Pesquisa | SciELO

Abstract Background The use of the timed up and go (TUG) test to assess cardiorespiratory fitness in patients with heart disease has not been well defined in the literature. Objectives Test the association between TUG and peak oxygen consumption (VO2peak), construct an equation based on TUG to predict VO2peak, and determine a cutoff point to estimate VO2peak ≥ 20 mL/kg/min. Methods This cross-sectional study included 201 patients with coronary artery disease or heart failure, between 36 and 92 years of age, who underwent TUG and cardiopulmonary exercise test. Correlation, ROC curve, multiple linear regression, and Bland-Altman analyses were performed. The significance level was set at p < 0.05. Results The mean age of the total sample was 67 ± 13 years, and 70% of participants were male. The mean VO2peak was 17 ± 6 mL/kg/min, and the mean TUG time was 7 ± 2.5 seconds. The correlation between VO2peak and TUG was r = −0.54 (p < 0.001), and R2 was 0.30. The following equation was developed based on TUG: V O 2 peak = 33.553 + ( − 0.149 × age ) + ( − 0.738 × TUG ) + ( − 2.870 × sex ); a value of 0 was assigned to the male sex and 1 to the female sex (adjusted R: 0.41; adjusted R2: 0.40). The VO2peak estimated by the equation was 18.81 ± 3.2 mL/kg/min, and the VO2peak determined by cardiopulmonary exercise test was 18.18 ± 5.9 mL/kg/min (p > 0.05). The best cutoff point in the TUG for VO2peak ≥ 20 mL/kg/min was ≤ 5.47 seconds (area under the curve: 0.80; 95% confidence interval: 0.74 to 0.86). Conclusions TUG and VO2peak showed a significant association. A prediction equation for VO2peak was developed and validated internally with good performance. The cutoff point in the TUG to predict VO2peak ≥ 20 mL/kg/min was ≤ 5.47 seconds.

Resumo Fundamento A utilização do teste timed up and go (TUG) na avaliação da aptidão cardiorrespiratória em cardiopatas não está bem definida na literatura. Objetivos Testar a associação entre o TUG e o consumo de oxigênio de pico (VO2pico), construir uma equação com base no TUG para prever o VO2pico e determinar um ponto de corte para estimar um VO2pico ≥ 20 mL.kg−1.min−1. Métodos Estudo transversal com 201 indivíduos portadores de doença arterial coronariana ou insuficiência cardíaca, com idade entre 36 e 92 anos, submetidos ao TUG e ao teste cardiopulmonar de exercício. Foram realizadas análises de correlação, curva ROC, regressão linear múltipla e Bland-Altman. Um p < 0,05 foi adotado como significante. Resultados A média de idade da amostra total foi 67 ± 13 anos, e 70% dos participantes eram do sexo masculino. A média de VO2pico foi de 17 ± 6 mL.kg−1.min−1 e a média de desempenho no TUG foi de 7 ± 2,5 segundos. A correlação entre o VO2pico e o TUG foi r = −0,54 (p < 0,001) e R2 de 0,30. Foi desenvolvida a equação com base no TUG: V O 2 pico = 33 , 553 + ( − 0 , 149 ∗ idade ) + ( − 0 , 738 ∗ T U G ) + ( − 2 , 870 ∗ sexo ); sendo atribuído o valor 0 ao sexo masculino e 1 ao sexo feminino (R ajustado: 0,41; R2 ajustado: 0,40). O VO2pico estimado pela equação foi 18,81 ± 3,2 mL.kg−1.min−1 e o determinado pelo teste cardiopulmonar de exercício foi 18,18 ± 5,9 mL.kg−1.min−1 (p > 0,05). O melhor ponto de corte para o VO2pico ≥ 20 mL.kg−1.min−1 foi de ≤ 5,47 segundos (área sob a curva: 0,80; intervalo de confiança de 95%: 0,74 a 0,86). Conclusões O TUG e o VO2pico apresentaram associação significativa. A equação preditiva do VO2pico foi desenvolvida e validada internamente com bom desempenho. O ponto de corte no TUG para prever um VO2pico ≥ 20 mL.kg−1.min−1 foi ≤ 5,47 segundos.

https://doi.org/10.36660/abc.20230338

Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Landim, Caroline

; Dias, Cristiane Maria Carvalho Costa

; Nascimento, Celso

; Goes, Ana Lucia Barbosa

; Araújo, Thessika Hialla Almeida

; Ribeiro, Adriele

; Oliveira, Francisco Tiago de

; Castro-Lima, Humberto

; Boa-Sorte, Ney

; Galvão-Castro, Bernardo

Arquivos de Neuro-Psiquiatria

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Mar 2023, Volume 81 Nº 3 Páginas 271 - 283

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Flexibility is crucial to the harmonious execution of joint movements. While skeletal muscle dysfunction in patients with HTLV-1 can interfere with mobility, it is unclear whether these patients experience reduced flexibility. Objective To evaluate the differences in flexibility between HTLV-1-infected individuals with and without myelopathy compared with uninfected controls. We also investigated whether age, sex, body mass index (BMI), physical activity level, or lower back pain influence flexibility in HTLV-1-infected individuals. Methods The sample consisted of 56 adults, of which 15 did not have HTLV-1, 15 had HTLV-1 without myelopathy, and 26 had TSP/HAM. Their flexibility was assessed using the sit-and-reach test and a pendulum fleximeter. Results No differences in flexibility were observed between the groups with and without myelopathy and controls without HTLV-1 infection using the sit-and-reach test. The pendulum fleximeter results of individuals with TSP/HAM presented the lowest flexibility among the groups with respect to trunk flexion, hip flexion and extension, knee flexion, and ankle dorsiflexion, even after adjusting for age, sex, BMI, level of physical activity, and lower back pain using multiple linear regression models. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced flexibility in movements: knee flexion, dorsiflexion, and ankle plantar flexion. Conclusions Individuals with TSP/HAM demonstrated reduced flexibility in most of the movements evaluated by the pendulum fleximeter. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced knee and ankle flexibility, potentially representing a marker of myelopathic development.

Resumo Antecedentes A flexibilidade é fundamental para a execução harmoniosa dos movimentos articulares. Embora a disfunção do músculo esquelético em pacientes com HTLV-1 possa interferir na mobilidade, não está claro se esses pacientes apresentam flexibilidade reduzida. Objetivo Avaliar as diferenças de flexibilidade entre os indivíduos infectados com e sem mielopatia e o grupo controle sem infecção HTLV-1. Também investigamos se idade, sexo, índice de massa corporal (IMC), nível de atividade física ou dor lombar influenciam a flexibilidade em indivíduos infectados pelo HTLV-1. Métodos A amostra foi composta por 56 adultos, dos quais 15 não possuíam HTLV-1, 15 possuíam HTLV-1 sem mielopatia e 26 possuíam TSP/HAM. A flexibilidade foi avaliada por meio do teste de sentar e alcançar e do flexímetro de pêndulo. Resultados Não foram observadas diferenças na flexibilidade entre os grupos com e sem mielopatia no teste de sentar e alcançar. Os resultados do flexímetro pendular dos indivíduos com TSP/HAM apresentaram a menor flexibilidade entre os grupos em relação à flexão do tronco, flexão e extensão do quadril, flexão do joelho e dorsiflexão do tornozelo, mesmo após ajuste para idade, sexo, IMC, nível de atividade física e dor lombar usando modelos de regressão múltipla linear. Além disso, os indivíduos infectados pelo HTLV-1 sem mielopatia demonstraram redução da flexibilidade nos movimentos de flexão do joelho, dorsiflexão e flexão plantar do tornozelo. Conclusão Indivíduos com TSP/HAM demonstraram redução da flexibilidade na maioria dos movimentos avaliados pelo flexímetro pendular. Além disso, indivíduos infectados pelo HTLV-1 sem mielopatia demonstraram redução da flexibilidade do joelho e tornozelo, representando potencialmente um marcador de desenvolvimento mielopático.

https://doi.org/10.1055/s-0043-1764417

Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Araújo, Aurigena Antunes de

; Silva, Edna Maria

; Mafra, Cristiane Assunção da Costa Cunha

; Costa, Íris do Céu Clara

; Barbalho, Amanda Lanna Andrade

; Matos, Iolanda Augusta Fernandes de

; Santos, Matheus Araujo dos

; Lopes, Maria Luiza Diniz de Sousa

; Medeiros, Caroline Addison Carvalho Xavier de

; Soares, Luiz Alberto Lira

; Machado, Janaina Carla Barbosa

; Ferreira, Magda Rhayanny Assunção

; Araújo, Raimundo Fernandes de

; Nascimento, Rubens Maribondo do

; Guerra, Gerlane Coelho Bernardo

Brazilian Journal of Pharmaceutical Sciences

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2022, Volume 58 elocation e20114

Resumo: En | Texto: En | PDF: En

Abstract Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C. longa on 5-fluorouracil (5-FU)-induced oral mucositis (OM) in hamsters. Phytochemical analysis of crude C. longa extract (CLE) was performed to detect the presence of curcumin by TLC and HPLC. Golden Syrian hamsters were orally pre-treated with CLE (5, 50, or 100mg/kg). Cheek pouch samples were subjected to macroscopic and histopathological evaluation. ELISA was performed to quantify the inflammatory cytokines IL-1β and TNF-α. Superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels were assessed by ultraviolet-visible spectroscopy analysis. Behavior analysis was conducted by the open field test. Curcumin content in the CLE was 0.55%m/m ± 0.0161 (2.84%). The group treated with 5mg/kg CLE showed healing evidence with macroscopic absence of ulceration (p<0.05) and microscopic aspect of re-epithelialization, discrete inflammatory infiltrate and absence of edema. Treatment with 5mg/kg CLE significantly increased GSH levels, and reduced MDA levels and SOD activity (p˂0.05), and decreased IL-1β (p˂0.05) and TNF-α (p˂0.01) levels. A significant reduction in walking distance, ambulation, speed, and rearing was observed for motor activity. Curcumin reduced oxidative stress, inflammation, and motor activity in hamsters with 5-FU-induced OM.

https://doi.org/10.1590/s2175-97902022000xe20114

Anatomo-Histological Evaluation of Male Reproductive System of the Juvenile Caiman crocodilus yacare
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics

Takamine, Cristiane Naoko

; Carvalho, Hianka Jasmyne Costa de

; Araújo, Michelle Silva

; Ribeiro, Rafaela Rodrigues

; Miglino, Maria Angélica

; de-Melo, Alan Peres Ferraz

International Journal of Morphology

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Dez 2021, Volume 39 Nº 6 Páginas 1688 - 1693

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

SUMMARY: The Caiman crocodilus yacare was once close to extinction. Studies about the male reproductive tract may aid in their reproduction and conservation. In this work, after sedation and euthanasia, seven young male C. yacare were submitted to necropsy, and macroscopic evaluation of the reproductive system, while the three others were admitted for histological study. The histological sections were stained with Hematoxylin & Eosin and Masson's Trichrome. After opening the pleuroperitoneal cavity it was possible to identify that the testicles were disposed in pairs and attached to its dorsal surface. The epididymis showed elongated and convoluted shapes and were located at the cranial margin of the testicles, following its medial portion, which was the same portion that the “vas deferens” stems from until the opening of the cloaca. The crocodile phallus presented a tubular shape, with conical appearance, displaying little resistance while maintaining its flexibility, compatible with a fibrocartilaginous tissue. On light microscopic analysis it was possible to observe that the testis was delimited by the tunica albuginea. The seminiferous tubules were contorted, and the interstitial space was filled with interstitial tissue and Leydig cells. The epididymal ductus were covered with non-ciliated pseudostratified epithelium with cells varying between cuboidal and prismatic shapes. The ductus deferens were characterized by a narrow girth shrouded with non- ciliated pseudostratified prismatic epithelium. The phallus of the crocodile was covered with a non-keratinized squamous epithelium surrounded by connective tissue. The findings support anatomic and histologic knowledge Alligatoridae reproductive system, enabling further research in the C. yacare reproduction and conservation.

RESUMEN: El Caiman crocodilus yacare ha estado en peligro de extinción. Los estudios sobre el aparato reproductor del macho pueden ser de ayuda en su reproducción y conservación. En este trabajo, fueron sometidos a necropsia y evaluación macroscópica del aparato reproductor, siete machos jóvenes de C. yacare, mientras que otros tres fueron utilizados para su estudio histológico. Las secciones histológicas se tiñeron con hematoxilina y eosina y tricrómico de Masson. Después de examinar la cavidad pleuroperitoneal se pudo identificar que los testículos estaban dispuestos en pares y adheridos a su superficie dorsal. El epidídimo presentaba formas alargadas y contorneadas y se ubicaba en el margen craneal de los testículos, siguiendo su porción medial, que era la misma porción de donde parten los conductos deferentes hasta la apertura de la cloaca. El pene del cocodrilo presentaba forma tubular, de apariencia cónica, mostrando poca resistencia manteniendo su flexibilidad, compatible con un tejido fibrocartilaginoso. En el análisis microscópico óptico se pudo observar que el testículo estaba delimitado por la túnica albugínea. Los túbulos seminíferos estaban contorsionados y el espacio intersticial estaba lleno de tejido intersticial y células intersticiales (células de Leydig). El epidídimo estaba cubierto con epitelio pseudoestratificado no ciliado con células que variaban entre formas cuboideas y prismáticas. Los conductos deferentes se caracterizaron por una circunferencia estrecha envuelta en un epitelio prismático pseudoestratificado no ciliado. El pene del cocodrilo estaba cubierto con un epitelio escamoso no queratinizado rodeado de tejido conectivo. Los hallazgos corroboran el conocimiento de la anatomía del sistema reproductivo de Alligatoridae, lo que permite una mayor investigación sobre la reproducción y conservación de C. yacare.

185 downloads

Posicionamento Brasileiro sobre o Uso da Multimodalidade de Imagens na Cardio-Oncologia – 2021
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Melo, Marcelo Dantas Tavares de

; Paiva, Marcelo Goulart

; Santos, Maria Verônica Câmara

; Rochitte, Carlos Eduardo

; Moreira, Valéria de Melo

; Saleh, Mohamed Hassan

; Brandão, Simone Cristina Soares

; Gallafrio, Claudia Cosentino

; Goldwasser, Daniel

; Gripp, Eliza de Almeida

; Piveta, Rafael Bonafim

; Silva, Tonnison Oliveira

; Santo, Thais Harada Campos Espirito

; Ferreira, Waldinai Pereira

; Salemi, Vera Maria Cury

; Cauduro, Sanderson A.

; Barberato, Silvio Henrique

; Lopes, Heloísa M. Christovam

; Pena, José Luiz Barros

; Rached, Heron Rhydan Saad

; Miglioranza, Marcelo Haertel

; Pinheiro, Aurélio Carvalho

; Vrandecic, Bárbara Athayde Linhares Martins

; Cruz, Cecilia Beatriz Bittencourt Viana

; Nomura, César Higa

; Cerbino, Fernanda Mello Erthal

; Costa, Isabela Bispo Santos da Silva

; Coelho Filho, Otavio Rizzi

; Carneiro, Adriano Camargo de Castro

; Burgos, Ursula Maria Moreira Costa

; Fernandes, Juliano Lara

; Uellendahl, Marly

; Calado, Eveline Barros

; Senra, Tiago

; Assunção, Bruna Leal

; Freire, Claudia Maria Vilas

; Martins, Cristiane Nunes

; Sawamura, Karen Saori Shiraishi

; Brito, Márcio Miranda

; Jardim, Maria Fernanda Silva

; Bernardes, Renata Junqueira Moll

; Diógenes, Tereza Cristina

; Vieira, Lucas de Oliveira

; Mesquita, Claudio Tinoco

; Lopes, Rafael Willain

; Segundo Neto, Elry Medeiros Vieira

; Rigo, Letícia

; Marin, Valeska Leite Siqueira

; Santos, Marcelo José

; Grossman, Gabriel Blacher

; Quagliato, Priscila Cestari

; Alcantara, Monica Luiza de

; Teodoro, José Aldo Ribeiro

; Albricker, Ana Cristina Lopes

; Barros, Fanilda Souto

; Amaral, Salomon Israel do

; Porto, Carmen Lúcia Lascasas

; Barros, Marcio Vinícius Lins

; Santos, Simone Nascimento dos

; Cantisano, Armando Luís

; Petisco, Ana Cláudia Gomes Pereira

; Barbosa, José Eduardo Martins

; Veloso, Orlando Carlos Glória

; Spina, Salvador

; Pignatelli, Ricardo

; Hajjar, Ludhmilla Abrahão

; Kalil Filho, Roberto

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Vieira, Marcelo Luiz Campos

; Almeida, André Luiz Cerqueira

Arquivos Brasileiros de Cardiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Out 2021, Volume 117 Nº 4 Páginas 845 - 909

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200266 103 downloads

Diretrizes Brasileiras de Hipertensão Arterial – 2020
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Barroso, Weimar Kunz Sebba

; Rodrigues, Cibele Isaac Saad

; Bortolotto, Luiz Aparecido

; Mota-Gomes, Marco Antônio

; Brandão, Andréa Araujo

; Feitosa, Audes Diógenes de Magalhães

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Amodeo, Celso

; Mion Júnior, Décio

; Barbosa, Eduardo Costa Duarte

; Nobre, Fernando

; Guimarães, Isabel Cristina Britto

; Vilela-Martin, José Fernando

; Yugar-Toledo, Juan Carlos

; Magalhães, Maria Eliane Campos

; Neves, Mário Fritsch Toros

; Jardim, Paulo César Brandão Veiga

; Miranda, Roberto Dischinger

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C

; Alessi, Alexandre

; Lucena, Alexandre Jorge Gomes de

; Avezum, Alvaro

; Sousa, Ana Luiza Lima

; Pio-Abreu, Andrea

; Sposito, Andrei Carvalho

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Nogueira, Armando da Rocha

; Dinamarco, Nelson

; Eibel, Bruna

; Forjaz, Cláudia Lúcia de Moraes

; Zanini, Claudia Regina de Oliveira

; Souza, Cristiane Bueno de

; Souza, Dilma do Socorro Moraes de

; Nilson, Eduardo Augusto Fernandes

; Costa, Elisa Franco de Assis

; Freitas, Elizabete Viana de

; Duarte, Elizabeth da Rosa

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Cesarino, Evandro José

; Marques, Fabiana

; Argenta, Fábio

; Consolim-Colombo, Fernanda Marciano

; Baptista, Fernanda Spadotto

; Almeida, Fernando Antonio de

; Borelli, Flávio Antonio de Oliveira

; Fuchs, Flávio Danni

; Plavnik, Frida Liane

; Salles, Gil Fernando

; Feitosa, Gilson Soares

; Silva, Giovanio Vieira da

; Guerra, Grazia Maria

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Back, Isabela de Carlos

; Oliveira Filho, João Bosco de

; Gemelli, João Roberto

; Mill, José Geraldo

; Ribeiro, José Marcio

; Lotaif, Leda A. Daud

; Costa, Lilian Soares da

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano Ferreira

; Martin, Luis Cuadrado

; Scala, Luiz César Nazário

; Almeida, Madson Q.

; Gowdak, Marcia Maria Godoy

; Klein, Marcia Regina Simas Torres

; Malachias, Marcus Vinícius Bolívar

; Kuschnir, Maria Cristina Caetano

; Pinheiro, Maria Eliete

; Borba, Mario Henrique Elesbão de

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Coelho, Otavio Rizzi

; Vitorino, Priscila Valverde de Oliveira

; Ribeiro Junior, Renault Mattos

; Esporcatte, Roberto

; Franco, Roberto

; Pedrosa, Rodrigo

; Mulinari, Rogerio Andrade

; Paula, Rogério Baumgratz de

; Okawa, Rogério Toshiro Passos

; Rosa, Ronaldo Fernandes

; Amaral, Sandra Lia do

; Ferreira-Filho, Sebastião R.

; Kaiser, Sergio Emanuel

; Jardim, Thiago de Souza Veiga

; Guimarães, Vanildo

; Koch, Vera H.

; Oigman, Wille

; Nadruz, Wilson

Arquivos Brasileiros de Cardiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Mar 2021, Volume 116 Nº 3 Páginas 516 - 658

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201238 10948 downloads

Parents' Emotional and Social Experiences of Caring a Child with Cleft Lip and/or Palate
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Carvalho, Naiara Oliveira

; Matos, Maria Franciele Soares

; Belchior, Iara Freire Costa

; Araújo, Marcos Bruno

; Rocha, Cristiane Tomaz

; Neves, Beatriz Gonçalves

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2021, Volume 21 elocation e0168

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To evaluate the emotional and social experiences of parents or caregivers of children with cleft lip and/or palate (CL/P) in a city in the Northeastern of Brazil. Material and Methods: A quantitative and cross-sectional study was conducted among parents or caregivers of children with CL/P by interviews based on a questionnaire. Interviews were conducted during the First Smile Project in Sobral, Ceará, Brazil. All participants (n=41) agreed to participate in the interview and signed an informed consent. The data was analyzed in SPSS software version 22.0. Results: The majority of participants were female (87.2%), with a mean age of 37 years, with a low level of education and low family income. The great majority (90.2%) of the parents were not prenatally diagnosed to have CL/P babies. Of those interviewed, 56.1% mentioned that the first diagnosis of cleft lip and palate was not presented by the professionals in a clarifying way to the family. Fear (36.6%) and sadness (19.5%) were the main feelings experienced when the child was diagnosed with fissure. Feeding (48.8%) was pointed out as the main concern in caring for a child with CL/P. Conclusion: The parents and caregivers interviewed faced important emotional and social problems that must be addressed by the professional team that assists the child with CL/P.

https://doi.org/10.1590/pboci.2021.058 139 downloads

In vitro anthelmintic activity of Lippia gracilis Schauer essential oil against egg-hatching of goat gastrointestinal nematodes
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Souza, Anna Lopes da Costa

; Rebouças, Cristina Karine de Oliveira

; Albuquerque, Cynthia Cavalcanti de

; Moura, Cristiane de Carvalho Ferreira Lima

; Torres, Taffarel Melo

; Batista, João Inácio Lopes

; Bezerra, Francisco Silvestre Brilhante

; Bezerra, Ana Carla Diógenes Suassuna

Arquivos do Instituto Biológico

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2020, Volume 87 elocation e0522019

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Como os nematoides resistentes a drogas se tornaram um problema comum nas indústrias de ovinos e caprinos, métodos alternativos que utilizam produtos naturais surgiram como uma opção de tratamento anti-helmíntico viável e sustentável. Aqui, o efeito in vitro do óleo essencial extraído de Lippia gracilis Schauer foi avaliado no processo de eclosão de nematoides recuperados de caprinos naturalmente infectadas. O óleo essencial nas concentrações de 0,08% (0,008 μL/mL), 0,12% (0,012 μL/mL), e 0,16% (0,016 μL/mL)foi capaz de induzir uma inibição média de 74,7, 84 e 93%, respectivamente. A concentração efetiva necessária para inibir a eclosão de ovos em 50% dos ovos (CE50) foi de 0,03452%. Portanto, o óleo essencial de L. gracilis apresentou resultados anti-helmínticos in vitro promissores contra a eclosão de nematódeos gastrintestinais de caprinos.

ABSTRACT Since drug-resistant nematodes became a common problem in sheep and goat industries, alternative methods using natural products have emerged as a viable and sustainable anthelmintic treatment option. Here, the in vitro effect of essential oil extracted from Lippia gracilis Schauer was assessed on the hatching process of nematodes recovered from naturally infected goats. Essential oil at concentrations of 0.08% (0.008 μL/mL), 0.12% (0.012 μL/mL), and 0.16% (0.016 μL/mL) was able to induce an average inhibition of 74.7, 84 and 93%, respectively. The effective concentration required to inhibit egg hatching in 50% of eggs (EC50) was 0.03452%. Therefore, essential oil of L. gracilis showed promisor in vitro anthelmintic results against egg-hatching of goat gastrointestinal nematodes.

https://doi.org/10.1590/1808-1657000522019 479 downloads

Mammary adenectomy followed by immediate reconstruction for treatment of patients with early-infiltrating breast carcinoma: a cohort study
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Barros, Alfredo Carlos Simões Dornellas de

; Carvalho, Heloísa Andrade

; Andrade, Felipe Eduardo Martins

; Nimir, Cristiane da Costa Bandeira Abrahão

; Sampaio, Marcelo Moura Costa

; Makdissi, Fabiana Baroni

; Mano, Max Senna

Sao Paulo Medical Journal

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Jul 2019, Volume 137 Nº 4 Páginas 336 - 342

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Use of mammary adenectomy for breast carcinoma treatment remains controversial. OBJECTIVE: This study aimed to verify the oncological safety of mammary adenectomy and immediate breast reconstruction for treating selected patients with infiltrating breast carcinoma and to evaluate patients’ satisfaction with the reconstructed breasts. DESIGN AND SETTING: Cohort study conducted among patients treated at Hospital Sírio-Libanês, São Paulo, Brazil. METHODS: This study was based on 152 selected patients (161 operated breasts) with infiltrating breast carcinoma who underwent mammary adenectomy and immediate breast reconstruction. In all patients, the diameter of the largest focus of the tumor was less than 3.0 cm, the imaging tumor-nipple distance was greater than 2.0 cm and the pathological assessment showed clear margins. The cumulative incidence of local recurrence (LR), recurrence-free survival (RFS) and overall survival (OS) curves were estimated using the Kaplan-Meier method. After at least one year of follow-up, 64 patients were asked about their satisfaction with the reconstructed breast(s). RESULTS: At a mean follow-up time of 43.5 months, seven cases of LR (4.4%), four distant metastases (2.6%) and five deaths (3.3%) were recorded. The five-year actuarial LR-free survival, RFS and OS were 97.6%, 98.3% and 98.3%, respectively. No cases of nipple-areolar complex recurrence were reported. Forty-one patients (64%) indicated a high level of satisfaction with the reconstructed breasts. CONCLUSIONS: Mammary adenectomy is a safe and efficacious procedure for selected patients with early-infiltrating breast carcinoma and results in a high rate of patient satisfaction with the reconstructed breasts.

https://doi.org/10.1590/1516-3180.2018.0356220719 957 downloads

10.

Carbon emissions associated with two types of foundations: CP-II Portland cement-based composite vs. geopolymer concrete
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Gomes, Kelly Cristiane

; Carvalho, Monica

; Diniz, Daniel de Paula

; Abrantes, Rafael de Carvalho Costa

; Branco, Michel Alves

; Carvalho Junior, Paulo Roberto Oliveira de

Matéria (Rio de Janeiro)

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2019, Volume 24 Nº 4 elocation e12525

Resumo: En | Texto: En | PDF: En

ABSTRACT The cement industry is the second-largest single industrial emitter in the world and therefore has an important role to play in reducing the intensity of its carbon emissions: participation of the sector is important to contribute to the goal of the Paris Climate Change Agreement to limit global warming. One of the strategies for reducing the carbon footprint of the cement industry is substitution of Portland cement, which is a component of the concrete mix widely used as a construction material worldwide. Geopolymer cement has emerged as an alternative for Portland cement, with several advantages. This study applied the Life Cycle Assessment methodology to quantify the carbon emissions associated with 1m3 of two types of concrete (concrete PC-II cement-based Portland cement vs. geopolymer concrete). Geopolymer concrete presented almost 43% less carbon emissions, while also presenting high physic-chemical performance. It was verified that geopolymer concrete has the potential to help mitigate climate change, and can be employed as part of the plan to minimize the emissions associated with the construction sector.

https://doi.org/10.1590/s1517-707620190004.0850 1609 downloads

11.

The impact of a biomanipulation experiment on the ichthyofauna diet from a neotropical reservoir in Brazilian semiarid
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Moura, Cristiane de Carvalho Ferreira Lima

; Oliveira, Jônnata Fernandes

; Novaes, José Luís Costa

; Costa, Rodrigo Silva da

; Araújo, Darlan Dantas Alves de

; Peretti, Danielle

Acta Limnologica Brasiliensia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2018, Volume 30 elocation e107

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar o impacto de um experimento de biomanipulação na alimentação das espécies da ictiofauna de um reservatório do semiárido neotropical, antes e após a remoção da espécie exótica Oreochromis niloticus. Métodos Os dados foram amostrados em dois períodos, antes da remoção da espécie (maio de 2012 a janeiro de 2013) e após a remoção (abril de 2013 a novembro de 2013). Foram analisadas os valores do Índice Alimentar de seis espécies: Oreochromis niloticus, Prochilodus brevis Steindachner,1875, Hypostomus cf. paparie Fowler,1941, Hoplias gr. malabaricus Bloch,1794, Astyanax bimaculatus Linnaeus,1758 e Leporinus piau Fowler,194. O índice de Morisita-Horn foi usado para avaliar a similaridade alimentar entre as espécies e estabelecer categorias tróficas (insetívora, onívora, detritívora/iliófaga e piscívora). Para avaliar as possíveis variações devido à presença da espécie O. niloticus, foi utilizado o Índice Alimentar das espécies numa matriz de similaridade de Bray-Curtis, usando a análise de ordenação (NMDS), a Análise de Correspondência Canônica (CCA) avaliou se houve influência das variáveis ambientais na dieta, a partir dos dados do Índice Alimentar. Resultados As espécies foram enquadradas em quatro categorias tróficas que não demonstraram variação nos grupos formados entre os períodos estudados. Após a remoção da tilápia algumas espécies apresentaram mudanças em itens alimentares, segundo a análise de ordenação (NMDS). A Análise de Correspondência Canônica indicou uma baixa associação entre os dados do Índice Alimentar mensal das espécies e as variáveis ambientais. Conclusão O processo de biomanipulação no reservatório da Estação Ecológica de Serra Negra, visando comparar as dietas de cinco espécies nativas antes e após a remoção da espécie exótica Oreochromis niloticus, resultou em alteração na composição da dieta de três das cinco espécies estudadas.

Abstract Aim To evaluate the impact of a biomanipulation experiment on the feeding of fish species from a neotropical semiarid reservoir, before and after the removal of the exotic species Oreochromis niloticus. Methods The values of Food Index were analyzed for six species: Oreochromis niloticus , Prochilodus brevis Steindachner,1875, Hypostomus cf. paparie Fowler,1941, Hoplias gr. malabaricus Bloch,1794, Astyanax bimaculatus Linnaeus,1758 and Leporinus piau Fowler,194. All data were obtained in two periods, before of the removal O. niloticus (May 2012 to January 2013) and after its removal (April 2013 to November 2013). The Morisita-Horn index was used to evaluate the feeding similarity among the six species and determine trophic categories (insectivorous, omnivorous, iliophaga and piscivora). To establish the probable variations due the presence of O. niloticus species, the Food Index of the six species was used in a Bray-Curtis similarity matrix. Through the Non-metric Multidimensional Scaling (NMDS) we could not observe any differences among items consumed by different species. The Canonical Correspondence Analysis (CCA) was used to assay the influence of environmental variables on the dietary, from the Food Index data. Results All species were classified in four trophic categories that do not shown any variation among the formed groups during studied periods. After the removal of Nile tilapia some species showed changes in food items, according to NMDS. The CCA indicated low association among the monthly Food Index of species and the environmental changes. Conclusion The process of biomanipulation on the Ecological Station from Serra Negra reservoir, which compares the dietaries from five local species before and after removal of exotic species Oreochromis niloticus, resulted in modification of dietary composition from three of five studied species.

https://doi.org/10.1590/s2179-975x2817 1611 downloads

12.

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Cavalcante, José Roosevelt

; Pinheiro, Luiz Gonzaga Porto

; Almeida, Paulo Roberto Carvalho de

; Ferreira, Márcia Valéria Pitombeira

; Cruz, Gizele Almada

; Campelo, Thales Alves

; Silva, Caroliny Soares

; Lima, Luana Nepomuceno Gondim Costa

; Oliveira, Bruno Masato Kitagawa de

; Lima, Lara Mulato

; Feitosa, Laura Magda Costa

; Pinheiro, Agostinho Câmara

; Frota, Cristiane Cunha

Clinics

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2018, Volume 73 elocation e465

Resumo: En | Texto: En | PDF: En

OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. RESULTS: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. CONCLUSIONS: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.

https://doi.org/10.6061/clinics/2018/e465 897 downloads

13.

Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Faludi, André Arpad

; Izar, Maria Cristina de Oliveira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula Marte

; Bianco, Henrique Tria

; Afiune Neto, Abrahão

; Bertolami, Adriana

; Pereira, Alexandre C.

; Lottenberg, Ana Maria

; Sposito, Andrei C.

; Chagas, Antonio Carlos Palandri

; Casella Filho, Antonio

; Simão, Antônio Felipe

; Alencar Filho, Aristóteles Comte de

; Caramelli, Bruno

; Magalhães, Carlos Costa

; Negrão, Carlos Eduardo

; Ferreira, Carlos Eduardo dos Santos

; Scherr, Carlos

; Feio, Claudine Maria Alves

; Kovacs, Cristiane

; Araújo, Daniel Branco de

; Magnoni, Daniel

; Calderaro, Daniela

; Gualandro, Danielle Menosi

; Mello Junior, Edgard Pessoa de

; Alexandre, Elizabeth Regina Giunco

; Sato, Emília Inoue

; Moriguchi, Emilio Hideyuki

; Rached, Fabiana Hanna

; Santos, Fábio César dos

; Cesena, Fernando Henpin Yue

; Fonseca, Francisco Antonio Helfenstein

; Fonseca, Henrique Andrade Rodrigues da

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Issa, Jaqueline Scholz

; Diament, Jayme

; Pesquero, João Bosco

; Santos, José Ernesto dos

; Faria Neto, José Rocha

; Melo Filho, José Xavier de

; Kato, Juliana Tieko

; Torres, Kerginaldo Paulo

; Bertolami, Marcelo Chiara

; Assad, Marcelo Heitor Vieira

; Miname, Márcio Hiroshi

; Scartezini, Marileia

; Forti, Neusa Assumpta

; Coelho, Otávio Rizzi

; Maranhão, Raul Cavalcante

; Santos Filho, Raul Dias dos

; Alves, Renato Jorge

; Cassani, Roberta Lara

; Betti, Roberto Tadeu Barcellos

; Carvalho, Tales de

; Martinez, Tânia Leme da Rocha

; Giraldez, Viviane Zorzanelli Rocha

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Ago 2017, Volume 109 Nº 2 Páginas 1 - 76

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.5935/abc.20170121 199102 downloads

14.

Utilização de biomarcadores de genotoxicidade e expressão gênica na avaliação de trabalhadores de postos de combustíveis expostos a vapores de gasolina
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Valente, Daniel

; Costa-Amaral, Isabele Campos

; Carvalho, Leandro Vargas Barreto de

; Santos, Marcus Vinicius Corrêa dos

; Castro, Vinicio Soares de

; Rodrigues, Daniela del Rosário Flores

; Falco, Anna De

; Silva, Cristiane Barata

; Nogueira, Simone Mitri

; Gonçalves, Eline Simões

; Moreira, Josino Costa

; André, Leiliane Coelho

; Teixeira, Liliane Reis

; Sarcinelli, Paula de Novaes

; Sisenando, Herbert Ary

; Oliveira, Monica Stuck de

; Perini, Jamila Alessandra

; Mattos, Rita de Cássia Oliveira da Costa

; Larentis, Ariane Leites

Revista Brasileira de Saúde Ocupacional

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2017, Volume 42 Supl. 1 elocation e2s

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: a avaliação de uma exposição mensura sua intensidade, frequência e duração, podendo detectar danos precoces que, se ignorados, podem evoluir para um quadro nocivo. Nos campos da saúde ambiental e ocupacional, os biomarcadores de genotoxicidade tem sido largamente utilizados para essa avaliação. Objetivo: identificar, descrever e discutir os principais bioindicadores de genotoxicidade e seu uso conjunto com técnicas de avaliação de expressão gênica em estudos de exposição ocupacional ao benzeno em postos de revenda de combustíveis (PRC). Métodos: revisão bibliográfica de trabalhos publicados entre 1995 e 2015. Resultados: as técnicas identificadas foram: ensaio cometa, estresse oxidativo, micronúcleos, aberrações cromossômicas, polimorfismos, adutos de DNA e proteínas, fatores epigenéticos e expressão gênica. Foi observado que testes de danos genéticos e epigenéticos são utilizados em frentistas de PRC que participam de programas de saúde do trabalhador ou de pesquisas, embora um baixo número de publicações sobre o tema tenha sido identificado. Esse fato talvez possa ser explicado pelos poucos países onde a profissão persiste e pelas limitações para o desenvolvimento de pesquisas nesses países. Conclusão: os bioindicadores de genotoxicidade e as técnicas de expressão gênica são úteis na detecção de dano precoce desta exposição ocupacional e devem ser avaliados em conjunto.

Abstract Introduction: an exposure evaluation measures its intensity, frequencyand duration, detecting premature damage that, if ignored, might develop into a harmful framework. On environmental and occupational health fields, genotoxicity biomarkers have been widely used for this evaluation. Objective: to identify, describe and discuss main genotoxicity biomarkers and their use together with gene expression evaluation techniques in studies concerning occupational exposure to benzene in gas stations (GS). Methods: bibliographical review of studies published between 1995 and 2015. Results: the following techniques were identified: comet assay, oxidative stress, micronuclei, chromosomal aberrations, polymorphisms, DNA and protein adducts, epigenetic factors and gene expression. We observed that genetic and epigenetic damage tests are used in gas station attendants who participate in worker’s health programs or in researches, although a short number of publications on the theme have been identified. This can be explained by the small number of countries where such job still exists and by the limitations for developing research in such countries. Conclusion: genotoxicity biomarkers and gene expression techniques are useful for detecting the premature damage resulting from this occupational exposure and must be jointly evaluated.

https://doi.org/10.1590/2317-6369000124415 9255 downloads

15.

Quality of life and pain multidimensional aspects in individuals with HTLV-1
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Macêdo, Maíra Carvalho

; Mota, Renata de Sousa

; Patrício, Naiane Araújo

; Santos, Ana Paula Campos dos

; Mendes, Selena Márcia Dubois

; Dias, Cristiane Maria Carvalho Costa

; Baptista, Abrahão Fontes

; Sá, Katia Nunes

Brazilian Journal of Infectious Diseases

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Out 2016, Volume 20 Nº 5 Páginas 494 - 498

Resumo: En | Texto: En | PDF: En

Abstract HTLV-1 creates a chronic health condition that involves moderate to severe pain with a negative impact on quality of life (QoL). There is no consensus on which attitudes to pain are more related to the worsening of QoL in HTLV-1 infected patients. The aim of this study was to investigate the correlation between QoL and multidimensional aspects of pain in patients with HTLV-1. A cross-sectional study was conducted in Salvador, Bahia, Brazil. The study included individuals diagnosed with HTLV-1. The Short Form 36 Questionnaire was used to analyze QoL, and the Brief Pain Inventory was used to assess multidimensional aspects of pain. The mean pain intensity was 4.88 ± 3.06 on the visual pain scale, and the average impact on QoL corresponded to a loss of approximately 40%. Moderate to high correlations between pain intensity and all domains of QoL were observed and compared reaction attitudes for general activity, mood, ability to walk, ability to work, relationships, sleep, and ability to enjoy life (r > 0.40; p < 0.05). Moderate correlations were found between all domains of QoL, pain intensity, and reactive attitudes to pain. The greatest pain intensity impacts involved difficulty to walk and to work, and interpersonal relationships in the emotional aspect of QoL.

https://doi.org/10.1016/j.bjid.2016.05.010 869 downloads

Exibindo

itens por página

Página de 3 Próxima

Selecione um ou mais resultados

Todos Ordem alfabética

Resultados

Gráfico comparativo Download CSV

Visualizar estatísticas de

Enviar resultado

E-mail do(s) destinatários*

Utilize ; (ponto e vírgula) para mais de um e-mail.

Enviar por e-mail

Esta página

Registros selecionados

Todos os registros (max. 300)

Alterar remetente, assunto e comentários

Seu email

Assunto

Comentários

Alterar remetente, assunto e comentários

Exportar resultados

Formato de exportação:

RIS (para EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citação

CSV (para Excel, etc)

Exportar:

Esta página

Itens selecionados

Todos os registros (max. 2000)

Mostrar mais

Sem resultados

Não foram encontrados documentos para sua pesquisa

Glossário e ajuda para busca

Você pode enriquecer sua busca de uma forma muito simples. Use os índices de pesquisa combinados com os conectores (AND ou OR) e especifique cada vez mais sua busca.

Por exemplo, se você deseja buscar artigos sobre
casos de dengue no Brasil em 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

Veja abaixo a lista completa de índices de pesquisa que podem ser usados:

Cód. do Índice	Elemento
ti	título do artigo
au	autor
kw	palavras-chave do artigo
subject	assunto (palavras do título, resumo e palavras-chave)
ab	resumo
ta	título abreviado da revista (ex. Cad. Saúde Pública)
journal_title	título completo da revista (ex. Cadernos de Saúde Pública)
la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

Todo o conteúdo de www.scielo.org, exceto onde está identificado, está licenciado sob uma Licença Creative Commons.
saiba mais »