Pesquisa | SciELO

Resumo O conteúdo de dopamina nas estruturas cerebrais tem sido relacionado à excitabilidade neuronal e várias abordagens têm sido utilizadas para estudar este fenômeno durante o período de vulnerabilidade às crises. No presente trabalho, descrevemos os efeitos da depleção de dopamina após a administração de 6-hidroxidopamina (6-OHDA) na região pars compacta da substância negra de ratos submetidos ao modelo de epilepsia com pilocarpina. A susceptibilidade ao estado de mal epiléptico induzido pela pilocarpina, bem como a frequência de crises espontâneas e recorrentes durante o período crônico do modelo foi determinada. Sendo o hipocampo uma das principais estruturas afetadas no desenvolvimento desse modelo experimental de epilepsia, os níveis de dopamina nessa região foram determinados após a administração da droga. No primeiro experimento, 62% (15/24) dos ratos pré-tratados com 6-OHDA e 45% (11/24) daqueles que receberam ácido ascórbico como solução controle evoluíram para crises límbicas motoras e para o estado de mal epiléptico, após a administração de pilocarpina. A gravidade das crises durante o período agudo do modelo foi significativamente maior nos ratos epilépticos experimentais (56,52%) do que nos ratos controle (4,16%). No segundo experimento, não houve diferença significante entre os grupos quanto à frequência de crises na fase crônica do modelo. Nossos dados mostraram que a dopamina pode desempenhar um papel importante na gravidade das crises na fase aguda da pilo, o que parece ser exercido por sua ação inibitória da dopamina sobre a expressão motora das crises.

Abstract The dopamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability period. In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. Since the hippocampus is one of main structures in the development of this experimental model of epilepsy, the dopamine levels in this region were also determined after drug administration. In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. Severeness of seizures during the model´s the acute period, was significantly higher in epileptic experimental rats (56.52%), than in controls (4.16%). In the second experiment, the frequency of seizures in the model’s chronic phase did not significantly change between groups. Our data show that dopamine may play an important role on seizure severity in the pilo’s model acute period, which seems to be due to dopamine inhibitory action on motor expression of seizure.

https://doi.org/10.1590/1519-6984.248411

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
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Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

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Out 2023, Volume 49 Nº 5 Páginas 580 - 589

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida
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Barbosa, D. H. X.

; Gondim, C. R.

; Silva-Henriques, M. Q.

; Soares, C. S.

; Alves, D. N.

; Santos, S. G.

; Castro, R. D.

Brazilian Journal of Biology

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2023, Volume 83 elocation e264875

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study aimed to analyze the phytochemical profile of essential oil obtained from the leaves of Coriandrum sativum L., and its antifungal activity against Candida spp. The research consisted of an in vitro study including collecting the vegetable product, analysis of its macronutrients, extraction, and chemical analysis of the essential oil, and assaying antifungal activity through minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), with growth inhibition kinetics, and the product’s effects on multi-species Candida biofilm. Nitrogen (47.08 g Kg-1), phosphorus (5.3 g Kg-1) and potassium (50.46 g Kg-1) levels were within the normal range. The major constituents were octanal, decanal, dec-(2E)-enal, and dodecanal. The MIC and MFC of the product evaluated against 11 tested Candida strains ranged from 31.25 to 250 μg/mL. There was inhibition of fungal growth during 24 hours of exposure at the 3 concentrations tested (250, 125, and 62.5 μg/mL). The concentration of 80 mg/mL promoted the greatest reduction in multispecies biofilm (70% reduction in biofilm). Coriandrum sativum L. essential oil extract is principally constituted of alcohols and aldehydes and presents fungicidal activity against Candida spp. in its in planktonic and biofilm forms.

Resumo Este trabalho teve como objetivo analisar o perfil fitoquímico do óleo essencial obtido das folhas de Coriandrum sativum L., e sua atividade antifúngica contra Candida spp. A pesquisa consistiu em um estudo in vitro incluindo a coleta do produto vegetal, análise de seus macronutrientes, extração e análise química do óleo essencial e ensaio da atividade antifúngica por meio da concentração inibitória mínima (CIM) e concentração fungicida mínima (MFC), com crescimento cinética de inibição e os efeitos do produto no biofilme de Candida multi-espécies. Os níveis de nitrogênio (47,08 g Kg-1), fósforo (5,3 g Kg-1) e potássio (50,46 g Kg-1) estavam dentro da normalidade. Os principais constituintes foram octanal, decanal, dec-(2E)-enal e dodecanal. A CIM e CFM do produto avaliado contra 11 cepas de Candida testadas variaram de 31,25 a 250 μg/mL. Houve inibição do crescimento fúngico durante 24 horas de exposição nas 3 concentrações testadas (250, 125 e 62,5 μg/mL). A concentração de 80 mg/mL promoveu a maior redução no biofilme multiespécies (redução de 70% no biofilme). O extrato do óleo essencial de Coriandrum sativum L. é constituído principalmente por álcoois e aldeídos e apresenta atividade fungicida contra Candida spp. em suas formas planctônicas e biofilme.

https://doi.org/10.1590/1519-6984.264875

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers
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Costa, A. O. C.

; Rego, R. I. A.

; Andrade, H. H. N.

; Costa, T. K. V. L.

; Salvadori, M. G. S. S.

; Almeida, R. N.

; Castro, R. D.

Brazilian Journal of Biology

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2023, Volume 83 elocation e271781

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Due to the complex nature of pain and the participation of physical, cognitive, psychological and behavioral aspects, pain management has several approaches. The use of medicinal plants in developing countries is quite expressive. Seeking new options for the treatment of emerging or debilitating diseases. Therefore, the present study seeks to elucidate the effects of the monoterpene, citronellal, differentiating its activity by isomers (R)-(+) and (S)-(-) citronellal. The study used several methods to evaluate the effects of citronellal isomers on motor coordination, nociceptive response, and the involvement of opioid, glutamatergic, and transient receptor pathways. The methods included rota-rod, hot-plate, and formalin tests, as well as the use of specific inhibitors and agonists. Data were analyzed using inferential statistics with a 95% confidence level. Both isomers did not significantly affect the motor coordination of the studied animals. The isomer (S)-(-) citronellal showed better results in relation to its structural counterpart, managing to have an antinociceptive effect in the formalin and hot plate tests with a lower concentration (100 mg/kg) and presenting fewer side effects, however, the this study was not able to elucidate the mechanism of action of this isomer despite having activity in studies with substances that act on specific targets such as glutamate and capsaicin, its activity was not reversed with the use of antagonists for pathways related to nociception. While the (R)-(+) citronellal isomer, despite showing total activity only at a concentration of 150 mg/kg, was able to determine its mechanism of action related to the opioid pathway by reversing its activity by the antagonist naloxone, being this is a pathway already correlated with nociception control treatments, however, it is also related to some unwanted side effects. In this way, new studies are sought to elucidate the mechanism related to the isomer (S)-(-) citronellal and a possibility of use in other areas related to the treatment of pain or inflammation.

Resumo Devido à natureza complexa da dor e a sua participação de aspectos físicos, cognitivos, psicológicos e comportamentais, o manejo da dor possui diversas abordagens. O uso de plantas medicinais em países em desenvolvimento é bastante expressivo. Buscando novas opções para o tratamento de denças emergentes ou debilitantes. Portanto, o presente estudo busca elucidar os efeitos do monoterpeno, citronelal, diferenciando sua atividade pelos isômeros (R)-(+) e (S)-(-) citronelal. O estudo utilizou diversos métodos para avaliar os efeitos dos isômeros de citronelal na coordenação motora, resposta nociceptiva e o envolvimento de vias opioides, glutamatérgicas e de receptores transitórios. Os métodos incluíram testes de rota-rod, placa quente e formalina, além do uso de inibidores e agonistas específicos. Os dados foram analisados estatisticamente com um intervalo de confiança de 95%. Ambos os isomeros não afetaram significativamente a coordenação motora dos animais em estudo. O isômero (S)-(-) citronelal apresentou melhores resultados em relação ao seu homólogo estrutural, conseguindo ter um efeito antinociceptivo nos testes de formalina e placa quente com menor concentração (100 mg/kg) e apresentando menos efeitos colaterais, entretanto, o presente estudo não foi capaz de elucidar o mecanismo de ação deste isomero apesar de ter atividadade em estudos com substancias que agem em alvos específicos como glutamato e capsaicina, sua atividade não foi revertida com a utilização de antagonistas para as vias relacionadas à nocicepção. Enquanto o isômero (R)-(+) citronelal, apesar de apresentar de apresentar total atividade somente na concentração de 150 mg/kg, foi capaz de determinar seu mecanismo de ação relacionado à via opióide pela reversão da sua atividade pelo antagonista naloxona, sendo esta uma via já correlacionada com os tratamentos de controle da a nocicepção, no entanto, também está relacionada a alguns efeitos colaterais indesejados. Desta forma busca-se novos estudos para elucidação do mecanismo relacionados ao isomero (S)-(-) citronellal e uma possibilidade de utilização em outras areas relacionadas ao tratamento da dor ou inflamação.

https://doi.org/10.1590/1519-6984.271781

Comparative study of the doses of cytokinin in the quality of caigua (Cyclanthera pedata L.) in Peru
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Cruz Nieto, D. D.

; Castañeda Chirre, E. T.

; Castro Bartolomé, H. J.

; Legua Cárdenas, J. A.

; Nunja García, J. V.

; Vélez Chang, Y. J.

; Luque Vilca, O. M.

; Ito Díaz, R. R.

; Calizaya Llatasi, F. G.

; Leon Gomez, R.

; Maldonado Mamani, R. A.

Brazilian Journal of Biology

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2023, Volume 83 elocation e275635

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Bioavailability of nutrients, the scarcity of synthetic fertilisers, and the rising cost of fuel have all contributed to an increase in production costs, which has in turn reduced crop productivity and led scientists to seek out new methods to ensure high-quality output. In this context, various cytokinins dosages were tested in Peru to see whether they affected the quality of caigua, in an effort to address these issues. To mitigate these problems, a pot experiment was carried out to check the effects of various doses of cytokinin in the quality of caigua in Peru. The experiment consisted of 5 treatments including (0, 50, 100, 150 and 200 mL of cytokinin) by using (Anthesis Plus per 200 L of water) as a source, each with three replicates and placed following a randomized complete block design (RCBD). Treatment with 100 mL of cytokinins foliar analysis resulted in a caigua length of 18.9 cm, an increase in diameter of 5.65 cm, and an improvement in pulp thickness of 7.60 millimeters. Physiological parameters of caigua plants taken after 45 days of sowing were considerably improved with the same treatment. Similarly, N, K and Zn concentration in leaf was higher in case of 100 mL of cytokinins foliar analysis. Therefore, policymakers must advise using the recommended quantity of cytokinins to bring about regime transition, and formers can gain by injecting 100 mL of cytokinins to boost production and the economy. It was concluded that the adequate dose of cytokinins is in treatment T3, which raised value of potassium concentration in leaves, this influenced optimal development, strengthening against environmental stress and therefore quality. For this reason, research was carried out on the comparative study of cytokinin doses in the quality of caigua in Peru; the objective was to determine the appropriate dose to obtain higher quality fruit. Likewise, it was underlined that the objective was to employ an ecological alternative of plant origin such as the usage of phytohormone that stimulates the growth of the plant and consequently the quality of the fruit. The obtained the results were served as a recommendation for farmers in the area.

Resumo A biodisponibilidade de nutrientes, a escassez de fertilizantes sintéticos e o aumento do custo dos combustíveis contribuíram para um aumento nos custos de produção, o que, por sua vez, reduziu a produtividade das culturas e levou os cientistas a procurar novos métodos para garantir resultados de alta qualidade. Neste contexto, várias dosagens de citocininas foram testadas no Peru para examinar se afetavam a qualidade do caigua, num esforço para resolver estes problemas. Para mitigar esses problemas, foi realizado um experimento em vaso para verificar os efeitos de diversas doses de citocinina na qualidade do caigua no Peru. O experimento consistiu de cinco tratamentos, incluindo 0, 50, 100, 150 e 200 mL de citocinina utilizando Anthesis Plus por 200 L de água como fonte, cada um com três repetições e dispostos seguindo um delineamento em blocos completos casualizados (RCBD). O tratamento com 100 mL de análise foliar de citocininas resultou em comprimento de caigua de 18,9 cm, aumento de diâmetro de 5,65 cm e melhora na espessura da polpa de 7,60 mm. Os parâmetros fisiológicos das plantas de caigua colhidas após 45 dias da semeadura melhoraram consideravelmente com o mesmo tratamento. Da mesma forma, a concentração de N, K e Zn nas folhas foi maior no caso da análise foliar de 100 mL de citocininas. Portanto, os decisores políticos devem aconselhar a utilização da quantidade recomendada de citocininas para provocar a transição de regime, e os primeiros podem ganhar injetando 100 mL de citocininas para impulsionar a produção e a economia. Concluiu-se que a dose adequada de citocininas está no tratamento T3, que elevou o valor da concentração de potássio nas folhas, isso influenciou no desenvolvimento ideal, no fortalecimento contra o estresse ambiental e consequentemente na qualidade. Por esse motivo, foram realizadas pesquisas sobre o estudo comparativo de doses de citocinina na qualidade do caigua no Peru; o objetivo foi determinar a dose adequada para obter frutos de maior qualidade. Da mesma forma, foi sublinhado que o objetivo era empregar uma alternativa ecológica de origem vegetal, como a utilização de fito-hormona que estimulasse o crescimento da planta e, consequentemente, a qualidade do fruto. Os resultados obtidos serviram de recomendação para os agricultores da região.

https://doi.org/10.1590/1519-6984.275635

Ipomoea (Convolvulaceae) plants as new hosts of Tetranychus ludeni (Acari: Tetranychidae) Convolvulaceae (Convolvulaceae Acari (Acari Tetranychidae
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Cabral, M. J. S.

; Santos, A. A.

; Castro, B. M. C.

; Pinheiro, R. A.

; Santos, J. B.

; Leite, G. L. D.

; Zanuncio, J. C.

; Soares, M. A.

Brazilian Journal of Biology

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2023, Volume 83 elocation e269866

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1519-6984.269866

Influence of the Local Structure on the Photocatalytic Properties of Zinc Spinel Ferrite Nanoparticles
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Biazati, Luciana B.

; Lorenzini, Lucas

; Ferreira, Sandra A. D.

; Porto, Arilza O.

; Castro, Eustáquio V. R. de

; Fabris, José D.

; Freitas, Marcos B. J. G. de

; Lelis, Maria de Fátima F.

Journal of the Brazilian Chemical Society

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Fev 2022, Volume 33 Nº 2 Páginas 135 - 142

Resumo: En | Texto: En | PDF: En

The correlation between iron distribution in octahedral or tetrahedral sites in synthetic magnetite and zinc spinel ferrites and their catalytic properties were investigated in this work. The zinc-doped nanomagnetites were prepared by co-precipitation method and annealed at 420 °C. X-ray diffraction, UV-Vis, X-ray absorption and 57Fe Mössbauer spectroscopies were used to identify iron sites. The obtained results showed that ZnII replaces the relatively smaller FeIII cation in the tetrahedral sites, increasing the cubic lattice dimension, and this replacement remarkably enhances the catalytic effectiveness of the Zn-spinel ferrite towards the indigo carmine degradation compared to undoped magnetite. The indigo carmine degradation experiments were carried out using photo-Fenton method in which 50 mL of indigo carmine dye aqueous solutions (20 mg L−1, pH 3.0), 20 mg ZnxFe(3-x)O4, and 2.0 mL H2O2 (aqueous solution at 0.028 mol L−1) were placed under UV light at 25 °C. Under these experimental conditions the degradation rate of indigo carmine was superior to 98%.

https://doi.org/10.21577/0103-5053.20210130

Genetic regulation of the ompX porin of Salmonella Typhimurium in response to hydrogen peroxide stress
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Briones, A. C.

; Lorca, D.

; Cofre, A.

; Cabezas, C. E.

; Krüger, G. I.

; Pardo-Esté, C.

; Baquedano, M. S.

; Salinas, C. R.

; Espinoza, M.

; Castro-Severyn, J.

; Remonsellez, F.

; Hidalgo, A. A.

; Morales, E. H.

; Saavedra, C. P.

Biological Research

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2022, Volume 55 elocation 8

Resumo: En | Texto: En | PDF: En

Abstract Background: Salmonella Typhimurium is a Gram negative pathogen that causes a systemic disease in mice resembling typhoid fever. During its infective cycle, S. Typhimurium is phagocytized by macrophages and proliferates inside a Salmonella containing vacuole where Salmonella is exposed and survives oxidative stress induced by H2O2 through modulation of gene expression. After exposure of Salmonella to H2O2, the expression of the porin encoding gene ompX increases, as previously shown by microarray analysis. Expression of ompX mRNA is regulated at a post transcriptional level by MicA and CyaR sRNAs in aerobiosis. In addition, sequence analysis predicts a site for OxyS sRNA in ompX mRNA. Results: In this work we sought to evaluate the transcriptional and post transcriptional regulation of ompX under H2O2 stress. We demonstrate that ompX expression is induced at the transcriptional level in S . Typhimurium under such conditions. Unexpectedly, an increase in ompX gene transcript and promoter activity after challenges with H2O2 does not translate into increased protein levels in the wild type strain, suggesting that ompX mRNA is also regulated at a post transcriptional level, at least under oxidative stress. In silico gene sequence analysis predicted that sRNAs CyaR, MicA, and OxyS could regulate ompX mRNA levels. Using rifampicin to inhibit mRNA expression, we show that the sRNAs (MicA, CyaR and OxyS) and the sRNA:mRNA chaperone Hfq positively modulate ompX mRNA levels under H2O2 induced stress in Salmonella during the exponential growth phase in Lennox broth. Conclusions: Our results demonstrate that ompX mRNA is regulated in response to H2O2 by the sRNAs CyaR, MicA and OxyS is Salmonella Typhimurium.

https://doi.org/10.1186/s40659-022-00377-3 41 downloads

Guía de práctica clínica de la Sociedad Interamericana de Cardiología sobre prevención primaria de enfermedad cardiovascular en la mujer
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Sueldo, Mildren A. del

; Rivera, María A. Mendonça

; Sánchez-Zambrano, Martha B.

; Zilberman, Judith

; Múnera-Echeverri, Ana G.

; Paniagua, María

; Campos-Alcántara, Lourdes

; Almonte, Claudia

; Paix-Gonzales, Amalia

; Anchique-Santos, Claudia V.

; Coronel, Claudine J.

; Castillo, Gabriela

; Parra-Machuca, María G.

; Duro, Ivanna

; Varletta, Paola

; Delgado, Patricia

; Volberg, Verónica I.

; Puente-Barragán, Adriana C.

; Rodríguez, Adriana

; Rotta-Rotta, Aida

; Fernández, Anabela

; Izeta-Gutiérrez, Ana C.

; Ancona-Vadillo, Ana E.

; Aquieri, Analía

; Corrales, Andrea

; Simeone, Andrea

; Rubilar, Bibiana

; Artucio, Carolina

; Pimentel-Fernández, Carolina

; Marques-Santos, Celi

; Saldarriaga, Clara

; Chávez, Christian

; Cáceres, Cristina

; Ibarrola, Dahiana

; Barranco, Daniela

; Muñoz-Ortiz, Edison

; Ruiz-Gastelum, Edith D.

; Bianco, Eduardo

; Murguía, Elena

; Soto, Enrique

; Rodríguez-Caballero, Fabiola

; Otiniano-Costa, Fanny

; Valentino, Giovanna

; Rodríguez-Cermeño, Iris B.

; Rivera, Ivan R.

; Gándara-Ricardo, Jairo A.

; Velásquez-Penagos, Jesús A.

; Torales, Judith

; Scavenius, Karina

; Dueñas-Criado, Karen

; García, Laura

; Roballo, Laura

; Kazelian, Lucía R.

; Coussirat-Liendo, Macarena

; Costa-Almeida, María C.

; Drever, Mariana

; Lujambio, Mariela

; Castro, Marildes L.

; Rodríguez-Sifuentes, Maritza

; Acevedo, Mónica

; Giambruno, Mónica

; Ramírez, Mónica

; Gómez, Nancy

; Gutiérrez-Castillo, Narcisa

; Greatty, Onelia

; Harwicz, Paola

; Notaro, Patricia

; Falcón, Rocío

; López, Rosario

; Montefilpo, Sady

; Ramírez-Flores, Sara

; Verdugo, Silvina

; Murguía, Soledad

; Constantini, Sonia

; Vieira, Thais C.

; Michelis, Virginia

; Serra, César M.

Archivos de cardiología de México

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2022, Volume 92 Supl. 2 Páginas 1 - 68

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.24875/acm.22000071 450 downloads

10.

Fusión y estereopsis en niños con ambliopía refractiva
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Hernández-Santos, Lourdes R.

; Cárdenas-Díaz, Taimí

; Méndez-Sánchez, Teresita de J.

; Castro-Pérez, Pedro D.

; Pons-Castro, Lucy

Revista mexicana de oftalmología

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Dez 2021, Volume 95 Nº 6 Páginas 252 - 258

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: To determine the binocular function in patients with refractive amblyopia. Method: Cross-sectional study in patients between 5 and 18 years old with refractive amblyopia treated for the first time in the pediatric ophthalmology and strabismus consultation of the Instituto Cubano de Oftalmología Ramón Pando Ferrer. Results: No significant correlation was found between the depth of amblyopia and the magnitude of anisometropia in the right eye (p = 0.217) or in the left eye (p = −0.130), and neither between the magnitude of anisometropia and stereopsis (p = 0.260). Patients with isoametropic amblyopia reached a subnormal stereopsis >100" in 53.3%. Conclusions: There is no association between the magnitude of anisometropia and the depth of amblyopia, fusion and stereopsis. In most patients with refractive amblyopia, stereopsis is deteriorated, thus affecting binocular function.

Resumen Objetivo: Determinar la función binocular en pacientes con ambliopía refractiva. Método: Estudio transversal en pacientes entre 5 y 18 años con ambliopía refractiva atendidos por vez primera en la consulta de oftalmología pediátrica y estrabismo del Instituto Cubano de Oftalmología Ramón Pando Ferrer. Resultados: No se halló correlación significativa entre la profundidad de la ambliopía y la magnitud de la anisometropía en el ojo derecho (p = 0.217) ni en el ojo izquierdo (p = −0.130), y tampoco entre la magnitud de la anisometropía y la estereopsis (p = 0.260). El 53.3% de los pacientes con ambliopía isoametrópica alcanzaron una estereopsis subnormal > 100". Conclusiones: No se presenta asociación entre la magnitud de la anisometropía y la profundidad de la ambliopía, la fusión y la estereopsis. En la mayoría de los pacientes con ambliopía refractiva se deteriora la estereopsis, afectándose así la función binocular.

https://doi.org/10.24875/rmo.m21000201 82 downloads

11.

Growth and hematological responses of tambaqui, Colossoma macropomum fed different levels of rice, Oryza spp.
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Aride, P. H. R.

; Oliveira, A. M.

; Ferreira, M. S.

; Liebl, A. R. S.

; Comassetto, L. E.

; Ladislau, D. S.

; Bassul, L. A.

; Silva, B. R.

; Mattos, D. C.

; Lavander, H. D.

; Souza, A. B.

; Polese, M. F.

; Ribeiro, M.W.S.

; Castro, P. D. S.

; Oliveira, A. T.

Brazilian Journal of Biology

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Dez 2021, Volume 81 Nº 4 Páginas 962 - 968

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O tambaqui Colossoma macropomum é um peixe de importância na aquicultura brasileira, especialmente na região amazônica. O arroz silvestre é comum nas planícies inundadas dos rios de aguas barrentas da Amazônia. O objetivo deste trabalho foi analisar os efeitos combinados do treinamento físico e dos níveis dietéticos de Oryza spp. nos parâmetros hematológicos, consumo de alimentos, eficiência de conversão, taxa de crescimento e desempenho de natação deste peixe. Dietas contendo 45% de arroz apresentaram o melhor desempenho para tambaquis. As dietas contendo 15% e 30% não afetaram esses índices, indicando que alguma quantidade de arroz pode ser usada como fonte de energia alternativa para esta importante espécie dentro da aquicultura.

Abstract The tambaqui (Colossoma macropomum) is a fish of primary importance in South American aquaculture, principally in the Amazon region and has a particularly unique diet in the wild. Oryza spp, or Wild rice as it is commonly known, is native to the floodplains of muddy rivers in the Amazon region. The aim of this study was to analyze the physical performance and the effects of dietary levels of Oryza spp. via the hematological parameters, total food intake, conversion efficiency, growth ratio and swimming performance of this fish. Diets containing 45% Oryza spp. induced the best performance in tambaqui. Diets containing 15% and 30% did not affect these indices, thus indicating that this amount of Oryza can be used as an alternative energy source for this important species within Brazilian aquaculture.

https://doi.org/10.1590/1519-6984.232560 2708 downloads

12.

Shelf Life of Bioactive Compounds from Acerola Pulp (Malpighia spp.) through Freeze-Drying and Microencapsulation
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Saqueti, Bruno H. F.

; Alves, Eloize S.

; Castro, Matheus C.

; Santos, Patrícia D. S. dos

; Sinosaki, Nayane B. M.

; Senes, Carlos E. R.

; Visentainer, Jesuí V.

; Santos, Oscar O.

Journal of the Brazilian Chemical Society

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Out 2021, Volume 32 Nº 10 Páginas 2009 - 2016

Resumo: En | Texto: En | PDF: En

Acerola is a tropical fruit with a large industrial and commercial appeal due to its organoleptic qualities and bioactive compound-rich nature. Thus, as bioactive compounds (BC) stability is of great interest in the food industry, assessment of preserving techniques to prolong shelf life has become imperative. Hence, the purpose of this study was to evaluate how storage affects BC conservation in microencapsulated and lyophilized acerola pulps over 180 days. For this matter, antioxidant tests, physical-chemical analyzes, and vitamin C analysis by mass spectrometry were performed. Results indicated that microencapsulation better preserved the antioxidants in acerola pulp compared to the other preservation technologies employed. This is due to the greater BC concentration in the microencapsulated, as well as the pH reduction. Furthermore, over 180 days, microencapsulation better preserved the target compounds in acerola pulp compared to lyophilization, as evidenced by the superior content of BC in the former treatment, making it an appealing option for the food sector.

https://doi.org/10.21577/0103-5053.20210096 48 downloads

13.

Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents
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Dias, Flaviana R. F.

; Guerra, Fabiana S.

; Lima, Fernanda A.

; Castro, Yasmin K. C. de

; Ferreira, Vitor F.

; Campos, Vinícius R.

; Fernandes, Patrícia D.

; Cunha, Anna C.

Journal of the Brazilian Chemical Society

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Mar 2021, Volume 32 Nº 3 Páginas 476 - 489

Resumo: En | Texto: En | PDF: En

In this work, we report the synthesis of three series of carbohydrate-based benzo[f]indole-4,9-diones and amino-1,4-naphthoquinone derivatives and evaluated their cytotoxic activity against eight human cancer cell lines. Several compounds showed a promising cytotoxic activity toward the tumor cell lines (half maximal inhibitory concentration (IC50) < 10.0 μM). The importance of the substitution pattern of the quinone derivatives on the antitumor activity was also discussed. 3-Carboethoxy-2-methyl-benzo[f]indole-4,9-dione derivatives were more cytotoxic than their parent compounds and amino-1,4-naphthoquinones. Unlike clinically useful anticancer agent doxorubicin, the majority of synthesized compounds did not exhibit any lytic effects against erythrocytes or normal human leukocytes.

https://doi.org/10.21577/0103-5053.20200202 219 downloads

14.

Hematological parameters of three species of the peacock bass (Cichla spp.) from Balbina lake, Presidente Figueiredo, Amazonas, Brazil
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Castro, P. D. S.

; Ladislau, D. S.

; Ribeiro, M. W. S.

; Lopes, A. C. C.

; Lavander, H. D.

; Bassul, L. A.

; Mattos, D. C.

; Liebl, A. R. S.

; Aride, P. H. R.

; Oliveira, A. T.

Brazilian Journal of Biology

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Fev 2021, Volume 81 Nº 1 Páginas 62 - 68

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O presente trabalho teve por objetivo caracterizar e comparar as variáveis hematológicas (eritrograma, trombograma, leucograma e metabólitos plasmáticos) de três espécies de tucunarés Cichla monoculus, Cichla temensis e Cichla vazzoleri. Um total de 45 animais foi capturado no lago de Balbina, Presidente Figueiredo, Amazonas, com auxílio de vara e carretilha, linha de mão com isca natural e artificial, sendo 15 C. monoculos, 15 C. temensis e 15 C. vazzoleri. O sangue foi retirado por punção caudal da aorta dorsal e os dados hematológicos foram determinados de acordo com metodologia previamente descrita na literatura. No eritrograma foram observadas similaridades entre as espécies, o trombograma demonstrou diferenças entre o C. vazzoleri e as demais espécies estudadas (C. monoculus e C. temensis), a contagem total de leucócitos demonstrou que em C. temensis e C. vazzoleri os valores são superiores ao C. monoculus. Foi demonstrado que os linfócitos foram às células predominantes em C. temensis e C. vazzoleri, diferentemente do C. monoculos que apresentou como leucócito predominante os monócitos. Nos metabólitos plasmáticos, foi possível observar diferenças entre as três espécies de tucunarés nos níveis de glicose, colesterol, uréia e potássio. Conclui-se que as três espécies de tucunarés apresentam diferenciação hematológica, indicando que as mesmas possuem respostas diferenciadas, na resposta imunológica de suas células do sangue e na fisiologia dos metabólitos plasmáticos.

Abstract The objective of this study was to characterize and compare the hematological variables (erythrogram, thrombogram, leukogram and plasma metabolites) of three cichlid species: Cichla monoculus, Cichla temensis and Cichla vazzoleri. A total of 45 specimens were captured in Balbina lake, Presidente Figueiredo, Amazonas, Brazil, with the aid of a rod and reel or hand line, with natural or artificial bait: 15 C. monoculus, 15 C. temensis and 15 C. vazzoleri. Their blood was removed by means of caudal puncture of the dorsal aorta, and hematological data were determined in accordance with methodology previously described in the literature. The erythrogram showed similarities between the species, while the thrombogram showed differences between C. vazzoleri and the other species studied (C. monoculus and C. temensis). The total leukocyte counts for C. temensis and C. vazzoleri were higher than those of C. monoculus. The predominant leukocyte in C. temensis and C. vazzoleri was lymphocytes, whereas it was monocytes in C. monoculus. The plasma metabolites showed differences between the three cichlid species, regarding their glucose, cholesterol, urea and potassium levels. It is concluded that these three species present hematological differentiation, thus indicating that they have differentiated blood-cell immune responses and plasma metabolite physiology.

https://doi.org/10.1590/1519-6984.219409 409 downloads

15.

Restricted feeding modulates peripheral clocks and nutrient sensing pathways in rats
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Rodrigues, Luis Guilherme F.

; de Araujo, Leonardo D.

; Roa, Silvia L. R.

; Bueno, Ana C.

; Uchoa, Ernane T.

; Antunes-Rodrigues, José

; Moreira, Ayrton C.

; Elias, Lucila L. K.

; de Castro, Margaret

; Martins, Clarissa S.

Archives of Endocrinology and Metabolism

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2021, Volume 65 Nº 5 Páginas 549 - 561

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Feeding restriction in rats alters the oscillators in suprachiasmatic, paraventricular, and arcuate nuclei, hypothalamic areas involved in food intake. In the present study, using the same animals and experimental protocol, we aimed to analyze if food restriction could reset clock genes ( Clock, Bmal1 ) and genes involved in lipid metabolism ( Pgc1a, Pparg, Ucp2 ) through nutrient-sensing pathways ( Sirt1, Ampk, Nampt ) in peripheral tissues. Materials and methods: Rats were grouped according to food access: Control group (CG, food ad libitum ), Restricted night-fed (RF-n, food access during 2 h at night), Restricted day-fed (RF-d, food access during 2 h in the daytime), and Day-fed (DF, food access during 12 h in the daytime). After 21 days, rats were decapitated at ZT3 (0900-1000 h), ZT11 (1700-1800 h), or ZT17 (2300-2400 h). Blood, liver, brown (BAT) and peri-epididymal (PAT) adipose tissues were collected. Plasma corticosterone and gene expression were evaluated by radioimmunoassay and qPCR, respectively. Results: In the liver, the expression pattern of Clock and Bmal1 shifted when food access was dissociated from rat nocturnal activity; this phenomenon was attenuated in adipose tissues. Daytime feeding also inverted the profile of energy-sensing and lipid metabolism-related genes in the liver, whereas calorie restriction induced a pre-feeding increased expression of these genes. In adipose tissues, Sirt1 expression was modified by daytime feeding and calorie restriction, with concomitant expression of Pgc1a , Pparg , and Ucp2 but not Ampk and Nampt . Conclusion: Feeding restriction reset clock genes and genes involved in lipid metabolism through nutrient-sensing-related genes in rat liver, brown, and peri-epididymal adipose tissues.

https://doi.org/10.20945/2359-3997000000407 31 downloads

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