Abstract Mucopolysaccharidosis III (MPS III) is a rare inherited metabolic disease primarily affecting the central nervous system, leading to developmental and/or speech regression. Early diagnosis of the disease is important to introduce appropriate management measures and to optimize therapeutic outcomes. The diagnosis of MPS III is often significantly delayed due to the rarity of the disease, the more attenuated somatic presentation compared to other MPS types, and the symptom overlap with other developmental disorders. To shorten the time to diagnosis, a list of eight early signs and symptoms was identified through an expert system approach by a global, multidisciplinary working group of 13 specialists with expertise in various aspects of MPS and developmental disorders and three parents of MPS III patients. Coarse facial features and persistent hirsutism or prominent, thick eyebrows were identified as the most important MPS III early signs. The list of eight early MPS III signs and symptoms is the first step towards the development of a clinical algorithm aiming to identify neonates and infants with MPS III before the onset of neurocognitive damage, ultimately shortening the diagnostic journey of MPS III patients.

Resumen La ansiedad y la insatisfacción corporal son factores de riesgo para los trastornos de conducta alimentaria y de la ingesta de alimentos. La presente investigación busca analizar los niveles de ansiedad e insatisfacción corporal, y su relación con las diferencias en función del género, curso y centro de estudios en 516 universitarios de Burgos, España -el 42.8 % fueron varones y el 57.2 %, mujeres; M = 21.7 años (DT = 4.1)-, utilizando un muestreo aleatorio estratificado. Para ello, se realizó un estudio descriptivo transversal en el que se aplicó el Cuestionario de Ansiedad Estado-Rasgo y la subescala Insatisfacción Corporal del Inventario de Trastornos de Conducta Alimentaria. Como resultados, alrededor del 20 % de los participantes presentó niveles altos de ansiedad, aunque no se encontraron diferencias por género, curso o centro; adicionalmente, el 61.4 % presentó alta o moderada insatisfacción corporal, principalmente si eran mujeres, personas ansiosas, o de segundo curso en la universidad. También se encontró interrelación entre estos factores, por lo cual en algunos universitarios se pudo identificar determinado riesgo para la aparición de trastornos de la conducta alimentaria y de la ingesta de alimentos.

Abstract Anxiety and body dissatisfaction are risk factors for eating behavior disorders (ACT). This research analyzes the levels of anxiety and body dissatisfaction, the relationship between these variables, and the differences according to gender, course and center in 516 university students of Burgos (Spain), using a stratified random sampling. 42.8 % were males and 57.2 % females, M = 21.7 years (SD = 4.1). Was carried descriptive study a cross-sectional. The State-Trait Anxiety Inventory and the subscale Body Dissatisfaction of the Eating Disorders Inventory are applied. About 20 % of participants have high levels of anxiety, not finding differences by gender, course and center. 61.4 % present high and median body dissatisfaction, mainly women, the more anxious and those of 2nd. In addition, there is an interrelation between factors. Therefore, in some students there are conditioning factors that are risk factors for the appearance of eating behavior disorders.

Resumo A ansiedade e a insatisfação corporal são fatores de risco dos transtornos de comportamento alimentar e da ingestão de alimentos. Esta pesquisa procura analisar os níveis de ansiedade e de insatisfação corporal, bem como sua relação com as diferenças em função do gênero, do curso e do centro de estudos em 516 universitários de Burgos, Espanha - 42.8 % homens e 57.2 %, mulheres; M = 21.7 anos (DP = 4.1) -, utilizando uma amostra aleatória estratificada. Para isso, foi realizado um estudo descritivo transversal, no qual foi aplicado o Inventário de Ansiedade Traço-Estado e a subescala Insatisfação Corporal do Inventário de Transtornos de Comportamento Alimentar. Como resultados, ao redor de 20 % dos participantes apresentaram níveis altos de ansiedade, embora não se tenham encontrado diferenças por gênero, curso ou centro de estudos; além disso, 61.4 % apresentaram alta ou moderada insatisfação corporal, principalmente mulheres, pessoas ansiosas ou de segundo curso na universidade. Também foi encontrada inter-relação entre esses fatores, razão pela qual, em alguns universitários, pôde ser verificado determinado risco para o surgimento de transtorno de comportamento alimentar e da ingestão de alimentos.

Abstract Eating disorders (ED) are a public health problem which it has been increasing. The aim of this study was to estimate the vulnerability of university students to an ED. We worked with a probabilistic sample of 561 students (M age = 21.7; SD = 4.1), 42.8% men and 57.2% women. They completed the Inventory Eating Disorder-Reference criterion (EDI-3-RF), also we took anthropometric measures. The results show that: women have a significantly more obsession with thinness and body dissatisfaction; the students under 20years old showed significant more bulimic behaviors; men prefer to do physical exercise as a way to control their weight; about 7.7% should be referred to a specialized center for having low weight along with excessive concern about food and weight. It is concluded that it is necessary to implement preventive programs and intervention measures aimed towards to the university students who promote healthy eating habits, improve the perception of their body image and diminish the obsessive preoccupation with thinness.

Resumen Los trastornos de la conducta alimentaria (TCA) constituyen un problema de salud pública que ha venido incrementando. El objetivo de este estudio fue estimar la vulnerabilidad de los estudiantes universitarios a presentar un TCA. Se trabajó con una muestra probabilística de 561 estudiantes (M edad = 21.7; DE =4.1), 42.8% varones y 57.2% mujeres. Los datos fueron recabados con base al Inventario de Trastornos de la Conducta Alimentaria-Criterio de Remisión (EDI-3-RF), además de registrar algunos indicadores antropométricos. Destacan los siguientes resultados: las mujeres presentaron mayor obsesión por la delgadez e insatisfacción corporal que los varones; las conductas bulímicas estuvieron más presentes en estudiantes menores de 20 años; los varones recurren en mayor medida al ejercicio físico como forma de control del peso; 7.7% presentaron bajo peso y preocupación excesiva por la comida y el peso, condición que amerita remisión a atención especializada. Resulta apremiante reforzar los esfuerzos encaminados a la implementación de estrategias de prevención e intervención dirigidas específicamente a los estudiantes universitarios, a través del diseño de programas destinados a promover hábitos de alimentación saludables, mejorar la percepción de la imagen corporal y disminuir la preocupación obsesiva por la delgadez.

Objetivo Estimar la frecuencia de factores de riesgo asociados a enfermedades cardiovasculares en población universitaria joven en Cartagena, Bolívar. Métodos Estudio de corte transversal para establecer la magnitud de sobrepeso, obesidad, dislipidemia, inactividad física y consumo de tabaco en 301 estudiantes de una Universidad de la ciudad de Cartagena. El muestreo fue aleatorio simple sin reemplazo. El Cuestionario Internacional de Actividad Física (IPAQ), formato corto; se realizó la determinación de Colesterol total, Triglicéridos, Colesterol HDL y Colesterol LDL. Para determinar las asociaciones entre los factores de riesgo cardiovascular y el género se usó las pruebas X2 y T. Resultados El 34,2 % de los estudiantes encuestados presentaron alteración del índice de Masa corporal. El 64,1 % registraron inactividad física y 23,9 % de los estudiantes encuestados fuma. El lípido que presentó mayor prevalencia de niveles alterados fue el triglicérido (24,6 %). Se encontraron diferencias estadísticamente significantes en los análisis por género, niveles de actividad física, consumo de tabaco y niveles del colesterol HDL y de triglicéridos (p<0,05). Conclusiones Los factores de riesgo para enfermedad cardiovasculares analizados en la población joven de este estudio muestran patrones similares a los de la región en donde existe evidencia de transición epidemiológica y demográfica. Estos hallazgos sugieren la necesidad de implementar modelos de promoción y prevención oportunos que permitan reducir la carga de enfermedad y muerte asociadas con enfermedades crónica.

Objective Estimating the frequency of cardiovascular disease-associated risk factors in a university student population in Cartagena, Bolívar. Methods A cross-sectional survey was conducted to establish the frequency of being overweight, obesity, dyslipidaemia, physical inactivity and smoking habits in 301 students from the University of Cartagena. Simple random sampling was carried out without replacement. The International Physical Activity Questionnaire-short form (IPAQ-sf) was applied in addition to lab tests for evaluating total cholesterol, triglycerides, HDL and LDL cholesterol. The main analysis was carried out for establishing the possible risk factors associated with heart diseases; a 0.05 statistical significance level was used. Results 34.2 % of the students in the survey had alterations regarding their body mass index. 64.1 % of the sample population were physically inactive and 23.9 % stated that they smoked. Triglycerides had the highest lipid prevalence (24.6 %). Statistically significant differences were found regarding gender, recorded statistically significant differences when were related to physical activity levels, smoking and HDL cholesterol and triglyceride levels (p<0.05). Conclusions Cardiovascular risk factors in this student population revealed similar patterns to those found in the Caribbean region which have shown epidemiological and demographic transition, as reported by national and local health services. These findings thus strongly suggest the need for implementing opportune health promotion and prevention models for reducing the burden of non-communicable disease and chronic disease-associated death.

Objective Estimating the frequency of cardiovascular disease-associated risk factors in a university student population in Cartagena, Bolívar. Methods A cross-sectional survey was conducted to establish the frequency of being overweight, obesity, dyslipidaemia, physical inactivity and smoking habits in 301 students from the University of Cartagena. Simple random sampling was carried out without replacement. The International Physical Activity Questionnaire-short form (IPAQ-sf) was applied in addition to lab tests for evaluating total cholesterol, triglycerides, HDL and LDL cholesterol. The main analysis was carried out for establishing the possible risk factors associated with heart diseases; a 0.05 statistical significance level was used. Results 34.2 % of the students in the survey had alterations regarding their body mass index. 64.1 % of the sample population were physically inactive and 23.9 % stated that they smoked. Triglycerides had the highest lipid prevalence (24.6 %). Statistically significant differences were found regarding gender, recorded statistically significant differences when were related to physical activity levels, smoking and HDL cholesterol and triglyceride levels (p<0.05). Conclusions Cardiovascular risk factors in this student population revealed similar patterns to those found in the Caribbean region which have shown epidemiological and demographic transition, as reported by national and local health services. These findings thus strongly suggest the need for implementing opportune health promotion and prevention models for reducing the burden of non-communicable disease and chronic disease-associated death.

Objetivo Estimar la frecuencia de factores de riesgo asociados a enfermedades cardiovasculares en población universitaria joven en Cartagena, Bolívar. Métodos Estudio de corte transversal para establecer la magnitud de sobrepeso, obesidad, dislipidemia, inactividad física y consumo de tabaco en 301 estudiantes de una Universidad de la ciudad de Cartagena. El muestreo fue aleatorio simple sin reemplazo. El Cuestionario Internacional de Actividad Física (IPAQ), formato corto; se realizó la determinación de Colesterol total, Triglicéridos, Colesterol HDL y Colesterol LDL. Para determinar las asociaciones entre los factores de riesgo cardiovascular y el género se usó las pruebas X2 y T. Resultados El 34,2 % de los estudiantes encuestados presentaron alteración del índice de Masa corporal. El 64,1 % registraron inactividad física y 23,9 % de los estudiantes encuestados fuma. El lípido que presentó mayor prevalencia de niveles alterados fue el triglicérido (24,6 %). Se encontraron diferencias estadísticamente significantes en los análisis por género, niveles de actividad física, consumo de tabaco y niveles del colesterol HDL y de triglicéridos (p<0,05). Conclusiones Los factores de riesgo para enfermedad cardiovasculares analizados en la población joven de este estudio muestran patrones similares a los de la región en donde existe evidencia de transición epidemiológica y demográfica. Estos hallazgos sugieren la necesidad de implementar modelos de promoción y prevención oportunos que permitan reducir la carga de enfermedad y muerte asociadas con enfermedades crónica.