In the present study, a novel magnetic dispersive solid-phase extraction method using molecularly imprinted polymer synthesized through semi-covalent imprinting approach was developed for cholesterol (CHO) determination in milk samples by high-performance liquid chromatography with diode array detector (HPLC-DAD). The adsorbent named Fe3O4/SiO2/MIP (MIP: molecularly imprinted polymers) was prepared through sol-gel polymerization of 3-(triethoxysilyl)propyl isocyanate (ICPTES) covalently bonded to CHO with tetraethoxysilane (TEOS), in the presence of Fe3O4/SiO2 particles. The adsorbent was characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS) and scanning electron microscopy (SEM). The proposed molecularly imprinted polymer-based magnetic dispersive solid-phase extraction method (MIP-MDSPE) was based on vortex-assisted preconcentration of 10.0 mL of CHO solution in chloroform as donor phase using 10.0 mg of Fe3O4/SiO2/MIP during 60 s. After this step, the magnetic particles were collected using a permanent magnet and the vortex-assisted elution was carried with 500 µL of ethanol during 180 s. A wide analytical curve ranging from 38.5 to 25000 µg L-1 (determination coefficient (R2) = 0.998) and low limits of detection (LOD) and quantification (LOQ) 11.5 and 38.5 µg L 1, respectively, were obtained. Milk samples (whole and reduced-fat milk) were subjected to MIP-MDSPE method after saponification reaction followed by CHO extraction with chloroform. Using external calibration, the CHO concentration ranged from 99.2 (reduced-fat milk) to 397.6 mg kg 1 (whole milk) and the accuracy was attested by addition and recovery tests (92 to 97%).

Abstract We present briefly the LLAMA sub-mm radiotelescope, a joint project of Argentina and Brazil, being mounted in the Andes, Argentina, at 4800 m altitude. Here we focus on the activities that are going on mostly under the responsibility of Brazil, like the high frequency receivers, parts of the back-end and electronics, the optical system of the telescope to bring the radiation to the receivers, the equipment needed for the integration and verification phase (optical telescope and holography) and the computation system.The main scientific applications that are planned are dscribed. We also report on a joint program with BRICS countries approved in 2019, which will involve the use of LLAMA for testing high-frequency receivers.

Resumo Este artigo descreve o comportamento da aderência de um concreto leve estrutural com pérolas de EPS (CLEPE) sob carregamento monotônico, com base em revisão bibliográfica e em ensaios de arrancamento. Os resultados desses ensaios de CLEPE foram comparados com os de um concreto convencional (CC) e com os valores baseados nas recomendações da ABNT NBR 6118:2014 - Projeto de estruturas de concreto. Foram analisados os ensaios de arrancamento de dois lotes de CLEPE e um de CC, totalizando 60 ensaios. Também foram determinadas características mecânicas, tais como: resistência à compressão e resistência à tração por compressão diametral. Os resultados calculados de acordo com a norma citada foram muito diferentes dos obtidos nos ensaios, indicando que os valores teóricos são mais conservadores do que os experimentais. Verificou-se também que é possível usar o CLEPE em estruturas, no que diz respeito à adequada aderência da armadura ao concreto.

Abstract This paper describes the adherence behavior of a structural lightweight concrete with EPS beads (SLCEB) in a monotonic loading, based in a bibliographic review and in pull-out tests. The results of these SLCEB tests were compared with those of an ordinary concrete (OC) and with the values based in indications of the Brazilian code ABNT NBR 6118:2014 - Design of concrete structures. The pull-out tests of two batches of SLCEB and one of OC were analyzed, in a total of 60 tests. Mechanical characteristics were determined too, such as: compressive strength and tensile strength in split cylinder test. The calculated results according to the above mentioned standard were very different from those obtained in the tests, indicating that the theoretical values are more conservative than the experimental ones. It was also verified that it is possible to use SLCEB in structures with respect to the adequate adherence of reinforcement in the concrete.

Considerando a cooperação internacional para o desenvolvimento (CID) como campo político cujas bases filosóficas - a crença no progresso, a esperança como tarefa política ou imperativo, o desenvolvimento como meta - alimentam relações de assimetria, hierarquia e dependência, são apresentados e discutidos, neste artigo, os resultados de uma pesquisa empírica realizada em Duque de Caxias (região metropolitana do Rio de Janeiro) entre setembro de 2010 e janeiro de 2012, a fim de responder a duas perguntas principais: 1) o que revelam as práticas das agências internacionais atuantes no desenvolvimento local de Duque de Caxias? 2) o que o contexto local desse município da região metropolitana do Rio de Janeiro ilustra acerca das tendências analisadas pela literatura mais crítica sobre o papel da cooperação para o desenvolvimento? Valendo-se de autores críticos sobre o papel político das organizações da CID - B. Cooke, W. Easterley, A. Escobar, T. Hayter, G. Rist, entre outros - e, da pesquisa, de natureza qualitativa, é descrito e analisado o modo de atuação das agências internacionais, sejam elas governamentais multilaterais ou bilaterais, empresas privadas, organizações filantrópicas ou associações, na definição e implementação de estratégias de desenvolvimento em Duque de Caxias. Conclui-se que as organizações internacionais raramente atuam no plano municipal de Duque de Caxias, limitando-se a agir mais indiretamente na concepção de projetos pontuais de apoio ao desenvolvimento e exercendo seu poder de influência sobre as agendas de políticas públicas de âmbito local.

Considering that international development cooperation is a political field whose main philosophical tenets (the belief in progress, hope as endeavor or policy imperative, the development goal) bring about relationships of asymmetry, hierarchy and dependence, this article presents and discusses the results of an empirical research conducted in Duque de Caxias between September 2010 and January 2012 in order to answer two major questions: what do practices of international agencies currently active in Duque de Caxias reveal in political and institutional terms? What does the local context of this municipality situated in the metropolitan region of Rio de Janeiro illustrate about the trends analyzed by the more critical literature on the role of development cooperation agencies? Building upon the work of critical analyses of international agencies' political role (such as B. Cooke, W. Easterley, A. Escobar, T. Hayter or G. Rist), this qualitative research describes and analyzes modes of actionof these agencies, be they bilateral or multilateral governmental organizations, private foundations, charitable organizations or voluntary associations in the definition and implementation of development strategies in Duque de Caxias. This article concludes that international agencies seldom act at the city level, limiting themselves to participation in the design of specific development projects and exercise of their power to influence public policy agendas at the local level.

INTRODUÇÃO: Estudos recentes incluindo pacientes portadores de doença coronária estável sugerem ausência de benefício clínico da estratégia inicial de intervenção coronária percutânea com stents não-farmacológicos associada a terapia medicamentosa otimizada vs. terapia medicamentosa otimizada isolada. No entanto, o tratamento ideal para pacientes com doença coronária estável no mundo real permanece controverso. Reportamos o impacto dos stents farmacológicos (SF) em pacientes portadores de doença coronária estável tratados na prática clínica diária. MÉTODO: Entre maio de 2002 e novembro de 2009, 1.814 pacientes portadores de doença coronária estável (angina estável ou isquemia silenciosa) foram prospectivamente incluídos no Registro DESIRE, e o seguimento clínico de até 8 anos (média de 3,9 ± 2 anos) foi realizado em 98% desses pacientes. RESULTADOS: A média das idades era de 64,2 ± 10,8 anos, 28% tinham diabetes melito, 21% tinham infarto do miocárdio prévio e 51,7%, revascularização prévia. A artéria descendente anterior foi o vaso-alvo mais tratado (42%), e, considerando-se o total de lesões (n = 2.701), 66,3% delas eram de elevada complexidade (tipos B2/C). Ao final do procedimento, o sucesso angiográfico foi de 99%. No seguimento clínico tardio, as taxas cumulativas de eventos adversos foram: morte cardíaca, 3,4%; infarto do miocárdio, 5,5%; revascularização da lesão-alvo (RLA), 4,8%; e trombose de stent, 0,8%. CONCLUSÃO: A utilização de SF na doença coronária estável esteve associada a excelente evolução clínica tardia, incluindo taxa cumulativa de RLA < 5%, e segurança sustentada. Comparados a dados históricos, tais achados demonstram grande benefício dos SF nessa população, sugerindo que a intervenção coronária percutânea com SF pode ser uma alternativa inicial segura e eficaz no tratamento de pacientes com doença coronária estável.

BACKGROUND: Recent studies in patients with stable coronary artery disease suggest there is no clinical benefit of the initial strategy of percutaneous coronary intervention with bare metal stents associated to optimal medical therapy (OMT) vs OMT alone. However, the best therapeutic option for patients with stable coronary artery disease in the real world remains controversial. We report the impact of drug eluting stents (DES) in patients with stable coronary artery disease treated in the daily clinical practice. METHOD: From May 2002 to November 2009, 1,814 patients with stable coronary artery disease (stable angina or silent ischemia) were prospectively included in the DESIRE Registry and 98% of the patients were followed up to 8 years (mean 3.9 ± 2 years). RESULTS: Mean age was 64.2 ± 10.8 years, 28% had diabetes mellitus, 21% had a prior myocardial infarction and 51.7% had a prior revascularization. Left anterior descending artery was treated in 42% of the patients. When all of the lesions (n = 2,701) were taken into consideration, 66.3% were classified as complex B2/C lesions. Angiographic success was 99%. The cumulative rate of adverse events in the late clinical follow-up was: cardiac death, 3.4%; myocardial infarction, 5.5%; target-lesion revascularization (TLR), 4.8%; and stent thrombosis, 0.8%. CONCLUSION: The use of DES in stable coronary artery disease was associated to excellent late clinical follow-up including a cumulative TLR rate < 5% and stent thrombosis < 1%. When compared to historical data, such findings show a great benefit of DES in this population, suggesting that percutaneous coronary intervention with DES is a safe and effective initial strategy in patients with stable coronary artery disease.

A reação radicalar mediada por hidreto de tri-n-butilestanho de 2,3-di-O-benzil-4-O-trans-cinamil-6-desoxi-6-(2-iodobenzoilamino)- alfa-D-galactopyranosídeo de metila levou à formação de um produto inesperado, o 2,3-di-O-benzil-4-O-trans-cinamil-6-desoxi-6-(2-tri- n-butilestanhobenzoilamino)-alfa-D-galactopyranosídeo de metila. A estrutura do produto foi elucidada por meio das espectrometrias de RMN unidimensionais (¹H, 13C e DEPT) e bidimensionais (COSY e HMQC) e confirmada por espectrometria de massas. Foram apresentadas propostas de mecanismos para explicar a formação do derivado organoestanho.

The tri-n-butyltin hydride-mediated reaction of methyl 2,3-di-O-benzyl-4-O-trans-cinnamyl -6-deoxy-6-(2-iodobenzoylamino)-alpha-D-galactopyranoside afforded an unexpected aryltributyltin compound. The structure of this new tetraorganotin(IV) product has been elucidated by ¹H, 13C NMR spectroscopy, COSY and HMQC experiments and electrospray ionization mass spectrometry (ESI-MS). The formation of this new compound via a radical coupling reaction and a radical addition-elimination process is discussed.