Abstract Objective: To analyze the prevalence of Mycobacterium leprae detection and the associated factors among social contacts in the school environment of multibacillary cases living in a hyperendemic municipality of the state of Mato Grosso. Methods: Cross-sectional study with 236 social contacts of multibacillary leprosy from public schools and residents in Cuiabá (Mato Grosso) in 2018. The sources of information were interviews and nasal swab tests for molecular analysis by polymerase chain reaction - PCR. For the prevalence ratio estimates, crude and adjusted analyses were performed using robust Poisson regression and their respective confidence intervals (95% CI). The ArcGIS 9.1 software was used for the geographic distribution analyses. Results: The prevalence of detection of M. leprae in social contacts was 14%. A total of 63.6% of the schools surveyed had 5.1% to 50% of the social contacts of leprosy with positive PCR. The analysis of the geographic distribution in the neighborhoods showed a high prevalence of infection, being higher than 50% in some localities. The highest proportion of positive results occurred in the northern region of the city and from a precarious socioeconomic class. Conclusion: The results showed a high prevalence of detection of M. leprae among social contacts in areas with poor socioeconomic conditions. In these regions, there is a greater risk of

RESUMO O futebol está presente no cotidiano dos brasileiros, envolvendo relações sociais e econômicas. Os Programas Sócio-Torcedor (PST) são estratégias de marketing de relacionamento que buscam aproximar clubes e torcedores. O objetivo deste artigo é analisar a estrutura de valor percebido, baseada no perfil sociodemográfico, a partir dos atributos oferecidos pelos PSTs dos clubes classificados na série A do Campeonato Brasileiro de 2016. Os dados foram coletados virtualmente e a população constituída por torcedores das equipes selecionadas. A análise foi feita utilizando a análise conjunta. Verificou-se que tanto para a amostra geral, quanto pelos perfis sociodemográficos, o desconto nos ingressos e o preço dos PSTs são, principalmente, os atributos percebidos com maior valor. O desenvolvimento deste trabalho contribuiu com a proposta de um instrumento capaz de descrever a percepção de valor nos PSTs. Em termos acadêmicos, contribuiu como um estudo de marketing esportivo na área da Administração, além de também se aplicar como uma ferramenta para os gestores dos times.

ABSTRACT Football is ever present in Brazilians’ lives, and, more than a game, it also involves social and economic relations. Fan Membership Programs (FMPs), based on relationship marketing strategies, are ways to bring the clubs closer to their fans. This paper aims to analyze the perceived value structure of FMPs, based on sociodemographic profiles, starting with FMP attributes of the 2016 Brazilian Football Championship series A classified clubs. The data was collected online, and the population consisted of fans of the selected teams. The data was analyzed using the multivariate technique of Conjoint Analysis. It was verified that the general sample for different sociodemographic profiles, the ticket discounts, and prices of the FMP are the most valued attributes. This paper contributes to academy and practice by presenting a capable instrument to describe FMPs’ value perception. In academic terms, it contributes as a sports marketing management study. In addition, the paper could also apply as a tool for the Football clubs’ managers.

RESUMO Objetivo: Descrever os resultados parciais de estudo em pacientes com câncer de reto submetidos a tratamento neoadjuvante com quimioterapia e radioterapia quanto à taxa resposta clínica completa, sobrevida livre de doença, função anorretal e qualidade de vida. Material e métodos: Estudo prospectivo desde junho 2015 até junho de 2018, em paciente com adenocarcinoma de reto baixo ou médio e estadio clínico II ou III tratados com RT/QT (IMRT 54 Gy em 6 semanas) concomitante a 5-Fuorouracil (5-FU) 380 mg/m2 e ácido folínico (LV) 20 mg/m2 por 5 dias nas primeira e quinta semanas e dois ciclos após RT (5-FU 400 mg/m2 e LV 20 mg/m2) a cada 28 dias. Após o tratamento, realizou-se exame clínico, retossigmoidoscopia, RNM de pelve, TC de tórax e abdômen superior e dosagem de CEA. Naqueles com Resposta Clínica Incompleta (iRC) procedeu-se à cirurgia de ressecção. Aqueles com Resposta Completa (cRC) estão em observação (wait and see policy). Manometria e escalas de função esfincteriana e qualidade de vida foram obtidas antes e após 30 e 90 dias do término do tratamento. Resultados: Até junho de 2018, recrutaram-se 11 pacientes. Um foi excluído da análise, pois apresentou toxicidade severa sugestiva de deficiência de DPD após o primeiro ciclo de QT. Todos os demais concluíram o tratamento. Toxicidades graus 3/4 relacionadas à QT ocorreram dois pacientes, reduzindo-se sua dose. Sete (70%) apresentaram iRC, submetendo três à retossigmoidectomia cuja avaliação anatomopatológica evidenciou Resposta Completa (pRC) em dois casos (28,5%). Três (30%) apresentaram cRC e estão sem evidência de doença com seguimento médio de 19 meses. Houve melhora da função anorretal e da qualidade de vida. Conclusões: Avanços no tratamento neoadjuvante dos tumores de reto contribuíram para melhores taxas de pRC. Novos paradigmas promovem crescentes índices de cRC, o que possibilitaria a preservação do órgão e consequente redução da morbidade cirúrgica.

ABSTRACT Objective: To describe the partial results of a study in patients with rectal cancer who underwent neoadjuvant treatment with chemotherapy and radiotherapy regarding the rate of complete clinical response, disease-free survival, anorectal function, and quality of life. Material and methods: This was a prospective study from June 2015 to June 2018, in patients with low- or mid-rectum adenocarcinoma and clinical stage II or III, treated with radiotherapy and chemotherapy (IMRT 54 Gy for six weeks) concomitant with 5-fluorouracil (5-FU) 380 mg/m2 and folinic acid (LV) 20 mg/m2 for five days in the first and fifth weeks and two cycles after radiotherapy (5-FU 400 mg/m2 and LV 20 mg/m2) every 28 days. After the treatment, clinical examination, rectosigmoidoscopy, pelvic magnetic resonance imaging, chest and upper abdomen computed tomography, and CEA testing were performed. Resection surgery was performed in those with incomplete clinical response (iCR). Those with complete clinical response (cCR) are under observation (wait-and-see policy). Manometry and scintigraphic function and quality of life scales were collected before treatment and at 30 and 90 days after the end of treatment. Results: As of June 2018, 11 patients were recruited. One was excluded from the analysis for presenting severe toxicity, suggestive of dihydropyrimidine dehydrogenase (DPD) deficiency, after the first chemotherapy cycle. All others completed the treatment. Two patients presented toxicity grade 3/4 related to chemotherapy and had their doses reduced. Seven patients (70%) presented iRC; three underwent rectosigmoidectomy, and the anatomopathological evaluation indicated complete pathological response in two cases (28.5%). Three (30%) presented cCR and did not present evidence of disease after a mean follow-up of 19 months. Patients presented improvement of anorectal function and quality of life. Conclusions: Advances in the neoadjuvant treatment of rectal tumors contributed to better rates of complete pathological responses. New paradigms promote an increase in the complete clinical response rates, which would allow organ preservation and consequent reduction of surgical morbidity.

As respostas do organismo humano submetido a estímulos diversos, mensuradas através de parâmetros de performance, têm sido objeto de estudo a fim de aprimorar os métodos de treinamento. O objetivo deste estudo foi investigar os efeitos do treinamento neuromuscular na capacidade cardiorrespiratória e composição corporal de atletas de voleibol. Foram avaliadas 11 mulheres, antes e após 12 semanas de treinamento, referente à fase preparatória do ciclo anual de treinamento. O protocolo experimental constou de avaliação da composição corporal (percentual de gordura, massa magra e a gordura corporal) e da aptidão cardiorrespiratória por meio de ergoespirometria em esteira rolante com protocolo contínuo e carga crescente, na qual se determinaram o consumo máximo de oxigênio, a frequência cardíaca máxima, o limiar anaeróbio, a frequência cardíaca do limiar anaeróbio e a velocidade do limiar anaeróbio. O treinamento teve frequência de cinco dias por semana dividido em duas sessões: uma de treinamento de força e outra de treinamento técnico e tático. Após o período estudado ocorreram aumentos (p < 0,05) no consumo máximo de oxigênio (6,5%), no limiar anaeróbio (17,5%), na velocidade do limiar (15,3%) e redução (p < 0,05) na frequência cardíaca máxima (-3,1%). Também houve redução (p < 0,05) no percentual de gordura (-8,2%), na gordura corporal (-7,4%) e aumento (p < 0,05) na massa magra (3,2%). Conclui-se que o treinamento neuromuscular realizado na fase preparatória de treinamento contribuiu para o aumento da capacidade cardiorrespiratória e massa magra e para redução do percentual de gordura e a gordura corporal das atletas de voleibol.

The responses of the human body submitted to several stimuli measured by performance parameters have been object of studies in order to improve training methods. The aim of this study was to investigate the effects of the neuromuscular training in the cardiorespiratory fitness and body composition of volleyball athletes. Eleven women were assessed before and after 12 weeks of training, concerning the preparatory phase of the annual training cycle. The experimental protocol consisted of assessment of the body composition (fat percentage, lean mass and body fat) and of the cardiorespiratory fitness through ergospirometry on treadmill with continuous protocol and increasing load, in which the oxygen maximal uptake, maximum heart rate, anaerobic threshold, heart rate threshold and anaerobic threshold velocity were determined. The training was carried out five times per week and was divided in two sessions: one strength training and the another technical and tactical training. After the studied period, increase (p < 0.05) in oxygen maximal uptake (6.5%), anaerobic threshold (17.5%), threshold velocity (15.3%) and lean mass (3.2%) was observed. Reduction (p< 0.05) in maximum heart rate (- 3.1%), fat percentage (-8.2%) and body fat (-7.4%) was observed. It is concluded that neuromuscular training performed in the preparatory phase contributed to increase in the cardiorespiratory fitness and lean mass as well as decrease in fat percentage and body fat of volleyball athletes.