O presente trabalho relata um caso de criptococose pulmonar isolada em paciente com sintomas respiratórios, sem imunossupressão e sorologia negativa para o vírus da imunodeficiência humana, com massa pulmonar no radiograma de tórax. O diagnóstico foi confirmado pela biópsia transbrônquica e lavado broncoalveolar. A paciente recebeu tratamento ambulatorial com fluconazol, na dose de 300 mg/dia por seis meses, evoluindo com melhora clínica e regressão parcial da imagem radiológica. O presente caso ilustra uma apresentação não freqüente da criptococose pulmonar e faz considerações sobre a abordagem terapêutica com base na literatura.

In this study, we report a case of pulmonary cryptococcosis in a patient presenting respiratory symptoms and a lung mass on the chest X-ray. The patient had no concomitant diseases, was seronegative for human immunodeficiency virus and was not receiving immunosuppressive therapy of any kind. The diagnosis was confirmed through transbronchial biopsy and bronchoalveolar lavage. The patient was treated as an outpatient with fluconazole (300 mg/day for six months), evolving to clinical improvement and partial regression of the lung mass, as seen on a second chest X-ray. The current case illustrates an unusual presentation of pulmonary cryptococcosis and raises questions regarding the therapeutic approaches proposed in the literature.