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1.
Herbaceous forage legumes with diverse structural traits can display similar productive responses under different harvest frequencies
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Silva Neto, Abdias José da
; Santos, Mércia Virginia Ferreira dos
; Silva, Valdson José da
; Coelho, Janerson José
; Mello, Alexandre Carneiro Leão de
; Simões Neto, Djalma Euzébio
; Cunha, Márcio Vieira da
.
ABSTRACT: One of the main issues related to the management of forage legumes is the fact that these plants can be found in a broad diversity of morphology, structures and growth habits. This study evaluated the structural and productive characteristics of forage legumes with different growth habits [Clitoria ternatea L.; Desmanthus pernambucanus (L.) Thellung; and Stylosanthes spp. cv. Campo Grande], in response to two harvesting frequencies (60 and 90 days). The experimental design was completely randomized in blocks, with a split-plot scheme and four replications (n=4). The type of forage legume influenced the number of secondary branches, the number of leaves per branch, leaf area index (LAI), light interception (LI), percentage of leaves and stems (%), leaf/stem ratio, and pod production (P<0.05). D. pernambucanus had the lowest LI and LAI (P < 0.05). Stylosanthes spp. cv. Campo Grande and C. ternatea showed a greater leaf percentage and leaf/stem ratio (P < 0.05). There was an effect of the harvesting frequency on the percentage of stems, leaves, pod production, and total production (P < 0.05). Longer harvesting frequencies affected differently these legumes, especially the accumulation of stems in D. pernambucanus, which displayed an intense increase after 60 days of growth. The choice of the best harvesting frequency for these legumes evaluated should consider the proposal of the usage. In our study, it was shown that harvesting at 60 days did not affect the total forage mass accumulated, which possibly is the most advantageous choice.
RESUMO: Uma das principais questões relacionadas ao manejo de leguminosas forrageiras é o fato de que essas plantas podem ser encontradas em uma ampla diversidade de morfológica, estruturais e de hábitos de crescimento. O objetivo deste estudo foi avaliar características morfológicas, estruturais e produtivas de leguminosas forrageiras com diferentes hábitos de crescimento [Clitoria ternatea L.; Desmanthus pernambucanus (L.) Thellung; e Stylosanthes spp. cv. Campo Grande], em resposta a duas frequências de colheita (60 e 90 dias). O delineamento experimental foi inteiramente casualizado em blocos, com esquema de parcelas subdivididas e quatro repetições (n=4). O tipo de leguminosa forrageira influenciou no número de ramos secundários, número de folhas por ramo, índice de área foliar (IAF), interceptação luminosa (IL), porcentagem de folhas e colmos (%), razão folha/colmo e produção de vagens (P<0,05). D. pernambucanus apresentou os menores IL e IAF (P<0,05). Stylosanthes spp. cv. Campo Grande e C. ternatea apresentaram maior porcentagem de folhas e relação folha/colmo (P<0,05). Houve efeito da frequência de colheita na porcentagem de produção de hastes, folhas e vagens e na produção total (P<0,05). Frequências de colheita mais longas afetaram de forma diferente as leguminosas forrageiras avaliadas, principalmente o acúmulo de caules em D. pernambucanus, que apresentou aumento intenso após 60 dias de crescimento. A escolha da melhor frequência de colheita para essas leguminosas avaliadas deve levar em consideração a sua forma de uso. No presente estudo, foi demonstrado que a colheita aos 60 dias não afetou a massa forragem total acumulada, o que possivelmente é a escolha mais vantajosa.
2.
Dirofilaria immitis is endemic in rural areas of the Brazilian Amazonas state capital, Manaus
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Barbosa, Ulysses Carvalho
; Nava, Alessandra Ferreira Dales
; Ferreira Neto, José Vicente
; Dias, Cindy Alves
; Silva, Viviane Costa da
; Mesquita, Hugo Guimarães de
; Sampaio, Raquel Telles de Moreira
; Barros, Wanilze Gonçalves
; Farias, Emanuelle de Sousa
; Silva, Tullio Romão Ribeiro da
; Crainey, James Lee
; Tadei, Wanderli Pedro
; Koolen, Hector Henrique Ferreira
; Pessoa, Felipe Arley Costa
.
Revista Brasileira de Parasitologia Veterinária
- Métricas do periódico
Abstract The canine filarial parasite Dirofilaria immitis has not been reported in Brazil´s Amazonas state capital, Manaus, for over a century. Here, we report one imported and 27 autochthonous D. immitis infections from a microfilarial survey of 766 domestic dog blood samples collected between 2017 and 2021 in Manaus. An Overall prevalence estimate of 15.44% (23/149) was calculated from our two rural collection sites; a prevalence of 1.22% (4/328) was estimated at our periurban collection site, and an overall prevalence of 0.35% (1/289) was calculated from our two urban clinic collections. Our data suggest that in the urban areas of Manaus, where the parasites are very likely vectored by the same species of mosquito that historically vectored Wuchereria bancrofti (Culex quinquefasciatus), prevalence levels are very low and possibly maintained by an influx from rural areas where sylvatic reservoirs and/or more favorable vector transmission dynamics maintain high prevalences.
Resumo O parasita filarial canino, Dirofilaria immitis, causa doença zoonótica, mas não tem sido registrado em Manaus, capital do estado do Amazonas, há mais de um século. Neste trabalho, foi relatado uma infecção por D. immitis alóctone e 27 autóctones de um levantamento de microfilárias em 766 amostras de sangue em cães domésticos, coletados entre 2017 e 2021 em Manaus. A prevalência de 15,44% (23/149) foi estabelecida em áreas rurais, 1,22% (4/328) para áreas periurbanas e de 0,35% (1/289) para duas clínicas veterinárias localizadas na zona urbana da cidade. Estes dados sugerem, portanto, que nas áreas urbanas de Manaus, nas quais o parasita é provavelmente vetorizado pela mesma espécie de mosquito que, historicamente, transmitiu Wuchereria bancrofti (Culex quinquefasciatus). Também os níveis de prevalência são baixos e, possivelmente, mantidos por um influxo de áreas rurais onde reservatórios silvestres e/ou dinâmicas de transmissão vetorial mais favoráveis mantêm uma prevalência mais elevada.
3.
Use of Iron Ore Tailing as Raw Material for Two Products: Sodium Silicate and Geopolymers
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Prates, Caroline D.
; Lima, Athos S.
; Ferreira, Igor C.
; Paula, Fabiano G. F. de
; Pinto, Paula S.
; Ardisson, José D.
; Lago, Rochel M.
; Teixeira, Ana Paula C.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
In this work, iron ore tailing (IOT) was used for the production of two different materials: sodium silicate and geopolymers. Initially, reactions of IOT with NaOH were carried out by hydrothermal reaction in autoclave at 200 °C (1:1.5 and 1:2.5 SiO2:NaOH molar ratio) and reaction times of 4 and 8 h. X-ray fluorescence by dispersive energy (XRF), X-ray diffraction (XRD), Mössbauer spectroscopy, scanning electron microscopy (SEM-EDS) and titrations showed that IOT:NaOH ratios of 1:2.5 and reaction time 8 h completely dissolved the quartz from the IOT, obtaining a solid fraction consisting mainly of hematite and an aqueous phase of sodium silicate, which showed contents of ca. 23% SiO2 and 19% Na2O. This sodium silicate obtained was then combined with IOT (25 and 50 wt.%) to produce geopolimeric material with excellent physico-chemical properties, fast curing time and very good compressive strength results, which ranged from 41 to 58 MPa and many potential applications.
4.
Influence of the Local Structure on the Photocatalytic Properties of Zinc Spinel Ferrite Nanoparticles
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Biazati, Luciana B.
; Lorenzini, Lucas
; Ferreira, Sandra A. D.
; Porto, Arilza O.
; Castro, Eustáquio V. R. de
; Fabris, José D.
; Freitas, Marcos B. J. G. de
; Lelis, Maria de Fátima F.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
The correlation between iron distribution in octahedral or tetrahedral sites in synthetic magnetite and zinc spinel ferrites and their catalytic properties were investigated in this work. The zinc-doped nanomagnetites were prepared by co-precipitation method and annealed at 420 °C. X-ray diffraction, UV-Vis, X-ray absorption and 57Fe Mössbauer spectroscopies were used to identify iron sites. The obtained results showed that ZnII replaces the relatively smaller FeIII cation in the tetrahedral sites, increasing the cubic lattice dimension, and this replacement remarkably enhances the catalytic effectiveness of the Zn-spinel ferrite towards the indigo carmine degradation compared to undoped magnetite. The indigo carmine degradation experiments were carried out using photo-Fenton method in which 50 mL of indigo carmine dye aqueous solutions (20 mg L−1, pH 3.0), 20 mg ZnxFe(3-x)O4, and 2.0 mL H2O2 (aqueous solution at 0.028 mol L−1) were placed under UV light at 25 °C. Under these experimental conditions the degradation rate of indigo carmine was superior to 98%.
5.
Milonine attenuates the lipopolysaccharide-induced acute lung injury in mice by modulating the Akt/NF-κB signaling pathways
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BERNARDO, LARISSA R.
; FERREIRA, LAÉRCIA KARLA D.P.
; FERREIRA, LARISSA A.M.P.
; VIEIRA, COSMO ISAÍAS D.
; OLIVEIRA, JOÃO BATISTA DE
; LIMA, LOUISE M. DE
; ALVES, ADRIANO FRANCISCO
; ARAÚJO, RUBENS S.
; MAIA, MAYARA S.
; SCOTTI, MARCUS T.
; BARBOSA FILHO, JOSÉ MARIA
; PIUVEZAM, MARCIA REGINA
.
Anais da Academia Brasileira de Ciências
- Métricas do periódico
Abstract Acute lung injury is an inflammation that triggers acute respiratory distress syndrome with perialveolar neutrophil infiltration, alveolar-capillary barrier damage, and lung edema. Activation of the toll-like receptor 4 complex (TLR4/MD2) and its downstream signaling pathways are responsible for the cytokine storm and cause alveolar damage. Due to the complexity of this pulmonary inflammation, a defined pharmacotherapy has not been established. Thus, this study evaluated the anti-inflammatory potential of milonine, an alkaloid of Cissampelos sympodialis Eichl, in an experimental model of lung inflammation. BALB/c mice were lipopolysaccharide-challenged and treated with milonine at 2.0 mg/kg. Twenty-four hours later, the bronchoalveolar fluid, peripheral blood, and lungs were collected for cellular and molecular analysis. The milonine treatment decreased the cell migration (mainly neutrophils) to the alveoli, the pulmonary edema, and the cytokine levels (IL-1β, IL-6, TNF-α). The systemic IL-6 level was also reduced. The milonine docking analysis demonstrated hydrophobic interaction at TLR4/MD2 groove with Ile124 and Phe126 amino acids. Indeed, the alkaloid downregulated the kinase-Akt and NF-κB through TLR4/MD2. Therefore, milonine is an effective inflammatory modulator being a potential molecule for the treatment of lung inflammation.
6.
Aquatic pollutants are associated with reproductive alterations and genotoxicity in estuarine fish (Sciades herzbergii - Bloch, 1794) from the Amazon Equatorial Coast
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Noleto, K. S.
; Mendes, D. C. S.
; Carvalho, I. F. S.
; Ribeiro, D. L. S.
; Santos, D. M. S.
; Ferreira, A. P. M.
; Marques, A. L. B.
; Carvalho Neta, R. N. F.
; Tchaicka, L.
; Torres Júnior, J. R. S.
.
Resumo Os estuários estão constantemente sujeitos a impactos ambientais de atividades antropogênicas, como pesca, movimentação portuária, indústria ou esgoto doméstico, onde os peixes são um dos animais aquáticos mais atingidos, sendo capazes de refletir os impactos diretamente em seu organismo. Assim, o objetivo desse estudo foi realizar o biomonitoramento de um estuário da Costa Equatorial Amazônica por meio de análises de PAHs (Hidrocarboneto Policiclico Aromáticos) na água, além de metais traços, alterações histopatológicas e análises de micronúcleos eritrocitários em Sciades herzbergii.. O S. herzbergii foi utilizado como espécie modelo, devido seu comportamento estuarino residente. Amostras de gônadas e brânquias foram submetidas a avaliações histopatológicas. A quantificação de metais traços foi realizada em amostras de músculos esqueléticos dos animais coletados, onde foram encontrados teores de Chumbo (Pb), Cobre (Cu), Zinco (Zn), Cádmio (Cd), Magnésio (Mg), Ferro (Fe) e Alumínio (AL), e foram encontradas em concentrações acima dos limites recomendados, à exceção do Cádmio (Cd). A análise dos PAHs revelou a presença de Naftaleno e Acenafteno nas amostras de água. Análises histopatológicas e genotóxicas revelaram lesões em 100% dos espécimes estudados, resultados estes, potencialmente associados à presença de PAH e de metais traços, tanto na água quanto nos tecidos animais, comprovando um cenário geral de contaminação ambiental implicando diretamente em risco à saúde e sobrevivência da biota local. Esse estudo mostra a relevância do biomonitoramento contínuo dos ecossistemas estuarinos, afim de nortear autoridades no manejo de efluentes e assegurar o desenvolvimento evolutivo de espécies estuarinas, sobretudo dos peixes de importância na culinária regional, diretamente relacionados à segurança alimentar humana.
Abstract Estuaries are constantly subject to continuous environmental impacts of human activities, such as fisheries, port or industry, and domestic sewage, with fish being one of the most affected aquatic animals, reflecting the impacts directly on their bodies. Thus, the aim of this study was to carry out the biomonitoring of an estuary located on the Amazonian Equatorial Coast through analysis of PAHs (Polycyclic Aromatic Hydrocarbons) in the water, in addition to trace metals, histopathological alterations and analysis of erythrocyte micronuclei in Sciades herzbergii. S. herzbergii was used as a model species, due to its estuarine-resident behavior. Gonad and gill samples were subjected to histopathological evaluations. The quantification of trace metals was performed in samples of skeletal muscles of the animals collected, where concentrations of Lead (Pb), Copper (Cu), Zinc (Zn), Cadmium (Cd), Magnesium (Mg), Iron (Fe) and Aluminum (Al) were found. Except for Cadmium (Cd), all the concentrations were above the recommended limits. The PAHs analysis revealed the presence of Naphthalene and Acenaphthene in the water samples Histopathological and genotoxic analyses revealed of lesions in 100% of the study specimens. Thus, the histological and genotoxic alterations found in 100% of S. herzbergii specimens captured in São José Bay-MA are potentially associated with PAH concentrations present in the water. These results are potentially associated with the presence of PAH and trace metals, both in water and in animal tissues, inferring a general scenario of environmental contamination which directly implies a risk to the health and survival of the local biota. This study shows the relevance of continuous biomonitoring of estuarine ecosystems, in order to guide authorities regarding sewage management and ensure the evolutionary development of estuarine species, especially fishes of importance in the local cuisine, therefore related to human food security.
7.
Avaliação da Energética Prevista nos Modelos Regionais BRAMS, ETA e WRF: Parte I - Inverno
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Gan, Manoel A.
; Ferreira, Sérgio H.S.
; Piva, Everson D.
; Rozante, José R.
; Garcia, José R.M.
; Fernandes, Alex A.
; Neves, André L.O.
; Silva, Vinícios M.
.
Resumo O objetivo deste estudo é avaliar os termos da equação da tendência da energia cinética do distúrbio (K’) nas previsões de 24 h e 48 h dos modelos regionais BRAMS, WRF e ETA. Estes modelos foram integrados operacionalmente no Centro de Previsão de Tempo e Estudos Climáticos (CPTEC). O período de avaliação foi de 1 de junho a 31 de agosto de 2016, sendo que o domínio utilizado foi a região da América do Sul. A resolução horizontal dos modelos é de 5 km e a temporal é de 6 horas. As condições iniciais e de contorno foram obtidas do Global Forecast System (GFS) do National Centers for Environmental Prediction (NCEP), com resolução horizontal de 0,25°. Os modelos foram inicializados apenas com a análise das 1200 UTC. Os modelos foram integrados com a versão não-hidrostática, sendo que o WRF utilizou a parametrização cumulus de Kain-Frisch, o ETA a parametrização culumus de Betts-Miller e o BRAMS Grell e Freitas. Em geral, os três modelos subestimam K’ nas latitudes médias, principalmente sobre os oceanos, porém o ETA é o que menos subestima e o WRF o que tem o maior viés negativo. Com relação aos termos de conversão baroclínica e barotrópica, além do termo de convergência do fluxo ageostrófico, os três modelos apresentam um padrão semelhante aos das análises numéricas do GFS.
Abstract The aim of this study is to evaluate the terms of the eddy kinetic energy (K’) equation in the 24 h and 48 h forecasts of the regional models BRAMS, WRF and ETA. These models were operationally integrated at the Weather Forecast and Climate Studies Center (CPTEC). The evaluation period was from June 1 to August 31, 2016 and the domain was the region of South America. The horizontal resolution of the three models is 5 km and the temporal is 6 h. The initial and boundary conditions were obtained from the Global Forecast System (GFS) of the National Centers for Environmental Prediction (NCEP), with a horizontal resolution of 0.25°. The models were initialized only with the analysis of 1200 UTC. The non-hydrostatic version of the three models was run, with WRF using Kain-Frisch cumulus parameterization, ETA Betts-Miller culumus parameterization and BRAMS Grell and Freitas. In general, the three models underestimate K‘ in mid-latitudes, mainly over the oceans, however, ETA is the one that underestimates the least and WRF the most. Regarding the terms of baroclinic and barotropic conversion, in addition to the term of ageostrophic flow convergence, the three models have a similar pattern of these three terms with that of GFS numerical analysis.
8.
Forced Degradation Study and Development of a Stability-Indicating Method for Amoxicillin Capsules According to ANVISA Guidelines
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Gallo, Margareth B. C
; Nascimento, Diogo D. do
; Nunes, Nelson M
; Sousa, Flávia F. M. de
; Boniatti, Janine
; Aguiar, José L. N. de
; Medeiros, Juliana J. S
; Esteves, Alessandra L
; Guerra, Graça M. S
; Ferreira, Luiz E. M
; Regis, Lucas G. I
; Seiceira, Rafael C
; Moncorvo, Fabiana M. S. U
; Chaves, Marcelo H. C
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
This study aimed to develop a reliable stability-indicating method (SIM) for amoxicillin 500 mg capsules (DP-drug product). A literature review addressing amoxicillin (AMX; DS-drug substance) forced degradation studies and the existing SIMs was conducted to verify the most significant outcomes. Subsequently, the forced degradation of DP and DS was carried out following the Brazilian Health Surveillance Agency (ANVISA) guidelines, including thermal degradation (dry and wet heat), acidic and alkaline hydrolyses, hydrogen peroxide oxidation, reaction with copper, and photodegradation. Both DS and DP were more susceptible to 0.015 M NaOH, resulting in approximately 50% degradation. AMX DS and DP were not significantly photodegraded, but some degradation products (PDegs) showed susceptibility to light exposure. Thermodegraded samples showing ≥ 10% degradation exhibited modified profiles in thermogravimetric (TG) and differential scanning calorimetric (DSC) analyses. The X-ray powder diffraction patterns (XRPD) of DS samples exposed to dry and wet heat displayed complete amorphization of AMX, attesting to the occurrence of physical degradation concomitantly with chemical degradation, which can alter the drug’s bioavailability. In contrast, the thermodegraded DP samples exhibited intact AMX crystals interspersed with the amorphous form, perhaps partly protected by the excipient. The validated SIM was able to detect and quantify about 80 PDegs.
9.
Morphophysiology of mini watermelon in hydroponic cultivation using reject brine and substrates
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Silva, José S. da
; Sá, Francisco V. da S.
; Dias, Nildo da S.
; Ferreira Neto, Miguel
; Jales, Gleydson D.
; Fernandes, Pedro D.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
- Métricas do periódico
RESUMO Objetivou-se avaliar o crescimento e os aspectos fisiológicos da mini melancieira ‘Sugar Baby’ em sistema hidropônico com diferentes substratos e misturas de rejeito salino no preparo da solução nutritiva. Para isso, o experimento foi desenvolvido em estufa plástica, usando delineamento experimental de blocos casualizados, em esquema fatorial 5 x 4, correspondentes à combinação de cinco misturas de rejeito salino (condutividade elétrica - CE = 9,50 dS m-1) e água de torneira (CE = 0,54 dS m-1) e quatro tipos de substratos (fibra de coco, areia lavada, 70% areia lavada + 30% casca de arroz e 40% areia lavada + 60% casca de arroz), com quatro repetições. O uso da mistura de rejeito salino e água de torneira com CE acima de 4,00 dS m-1 no preparo da solução nutritiva da mini melancieira reduziu de forma acentuada o crescimento das plantas. O aumento da eficiência de carboxilação e da atividade na cadeia transportadora de elétrons, atuam como mecanismos de tolerância para compensar a fotossíntese líquida da mini melancieira sob estresse salino. A fibra de coco proporcionou o melhor crescimento e atividade fotossintética da mini melancieira, e o substrato com 100% areia lavada proporcionou o menor desempenho.
HIGHLIGHTS Growth and leaf area of mini watermelon in hydroponic cultivation are reduced at electrical conductivity above 4.00 dS m-1. Electrical conductivity of up to 6.90 dS m-1 does not reduce the net photosynthesis of mini watermelon in hydroponic cultivation. Coconut fiber is the best hydroponic substrate for mini watermelon.
https://doi.org/10.1590/1807-1929/agriambi.v25n6p402-408
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10.
Práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras: uma análise secundária do estudo Fluid-TRIPS
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Freitas, Flavio Geraldo Rezende de
; Hammond, Naomi
; Li, Yang
; Azevedo, Luciano Cesar Pontes de
; Cavalcanti, Alexandre Biasi
; Taniguchi, Leandro
; Gobatto, André
; Japiassú, André Miguel
; Bafi, Antonio Tonete
; Mazza, Bruno Franco
; Noritomi, Danilo Teixeira
; Dal-Pizzol, Felipe
; Bozza, Fernando
; Salluh, Jorge Ibrahin Figueira
; Westphal, Glauco Adrieno
; Soares, Márcio
; Assunção, Murillo Santucci César de
; Lisboa, Thiago
; Lobo, Suzana Margarete Ajeje
; Barbosa, Achilles Rohlfs
; Ventura, Adriana Fonseca
; Souza, Ailson Faria de
; Silva, Alexandre Francisco
; Toledo, Alexandre
; Reis, Aline
; Cembranel, Allan
; Rea Neto, Alvaro
; Gut, Ana Lúcia
; Justo, Ana Patricia Pierre
; Santos, Ana Paula
; Albuquerque, André Campos D. de
; Scazufka, André
; Rodrigues, Antonio Babo
; Fernandino, Bruno Bonaccorsi
; Silva, Bruno Goncalves
; Vidal, Bruno Sarno
; Pinheiro, Bruno Valle
; Pinto, Bruno Vilela Costa
; Feijo, Carlos Augusto Ramos
; Abreu Filho, Carlos de
; Bosso, Carlos Eduardo da Costa Nunes
; Moreira, Carlos Eduardo Nassif
; Ramos, Carlos Henrique Ferreira
; Tavares, Carmen
; Arantes, Cidamaiá
; Grion, Cintia
; Mendes, Ciro Leite
; Kmohan, Claudio
; Piras, Claudio
; Castro, Cristine Pilati Pileggi
; Lins, Cyntia
; Beraldo, Daniel
; Fontes, Daniel
; Boni, Daniela
; Castiglioni, Débora
; Paisani, Denise de Moraes
; Pedroso, Durval Ferreira Fonseca
; Mattos, Ederson Roberto
; Brito Sobrinho, Edgar de
; Troncoso, Edgar M. V.
; Rodrigues Filho, Edison Moraes
; Nogueira, Eduardo Enrico Ferrari
; Ferreira, Eduardo Leme
; Pacheco, Eduardo Souza
; Jodar, Euzebio
; Ferreira, Evandro L. A.
; Araujo, Fabiana Fernandes de
; Trevisol, Fabiana Schuelter
; Amorim, Fábio Ferreira
; Giannini, Fabio Poianas
; Santos, Fabrício Primitivo Matos
; Buarque, Fátima
; Lima, Felipe Gallego
; Costa, Fernando Antonio Alvares da
; Sad, Fernando Cesar dos Anjos
; Aranha, Fernando G.
; Ganem, Fernando
; Callil, Flavio
; Costa Filho, Francisco Flávio
; Dall´Arto, Frederico Toledo Campo
; Moreno, Geovani
; Friedman, Gilberto
; Moralez, Giulliana Martines
; Silva, Guilherme Abdalla da
; Costa, Guilherme
; Cavalcanti, Guilherme Silva
; Cavalcanti, Guilherme Silva
; Betônico, Gustavo Navarro
; Betônico, Gustavo Navarro
; Reis, Hélder
; Araujo, Helia Beatriz N.
; Hortiz Júnior, Helio Anjos
; Guimaraes, Helio Penna
; Urbano, Hugo
; Maia, Israel
; Santiago Filho, Ivan Lopes
; Farhat Júnior, Jamil
; Alvarez, Janu Rangel
; Passos, Joel Tavares
; Paranhos, Jorge Eduardo da Rocha
; Marques, José Aurelio
; Moreira Filho, José Gonçalves
; Andrade, Jose Neto
; Sobrinho, José Onofre de C
; Bezerra, Jose Terceiro de Paiva
; Alves, Juliana Apolônio
; Ferreira, Juliana
; Gomes, Jussara
; Sato, Karina Midori
; Gerent, Karine
; Teixeira, Kathia Margarida Costa
; Conde, Katia Aparecida Pessoa
; Martins, Laércia Ferreira
; Figueirêdo, Lanese
; Rezegue, Leila
; Tcherniacovsk, Leonardo
; Ferraz, Leone Oliveira
; Cavalcante, Liane
; Rabelo, Ligia
; Miilher, Lilian
; Garcia, Lisiane
; Tannous, Luana
; Hajjar, Ludhmila Abrahão
; Paciência, Luís Eduardo Miranda
; Cruz Neto, Luiz Monteiro da
; Bley, Macia Valeria
; Sousa, Marcelo Ferreira
; Puga, Marcelo Lourencini
; Romano, Marcelo Luz Pereira
; Nobrega, Marciano
; Arbex, Marcio
; Rodrigues, Márcio Leite
; Guerreiro, Márcio Osório
; Rocha, Marcone
; Alves, Maria Angela Pangoni
; Alves, Maria Angela Pangoni
; Rosa, Maria Doroti
; Dias, Mariza D’Agostino
; Martins, Miquéias
; Oliveira, Mirella de
; Moretti, Miriane Melo Silveira
; Matsui, Mirna
; Messender, Octavio
; Santarém, Orlando Luís de Andrade
; Silveira, Patricio Júnior Henrique da
; Vassallo, Paula Frizera
; Antoniazzi, Paulo
; Gottardo, Paulo César
; Correia, Paulo
; Ferreira, Paulo
; Torres, Paulo
; Silva, Pedro Gabrile M. de Barros e
; Foernges, Rafael
; Gomes, Rafael
; Moraes, Rafael
; Nonato filho, Raimundo
; Borba, Renato Luis
; Gomes, Renato V
; Cordioli, Ricardo
; Lima, Ricardo
; López, Ricardo Pérez
; Gargioni, Ricardo Rath de Oliveira
; Rosenblat, Richard
; Souza, Roberta Machado de
; Almeida, Roberto
; Narciso, Roberto Camargo
; Marco, Roberto
; waltrick, Roberto
; Biondi, Rodrigo
; Figueiredo, Rodrigo
; Dutra, Rodrigo Santana
; Batista, Roseane
; Felipe, Rouge
; Franco, Rubens Sergio da Silva
; Houly, Sandra
; Faria, Sara Socorro
; Pinto, Sergio Felix
; Luzzi, Sergio
; Sant’ana, Sergio
; Fernandes, Sergio Sonego
; Yamada, Sérgio
; Zajac, Sérgio
; Vaz, Sidiner Mesquita
; Bezerra, Silvia Aparecida Bezerra
; Farhat, Tatiana Bueno Tardivo
; Santos, Thiago Martins
; Smith, Tiago
; Silva, Ulysses V. A.
; Damasceno, Valnei Bento
; Nobre, Vandack
; Dantas, Vicente Cés de Souza
; Irineu, Vivian Menezes
; Bogado, Viviane
; Nedel, Wagner
; Campos Filho, Walther
; Dantas, Weidson
; Viana, William
; Oliveira Filho, Wilson de
; Delgadinho, Wilson Martins
; Finfer, Simon
; Machado, Flavia Ribeiro
.
Revista Brasileira de Terapia Intensiva
- Métricas do periódico
RESUMO Objetivo: Descrever as práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras e compará-las com as de outros países participantes do estudo Fluid-TRIPS. Métodos: Este foi um estudo observacional transversal, prospectivo e internacional, de uma amostra de conveniência de unidades de terapia intensiva de 27 países (inclusive o Brasil), com utilização da base de dados Fluid-TRIPS compilada em 2014. Descrevemos os padrões de ressuscitação volêmica utilizados no Brasil em comparação com os de outros países e identificamos os fatores associados com a escolha dos fluidos. Resultados: No dia do estudo, foram incluídos 3.214 pacientes do Brasil e 3.493 pacientes de outros países, dos quais, respectivamente, 16,1% e 26,8% (p < 0,001) receberam fluidos. A principal indicação para ressuscitação volêmica foi comprometimento da perfusão e/ou baixo débito cardíaco (Brasil 71,7% versus outros países 56,4%; p < 0,001). No Brasil, a percentagem de pacientes que receberam soluções cristaloides foi mais elevada (97,7% versus 76,8%; p < 0,001), e solução de cloreto de sódio a 0,9% foi o cristaloide mais comumente utilizado (62,5% versus 27,1%; p < 0,001). A análise multivariada sugeriu que os níveis de albumina se associaram com o uso tanto de cristaloides quanto de coloides, enquanto o tipo de prescritor dos fluidos se associou apenas com o uso de cristaloides. Conclusão: Nossos resultados sugerem que cristaloides são usados mais frequentemente do que coloides para ressuscitação no Brasil, e essa discrepância, em termos de frequências, é mais elevada do que em outros países. A solução de cloreto de sódio 0,9% foi o cristaloide mais frequentemente prescrito. Os níveis de albumina sérica e o tipo de prescritor de fluidos foram os fatores associados com a escolha de cristaloides ou coloides para a prescrição de fluidos.
Abstract Objective: To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods: This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results: On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion: Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation.
https://doi.org/10.5935/0103-507x.20210028
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11.
The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA
; BACCARO, FABRICIO
; CRONEMBERGER, CECILIA
; HIPÓLITO, JULIANA
; BARROS, CLAUDIA FRANCA
; RODRIGUES, DOMINGOS DE JESUS
; NECKEL-OLIVEIRA, SELVINO
; OVERBECK, GERHARD E.
; DRECHSLER-SANTOS, ELISANDRO RICARDO
; ANJOS, MARCELO RODRIGUES DOS
; FERREGUETTI, ÁTILLA C.
; AKAMA, ALBERTO
; MARTINS, MARLÚCIA BONIFÁCIO
; TOMAS, WALFRIDO MORAES
; SANTOS, SANDRA APARECIDA
; FERREIRA, VANDA LÚCIA
; CUNHA, CATIA NUNES DA
; PENHA, JERRY
; PINHO, JOÃO BATISTA DE
; SALIS, SUZANA MARIA
; DORIA, CAROLINA RODRIGUES DA COSTA
; PILLAR, VALÉRIO D.
; PODGAISKI, LUCIANA R.
; MENIN, MARCELO
; BÍGIO, NARCÍSIO COSTA
; ARAGÓN, SUSAN
; MANZATTO, ANGELO GILBERTO
; VÉLEZ-MARTIN, EDUARDO
; SILVA, ANA CAROLINA BORGES LINS E
; IZZO, THIAGO JUNQUEIRA
; MORTATI, AMANDA FREDERICO
; GIACOMIN, LEANDRO LACERDA
; ALMEIDA, THAÍS ELIAS
; ANDRÉ, THIAGO
; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA
; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA
; MESSIAS, MARILUCE REZENDE
; MARQUES, MARCIA C.M.
; PADIAL, ANDRE ANDRIAN
; MARQUES, RENATO
; BITAR, YOUSZEF O.C.
; SILVEIRA, MARCOS
; MORATO, ELDER FERREIRA
; PAGOTTO, RUBIANI DE CÁSSIA
; STRUSSMANN, CHRISTINE
; MACHADO, RICARDO BOMFIM
; AGUIAR, LUDMILLA MOURA DE SOUZA
; FERNANDES, GERALDO WILSON
; OKI, YUMI
; NOVAIS, SAMUEL
; FERREIRA, GUILHERME BRAGA
; BARBOSA, FLÁVIA RODRIGUES
; OCHOA, ANA C.
; MANGIONE, ANTONIO M.
; GATICA, AILIN
; CARRIZO, MARÍA CELINA
; RETTA, LUCÍA MARTINEZ
; JOFRÉ, LAURA E.
; CASTILLO, LUCIANA L.
; NEME, ANDREA M.
; RUEDA, CARLA
; TOLEDO, JOSÉ JULIO DE
; GRELLE, CARLOS EDUARDO VIVEIROS
; VALE, MARIANA M.
; VIEIRA, MARCUS VINICIUS
; CERQUEIRA, RUI
; HIGASHIKAWA, EMÍLIO MANABU
; MENDONÇA, FERNANDO PEREIRA DE
; GUERREIRO, QUÊZIA LEANDRO DE MOURA
; BANHOS, AUREO
; HERO, JEAN-MARC
; KOBLITZ, RODRIGO
; COLLEVATTI, ROSANE GARCIA
; SILVEIRA, LUÍS FÁBIO
; VASCONCELOS, HERALDO L.
; VIEIRA, CECÍLIA RODRIGUES
; COLLI, GUARINO RINALDI
; CECHIN, SONIA ZANINI
; SANTOS, TIAGO GOMES DOS
; FONTANA, CARLA S.
; JARENKOW, JOÃO A.
; MALABARBA, LUIZ R.
; RUEDA, MARTA P.
; ARAUJO, PUBLIO A.
; PALOMO, LUCAS
; ITURRE, MARTA C.
; BERGALLO, HELENA GODOY
; MAGNUSSON, WILLIAM E.
.
Anais da Academia Brasileira de Ciências
- Métricas do periódico
Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.
https://doi.org/10.1590/0001-3765202120201604
1034 downloads
12.
Antifungal activity and mechanism of action of 2-chloro-N -phenylacetamide: a new molecule with activity against strains of Aspergillus flavus
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FERREIRA, ELBA S.
; CORDEIRO, LAÍSA V.
; SILVA, DANIELE DE F.
; SOUZA, HELIVALDO D.S.
; ATHAYDE-FILHO, PETRÔNIO F. DE
; BARBOSA-FILHO, JOSÉ MARIA
; SCOTTI, LUCIANA
; LIMA, EDELTRUDES O.
; CASTRO, RICARDO D. DE
.
Abstract Aspergillus genus causes many diseases, and the species Aspergillus flavus is highly virulent. Treatment of aspergillosis involves azole derivatives such as voriconazole and polyenes such as amphotericin B. Due to an increase in fungal resistance, treatments are now less effective; the search for new compounds with promising antifungal activity has gained importance. The aims of this study were to evaluate the effects of the synthetic amide 2-chloro-N-phenylacetamide (A1Cl) against strains of Aspergillus flavus and to elucidate its mechanism of action. Thus, the minimum inhibitory concentration, minimum fungicidal concentration, conidial germination, associations with antifungal agents, cell wall activities, membrane activities and molecular docking were evaluated. A1Cl presented antifungal activity against Aspergillus flavus strains with a minimum inhibitory concentration of between 16 and 256 μg/mL and a minimum fungicidal concentration between 32 and 512 μg/mL. The minimum inhibitory concentration of A1Cl also inhibited conidial germination, but when associated with amphotericin B and voriconazole, it promoted antagonistic effects. Binding to ergosterol on the fungal plasma membrane is the likely mechanism of action, along with possible inhibition of DNA synthesis through the inhibition of thymidylate synthase. It is concluded that the amide 2-chloro-N-phenylacetamide has promising antifungal potential.
https://doi.org/10.1590/0001-3765202120200997
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13.
Growth Kinetics of β´Precipitation in a Ferritic Matrix During Isothermal Aging of Cu-containing Fe-10at.%Ni-15at.%Al alloys
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Dorantes-Rosales, Hector J.
; Ferreira-Palma, Carlos
; Lopez-Hirata, Victor M.
; Saucedo-Muñoz, Maribel L.
; Avila-Davila, Erika O.
; Hernandez-Santiago, Felipe
; Villegas-Cárdenas, José D.
; Rivas-Lopez, Diego
.
Abstract A precipitation study was carried out during the isothermal aging at 850 °C for Fe-10at.%Ni-15at.%Al, Fe-10at.%Ni-15at.%Al-2.5at.%Cu and Fe-10at.%Ni-15at.%Al-5at.%Cu alloys. The experimental, Calphad, and Kinetic/Precipitation calculated results indicated that the Cu-addition to the ternary alloy promoted a higher volume fraction of β´precipitates, which caused a better aging response for the Cu-containing alloys. The coarsening resistance was the highest for the 2.5 at. % Cu-containing alloy, compared to the ternary alloy because of its lower interfacial free energy, 0.009 Jm-2, between the precipitate and the matrix. The Cu alloying element was located mainly in the β´ precipitate according to its expected thermodynamic behavior, and it caused an atomic relation of Ni to Al close to that of NiAl intermetallic compound for the β´phase. A content of 5 at. % Cu in the ternary alloy promoted higher interfacial energy, 0.04 Jm-2, and thus the fastest coarsening process.
https://doi.org/10.1590/1980-5373-mr-2021-0232
54 downloads
14.
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.
; Marques, Heloisa H.S.
; Gualano, Bruno
; Lindoso, Livia
; Bain, Vera
; Astley, Camilla
; Martins, Fernanda
; Matheus, Denise
; Matsuo, Olivia M.
; Suguita, Priscila
; Trindade, Vitor
; Paula, Camila S.Y.
; Farhat, Sylvia C.L.
; Palmeira, Patricia
; Leal, Gabriela N.
; Suzuki, Lisa
; Odone Filho, Vicente
; Carneiro-Sampaio, Magda
; Duarte, Alberto José S.
; Antonangelo, Leila
; Batisttella, Linamara R.
; Polanczyk, Guilherme V.
; Pereira, Rosa Maria R.
; Carvalho, Carlos Roberto R.
; Buchpiguel, Carlos A.
; Latronico, Ana Claudia
; Seelaender, Marilia
; Silva, Clovis Artur
; Pereira, Maria Fernanda B.
; Sallum, Adriana M. E.
; Brentani, Alexandra V. M.
; Neto, Álvaro José S.
; Ihara, Amanda
; Santos, Andrea R.
; Canton, Ana Pinheiro M.
; Watanabe, Andreia
; Santos, Angélica C. dos
; Pastorino, Antonio C.
; Franco, Bernadette D. G. M.
; Caruzo, Bruna
; Ceneviva, Carina
; Martins, Carolina C. M. F.
; Prado, Danilo
; Abellan, Deipara M.
; Benatti, Fabiana B.
; Smaria, Fabiana
; Gonçalves, Fernanda T.
; Penteado, Fernando D.
; Castro, Gabriela S. F. de
; Gonçalves, Guilherme S.
; Roschel, Hamilton
; Disi, Ilana R.
; Marques, Isabela G.
; Castro, Inar A.
; Buscatti, Izabel M.
; Faiad, Jaline Z.
; Fiamoncini, Jarlei
; Rodrigues, Joaquim C.
; Carneiro, Jorge D. A.
; Paz, Jose A.
; Ferreira, Juliana C.
; Ferreira, Juliana C. O.
; Silva, Katia R.
; Bastos, Karina L. M.
; Kozu, Katia
; Cristofani, Lilian M.
; Souza, Lucas V. B.
; Campos, Lucia M. A.
; Silva Filho, Luiz Vicente R. F.
; Sapienza, Marcelo T.
; Lima, Marcos S.
; Garanito, Marlene P.
; Santos, Márcia F. A.
; Dorna, Mayra B.
; Aikawa, Nadia E.
; Litvinov, Nadia
; Sakita, Neusa K.
; Gaiolla, Paula V. V.
; Pasqualucci, Paula
; Toma, Ricardo K.
; Correa-Silva, Simone
; Sieczkowska, Sofia M.
; Imamura, Marta
; Forsait, Silvana
; Santos, Vera A.
; Zheng, Yingying
.
OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.
15.
Adubação fosfatada na produtividade e qualidade de raízes tuberosas de cultivares de mandioca na savana amazônica, Brasil
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Uchôa, Sandra C. P.
; Nascimento, Fernanda R. do
; Alves, José M. A.
; Melo, Valdinar Ferreira
; Silva, Deyse C. O. da
; Silva, Armando J. da
; Batista, Karine D.
; Matos, Kedma da S.
; Albuquerque, José de A. A. de
.
RESUMO A produtividade de mandioca no Brasil, em 2019, foi de 18 t ha-1, muito aquém do seu potencial. O fósforo é um nutriente determinante da produtividade e encontra-se em níveis muito baixos em solos tropicais. Assim, objetivou-se com este trabalho avaliar doses de fósforo na produtividade e qualidade de raízes tuberosas de cultivares de mandioca na savana amazônica. O experimento foi instalado no delineamento experimental de blocos casualizados, em esquema de parcelas subdivididas, com 4 repetições. Nas parcelas foram aleatorizadas cinco doses de fósforo (0, 45, 90, 180 e 360 kg ha-1 de P2O5) e nas subparcelas duas cultivares de mandioca (Aciolina e Amazonas). Aos 12 meses de cultivo, as raízes tuberosas foram colhidas e avaliadas. O teor de ácido cianídrico não foi influenciado pelos fatores em estudo. O índice de colheita foi dependente, apenas, das cultivares, sendo superior na cv. Amazonas. A cv. Amazonas foi mais produtiva (86 t ha-1), porém, menos eficiente na utilização do P. A produtividade das cultivares Aciolina e Amazonas foram incrementadas em 125 e 82%, até as doses de máxima eficiência técnica de 192 e 208 kg ha-1 de P2O5, respectivamente. Portanto, a adubação fosfatada é uma boa opção para o cultivo da mandioca.
ABSTRACT In 2019, cassava productivity in Brazil was 18 t ha-1, well below its potential. Phosphorus is a nutrient that determines productivity and is found at very low levels in tropical soils. Thus, the objective of this work was to evaluate phosphorus doses in the yield and quality of tuberous roots of cassava cultivars in the Amazonian savanna. The experiment was installed in a randomized block design, in a split-plot scheme, with 4 replications. In the plots, five doses of phosphorus were randomized: 0, 45, 90, 180 and 360 kg ha-1 de P2O5 and in the subplots two cultivars (Aciolina and Amazonas). At 12 months the plants were harvested and the effect of treatments was evaluated. The HCN content was not influenced by the factors under study. The CI was dependent only on the cultivars, being higher in cv. Amazonas. The cv. Amazonas was more productive (86 t ha-1), but less efficient in the use of P. The productivity of the cultivars Aciolina and Amazonas were increased by 125 and 82%, up to the doses of maximum technical efficiency of 192 and 208 kg ha-1 de P2O5, respectively. Therefore, phosphate fertilization is a good option for the cultivation of cassava.
https://doi.org/10.19084/rca.20746
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