Abstract Hibiscus acetosella was shown to exert beneficial effects in humans and animal models however, the effects of this plant on DNA are unknown. The aim of this study was to determine the antigenotoxic and antimutagenic effects of H. acetosella extracts on alkylating agent methyl methanesulfonate (MMS) in vivo in mice. Initially, we performed analysis of phenolic compounds in extracts of H. acetosella by high-performance liquid chromatography (HPLC). Next, mice were divided into 8 groups and treated with distilled water or plant extract (0.1 ml/10 g) by gavage for 15 days, followed by intraperitoneal (ip) administration of saline solution or MMS (40 mg/Kg b.w) on day 16. Caffeic acid, following by gallic acid, gallocatechin, coumaric acid, and 3,4-dihydroxybenzoic acid were found to be present in extracts of H. acetosella leaves. In peripheral blood analysis of groups receiving pretreatment with H. acetosella at doses of 50 or 100 mg/kg plus MMS decreased DNA damage as evidenced by comet assay and Micronucleus assays relative to MMS alone. These results suggested that H. acetosella extracts exerted protective effects dose dependent against genotoxicity and mutagenicity induced by alkylating agents.

Resumo Estudo transversal, baseado em dados do sistema de monitoramento por inquérito telefônico – VIGITEL, com o objetivo de estimar a prevalência e os fatores associados ao consumo recomendado de frutas, legumes e verduras (FLV) em 6696 indivíduos com idade ≥ 18 anos, de ambos os sexos, residentes na Região Centro-Oeste do Brasil, em 2012. O consumo recomendado foi a variável dependente e variáveis sociodemográficas, comportamentais e relacionadas à saúde foram as independentes. A prevalência do consumo recomendado de FLV foi de 26,3%, sendo maior entre as mulheres (RPaj = 1,44; IC95% = 1,29–1,62). A regressão de Poisson entre o desfecho e as variáveis independentes mostrou maior prevalência do consumo recomendado entre as mulheres residentes no Distrito Federal, casadas e que consideravam seu estado de saúde como bom/muito bom. Em ambos os sexos, observou-se associação direta do desfecho com a escolaridade, idade e prática de atividade física e associação inversa com o consumo de alimentos não saudáveis. Devido à baixa prevalência do consumo recomendado de FLV na população da Região Centro-Oeste do Brasil no ano de 2012, propõe-se que as estratégias de intervenção para melhorar o consumo desses alimentos sejam feitas de forma globalizada.

Abstract This is a cross-sectional study based on data from the VIGITEL telephone health monitoring survey, aiming to describe the prevalence of adequate fruit, greens and vegetable intake and to identify associated factors. This population-based study included 6696 individuals aged ≥ 18 years, living in the Midwest of Brazil, in 2012. The adequate consumption of fruit, greens and vegetables (FGV) was the dependent variable and sociodemographic, behavioral and health factors were the independent variables. The prevalence of adequate FGV consumption was 26.3%, being higher among women (RPaj = 1.44; CI95% = 1.29-1.62). The Poisson regression showed that the adequate consumption of FGV was higher among women resident in the Federal District, married and who considered their own health as good/very good. In both genders there was a direct association with education, age and physical activity and inversely associated with the consumption of unhealthy foods. Due to the low prevalence of adequate fruit, greens and vegetable intake in the population of Brazil’s Midwest region in 2012, it is proposed that the intervention strategies to increase the consumption of these foods should be encouraged in a global manner.

Resumo Estudo transversal, baseado em dados do sistema de monitoramento por inquérito telefônico – VIGITEL, com o objetivo de estimar a prevalência e os fatores associados ao consumo recomendado de frutas, legumes e verduras (FLV) em 6696 indivíduos com idade ≥ 18 anos, de ambos os sexos, residentes na Região Centro-Oeste do Brasil, em 2012. O consumo recomendado foi a variável dependente e variáveis sociodemográficas, comportamentais e relacionadas à saúde foram as independentes. A prevalência do consumo recomendado de FLV foi de 26,3%, sendo maior entre as mulheres (RPaj = 1,44; IC95% = 1,29–1,62). A regressão de Poisson entre o desfecho e as variáveis independentes mostrou maior prevalência do consumo recomendado entre as mulheres residentes no Distrito Federal, casadas e que consideravam seu estado de saúde como bom/muito bom. Em ambos os sexos, observou-se associação direta do desfecho com a escolaridade, idade e prática de atividade física e associação inversa com o consumo de alimentos não saudáveis. Devido à baixa prevalência do consumo recomendado de FLV na população da Região Centro-Oeste do Brasil no ano de 2012, propõe-se que as estratégias de intervenção para melhorar o consumo desses alimentos sejam feitas de forma globalizada.

Abstract This is a cross-sectional study based on data from the VIGITEL telephone health monitoring survey, aiming to describe the prevalence of adequate fruit, greens and vegetable intake and to identify associated factors. This population-based study included 6696 individuals aged ≥ 18 years, living in the Midwest of Brazil, in 2012. The adequate consumption of fruit, greens and vegetables (FGV) was the dependent variable and sociodemographic, behavioral and health factors were the independent variables. The prevalence of adequate FGV consumption was 26.3%, being higher among women (RPaj = 1.44; CI95% = 1.29-1.62). The Poisson regression showed that the adequate consumption of FGV was higher among women resident in the Federal District, married and who considered their own health as good/very good. In both genders there was a direct association with education, age and physical activity and inversely associated with the consumption of unhealthy foods. Due to the low prevalence of adequate fruit, greens and vegetable intake in the population of Brazil’s Midwest region in 2012, it is proposed that the intervention strategies to increase the consumption of these foods should be encouraged in a global manner.