ABSTRACT Objective To evaluate the relationship between nutritional parameters and clinical factors and the outcome of patients diagnosed with COVID-19. Methods This is a prospective longitudinal study involving patients with COVID-19 infection admitted to a University Hospital in Pernambuco. The sample consisted of individuals aged ≥20 years who tested positive for COVID-19 infection. Nutritional risk was assessed using the recommended screening procedure for this group and the nutritional status using the Body Mass Index. Demographic and clinical variables were transcribed from the medical records. Result There was a predominance of adult inpatients between 20 and 59 years of age (95% CI: 64.6-76.0); nutritional risk was observed in 91.6% of patients and overweight in 58.9% of patients. Age ≥60 years (p=0.03), presence of malignancies and inadequate nutrition (p<0.001) were independent risk factors for in-hospital death. It was also observed that only arterial hypertension (OR 2.34, 95% CI 1.32-4.13, p=0.003) and overweight (OR 1.84, 95% CI 1.05-3.21, p=0.032) were considered independent risk factors for admission of the patients in the Intensive Care Unit. Conclusion Although overweight is a risk factor for admission in the Intensive Care Unit, it was not possible to observe it as a factor for mortality, requiring further studies to determine the mechanisms that interfere in the association between obesity and mortality in those patients.

RESUMO Objetivo Avaliar a relação dos parâmetros nutricionais e fatores clínicos com o desfecho dos pacientes diagnosticados com COVID-19. Métodos Trata-se de um estudo longitudinal prospectivo envolvendo pacientes com infecção por COVID-19 internados em um Hospital Universitário de Pernambuco. A amostra foi constituída por indivíduos com idade ≥20 anos que tiveram resultado positivo para infecção por COVID-19. O risco nutricional foi avaliado por meio de triagem recomendada para este grupo e o estado nutricional por meio do Índice de Massa Corpórea. As variáveis demográficas e clínicas foram transcritas dos prontuários. Resultados Houve predomínio de pacientes adultos entre 20 e 59 anos (95% IC: 64,6-76,0) internados, o risco nutricional foi observado em 91,6% e o excesso de peso em 58,9% dos pacientes. A idade >60 anos (p=0,03), a presença de câncer e aporte nutricional inadequado (p<0,001) foram fatores de risco independente para morte hospitalar. Observou-se também que apenas a hipertensão arterial (OR 2,34, 95% IC 1,32-4,13, p=0,003) e o excesso de peso (OR 1,84, 95% IC 1,05-3,21, p=0,032) foram considerados fatores de risco independentes para a internação do paciente na Unidade de Terapia Intensiva. Conclusão Embora o excesso de peso seja um fator de risco para admissão na Unidade de Terapia Intensiva, não foi possível observá-la como um fator para mortalidade, se fazendo necessários estudos para determinar os mecanismos que interferem na associação entre a obesidade e letalidade desses pacientes.

Abstract The objective of this study is to validate the specific questionnaire for Hepatitis B HBQOL (Hepatitis B Quality of Life Instrument, version 1.0) for the Brazilian version, in addition to testing its applicability in patients with hepatitis B under treatment and comparing the quality of life between patients using first-line drugs (tenofovir and entecavir). For the validation, the back-translation technique was used in a sample of 47 patients. Factor analysis was performed between the items in each domain of the questionnaire and the internal consistency was calculated using Cronbach's α coefficient. In assessing the applicability of the validated questionnaire, interviews were carried out with 124 patients. Sociodemographic and treatment data were collected to characterize the sample and perform correlation analyzes. The results demonstrate that the Brazilian version of the questionnaire was successfully validated. In the analysis carried out among the 124 patients, the domains psychological well-being and stigma obtained the highest scores in quality of life and the lowest level of education conferred better results in these two domains. The comparison between tenofovir and entecavir showed no significant difference in patients' quality of life. The use of this validated instrument can make therapeutic decisions more rational.

Abstract This study aimed to investigate the antimicrobial activity of kefir fermented fruit by-products against strains of Alicyclobacillus spp., and determine their chemical characterization and antioxidant activity. According to the results, extracts fermented for a longer period (72 h) showed greater inhibition, and the extract of acerola by-product fermented for 72 h achieved the best results. For all strains, the Minimal Inhibitory Concentration (MIC) was 0.78%, except for A. acidocaldarius subsp. rittmannii, (1.56%). The same applies to the Minimal Bactericidal Concentration (MBC), in which 1.56% of the extract was capable of inactivating A. cycloheptanicus and A. acidocaldarius. In addition, damages to the structure of the microorganisms caused by the extracts were detected by Scanning Electron Microscopy. Metabolite identification through liquid chromatography (UHPLC-Qtof-MS) showed that the fermented extracts had a greater number of compounds compared to the non-fermented ones, such as glucuronic, succinic and glutaric acids. In conclusion, the extracts of fruit by-products showed to have bioactive properties, such as antibacterial potential and antioxidant activity against the Alicyclobacillus strains tested in this study, not to mention the value added by the use of a food by-product.

Resumo O presente estudo consiste na caracterização e na seleção de descritores morfoagronômicos mínimos em genótipos de Passiflora cincinnata in situ. Foram utilizados 41 descritores morfoagronômicos quantitativos, divididos em “Planta e Folha”, “Floral” e “Fruto”. Utilizou-se a análise de componentes principais com o objetivo de eliminar descritores que tivessem menor importância no estudo de dissimilaridade multivariada entre genótipos. Foi realizada a formação de grupos por meio do método de agrupamento hierárquico de Ward. Foi estimada a importância dos caracteres por meio da participação dos componentes pelo método de Singh (1981), com o intuito de verificar a similaridade entre variáveis de menor participação dos componentes. Para o grupo de descritores “Planta e Folha”, as características que apresentaram as maiores contribuições relativas foram: largura máxima da folha (76,1%) e comprimento da lâmina foliar (17,2%). Para o grupo de descritores “Floral”, as características que apresentaram as maiores contribuições relativas foram: comprimento do pedicelo (42,1%), diâmetro da ponta da corona (32,6%) e comprimento da pétala (11,8%). Para o grupo de descritores “Fruto”, a característica que apresentou a maior contribuição relativa foi: número de sementes por fruto (89,2%). A partir dos resultados obtidos, pode-se inferir que, dos 41 descritores, apenas 15 se mostraram relevantes para a avaliação da diversidade genética entre os indivíduos da população. Estes descritores foram: acidez titulável, comprimento da bráctea, comprimento da lâmina foliar, comprimento da pétala, comprimento da sépala, comprimento do pedicelo, comprimento dos anéis dos filamentos corona, diâmetro da ponta da corona, diâmetro longitudinal do fruto, largura da sépala, largura máxima da folha, número de frutos, número de sementes por fruto, peso da casca e massa do fruto.

Abstract The present study consists of the in situ characterization and selection of minimal morphoagronomic descriptors in Passiflora cincinnata genotypes. Forty-one quantitative morphoagronomic descriptors were used, divided in “Plant and Leaf”, “Floral” and “Fruit”. Principal component analysis were used to eliminate descriptors that were less important in the study of multivariate dissimilarity among genotypes. The formation of groups was carried out using Ward’s hierarchical grouping method. The importance of the characters was estimated through the participation of the components by Singh’s method (1981) in order to verify the similarity between lower participation variables in the components. For the set of descriptors “Plant and Leaf” the characteristics that presented the greatest relative contributions were: maximum leaf width 76.1% and leaf blade length 17.2%. For the set of descriptors “Floral” the characteristics that presented the greatest relative contributions were: pedicel length 42.1%, corona tip diameter 32.6% and petal length 11.8%. For the set of descriptors “Fruit” the characteristic that presented the greatest relative contribution was: number of seeds per fruit 89.2%. From the results obtained, we can infer that from the 41 descriptors, only 15 were relevant for the evaluation of the genetic diversity among the individuals of the population. These descriptors were: titratable acidity, bract length, leaf blade length, petal length, sepal length, pedicel length, corona filament ring length, corona tip diameter, fruit longitudinal diameter, sepal width, maximum leaf width, number of fruits, number of seeds per fruit, bark weight and fruit mass.