Abstract The Ramal Trem Turístico (RTT), a 17 km long railway between Ouro Preto and Mariana, a centenary line, currently in operation as a tourist attraction with historical importance. The railroad was built along a steep region, with hundreds of slopes, and eventually slope instabilities compromised the tour. In linear infrastructure projects, a risk assessment is an important tool for risk management, mapping it is the first step. After slope instabilities in 2019, a risk map was elaborated early 2021 for RTT. Risk is obtained by multiplying the probability of a certain event to occur by its consequences. Define its value in a quantitative way demands geotechnical investigation, for precise failure probability. Regardless of its importance, its determination needs high resources, specially for linear infrastructure in a region with heterogeneous geology and pedology. Therefore, for the risk mapping of the RTT, a semi-empirical methodology was adopted, based on the Rockfall Hazard Rating System (RHRS), originally developed for rocky slopes, and adapted for the registration of slopes in soil and in landfill. The aim of the method is to register a series of slope characteristics to be assigned a specific score, framing the slopes within pre-defined risk classes. This methodology was applied to this 17 km railway and identified 286 slopes. In January 2022 extreme rainfall triggered slopes instabilities at RTT. A critical analysis of this event shows a satisfactory result for the applied methodology. Risk mapping is an important tool for risk management, helping to prioritize investments in mitigation measures.

Introduction: Invasive ductal carcinoma corresponds to the most common histological type of the breast, coexisting with different forms of clinical evolution, histological grading, expression of certain tissue markers and genomic profiles that seek a better understanding of the disease. Objectives: To analyze the correlation of β-catenin and AXL markers with tumor aggressiveness, with reference to overall survival, tumor progression and histopathological prognostic factors. Methods: A study of 101 samples of invasive ductal mammary carcinoma was performed. Those with a diagnosis of ductal type, initially submitted to biopsy or definitive surgical treatment, were included. For control purposes, 20 samples of intraductal carcinoma, 35 of breast fibroadenoma and 10 of breast tissue without any alteration were included. Those undergoing neoadjuvant chemotherapy, those without a tumor sample prior to chemotherapy, those lost to follow-up, and those with incomplete data, were excluded. Results: When the β-catenin expression was analyzed, it was negative. As for AXL, different degrees of expression were observed without statistical significance between them. Conclusion: When analyzing invasive ductal breast adenocarcinoma in TMA, there was no correlation in the expression of ß-Catenin and AXL when compared to overall survival, tumor progression and histological grade.

Introdução: O carcinoma ductal invasor corresponde ao tipo histológico mais comum da mama coexistindo com formas diferentes de evolução clínica, graduação histológica, expressão de determinados marcadores teciduais e perfis genômicos que procuram melhor entendimento da doença. Objetivos: Analisar a correlação dos marcadores β-catenina e AXL com a agressividade tumoral, tendo como referência a sobrevida global, progressão tumoral e fatores prognósticos histopatológicos. Métodos: Foi realizado estudo de 101 amostras de carcinoma mamário ductal invasor. Foram incluídas aquelas com diagnóstico do tipo ductal, submetidas inicialmente à biópsia ou tratamento cirúrgico definitivo. Incluiu-se para fins de controle 20 amostras de carcinoma intraductal, 35 de fibroadenoma mamário e 10 de tecido mamário sem qualquer alteração. Foram excluídos os submetidos à quimioterapia neoadjuvante, que não tivessem amostra tumoral prévia ao tratamento quimioterápico, que perderam o seguimento, e com dados incompletos. Resultados: Quando analisada a expressão da β-catenina, foi negativa. Quanto ao AXL foram observados diferentes graus de expressão sem significância estatística entre eles. Conclusão: Quando analisados adenocarcinoma mamário do tipo ductal invasor em TMA não houve correlação na expressão de ß-catenina e AXL quando comparados a sobrevida global, progressão tumoral e grau histológico.

Introduction: The limits for the viability of survival in preterm births have increased. Complications inherent to the immaturity of the systems lead to metabolic alterations. Physical activity programs have been applied in neonatal ICUs, seeking improvement in bone mineralization, weight gain and increase in leptin levels. Objectives: To analyze the serum levels of leptin and bilirubin in premature infants exposed to phototherapy, in order to establish a safe practice of joint mobilization. Method: Analytical, longitudinal, prospective cohort study with a sample composed of 108 parturients and their respective PTNBs arranged in 2 groups: control group 28 NBs and study group 23 NBs. The variables studied were: weight, gestational age, BMI, sex, serum levels of leptin in the placenta, serum levels of bilirubin, reticulocytes, 12 h, 24 h and rebound leptin, nutrition, body mass index. Results: Regarding weight, gestational age, BMI and sex, the sample was homogeneous. Regarding the concentration of leptin in the placenta and in the 12 h NB, there were no statistically significant differences. When the leptin concentrations were analyzed at the different evaluation moments of the study group, a statistically 3 significant difference (plt;0.001) was found between all moments. Comparing assessment 2 to 2 of the study group, a statistically significant difference was found between placentas at all times. There was a trend of difference between 24 h with phototherapy and rebound, the same observed in the control group. There was no difference in leptin distributions in relation to placental time and 12 h between groups. Comparing each group with a leptin value lower than 0.1 the placental time and 12 h showed difference. There was a difference between 24 h with phototherapy and rebound. As for reticulocytes, there was a tendency to decrease in relation to the beginning/rebound (plt;0.004). There was no correlation between leptin/bilirubin, leptin/reticulocytes, onset of nutrition and BMI/leptin. Conclusion: Phototherapy does not increase serum leptin levels in PTNBs, making joint mobilization a safe practice in this group.

Introdução: Os limites para a viabilidade de sobrevida em nascimentos prematuros têm aumentado. As complicações inerentes à imaturidade dos sistemas acarreta alterações metabólicas. Programas de atividade física têm sido aplicados em UTIs neonatais, buscando melhora na mineralização óssea, ganho de peso e aumento dos níveis de leptina. Objetivos: Analisar os níveis séricos de leptina e bilirrubina em prematuros expostos à fototerapia, a fim de estabelecer prática segura de mobilização articular. Método: Estudo analítico, longitudinal, prospectivo do tipo coorte com amostra composta por 108 parturientes e seus respectivos RNPT dispostos em 2 grupos: grupo controle 28RNs e grupo estudo 23RNs. As variáveis estudadas foram: peso, idade gestacional, IMC, sexo, dosagem sérica de leptina na placenta, dosagem sérica de bilirrubina, reticulócitos, leptina de 12 h, 24 h e rebote,nutrição, índice de massa corporal. Resultados: Quanto ao peso, idade gestacional, IMC e sexo, houve homogeneidade da amostra. Quanto à concentração de leptina na placenta e no RN 12 h não houve diferenças estatisticamente significativas. Quando analisadas as concentrações de leptina nos diferentes momentos de avaliação do grupo estudo, encontrou-se diferença estatisticamente significativa (plt;0,001) entre todos os momentos. Comparando avaliação 2 a 2 do grupo estudo, encontrou-se diferença estatisticamente significativa entre placenta em todos os momentos. Verificou-se tendência de diferença entre 24 h com fototerapia e rebote, o mesmo observado no grupo controle. Não houve diferença nas distribuições da leptina em relação ao momento placenta e 12 h entre os grupos. Comparando cada grupo com o valor de leptina inferior a 0,1 o momento placenta e 12 h apresentaram diferença. Houve diferença entre 24 h com fototerapia e rebote. Quanto aos reticulócitos ocorreu tendência à diminuição em relação ao início/rebote (plt;0,004). Não houve correlação entre leptina/bilirrubina, leptina/reticulócitos, início da nutrição e IMC/leptina. Conclusão: A fototerapia não aumenta níveis séricos de leptina em RNPT, tornando a mobilização articular prática segura neste grupo.

RESUMO Objetivo: O Consenso Brasileiro de Viscossuplementação do Quadril visa gerar uma fonte referencial a partir do conhecimento teórico e da experiência clínica de especialistas da área. Métodos: Um painel multidisciplinar foi formado com quinze especialistas (médicos do esporte, ortopedistas, fisiatras e reumatologistas), com base na experiência clínica e acadêmica no uso da viscossuplementação do quadril. Foram elaboradas, discutidas e votadas doze afirmativas. Cada membro do painel deu um valor entre 0 e 10 numa escala tipo Likert, especificando seu nível de concordância com a afirmação. Resultados: O painel chegou a um consenso sobre diversos aspectos da viscossuplementação do quadril, destacando-se: a melhor indicação é para tratar artrose de quadril leve a moderada; pode ser indicada para casos graves; os resultados podem variar de acordo com o viscossuplemento utilizado; não deve ser realizada como procedimento isolado, mas em conjunto com outras medidas reabilitadoras e farmacológicas; a melhor técnica para infiltração no quadril deve se basear nas referências anatômicas combinadas com guiagem por imagem; a viscossuplementação do quadril é um procedimento custo-efetivo. Conclusão: A viscossuplementação é uma alternativa terapêutica segura e eficaz na osteoartrite do quadril, mesmo em casos graves. Recomenda-se o uso de métodos guiados. Nível de Evidência V, Opinião do Especialista.

ABSTRACT Objective: The Brazilian Consensus on Hip Viscosupplementation aims to generate a referential and consensual source from the theoretical knowledge and clinical experience of specialists in the field. Methods: A multidisciplinary panel was formed with 15 specialists (sports medicine, orthopedists, physiatrists and rheumatologists), based on clinical and academic experience in the use of viscosupplementation of the hip. 12 statements were prepared, discussed and voted. Each panelist gave a value between 0 and 10 on a Likert scale, specifying their level of agreement with the statement. Results: The panel reached a consensus on several aspects of viscosupplementation of the hip, with emphasis on the following statements: best indication is for mild to moderate hip arthrosis; it may be indicated in severe osteoarthritis; results may vary according to the characteristics of the viscosupplement used; Viscosupplementation should not be performed as an isolated procedure, but in conjunction with other rehabilitation and pharmacological measures; best injection technique should be based on anatomical references coupled with imaging guidance; it is a cost-effective procedure. Conclusion: Viscosupplementation is a safe and effective therapy for hip osteoarthritis, even in severe cases. Guided injection is recommended. Level of Evidence V, Expert Opinion.

Abstract Aim: This study investigated the Relative Age Effect (RAE) in Brazilian track and field athletes based on sex, age category (U-16, U-18, U-20, U-23 and senior), and event type (sprints/hurdles, middle distance, long-distance, jumps, throws). Methods: Data from 2.259 male and 1.776 female elite track and field athletes, ranked top-50 in events held by the Brazilian Track and Field Confederation in 2019 were analyzed. To determine RAE athletes were divided into four quarters based on their months of birth, considering January 1st the cut-off date. The influence of sex, age category, and event types in the pervasion of RAE in Brazilian track and field athletes was assessed through Chi-squared tests. Results: Athletes born closer to the cut-off date were more frequent than athletes born further from this date were in male youth categories. This effect reduced as categories increased, even reversing in the senior category. Finally, RAE was more frequent in events in which athletic performance relies more on strength, speed, and power, which is the case of sprints/hurdles, jumps, and throws. Conclusion: RAE is particularly prevalent in young male Brazilian track and field athletes, which indicates that many potentially talented athletes are overlooked in youth tryouts because they were born months away from the cut-off date. Policies that reduce the disadvantages faced by relatively younger athletes are warranted in order to avoid the loss of potential sports talents.

Resumo Luxação intra-articular da patela é uma afecção incomum, podendo ocorrer deslocamento no plano horizontal ou vertical; pode se associar com lesão/ruptura do tendão do quadríceps, total ou parcial, com lesão osteocondral ou dos ligamentos colaterais. Fatores de risco são: frouxidão ligamentar, hipermobilidade patelar, patela alta e displasia troclear, e é mais comum em jovens, podendo necessitar de redução cruenta. Casos de luxação intra-articular da patela são eventos raros, sendo necessários uma suspeição diagnóstica e um manejo diferenciado. O objetivo deste trabalho é relatar um caso raro de luxação intra-articular da patela, assim como seu quadro clínico, diagnóstico, conduta e revisão da literatura.

Abstract Intraarticular dislocation of the patella is an uncommon condition, with displacement in the horizontal or vertical plane, which may be associated with total or partial lesion/rupture of the quadriceps tendon, with osteochondral or collateral ligament injury. Risk factors are ligament laxity, patellar hypermobility, high patella, and trochlear dysplasia. This condition is more common in young people and may require blood reduction. Cases of intraarticular dislocation of the patella are rare events, requiring diagnostic suspicion and differentiated management. The aim of the present study is to report a rare case of intraarticular dislocation of the patella, as well as its clinical condition, diagnosis, management and literature review.

Resumo As fraturas da cabeça radial representam mais de 50% de todas as fraturas do antebraço. Broberg e Morrey (modificação da classificação de Mason) as classificam em quatro tipos. As fraturas do tipo 1 são aquelas não deslocadas ou minimamente deslocadas, consideradas estáveis e sem bloqueio mecânico das articulações. Nesse tipo de fratura, um manejo não operatório com um curto período de imobilização permite bom resultado clínico sem desfechos adversos. Lesões associadas clinicamente relevantes não são comuns. Por esse motivo, a artrite da articulação radiocapitelar e ulnoumeral após a fratura da cabeça do rádio não deslocada é incomum. Este relato de caso apresenta um paciente jovem com diagnóstico de fratura isolada da cabeça radial não deslocada que evoluiu, 8 meses depois, para artrite global do cotovelo.

Abstract Fractures of the radial head account for over 50% of all fractures of the forearm. Broberg and Morrey (modification of the Mason classification) classify them in four types. Type 1 fractures are non-displaced or minimally displaced, considered stable and without mechanical joint blockage. In this type of fracture, a non-operative management with a short period of immobilization leads to a good clinical result without adverse outcomes. Clinically relevant associated lesions are not common. Because of this, arthritis of the radiocapitellar and ulnohumeral joint after the non-displaced radial head fracture is uncommon. This case report presents a young patient diagnosed with isolated non-displaced radial head fracture, that evolved 8 months later, to global arthritis of the elbow.

Resumen Este artículo presenta un análisis descriptivo de las prácticas y supuestos adoptados en los informes de valoración de las empresas brasileñas. Las metodologías y los supuestos de los modelos de pronóstico se analizaron utilizando informes de valoración aportados por la Comisión de Valores Mobiliarios de Brasil desde 2004 hasta 2018. Los resultados indican una preferencia por el método de flujo de caja descontado sobre períodos de proyección de entre 5 y 16 años, medidos en moneda nacional sin ajustes por inflación. Las tasas de crecimiento, tanto nominales como reales, no fueron homogéneas debido a las grandes fluctuaciones a lo largo de los años y entre los sectores analizados. Además, las proyecciones de las variables macroeconómicas no resultaron precisas en comparación con los valores económicos reales. También se analizaron las variables utilizadas para determinar los múltiplos presentados en los informes de valoración; los resultados indican que cuanto más elevado sea el riesgo, menor será el múltiplo proyectado y cuanto más elevado el endeudamiento y la tasa de inflación, más elevado será el valor del múltiplo.

Abstract This paper performs a descriptive analysis of the practices and assumptions adopted in the valuation reports of Brazilian companies. The methodologies and assumptions of the forecast models were analysed using valuation reports available from the Brazilian Securities and Exchange Commission between 2004 - 2018. The results indicate a preference for the discounted cash flow methodology over projection periods of between five and sixteen years that are measured in national currency without adjustment for inflation. Growth rates, both nominal and real, were not homogeneous due to large fluctuations over the years and among the sectors analysed. Moreover, the macroeconomic variable projections were not accurate when compared to actual economic values. The variables used to determine multiples presented in valuation reports were also analysed; the results indicate that the higher the risk, the lower the projected multiple, and the higher the indebtedness and the inflation rate, the higher the multiple value.

RESUMO Introdução: Os efeitos osteogênicos gerados pelas diferentes modalidades esportivas são alvo de um crescente número de investigações. A prática regular de atividades físicas é uma das principais recomendações para a estimulação da densidade mineral óssea (DMO). Entretanto, as evidências têm demonstrado que nem todas as atividades físicas promovem efeitos semelhantes. Nesse contexto, os efeitos osteogênicos da natação precisam ser esclarecidos. Objetivo: Verificar e comparar os níveis de DMO, total e regional, entre atletas de natação de ambos os sexos e universitários não atletas. Métodos: A amostra, composta por 60 participantes de ambos os sexos, foi dividida em dois grupos: 30 atletas de natação (GA): 15 homens (22,2±3,92 anos; 73,61±16,55 Kg; 1,76±0,08 m) e 15 mulheres (21,91±2,21 anos; 53,15±8,36 Kg; 1,64±0,06 m) e um grupo controle (GC): 30 universitários não atletas: 15 homens (20,73±1,27anos; 74,4±5,54 Kg; 1,74±0,04 m) e 15 mulheres (19,93±2,05 anos; 59,72±1,33 Kg; 1,63±0,004 m). As DMO (total, dos braços, pernas, pelve e coluna) foram medidas com utilização da absorciometria radiológica de dupla energia (DXA). Os resultados foram comparados com auxílio da ANOVA One-Way utilizando, quando necessário, o teste post hoc de Scheffé. Resultados: Quando comparados com as mulheres, os homens dos dois grupos apresentaram resultados superiores para todas as DMO analisadas. Além disso, o GA apresentou maiores DMO de braços e de coluna quando comparado ao GC, tanto para homens (p=0,016 e p=0,001, respectivamente) quanto para mulheres (p=0,0001 e p=0,011, respectivamente). Conclusão: Os resultados do presente estudo demonstram que os jovens adultos do sexo masculino, atletas e não atletas, apresentam maiores níveis de DMO que seus pares do sexo oposto. Além disso, os resultados sugerem que, quando praticado com objetivo competitivo e com volume de treinamento semanal igual ou superior a 12 horas, a natação pode ser benéfica para o desenvolvimento ósseo de jovens atletas, quando comparado com o grupo controle não atletas. Nível de evidência III; Estudo retrospectivo comparativo.

ABSTRACT Introduction: The osteogenic effects generated by different sports are the subject of a growing number of research projects. Regular physical activity is one of the main recommendations for the stimulation of bone mineral density (BMD). However, evidence has shown that not all physical activities promote similar effects. In this context, the osteogenic effects of swimming need to be clarified. Objective: To verify and compare total and regional BMD levels between male and female swimming athletes and university non-athletes. Methods: The sample, composed of 60 participants of both sexes, was divided into two groups: 30 swimming athletes (GA): 15 men (22.2 ± 3.92 years; 73.61 ± 16.55 kg; 1.76 ± 0.08 m) and 15 women (21.91 ± 2.21 years; 53.15 ± 8.36 kg; 1.64 ± 0.06 m) and a control group (CG): 30 university non-athletes: 15 men (20.73 ± 1.27 years; 74.4 ± 5.54 kg, 1.74 ± 0.04 m) and 15 women (19.93 ± 2.05 years; 59.72 ± 1.33 kg; 1.63 ± 0.004 m). BMD (total, arms, legs, pelvis and spine) was measured using dual energy X-ray absorptiometry (DXA). The results were compared with one-way ANOVA using Scheffé's post hoc test, when necessary. Results: When compared with the women, the men of both groups presented superior results for all BMD values analyzed. In addition, GA had higher BMD of arms and spine when compared to the CG, both for males (p = 0.016 and p = 0.001, respectively) and females (p = 0.0001 and p = 0.011, respectively). Conclusions: The results of this study demonstrate that young male adults, athletes and non-athletes, present higher levels of BMD than their peers of the opposite sex. In addition, the results suggest that when undertaken for competitive purposes and with a weekly training volume of 12 hours or more, swimming may be beneficial for the bone development of young athletes when compared to non-athlete controls. Level of evidence III; Retrospective comparative study.

RESUMEN Introducción: Los efectos osteogénicos generados por las diferentes modalidades deportivas son objeto de un creciente número de investigaciones. La práctica regular de actividades físicas es una de las principales recomendaciones para la estimulación de la densidad mineral ósea (DMO). Entretanto, las evidencias han demostrado que no todas las actividades físicas promueven efectos semejantes. En ese contexto, los efectos osteogénicos de la natación precisan ser esclarecidos. Objetivo: Verificar y comparar los niveles de DMO, total y regional, entre atletas de natación de ambos sexos y universitarios no atletas. Métodos: La muestra, compuesta por 60 participantes de ambos sexos, fue dividida en dos grupos: 30 atletas de natación (GA): 15 hombres (22,2±3,92 años; 73,61±16,55 Kg; 1,76±0,08 m) y 15 mujeres (21,91±2,21 años; 53,15±8,36 Kg; 1,64±0,06 m) y un grupo control (GC): 30 universitarios no atletas: 15 hombres (20,73±1,27 años; 74,4±5,54 Kg; 1,74±0,04 m) y 15 mujeres (19,93±2,05 años; 59,72±1,33 Kg; 1,63±0,004 m). Las DMO (total, de los brazos, piernas, pelvis y columna) fueron medidas con el uso de la absorciometría radiológica de doble energía (DXA). Los resultados fueron comparados con auxilio de ANOVA One-Way utilizando, cuando fuera necesario, el test post hoc de Scheffé. Resultados: Cuando comparados con las mujeres, los hombres de los dos grupos presentaron resultados superiores para todas las DMO analizadas. Además, el GA presentó mayores DMO de brazos y de columna cuando comparado al GC, tanto para hombres (p=0,016 e p=0,001, respectivamente) como para mujeres (p=0,0001 y p=0,011, respectivamente). Conclusión: Los resultados del presente estudio demuestran que los jóvenes adultos del sexo masculino, atletas y no atletas, presentan mayores niveles de DMO que sus pares del sexo opuesto. Además, los resultados sugieren que, cuando practicado con objetivo competitivo y con volumen de entrenamiento semanal igual o superior a 12 horas, la natación puede ser benéfica para el desarrollo óseo de jóvenes atletas, cuando comparado con el grupo control no atletas. Nivel de evidencia III; Estudio retrospectivo comparativo.

Resumo: Apesar dos crescentes esforços para catalogar a diversidade de peixes nos rios amazônicos, muitas regiões ainda estão sub-amostradas e os ambientes de praias arenosas são particularmente pouco compreendidos. Este estudo foi realizado ao longo de um trecho de 300 km do Rio Acre, no sudoeste da bacia amazônica, onde foram amostradas 30 praias, separadas por uma distância média de 10 km. Foram coletados 15.329 peixes, representados em 80 espécies, 26 famílias e nove ordens. Characiformes foi a ordem mais abundante, representando 88,24% dos indivíduos coletados, seguidos pelos Siluriformes, com 10,03%, enquanto os Siluriformes apresentaram a maior riqueza, com 37 espécies (45,0%), seguidas pelos Characiformes, com 30 espécies (37,5%). As espécies mais abundantes foram os characiformes Knodus orteguasae e Creagruto barrigai. Dados confiáveis sobre a biota de uma região são fundamentais para a avaliação dos padrões de biodiversidade e conhecimento sobre a ocorrência e manejo de espécies ameaçadas. Como os peixes são diretamente afetados por poluentes e pela degradação dos ambientes aquáticos, mais pesquisas em áreas que ainda são pouco amostradas serão essenciais para a elaboração de estratégias eficazes de conservação.

Abstract: Despite increasing efforts in recent years to catalog the fish diversity of Amazonian rivers, many regions are still under-sampled, and sandy beach environments are particularly poorly understood. The present study focused on a 300 km stretch of the Acre river, in the southwestern Amazon basin, where we sampled 30 sandy beaches separated by a mean interval of 10 km. We collected 15,329 fish representing 80 species, 26 families, and nine orders. The Characiformes were the most abundant order, providing 88.24% of the individuals collected, followed by the Siluriformes, with 10.03%, while the Siluriformes had the highest species richness, with 37 species (45.0%), followed by the Characiformes, with 30 (37.5%). The most abundant species were the characiforms Knodus orteguasae and Creagruto barrigai. Reliable data on a region’s biota is fundamental for the evaluation of patterns of biodiversity, and the occurrence and management of threatened species. As fish are directly affected by pollutants and the degradation of aquatic environments, further research in areas that are still poorly sampled will be essential for the elaboration of effective conservation strategies.

ABSTRACT New techniques for manufacturing of biomaterials using additive/substrate manufacturing such as melting laser sintering (SLM) or CAD/CAM milling use micrometric metal powders to build custom parts. CoCrMo alloys are commonly used as biomaterials due to biocompatibility, high corrosion resistance and good mechanical properties. In this work, Cr-Co-based powder was obtained by mechanical alloying of Cr-Co-Mo-W alloy, using different Ball/Powder-Ratios (BPR) and thermal treatments. The powders were deagglomerated and characterized by X-ray diffraction (XRD) and Scanning electron microscopy (SEM). Based on SEM micrographs, the particle size analysis was used to compare the particles spheroidizing degree, using Feret’s diameter. The XRD patterns shown Co(solid-solution) as crystalline phase. The results of particles size indicates a decrease of Feret’s diameter in BPR (Ball/Powder-Ratio) from 4:1 to 6:1 understanding that from this ratio there is no significant decrease of this relation but there is an average size increase with losses in morphological aspect. The comparison between atomized powders and powder developed in this work indicates that atomized products present relation close to one which indicates there is uniformity in the particles spherical shape. Comparing ground powders from 6:1 ratio (before and after thermal treatment) there is a considerable decrease of Feret’s diameter being it decreased from 1.75 to 1.4, an increase of about 46% in particles spheroidizing.

Resumo Os piolhos marinhos são copépodes abrangentemente relatados em teleósteos marinhos ao redor do mundo. Neste estudo, é documentado o primeiro registro de Caligus asperimanus Pearse, 1951, no Atlântico Sul Ocidental, parasitando Lutjanus jocu e Lutjanus vivanus capturados nas zonas costeiras do Espírito Santo e Rio de Janeiro, respectivamente.

Abstract Sea lice are widespread copepods in marine teleost around the world. In this paper the first record of Caligus asperimanus Pearse, 1951 in the Western South Atlantic is documented parasitizing Lutjanus jocu and Lutjanus vivanus caught from coastal zones of Espírito Santo and Rio de Janeiro State, respectively.

Abstract We present here the genome sequence of Shewanella corallii strain A687 isolated from pufferfish Sphoeroides spengleri (Family Tetraodontidae). The assembly consists of 5,215,037 bp and contains 284 contigs, with a G+C content of 50.3%.

Abstract Negative changes in cardiovascular and autonomic variables in stroke survivors have encouraged the global scientific community to focus on investigating therapeutic strategies to mitigate stroke damage. The objective of the present study was to describe the effects of exercise training on cardiovascular and autonomic variables in stroke survivors. We used the PICO (population, intervention, control/comparison, and outcome variables) model for the search of articles in PubMed and Physiotherapy Evidence Databases from 2009 to December 2018. The following data were also recorded: type of study, author, year of publication, participants (time after stroke, sample size, and age) and benefits of exercise training. A total of 544 articles were initially selected, of which nine peer-reviewed articles met the search criteria. These nine studies enrolled 611 participants (middle-aged or elderly), and pointed to positive effects of training on maximal oxygen uptake, peak aerobic capacity, 6-minute walk test and resting heart rate. However, more well-controlled studies are needed to confirm the benefits of exercise training on cardiovascular and autonomic variables in this population.

RESUMO Objetivo: O Consenso Brasileiro de Viscossuplementação visa gerar uma fonte referencial e consensual, a partir de levantamentos bibliográficos relevantes, do conhecimento teórico e da experiência clínica de especialistas de áreas afins para tratamento de viscossuplementação na osteoartrite do joelho, mitigando pontos críticos desse procedimento, como via de aplicação, indicação, eficácia e tolerabilidade. Métodos: Um painel multidisciplinar foi formado com dois médicos do esporte, seis ortopedistas, quatro fisiatras e dois reumatologistas, com base nas experiências clínica e acadêmica no uso da viscossuplementação. Foram elaboradas, discutidas e votadas 16 afirmativas. Cada membro do painel deu um valor entre zero e 10, em uma escala tipo Likert, especificando seu nível de concordância com a afirmação. Resultados: O painel chegou a um consenso sobre diversos aspectos da viscossuplementação, com destaque para as seguintes afirmativas: a melhor indicação é para artrose de joelhos leve a moderada; o uso prévio ou concomitante de hexacetonido de triancinolona intra-articular pode otimizar o efeito do ácido hialurônico; a viscossuplementação não deve ser realizada como procedimento isolado no tratamento da OA, mas em conjunto com outras medidas reabilitadoras e farmacológicas; promove efeito analgésico; anti-inflamatório; condroprotetor; e é custo-efetiva. Conclusão: Este consenso traz informações claras e servirá, como guia tanto para médicos quanto para as fontes pagadoras. Nível de evidência V, Consenso de especialistas.

ABSTRACT Objective: The aim of this consensus statement on viscosupplementation is to serve as a reference document based on relevant literature and clinical experience in the treatment of knee osteoarthritis using an intra-articular injection of hyaluronic acid, covering key aspects such as clinical indications, effectiveness, and tolerability. Methods: A multidisciplinary panel including two sports medicine physicians, six orthopedists, four physiatrists, and two rheumatologists were selected based on their clinical and academic experience of viscosupplementation. Sixteen statements were prepared and discussed, after which a vote was held. Each member of the panel gave a score between 0 and 10 on a Likert scale, specifying their level of agreement with the statement. Results: The panel reached a consensus on several issues. Specifically, the panel agreed that the best indication is for mild to moderate knee arthrosis; prior or concomitant use of intraarticular triamcinolone hexacetonide may optimize the effect of hyaluronic acid; viscosupplementation should not be performed as an isolated procedure but in conjunction with other rehabilitative and pharmacological measures; viscosupplementation has analgesic, anti-inflammatory, and chondroprotective effects; and viscosupplementation is cost-effective. Conclusion: This consensus statement provides clear information and guidance for both individuals and payers. Level of evidence V, Consensus statement.