Pesquisa | SciELO

Hematological problems are associated with Coronavirus disease 2019 (COVID-19). Respiratory impairment is the higher point studied, although without experimental studies related to the oxygen transport performed by erythrocytes. Therefore, we decided to investigate if erythrocytes from COVID-19 patients have their functionality changed. The case-control study included hospitalized patients with a positive real-time polymerase chain reaction (RT-PCR) result admitted to University Hospital. Volunteers (negative RT-PCR results) were recruited as a control group. Thus, we assessed different erythrocytes parameters, oxidative stress markers, and biophysical studies using whole blood and isolated hemoglobin. We found a decrease of 51% in oxygen uptake and reduced antioxidant enzyme activity in COVID-19 patients compared to controls. Raman spectrometry showed structural changes in the hemoglobin and lipids of the erythrocytes from COVID-19 patients; thus, these results were consolidated with an increase in Young’s modulus in erythrocytes followed by morphology changes. Besides, isolated hemoglobin from COVID-19 patients has a distinct interaction profile using a ligand model compared to the control. COVID-19 leads to structural, functional, and morphological damage to human erythrocytes. Our data showed structural and molecular changes and induction of oxidative stress in erythrocytes by COVID-19, a new perspective on the contribution of erythrocytes to a respiratory commitment in COVID-19.

https://doi.org/10.21577/0103-5053.20230031

Green Synthesis, Characterization and Antibacterial and Leishmanicidal Activities of Silver Nanoparticles Obtained from Aqueous Extract of Eucalyptus grandis
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Oliveira, Lucas M. F.

; Silva, Ueveton P. da

; Braga, João Pedro V.

; Teixeira, Álvaro V. N. C.

; Ribon, Andréa O. B.

; Varejão, Eduardo V. V.

; Coelho, Eduardo A. F.

; Freitas, Camila S. de

; Teixeira, Róbson R.

; Moreira, Renata P L.

Journal of the Brazilian Chemical Society

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Abr 2023, Volume 34 Nº 4 Páginas 527 - 536

Resumo: En | Texto: En | PDF: En

This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic band at 407 nm in the UV-Vis spectrum. The AgNPs presented a spherical shape and size of 9.7 ± 0.3 nm. The nanoparticles were stable over a month, indicating that E. grandis’ extract is suitable for their preparation and stabilization. The X-ray analysis showed that the crystallinity of AgNPs corresponded to the centered face phase of silver. The antibacterial and leishmanicidal activities of AgNPs were evaluated. The AgNPs presented antibacterial activity on the Gram-negative bacteria Escherichia coli at 53.9 µg mL-1. The leishmanicidal activity evaluation against promastigote forms of Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis showed that the biological response is dependent on the volume of AgNP suspension. It was demonstrated that L. infantum was more sensitive to the nanoparticle’s treatment than L. amazonensis and L. braziliensis. The treatment of L infantum promastigotes with 150 µL of AgNP suspension reduced parasite growth by 67.9%, a result which was similar to the treatment with 1 (66.7%) or 2 µL (70.6%) of amphotericin B used as a positive control.

https://doi.org/10.21577/0103-5053.20220126

How many species of Mollusca are there in Brazil? A collective taxonomic effort to reveal this still unknown diversity
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Machado, Fabrizio M.

; Miranda, Marcel S.

; Salvador, Rodrigo B.

; Pimenta, Alexandre D.

; Côrtes, Mariana O.

; Gomes, Jaime A.J.

; Miyahira, Igor C.

; Agudo-Padrón, Ignacio

; Oliveira, Cléo D.C.

; Caetano, Carlos H.S.

; Coelho, Paulo R.S.

; D’Ávila, Sthefane

; Arruda, Eliane P. de

; Almeida, Sérgio M. de

; Gomes, Suzete R.

; Alvim, Juliana

; Galvão-Filho, Hilton

; L. Ferreira-Júnior, Augusto

; Marques, Rodrigo C.

; Martins, Inês

; Souza, Leonardo S. de

; Arruda, Janine O.

; Cavallari, Daniel C.

; Santos, Sonia B. dos

; Pedro, Natan C.

; Salles, Anna C. de A.

; Dornellas, Ana P.S.

; Lima, Tarcilla C. de

; Amaral, Vanessa S. do

; Silva, Fernanda S.

; Passos, Flávio D.

; Thiengo, Silvana S.

; Leite, Tatiana S.

; Simone, Luiz R.L.

Zoologia (Curitiba)

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2023, Volume 40 elocation e23026

Resumo: En | Texto: En | PDF: En

ABSTRACT The expression ‘you need to know to conserve’ is a well-known cliche among biologists. Documenting the richness of a group of organisms is the first step towards understanding biodiversity and preparing efficient conservation plans. In this context, many efforts have been made to quantify the number of species on Earth and estimate the number of species still unknown to science. A few countries have complete and integrated databases estimating the approximate number of species recorded for their territory, particularly in the Global South. In Brazil, a country of continental dimensions, revealing the richness of the second most diverse clade of invertebrates (=Mollusca) has been a goal of taxonomists. Recently, in an unprecedented, collective, and integrated effort among Brazilian malacologists, it was possible to estimate how many valid species of molluscs are there in Brazil. In this effort, more than 30 mollusc experts joined together to update the Taxonomic Catalogue of the Brazilian Fauna (TCBF), a governmental website that allows a quick and real-time updating of all Metazoan. So far, more than 5,000 updates have been made in TCBF, indicating the presence of 3,552 valid species of molluscs in Brazil, distributed among the main clades as follows: Caudofoveata (10 spp.), Solenogastres (6 spp.), Polyplacophora (35 spp.), Scaphopoda (43 spp.), Cephalopoda (92 spp.), Bivalvia (629 spp.) and Gastropoda (2,737 spp.). The present study, in addition to demonstrating for the first time the richness of Brazilian molluscs, also presents the state of the art of this important phylum of invertebrates highlighting its most representative and neglected groups.

https://doi.org/10.1590/s1984-4689.v40.e23026

Cell therapy with adipose tissue-derived human stem cells in the urinary bladder improves detrusor contractility and reduces voiding residue
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Coelho, H. R. S.

; Neves, S. C.

; Menezes, J. N. S.

; Antoniolli-Silva, A. C. M. B.

; Oliveira, R. J.

Brazilian Journal of Biology

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2023, Volume 83 elocation e268540

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Detrusor hypocontractility (DH) is a disease without a gold standard treatment in traditional medicine. Therefore, there is a need to develop innovative therapies. The present report presents the case of a patient with DH who was transplanted with 2 x 106 adipose tissue-derived mesenchymal stem cells twice and achieved significant improvements in their quality of life. The results showed that cell therapy reduced the voiding residue from 1,800 mL to 800 mL, the maximum cystometric capacity from 800 to 550 mL, and bladder compliance from 77 to 36.6 mL/cmH2O. Cell therapy also increased the maximum flow from 3 to 11 mL/s, the detrusor pressure from 08 to 35 cmH2O, the urine volume from 267 to 524 mL and the bladder contractility index (BCI) value from 23 to 90. The International Continence on Incontinence Questionnaire - Short Form score decreased from 17 to 8. Given the above, it is inferred that the transplantation of adipose tissue-derived mesenchymal stem cells is an innovative and efficient therapeutic strategy for DH treatment and improves the quality of life of patients affected by this disease.

Resumo A Hipocontratilidade Detrusora (HD) é uma doença sem um tratamento padrão-ouro na medicina tradicional. Logo, há a necessidade de desenvolvimento de terapias inovadoras. O presente relato apresenta um caso de paciente com HD transplantado duas vezes com 2 x 106 células-tronco mesenquimais derivadas do tecido adiposo que obteve melhoras significativas em sua qualidade de vida. Os resultados demonstraram que a terapia celular reduziu o resíduo miccional de 1.800mL para 800mL; a Capacidade Cistométrica Máxima de 800 para 550mL; a complacência de 77 para 36,6mL/cmH2O. A terapia celular também aumentou o fluxo máximo de 3 para 11mL/s; a pressão detrusora de 08 para 35cmH2O; o volume urinado de 267 para 524mL e o índice de contratilidade vesical (BCI) de 23 para 90. O score do International Continence on Incontinence Questionare - Short Form passou de 17 para 8. Diante do exposto, infere-se que o transplante de células-tronco mesenquimais derivadas do tecido adiposo é uma estratégia terapêutica inovadora e eficiente para o tratamento da HD e para melhoria da qualidade de vida de pacientes acometidos por essa doença.

https://doi.org/10.1590/1519-6984.268540

Study of the Molecular Weight of Pullulan Produced by Aureobasidium pullulans from Industrial Waste
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Oliveira, Victor R. L.

; Coelho, Victória V.

; Sérvulo, Eliana F. C.

; Calado, Verônica M. de A.

Materials Research

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2023, Volume 26 Supl. 1 elocation e20230060

Resumo: En | Texto: En | PDF: En

The objective of this research was the sustainable development of pullulan and its structural and rheological characterization. In addition, the cultivation of the A. pullulans Y2092 strain by submerged fermentation on a laboratory scale was evaluated, valuing the use of industrial waste (residual brewery's yeast), RBY, and a low-cost renewable raw material VHP (very high polarization sugar). A 22 factorial statistical design of experiments was used to analyze the molecular weight of the pullulans produced. The maximum value of 1955 kDa was determined for the pullulan recovered after 96 h of fermentation in the mineral medium added with 70 g/L of VHP and 50 g/L of RBY. The FTIR analysis for the pullulan obtained was similar to the commercial pullulan. The rheological behavior of pullulan solutions is shown, evidencing the relationship between this property and Mw. The results from all analyses indicate that the pullulan obtained is suitable for the future production of biopolymeric films.

https://doi.org/10.1590/1980-5373-mr-2023-0060

Herpetofauna of protected areas in the Caatinga VIII: An updated checklist for the Serra das Confusões region with new data from Serra Vermelha, Piauí, Brazil
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Marques, Ricardo

; Garda, Adrian A.

; Furtado, Adriana P.

; Bruinjé, Andre C.

; Protázio, Arielson dos S.

; de Carvalho, Breno F.

; Vieira, Cecília R.

; Gomes, Dandara

; Pantoja, Davi L.

; Figueiredo, Diainara da S.

; Shepard, Donald B.

; Camurugi, Felipe

; Coelho, Felipe E. A.

; Magalhães, Felipe M.

; Caetano, Gabriel H. O.

; Colli, Guarino R.

; Paulino, Henrique M.

; Carvalho, Izabelle T. S.

; Graciene, Joedma

; Alvarenga, Júlio M.

; Clay, Natalie A.

; Albuquerque, Ralph L.

; Bosque, Renan J.

; Faria, Renato

; da Silveira-Filho, Ricardo R.

; Mângia, Sarah

; Cavalcante, Vitor H. G. L.

; Vieira, Washington L. S.

; da Silva, Willianilson P.

; Soares, Yan F. F.

; Mesquita, Daniel O.

Biota Neotropica

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2023, Volume 23 Nº 4 elocation e20231520

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract It is repeatedly stressed the need to characterize the extant biodiversity in tropical ecosystems. However, inventory studies are still progressing slowly in dry ecosystems, leading to the underestimation of their true biodiversity and hindering conservation efforts. In this study, we present primary and secondary data, along with an updated list of amphibians and reptiles from two localities in the São Francisco-Gurguéia region in Piauí. Additionally, we compare the species composition between nine areas within the Caatinga, which were sampled using standardized methods over the past ten years, to examine broader spatial patterns of community composition. To survey reptiles and amphibians, we employed similar methods and sampling efforts in two areas within the Serra das Confusões National Park (SCNP) region. Our surveys recorded a total of 73 species of amphibians and reptiles, of which 24 are new distribution records for the SCNP region. Consequently, our findings increase the known herpetofauna in the region to 94 species. Despite their proximity, the two sites in the SCNP region exhibited only 42% similarity in species composition, and they differed significantly from other areas within the Caatinga. Furthermore, even the closer Caatinga areas presented differences in species composition, highlighting the necessity to evaluate biodiversity across the landscape and contribute to understanding biogeographic patterns.

Resumo É repetidamente enfatizada a necessidade de caracterizar a biodiversidade vivente em ecossistemas tropicais. No entanto, os estudos de inventário ainda estão progredindo lentamente em ecossistemas secos, levando à subestimação de sua verdadeira biodiversidade e dificultando os esforços de conservação. Neste estudo, apresentamos dados primários e secundários, juntamente com uma lista atualizada de anfíbios e répteis de duas localidades na região de São Francisco-Gurguéia, do Piauí. Além disso, comparamos a composição de espécies entre nove áreas dentro da Caatinga, que foram amostradas usando métodos padronizados nos últimos dez anos, para examinar padrões espaciais mais amplos de composição da comunidade. Para estudar répteis e anfíbios, utilizamos métodos e esforços de amostragem semelhantes em duas áreas na região do Parque Nacional da Serra das Confusões (PNSC). Nossos levantamentos registraram um total de 73 espécies de anfíbios e répteis, das quais 24 são novos registros de distribuição para a região do PNSC. Consequentemente, nossos resultados aumentam a herpetofauna conhecida na região para 94 espécies. Apesar da proximidade, os dois locais na região do PNSC exibiram apenas 42% de similaridade na composição de espécies e diferiram significativamente de outras áreas dentro da Caatinga. Mesmo áreas mais próximas da Caatinga apresentaram diferenças na composição de espécies, destacando a necessidade de avaliar a biodiversidade em toda a paisagem e contribuir para a compreensão de padrões biogeográficos.

https://doi.org/10.1590/1676-0611-bn-2023-1520

Associação entre Bloqueio Atrioventricular e Mortalidade em Pacientes de Atenção Primária: O Estudo CODE
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Paixão, Gabriela Miana de Mattos

; Lima, Emilly M.

; Quadros, André B.

; Cabral, Daniel P. R.

; Coelho, Renato R.

; Oliveira, Derick M.

; Nascimento, Jamil de Souza

; Gomes, Paulo R.

; Ribeiro, Antonio L.

Arquivos Brasileiros de Cardiologia

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Out 2022, Volume 119 Nº 4 Páginas 564 - 571

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento O bloqueio atrioventricular (BAV) descreve um comprometimento na condução dos átrios para os ventrículos. Embora o curso clínico do BAV tenha sido avaliado, os achados são de países de alta renda e, portanto, não podem ser extrapolados para a população latina. Objetivo Avaliar a associação entre BAV e mortalidade. Métodos Foram incluídos pacientes do estudo CODE (Clinical Outcomes in Digital Electrocardiology), maiores de 16 anos que realizaram eletrocardiograma (ECG) digital de 2010 a 2017. Os ECGs foram relatados por cardiologistas e por software automatizado. Para avaliar a relação entre BAV e mortalidade, foram utilizados o modelo log-normal e as curvas de Kaplan-Meier com valores de p bicaudais < 0,05 considerados estatisticamente significativos. Resultados O estudo incluiu 1.557.901 pacientes; 40,23% eram homens e a média de idade foi de 51,7 (DP ± 17,6) anos. Durante um seguimento médio de 3,7 anos, a mortalidade foi de 3,35%. A prevalência de BAV foi de 1,38% (21.538). Os pacientes com BAV de primeiro, segundo e terceiro graus foram associados a uma taxa de sobrevida 24% (taxa de sobrevida relativa [RS] = 0,76; intervalo de confiança [IC] de 95%: 0,71 a 0,81; p < 0,001), 55% (RS = 0,45; IC de 95%: 0,27 a 0,77; p = 0,01) e 64% (RS = 0,36; IC de 95%: 0,26 a 0,49; p < 0,001) menor quando comparados ao grupo controle, respectivamente. Os pacientes com BAV 2:1 tiveram 79% (RS = 0,21; IC de 95%: 0,08 a 0,52; p = 0,005) menor taxa de sobrevida do que o grupo controle. Apenas Mobitz tipo I não foi associado a maior mortalidade (p = 0,27). Conclusão BAV foi um fator de risco independente para mortalidade geral, com exceção do BAV Mobitz tipo I.

Abstract Background Atrioventricular block (AVB) describes an impairment of conduction from the atria to the ventricles. Although the clinical course of AVB has been evaluated, the findings are from high-income countries and, therefore, cannot be extrapolated to the Latinx population. Objective Evaluate the association between AVB and mortality. Methods Patients from the CODE (Clinical Outcomes in Digital Electrocardiology) study, older than 16 years who underwent digital electrocardiogram (ECG) from 2010 to 2017 were included. ECGs were reported by cardiologists and by automated software. To assess the relationship between AVB and mortality, the log-normal model and the Kaplan-Meier curves were used with two-tailed p-values < 0.05 considered statistically significant. Results The study included 1,557,901 patients; 40.2% were men, and mean age was 51.7 (standard deviation ± 17.6) years. In a mean follow-up of 3.7 years, the mortality rate was 3.35%. The AVB prevalence was 1.38% (21,538). Patients with first-, second-, and third-degree AVB were associated with 24% (relative survival rate [RS] = 0.76; 95% confidence interval [CI]: 0.71-0.81; p < 0.001), 55% (RS = 0.45; 95% CI: 0.27-0.77; p = 0.01), and 64% (RS = 0.36; 95% CI: 0.26-0.49; p < 0.001) lower survival rate when compared to the control group, respectively. Patients with 2:1 AVB had 79% (RS = 0.21; 95% CI: 0.08-0.52; p = 0.005) lower survival rate than the control group. Only Mobitz type I was not associated with higher mortality (p = 0.27). Conclusion AVB was an independent risk factor for overall mortality, with the exception of Mobitz type I.

https://doi.org/10.36660/abc.20210763

Consumptive water use of banana under micro irrigation using a soil-water balance approximation
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Campos, Marcos S.

; Coelho, Eugenio F.

; Santos, Marcelo R. dos

; Fernandes, Rafael D. M.

; Cruz, Jailson L.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Ago 2022, Volume 26 Nº 8 Páginas 594 - 601

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A cobertura do solo contribui para a manutenção do teor de água do solo em níveis razoáveis para o crescimento da cultura. E influi na demanda hídrica da cultura e tempo de irrigação. O objetivo deste estudo foi estimar a evapotranspiração e a absorção de água radicular pela cultivar de bananeira ‘BRS Princesa’ através de uma abordagem simples utilizando alguns componentes do balanço hídrico do solo na zona radicular em solo nu e mulched irrigado por gotejamento e microaspersão. O delineamento experimental foi inteiramente casualizado em parcelas subdivididas com seis repetições. As parcelas consistiram de dois sistemas de irrigação (gotejamento e microaspersão), as subparcelas consistiram de duas condições de superfície do solo: com e sem cobertura morta. A aproximação alternativa para a percolação da água no solo pelo balanço hídrico permitiu obter ETc em condições de campo com razoável precisão. A ETc estimada a partir do balanço hídrico da zona radicular é menor que a ETc da equação FAO Penman-Monteith. A extração da água do solo pelo sistema radicular sob irrigação por gotejamento e com cobertura de biomassa da bananeira é maior do que a absorção sob irrigação por microaspersão.

ABSTRACT DMulching contributes to the maintenance of soil moisture at reasonable levels for crop growth. It influences the crop water demand and irrigation time. The aim of this study was to estimate evapotranspiration and root water uptake by the ‘BRS Princesa’ banana cultivar through a simple approach using some components of soil water balance within the root zone in bare and mulched soil irrigated by drip and micro sprinkler systems. The experimental design was completely randomized in split plots with six replicates. The plots consisted of two irrigation systems (drip and micro sprinkler), the subplots consisted of two soil surface conditions: with and without mulch. The alternative approach for soil water percolation in the soil water balance allowed obtaining ETc under field condition with reasonable accuracy. ETc estimated from the root zone water balance is lower than ETc from FAO Penman-Monteith equation. Root water extraction in the mulched soil under drip irrigation is higher than that under micro sprinkler irrigation.

https://doi.org/10.1590/1807-1929/agriambi.v26n8p594-601

Development of a Disposable Pipette Extraction Method Using Coffee Silverskin as an Adsorbent for Chromium Determination in Wastewater Samples by Solid Phase Extraction
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Silva, Weida R.

; Costa, Bruno E. S.

; Batista, Alex D.

; Alves, Vanessa N.

; Coelho, Nivia M. M.

Journal of the Brazilian Chemical Society

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Mai 2022, Volume 33 Nº 5 Páginas 498 - 507

Resumo: En | Texto: En | PDF: En

A procedure using disposable pipette tips adapted for solid-phase extraction, known as DPX SPE, was used as an alternative way for the chromium determination in wastewater samples. DPX-SPE consists of a device which allows a dynamic contact between the sample and the solid-phase. A residue obtained from the processing of coffee beans, denominate coffee silverskin, was used as a new adsorbent. Characterization techniques revealed properties of lignocellulosic materials with potential application for chromium adsorption. The parameters including adsorbent mass (25.00 mg), elution solvent (0.1 mol L-1 HCl, 200 μL) and pH (2.0) were optimized. Thus, 1.00 mL of deionized water for conditioning, 4.00 mL of sample, 2 extraction cycles and 1 elution cycle were the employed conditions. Enrichment factor of 12, limit of detection of 6.00 µg L-1 and relative standard deviation (RSD) 1.3% (n = 3) were obtained. The method proved to be fast, cheap, environmentally friendly, and simple, providing good recoveries (104-113%), and it was satisfactorily applied in real samples.

https://doi.org/10.21577/0103-5053.20210171

10.

ESTUDO DO PERFIL QUÍMICO DE CERVEJAS BRASILEIRAS: UMA AVALIAÇÃO ENTRE AS BEBIDAS ARTESANAIS E INDUSTRIAIS
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Coelho Neto, Dorval M.

; Moreira, Laysa L. P. F.

; Castro, Eustáquio V. R. de

; Souza, Warley B.

; Filgueiras, Paulo R.

; Romão, Wanderson

; Folli, Gabriely S.

; Lacerda Jr., Valdemar

Química Nova

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Mai 2022, Volume 45 Nº 5 Páginas 518 - 530

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Beer is commonly produced with four inputs: water, malt, hops, yeast and, in some cases, brewing adjuncts. Industrial and artisanal processes essentially follow the same steps and may undergo minor changes due to the style of beer. Despite this, many consumers attribute higher quality to craft beer compared to industrial ones. In this study, we applied the analytical techniques of infrared (IR), hydrogen nuclear magnetic resonance (1H NMR) and mass spectrometry (ESI(±)FT-ICR MS) to discriminate craft beers from industrial ones (brands common to the Brazilian market). In addition, Partial Least Squares (PLS) and Support Vector Machine (SVR) regression were used to estimate some beer properties (pH, total acidity (meq·L-1, color (EBC), bitterness (IBU), alcohol content (%v/v) and density (g·mL-1)). The use of the IR allowed the identification of vibrations attributed to chemical compounds common to beverages, such as water (3320 and 1640 cm-1), carbohydrates (1500 cm-1) and ethanol (1050-1040 and 875-865 cm-1). 1H NMR showed good applicability in identifying classes of organic compounds in the beverage, where signs attributed to alcohols, organic acids, carbohydrates and amino acids were observed. The ESI(+)FT-ICR MS allowed the identification of chemical compounds present in beverages, allowing the construction of a fingerprint of the beers. In addition, the application of chemometric tools enabled the prediction of physicochemical properties, presenting promising results in the prediction of alcohol content (RMSEC 0.2430 and RMSEP 0.3929) and bitterness (RMSEC 1.3022 and RMSEP 1.6008), and also in the classification regarding the manufacturing process (craft and industrial beer).

https://doi.org/10.21577/0100-4042.20170857

11.

Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
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Folquitto, Laís R. S.

; Souza, Thiago B. de

; Januario, Jaqueline P.

; Nascimento, Isadora M.

; Brandão, Brenda T. V.

; Moreira, Maria E. C.

; Horvath, Renato O.

; Santos, Marcelo H.

; Coelho, Luiz F. L.

; Veloso, Marcia P.

; Soares, Marisi G.

; Carvalho, Diogo T.

; Ionta, Marisa

; Chagas-Paula, Daniela A.

; Dias, Danielle F.

Journal of the Brazilian Chemical Society

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Abr 2022, Volume 33 Nº 4 Páginas 348 - 360

Resumo: En | Texto: En | PDF: En

Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding antiproliferative activity. All derivatives displayed in vivo anti-inflammatory activity. Among them, the substances 2’-hydroxy-4’-benzoylphenyl-β-D-glucopyranoside (4), 4-hydroxy-4’-methoxybenzophenone (5) and 4’-(4’’-methoxybenzoyl)phenyl-β-D-glucopyranoside (7) showed the best values of Glide Score in COX-2 docking evaluation and 4 and 5 selectively inhibited COX-2 and COX-1 in vitro enzymatic assay, respectively. Thus, 4 and 5 were tested against breast cancer (MCF-7, MDA MB-231, Hs578T) and non-small-cell-lung cancer (A549) cell lines. The estrogen-positive MCF-7 cell line was more responsive compared to other tested cell lines. They induced cell cycle arrest at G1/S transition in MCF-7 cell line once there was an increase in G0/G1 population with concomitant reduction of S population. The antiproliferative activity of these substances on MCF-7 was associated with their ability to inhibit cyclin E expression, a critical regulator of G1/S transition. Taken together, the data indicate that 4 and 5 have dual anti-inflammatory and antiproliferative activities and support further studies to evaluate their antitumor potential.

https://doi.org/10.21577/0103-5053.20210154

12.

Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series
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Clemente, Gleice

; Souza, Alexandre W. de

; Leão Filho, Hilton

; Coelho, Fernando M. A.

; Buchpiguel, Carlos

; Lima, Marcos

; Carneiro, Camila

; Pereira, Rosa M. R.

; Aikawa, Nadia

; Silva, Clovis A.

; Campos, Lucia M. A.

; Alves, Gabriel

; Astley, Camilla

; Gualano, Bruno

; Terreri, Maria Teresa

Advances in Rheumatology

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2022, Volume 62 elocation 28

Resumo: En | Texto: En | PDF: En

Abstract Background: The observation that 2-deoxy-2[18F]fluoro-D-glucose-positron emission tomography/magnetic resonance imaging ([18F]F-FDG-PET/MRI) revealed high-grade arterial wall FDG uptake, without arterial wall thickening with contrast-enhancement, in a considerable number of c-TA patients in our previous study, encouraged us to compare patients with both PET and MR angiography (MRA) positives, with those with PET positive but MRA negative. Our aim was to evaluate the relevance of these two imaging modalities together. Methods: A three-center cross-sectional study with 17 patients who fulfilled the EULAR/PRINTO/PReS criteria for c-TA and who underwent [18F]F-FDG-PET/MRI was previously performed. Herein we compared patients/vessels with positive PET (arterial wall 18F-FDG uptake higher than liver) and positive MRA (arterial wall thickening with contrast-enhancement)—group 1, with those with positive PET but negative MRA—group 2. Results: Median disease duration of 17 c-TA patients was 10.4 years. Nine patients were classified as group 1 and six as group 2. Median of metabolic inflammatory volume (MIV) of all arterial segments was significantly higher in group 1 (2346 vs. 1177 cm3; p = 0.036). Fifty-four (19%) from 284 available arterial segments presented positive findings in vessel wall in one or both images. Positive findings were concordant between PET and MRA in only 13% arterial segments (group 1); most changes (28–59.6%) that were discordant between both images, were positive in PET and negative in MRA (group 2). Conclusions: Our study demonstrated that [18F]F-FDG-PET/MRI added information about inflammation in vessel wall of c-TA patients. Prospective multicenter studies are needed in order to get solid data to guide immunosuppressive tapering and withdrawal.

https://doi.org/10.1186/s42358-022-00260-5

13.

COFFEE DRYER WITH DEHYDRATED AIR: A TECHNICAL AND ECONOMIC VIABILITY ANALYSIS
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Konopatzki, Evandro A.

; Christ, Divair

; Coelho, Silvia R. M.

; Demito, Angélica

; Werncke, Ivan

; Camicia, Rafaela G. da M.

Engenharia Agrícola

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2022, Volume 42 Nº 4 elocation e20210003

Resumo: En | Texto: En | PDF: En

ABSTRACT The defects that drying in concrete yards impose on coffee beans and the search for gourmet coffee production have prompted the emergence of new drying technologies. This work verified the technical and economic feasibility of drying coffee with dehumidified air with a refrigerating capacity of 422,908.7 J s-1, compatible with static capacity dryers equal to 75 m3. Considering the sale price of coffee, the cost of electric energy acquisition, the monthly interest rate and maintenance time, expenses that are equivalent to the depreciation of the concrete yard, a central compound rotational design was considered with 28 tests for the feasibility analysis, including the internal rate of return, net present value and the return on investment. The results showed that in the electric drying units, the dried coffee presents fewer broken and defective beans and has higher retention in a No. 17 sieve. With a higher beverage quality and a price 12.11% higher, drying with dehydrated air showed a PBD of 2.27 years and a return of US$ 2.49 million. The optimisation results were 98.98% desirable. It was concluded that it is economically feasible to dry coffee with dehydrated air and without using a concrete yard.

https://doi.org/10.1590/1809-4430-eng.agric.v42n4e20210003/2022

14.

Impacto da COVID-19 nos profissionais de saúde oral
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Romani, Jory G.

; Coelho, Margarida R.

; Pereira, Yolanda B.

; Viegas, Diogo M.

; Mexia, Rosário

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial

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Dez 2021, Volume 62 Nº 4 Páginas 246 - 253

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: O presente estudo teve como objetivo identificar o impacto físico, psicológico, social e económico da pandemia de COVID-19 no quotidiano dos profissionais de saúde oral em Portugal. Métodos: Foi realizado um estudo observacional e transversal, sob a forma de questionário on-line com 32 perguntas, através da plataforma Google Forms, sendo o link depois partilhado com os profissionais de saúde oral, em Portugal, via e-mail e redes sociais. Resultados: O presente questionário obteve 364 respostas. Relativamente ao impacto da COVID-19 na prática clínica, 48.1% dos profissionais reportou que o número de horas de trabalho diminuiu e cerca de 74% referiu uma diminuição do seu rendimento mensal. Quando questionados acerca da afluência de pacientes, 43% indicou que diminuiu. Cerca de 30% dos inquiridos assinalou que a situação atual tem afetado a qualidade dos tratamentos efetuados. Quanto ao impacto da COVID-19 na saúde física e mental, os participantes relataram um aumento do cansaço e dos níveis de stress/ansiedade. A grande maioria (74.2%) admitiu levar o stress do trabalho para casa. Por fim, 92,3% tem conhecimento e aplica as regras de remoção dos equipamentos de proteção individual. Conclusões: O presente estudo concluiu que a pandemia de COVID-19 teve um claro impacto psicológico, social, físico e económico nos profissionais de saúde oral em Portugal. Portanto, sugerimos que as instituições nacionais de saúde pública devem transmitir a confiança de que os consultórios dentários são ambientes seguros, como também devem ser criados mecanismos de apoio psicológico e financeiro para os profissionais mais afetados.

Abstract Objectives: The aim of this study was to identify the physical, psychological, social, and economic impact of the COVID-19 pandemic on the daily lives of oral health professionals in Portugal. Methods: A cross-sectional study was carried out in the form of an online questionnaire with 32 questions through Google Forms. The survey’s link was shared with oral health professionals in Portugal through institutional e-mail addresses and social networks. Results: The questionnaire obtained 364 responses. Regarding the impact of COVID-19 on clinical practice, 48.1% of professionals reported that the number of work hours decreased, and more than 74% reported a decrease in their monthly income. When asked about the affluence of patients, 43% indicated that it decreased. Approximately 30% of survey takers indicated that the current situation had affected the quality of the treatments carried out. As for the impact of COVID-19 on physical and mental health, the participants reported a considerable increase in tiredness and stress/anxiety levels. The vast majority (74%) admitted that they could not disconnect from work-related stress. Finally, 92.3% are aware and apply the directives for removing personal protective equipment. Conclusions: The present study concluded that the COVID-19 pandemic had a clear psychological, social, physical, and economic impact on oral health professionals in Portugal. Therefore, we believe that national public health institutions must transmit that dental practices are safe environments and create psychological and financial support mechanisms for the most affected professionals.

https://doi.org/10.24873/j.rpemd.2021.12.855 63 downloads

15.

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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Dez 2021, Volume 36 Nº 6 Páginas 725 - 735

Resumo: En | Texto: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

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