Pesquisa | SciELO

Abstract Background Major advances have been seen in techniques and devices for performing percutaneous coronary interventions (PCIs) for chronic total occlusions (CTOs), but there are limited real-world practice data from developing countries. Objectives To report clinical and angiographic characteristics, procedural aspects, and clinical outcomes of CTO PCI performed at dedicated centers in Brazil. Methods Included patients underwent CTO PCI at centers participating in the LATAM CTO Registry, a Latin American multicenter registry dedicated to prospective collection of these data. Inclusion criteria were procedures performed in Brazil, age 18 years or over, and presence of CTO with PCI attempt. CTO was defined as a 100% lesion in an epicardial coronary artery, known or estimated to have lasted at least 3 months. Results Data on 1196 CTO PCIs were included. Procedures were performed primarily for angina control (85%) and/or treatment of moderate/severe ischemia (24%). Technical success rate was 84%, being achieved with antegrade wire approaches in 81% of procedures, antegrade dissection and re-entry in 9%, and retrograde approaches in 10%. In-hospital adverse cardiovascular events occurred in 2.3% of cases, with a mortality rate of 0.75%. Conclusions CTOs can be treated effectively in Brazil by using PCI, with low complication rates. The scientific and technological development observed in this area in the past decade is reflected in the clinical practice of dedicated Brazilian centers.

Resumo Fundamento Tem sido observado um grande avanço nas técnicas e nos dispositivos para a realização de intervenções coronárias percutâneas (ICP) em oclusões totais coronarianas crônicas (OTC), mas existem poucos dados da prática do mundo real em países em desenvolvimento. Objetivos Relatar as características clínicas e angiográficas, os aspectos dos procedimentos e os resultados clínicos da ICP de OTC em centros dedicados a esse procedimento no Brasil. Métodos Os pacientes incluídos foram submetidos à ICP de OTC em centros participantes do LATAM CTO Registry, um registro multicêntrico latino-americano dedicado à coleta prospectiva desses dados. Os critérios de inclusão foram procedimentos realizados no Brasil, idade acima de 18 anos e presença de OTC com tentativa de ICP. A definição de OTC foi lesão de 100% em uma artéria coronária epicárdica, conhecida ou estimada como tendo pelo menos 3 meses de evolução. Resultados Foram incluídos dados de 1.196 ICPs de OTC. Os procedimentos foram realizados principalmente para controle da angina (85%) e/ou tratamento de uma grande área isquêmica (24%). A taxa de sucesso técnico foi de 84% e foi alcançada com técnicas de fios anterógrados em 81%, dissecção/reentrada anterógrada em 9% e retrógrada em 10% dos procedimentos. Os eventos cardiovasculares adversos intra-hospitalares ocorreram em 2,3% dos casos, sendo a mortalidade de 0,75%. Conclusões As OTC podem ser tratadas no Brasil por intervenção coronária percutânea de forma efetiva e com baixas taxas de complicações. O desenvolvimento científico e tecnológico observado nessa área na última década reflete-se na prática clínica de centros brasileiros dedicados a essa técnica.

https://doi.org/10.36660/abc.20210462

Oral mucositis and microbial status in acute lymphoblastic leukemia subjects undergoing high-dose chemotherapy
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Duarte, Ana Cláudia Nunes

; Barbosa, Anderson Nogueira

; Saito, Cristiane Pereira Borges

; Paula, Erich Vinicius de

; Saito, Daniel

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e237697

Resumo: En | Texto: En | PDF: En

Aim To assess oral microbial status in patients with acute lymphoblastic leukemia (ALL) undergoing high-dose chemotherapy and to unravel possible associations between nosocomial pathogens and the establishment of chemotherapy-induced oral mucositis (CIOM). Methods Oral mucosa, saliva, and peripheral blood samples were collected from 46 ALL subjects one day prior to chemotherapy (D0) and 2 weeks after treatment initiation (D14). Clinical intraoral inspection was performed by a single practitioner, with mucositis classification performed according to the WHO oral toxicity scale. Blood components were quantified by automatic flow cytometry, while oral Staphylococcus aureus and Pseudomonas aeruginosa were detected by Polymerase Chain Reaction with species-specific primers. Associations among bacteria and clinical findings were determined by Fisher’s Exact test, longitudinal bacterial changes by paired Macnemar, and correlations among blood parameters and mucositis status or bacteria via Mann-Whitney. Results S. aureus displayed higher detection rates at D14 (p < 0.05) and was positively associated with mucositis, adoption of a non-solid diet (all p < 0.001), nausea and fever (all p < 0.05). Conversely, P. aeruginosa did not correlate to CIOM clinical parameters. At the systemic standpoint, lower hemoglobin levels associated with CIOM and fever events (all p < 0.01). Conclusion The study evidences S. aureus as a potential pathogen in ALL-CIOM, reaffirming microbial control as an important preventive measure during high-dose immunosuppressive therapy. The weight of non-white-blood-cell parameters should be validated as novel CIOM biomarkers in prospective research.

https://doi.org/10.20396/bjos.v22i00.8667697

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Supl. 3 elocation e23022

Resumo: En | Texto: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

CFRP repair effectiveness on compressed steel tubular members with circular cutout
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Martinez, Jorge Luis

; Cyrino, Julio Cesar Ramalho

; Vaz, Murilo Augusto

; Hernández, Irving David

; Torres, Victor Daniel

; Perrut, Valber Azevedo

; Paula, Gustavo Gomes de

Latin American Journal of Solids and Structures

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2023, Volume 20 Nº 2 elocation e477

Resumo: En | Texto: En | PDF: En

Abstract Welding procedures for repairing corroded tubular structures are commonly used; however, composite material repairs are becoming popular since they do not use heat sources that might cause accidents. This paper provides a detailed description of the CFRP patch repair application in steel tubular members with a circular perforation originated from a prolonged corrosion process. The results of experimental tests on mid-scale unrepaired damaged and repaired steel tubes are reported. The predictions of the maximum loads recovered from a proposed numerical model lie close to the experimental observed values, justifying its usage for analysis of repaired tubular structures with circular cutouts when subjected to axial compression. Compared to unrepaired perforated tubes, the experimental results demonstrate a substantial strength recovery for repaired tubes. The value of this research for the oil and gas industry is that it demonstrates the feasibility of this kind of repair, which means reduced risk to the production unit and a shorter repair period. used however accidents process midscale mid scale reported values compression period

https://doi.org/10.1590/1679-78257357

Encuesta para Cuidadores de Personas del Espectro Autista en Chile. Acceso a Servicios de Salud y Educación, Satisfacción, Calidad de Vida y Estigma
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García, Ricardo

; Irarrázaval, Matías

; López, Isabel

; Riesle, Sofía

; Cabezas, Marcia

; Moyano, Andrea

; Garrido, Gabriela

; Valdez, Daniel

; S de Paula, Cristiane

; Rosoli, Analía

; Cukier, Sebastián

; Montiel-Nava, Cecilia

; Rattazzi, Alexia

Andes pediatrica

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Jun 2022, Volume 93 Nº 3 Páginas 351 - 360

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: People on the Autism Spectrum (AS) face multiple health, education, social, and economic pro blems. There is limited available information in Chile. Objective: To describe the access and satisfac tion with health and education services, family and economic impact, stigma, and quality of life of people with AS and their families in Chile. Subjects and Method: Parents/caregivers of AS persons completed the Caregiver Needs Survey, developed by Autism Speaks, which includes demographic information, characteristics of AS persons (previously published), use of health and education servi ces, parents/caregivers’ perceptions of satisfaction, impact, stigma, and quality of life. Results: 291 caregivers (86% mothers) of 291 AS persons participated, 89% were male, aged 1-40 years (X:10.4 SD:6.1). Limited and unspecific access to health services is reported. 77% are regularly attending a standard or special school system. Families pay for over 60% of therapies/medical care and over 40% of specific educational support, and 25% report difficulties in accessing services. The family income is affected by resignation (35%) or reduced working hours (46%). Stigma is associated with possi ble discrimination and feelings of helplessness. The main priorities mentioned for a better quality of life are support for inclusive schooling, better adjustment at home, and improved socialization. Conclusions: This survey provides relevant information about the needs, barriers, and challenges of AS people in Chile and highlights the difficulties in accessing health services and the severe impact on family income. Feelings of stigma, discrimination, and helplessness are reported. Collaborative strategies are needed to improve the quality and access to services and to reduce the economic and mental health burden on the family.

Resumen: Introducción: Las personas del Espectro Autista (EA) enfrentan múltiples necesidades de salud, educación, proble mas sociales y económicos. La información disponible en Chile es insuficiente. Objetivo: Conocer el acceso y satisfacción con servicios de salud y educación, el impacto familiar y económico, estigma y calidad de vida de personas EA y sus familias en Chile. Sujetos y Método: Padres/cuidadores de perso nas EA respondieron la Encuesta de Necesidades de Cuidadores, desarrollada por Autism Speaks, que comprende: información demográfica, características de las personas EA (publicado previamente), utilización de servicios de salud y educación, percepciones de padres/cuidadores en satisfacción, im pacto, estigma y calidad de vida (que presenta esta publicación). Resultados: Participaron 291 cuida dores (86% madres), de 291 personas EA, 89% varones, de 1-40 años (X:10,4 DE:6,1). Se reporta un acceso insuficiente y poco específico a servicios de salud. Un 77% asiste regularmente a algún sistema escolar regular o especial. Las familias financian sobre 60% de terapias/atención médica y sobre 40% de apoyos educacionales específicos; un 25% refiere dificultades de acceso a servicios. La economía familiar se afecta por renuncia (35%) o reducción de jornadas laborales de los cuidadores (46%). El estigma se asocia a posible discriminación y sentimientos de impotencia. Las principales prioridades mencionadas para una mejor calidad de vida son apoyos para escolaridad inclusiva, mejor adaptación en el hogar y mejorar la socialización. Conclusiones: Esta encuesta aporta información relevante acerca de las necesidades, barreras y desafíos de las personas EA en Chile. Destacan las dificultades de acceso a servicios de salud y el severo impacto sobre el ingreso económico familiar. Existe estigma, discriminación e impotencia. Se requiere elaborar estrategias colaborativas para mejorar la calidad y acceso a servicios y reducir la carga económica y de salud mental familiar.

https://doi.org/10.32641/andespediatr.v93i3.3994 55 downloads

Accumulation of nutrients during the formation of star fruit cultivars under different irrigation regimes
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ROZANE, DANILO EDUARDO

; PRADO, RENATO DE MELLO

; PAULA, BETANIA VAHL DE

; SANTOS, EDUARDO MACIEL HAITZMANN DOS

; NATALE, WILLIAM

; AMORIM, DANIEL ANGELUCCI DE

; HERNANDES, AMANDA

Revista Colombiana de Ciencias Hortícolas

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Mai 2022, Volume 16 Nº 2 elocation e13832

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La acumulación de nutrientes durante la formación de árboles de carambola (Averrhoa carambola) puede ser afectado por el régimen de agua y por el cultivar, sin embargo, esto aún no es conocida para esta especie. El propósito de este estudio fue evaluar la acumulación de nutrientes de dos cultivares de carambola en fase de formación, bajo dos regímenes de irrigación. El experimento fue realizado en campo, mediante diseño completamente al azar, con parcelas divididas, siendo estas parcelas dos niveles de irrigación (con y sin irrigación) y, como subparcelas, dos cultivares de carambola (B-10 y Golden Star) y siete épocas de recogida de plantas, entre 0 a 720 días después del transplante (DAT), con seis réplicas. La acumulación de nutrientes fue evaluada en el tallo y las hojas, y fue posible observar que la toma de nutrientes y la tasa promedio de acumulación siguió la acumulación de masa seca de los árboles de carambola en formación. La acumulación de nutrientes por la parte aérea a los 720 DAT fue diferente, siendo que para la 'Golden Star' en el régimen seco y para la 'B-10' en ambos regímenes de irrigación no hubo diferencia, siguiendo la secuencia Ca > K > N > Mg > S > P > Mn > Fe > Zn > B > Cu, y para el cultivar Golden Star en el régimen irrigado, la secuencia de acumulación fue Ca > K > N > Mg > Mn > P > S > Fe > Zn > B > Cu. La más alta acumulación ocurrió en el régimen irrigado, independientemente del cultivar. El cultivar Golden Star acumuló, en promedio, cantidades mayores de N, P, K, Mg, S, Fe y Mn.

ABSTRACT Nutrient accumulation during the formation of star fruit (Averrhoa carambola) trees can be affected by the water regime and by the cultivar, but the details are not yet known for this species. The aim of this study was to evaluate the nutrient uptake of two star fruit cultivars in the formation phase under two irrigation regimes. The experiment was developed with a completely randomized design, with subdivided plots, with two irrigation levels (with and without irrigation) as plots, and two star fruit cultivars as subplots ('B-10' and 'Golden Star') and seven collection times from 0 to 720 days after transplanting (DAT) into the field as sub-subplots with six replicates. Nutrient uptake was evaluated in stem and leaves, and it was possible to observe that nutrient uptake and the average accumulation rate followed the dry matter mass accumulation of star fruit trees in formation. Nutrient uptake by shoots at 720 DAT differed for the Golden Star cultivar in the rainfed regime and for the B-10 cultivar in both irrigation regimes. There was no difference and followed the sequence Ca > K > N > Mg > S > P > Mn > Fe > Zn > B > Cu, and for Golden Star cultivar in the irrigated regime, the accumulation sequence was Ca> K> N> Mg> Mn> P> S> Fe> Zn > B> Cu. The highest accumulation occurred in the irrigated regime regardless of cultivar. Golden Star cultivar accumulated, on average, larger amounts of N, P, K, Mg, S, Fe and Mn.

https://doi.org/10.17584/rcch.2022v16i2.13832

Seroprevalence and hematological abnormalities associated with Ehrlichia canis in dogs referred to a veterinary teaching hospital in central-western Brazil
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Paula, Warley Vieira de Freitas

; Taques, Ísis Indaiara Gonçalves Granjeiro

; Miranda, Vanessa Carvalho

; Barreto, Ana Laura Gonçalves

; Paula, Luiza Gabriella Ferreira de

; Martins, Danieli Brolo

; Damasceno, Adilson Donizeti

; Muñoz-Leal, Sebastián

; Sevá, Anaiá da Paixão

; Dantas-Torres, Filipe

; Aguiar, Daniel Moura de

; Krawczak, Felipe da Silva

Ciência Rural

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2022, Volume 52 Nº 2 elocation e20201131

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Carrapatos são importantes parasitos de cães nos trópicos, onde patógenos transmitidos por carrapatos são altamente prevalentes, especialmente em áreas onde as medidas de controle de carrapatos são frequentemente negligenciadas. O estudo investigou a soroprevalência e as anormalidades hematológicas associadas à Ehrlichia canis em cães encaminhados para um hospital veterinário-escola no Centro-oeste do Brasil. Dos 264 cães testados para anticorpos anti-Ehrlichia canis por meio da reação de imunofluorescência indireta (RIFI), 59.1% (156/264) foram positivos. A soropositividade foi associada significativamente à anemia e trombocitopenia, isoladamente ou em combinação, e à leucopenia. Por outro lado, não houve diferenças quanto à soroprevalência segundo sexo, raça e idade. Este estudo demonstrou que cães encaminhados a um hospital veterinário-escola na região Centro-oeste do Brasil são altamente expostos à E. canis, e que cães soropositivos têm maior probabilidade de apresentar alterações hematológicas, principalmente anemia, trombocitopenia e leucopenia. Para o nosso conhecimento, este é o primeiro estudo sobre a detecção de anticorpos anti-E. canis por meio da RIFI em cães do estado de Goiás. Essas descobertas destacam a necessidade de aumentar a conscientização entre os proprietários de cães em relação às medidas de controle do carrapato no Centro-oeste do Brasil, em última análise, para reduzir o risco de exposição ao E. canis e outros patógenos transmitidos por carrapatos.

ABSTRACT: Ticks are significant parasites of dogs in the tropics, where tick-borne pathogens are highly prevalent, especially in areas where tick control measures are frequently neglected. This study investigated the seroprevalence and hematological abnormalities associated with Ehrlichia canis in dogs referred to a veterinary teaching hospital in Central-western Brazil. Out of 264 dogs tested for anti-Ehrlichia canis antibodies by an indirect immunofluorescence assay (IFA), 59.1% (156/264) were positive. Seropositivity was significantly associated to anemia and thrombocytopenia, alone or in combination, and to leukopenia. Conversely, there were no differences in terms of seroprevalence according to sex, breed and age. This study demonstrated that dogs referred to a veterinary teaching hospital in Central-western Brazil are highly exposed to E. canis and that seropositive dogs are more likely to present hematological abnormalities, particularly anemia, thrombocytopenia and leukopenia. To our knowledge, this is the first study on detection of anti-E. canis antibodies by means of IFA among dogs in the state of Goiás. These findings highlighted the need for increasing awareness among dog owners regarding tick control measures in Central-western Brazil, ultimately to reduce the risk of exposure to E. canis and other tick-borne pathogens.

https://doi.org/10.1590/0103-8478cr20201131 160 downloads

Potassium uptake kinetics in native forage grass species from Pampa Biome
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Fernandes, Gracieli

; Marques, Anderson César Ramos

; Ribeiro, Bruna San Martin Rolim

; Cardoso, Paula de Souza

; Tagliapietra, Eduardo Lago

; Friedrich, Eduardo Daniel

; Weber, Patric Scolari

; Krug, Amanda Veridiana

; Kulmann, Matheus Severo de Souza

; Paula, Betania Vahl de

; Nicoloso, Fernando Teixeira

; Brunetto, Gustavo

Ciência Rural

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2022, Volume 52 Nº 11 elocation e20200708

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O estudo quantificou os parâmetros cinéticos de captação de K nas gramíneas Paspalum notatum, Paspalum urvillei e Axonopus affinis associados com o crescimento. Dez mililitros (10 ml) de solução nutritiva foram coletados em vasos de dois litros - com cinco repetições em 24 horas - para determinação das concentrações de K nas amostras. A matéria seca da parte aérea e raízes; comprimento, volume, diâmetro e área superficial radicular, bem como parâmetros cinéticos associados à absorção de nutrientes (Vmax, Km, Cmin e I) foram avaliados. A espécie P. notatum apresentou a maior produção de raiz, parte aérea e MS total, bem como o maior volume de raiz. P. urvillei apresentou o maior teor de K, que pode ser associado a raízes mais finas e resultando em maior área superficial. A. affinis registrou o maior valor de Vmax, o que levou a uma maior eficiência de absorção de K.

ABSTRACT: This study quantified K uptake kinetic parameters in grass species Paspalum notatum, Paspalum urvillei and Axonopus affinis to associate them with growth. Ten milliliters (10 ml) of nutrient solution were collected in two-liter pots - with five repetitions in 24 hours - in order to determine K concentrations in the samples. Shoot and root dry matter, root length, volume, diameter and surface area, as well as kinetic parameters associated with nutrient uptake (Vmax, Km, Cmin and I) were determined. Species P. notatum was the one presenting the highest root, shoot and total dry matter production, as well as the highest root volume. P. urvillei recorded the highest K content, which may be associated with thinner roots and greater root surface area. A. affinis recorded the highest Vmax value, which led to greater K uptake efficiency.

https://doi.org/10.1590/0103-8478cr2020

Effect of thermal treatment on the physical properties of GG100 clone Eucalyptus wood
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Batista, Felipe Gomes

; Medeiro, Dayane Targino de

; Mascarenhas, Adriano Reis Prazeres

; Mendes, Lourival Marin

; Silva, Danilo Wisky

; Farias, Daniel Tavares de

; Pimenta, Alexandre Santos

; Rodolfo Junior, Francisco

; Paula, Edgley Alves de Oliveira

; Melo, Rafael Rodolfo de

Matéria (Rio de Janeiro)

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2022, Volume 27 Nº 3 elocation e20220106

Resumo: En | Texto: En | PDF: En

ABSTRACT Thermal treatment can modify undesirable characteristics of some woods, dimensional instability, and excessive water adsorption. The present research work aimed to assess the effect of thermal treatment on the physical properties of clone GG100 Eucalyptus wood. Wood samples were obtained from 9 year-old trees. Samples were subjected to three types of thermal treatment (T1, T2, and T3). In T1, the wood was kept in a laboratory kiln at 100 °C for 180 min. In T2, hydrothermal treatment was performed in an autoclave at 120 °C for 120 min. In T3, the combined autoclave and laboratory kiln treatments were employed. The properties evaluated were apparent density (ρa); mass loss (ML); longitudinal (βl), radial (βr), tangential (βt), and volumetric shrinkage (βv); anisotropic factor; and equilibrium moisture content. The treatments caused a decrease of ρa and increase of ML. The Equilibrium Moisture Content (EMC) was lowest for T3, and had a negative correlation with ML, βt, and ∆v. The Pearson correlation analysis indicated the results of the thermal treatments were similar, but T1 presented the lowest variation of the physical properties compared to the other treatments, giving it the best predictability for practical uses.

https://doi.org/10.1590/1517-7076-rmat-2022-0106

10.

Contrasting functional responses of non-native invasive species along a tropical elevation gradient
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Gillerot, Loïc

; Negreiros, Daniel

; Barbosa, Newton P. U.

; Silveira, Fernando A.O.

; Paula, Luiza F. A. de

Acta Botanica Brasilica

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Dez 2021, Volume 35 Nº 4 Páginas 683 - 688

Resumo: En | Texto: En | PDF: En

ABSTRACT One hypothesized invasion strategy (“try-harder”) predicts that invaders exhibit functional traits that are better adjusted to the environment than native species. Alternatively, the “join-the-locals” hypothesis predicts trait convergence between invasive and native species due to environmental filtering with increasing resource limitation. We hypothesized that invasions strategies shift from “try-harder” to “join-the-locals” with increasing elevation. We used an elevational gradient to detect possible trait convergences between alien invaders and native plant species in Asteraceae, Fabaceae and Poaceae. We found a significant trait convergence with elevation only in Asteraceae, suggesting a species-specific pattern, but also an important phenotypic variability of the alien invader. This supports the idea that the more resource-limited the environment, the more it filters out traits substantially diverging from the locally-adapted native community, thereby entailing a shift from “try-harder” to “join-the-locals” strategies. The invasive grass was also more acquisitive but did not exhibit any relation to the native community, supporting the “try-harder” hypothesis. The size of the invasive Fabaceae species decreased with elevation, mirroring the native Fabaceae species, but not the overall native community. Including more replicates and a thorough quantification of environmental conditions, offers a promising avenue for improving the understanding the seemingly idiosyncrasies of invasion pathways.

https://doi.org/10.1590/0102-33062021abb0017

11.

Migraine and sleep deprivation: integrative review
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Thomaz, Tania Gouvêa

; Paula, Ana Ester Amorim de

; Alves, Daniel de Moraes

; Alves, Luana Lemos

; Fonseca, Pedro Guilherme Mol da

BrJP

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Dez 2021, Volume 4 Nº 4 Páginas 379 - 387

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO JUSTIFICATIVA E OBJETIVOS: Migrânea é um tipo de cefaleia primária e sua fisiopatologia permanece incompleta. A relação entre o sono e a migrânea é facilmente identificada pelos pacientes migranosos. O objetivo deste estudo foi investigar a relação entre privação de sono e a migrânea. CONTEÚDO: Foi feita uma busca por artigos utilizando os termos: “migraine” e “sleep deprivation” nas bases de dados Pubmed, Biblioteca Virtual da Saúde (LILACS e IBECS) e Scielo. A primeira análise foi feita com base no título e no resumo. Nos casos em que o título e o resumo não foram esclarecedores, o artigo foi acessado na íntegra. Após a aplicação dos critérios de exclusão, restaram 49 artigos. Estes artigos foram analisados e organizados em duas tabelas: uma destinada aos artigos que tratavam o sono como um gatilho e a outra com artigos que exploravam a relação fisiopatológica entre sono e migrânea. CONCLUSÃO: É possível que a privação do sono provoque ou agrave as crises de migrânea devido a sua capacidade de causar estresse oxidativo no cérebro, que ativa receptores TRPA1 localizados nos neurônios trigeminais de 1a ordem. A ativação destes receptores inicia o processo de sensibilização do sistema trigeminal que culmina com a liberação antidrômica de peptídeo relacionado ao gene da calcitonina nos aferentes durais destes neurônios no gânglio trigeminal. A relação da insônia com a migrânea parece confluir para este mesmo processo fisiopatológico, já que a privação de sono imposta pela insônia seria capaz de gerar a crise migranosa através do aumento do estresse oxidativo.

ABSTRACT BACKGROUND AND OBJECTIVES: Migraine is a type of primary headache, and its pathophysiology remains incomplete. The relationship between sleep and migraine is easily identified by migraine patients. The aim of this review was to investigate the relationship between sleep deprivation and migraine. CONTENTS: A search was made for articles using the terms: “migraine” and “sleep deprivation” in the Pubmed, Biblioteca Virtual da Saúde (Virtual Health Library - LILACS and IBECS) and Scielo databases. The first analysis was based on title and abstract. In cases where the title and abstract were not clear, the article was accessed in its entirety. After applying the exclusion criteria, 49 articles remained. These articles were analyzed and organized into two tables: one for articles that treated sleep as a trigger and the other for articles that explored the pathophysiological relationship between sleep and migraine. CONCLUSION: It is possible that sleep deprivation causes or worsens migraine crisis due to its ability to cause oxidative stress in the brain. This in turn activates TRPA1 receptors located on first-order trigeminal neurons. Activation of these receptors initiates the sensitization process of the trigeminal system that culminates with the antidromic release of calcitonin gene-related peptide in the dural afferents of these neurons in the trigeminal ganglion. The relationship between insomnia and migraine seems to converge with this same pathophysiological process, since sleep deprivation imposed by insomnia would be able to generate a migraine crisis through increased oxidative stress.

https://doi.org/10.5935/2595-0118.20210068 1 downloads

12.

Dementia among older adults living in long-term care facilities: an epidemiological study
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Fagundes, Daniel Ferreira

; Costa, Marcos Túlio

; Alves, Bárbara Bispo da Silva

; Carneiro, Lara

; Nascimento, Osvaldo Jose Moreira

; Leão, Luana Lemos

; Guimarães, André Luiz Sena

; Paula, Alfredo Maurício Batista de

; Monteiro-Junior, Renato Sobral

Dementia & Neuropsychologia

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Dez 2021, Volume 15 Nº 4 Páginas 464 - 469

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A institucionalização tem sido associada ao isolamento social, a alterações psicológicas e cognitivas e à diminuição dos níveis de atividade física em idosos. Objetivos: Estimar a prevalência de demência, declínio cognitivo leve (DCL) e dependência funcional em idosos residentes em duas instituições de longa permanência (ILPI) brasileiras. Métodos: Estudo transversal com 185 idosos de ambos os sexos, com 60 anos ou mais, residentes em duas ILPI. O diagnóstico de DCL e demência foi realizado por meio do Manual Diagnóstico e Estatístico de Transtornos Mentais. Resultados: As taxas de prevalência de demência, DCL e dependência funcional em participantes idosos institucionalizados foram 62,3, 15,1 e 78,9%, respectivamente. Houve redução significativa dos escores do miniexame do estado mental de acordo com o aumento do período de institucionalização nas ILPI e a idade dos idosos (p<0,001). Conclusões: A prevalência de demência e dependência funcional de idosos residentes em ILPI foi mais elevada em comparação com outras populações idosas em todo o mundo. Um período maior de institucionalização está relacionado a maior declínio cognitivo.

ABSTRACT Institutionalization has been associated with social isolation, psychological and cognitive changes, and decreased levels of physical activity in older adults. Objectives: The aim of this study was to estimate the prevalence of dementia, mild cognitive impairment (MCI), and functional dependence in older adults dwelling in two different Brazilian long-term care facilities (LTCFs). Methods: This is a cross-sectional study with 185 older people of both sexes, aged 60 years or over, residing in two LTCFs in the city of Montes Claros-MG, Brazil. The diagnosis of MCI and dementia was performed using the Diagnostic and Statistical Manual of Mental Disorders. Results: Prevalence rates of dementia, MCI, and functional dependence in institutionalized older participants were 62.3, 15.1, and 78.9%, respectively. There was a significant reduction of the Mini-Mental State Examination scores according to the increase of the institutionalization period in LCTFs and the age of older adults (p<0.001). Conclusions: Prevalence of dementia and functional dependence of older adults residing in LTCFs exhibited higher rates compared to the other older population worldwide. A higher institutionalization period is related to a greater cognitive decline.

https://doi.org/10.1590/1980-57642021dn15-040007 1 downloads

13.

Patenting Activity on Functional Foods: A Brazilian Scenario
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Hilachuk, Daniele

; Crisóstimo, Claudia

; Silva, Alvaro José Argemiro da

; Paula, Daniel de

Journal of technology management & innovation

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Ago 2021, Volume 16 Nº 2 Páginas 70 - 81

Resumo: En | Texto: En | PDF: En

Abstract The segment of functional foods is a global trend with expressive growth in recent years. Investments in innovation play an essential role in maintaining the competitiveness of food companies in an increasingly fierce market. This study provides an overview of innovation over the years 2008 to 2020 in the functional foods segment in Brazil by using patenting activity as an indicator of innovation. A patent search was conducted in the National Institute of Intellectual Property (INPI) database to identify patent application records on the following functional foods: (i) gluten-free (ii) lactose-free/low-lactose (iii) probiotic (iv) prebiotic and, (v) enriched/fortified products. The main IPC codes retrieved refer to class A23L (33%), A61K (17%), and A23C (10%), confirming the deposits' relationship with human nutrition. From 2015 on, resident applicants stood out, especially in 2017, with the highest number of deposits in the period. Most patent applications target probiotics (35.3%), followed by fortified/enriched products (25.3%), gluten-free (14.3%), lactose-free/low-lactose (13.3%), and prebiotics (11.8%). Brazilian higher education institutions (HEIs) figure among the top resident patent applicants. University-industry partnerships and research-oriented collaborative networks appear to be a feasible way to foster innovation in the food industry in the country. In summary, the patenting activity of functional foods in Brazil has awakened in recent years, showing trends and opportunities for innovation in the functional food segment.

123 downloads

14.

Seasonally dry tropical forest temporal patterns are marked by floristic stability and structural changes
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Souza, Cléber Rodrigo de

; Santos, Alisson Borges Miranda

; Maia, Vinícius Andrade

; Paula, Gabriela Gomes Pires de

; Fagundes, Nathalle Cristine Alencar

; Coelho, Polyanne Aparecida

; Santos, Paola Ferreira

; Morel, Jean Daniel

; Garcia, Paulo Oswaldo

; Santos, Rubens Manoel dos

CERNE

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2021, Volume 27 elocation e-102355

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Seasonally Dry Tropical Forests (SDTF) are recognized by their great biological diversity, but little is known about their temporal patterns, which may be crucial in a changing world. Here we aimed to characterize the SDTF dynamic patterns in floristic and structural changes, and also to evaluate shifts in dynamic rates and structural attributes such as richness, number of trees and biomass. Our hypothesis is that SDTF tree communities have their dynamic characterized by temporal fluctuations related to an instability pattern, in according to the already found for others tropical forests. For this we used a data of 42 400 m² plots in three fragments in the Brazilian Arboreal Caatinga, measured in 2005, 2010 and 2015. We evaluated temporal changes in richness, species composition, trees density, biomass and rates of tree mortality and recruitment; and also rates of biomass gain and loss. Results: We found a pattern of floristic composition stability, but with changes in structure and dynamics. There was a tree density decrease driven by constant mortality and by recruitment decrease, and biomass increase due to decrease in biomass loss and to increase in biomass gain. The biomass increase was main related to a small set of dominant species that are the most representative in the community dynamics. Conclusion: SDTF dynamics are related to stability in species composition, but with structural changes towards higher biomass stocks. The results are main related to community dynamics and to SDTF attributes such as climatic seasonality that drives the local ecological processes.

https://doi.org/10.1590/01047760202127012355 418 downloads

15.

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 Nº 1 elocation e20200452

Resumo: En | Texto: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

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au	autor
kw	palavras-chave do artigo
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sponsor	financiador
aff_country	código do país de afiliação do autor
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doi	número DOI
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