Pesquisa | SciELO

ABSTRACT BACKGROUND: The effect of weight loss (WL) on histopathological aspects of non-alcoholic fatty liver disease (NAFLD) may provide further insights into the dynamics of hepatic recovery after WL. OBJECTIVE: To analyze the effects of pre-operative WL on insulin resistance- and NAFLD-related histology in individuals undergoing bariatric surgery (BS) with or without pre-operative WL. DESIGN AND SETTING: A matched cross-sectional study was conducted at a public university hospital and a private clinic in Campinas, Brazil. METHODS: An analytical, observational, cross-sectional study was conducted using prospectively collected databases of individuals who underwent BS and liver biopsy at either a public tertiary university hospital (with pre-operative WL) or a private clinic (without pre-operative WL). Random electronic matching by gender, age, and body mass index (BMI) was performed and two paired groups of 24 individuals each were selected. RESULTS: Of the 48 participants, 75% were female. The mean age was 37.4 ± 9.6. The mean BMI was 38.9 ± 2.6 kg/m2. Fibrosis was the most common histopathological abnormality (91.7%). Glucose was significantly lower in the WL group (92 ± 19.1 versus 111.8 ± 35.4 mg/dL; P = 0.02). Significantly lower frequencies of macrovesicular steatosis (58.3% versus 95.8%; P = 0.004), microvesicular steatosis (12.5% versus 87.5%; P < 0.001), and portal inflammation (50% versus 87.5%; P = 0.011) were observed in the WL group. CONCLUSION: Pre-operative WL was significantly associated with lower frequencies of macro- and mi- crovesicular steatosis, portal inflammation, and lower glycemia, indicating an association between the recent trajectory of body weight and histological aspects of NAFLD.

https://doi.org/10.1590/1516-3180.2022.0663.r1.24042023

Brazilian Society of Otology task force - Otosclerosis: evaluation and treatment
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Silva, Vagner Antonio Rodrigues

; Pauna, Henrique Furlan

; Lavinsky, Joel

; Guimarães, Guilherme Corrêa

; Abrahão, Nicolau Moreira

; Massuda, Eduardo Tanaka

; Vianna, Melissa Ferreira

; Yudi Ikino, Cláudio Márcio

; Santos, Vanessa Mazanek

; Polanski, José Fernando

; Silva, Maurício Noschang Lopes da

; Sampaio, André Luiz Lopes

; Zanini, Raul Vitor Rossi

; Lourençone, Luiz Fernando Manzoni

; Denaro, Mariana Moreira de Castro

; Calil, Daniela Bortoloti

; Chone, Carlos Takahiro

; Castilho, Arthur Menino

Brazilian Journal of Otorhinolaryngology

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Out 2023, Volume 89 Nº 5 elocation 101303

Resumo: En | Texto: En | PDF: En

Abstract Objectives: To review and provide evidence-based recommendations for the diagnosis and treatment of otosclerosis. Methods: Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on otosclerosis were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions. Results: The topics were divided into 2 parts: 1) Diagnosis – audiologic and radiologic; 2) Treatment – hearing AIDS, pharmacological therapy, stapes surgery, and implantable devices - bone-anchored devices, active middle ear implants, and Cochlear Implants (CI). Conclusions: The pathophysiology of otosclerosis has not yet been fully elucidated, but environmental factors and unidentified genes are likely to play a significant role in it. Women with otosclerosis are not at increased risk of worsening clinical condition due to the use of contraceptives or during pregnancy. Drug treatment has shown little benefit. If the patient does not want to undergo stapedotomy, the use of hearing aids is well indicated. Implantable systems should be indicated only in rare cases, and the CI should be indicated in cases of profound deafness.

https://doi.org/10.1016/j.bjorl.2023.101303

Type of delivery and pain response in full-term newborns after vitamin K administration: assessment using the COMFORT Behavior and Neonatal Facial Coding System scales fullterm full term administration
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Ferreira, Esther Angelica Luiz

; Valete, Cristina Ortiz Sobrinho

; Nassif, Damaris Souza

; de Barros, Guilherme Antonio Moreira

Brazilian Journal of Anesthesiology

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Abr 2023, Volume 73 Nº 2 Páginas 232 - 233

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1016/j.bjane.2022.10.005

Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples
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Ferreira-Nunes, Ricardo

; Almeida, Edson Aliel Teixeira de

; Cunha-Filho, Marcilio

; Gratieri, Tais

; Gelfuso, Guilherme Martins

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e21626

Resumo: En | Texto: En | PDF: En

Abstract In our study, we aimed to validate a method based on liquid chromatography-mass spectrometry (LC-MS) to quantify spironolactone (SPI) and its active metabolite canrenone (CAN) simultaneously in plasma samples to support in vivo experiments. Compounds were separated by using a C18 column with the isocratic elution of a mobile phase composed of 0.1% (v/v) formic acid in methanol-water (60:40 v/v) at a flow rate of 0.4 mL min−1. SPI and CAN were detected in na electrospray interface operating in a positive ionization mode and quantified using the selective ion mode monitoring of mass-charge ratios (m/z) of 439.0 for SPI and 363.1 for CAN. After calculating the matrix effect using theoretical equations, we observed the strong interference of plasma in the equipment-generated signal, which required creating analytical curves using the matrix as a solvent. The method was nevertheless linear (r 2 > 0.999) in a concentration range of 0.4-5.0 μg mL−1, as well as precise, with a coefficient of variation less than 5%. SPI’s and CAN’s recovery rates from the plasma ranged from 87.4% to 112.1%, while their limits of detection (i.e., 0.07 μg mL−1 and 0.03 μg mL−1, respectively) and quantification (i.e., 0.20 μg mL−1 and 0.08 μg mL−1, respectively) in the presence of plasma contaminants were low. Therefore, the bioanalytical method seems to be feasible for quantifying SPI and CAN in plasma.

https://doi.org/10.1590/s2175-97902023e21626

Design, Prototyping and Stratospheric Launch of CubeSats for University Competition
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Coutinho, Diego Anestor

; Paulino, Pedro Lucas Siqueira

; Conceição, Arielli Ajudarte da

; Vilela, Sthefany Farias

; Aquino, Guilherme Pedro

; Ferreira Junior, Antonio Alves

; Boas, Evandro César Vilas

Journal of Aerospace Technology and Management

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2023, Volume 15 elocation e0623

Resumo: En | Texto: En | PDF: En

ABSTRACT This work presents the design and prototyping of two 1U standard CubeSats for the First Brazilian MCTI Satellite Olympiad, launching one in a stratospheric helium-filled balloon. The nanosatellites were designed for two missions: Internet of Things connectivity in remote areas based on CubeSat (IoSat) and low-orbit harmful gamma radiation mapping (LOHGRM). The IoSat mission aimed to provide server connectivity for a remote sensor network. The LOHGRM CubeSat was designed for sensing and mapping gamma radiation power levels in the satellite’s orbit to construct a heat map to study the gamma radiation effect on the equipment. The prototype’s performance was evaluated based on physical, mechanical, magnetic, thermal, and transmission characterization, with satisfactory results under test conditions. The LOHGRM mission test was carried out on the ground as proof of concept without flying while a stratospheric balloon launched the IoSat prototype. Due to restrictions imposed by the competition, the IoSat nanosatellite only captured and registered altitude, pressure, and temperature data without testing the communication payload. Instead, this data was sent to the ground station through the competition communication system and stored in a memory card to assess its operation during the flying. The satellite’s maximum altitude was 22.6 km, operating under –23.5 °C.

https://doi.org/10.1590/jatm.v15.1295

Stroke Is Associated with Refractory Hypertension among Resistant and Refractory Patients in a Cross-Sectional Study
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Costa, Guilherme de Andrade

; Oliveira Filho, Jamary

; Ferreira-Campos, Luana

; Improta-Caria, Alex Cleber

; Macedo, Cristiano

; Sarno Filho, Marcelo Vincenzo

; Borges, Leonardo Silva Roever

; Aras Júnior, Roque

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20220175

Resumo: En | Texto: En | PDF: En

Abstract Background Refractory hypertension (RfH) is a severe phenotype of resistant hypertension (RH) linked to higher risk of stroke and other adverse cardiovascular events, but knowledge about it is still lacking. Objectives To evaluate the association between RfH and stroke. Methods We conducted a cross-sectional study in a referral clinic for patients with severe hypertension in the period from 2018 to 2020. RH was defined as uncontrolled blood pressure (BP) despite the use of 3 antihypertensive agents, including a diuretic, or the use of ≥ 4 agents regardless of BP control. RfH was defined as lack of BP control despite use of ≥ 5 antihypertensive agents. Individuals were classified as RfH or RH, and multivariate logistic regression models were constructed to examine the association between RfH and stroke. Results We evaluated a total of 137 patients; 81% were female, and 93,3% were Black or multiracial. The mean age was 64.4 years. Stroke was more prevalent in the RfH group (35.7%), in comparison to the RH group (12.8%) (p value = 0.01). Unadjusted odds ratio (OR) and 95% confidence interval (CI) for factors associated with stroke were RfH (OR 3.77; 95% CI 1.45 to 9.80), systolic BP (OR 1.02; 95% CI 1.002 to 1.04) and diastolic BP (OR 1.03; 95% CI 1.001 to 1.06). Adjusted OR for factors associated with stroke were RfH (OR 3.55; 95% CI 1.02 to 12.42), systolic BP (OR 1.02; 95% CI 0.99 to 1.05) and diastolic BP (OR 1.01; 95% CI 0.96 to 1.06). Conclusion RfH was associated with higher prevalence of stroke. Efforts are required to better understand this association to prevent adverse cardiovascular outcomes in these patients.

https://doi.org/10.36660/ijcs.20220175

Electromagnetic Behavior of Cu and Ni Nanofilms in the X-band
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Gonçalves, Vitor Fernando de Melo

; Anjos, Erick Gabriel Ribeiro dos

; Morgado, Guilherme Ferreira de Melo

; Brazil, Tayra Rodrigues

; Baldan, Maurício Ribeiro

; Souza, Maria Aparecida Miranda de

; Nohara, Evandro Luís

; Rezende, Mirabel Cerqueira

Journal of Aerospace Technology and Management

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2023, Volume 15 elocation e1223

Resumo: En | Texto: En | PDF: En

ABSTRACT Currently, the presence of spurious microwave radiation is increasing in the environment, which has caused concern due to possible health problems in living beings and electromagnetic interference in electronic systems. To control this problem, studies in the materials area are taking place, aiming to attenuate the spurious radiation and meet requirements of good performance in broadband, low cost and low weight. The present work aimed to study Cu and Ni nanometric films with thicknesses of 65 and 200 nm, deposited on polyethylene terephthalate substrate by magnetron sputtering. Scanning electron microscopy with a field emission gun (FEG-SEM) showed that the films produced have different morphological textures, due to the parameters used in the sputtering process and also the free energy of metals. Impedance spectroscopy measurements showed that the films have low conductivity values, due to the metallic oxides formed on the film surfaces, confirmed by X-ray diffraction, and also to the presence of defects. Electromagnetic characterization (8.2 – 12.4 GHz) showed that the Cu and Ni thin films had low performance, except the Ni_200 nm film, which showed a total shielding efficiency of about 30% in broadband. This result is promising considering the nanometric thickness of the Ni film.

https://doi.org/10.1590/jatm.v15.1301

Risk factors for death and illness severity in vaccinated versus unvaccinated COVID-2019 inpatients: a retrospective cohort study
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Costa, Guilherme Jorge

; Silva Junior, José Roberto da

; Silva, Caio Cesar Arruda da

; Lima, Tiago Pessoa Ferreira de

; Costa, Mariana Menezes

; Sousa, Marcos Henrique Oliveira

; Costa, Gabriela Carla dos Santos

; Costa Júnior, José Iran

; Sales, Mozart Júlio Tabosa

Jornal Brasileiro de Pneumologia

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2023, Volume 49 Nº 4 elocation e20230145

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To determine the clinical profile of COVID-19 inpatients who were vaccinated prior to hospitalization and to compare the risk factors for death and the 28-day survival rate of between those inpatients vaccinated with one, two, or three doses and unvaccinated COVID-19 inpatients. Methods: This was a retrospective observational cohort study involving COVID-19 patients admitted to a referral hospital in the city of Recife, Brazil, between July of 2020 and June of 2022. Results: The sample comprised 1,921 inpatients, 996 of whom (50.8%) were vaccinated prior to hospitalization. After adjusting the mortality risk for vaccinated patients, those undergoing invasive mechanical ventilation (IMV) had the highest mortality risk (adjusted OR [aOR] = 7.4; 95% CI, 3.8-14.1; p < 0.001), followed by patients > 80 years of age (aOR = 7.3; 95% CI, 3.4-15.4; p < 0.001), and those needing vasopressors (aOR = 5.6; 95% CI, 2.9-10.9; p < 0.001). After adjusting the mortality risk for all patients, having received three vaccine doses (aOR = 0.06; 95% CI, 0.03-0.11; p < 0.001) was the most important protective factor against death. There were progressive benefits of vaccination, reducing the frequency of ICU admissions, use for IMV, and death (respectively, from 44.9%, 39.0% and 39.9% after the first dose to 16.7%, 6.2% and 4.4% after the third dose), as well as significant improvements in survival after each subsequent dose (p < 0.001). Conclusions: Vaccines were effective in reducing illness severity and death in this cohort of COVID-19 inpatients, and the administration of additional doses conferred them with accumulative vaccine protection.

RESUMO Objetivo: Traçar o perfil clínico de pacientes internados com COVID-19 que haviam sido vacinados antes da hospitalização e comparar os fatores de risco para óbito e a taxa de sobrevida em 28 dias entre esses internados vacinados com uma, duas ou três doses e pacientes internados com COVID-19 não vacinados. Métodos: Estudo de coorte observacional retrospectivo envolvendo pacientes com COVID-19 internados em um hospital de referência na cidade do Recife (PE) entre julho de 2020 e junho de 2022. Resultados: A amostra foi composta por 1.921 pacientes internados, dos quais 996 (50,8%) haviam sido vacinados antes da hospitalização. Após ajuste do risco de mortalidade para os pacientes vacinados, aqueles submetidos à ventilação mecânica invasiva (VMI) apresentaram o maior risco de mortalidade (OR ajustada [ORa] = 7,4; IC95%: 3,8-14,1; p < 0,001), seguidos pelos pacientes > 80 anos (ORa = 7,3; IC95%: 3,4-15,4; p < 0,001) e aqueles que necessitam de vasopressores (ORa = 5,6; IC95%: 2,9-10,9; p < 0,001). Após ajuste do risco de mortalidade para todos os pacientes, o recebimento de três doses de vacina (ORa = 0,06; IC95%: 0,03-0,11; p < 0,001) foi o fator de proteção mais importante contra o óbito. Houve benefícios progressivos da vacinação, com redução da frequência de internações em UTI, de uso de VMI e de óbitos (de 44,9%, 39,0% e 39,9% após a primeira dose para 16,7%, 6,2% e 4,4% após a terceira dose, respectivamente), bem como melhora significativa na sobrevida após cada dose subsequente (p < 0,001). Conclusões: As vacinas foram efetivas na redução da gravidade da doença e dos óbitos nesta coorte de pacientes internados com COVID-19, e a aplicação de doses adicionais conferiu-lhes proteção vacinal cumulativa.

https://doi.org/10.36416/1806-3756/e20230145

Clinical Profile and its Associations with Coronary Angiography Results in a Public University Hospital
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Costa, Guilherme

; Ferreira, Esmeralci

; Albuquerque, Denilson Campos

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20220132

Resumo: En | Texto: En | PDF: En

Abstract Background: Ischemic heart disease is one of the most common causes of death worldwide. There are few data in the literature about the association of clinical profile and coronary angiography results in the Brazilian population. Objectives: To assess clinical variables and their associations with the results of coronary angiography and to evaluate the safety of coronary angiography in a public university hospital. Methods: From August 2015 to April 2018, 1 844 patients submitted to coronary angiography at the Pedro Ernesto University Hospital (HUPE, acronym in Portuguese) were enrolled in this cross-sectional study. They were evaluated by their clinical variables, angiographic results, and procedure complications. Logistic regression was used, and the criterion for determining significance was set at 5%. Results: The median age was 62 years, and most of the population (71%) were outpatients. Stable angina was the most common indication (62.9%). Only 19.7% underwent noninvasive cardiac testing. Arterial hypertension was the most prevalent (88.2%), followed by dyslipidemia (60.2%). Most patients (65%) had obstructive coronary artery disease (CAD). Left main coronary artery (LMCA) stenosis was found in 8.1% of patients. Older age, male sex, quantity of risk factors (RF), and peripheral artery disease were risk predictors for CAD. Death occurred only in 0.16% of the population, and acute coronary artery occlusion in 0.2%. Conclusion: Classic RF showed an association with CAD. The low incidence of complications suggests that coronary angiography is a safe procedure to be conducted in a public university hospital.

https://doi.org/10.36660/ijcs.20220132

10.

Performance of glyphosate-based products applied alone and in combination with herbicides in burndown
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Pereira, Bruno C. S.

; Braz, Guilherme B. P.

; Souza, Matheus de F.

; Reginaldo, Laís T. R. T.

; Ferreira, Camila J. B.

Revista Caatinga

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2023, Volume 36 Nº 4 Páginas 765 - 774

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT The no-tillage system is a conservation system that helps sustainability and agricultural production. The effectiveness of glyphosate control, applied alone or in combination with other herbicides, can be altered depending on the product’s formulation. The objective of the present study was to evaluate the effectiveness of glyphosate in formulations containing different salts and concentrations, applied alone and in combination with other herbicides, in controlling weeds in advanced stages in the pre-sowing burndown operation. The experiment was carried out in the field in an area with a history of high weed infestation. The experiment was conducted in a randomized block design, evaluating eleven treatments and four replicates. The treatments consisted of the application of three glyphosate-based formulations alone and in combination with clethodim and 2,4-D amine herbicides, in addition to a control without herbicide application. The evaluated variables were percentage of weed control and percentage of desiccation. A comparison of means by contrasts was performed to analyze the percentage of weed control. In general, treatments containing products based on glyphosate potassium salt in the composition have slightly better control performance compared to those consisting of glyphosate isopropylamine salt.

RESUMO O sistema de plantio direto é um sistema conservacionista que auxilia na sustentabilidade e a produção agrícola. A eficácia de controle do glyphosate, aplicado isoladamente ou em associação a outros herbicidas, pode ser alterada em função da formulação do produto. O objetivo do presente trabalho foi avaliar a eficácia de glyphosate em formulações contendo diferentes sais e concentrações, aplicado isolado e em associações a outros herbicidas, no controle de plantas daninhas em estádios avançados na operação de dessecação pré-semeadura. O experimento foi realizado a campo em área com histórico de elevada infestação de plantas daninhas. O experimento foi conduzido no delineamento de blocos casualizados, avaliando-se onze tratamentos e quatro repetições. Os tratamentos foram compostos pela aplicação de três formulações à base de glyphosate isolado e em associações com os herbicidas clethodim e 2,4-D amina, além de uma testemunha sem aplicação. As variáveis avaliadas foram porcentagem de controle das plantas daninhas e porcentagem de dessecação. Foi realizado uma comparação de médias por contrastes para analisar a porcentagem de controle de plantas daninhas. De maneira geral, tratamentos contendo produtos à base de glyphosate sal potássico na composição apresentam performance de controle ligeiramente superior em comparação com àqueles constituídos por glyphosate sal de isopropilamina.

https://doi.org/10.1590/1983-21252023v36n404rc

11.

Numerical investigations in non-watertight models based on a surface-independent discretization boundary element method nonwatertight non watertight surfaceindependent surface independent
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Cordeiro, Sérgio Gustavo Ferreira

; Teixeira, Guilherme Henrique

; Daumas, Gustavo de Oliveira

; Monteiro, Francisco Alex Correia

Latin American Journal of Solids and Structures

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2023, Volume 20 Nº 6 elocation e499

Resumo: En | Texto: En | PDF: En

Abstract It is well known that boundary integral equations are exact mathematical representations of the governing differential equations of a boundary value problem when the integrals are written over a closed-shape boundary representation (B-representation) of the domain, usually reffered to as a watertight B-representation. However, practical geometric design technics (namely, NURBS surfaces) often do not render a watertight B-representation. Non-watertight geometric models with small gaps and overlaps are often generated in the design stage of projects. Based on a proposed surface-independent discretization approach, the present study investigates how unsought gaps affect the response of boundary element models of linear elasticity problems. The developed surface-independent discretization is applied to discretize multiple-patches NURBS B-representation geometries. Linear triangular and quadrilateral elements are adopted to discretize the independent surfaces. Generalized discontinuous elements at the edges of the visible areas of the NURBS parametric spaces are detected by a Level Set function. An offset collocation strategy is adopted for the nodes at the edges of the visible part of the parametric spaces. Thus, singularities and near singularities due to collocation are avoided in the BEM equations. The influence of gaps in the convergence of the L2-norm of boundary displacement error is verified in a 3D example with an available analytical solution. A second example with available numerical solution is analyzed with a non-watertight BEM discretization for qualitative boundary field validation. Finally, a non-watertight B-representation geometry of a crane hook is analyzed. The obtained results have pointed out that, as long as the gaps (and overlaps) are small enough, BEM models built up from non-watertight geometries may produce valuable solutions for practical purposes. closedshape closed shape Brepresentation B (B-representation domain Brepresentation. representation. However namely, namely (namely surfaces Nonwatertight Non projects surfaceindependent surface approach problems multiplepatches multiple patches function Thus L2norm Lnorm L2 norm L D nonwatertight non validation Finally enough purposes

https://doi.org/10.1590/1679-78257573

12.

Synthesis of 1,2,3-Triazole Benzophenone Derivatives and Evaluation of in vitro Sun Protection, Antioxidant Properties, and Antiproliferative Activity on HT-144 Melanoma Cells
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Dias, Maria C. F.

; Sousa, Bianca L. de

; Ionta, Marisa

; Teixeira, Róbson R.

; Goulart, Thiago Q.

; Ferreira-Silva, Guilherme Á.

; Pilau, Eduardo J.

; Santos, Marcelo H. dos

Journal of the Brazilian Chemical Society

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Mar 2021, Volume 32 Nº 3 Páginas 572 - 587

Resumo: En | Texto: En | PDF: En

Benzophenones display several biological activities, including antioxidant, anticancer, and photoprotective. Furthermore, antioxidants can minimize both ultraviolet absorption and tumor development. In the present investigation, a series of twenty-six 1,2,3-triazole-benzophenone derivatives were synthesized and had their antioxidant, anticancer, and photoprotective effects evaluated. For the compounds synthesis, 4,4’-dihydroxybenzophenone (1a) and 2,4-dihydroxybenzophenone (1b) were propargylated, affording the alkynes bis(4-(prop-2-yn-1-yloxy))benzophenone (2a) and (2-hydroxy-4-(prop-2-yn-1-yloxy))benzophenone (2b), respectively. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between the compounds 2a/2b and several benzyl azides gave the 1,2,3-triazole-benzophenone derivatives with yields ranging from 35 to 95%. The 1,2,3-triazole-benzophenone derivatives at the concentration of 0.2 μg mL-1 (a no-cytotoxic concentration) exhibited a solar protection factor (SPF) comparable to positive control benzophonen-3 (BP-3). Concerning their antioxidant and cytotoxic effects, the derivatives from 1b showed high in vitro antioxidant effects as well as cytotoxicity against A549 (lung carcinoma), MCF-7 (breast carcinoma), and HT-144 (metastatic melanoma) cell lines, without significant cytotoxicity to a non-cancerous cell line. Derivatives 19, 20, and 24 induced cell death and cell cycle arrest at G1/S in HT-144 melanoma cells.

https://doi.org/10.21577/0103-5053.20200211 324 downloads

13.

Synthesis of 1,2,3-Triazole Derivatives of Hydnocarpic Acid Isolated from Carpotroche brasiliensis Seed Oil and Evaluation of Antiproliferative Activity
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Osorio, Liseth S.

; Ionta, Marisa

; Demuner, Antonio J.

; Sousa, Bianca L. de

; Ferraz, Guilherme O.

; Varejão, Eduardo V. V.

; Ferreira-Silva, Guilherme A.

; Pilau, Eduardo J.

; Silva, Evandro

; Santos, Marcelo H. dos

Journal of the Brazilian Chemical Society

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Dez 2020, Volume 31 Nº 12 Páginas 2500 - 2510

Resumo: En | Texto: En | PDF: En

Carpotroche brasiliensis is a tree native to Brazil, belonging to the family Flacurtiaceae, whose seeds contain a group of cyclopentenyl fatty acids: gorlic (12%), chaulmugric (27%), and hydnocarpic (48.7%). These compounds are considered the main therapeutic agents in the treatment of leprosy. In the present study, a series of novel triazole compounds were obtained by conjugation between hydnocarpic acid and functionalized azides via copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC). Hydnocarpic acid and its derivatives were tested against estrogen-positive breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), and non-small cell lung cancer (A549) cell lines. The (R)-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl-11-(cyclopent-2-en-1-yl)undecanoate (8) displayed promising antiproliferative activity against A549 cells. We demonstrated that this compound selectively inhibited the viability of A549 cell cultures. Furthermore, compound 8 inhibited the clonogenic capacity of A549 cells, and this effect was associated to its ability to inhibit cell cycle progression at G1 phase. These findings indicate that 8 is a promising antitumor agent on A549 cells and support further studies to evaluate the molecular mechanisms underlying its antiproliferative activity. In addition, hydnocarpic acid should be considered as a promising chemical prototype to obtain novel antineoplastic agents.

https://doi.org/10.21577/0103-5053.20200125 331 downloads

14.

New Insights into the Partitioning of Phenothiazine Dyes in Aqueous Two-Phase Systems
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Coelho, Yara L.

; Agudelo, Álvaro J. P.

; Ferreira, Guilherme M. D.

; Ferreira, Gabriel M. D.

; Castro, Alan S. B. de

; Hudson, Eliara A.

; Pires, Ana Clarissa S.

; Silva, Luis H. M. da

Journal of the Brazilian Chemical Society

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Ago 2020, Volume 31 Nº 8 Páginas 1700 - 1713

Resumo: En | Texto: En | PDF: En

Aqueous two-phase systems (ATPSs) have proven to be efficient and environmentally safe methods for extracting chemical species. However, the driving forces behind the partition of solutes in these systems are still little understood. A complete thermodynamic partitioning of phenothiazine dyes was investigated in poly(ethylene oxide) (PEO) + salt + water ATPSs. Standard transfer parameters (Gibbs free energy change (ΔtrGº), enthalpy change (ΔtrHº) and entropy change (TΔtrSº)) were evaluated, and their dependence on the dye structure, electrolyte nature and tie line length (TLL). All phenothiazine dyes are concentrated predominantly in the polymer enriched phase, with ΔtrGº values ranging from -4.1 up to -13.4 kJ mol-1. Due to the dye-PEO attractive interactions that occur mainly via benzene condensed ring present in the structures of phenothiazine dyes, the partitioning of these dyes was enthalpically driven, with -11.4 ≥ ΔtrHº ≥ -52 kJ mol-1 and -4.93 ≥ TΔtrSº ≥ -38 kJ mol-1.

https://doi.org/10.21577/0103-5053.20200056 211 downloads

15.

Comment on the study Coronary Artery Bypass Surgery in Brazil: Analysis of the National Reality Through the Bypass Registry that was presented at the 46th Congress of the Brazilian Society of Cardiovascular Surgery, Nova Lima, BH, Brazil, April 5 and 6, 2019
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Dallan, Luís Alberto O.

; Paez, Rodrigo Pereira

; Hossne Junior, Nelson Américo

; Santo, José Amalth do Espírito

; Berwanger, Otavio

; Santos, Renato Hideo Nakagawa

; Kalil, Renato Abdala Karam

; Jatene, Fabio B.

; Cavalcanti, Alexandre Biasi

; Zilli, Alexandre Cabral

; Bettiati Jr, Luiz Carlos

; Figueira, Fernando Augusto Marinho dos Santos

; D’Azevedo, Stephanie Steremberg Pires

; Soares, Marcelo José Ferreira

; Fernandes, Marcio Pimentel

; Ardito, Roberto Vito

; Bogdan, Renata Andrea Barberio

; Campagnucci, Valquíria Pelisser

; Nakasako, Diana

; Rodrigues, Clarissa Garcia

; Rodrigues Junior, Anilton Bezerra

; Cascudo, Marcelo Matos

; Atik, Fernando Antibas

; Lima, Elson Borges

; Nina, Vinicius José da Silva

; Heluy, Renato Albuquerque

; Azeredo, Lisandro Gonçalves

; Henrique Junior, Odilon Silva

; Mendonça, José Teles de

; Silva, Katharina Kelly de Oliveira Gama

; Pandolfo, Marcelo

; Lima Júnior, José Dantas de

; Faria, Renato Max

; Santos, Jonas Gonçalves dos

; Coelho, Guilherme Henrique Biachi

; Pereira, Sergio Nunes

; Senger, Roberta

; Buffolo, Enio

; Caputi, Guido Marco

; Oliveira, Juliana Aparecida Borges de

; Gomes, Walter J.

Brazilian Journal of Cardiovascular Surgery

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Ago 2019, Volume 34 Nº 4 Páginas 504 - 506

Resumo: En | Texto: En | PDF: En

https://doi.org/10.21470/1678-9741-2019-0606 335 downloads

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