Pesquisa | SciELO

ABSTRACT Copper is an essential element for beet; however, it needs to be made available in adequate quantities since this nutrient, which is a heavy metal, can cause toxicity to plants and/or humans. This study aimed to evaluate the agronomic performance of beet fertigated with copper in a semi-arid region of Brazil. Two experiments were carried out in complete randomized blocks, with five treatments (0, 1.5, 3.0, 4.0, and 6.0 kg ha-1 of copper) and four replicates. In 2019, the copper content was within the adequate range for beet. In 2021, fertigation with copper above 0.8 kg ha-1 led to contents in the phytotoxicity range, which may explain the reduction in total and tuberous root dry mass accumulation. Fertilization with copper increased marketable yield in 2019 (17.32 t ha-1 at the dose of 3.9 kg ha-1 of copper), while, in 2021, there was no fit of the equations. Copper fertilization altered the tuberous root pH but did not influence the other tuberous root quality components. Plants fertilized with copper accumulated more copper in the leaves than in the tuberous root, with a maximum accumulation of 6.0 kg ha-1 of copper in 2019 and 2021. Fertilization with 3.9 kg ha-1 suits soils with low copper content.

RESUMO O cobre é um elemento essencial à beterraba, no entanto, é necessário disponibilizá-lo em quantidade adequada uma vez que esse nutriente, que é um metal pesado, pode causar toxicidade às plantas e, ou, ao ser humano. Esta pesquisa teve como objetivo avaliar o desempenho agronômico de beterraba fertirrigada com cobre em uma região semiárida do Brasil. Foram conduzidos dois experimentos em delineados em blocos casualizados ao acaso, com cinco tratamentos (0, 1.5, 3.0, 4.5 e 6.0 kg ha-1 de cobre) e quatro repetições. Em 2019, o teor de cobre estava dentro da faixa adequada para a beterraba. Em 2021, a fertirrigação com cobre acima de 0.8 kg ha-1 proporcionou teores na faixa de fitotoxicidade, o que pode explicar a redução no acúmulo de massa seca total e de raízes tuberosas. A adubação com cobre aumentou a produtividade comercial em 2019 (17.32 t ha-1 na dose de 3.9 kg ha-1 de cobre) enquanto que, em 2021, não houve modelo ajustado. A adubação alterou o pH da raiz tuberosa, mas não influenciou nos demais atributos de qualidade pós-colheita da raiz tuberosa. Plantas adubadas com cobre acumularam mais cobre nas folhas do que na raiz tuberosa, com máxima acumulada em 2019 e em 2021, na dose 6.0 kg ha-1 de cobre. A adubação com 3.9 kg ha-1 é adequada para solos com baixo teor de cobre.

https://doi.org/10.1590/1807-1929/agriambi.v28n3e276908

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
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Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

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Out 2023, Volume 49 Nº 5 Páginas 580 - 589

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Economic indicators for cowpea cultivation under different irrigation depths
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Carvalho, Erika de O. T. de

; Costa, Deborah L. P.

; Luz, Denilson B. da

; Rua, Matheus L.

; Velame, Maria de L. A.

; Monteiro, Adrielle C.

; Vieira, Igor C. de O.

; Pinto, João V. de N.

; Fernandes, Gabriel S. T.

; Nunes, Hildo G. G. C.

; Souza, Paulo J. de O. P. de

; Santos, Marcos A. S. dos

Revista Brasileira de Engenharia Agrícola e Ambiental

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Ago 2023, Volume 27 Nº 8 Páginas 618 - 624

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Cowpeas are of high socioeconomic importance in the North and Northeast regions of Brazil, whereby the search for alternatives that offer increased productivity with financial returns has become an important challenge. Thus, the objective of this study was to estimate and evaluate the economic indicators of cowpea production in 2015 and 2016 when applying drip irrigation to different depths. Irrigation treatments were based on crop evapotranspiration (ETc). The experiment was laid in a randomized complete blocks design with four treatments (0, 25, 50, and 100% ETc) and six replications. For economic analysis, the results were extrapolated to an area of one hectare. Productivity in 2015 was lower than that in 2016; however, in all treatments, it was always higher when plants were grown under adequate water supply. In both years, the total operating costs were higher under irrigation than under rainfed conditions. The 100% ETc treatment resulted in a greater number of cowpea bags (60 kg) produced and a higher gross revenue than the rainfed treatment by 17 bags ha-1, equivalent to 1,020 kg ha-1 (gross revenue US$ 711.48) and 16 bags ha-1, equivalent to 960 kg ha-1 (gross revenue US$ 867.12), in 2015 and 2016, respectively. Water deficit limited cowpea yield in both years but made cultivation economically unfeasible only in 2015.

RESUMO O feijão-caupi apresenta grande importância socioeconômica nas regiões Norte e Nordeste do Brasil, sendo que a busca por alternativas que ofereçam aumento de produtividade com retorno financeiro tem se tornado um importante desafio. Assim, o objetivo deste trabalho foi estimar e avaliar os indicadores econômicos da produção de feijão-caupi nos anos de 2015 e 2016 quando da aplicação de irrigação por gotejamento em diferentes lâminas. Os tratamentos de irrigação foram baseados na evapotranspiração da cultura (ETc). O experimento foi instalado em blocos ao acaso com quatro tratamentos (0, 25, 50 e 100% da ETc) e seis repetições. Para análise econômica, os resultados foram extrapolados para uma área de um hectare. A produtividade em 2015 foi inferior à de 2016; porém, em todos os tratamentos, a produtividade foi sempre maior quando as plantas foram cultivadas sob irrigação adequada. Em ambos os anos, os custos operacionais totais foram maiores sob irrigação do que sob condições de sequeiro. O tratamento 100% ETc resultou em maior número de sacas de feijão-caupi (60 kg) produzidas e receita bruta superior ao tratamento de sequeiro em 17 sacas ha-1, equivalente a 1.020 kg ha-1 (receita bruta US$ 711,48) e 16 sacas ha-1, equivalente a 960 kg ha-1 (receita bruta US$ 867,12), em 2015 e 2016, respectivamente. A deficiência hídrica limitou a produtividade do feijão-caupi nos dois anos, mas inviabilizou economicamente o cultivo apenas em 2015.

https://doi.org/10.1590/1807-1929/agriambi.v27n8p618-624

Selection of desirable characters for papaya genetic improvement programs associated with hydric and thermal stress
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Costa, Taís F.

; Lopes, Beatriz G.

; Faria, Glaucia A.

; Ribeiro, Otavio A. P. da S.

; Suares-Rocha, Paula

; Lima, Juliana F. de

; Felizardo, Lucas M.

; Furlani Junior, Enes

Revista Brasileira de Engenharia Agrícola e Ambiental

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Mai 2023, Volume 27 Nº 5 Páginas 422 - 428

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Papaya cultivation is widespread in Brazil, particularly in the states of Bahia and Espírito Santo, where most commercial plantations are concentrated. Owing to the economic and social importance of papaya, the present study aimed to determine the explanatory variables between the genotypes of two cultivars: Golden (from the Soil group) and Tainung Nº 1 hybrid (from the Formosa group), cultivated under high temperatures and hydric stress. The genotypes containing more desirable agronomic characteristics were identified for use in plant genetic improvement programs. Principal component analysis (PCA) was applied to select the desirable genotypes for Golden and Tainung Nº 1 cultivars based on specific variables analyzed for two groups of variables; for group 1, the plant height, stem diameter, leaf length, leaf width, and leaf number were analyzed, whereas for group 2, the leaf and root dry mass, stem dry mass and fresh mass of 10 discs, fresh mass, and stem and root fresh mass were analyzed. When exposed to hydric and thermal stress, the Tainung Nº 1 cultivar outperformed the Golden cultivar for the evaluation characteristics selected for use in genetic improvement programs.

RESUMO No Brasil, o cultivo do mamão é difundido, principalmente nos estados da Bahia e Espírito Santo, onde se concentra a maior parte dos plantios comerciais. Devido à importância econômica e social do mamão, este estudo teve como objetivo determinar variáveis explicativas entre os genótipos de mamoeiro, cultivados sob altas temperaturas e condições de estresse hídrico, para definir quais contêm características agronômicas mais desejáveis para serem utilizadas em programas de melhoramento genético de plantas. Para isso, a análise de componentes principais foi aplicada para selecionar genótipos desejáveis para as cultivares Golden e Tainung Nº 1, com base em dois grupos de variáveis: grupo 1 - altura da planta, diâmetro do caule, comprimento da folha, largura da folha e número de folhas; e grupo 2 - massa seca da folha, massa seca da raiz, massa seca do caule, massa seca de 10 discos, massa fresca de 10 discos, massa fresca, massa fresca do caule e massa fresca da raiz. A cultivar Tainung Nº 1 do grupo Formosa apresentou vantagens em relação à cultivar Golden, quando submetida a condições de estresse hídrico e térmico para as características de avaliação sendo mais indicada para ser utilizada em programas de melhoramento genético.

https://doi.org/10.1590/1807-1929/agriambi.v27n5p422-428

Tecnografias líticas do Holoceno médio na região central da América do Sul: tesselas culturais para um mosaico paleo-histórico (primeira parte)
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Viana, Sibeli A.

; Ramos, Marcos Paulo de M.

; Carbonelli, Juan Pablo

; Costa, Kaira S. R.

Revista del Museo de Antropología

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Abr 2023, Volume 16 Nº 1 Páginas 317 - 338

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This work, subdivided into the first part and the second part, produced a technographic overview of the lithic material of middle Holocene sites, located in the central portion of South America, in the macro-region dominated by savannas in the lowlands of South America. This analysis was possible through reflection on available bibliographic information. The description of the modes of making lithic tools was based on the recognition of the three technical principles based on the techno-functional perspective: debitage, shaping and affordance; and on the considerations about relationship between the active and prehensive parts of the pieces (also called “techno-functional categories”). As a result, a synthesis of the technological peculiarities and variabilities was obtained in areas little known or documented with regard to the lithic materiality. In the first part of the article, this overview highlighted that there was, in the groupings of the sites of the Cratón Amazônico, a localized contribution to the relative technical cultures on the part of the principles of debitage and shaping, without being completely homogeneous. In reference to the management of raw materials, a local supply of lithic resources can be seen near these sites.

Resumen Este trabajo, subdividido em primera y segunda parte, presenta un panorama tecnográfico del material lítico proveniente de sitios del Holoceno medio, localizados en la región central de América del Sur, específicamente de la macro-región dominada por sabanas en las tierras bajas. Este análisis fue posible a través de una revisión y reflexión sobre la información bibliográfica disponible. En base a un enfoque tecno-funcional, la descripción de los modos de manufactura de útiles líticos se basó en el reconocimiento de tres principios técnicos desde el punto de vista tecno-funcional: débitage, façonnage y affordance, así como de la consideración de la relación entre las porciones activas y prehensivas de las piezas interpretadas como útiles (denominadas también “categorías tecno- funcionales”). Como resultado se obtuvo una síntesis de las particularidades y variabilidades tecnológicas en áreas poco conocidas o documentadas en lo que se refiere a la materialidad lítica. En la primera parte del artículo, esta síntesis puso en evidencia que en los agrupamientos de los sitios del Cratón Amazónico existió un conjunto de culturas tecnicas relativamente homogéneas concentradas alrededor de los principios de débitage y façonnage. En cuanto a la gestión de la materia prima, se observa en estos sitios un aprovisionamiento local de recursos líticos.

https://doi.org/10.31048/1852.4826.v16.n1.38770

Tecnografias líticas do Holoceno médio na região central da América do Sul: tesselas culturais para um mosaico paleo-histórico (segunda parte)
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Ramos, Marcos Paulo de M.

; Carbonelli, Juan Pablo

; Viana, Sibeli A.

; Costa, Kaira S. R.

Revista del Museo de Antropología

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Abr 2023, Volume 16 Nº 1 Páginas 339 - 358

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This article constitutes the second part of the lithic technographic analysis of Middle Holocene sites in a vast macro-region, the central portion of South America: it includes the groups of sites B, C and D. A common element in all the analyzed sets is the presence of the techno-functional category B tools. In reference to the production mode, it is observed that the principle of debitage predominates in the area of analysis. However, its application was diverse; there are assemblages in which there was a predetermination about the making of flakes, others in which the cores were reintroduced as blanks or presented edges and there are other places in which façonnage confection flakes were reintroduced as blanks for tools. Other production principles have also been recorded: the principles of affordance (both in the exclusive productional expression and in its productional and functional expression) and shaping are observed in sites in groups A, C and D. Recognizing the different production modes is the starting point for thinking about how groups with different technical traditions have occupied different spaces in the region.

Resumen Este artículo conforma la segunda parte del análisis de las tecnografías líticas de los sitios del Holoceno medio en una extensa macrorregión, el sector central de América del Sur: abarca los agrupamientos B, C y D de los sitios. Un elemento común en todos los conjuntos analizados en la presencia de herramientas de la categoría tecno-funcional B. En referencia a los modos de producción se observa que el principio de debitagem predomina en el área de análisis. No obstante su aplicación es diversa; hay conjuntos donde existió una predeterminación sobre la confección de lascas, otros donde los núcleos son reintroducidos como soportes o presentando filos y otros sitios en donde se reintrodujeron lascas de confección de façonage como herramientas de soporte. El resto de los principios de producción también fueron registrados: el de afordancia (tanto en la producción instrumental como en su expresión produccional) y el de façonage se observan en sitios de los agrupamientos A, C y D. El reconocimiento de los diferentes modos de producción, es el punto de inicio para pensar como grupos con tradiciones técnicas diferentes, ocuparon espacios diversos en la región.

https://doi.org/10.31048/1852.4826.v16.n1.38769

Results of endoscopic biliary drainage in patients with malignant hilar stricture
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Martins, Bruno Costa

; Perez, Caio A.

; Ruas, Jennifer N.

; Bento, Luiza H.

; Mendonça, Ernesto Q.

; Paulo, Gustavo A. de

; Uemura, Ricardo S.

; Geiger, Sebastian N.

; Lima, Marcelo Simas de

; Jukemura, Jose

; Ribeiro Jr., Ulysses

; Maluf Filho, Fauze

Clinics

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2023, Volume 78 elocation 100153

Resumo: En | Texto: En | PDF: En

Abstract In Malignant Hilar Biliary Stricture (MHBS) palliative biliary drainage is a frequent strategy, improving the quality of life, reducing pruritus, loss of appetite and relieving cholangitis. The endoscopic approach is an effective, although challenging procedure. This study aimed to evaluate technical and clinical success rates of biliary drainage by ERCP. This is a retrospective study including all patients with MHBS referred to Instituto do Cancer do Hospital de São Paulo (ICESP) submitted to biliary drainage by ERCP, between January 2010 and December 2017. Multivariable logistic regression was performed to evaluate predictors of clinical failure, as total bilirubin levels, Bismuth classification, number of hepatic sectors drained and presence of cholangitis. In total, 82 patients presenting unresectable MHBS were included in this study. 58.5% female and 41.5% male, with a mean age of 60±13 years. Bismuth classification grades II, IIIA, IIIB and IV were noted in 23.2%, 15.9%, 14.6% and 46.3%, respectively. Technical and clinical success was achieved in 92.7% and 53.7% respectively. At multivariable logistic-regression analyses, Bismuth IV strictures were related to higher clinical failure rates when compared to other strictures levels, with an Odds Ratio of 5.8 (95% CI 1.28‒20.88). In conclusion, endoscopic biliary drainage for malignant hilar biliary stricture had a high technical success but suboptimal clinical success rate. Proximal strictures (Bismuth IV) were associated with poor drainage outcomes.

https://doi.org/10.1016/j.clinsp.2022.100153

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Supl. 3 elocation e23022

Resumo: En | Texto: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

Empresas e ditadura civil-militar brasileira: os editoriais do jornal Folha de S. Paulo em uma perspectiva histórica
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Santos, Cynthia Adrielle da Silva

; Costa, Alessandra

Cadernos EBAPE.BR

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Out 2022, Volume 20 Nº 5 Páginas 688 - 707

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Em alinhamento com os estudos organizacionais históricos (Decker, Hassard, & Rowlinson, 2021; Maclean, Harvey, & Clegg, 2016) e buscando uma reorientação geográfica mais ao sul global, no foco nas pesquisas históricas e em estudos organizacionais e de gestão (A. S. M. Costa & Wanderley, 2021; Wanderley & A. Barros, 2019), este artigo tem como objetivo compreender o posicionamento ideológico e a atuação político-discursiva do jornal Folha de S. Paulo no período inicial da ditadura civil-militar brasileira (1964-1985). Para tanto, construiu-se um referencial teórico sustentado por duas correntes historiográficas (Empresariado e Ditadura; História e Imprensa) e pelos conceitos de discurso, ideologia e poder articulados pela análise crítica de discurso. Em termos de fontes documentais, foram coletados 112 editoriais diários, publicados de janeiro a junho de 1964 e disponíveis no arquivo histórico da empresa pesquisada. Para a realização da análise dos dados coletados, foram utilizados o aporte teórico-metodológico do modelo tridimensional de Norman Fairclough (2016) e a sua proposta de utilização do modelo de análise de estratégias de construções ideológicas de J. B. Thompson (2011). Como resultado, foi possível identificar três momentos na trajetória de construção discursiva do jornal Folha de S. Paulo em relação ao golpe militar de 1964 no Brasil: 1) significativa contribuição para a desestabilização do governo democrático do presidente João Goulart; 2) forte alinhamento com o golpe militar e seus desdobramentos imediatos; e 3) apoio ao posterior governo Castelo Branco, mas já com a enunciação de algumas ressalvas. Por fim, é possível afirmar que essa organização jornalística atuou fortemente não apenas como instrumento de informação, mas, principalmente, como produtora e reprodutora de discursos específicos em prol de determinado grupo social e de seus atos ditatoriais subsequentes. Diante desse quadro, tornam-se cada vez mais necessárias pesquisas históricas sobre as relações políticas e socioeconômicas entre empresas, governo e sociedade ao longo do tempo e seus desdobramentos na atualidade.

Abstract In alignment with historical organizational studies (Decker, Hassard, & Rowlinson, 2021; Maclean, Harvey, & Clegg, 2016) and seeking a geographical (re)orientation, more to the Global South, to historical research in organizational and management studies (A. S. M. Costa & Wanderley, 2021; Wanderley & A. Barros, 2019), the article aims to understand the ideological positioning and the political-discursive performance of the newspaper Folha de S. Paulo in the early period of the Brazilian civil-military dictatorship (1964-1985). A theoretical framework was built, supported by two historiographical currents (Business and Dictatorship; History and Press) and by the concepts of discourse, ideology, and power articulated by critical discourse analysis. In terms of documental sources, 112 daily editorials were collected, published from January to June 1964, and available in the historical archive of the researched company. The theoretical and methodological contribution of Norman Fairclough’s (2016) three-dimensional model and its proposed use by J.B. Thompson’s (2011) model of analysis of strategies of ideological constructions were used. As a result, it was possible to identify three different moments in the discursive trajectory of the positioning of the Folha de S. Paulo newspaper concerning the military coup of 1964 in Brazil: (1) significant contribution to the destabilization of the democratic government of President João Goulart, (2) strong alignment with the military coup and its immediate unfoldings; and (3) support for the subsequent Castelo Branco government, but already with the enunciation of some reservations. Finally, it is possible to affirm that this journalistic organization acted strongly not only as an instrument of information but mainly as a producer and reproducer of specific discourses in favor of a particular social group and its subsequent dictatorial acts. Against this background, historical research into the political and socio-economic relations between business, government, and society over time and their unfolding today is becoming increasingly necessary.

Resumen En consonancia con los estudios organizativos históricos (Decker, Hassard, & Rowlinson, 2021; Maclean, Harvey, & Clegg, 2016) y buscando una reorientación geográfica más hacia el Sur global, en el enfoque de la investigación histórica y en los estudios organizativos y de gestión (A. S. M. Costa & Wanderley, 2021; Wanderley & A. Barros, 2019), el artículo pretende comprender el posicionamiento ideológico y la actuación político-discursiva del periódico Folha de S. Paulo en el período inicial de la dictadura cívico-militar brasileña (1964-1985). Para ello, se construyó un marco teórico apoyado en dos corrientes historiográficas (Empresariado y Dictadura e Historia y Prensa) y en los conceptos de discurso, ideología y poder articulados por el análisis crítico del discurso. En cuanto a las fuentes documentales, se recogieron 112 editoriales diarios, publicados de enero a junio de 1964 y disponibles en el archivo histórico de la empresa investigada. Para llevar a cabo el análisis de los datos recogidos, se utilizó el aporte teórico y metodológico del modelo tridimensional de Norman Fairclough (2016) y su propuesta de uso del modelo de análisis de estrategias de construcciones ideológicas de J.B. Thompson (2011). Como resultado, fue posible identificar tres momentos en la trayectoria discursiva del periódico Folha de S. Paulo en relación con el golpe militar de 1964 en Brasil: (1) contribución significativa a la desestabilización del gobierno democrático del presidente João Goulart, (2) fuerte alineamiento con el golpe militar y sus desdoblamientos inmediatos; y (3) apoyo al posterior gobierno de Castelo Branco, pero ya con la enunciación de algunas salvedades. Finalmente, es posible afirmar que esta organización periodística actuó fuertemente no sólo como instrumento de información, sino principalmente como productora y reproductora de discursos específicos a favor de un determinado grupo social y sus subsiguientes actos dictatoriales. En este contexto, la investigación histórica sobre las relaciones políticas y socioeconómicas entre las empresas, el gobierno y la sociedad a lo largo del tiempo y su desarrollo en la actualidad es cada vez más necesaria.

https://doi.org/10.1590/1679-395120210181

10.

CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
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Costa, Edna M. A.

; Carrão, Daniel B.

; Bucci, Jade L. M.

; Oliveira, Anderson R. M.

; Machado, Tallita M.

; Ferreira, Vitor F.

; Lima, Émerson S.

; Vasconcellos, Marne C.

; Magalhães, Igor R. S.

Journal of the Brazilian Chemical Society

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Out 2022, Volume 33 Nº 10 Páginas 1145 - 1153

Resumo: En | Texto: En | PDF: En

CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, this molecule is a relevant candidate for drug development, but there is still no information on its human metabolism and systemic elimination. This study aimed to investigate the in vitro metabolism of this naphthoquinone by human liver microsomes. Initially, in order to determine the in vitro enzymatic kinetic parameters, a high performance liquid chromatography (HPLC) method to quantify the CNFD was developed and validated. In addition, the enzymatic kinetic data, the predicted pharmacokinetic in vivo parameters and the phenotyping study were presented. The main metabolism sites and metabolites have been suggested in silico. The developed HPLC method was linear, reproducible, selective, accurate, and stable. The enzymatic kinetic parameters revealed a sigmoidal profile. In vitro to in vivo extrapolation hepatic metabolic clearance was 10.39 mL min-1 kg-1 protein and the liver extraction rate was 51%. The clearance in vivo associated with a hepatic extraction ratio indicates that the hepatic metabolism is the main route of elimination. Although all cytochrome P450 enzymes evaluated metabolized CNFD, CYP2C9 and CYP3A4 showed higher metabolic capacity. For the first time, metabolism studies of CNFD were demonstrated.

https://doi.org/10.21577/0103-5053.20220034

11.

REDGIM COMO APLICATIVO DE SMARTPHONE PARA APLICAÇÕES QUIMIOMÉTRICAS POR MEIO DE ANÁLISE DE IMAGENS: UM USO EM PLS
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Rosa, Thalles R.

; Siqueira, Bruno M. M.

; Costa, Rayana A.

; Reis, Jadson Z. dos

; Pacheco, Wagner L. S.

; Moura, Paulo R. G. de

; Romão, Wanderson

; Filgueiras, Paulo R.

Química Nova

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Mai 2022, Volume 45 Nº 5 Páginas 550 - 559

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

The study of the spectrum of light has increased its range of action in the field of chemistry, with the help of several advanced equipment and innovative techniques that have become a strong ally of analytical chemistry. However, the simplicity of obtaining results integrated with mobile devices appears as an interesting path to be taken in the field of chemical analysis. This work addresses the dissemination of an application called REDGIM for smartphones on the Android platform capable of working with multivariate image analysis using chemometric methods through the luminous intensities of photos and R (red), G (green) and B (blue) channels. In order to show the potential of REDGIM, we propose two applications using the partial least squares (PLS) regression method: 1) quantification of free chlorine in tap water; and 2) quantification of cannabinol, (CBN, a type of cannabinoid) in marijuana and hashish samples. The free chlorine concentration obtained for two investigated samples was 0.73 and 0.74 mg L-1 and 0.74 and 0.76 mg L-1 by the spectrophotometer and by the application (container: cuvette), respectively. For the quantification of CBN in marijuana and hashish samples, the mean concentration ranged from 6.137 to 8.823 mg mL-1. The results obtained by the application are compatible with results from traditional techniques, such as UV-Vis spectrophotometry, for example. Therefore, REDGIM was proved to be a simple and accessible technological tool for the scientific community, being viable for chemical tests of a multivariate nature.

https://doi.org/10.21577/0100-4042.20170861

12.

Emerging titanium surface modifications: The war against polymicrobial infections on dental implants
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Barão, Valentim A. R.

; Costa, Raphael C.

; Shibli, Jamil A.

; Bertolini, Martinna

; Souza, João Gabriel S.

Brazilian Dental Journal

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Fev 2022, Volume 33 Nº 1 Páginas 1 - 12

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Implantes dentários em titânio (Ti) são reconhecidos como principal modalidade terapêutica para a reabilitação oral de pacientes edêntulos, demonstrando uma alta taxa de sucesso e longevidade clínica. No entanto, após inserção no ambiente bucal, os implantes dentários agem como substrato para adesão e acúmulo microbiano. A formação de biofilmes em implantes dentários tem sido considerada o principal fator etiológico para induzir doenças inflamatórias conhecidas como mucosite peri-implantar e peri-implantite, sendo está última reconhecida como principal razão para falha tardia dos implantes dentários. Diferentes fatores têm sido atribuídos por promover o acúmulo microbiano em implantes dentários, levando a uma mudança microbiológica e favorecendo o dano tecidual, como a matriz do biofilme, exposição a carboidratos e interação entre reinos. Esses fatores combinados com a organização espacial de biofilmes, reduzida suscetibilidade microbiana, complexa composição microbiológica e a superfície irregular dos implantes dificultam o controle do biofilme e a morte microbiana. Apesar da etiologia bem conhecida, ainda não há consenso sobre o melhor protocolo clínico para controlar o acúmulo microbiano nas superfícies dos implantes dentários e tratar a doença peri-implantar. Nesse sentido, diferentes coberturas e tratamentos de superfície no Ti têm sido desenvolvidos objetivando a redução dos níveis microbianos e o controle das infecções polimicrobianas em implantes. Portanto, essa revisão crítica objetiva discutir a atual evidência em relação ao acúmulo de biofilmes em implantes dentários e fatores chave relacionados ao processo patogênico das infecções peri-implantares. Além disso, o potencial de alterações de superfícies com propriedades antimicrobianas para implantes dentários é discutido para ressaltar futuras estratégias promissoras no controle da peri-implantite.

Abstract Dental implants made of titanium (Ti) material is recognized as the leading treatment option for edentulous patients’ rehabilitation, showing a high success rate and clinical longevity. However, dental implant surface acts as a platform for microbial adhesion and accumulation once exposed to the oral cavity. Biofilm formation on implant surfaces has been considered the main etiologic factor to induce inflammatory diseases, known as peri-implant mucositis and peri-implantitis; the latter being recognized as the key reason for late dental implant failure. Different factors, such as biofilm matrix production, source of carbohydrate exposure, and cross-kingdom interactions, have encouraged increased microbial accumulation on dental implants, leading to a microbiological community shift from a healthy to a pathogenic state, increasing inflammation and favoring tissue damage. These factors combined with the spatial organization of biofilms, reduced antimicrobial susceptibility, complex microbiological composition, and the irregular topography of implants hamper biofilm control and microbial killing. In spite of the well-known etiology, there is still no consensus regarding the best clinical protocol to control microbial accumulation on dental implant surfaces and treat peri-implant disease. In this sense, different coatings and Ti surface treatments have been proposed in order to reduce microbial loads and control polymicrobial infections on implantable devices. Therefore, this critical review aims to discuss the current evidence on biofilm accumulation on dental implants and central factors related to the pathogenesis process of implant-related infections. Moreover, the potential surface modifications with anti-biofilm properties for dental implant devices is discussed to shed light on further promising strategies to control peri-implantitis.

https://doi.org/10.1590/0103-6440202204860

13.

Biosurfactants: Sustainable and Versatile Molecules
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Barbosa, Fernanda G.

; Ribeaux, Daylin R.

; Rocha, Thiago

; Costa, Rogger A. M.

; Guzmán, Ramiro R.

; Marcelino, Paulo R. F.

; Lacerda, Talita M.

; Silva, Silvio S. da

Journal of the Brazilian Chemical Society

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2022, Volume 33 Nº 8 Páginas 870 - 893

Resumo: En | Texto: En | PDF: En

Biosurfactants are amphipathic molecules produced by plants, animals, and microorganisms, that present emulsifying properties and may act reducing surface and interfacial tensions. When compared to synthetic surfactants, these biological analogues have high biodegradability potential, and may be produced from renewable raw materials within overall biotechnological processes involving low generation of residues. The production and application of microbial surfactants have been recently considered in several industrial sectors, as these low toxicity versatile compounds find applications in food, pharmaceutical, cosmetic, and petrochemical products, in nanotechnology and agriculture, and in the bioremediation of xenobiotic-contaminated areas. Herein, the main conceptual aspects and physicochemical properties, as well as the classifications of biosurfactants according to their origin and their chemical structures, are addressed. The production of microbial biosurfactants through sustainable processes are also described, with particular focus on new applications and on the increasing relevance of such bioproducts for the sustainable development of modern society.

https://doi.org/10.21577/0103-5053.20220074

14.

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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Dez 2021, Volume 36 Nº 6 Páginas 725 - 735

Resumo: En | Texto: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

15.

Diagnóstico de Fibrilação Atrial na Comunidade Utilizando Eletrocardiograma e Autorrelato: Análise Transversal do ELSA-Brasil
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Santos, Itamar S.

; Lotufo, Paulo A.

; Brant, Luisa

; Pinto Filho, Marcelo M.

; Pereira, Alexandre da Costa

; Barreto, Sandhi Maria

; Ribeiro, Antonio L.

; Thomas, G Neil

; Lip, Gregory Y. H.

; Bensenor, Isabela M.

Arquivos Brasileiros de Cardiologia

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Set 2021, Volume 117 Nº 3 Páginas 426 - 434

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A fibrilação ou flutter atrial (FFA) é a arritmia cardíaca sustentada mais comum. Existem poucos dados sobre a epidemiologia da FFA na América do Sul. Objetivo: O presente estudo procurou descrever a epidemiologia clínica da FFA e o uso de anticoagulantes na avaliação da linha de base do Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil). Métodos: Foram analisados dados de 13.260 participantes do ELSA-Brasil. A FFA foi definida pelo eletrocardiograma ou por autorrelato. Modelos de regressão logística foram construídos para analisar fatores associados à FFA. Este estudo também analisou se idade e sexo estavam associados ao uso de anticoagulantes para evitar acidente vascular cerebral. O nível de significância foi de 5%. Resultados: A idade mediana foi de 51 anos, e 7.213 (54,4%) participantes eram mulheres. A FFA foi detectada em 333 (2,5%) participantes. O aumento da idade (razão de chances [RC]:1,05; intervalo de confiança de 95% [IC95%]: 1,04-1,07), hipertensão (RC:1,44; IC95%:1,14-1,81) coronariopatia (RC: 5,11; IC95%:3,85–6,79), insuficiência cardíaca (RC:7,37; IC95%:5,00–10,87) e febre reumática (RC:3,38; IC95%:2,28–5,02) foram associadas à FFA. Dos 185 participantes com FFA e pontuação no CHA2DS2-VASc≥2, apenas 20 (10,8%) usavam anticoagulantes (50,0% entre aqueles com FFA no eletrocardiograma de linha de base). O uso de anticoagulantes nesse grupo foi associado a maior idade (1,8% vs 17,7% naqueles com idade ≤ 54 e ≥ 65 anos, respectivamente; p=0,013). Observou-se uma tendência ao menor uso de anticoagulantes em mulheres (7,1% vs. 16,4% em mulheres e homens, respectivamente; p=0,055). Conclusões: No recrutamento do ELSA-Brasil, 2,5% dos participantes tinham FFA. O baixo uso de anticoagulantes era comum, o que representa um desafio para os cuidados de saúde nesse cenário.

Abstract Background: Atrial fibrillation or flutter (AFF) is the most common sustained cardiac arrhythmia. Limited data can be found on AFF epidemiology in South America. Objective: The present study sought to describe the clinical epidemiology of AFF and the use of stroke prevention medication in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Methods: This study analyzed data from 13,260 ELSA-Brasil participants. AFF was defined according to ECG recording or by self-report. Logistic regression models were built to analyze factors associated with AFF. This study also analyzed if age and sex were associated with anticoagulant use for stroke prevention. Significance level was set at 5%. Results: Median age was 51 years and 7,213 (54.4%) participants were women. AFF was present in 333 (2.5%) participants. Increasing age (odds ratio [OR]:1.05; 95% confidence interval [95%CI]: 1.04–1.07), hypertension (OR:1.44; 95%CI: 1.14–1.81), coronary heart disease (OR: 5.11; 95%CI: 3.85–6.79), heart failure (OR:7.37; 95%CI: 5.00–10.87), and rheumatic fever (OR:3.38; 95%CI: 2.28–5.02) were associated with AFF. From 185 participants with AFF and a CHA2DS2-VASc score ≥2, only 20 (10.8%) used anticoagulants (50.0% among those with AFF in the baseline ECG). Stroke prevention in this group was associated with a higher age (1.8% vs 17.7% in those aged ≤ 54 and ≥ 65 years, respectively; p=0.013). A trend towards a reduced anticoagulant use was observed in women (7.1% vs. 16.4% in women and men, respectively; p=0.055). Conclusions: At the ELSA-Brasil baseline, 2.5% of the participants had AFF. The lack of stroke prevention was common, which is an especially challenging point for healthcare in this setting.

https://doi.org/10.36660/abc.20190873 193 downloads

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