ABSTRACT Enzyme replacement therapy (ERT) is a long term treatment for patients who suffer from lysosomal storage disease. A transversal descriptive study was conducted to evaluate advantages and disadvantages of a home-based care program for patients with Gaucher, Fabry and Mucopolysaccharidosis II (MPS II) diseases. A survey among patients and nurses involved in healthcare delivery at home was utilized for this study. The adherence rate was 92.9% over the study period. Eighty six point nine percent chose to carry out the treatment at home and 88.5% felt that their quality of life had improved. Additional advantages reported were: comfort (77%), treatment adjustment to daily activities (69%) and flexibility (58%). Disadvantages expressed were: lack of confidence with the health care provider at home (1.6%) and a shortage of disposable materials available (1.6%). The main benefits of home-based treatment were the high treatment adherence and the improvement in quality of life.

ABSTRACT Sporotrichosis is a subcutaneous mycosis caused by species of the group Sporothrix schenckii complex. Relatively frequent in Paraguay, in some cases it can be considered as a zoonosis. We present a family case of sporotrichosis, a father and his son who consulted in the Dermatology Service of the National Hospital, for skin lesions related to contact with a sick domestic cat, which presented lesions on the face. Clinically, the first case and a fixed plate corresponded to the lymphangitic form in the second. The diagnosis was confirmed with mycological culture. They received potassium iodide with a very good response after 5 months of treatment. The importance of this communication is to warn that the domestic cat suffering from and spreading sporotrichosis is important in the epidemiology of the disease, a situation observed in other regions.

RESUMEN La esporotricosis es una micosis subcutánea causada por especies del grupo Sporothrix schenckii complex. Relativamente frecuente en Paraguay, en algunos casos puede considerarse como una zoonosis. Se presenta un caso familiar de esporotricosis, un padre y su hijo que consultaron en el Servicio de Dermatología del Hospital Nacional, por lesiones en piel relacionadas al contacto con un gato doméstico enfermo, que presentaba lesiones en el rostro. Clínicamente correspondía a la forma linfangítica el primer caso y a placa fija en el segundo. El diagnóstico se confirmó con el cultivo micológico. Recibieron yoduro de potasio con muy buena respuesta luego de 5 meses de tratamiento. La importancia de esta comunicación es advertir que el gato doméstico al padecer y contagiar la esporotricosis, es importante en la epidemiología de la enfermedad, situación observada en otras regiones.