Residual Strain Inside Pipes Using the Hole-Drilling Method
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Silva, Luiz Leite da

; Ribeiro, Vladimir S.

; Scaldaferri, Denis H. Bianchi

; Rabello, Emerson Giovanni

; Campos, Wagner R. C.

; Mansur, Tanius R.

Latin American Journal of Solids and Structures

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Dez 2016, Volume 13 Nº 13 Páginas 2439 - 2450

Resumo: En | Texto: En | PDF: En

Abstract Residual stresses are present in materials or structural component in the absence of external loads or changes in temperatures. The most common causes of residual stresses being present are the manufacturing or assembling processes. All manufacturing processes, such as casting, welding, machining, moulding, heat treatment, etc, introduces residual stresses into the manufactured object. The residual stresses effects could be beneficial or detrimental, depending on its distribution related to the component or structure, its load service and if they are compressive or tensile. In order to do the studies of residual stresses inside pipes, where the fatigue cracks normally initiate, an equipment that allows applying the Hole-Drilling Method was developed. The equipment efficacy was confirmed in this work by using it to detect residual strains inside a Mock-up that simulates the relief and security nozzle of Angra 1 Nuclear Power Plant (NPP) pressuriser.

https://doi.org/10.1590/1679-78253126 1414 downloads

Haematological reference for red-browed parrot ( Amazona rhodocorytha , Salvadori, 1890) captive in the Atlantic Forest in Eastern Brazil
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Mello, R.H.

; Martins, R.F.

; Bonissi, D.A.

; Júnior, J.L.B.

; Melotti, T.

; Bianchi, H.

; Bianchi, M.A.F.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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Out 2016, Volume 68 Nº 5 Páginas 1275 - 1282

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Para a realização da presente pesquisa, foram utilizados 35 (trinta e cinco) papagaios-chauás (A. rhodocorytha), adultos, cativos, de ambos os sexos e clinicamente saudáveis, pertencentes ao acervo vivo do Museu de Biologia Professor Mello Leitão, localizado em Santa Teresa, Espírito Santo, Brasil. As coletas foram realizadas pela manhã, por meio da punção da veia braquial, obtendo-se 0,5mL de sangue, armazenado em EDTA por um período máximo de seis horas. Foram confeccionados esfregaços sanguíneos de material fresco no momento da coleta, posteriormente corados pelo método May-Grunwald-Giensa. A análise dos elementos sanguíneos foi feita por meio de contagem celular em câmara de Neubauer espelhada, utilizando-se como diluente a solução de Natt e Herrick na proporção de 2:200. Para a análise de hemoglobinometria, foi utilizada a metodologia do cianeto de hemoglobina, utilizando-se kits comerciais por colorimetria em um analisador bioquímico semiautomático. Depois de realizada a estatística dos dados, obtiveram-se os seguintes parâmetros (média±desvio-padrão): hemácias (x106/μL): 2,68±0,56; hemoglobina (g/dL): 14,27±0,69; hematócrito (%): 53±3,38; volume corpuscular médio (fL): 206,7±45,82; hemoglobina corpuscular média (pg): 56,4±14,46; concentração hemoglobina corpuscular média (%): 27,5±1,19; trombócitos (x3/μL): 25,8±10,5; proteína plasmática total (g/dL) 5,4±0,5; leucócitos (x103/dL): 3,1±2; heterófilos (/µL): 1937±1676; linfócitos (/µL): 1144±599; monócitos (/µL): 24,4±28,2; basófilos (/µL): 42,2±46,2; eosinófilos (/µL): 11,7±19,9. Na relação entre machos e fêmeas, não foi encontrada diferença estatística relevante em nenhum parâmetro hematológico avaliado.

ABSTRACT To conduct the survey were used 35 (thirty-five) red-browned parrots (A. rhodocorytha), adults, captive, of both genders and clinically healthy, belonging to the live collection of the Museum of Biology Teacher Mello Leitao, located in Santa Teresa, Espírito Santo, Brazil. Harvests were performed in the morning, by puncture of the brachial vein getting 0.5mL of blood stored in EDTA for a period no longer than 6 hours. Blood smears of fresh material were made at collection, stained using the method of May-Grunwald-Giemsa. Analysis of blood elements was done by cell counting in a mirrored Neubauer chamber using Natt and Herrick solution at a ratio of 2:200 as diluent. For the analysis of the methodology, homoglobinometry cyanide hemoglobin using commercial kits by colorimetry on a semi-automatic biochemical analyzer was used. After completion of the statistical data the following parameters were obtained (mean±standard deviation): Erythrocytes (x106/μl): 2.68±0.56; Hemoglobin (g/dl): 14.27±0.69; Hematocrit (%): 53±3.38; Mean corpuscular volume (fl): 206.7±45.82; Mean corpuscular hemoglobin (pg): 56.4±14.46; Mean corpuscular hemoglobin concentration (%): 27.5±1.19; Thrombocytes (x3/μl): 25.8 ± 10.5; Total plasma protein (g/dl) 5.4±0.5; Leukocytes (x103/dl): 3.1±2; Heterophile (/uL): 1937±1676; Lymphocytes (/uL): 1144±599; Monocytes (/uL): 24.4 ± 28.2; Basophils (/uL): 42.2±46.2; Eosinophils (/uL): 11.7±19.9. In the relation between males and females, no significant differences were found in any hematological parameter evaluated.

https://doi.org/10.1590/1678-4162-8600 1623 downloads

Restrain of birds with bottles of polyethylene terephthalate, tested in red-browed from the Atlantic Forest
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Bianchi, M.A.F.

; Mello, R.H.

; Bianchi, H.

; Bermond Júnior, J.L.

; Ibrahim, P.A.F.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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Fev 2016, Volume 68 Nº 1 Páginas 136 - 140

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Em animais silvestres, a contenção é o momento de maior estresse promovido pelo pesquisador ao animal, devido à resistência natural ao momento da captura, ao manuseio, à contenção e ao transporte, atitudes francamente contrárias à sua índole. Em aves, a contenção deve obedecer a alguns critérios, com o objetivo de controlar os movimentos do animal, evitando traumas, ao mesmo tempo em que é preciso manter sua amplitude respiratória. O alto risco de morte, durante a contenção desses animais, suscitou a concepção de um dispositivo, proveniente de garrafas de politereftalato de etileno (PET), para a contenção de papagaios-chauá (Amazona rhodocorytha), psitacídeo endêmico da Mata Atlântica, na região Sudeste do Brasil, e ameaçado de extinção. Esse dispositivo permitiu a observação dos movimentos respiratórios, a diminuição do tempo de manuseio das aves, para coleta de materiais biológicos, e a consequente redução do estresse e dos riscos de morte, durante a avaliação de diversos dados biológicos e sanitários dessa ave. Tal contenção pode ser utilizada como modelo para qualquer outra ave, desde que se adapte o tamanho do animal, ao recipiente de garrafa PET.

In wild animals, containment is the moment of greatest stress caused by the investigator to the animal due to its natural resistance to the moment of capture, handling, containment and transport, attitudes frankly contrary to his nature. In birds, the restraint must meet certain criteria in order to control the animal's movements, avoiding trauma at the same time that you need to keep your breathing amplitude. The high risk of death during the restraint of these animals raised the need to design a device, from bottles of poly ethylene terephthalate (PET), for containing parrots-browed Amazon (Amazona rhodocorytha), a parrot endemic to the Atlantic Forest in southeastern Brazil, and endangered with extinction, which allowed the observation of respiration, the reduction of handling time of birds for collection of biological material, and consequent reduction of stress and risk of death during the evaluation of several biological data and health of the bird. The PET bottle container can be used as a model for any bird, provided it suits the size of the animal.

https://doi.org/10.1590/1678-4162-8604 1974 downloads

10.

Qualidade de vida nas espondiloartrites: análise de uma grande coorte brasileira
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Ribeiro, Sandra L.E.

; Albuquerque, Elisa N.

; Bortoluzzo, Adriana B.

; Gonçalves, Célio R.

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M.S.

; Costa, Izaias P.

; Duarte, Angela L.B. Pinto

; Kohem, Charles L.

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D.

Revista Brasileira de Reumatologia

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Fev 2016, Volume 56 Nº 1 Páginas 22 - 27

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Analisar as variáveis demográficas e clínicas associadas à diminuição da qualidade de vida em uma grande coorte brasileira de pacientes com espondiloartrite (EpA). Métodos: Foi aplicado um protocolo de pesquisa único a 1.465 pacientes brasileiros classificados como tendo EpA de acordo com os critérios do European Spondyloarthropaties Study Group (ESSG), atendidos em 29 centros de referência em reumatologia do Brasil. Foram registradas as variáveis clínicas e demográficas. A qualidade de vida foi analisada por meio do questionário Ankylosing Spondylitis Quality of Life (ASQoL). Resultados: A pontuação média do ASQoL foi de 7,74 (+ 5,39). Ao analisar doenças específicas no grupo de EpA, as pontuações do ASQoL não apresentaram diferença estatisticamente significativa. Os dados demográficos mostraram piores escores de ASQoL associados ao gênero feminino (p = 0,014) e etnia negra (p < 0,001). Quanto aos sintomas clínicos, a dor na região glútea (p = 0,032), a dor cervical (p < 0,001) e a dor no quadril (p = 0,001), estiveram estatisticamente associadas a piores escores no ASQoL. O uso contínuo de fármacos anti-inflamatórios não esteroides (p < 0,001) e agentes biológicos (p = 0,044) esteve associado a escores mais elevados de ASQoL, enquanto outros medicamentos não interferiram nos escores do ASQoL. Conclusão: Nesta grande série de pacientes com EpA, o sexo feminino e a etnia negra, bem como sintomas predominantemente axiais, estiveram associados a uma qualidade de vida reduzida.

Abstract Objective: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). Methods: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: The mean ASQoL score was 7.74 (± 5.39). When analyzing the specific diseases in the SpA group, the ASQoL scores did not present statistical significance. Demographic data showed worse scores of ASQoL associated with female gender (p = 0.014) and African-Brazilian ethnicity (p < 0.001). Regarding clinical symptoms, buttock pain (p = 0.032), cervical pain (p < 0.001) and hip pain (p = 0.001), were statistically associated with worse scores of ASQoL. Continuous use of nonsteroidal anti-inflammatory drugs (p < 0.001) and biologic agents (p = 0.044) were associated with higher scores of ASQoL, while the other medications did not interfere with the ASQoL scores. Conclusion: In this large series of patients with SpA, female gender and African-Brazilian ethnicity, as well as predominant axial symptoms, were associated with impaired quality of life.

https://doi.org/10.1016/j.rbr.2015.03.003 3358 downloads

11.

Avaliação do desempenho do BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) numa coorte brasileira de 1.492 pacientes com espondiloartrites: dados do Registro Brasileiro de Espondiloartrites (RBE)
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Costa, Izaias Pereira da

; Bortoluzzo, Adriana B.

; Gonçalves, Célio R.

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Ribeiro, Sandra L.E.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Albuquerque, Elisa N.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M.S.

; Duarte, Angela L.B. Pinto

; Kohem, Charles L.

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D.

Revista Brasileira de Reumatologia

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Fev 2015, Volume 55 Nº 1 Páginas 48 - 54

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objetivo Avaliar os resultados da aplicação do Índice de Atividade de Doença da Espondilite Anquilosante de Bath (BASDAI) numa série de pacientes brasileiros com EpA e estabelecer suas correlações com as variáveis específicas do grupo. Métodos Um protocolo comum de investigação foi prospectivamente aplicado em 1.492 pacientes brasileiros classificados como EpA pelos critérios do Grupo Europeu de Estudo das Espondiloartropatias (ESSG), acompanhados em 29 centros de referência em reumatologia no Brasil. Variáveis clínicas, demográficas e índices de doença foram colhidos. Os valores totais do BASDAI foram comparados com a presença das diferentes variáveis. Resultados O valor médio do BASDAI foi de 4,20 ± 2,38. Os escores médios do BASDAI foram mais elevados nos pacientes com forma clínica combinada, comparado às formas axiais e periféricas isoladas, nos pacientes do sexo feminino e nos sedentários. Com relação ao componente axial, valores mais altos do BASDAI estiveram significativamente associados à lombalgia inflamatória, à dor alternante em nádegas, à dor cervical e ao acometimento de coxofemorais. Houve associação estatística entre os valores do BASDAI e o comprometimento periférico, relacionado ao número de articulações inflamadas, tanto dos membros inferiores quanto dos membros superiores, e às entesites. A positividade do HLA-B27 e a presença de manifestações extra-articulares não estiveram correlacionadas com os valores médios do BASDAI. Valores mais baixos do BASDAI estiveram associados ao uso de agentes biológicos (p < 0,001). Conclusão Nesta série heterogênea de pacientes brasileiros com EpA, o BASDAI conseguiu demonstrar “atividade de doença” tanto nos pacientes com acometimento axial quanto naqueles com envolvimento periférico.

Objective To analyze the results of the application of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in a large series of Brazilian patients with the diagnosis of SpA and establish its correlations with specific variables into the group. Methods A common protocol of investigation was prospectively applied to 1492 Brazilian patients classified as SpA according to the European Spondyoarthropathies Study Group (ESSG), attended at 29 referral centers of Rheumatology in Brazil. Clinical and demographic variables, and disease indices (BASDAI, Basfi, Basri, Mases, ASQol) were applied. The total values of BASDAI were compared to the presence of the different variables. Results The mean score of BASDAI was 4.20 ± 2.38. The mean scores of BASDAI were higher in patients with the combined (axial + peripheral + entheseal) (4.54 ± 2.38) clinical presentation, compared to the pure axial (3.78 ± 2.27) or pure peripheral (4.00 ± 2.38) clinical presentations (P < 0.001). BASDAI also presented higher scores associated with the female gender (P < 0.001) and patients who did not practice exercises (P < 0.001). Regarding the axial component, higher values of BASDAI were significantly associated with inflammatory low back pain (P < 0.049), alternating buttock pain (P < 0.001), cervical pain (P < 0.001) and hip involvement (P < 0.001). There was also statistical association between BASDAI scores and the peripheral involvement, related to the lower (P = 0.004) and upper limbs (P = 0.025). The presence of enthesitis was also associated to higher scores of BASDAI (P = 0.040). Positive HLA-B27 and the presence of cutaneous psoriasis, inflammatory bowel disease, uveitis and urethritis were not correlated with the mean scores of BASDAI. Lower scores of BASDAI were associated with the use of biologic agents (P < 0.001). Conclusion In this heterogeneous Brazilian series of SpA patients, BASDAI was able to demonstrate “disease activity” in patients with axial as well as peripheral disease.

https://doi.org/10.1016/j.rbr.2014.05.005 12259 downloads

12.

Perfil do uso de drogas modificadoras de doença no Registro Brasileiro de Espondiloartrites
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Kohem, Charles L

; Bortoluzzo, Adriana B

; Gonçalves, Célio R

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Ribeiro, Sandra L.E.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Albuquerque, Elisa N.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M. S.

; Costa, Izaias Pereira da

; Duarte, Angela L.B. Pinto

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D

Revista Brasileira de Reumatologia

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Fev 2014, Volume 54 Nº 1 Páginas 33 - 37

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Introdução: Poucos estudos avaliaram o perfil do uso de drogas modificadoras de doença (DMD) em pacientes brasileiros com diagnóstico de espondiloartrite (EpA). Métodos: Um protocolo comum de investigação foi prospectivamente aplicado em 1505 pacientes classificados como EpA pelos critérios do Grupo Europeu de Estudo das Espondiloartrites (ESSG), acompanhados em 29 centros de referência em Reumatologia no Brasil. Variáveis clínicas e demográficas foram obtidas e avaliadas, analisando-se suas correlações com o uso das DMD metotrexato (MTX) e sulfasalazina (SSZ). Resultados: Pelo menos uma DMD foi utilizada por 73,6% dos pacientes, sendo MTX por 29,2% e SSZ por 21,7%, enquanto 22,7% utilizaram ambas as drogas. O uso do MTX foi significativamente associado ao acometimento periférico, e a SSZ foi associada ao comprometimento axial, sendo que as duas drogas foram mais utilizadas, isoladas ou combinadas, no comprometimento misto (p < 0,001). O uso de uma DMD esteve significativamente associado à etnia branca (MTX; p = 0,014), lombalgia inflamatória (SSZ; p = 0,002), dor em nádegas (SSZ; p = 0,030), cervicalgia (MTX; p = 0,042), artrite de membros inferiores (MTX; p < 0,001), artrite de membros superiores (MTX; p < 0,001), entesite (p = 0,007), dactilite (MTX; p < 0,001), doença inflamatória intestinal (SSZ; p < 0,001) e acometimento ungueal (MTX; p < 0,001). Conclusão: O uso de pelo menos uma DMD foi referido por mais de 70% dos pacientes numa grande coorte brasileira de pacientes com EpA, sendo o uso do MTX mais associado ao acometimento periférico e o uso da SSZ mais associado ao acometimento axial.

Introduction: Few studies have evaluated the profile of use of disease modifying drugs (DMD) in Brazilian patients with spondyloarthritis (SpA). Methods: A common research protocol was applied prospectively in 1505 patients classified as SpA by criteria of the European Spondyloarthropathies Study Group (ESSG), followed at 29 referral centers in Rheumatology in Brazil. Demographic and clinical variables were obtained and evaluated, by analyzing their correlation with the use of DMDs methotrexate (MTX) and sulfasalazine (SSZ). Results: At least one DMD was used by 73.6 % of patients: MTX by 29.2 % and SSZ by 21.7%, while 22.7 % used both drugs. The use of MTX was significantly associated with peripheral involvement, and SSZ was associated with axial involvement, and the two drugs were more administered, separately or in combination, in the mixed involvement (p < 0.001). The use of a DMD was significantly associated with Caucasian ethnicity (MTX , p = 0.014), inflammatory back pain (SSZ, p = 0.002) , buttock pain (SSZ, p = 0.030), neck pain (MTX, p = 0.042), arthritis of the lower limbs (MTX, p < 0.001), arthritis of the upper limbs (MTX, p < 0.001), enthesitis (p = 0.007), dactylitis (MTX, p < 0.001), inflammatory bowel disease (SSZ, p < 0.001) and nail involvement (MTX, p < 0.001). Conclusion: The use of at least one DMD was reported by more than 70% of patients in a large cohort of Brazilian patients with SpA, with MTX use more associated with peripheral involvement and the use of SSZ more associated with axial involvement.

https://doi.org/10.1016/j.rbr.2013.06.003 2823 downloads

13.

Association among H. pylori virulence markers dupA, cagA and vacA in Brazilian patients
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Pereira, Weendelly Nayara

; Ferraz, Mariane Avante

; Zabaglia, Luanna Munhoz

; Labio, Roger William de

; Orcini, Wilson Aparecido

; Ximenez, João Paulo Bianchi

; Caleman Neto, Agostinho

; Payão, Spencer Luiz Marques

; Rasmussen, Lucas Trevizani

Journal of Venomous Animals and Toxins including Tropical Diseases

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2014, Volume 20 elocation 1

Resumo: En | Texto: En | PDF: En

Background:Only a few Helicobacter pylori-infected individuals develop severe gastric diseases and virulence factors of H. pyloriappear to be involved in such clinical outcomes. Duodenal ulcer promoting gene A (dupA) is a novel virulence factor ofHelicobacter pylori that is associated with duodenal ulcer development and reduced risk for gastric carcinoma in some populations. The aims of the present study were to determine the presence ofdupA gene and evaluate the association amongdupA and other virulence factors includingcagA and vacA in Brazilian patients. Gastric biopsies were obtained from 205 dyspeptic patients (100 children and 105 adults). DNA was extracted and analyzed for the presence of H. pylori and its virulence factors using the polymerase chain reaction method.Results:Patients with gastritis tested positive for H. pylori more frequently. The dupA gene was detected in 41.5% of them (85/205); cagA gene was found in 98 isolates (47.8%) andvacA genotype s1/m1 in 50.2%, s1/m2 in 8.3%, s2/m2 in 36.6%, s2/m1 in 0.5% and s1/s2/m1/m2 in 4.4%. We also verified a significant association between cagA and dupA genes [p = 0.0003, relative risk (RR) 1.73 and confidence interval [CI] = 1.3-2.3]. The genotypes s1/m1 were also associated with dupA gene (p = 0.0001, RR: 1.72 and CI: 1.3-2.2). The same associations were found when analyzing pediatric and adult groups of patients individually.Conclusion:Ours results suggest that dupA is highly frequent in Brazilian patients and is associated with cagA gene andvacA s1/m1 genotype, and it may be considered an important virulence factor in the development of gastric diseases in adults or children.

https://doi.org/10.1186/1678-9199-20-1 1103 downloads

14.

RP-HPLC analysis of manool-rich Salvia officinalis extract and its antimicrobial activity against bacteria associated with dental caries
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Moreira, Monique R.

; Souza, Ariana B.

; Moreira, Maísa A.

; Bianchi, Thamires C.

; Carneiro, Luiza J.

; Estrela, Fernanda T.

; Santos, Raquel A. dos

; Januário, Ana H.

; Martins, Carlos H.G.

; Ambrosio, Sérgio R.

; Veneziani, Rodrigo C.S.

Revista Brasileira de Farmacognosia

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Dez 2013, Volume 23 Nº 6 Páginas 870 - 876

Resumo: En | Texto: En | PDF: En

In this paper we screened the dichloromethane extract from the aerial parts of Salvia officinalis L., Lamiaceae, against a representative panel of microorganisms that cause caries, conducted a bioassay-guided fractionation to establish themselves the most active metabolite (manool) and determined the Salvia officinalis fraction with the manool highest concentration to be used to activate an ingredient in oral care products such as toothpastes and mouthwashes. Both manool and S. officinalis extract showed very promising minimal inhibitory concentration values (between 6.24 and 31.36 µg.ml-1) and time kill curves against the primary causative agents of dental caries (Streptococcus mutans) revealed that, at twice its minimal bactericidal concentration (12.48 µg.ml-1), manool required 6 h to completely kill the bacteria. Salvia officinalis extract at twice its minimal bactericidal concentration (31.36 µg.ml-1) needed 12 h. The results achieved with Salvia officinalis extract motivated us to develop and validate an analytical RP-HPLC method to detect and determine manool in this extract. The validation parameters were satisfactorily met and evaluated allows us to consider the developed method suitable for use in different labs. In conclusion, our results evidenced that the manool-rich S. officinalis extract can be considered an analytically validated alternative to develop novel and effective antimicrobial agents against the main bacteria responsible for dental caries.

https://doi.org/10.1590/S0102-695X2013000600003 2948 downloads

15.

Propagação in vitro de Hypericum cordatum (Vell.) N. Robson (Clusiaceae) e análise fitoquímica de seus compostos secundários
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Bianchi, B.R.

; Chu, E.P.

Revista Brasileira de Plantas Medicinais

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2013, Volume 15 Nº 1 Páginas 25 - 33

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Hypericum cordatum, planta com possível atividade medicinal foi analisada no presente estudo quanto a sua propagação in vitro e seus principais compostos secundários em comparação com Hypericum perforatum, espécie medicinal utilizada como antidepressivo. Diante das dificuldades que ocorrem na coleta e sua multiplicação por sementes ou via estacas caulinares, iniciou-se a propagação in vitro tendo como resultados: que a indução e o crescimento de brotações foram estimulados pelo regulador 6-benziladenina (2,0 mg L-1), que houve indução de raízes por ácido indol-butírico (0,5 mg L-1), e que as baixas concentrações de auxinas, ácido 2,4-diclorofenoxiacético, ou ácido naftalenoacético (0,01 a 0,4 mg L-1) induziram a formação de calos sendo uma alternativa viável para a multiplicação desta espécie in vitro. Constatou-se com base nas análises bioquímicas e cromatográficas realizadas nesta fase de desenvolvimento das plantas mantidas em culturas in vitro, que as mesmas não contêm hipericina. No entanto, pode-se atribuir o potencial medicinal de H. cordatum às outras substâncias que também possuem importantes atividades biológicas, tais como a xantona e o ácido clorogênico sintetizados nas glândulas foliares de H. cordatum.

Hypericum cordatum, a plant with possible medicinal activity, was analyzed in this study for its in vitro propagation and main secondary compounds, compared to Hypericum perforatum, a medicinal species used as antidepressant. Considering the difficulties that occur in its collection and multiplication through seeds or stem cuttings, in vitro propagation was started and showed the following results: the induction and the growth of sprouts were stimulated by the plant regulator 6-benzyladenine (2.0 mg L-1), there was root induction by indolebutyric acid (0.5 mg L-1) and the low concentrations of auxins, 2,4-dichlorophenoxyacetic acid or naphthaleneacetic acid (0.01 to 0.4 mg L-1) induced callus formation, constituting a viable alternative for the in vitro multiplication of this species. Biochemical and chromatographic analyses carried out at this developmental stage of plants kept in in vitro cultures indicated that they do not contain hypericin. However, the medicinal role of H. cordatum can be attributed to other substances that also have important biological activities, such as xanthone and chlorogenic acid, both synthesized in the leaf glands of H. cordatum.

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