Pesquisa | SciELO

OBJECTIVES: With the declining numbers of coronavirus disease 2019 (COVID-19) cases in the state of São Paulo, Brazil, social distancing measures have gradually been lifted. However, the risk of a surge in the number of cases cannot be overlooked. Even with the adoption of nonpharmaceutical interventions, such as restrictions on mass gatherings, wearing of masks, and complete or partial closure of schools, other public health measures may help control the epidemic. We aimed to evaluate the impact of the contact tracing of symptomatic individuals on the COVID-19 epidemic regardless of the use of diagnostic testing. METHODS: We developed a mathematical model that includes isolation of symptomatic individuals and tracing of contacts to assess the effects of the contact tracing of symptomatic individuals on the COVID-19 epidemic in the state of São Paulo. RESULTS: For a selection efficacy (proportion of isolated contacts who are infected) of 80%, cases and deaths may be reduced by 80% after 60 days when 5000 symptomatic individuals are isolated per day, each of them together with 10 contacts. On the other hand, for a selection efficacy of 20%, the number of cases and deaths may be reduced by approximately 40% and 50%, respectively, compared with the scenario in which no contact-tracing strategy is implemented. CONCLUSION: Contact tracing of symptomatic individuals may potentially be an alternative strategy when the number of diagnostic tests available is not sufficient for massive testing.

https://doi.org/10.6061/clinics/2021/e2639 416 downloads

Morphoanatomical and histochemical studies of the seed development of Euterpe oleracea (Arecaceae)
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Pereira, João Alves Ferreira

; Coutinho, Ítalo Antônio Cotta

; Soares, Emanoella Lima

; Soares, Arlete Aparecida

; Caetano, Ana Paula de Souza

; Campos, Francisco de Assis de Paiva

Rodriguésia

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2021, Volume 72 elocation e01832019

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Embora o consumo de açaí (Euterpe oleracea) seja há tempos um importante componente da dieta dos povos amazônicos, o açaizeiro tem recentemente atraído tanto o interesse econômico quanto científico devido à presença de urna vasta gama de compostos bioativos encontrados no pericarpo de seus frutos. As sementes de açaí representam o principal subproduto após a extração da polpa e podem ser potencialmente utilizadas para a produção de etanol, mas esse processo é dificultado pelo conhecimento limitado sobre a biología das sementes, sua composição química e a deposição de reserva de padrões durante o desenvolvimento das sementes. O objetivo deste trabalho é descrever o desenvolvimento morfoanatômico das sementes, bem como identificar os principais compostos orgânicos armazenados nas sementes. Para atingir esse objetivo, foram realizadas análises histológicas e histoquímicas das sementes em desenvolvimento. Os resultados revelaram que a semente é albuminosa, bitegmica e que tegumento interno da semente dá origem as ruminações do endosperma. Além disso, os resultados indicam que as reservas nutritivas das sementes de açaí são encontradas nas paredes celulares espessadas pelo endosperma na forma de polissacarídeos de reserva. Nossas descobertas fornecem informações úteis para futuros estudos sobre biología reprodutiva, propagação e melhoria de uma cultura tao lucrativa.

Abstract Although the consumption of açaí (Euterpe oleracea) pulp has long been an important component of the diet of the peoples from the Amazon, the açaí palm tree has recently attracted economic and scientific interest because of its vast array of bioactive compounds found in the fruit pericarp. The açaí seeds are the largest byproduct after pulp extraction and have potential for use in ethanol production, but this process is hindered by limited knowledge of seed biology, chemical composition and pattern reserve deposition during seed development. The aim of this work was to describe the morphoanatomical development of the seeds, as well as to identify the main organic compounds stored in the seeds. To achieve this goal, histological and histochemical analyses were performed on developing seeds. Results showed the seed is albuminous, bitegmic and that ingrowths of the seed coat give rise to a ruminate endosperm. Moreover, the nutritive reserves of açaí seeds are found in the endosperm thickened cell walls as reserve polysaccharides. Our findings provide information for future studies dealing with reproductive biology, propagation and the improvement of this profitable crop.

https://doi.org/10.1590/2175-7860202172048 171 downloads

Effectiveness of first-wave protease inhibitors in hepatitis C virus genotype 1 infection: a multicenter study in Brazil
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Lobato, Cirley Maria de Oliveira

; Balassiano, Natalia

; Hyppolito, Elodie Bomfim

; Sanchez-Lermen, Rafaela Liz Pellegrim

; Signorelli, Izabelle Venturini

; Nicacio, Miguel Yasuo Tomita

; Firmino Filho, Alberto Pereira

; Andrade, Thais Guaraná de

; Lima, José Milton de Castro

; Arruda, Talita Amorim de

; Coutinho, Fernanda Schwanz

; Araujo, Everton Felipe do Vale

; Esmeraldo, Ticiana Mota

; Cortez, Erlon

; Capeli, Rafaela Lorenzon Aragão

; Matos, Melquior Brunno Mateus de

; Pessoa, Francisco Sérgio Rangel

; Oliveira, Hélder Cássio de

; Arruda, Érico Antônio Gomes de

; Gonçalves, Patrícia Lofêgo

; Araújo Filho, Antônio Haroldo

; Esberard, Eliane Bordalo Cathalá

; Souto, Francisco José Dutra

Revista da Sociedade Brasileira de Medicina Tropical

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Fev 2018, Volume 51 Nº 1 Páginas 14 - 20

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: In 2013, combination therapy using peginterferon, ribavirin, and boceprevir or telaprevir was introduced to treat hepatitis C virus genotype 1 infection in Brazil. The effectiveness of this therapy in four Brazilian regions was evaluated. METHODS: Clinical and virological data were obtained from patients of public health institutions in five cities, including sustained virological response (SVR) and side effects. Patients with advanced fibrosis (F3/4), moderate fibrosis (F2) for > 3 years, or extra-hepatic manifestations were treated according to Ministry of Health protocol. Treatment effectiveness was verified by using bivariate and multivariate analysis; p-values of < 0.05 were considered significant. RESULTS: Of 275 patients (64.7% men; average age, 57 years old), most (61.8%) were treatment-experienced; 53.9% had subgenotype 1a infection, 85.1% had advanced fibrosis, and 85.5% were treated with telaprevir. SVR was observed in 54.2%. Rapid virological response (RVR) was observed in 54.6% of patients (data available for 251 patients). Overall, 87.5% reported side effects and 42.5% did not complete treatment. Skin rash, severe infection, and death occurred in 17.8%, 2.5%, and death in 1.4% of cases, respectively. SVR was associated with treatment completion, RVR, and anemia. CONCLUSIONS: The effectiveness of hepatitis C virus triple therapy was lower than that reported in phase III clinical trials, possibly owing to the prioritized treatment of patients with advanced liver fibrosis. The high frequency of side effects and treatment interruptions observed supported the decision of the Brazilian authorities to suspend its use when safer and more effective drugs became available in 2015.

https://doi.org/10.1590/0037-8682-0279-2017 1312 downloads

Overactive bladder – 18 years – Part II
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Truzzi, Jose Carlos

; Gomes, Cristiano Mendes

; Bezerra, Carlos A.

; Plata, Ivan Mauricio

; Campos, Jose

; Garrido, Gustavo Luis

; Almeida, Fernando G.

; Averbeck, Marcio Augusto

; Fornari, Alexandre

; Salazar, Anibal

; Dell’Oro, Arturo

; Cintra, Caio

; Sacomani, Carlos Alberto Ricetto

; Tapia, Juan Pablo

; Brambila, Eduardo

; Longo, Emilio Miguel

; Rocha, Flavio Trigo

; Coutinho, Francisco

; Favre, Gabriel

; Garcia, José Antonio

; Castaño, Juan

; Reyes, Miguel

; Leyton, Rodrigo Eugenio

; Ferreira, Ruiter Silva

; Duran, Sergio

; López, Vanda

; Reges, Ricardo

International braz j urol

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Abr 2016, Volume 42 Nº 2 Páginas 199 - 214

Resumo: En | Texto: En | PDF: En

ABSTRACT Traditionally, the treatment of overactive bladder syndrome has been based on the use of oral medications with the purpose of reestablishing the detrusor stability. The recent better understanding of the urothelial physiology fostered conceptual changes, and the oral anticholinergics – pillars of the overactive bladder pharmacotherapy – started to be not only recognized for their properties of inhibiting the detrusor contractile activity, but also their action on the bladder afference, and therefore, on the reduction of the symptoms that constitute the syndrome. Beta-adrenergic agonists, which were recently added to the list of drugs for the treatment of overactive bladder, still wait for a definitive positioning – as either a second-line therapy or an adjuvant to oral anticholinergics. Conservative treatment failure, whether due to unsatisfactory results or the presence of adverse side effects, define it as refractory overactive bladder. In this context, the intravesical injection of botulinum toxin type A emerged as an effective option for the existing gap between the primary measures and more complex procedures such as bladder augmentation. Sacral neuromodulation, described three decades ago, had its indication reinforced in this overactive bladder era. Likewise, the electric stimulation of the tibial nerve is now a minimally invasive alternative to treat those with refractory overactive bladder. The results of the systematic literature review on the oral pharmacological treatment and the treatment of refractory overactive bladder gave rise to this second part of the review article Overactive Bladder – 18 years, prepared during the 1st Latin-American Consultation on Overactive Bladder.

https://doi.org/10.1590/S1677-5538.IBJU.2015.0367 2297 downloads

Overactive bladder – 18 years – part I
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Truzzi, Jose Carlos

; Gomes, Cristiano Mendes

; Bezerra, Carlos A.

; Plata, Ivan Mauricio

; Campos, Jose

; Garrido, Gustavo Luis

; Almeida, Fernando G.

; Averbeck, Marcio Augusto

; Fornari, Alexandre

; Salazar, Anibal

; Dell'Oro, Arturo

; Cintra, Caio

; Sacomani, Carlos Alberto Ricetto

; Tapia, Juan Pablo

; Brambila, Eduardo

; Longo, Emilio Miguel

; Rocha, Flavio Trigo

; Coutinho, Francisco

; Favre, Gabriel

; Garcia, José Antonio

; Castaño, Juan

; Reyes, Miguel

; Leyton, Rodrigo Eugenio

; Ferreira, Ruiter Silva

; Duran, Sergio

; López, Vanda

; Reges, Ricardo

International braz j urol

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Abr 2016, Volume 42 Nº 2 Páginas 188 - 198

Resumo: En | Texto: En | PDF: En

ABSTRACT Abstract: Overactive bladder syndrome is one of the lower urinary tract dysfunctions with the highest number of scientific publications over the past two decades. This shows the growing interest in better understanding this syndrome, which gathers symptoms of urinary urgency and increased daytime and nighttime voiding frequency, with or without urinary incontinence and results in a negative impact on the quality of life of approximately one out of six individuals – including both genders and almost all age groups. The possibility of establishing the diagnosis just from clinical data made patients' access to specialized care easier. Physiotherapy resources have been incorporated into the urological daily practice. A number of more selective antimuscarinic drugs with consequent lower adverse event rates were released. Recently, a new class of oral drugs, beta-adrenergic agonists has become part of the armamentarium for Overactive Bladder. Botulinum toxin injections in the bladder and sacral neuromodulation are routine modalities of treatment for refractory cases. During the 1st Latin-American Consultation on Overactive Bladder, a comprehensive review of the literature related to the evolution of the concept, epidemiology, diagnosis, and management was conducted. This text corresponds to the first part of the review Overactive Bladder 18-years.

https://doi.org/10.1590/S1677-5538.IBJU.2015.0365 3261 downloads

A public health risk assessment for yellow fever vaccination: a model exemplified by an outbreak in the state of São Paulo, Brazil
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Ribeiro, Ana Freitas

; Tengan, Ciléa

; Sato, Helena Keico

; Spinola, Roberta

; Mascheretti, Melissa

; França, Ana Cecilia Costa

; Port-Carvalho, Marcio

; Pereira, Mariza

; Souza, Renato Pereira de

; Amaku, Marcos

; Burattini, Marcelo Nascimento

; Coutinho, Francisco Antonio Bezerra

; Lopez, Luis Fernandez

; Massad, Eduardo

Memórias do Instituto Oswaldo Cruz

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Abr 2015, Volume 110 Nº 2 Páginas 230 - 234

Resumo: En | Texto: En | PDF: En

We propose a method to analyse the 2009 outbreak in the region of Botucatu in the state of São Paulo (SP), Brazil, when 28 yellow fever (YF) cases were confirmed, including 11 deaths. At the time of the outbreak, the Secretary of Health of the State of São Paulo vaccinated one million people, causing the death of five individuals, an unprecedented number of YF vaccine-induced fatalities. We apply a mathematical model described previously to optimise the proportion of people who should be vaccinated to minimise the total number of deaths. The model was used to calculate the optimum proportion that should be vaccinated in the remaining, vaccine-free regions of SP, considering the risk of vaccine-induced fatalities and the risk of YF outbreaks in these regions.

https://doi.org/10.1590/0074-02760140345 2714 downloads

Avaliação da atividade antioxidante e citoprotetora dos extratos de Eugenia uniflora Lineau e Psidium sobraleanum Proença & landrum contra metais pesados
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Sobral-Souza, Celestina E

; Leite, Nadghia F

; Cunha, Francisco A. B

; Pinho, Antonio I

; Costa, José G. M

; Coutinho, Henrique D. M

Revista Ciencias de la Salud

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Set 2014, Volume 12 Nº 3 Páginas 401 - 409

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Objetivo: Estudios recientes reportan la utilización de plantas en forma de zumos o té como fuente de agentes antioxidantes naturales que presentan bajo riesgo, pudiendo ser utilizados como complemento del tratamiento de diversas enfermedades. Materiales y métodos: En este contexto, se evaluarán in vitro, los potenciales antioxidantes, de los extractos de Eugenia uniflora y Psidium sobraleanum, además de cuantificar fenoles y flavonoides presentes en los extractos. Resultados: De acuerdo con los resultados obtenidos, se observó una mejor actividad antioxidante con el extracto de Eugenia uniflora, en el test de TBARS con fofolípidos de huevo, los extractos redujeron los niveles basales en el proceso de peroxidación lipídica; y cuando fue inducida con Fe+2, el extracto de Psidium sobraleanum se mostró más eficiente. Conclusiones: Por lo tanto, a través de estos ensayos se pudo comprobar que los extractos de las hojas de las especies Eugenia uniflora y Psidium sobraleanum presentan actividad antioxidante, directamente relacionada con sustancias fenólicas producidas a partir de sus metabolitos secundarios.

Objective: Evaluation of antioxidant activity has been an important issue considering its importance in human health. Recent studies show that the use of plants in the form of juices or teas as sources of natural antioxidants with low risk can be used as an aid to the treatment of various diseases. Material and Methods: Evaluation of the antioxidant potential in vitro, extracts of Eugenia uniflora and Psidium sobraleanum, as well as the quantification of phenols and flavonoids present in the extracts. Results: Findings showed a better antioxidant activity for the extract of Eugenia uniflora. In the TBARS test with egg phospholipids, extracts presented a reduction in the basal levels in the lipid peroxidation process; and when the Fe2 + extract was inducted, Psidium sobraleanum proved to be more efficient.. Conclusions: These tests proved that the extracts of leaves of the species Eugenia uniflora and Psidium sobraleanum present antioxidant activity which is directly related to phenolic substances produced in its secondary metabolism.

Objetivo: Estudos recentes apontam a utilização de plantas na forma de sucos ou chás como fontes de agentes antioxidantes naturais que apresentam baixo risco podendo ser utilizado no auxílio do tratamento de várias doenças. Materiais e métodos: Neste contexto, avaliaram-se os potenciais antioxidantes, in vitro, dos extratos de Eugenia uniflora e Psidium sobraleanum, além de quantificar fenóis e flavonoides presentes nos extratos. Resultados: De acordo com os resultados obtidos, observou-se uma melhor atividade antioxidante para o extrato de Eugenia uniflora, para o teste de TBARS com fosfolipídio de ovo, os extratos reduziram os níveis basais no processo de peroxidação lipídica, e quando induzidos por Fe2+ o extrato de Psidium sobraleanum mostrouse mais eficiente. Conclusões: Portanto, através destes ensaios pode-se verificar que os extratos das folhas das espécies, Eugenia uniflora e Psidium sobraleanum, apresentam uma atividade antioxidante, diretamente relacionada com substâncias fenólicas produzidas a partir do seu metabolismo secundário.

https://doi.org/10.12804/revsalud12.03.2014.08 2116 downloads

Risk of symptomatic dengue for foreign visitors to the 2014 FIFA World Cup in Brazil
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Massad, Eduardo

; Wilder-Smith, Annelies

; Ximenes, Raphael

; Amaku, Marcos

; Lopez, Luis Fernandez

; Coutinho, Francisco Antonio Bezerra

; Coelho, Giovanini Evelim

; Silva Jr, Jarbas Barbosa da

; Struchiner, Claudio José

; Burattini, Marcelo Nascimento

Memórias do Instituto Oswaldo Cruz

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Jun 2014, Volume 109 Nº 3 Páginas 394 - 397

Resumo: En | Texto: En | PDF: En

Brazil will host the FIFA World Cup™, the biggest single-event competition in the world, from June 12-July 13 2014 in 12 cities. This event will draw an estimated 600,000 international visitors. Brazil is endemic for dengue. Hence, attendees of the 2014 event are theoretically at risk for dengue. We calculated the risk of dengue acquisition to non-immune international travellers to Brazil, depending on the football match schedules, considering locations and dates of such matches for June and July 2014. We estimated the average per-capita risk and expected number of dengue cases for each host-city and each game schedule chosen based on reported dengue cases to the Brazilian Ministry of Health for the period between 2010-2013. On the average, the expected number of cases among the 600,000 foreigner tourists during the World Cup is 33, varying from 3-59. Such risk estimates will not only benefit individual travellers for adequate pre-travel preparations, but also provide valuable information for public health professionals and policy makers worldwide. Furthermore, estimates of dengue cases in international travellers during the World Cup can help to anticipate the theoretical risk for exportation of dengue into currently non-infected areas.

https://doi.org/10.1590/0074-0276140133 2334 downloads Citado 3 vezes em SciELO

10.

Atividade antiparasitária in vitro e citotóxica de cariofileno e eugenol contra Trypanossoma cruzi e Leishmania brasiliensis
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Leite, Nadghia F

; Sobral-Souza, Celestina E

; Albuquerque, Rosimeire S

; Brito, Dara I. V

; Lavor, Anne K. L. S

; Alencar, Liscássia B. B

; Tintino, Saulo R

; Ferreira, João V. A

; Figueredo, Fernando G

; Lima, Luciene F

; Cunha, Francisco A. B

; Pinho, Antônio I

; Coutinho, Henrique D. M

Revista Cubana de Plantas Medicinales

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Dez 2013, Volume 18 Nº 4 Páginas 522 - 528

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Introdução: as doenças negligenciadas persistem por conta de falhas da ciência e acometem principalmente países em desenvolvimento, como exemplos podemos citar a doença de Chagas e a leishmaniose. Objetivo: avaliar o potencial antiparasitário in vitro de um terpenóide componente de óleo essencial, o cariofileno e o eugenol, contra as formas epimastigota e promastigota de T. cruzi e L. brasiliensis, respectivamente, bem como verificar sua citotoxicidade em células de mamíferos. Métodos: para os estudos in vitro de T. cruzi, foi usado o clone B5-CL, estavelmente transfectadas com o gene de Escherichia coli ß-galactosidase (lacZ). Os ensaios de inibição de promastigotas foram realizadas utilizando a estirpe de L. braziliensis, cultivadas a 22 ºC em meio de Schneider de Drosophila suplementado com FBS a 20 %. Para os testes de atividade antiepimastigota, antipromastigota foram utilizados placas de 96 poços com culturas que não tinham atingido a fase estacionária. Os ensaios de citotoxicidade utilizado estirpe de fibroblastos NCTC929 cultivadas em Meio Essencial Mínimo (Sigma). A viabilidade dessas linhagens através da utilização de resazurina como um método colorimétrico. Resultados: as substâncias cariofileno e eugenol foram testadas quanto à atividade antiepimastigota, antipromastigota e quanto à citotoxidade. Foi visto um efeito clinicamente relevante do cariofileno contra os parasitas T. cruzi e L. brasiliensi. Conclusões: os resultados mostram que o cariofileno obteve um melhor resultado quando comparado ao eugenol, sendo capaz de inibir o crescimento dos parasitas testados mostrando uma alternativa contra T. cruzi e L. brasiliensi. Em relação à citotoxidade novos testes deverão ser realizados para futuros testes in vivo.

Introduction: neglected diseases continue to exist due to failures in science. They mainly affect developing countries. Two examples of neglected diseases are Chagas' disease and leishmaniasis. Objective: evaluate the potential of an in vitro antiparasitic terpenoid essential oil component, caryophyllene and eugenol, against epimastigotes and promastigotes of Trypanosoma cruzi and Leishmania brasiliensis, respectively, and verify their cytotoxicity in mammal cells. Methods: for in vitro studies of Trypanosoma cruzi, the B5-CL clone was used, stably transfected with the beta-galactosidase gene of Escherichia coli-(lacZ). Inhibition assays were performed on the promastigote strain of Leishmania braziliensis, cultured at 22°C in a Schneider's medium of Drosophila supplemented with 20% FBS. For anti-epimastigote and anti-promastigote activity tests, 96-well plates were used with cultures which had not reached their stationary stage. NCTC929 was used in cytotoxicity tests, a strain of fibroblasts cultured in minimum essential medium (Sigma). The viability of these strains was evaluated using resazurine as colorimetric method. Results: the substances caryophyllene and eugenol were assayed to determine their anti-epimastigote and anti-promastigote activity with respect to cytotoxicity. it was found that caryophyllene has a clinically relevant effect against the parasites Trypanosoma cruzi and Leishmania brasiliensis. Conclusions: results show that caryophyllene was more effective than eugenol, inhibiting the growth of parasites and thus constituting a proven alternative against Trypanosoma cruzi and Leishmania brasiliensis. As to cytotoxicity testing, new studies should be conducted in which more in vivo tests are performed.

Introducción: las enfermedades desatendidas persisten debido a los fracasos de la ciencia y afectan principalmente a los países en desarrollo, como ejemplos se pueden citar la enfermedad de Chagas y la leishmaniasis. Objetivo: evaluar el potencial de un componente in vitro terpenoide antiparasitario aceite esencial, el cariofileno y eugenol contra epimastigotes y promastigotes de Trypanosoma cruzi y Leishmania brasiliensis, respectivamente, así como comprobar su citotoxicidad en células de mamífero. Métodos: para los estudios in vitro de Trypanosoma cruzi, se utilizó el clon B5-CL, transfectadas establemente con el gen de la ß galactosidasa de Escherichia coli-(lacZ). Los ensayos de inhibición se realizaron con la cepa promastigotes de Leishmania braziliensis, se cultivó a 22 °C en medio de Schneider de Drosophila suplementado con FBS 20 %. Para la actividad de las pruebas antiepimastigota y antipromastigota, se utilizaron placas de 96 pocillos con cultivos que no habían alcanzado la fase estacionaria. En los ensayos de citotoxicidad se utilizó NCTC929, cepa de fibroblastos cultivados en medio esencial mínimo (Sigma). La viabilidad de estas cepas se evaluó mediante el uso de la resazurina como un método colorimétrico. Resultados: las sustancias cariofileno y eugenol se ensayaron para determinar la actividad antiepimastigota y antipromastigota, respecto a citotoxicidad. Se observó un efecto clínicamente relevante de cariofileno contra los parásitos Trypanosoma cruzi y Leishmania brasiliensis. Conclusiones: los resultados muestran que con el cariofileno se ha obtenido un mejor resultado en comparación con eugenol, siendo capaz de inhibir el crecimiento de parásitos que presentan una alternativa probada contra Trypanosoma cruzi y Leishmania brasiliensis. En cuanto a las pruebas de citotoxicidad, nuevos estudios deben llevarse a cabo para realizar más pruebas in vivo.

257 downloads

11.

Fatal disseminated strongyloidiasis after kidney transplantation
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Ferreira, Carla Juliana Araújo

; Silva, Débora Albuquerque da

; Almeida, Patrícia Holanda

; Silva, Leila Silveira Vieira da

; Carvalho, Valêncio Pereira

; Coutinho, Antônio Fernando

; Pinheiro, Francisco Gilberto

; Maia, Raimundo Pires

; Silva Junior, Geraldo Bezerra da

; Oliveira, Rodrigo Alves de

Revista da Sociedade Brasileira de Medicina Tropical

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Out 2012, Volume 45 Nº 5 Páginas 652 - 654

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A estrongiloidíase disseminada (ED) é uma doença parasitária rara de difícil diagnóstico que acomete indivíduos imunocomprometidos. Relatamos um caso de um paciente transplantado renal que desenvolveu ED apesar do uso de profilaxia com albendazol. São discutidas estratégias profiláticas e de diagnóstico da estrongiloidíase disseminada.

Disseminated strongyloidiasis (DS) is a rare and severe parasitic disease that is difficult to recognize and affects immunocompromised individuals. We report the case of a kidney transplant recipient who presented with DS despite prophylaxis with albendazole. We have discussed the need for better prophylactic strategies and for a higher degree of suspicion in order to diagnose DS.

4161 downloads

12.

Vectorial capacity, basic reproduction number, force of infection and all that: formal notation to complete and adjust their classical concepts and equations
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Massad, Eduardo

; Coutinho, Francisco Antonio Bezerra

Memórias do Instituto Oswaldo Cruz

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Jun 2012, Volume 107 Nº 4 Páginas 564 - 567

Resumo: En | Texto: En | PDF: En

A dimensional analysis of the classical equations related to the dynamics of vector-borne infections is presented. It is provided a formal notation to complete the expressions for the Ross' Threshold Theorem, the Macdonald's basic reproduction "rate" and sporozoite "rate", Garret-Jones' vectorial capacity and Dietz-Molineaux-Thomas' force of infection. The analysis was intended to provide a formal notation that complete the classical equations proposed by these authors.

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13.

II Diretriz de Avaliação Perioperatória da Sociedade Brasileira de Cardiologia
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Feitosa, Alina Coutinho Rodrigues

; Marques, André Coelho

; Caramelli, Bruno

; Ayub, Beatriz

; Polanczyk, Carisi A.

; Jardim, Carlos

; Vieira, Carolina L. Zilli

; Pinho, Claudio

; Calderaro, Daniela

; Gualandro, Danielle Menosi

; Iezzi, Denise

; Ikeoka, Dimas T.

; Schreen, Dirk

; D'Amico, Elbio Antonio

; Pfeferman, Elcio

; Lima, Emerson Quintino de

; Burdmann, Emmanuel de A.

; Pachon, Enrique

; Machado, Fabio Santana

; Galas, Filomena Regina Barbosa Gomes

; Paula, Flávio Jota de

; Carvalho, Francine Corrêa de

; Feitosa-Filho, Gilson Soares

; Prado, Gustavo Faibischew

; Lopes, Heno F.

; Lima, José Jaime Galvão de

; Marchini, Julio Flavio Meirelles

; Fornari, Luciana S.

; Drager, Luciano F.

; Vacanti, Luciano Janussi

; Hajjar, Ludhmila Abrahão

; Rohde, Luis Eduardo P.

; Gowdak, Luís Henrique

; Cardoso, Luiz Francisco

; Vieira, Marcelo Luiz Campos

; Monachini, Maristela C.

; Macatrão, Milena

; Yu, Pai Ching

; Villaça, Paula Ribeiro

; Farsky, Pedro Silvio

; Lopes, Renato Delascio

; Bagnatori, Renato Scotti

; Heinisch, Roberto Henrique

; Gualandro, Sandra F. Menosi

; Accorsi, Tarso Augusto Duenhas

; Ávila, Walkiria Samuel

; Mathias Jr., Wilson

Arquivos Brasileiros de Cardiologia

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2011, Volume 96 Nº 3 Páginas 1 - 68

Resumo: Pt | Texto: Pt | PDF: Pt

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14.

The risk of acquiring the new influenza A(H1N1) for Brazilian travelers to Chile, Argentina and the USA
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Massad, Eduardo

; Burattini, Marcelo Nascimento

; Coutinho, Francisco Antonio

; Struchiner, Cláudio José

Memórias do Instituto Oswaldo Cruz

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Mar 2010, Volume 105 Nº 2 Páginas 179 - 183

Resumo: En | Texto: En | PDF: En

We estimate the risk of acquiring the new influenza A(H1N1) for Brazilian travelers to Chile, Argentina and the USA. This is done by a mathematical model that quantifies the intensity of transmission of the new virus in those countries and the probability that one individual has of acquiring the influenza depending on the date of arrival and time spent in the area. The maximum estimated risk reached 7.5 cases per 10,000 visitors to Chile, 17 cases per 10,000 travelers to Argentina and 23 cases per 10,000 travelers to the USA. The estimated number of imported cases until 27 July is 57 ± 9 from Chile, 136 ± 27 from the USA and 301 ± 21 from Argentina, which are in accord with the official figures. Estimating the number of imported cases was particularly important for the moment of the disease introduction into this country, but it will certainly be important again as a tool to calculate the number of future imported cases from northern countries in our next inter-epidemic season, were imported cases can constitute again the majority of the new influenza burden to the Brazilian health services.

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15.

Avaliação e mensuração da sutura palatina mediana por meio da radiografia oclusal total digitalizada em pacientes submetidos à expansão rápida maxilar
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David, Sandra Maria Nobre

; Castilho, Julio Cezar de Melo

; Ortolani, Cristina Lucia Feijó

; David, Antonio Francisco

; Manhães Junior, Luiz Roberto Coutinho

; Matsui, Roberto Hiroshi

Revista Dental Press de Ortodontia e Ortopedia Facial

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Out 2009, Volume 14 Nº 5 Páginas 62 - 68

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

OBJETIVOS: avaliar e mensurar a sutura palatina mediana por meio de radiografias oclusais totais de maxila digitalizadas, antes e depois da sua disjunção. MÉTODOS: a amostra constou de 17 pacientes, com idades entre 7 e 22 anos. Radiografias oclusais totais da maxila foram executadas antes e depois da abertura da sutura palatina mediana, e digitalizadas em scanner HP Scanjet 6110 C com adaptador de transparências HPC 6261 6100 C, utilizando-se o programa Deskscan II. Para a avaliação e medição, foi utilizado o programa Radioimp® (Radiomemory, MG/Brasil). Na análise estatística, foram utilizados a média, o desvio-padrão, o coeficiente de variação e os testes "t" e ANOVA. CONCLUSÕES: após os resultados, foi possível concluir que (1) na região dos incisivos, houve uma abertura palatina mediana estatisticamente significativa; (2) houve abertura de diastema entre os incisivos centrais superiores em torno de 69,37% dos casos; (3) houve uma maior abertura da sutura palatina mediana na região a 10mm a partir da crista para posterior, em comparação com a região a 3mm para posterior do parafuso expansor; (4) na região a 3mm para posterior do parafuso expansor houve uma abertura de 35,97%, e na região a 10mm para posterior da crista uma abertura de 69,37%.

AIM: to evaluate and to measure the midpalatal suture through digitalized occlusal radiographies before and after its disjunction. METHODS: The sample was comprised by 17 patients, with ages from 7 to 22 years. Occlusal radiographies of these patients were obtained before and after the suture's opening. The occlusal radiographies were digitalized in a HP Scanjet 6100 C scanner with the HPC 6261 6100 C transparencies adaptor and the Deskscan II software. The statistical analysis used average, standard deviation, variation coefficient, "t" test and ANOVA. CONCLUSIONS: After the results, it was possible to conclude that: (1) statistically, there was a significant midpalatal opening in the incisors area; (2) there was an opening in the diastema between upper central incisors in about 69.37% of the cases; (3) there was a bigger midpalatal suture opening in the 10mm area from the crest to posterior than in the 3mm area to posterior from the screw; (4) in the 3mm area to posterior from the screw there was an opening of 35.97% and in the 10mm area to posterior of the crest there was an opening of 69.37%.

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