RESUMO Contexto: O papel dos alimentos lácteos na doença inflamatória intestinal (DII) tem sido controverso e é discutível se os pacientes com DII devem ou não evitar leite e laticínios, bem como a relação entre esses alimentos e sintomas nesta população. Objetivo: Estudo transversal multicêntrico foi projetado para avaliar se é realmente necessário privar os pacientes com DII do consumo desta classe de alimentos. Métodos: Um estudo multicêntrico com 12 centros de referência em gastroenterologia de quatro países foi projetado para avaliar sintomas gastrointestinais após o consumo de alimentos lácteos em todos os ambulatórios de DII durante seis meses e comparar pacientes tratados nos mesmos centros sem DII. Resultados: No total, foram incluídos 1888 casos (872 pacientes com DII e 1016 casos sem DII. 56,6% dos participantes eram do sexo feminino com idade média de 40,1 anos. 79,8% dos participantes eram caucasianos e originalmente eram cidadãos de 10 países. A prevalência relativa de DII foi maior em africanos e indianos e a prevalência mais frequente de intolerância a alimentos lácteos observada nos asiáticos. Entre os pacientes com DII, 571 casos foram diagnosticados como colite ulcerativa e 189 participantes como doença de Crohn. A duração média do diagnóstico como DII foi de 6,8 anos (de 2 meses a 35 anos). Os sintomas de gastrointestinais mais prevalentes após o consumo de todos os alimentos lácteos foram inchaço e dor abdominal. No total, a intolerância aos alimentos lácteos e a deficiência de lactase foi mais prevalente entre os pacientes com DII em comparação com os casos sem DII (65,5% vs 46,1%, P=0,0001). A taxa de queixas gastrointestinais entre os pacientes com DII que não tinham histórico familiar de deficiência de lactase, histórico de sensibilidade alimentar ou ambos foram de 59,91%, 52,87% e 50,33% respectivamente e semelhantes aos casos sem DII (P=0,68, 0,98 e 0,99, respectivamente). Conclusão: A taxa de intolerância de alimentos lácteos entre pacientes com DII sem histórico familiar de deficiência de lactase ou histórico de sensibilidade alimentar é semelhante aos casos sem DII e provavelmente não há razão para privá-los dessa importante fonte de cálcio dietético, vitamina D e outros nutrientes.

ABSTRACT Background: The role of dairy foods in inflammatory bowel disease (IBD) has been controversial and it is debatable if patients with IBD should avoid milk and dairy products or not, as well as the relationship between these foods and symptoms among those population. Objective: This multi centric cross-sectional study designed to evaluate if it is really necessary to deprive IBD patients from consumption of dairy foods. Methods: A multicenter study with 12 gastroenterology referral centers in four countries was designed to evaluate gastrointestinal (GI) symptoms after consumption of dairy foods from all outpatients with IBD during 6 months and to compare patients treated at the same centers without IBD (non IBD cases). Results: Overall 1888 cases included (872 IBD patients and 1016 non IBD cases). 56.6% of participants were female with average age of 40.1 years. Racially 79.8% participants were Caucasians and originally they were citizens of 10 countries. Relative prevalence of IBD was higher in Africans and Indians and the most frequent prevalence of dairy foods intolerance was seen in Asians. Among IBD patients, 571 cases diagnosed as ulcerative colitis and 189 participants as Crohn’s disease. Average duration of diagnosis as IBD was 6.8 years (from 2 months to 35 years). The most prevalent GI symptoms after consumption of all the dairy foods were bloating and abdominal pain. Totally, intolerance of dairy foods and lactase deficiency was more prevalent among IBD patients in comparison with non IBD cases (65.5% vs 46.1%, P=0.0001). But the rate of GI complains among IBD patients who had not any family history of lactase deficiency, history of food sensitivity or both were 59.91%, 52.87% & 50.33% respectively and similar to non IBD cases (P=0.68, 0.98 & 0.99 respectively). Conclusion: The rate of dairy foods intolerance among IBD patients without family history of lactase deficiency or history of food sensitivity is similar to non IBD cases and probably there is no reason to deprive them from this important source of dietary calcium, vitamin D and other nutrients.

Abstract: The aim of this research was to investigate the effects of longitudinal position (stem height) and heart-sapwood on density, modulus of elasticity (MOE) and modulus of rupture (MOR) in bending for Persian silk wood (Albizzia julibrissin). Five normal trees were selected from the Guilan region, Iran. Samples for testing were prepared at four stem height levels (5%, 25%, 50% and 75% of total stem height) in both positions along radial direction (heartwood and sapwood). Analysis of variance results (Anova) indicated that the effects of longitudinal position (stem height) and heartwood-sapwood on the wood density, MOE and MOR were significant. The mean of wood density, MOE and MOR along longitudinal position from base to top decreased with height. The mean of wood density, MOR and MOE in sapwood are lower compared to the corresponding values for heartwood. The relationship between wood density and mechanical strength properties were analyzed by regression models. A positive correlation was found between wood density with MOE and MOR in both heartwood and sapwood.

Resumen: El objeto de esta onvestigación fue estudiar los efectos de la posición en dirección longitudinal (altura del tronco) y del duramen y la albura sobre la densidad, el módulo de elasticidad (MOE) y el módulo de ruptura (MOR) en flexión para la madera de 'seda' persa (Albizzia julibrissin). Se recolectaron cinco árboles representativos de la región de Guilan, Irán. Se elaboraron especímenes para prueba a cuatro niveles de la altura del árbol (5%, 25%, 50% y 75% de la altura total del tronco) en ambos tipos de madera en la dirección radial (duramen y albura). Los resultados de los análisis de varianza (Andeva) indicaron que los efectos de la ubicación longitudinal (altura del árbol) y duramen y albura sobre la densidad de la madera, el MOE y el MOR fueron significativos. Los valores promedio de la densidad, MOE y MOR a lo largo de la posición longitudinal de la base a la copa disminuyeron con la altura. Los valores promedio de la densidad, MOR y MOE en albura son menores comparados con los del duramen. La relación entre la densidad de la madera y las propiedades mecánicas se analizaron por medio de modelos de regresión. Se encontró una correlación positive entre la densidad de la madera con MOE y MOR tanto en duramen como en albura.

Persian Ironwood (Parrotia persica (DC) CA Meyer) is native species from Iran and covers 10,54% of the commercial volume. Its wood structure and its chemical composition are affected by growth conditions. The aim of the study was to assess the variation of mineral content (Ni, Fe, Cu, Zn, Pb, Cd), wood density and chemical properties (cellulose, lignin, ash and extractive) of ironwood in relation to altitude above sea level (100, 500 and 700 meter) and pith distance within stem (near to pith and bark and middle point). In addition was investigate the relationship between mineral content with oven-dried density and chemical properties. Results showed that Cd, Cu, Fe, Ni and Zn content (except Pb concentration) increased by increasing of altitude and decreased along radial position within stem from the pith to the bark. Lignin, ash and extractive content increased by increasing altitudes from 100 to 700 meter while cellulose decreased. Radial position had not significant impact on the chemical properties. There are significant relationships between mineral content-chemical properties and between mineral content-wood density (except Cu - density). Forward stepwise regression showed that ash and lignin content had important role on the variation of all of mineral content except on Cd.

Objetivo: O objetivo deste estudo foi analisar o papel da suplementação com ácidos graxos ômega-3 sobre a concentração de ácidos graxos não esterificados (AGNE), resistência e sensibilidade à insulina e metabolismo de lipídios em pacientes com diabetes melito tipo 2. Sujeitos e métodos: Quarenta e quatro pacientes com diabetes tipo 2 foram recrutados aleatoriamente e alocados em um de dois grupos. O Grupo A recebeu 4 g/dia de ômega-3 na forma de cápsulas gelatinosas e o grupo B recebeu placebo durante 10 semanas. Amostras de sangue foram coletadas após 12 horas de jejum. Registros da atividade física, da dieta de três dias e medidas antropométricas foram obtidos de todos os participantes no início e no final do estudo. Resultados: A suplementação com ômega-3 causou uma redução significativa na AGNE em comparação com grupo placebo (P = 0,008). Além disso, a administração de ômega-3 resultou em alterações significativamente maiores (Dif) em vários parâmetros, tais como a insulina, HOMA-IR e QUICKI, comparando com placebo (P < 0,05). Conclusões: A suplementação com ácidos graxos ômega-3 em pacientes diabéticos tipo 2 melhorou a sensibilidade à insulina, provavelmente devido à diminuição da concentração de AGNE. Arq Bras Endocrinol Metab. 2014;58(4):335-40

Objective: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Subjects and methods: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. Results: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). Conclusions: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations. Arq Bras Endocrinol Metab. 2014;58(4):335-40

Recently, the Smoothed Particle Hydrodynamics (SPH) method has been utilized as an effective tool for capturing details of the fluid flows. The Lagrangian nature of the SPH method facilitates the modeling of the free surface flows. In the present article, different numerical features of 3D-SPH are probed to find a set of options that can be used to achieve an accurate numerical simulation of the dam break problem. Several numerical techniques such as time stepping algorithm, filter density and viscosity treatment are considered as compiling options. Twelve sets of mentioned schemes are also chosen and the elevation of free surface flow is captured. The obtained results are compared against the experimental data existing in the literature. Finally, it is concluded that the Symplectic algorithm in conjunction with density filter and SPS turbulence model can be used to achieve the desired accurate numerical results.

Mentha piperita (Labiatae), commonly known as peppermint is a native Iranian herb which is used in folk medicine for various purposes. This study was carried out to reveal the teratogenic effect of Mentha piperita on mice fetuses. In this experimental study, pregnant Balb/c mice divided to four groups. Case group received 600 (treatment I) and 1200 (treatment II) mg/kg/day the hydroalcoholic extract of Mentha piperita during 6-15 of gestational days and one control group received normal saline during GD6-GD15 by gavages and other control group did not receive any matter during 6-15 of gestational days. Mice sacrificed at GD18 and embryos were collected. Macroscopic observation was done by stereomicroscope. 20 fetuses of each group were stained by Alizarin red-S and Alcian blue staining method. The Mean weight of fetuses decreased in treatment groups rather than control (P<0.05) but CRL there was no significant difference between treatments and controls groups. In the treatment I (600 mg/kg/day) and treatment II (1200 mg/kg/day), normal saline and control group, no gross congenital malformations were observed in fetuses. Treated fetuses also had no delayed bone ossification as determined by Alizarin red-S and Alcian blue staining method. This study showed that the hydroalcoholic extract of Mentha piperita (600 and 1200 mg/kg/day) has no teratogenic effect in mice fetuses if used continuously during embryonic period.

Mentha piperita (Labiatae), comúnmente conocida como menta, es una hierba nativa de Irán, que se utiliza en la medicina tradicional para diversos fines. Este estudio fue realizado para descubrir el efecto teratogénico de la Mentha piperita en fetos de ratones. Los ratones Balb/c preñadas fueron divididas en cuatro grupos. Los grupos recibieron 600 (tratamiento I) y 1200 (tratamiento II) mg/kg/día del extracto hidroalcohólico de Mentha piperita durante los días 6-15 de gestación (DG), mientras que un grupo control recibió solución salina normal durante los DG 6-15 vía oral y otro grupo control sano no recibió substancia durante los DG 6-15. Los ratones fueron sacrificados el DG 18, recolectando los fetos. Se realizó la observación macroscópica mediante un estereomicroscopio. 20 fetos de cada grupo se tiñeron por el método de rojo de alizarina-S y azul de Alcián. La media de peso de los fetos disminuyó más en los grupos de tratamientos que los controles (p <0,05), pero CRL no presentó diferencias significativas entre los tratamientos y los grupos control. En los fetos del grupos tratamiento I (600 mg/kg/día), tratamiento II (1200 mg/kg/día), solución salina normal y control no se observó ninguna malformación congénita grave. Los fetos tratados tampoco tuvieron osificación ósea retrasada según lo determinado por el método de rojo de alizarina-S y azul de Alcián. Este estudio mostró que el extracto hidroalcohólico de Mentha piperita (600 y 1200 mg/kg/día) no tiene efectos teratogénicos en fetos de ratones al ser utilizado continuamente durante el período embrionario.

Sheet metal bending is one of the most widely applied sheet metal operations. The bending operations present several technical problems in production, such as prediction of spring-back and the punch load. In this paper, the value of the spring-back and bending forces are investigated for a low carbon steel material. Two thicknesses of material (0.95 and 0.75 mm) are applied. Sheet metal components, which are used in the experiments, have oblong holes on their bending surfaces. The influence of the area of the holes, die angles, die widths and punch radius on the value of the spring-back and the bending forces in V-die bending is studied. It is found that all these parameters affect the spring-back and the bending forces, but not in the same way. A new equation is suggested in this paper to predict the bending forces in V-shaped dies for parts with holes on the bending surfaces.

Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze after hematoxylin and eosin staining. All data are shown as means plus standard errors of means and were analyzed using One-Way ANOVA test at P<0.05.The mean area of hepatocytes, nuclei and nucleolus had a decrease in periportal zone and an increase in perivenous zone in the diabetic and treatment groups. The increase of hepatocyte area in perivenous zone and reduce of nucleus area in periportal zone was significant in the diabetic group in comparison with control group (P<0.05), but were not significant between treatment and diabetic group. This study showed that administration of 100 mg/kg/day of Urtica dioica leaves extracts after induction of diabetes can cause a little modulating in the main morphometric indices of liver such as area of hepatocytes, nuclei and nucleolus in periportal and perivenous zones.

La diabetes esta asociada con severas anormalidades en la estructura y funcionamiento del hígado que afectan el metabolismo glicogénico y lipídico. En el presente estudio, se evaluó los efectos del extracto hidroalcohólico de Urtica dioica, observando los cambios morfométricos cuantitativos en las células del parénquima hepático de ratas diabéticas STZ. Se utilizaron 30 ratas Wistar, machos, conformando 3 grupos: normal, diabéticas y con tratamiento. Se indujo una hiperglicemia injectando intraperitonealmente con 80 mg/kg de estreptozotocina. Una semana después de la inyección de STZ, el tercer grupo recibió el extracto hidroalcohólico de Urtica dioica en dosis de 100mg/kg/día por 4 semanas. Después de 5 semanas, los animales fueron sacrificados y sus hígados removidos.Las muestras de hígado fueron usadas para análisis morfométrico cuantitativo y posteriormente teñidos con hematoxilina eosina. Los datos son mostrados como promedios con sus respectivas desviaciones Standard y fueron analizados con un test de ANOVA con un p menor a 0,05. El área promedio de los hepatocitos, núcleos y nucléolos tuvieron una disminución en la zona periportal y un incremento en la zona perivenosa en los grupos diabético y con tratamiento. El incremento del área del hepatocito en la zona perivenosa y la reducción del área nuclear en la zona periportal fue significativa en el grupo diabético en comparación con el grupo control (p menor que 0,05), pero no fue significativo entre las ratas tratadas y el grupo diabético. Este estudio mostró que la administración de 100 mg/kg/día de extracto de Urtica dioica después de la inducción de diabetes puede causar una pequeña modulación en los índices morfométricos principales del hígado, tales como: área de los hepatocitos, núcleos y nucléolos en las zonas periportal y perivascular.