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Abstract Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics.

https://doi.org/10.1016/j.clinsp.2023.100167

Smoking among Brazilian adolescents during the COVID-19 pandemic: a cross-sectional study
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Malta, Deborah Carvalho

; Gomes, Crizian Saar

; Vasconcelos, Nádia Machado de

; Alves, Francielle Thalita Almeida

; Ferreira, Arthur Pate de Souza

; Barros, Marilisa Berti de Azevedo

; Lima, Margareth Guimarães

; Szwarcwald, Celia Landmann

Sao Paulo Medical Journal

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2023, Volume 141 Nº 6 elocation e2022424

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: The social distancing measures during the coronavirus disease 2019 (COVID-19) pandemic resulted in mental suffering among adolescents, leading to risky consumption of psychoactive substances such as tobacco. OBJECTIVE: To analyze the factors associated with tobacco use among adolescents during the COVID-19 social distancing period in Brazil. DESIGN AND SETTING: Cross-sectional study used data from ConVid Adolescentes survey in Brazil. METHODS: Tobacco use was assessed before and during social distancing. The explanatory variables investigated were sex, age, race/skin color, type of school, maternal education, region of residence, adherence to social restriction measures, number of close friends, sleep quality during the pandemic, mood, passive smoking, use of alcoholic beverages during the pandemic, sedentary behavior, and physical activity. A logistic regression model was used for the data analysis. RESULTS: Tobacco use by adolescents did not change during the pandemic (from 2.58% to 2.41%). There was a higher chance of tobacco use among adolescents aged between 16 and 17 years, self-reported black ones, residing in the South and Southeast regions, reported feeling sad and loneliness, had sleeping problems that worsened, were using alcoholic beverages during the pandemic, and were passive smokers at home. Adolescents whose mothers had completed high school or higher, had strict social restrictions, and increased their physical activity during the pandemic had a lower chance of tobacco use. CONCLUSION: Tobacco uses during the COVID-19 pandemic was higher in vulnerable groups, such as black adolescents and those with mental suffering.

https://doi.org/10.1590/1516-3180.2022.0424.r1.30032023

Early reduction of pulmonary arterial hypertension in patients using a long-term mechanical ventricular assistance device: a cross-sectional study
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Rangel, Bruno Soares da Silva

; Biselli, Bruno

; Quintanilha, Nádia Romanelli

; Avila, Mônica Samuel

; Pêgo-Fernandes, Paulo Manuel

; Jatene, Fabio Biscegli

; Kalil Filho, Roberto

; Ferreira, Silvia Moreira Ayub

Sao Paulo Medical Journal

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Jun 2022, Volume 140 Nº 3 Páginas 505 - 508

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Severe pulmonary arterial hypertension (PAH) is a contraindication for heart transplantation (HT). It has been correlated with increased early and late mortality, mainly associated with right ventricular failure. Ventricular assistance devices (VADs) can promote reduction of intracardiac pressures and consequent reduction of PAH over the medium and long terms, thus enabling future candidature for HT. The diminution of early pulmonary pressure within this scenario remains unclear. OBJECTIVE: To evaluate the reduction of PAH and correlate data from right catheterization with the earliness of this reduction. DESIGN AND SETTING: Cross-sectional study in a general hospital in São Paulo, Brazil. METHODS: This was a retrospective analysis on the medical records of patients undergoing VAD implantation in a single hospital. Patients for whom VAD had been indicated as a bridge to candidature for HT due to their condition of constant PAH were selected. RESULTS: Four patients with VADs had constantly severe PAH. Their mean pulmonary artery systolic pressure (PASP) before VAD implantation was 66 mmHg. Over the 30-day period after the procedure, all the patients evolved with a drop in PASP to below 60 mmHg. Their new average was 36 mmHg, which was a drop of close to 50% from baseline values. The one-year survival of this sample was 100%. CONCLUSION: VAD implantation can reduce PAH levels. Early reduction occurred in all patients. Thus, use of VAD is an important bridge tool for enabling candidature for HT among patients with constantly severe PAH.

https://doi.org/10.1590/1516-3180.2021.0944.r2.18032022

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine
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Helito, Alberto C.

; Lindoso, Livia

; Sieczkowska, Sofia M.

; Astley, Camilla

; Queiroz, Ligia B.

; Rose, Natalia

; Santos, Claudia Renata P.

; Bolzan, Thalis

; Peralta, Rita María I.A.

; Franco, Ruth R.

; Cominato, Louise

; Pereira, Rosa Maria R.

; Tannuri, Uenis

; Campos, Lucia Maria A.

; Lourenço, Benito

; Toma, Ricardo K.

; Medeiros, Karina

; Watanabe, Andréia

; Grangeiro, Patricia Moreno

; Farhat, Sylvia C.

; Casella, Caio B.

; Polanczyk, Guilherme V.

; Gualano, Bruno

; Silva, Clovis A.

; Sallum, Adriana M. E.

; Iraha, Amanda Y.

; Ihara, Bianca P.

; Mazzolani, Bruna C.

; Martinez, Claudia A.

; Strabelli, Claudia A. A.

; Fonseca, Claudia B.

; Lima, Dandara C. C.

; Setoue, Debora N. D.

; Roz, Deborah F. P.

; Smaira, Fabiana I.

; Roschel, Hamilton

; Miyatani, Helena T.

; Marques, Isabela G.

; Oba, Jane

; Ferreira, Juliana C. O.

; Simon, Juliana R.

; Kozu, Katia

; Saccani, Ligia P.

; Martiniano, Lorena V. M.

; Miranda, Luana C. A.

; Silva, Luiz E. V.

; Laurentino, Moisés F.

; Aikawa, Nadia E.

; Sakita, Neusa K.

; Tanigava, Nicolas Y.

; Pereira, Paulo R. A.

; Palmeira, Patrícia

; Angelo, Simone S.

; Lavorato, Sofia S. M.

; Bernardes, Tamires M.

; Franco, Tathiane C.

; Viana, Vivianne S. L.

; Barros, Vera P. M. F. R.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3501

Resumo: En | Texto: En | PDF: En

OBJECTIVE: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI). RESULTS: The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001). CONCLUSION: Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

https://doi.org/10.6061/clinics/2021/e3501

O ato fotográfico a partir do olhar
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Anjos, Patrick Werner dos

; Ferreira, Nadiá Paulo

Revista Latinoamericana de Psicopatologia Fundamental

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Dez 2020, Volume 23 Nº 4 Páginas 857 - 876

O nosso objetivo é articular a fotografia com a diferença que Jacques Lacan apresenta, no Seminário 11. Os quatros conceitos fundamentais da psicanálise, entre o olho, o olhar e ser olhado. Dessa articulação nascem as questões: Até que ponto podemos confiar no caráter de evidência fidedigna da realidade na fotografia? Em um mundo dominado pelas imagens, qual o efeito que a fotografia provoca em nós como espectadores?

This article relates photography to the difference that Jacques Lacan presents in Reading Seminar XI: Lacan’s Four Fundamental Concepts of Psychoanalysis, between the eye, the gaze and being-looked-at. This exercise raises the following questions: To what extent may we rely on the character of reliable evidence of reality in photography? In a world dominated by images, what effect does photography have on us, spectators?

Nuestro objetivo es articular la fotografía con la distinción que Jacques Lacan presenta, en El Seminario. Libro 11: los cuatro conceptos fundamentales del psicoanálisis, entre el ojo, la mirada y el ser mirado. De esta articulación nacen las cuestiones: ¿Hasta qué punto podemos confiar en el carácter de evidencia fidedigna de la realidad en la fotografía? En un mundo dominado por las imágenes, ¿cuál es el efecto que la fotografía nos provoca como espectadores?

Notre objectif est d’associer la photographie à la différence que Jacques Lacan présente dans Le séminaire, livre 11: les quatre concepts fondamentaux de la psychanalyse, entre l’œil, le regard et être regardé. De cette association découlent les questions suivantes: dans quelle mesure pouvons-nous nous fier au caractère évident et fiable de la réalité en photographie? Dans un monde dominé par les images, quel est l’effet de la photographie sur nous, les spectateurs?

https://doi.org/10.1590/1415-4714.2020v23n4p857.11 683 downloads

Expression and antigenic analysis of the recombinant TRP36 protein from Ehrlichia canis São Paulo strain for serologic tests
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Medeiros, Miguel Ângelo da Silva

; Silva, Maria Helena da

; Matta, Maria Adelaide do Valle

; Ferreira, Eliane de Oliveira

; Machado, Sérgio Lisboa

; Soares, João Fábio

; Labruna, Marcelo Bahia

; Toma, Helena Keiko

; Xavier, Márcia de Souza

; Meirelles, Maria de Nazareth Silveira Leal de

; Almosny, Nádia Regina Pereira

Revista Brasileira de Parasitologia Veterinária

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2020, Volume 29 Nº 3 elocation e005820

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Ehrlichia canis é o principal agente etiológico da erliquiose monocítica canina (EMC), uma doença infecciosa canina globalmente dispersa. No Brasil, a EMC é considerada endêmica, e a infecção pode atingir 65% em cães em alguns estados. O diagnóstico de erliquiose é importante para fins de tratamento e epidemiológicos. A proteína TRP36 de E. canis leva a uma resposta humoral com produção de anticorpos em fase aguda, encontrada durante o curso da doença. O objetivo deste estudo foi obter a proteína TRP36 recombinante da amostra São Paulo de E. canis e avaliar seu potencial como ferramenta para o diagnóstico sorológico da CME. O isolado de E. canis São Paulo foi cultivado em células da linhagem DH82 e o DNA genômico foi obtido. O fragmento de DNA bacteriano que codifica toda a ORF de TRP36 foi clonado no vetor pBAD / Thio-TOPO e transformado em células competentes Escherichia coli DH10B, com o plasmídeo portador de trp36 para expressão de proteínas. Para avaliar a antigenicidade da proteína, 16 amostras de soro canino foram previamente analisadas (por PCR e teste sorológico comercial SNAP®4Dx®). Os resultados estavam de acordo com o teste SNAP®4Dx®. Os experimentos que utilizam essa proteína recombinante como antígeno, visando ao desenvolvimento de um teste sorológico baseado no ELISA, são o próximo passo para produzir um teste de diagnóstico confiável, acessível e útil para o diagnóstico da EMC no Brasil.

Abstract Ehrlichia canis is the main etiological agent of canine monocytic ehrlichiosis (CME), a globally canine infectious disease. In Brazil, CME is considered to be endemic, and its prevalence can reach 65% in some states. The diagnosis of ehrlichiosis is important for treatment and epidemiological purposes. The E. canis TRP36 (Tandem Repeat Protein) protein elicits the earliest acute-phase antibody response observed during the course of the disease. This study aimed to generate the recombinant TRP36 protein from E. canis São Paulo strain and to evaluate its potential as a tool for the serologic diagnosis of CME. The E. canis São Paulo isolate was cultivated in DH82 lineage cells, and its genomic DNA was obtained. The bacterial DNA fragment encoding the entire ORF of TRP36 was cloned into the pBAD/Thio-TOPO vector and transformed into Escherichia coli DH10B competent cells with the trp36-bearing plasmid for protein expression. To evaluate the protein antigenicity, 16 canine serum samples were previously tested (by PCR and the commercial SNAP®4Dx® serological test). The results were in accordance with the SNAP®4Dx® test. Experiments using this recombinant protein as an antigen, targeting the development of a serologic test based on ELISA methodology, are the next step to produce a reliable, affordable and useful diagnostic tool for CME in Brazil.

https://doi.org/10.1590/s1984-29612020051 900 downloads

Evaluation of comprehensive care for older adults in primary care services
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Placideli, Nádia

; Castanheira, Elen Rose Lodeiro

; Dias, Adriano

; Silva, Pedro Alcântara da

; Carrapato, Josiane Lozigia Fernandes

; Sanine, Patricia Rodrigues

; Machado, Dinair Ferreira

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Nunes, Luceime Olivia

; Monti, José Fernando Casquel

; Hartz, Zulmira Maria de Araújo

; Nemes, Maria Ines Battistella

Revista de Saúde Pública

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2020, Volume 54 elocation 06

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Avaliar o desempenho da atenção integral ao idoso em serviços de atenção primária do Sistema Único de Saúde no estado de São Paulo, Brasi lMÉTODOS Um total de 157 serviços de atenção primária de cinco regiões de saúde do centro-oeste paulista respondeu, de outubro a dezembro de 2014, o instrumento pré-validado Questionário de Avaliação e Monitoramento de Serviços de Atenção Básica 2014. Foram selecionadas 155 questões, com base nas políticas e diretrizes nacionais sobre essa temática. As respostas indicam o desempenho do serviço na atenção ao idoso, agrupadas em três domínios de análise: atenção à saúde para o envelhecimento ativo e saudável (45 indicadores, d1), atenção às doenças crônicas não transmissíveis (89 indicadores, d2) e rede de apoio na atenção ao envelhecimento (21 indicadores, d3). A medida de desempenho foi a soma de respostas positivas (valor 1) ou negativas (valor 0) para cada indicador. Os serviços foram agrupados segundo k-médias dos escores de desempenho de cada um dos domínios. Após a ponderação dos domínios (testes Z), foram estimadas as associações entre os escores de cada domínio e variáveis independentes de gestão (tipologia, planejamento e avaliação dos serviços), por meio de regressão linear simples e múltipla. RESULTADOS A atenção às doenças crônicas não transmissíveis (d2) mostrou, para todos os agrupamentos, melhor desempenho médio (55,7) do que os domínios d1 (35,4) e d3 (39,2). O desempenho do serviço na área geral de planejamento e avaliação esteve associado ao desempenho da atenção ao idoso. CONCLUSÕES Os serviços avaliados apresentaram implementação incipiente da atenção integral ao idoso. O quadro avaliativo pode contribuir para processos de melhoria da qualidade da atenção primária à saúde.

ABSTRACT OBJECTIVE To evaluate the performance of comprehensive care for older adults in primary care services in the Brazilian Unified Health System in the state of São Paulo, Brazil. METHODS A total of 157 primary care services from five health regions in midwestern São Paulo responded, from October to December 2014, the pre-validated 2014 questionnaire for primary care services assessment and monitoring. We selected 155 questions, based on national policies and guidelines on this theme. The responses indicate the service performance in older adults’ care, clustered into three areas of analysis: health care for active and healthy aging (45 indicators, d1), chronic noncommunicable diseases care (89 indicators, d2), and support network in aging care (21 indicators, d3). Performance was measured by the sum of positive (value 1) or negative (value 0) responses for each indicator. Services were clustered according to k-means of the performance scores of each domain. After weighting the domains (Z tests), we estimated the associations between the scores of each domain and independent management variables (typology, planning and evaluation of services), with simple and multiple linear regression. RESULTS Chronic noncommunicable diseases care (d2) showed, for all clusters, better average performance (55.7) than domains d1 (35.4) and d3 (39.2). Service performance in the general area of planning and evaluation associates with the performance of older adults’ care. CONCLUSIONS The evaluated services had incipient implementation of comprehensive care for older adults. The evaluation framework can contribute to processes to improve the quality of primary health care.

https://doi.org/10.11606/s1518-8787.2020054001370 3227 downloads

Evaluation of comprehensive care for older adults in primary care services
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Placideli, Nádia

; Castanheira, Elen Rose Lodeiro

; Dias, Adriano

; Silva, Pedro Alcântara da

; Carrapato, Josiane Lozigia Fernandes

; Sanine, Patricia Rodrigues

; Machado, Dinair Ferreira

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Nunes, Luceime Olivia

; Monti, José Fernando Casquel

; Hartz, Zulmira Maria de Araújo

; Nemes, Maria Ines Battistella

Revista de Saúde Pública

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2020, Volume 54 elocation 06

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2020054001370

Estudio cinético y degradación del Triclosán y Triclocarbán en suelos agrícolas enmendados con compost
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Benítez-Villalba, Julio César

; Dorival-García, Noemí

; Villalba-Villalba, Nadia Mabel

; Ferreira-Benítez, Francisco Paulo

; Rodríguez-Bonet, Sergio

; Vílchez, José Luis

Reportes científicos de la FACEN

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Jun 2019, Volume 10 Nº 1 Páginas 37 - 48

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: In this research work, a kinetic study was performed, degradation of two antimicrobials in soil and compost from sewage sludge and mixture of both matrices. Ultrasound extraction (USE) technique was used to separate the analytes from the matrices involved and were detected and quantified by Ultrapressure Liquid Chromatography (UPLC) coupled to Mass Spectrometry in Tandem (MS/MS, QqQ). The treatment consisted of adding the contaminants manually and irrigating the parcels with well water. Two different soil conditions were fixed: Parcel 1 (P1), soil with pure pollutants applied directly to soil, Plot 2 (P2), soil amended with compost and contaminated with Triclosán (TCS) and Triclocarban (TCB). The degradation kinetics was evaluated in P1 and P2 at different depths (2, 10, 20, 30, 60 cm) along time (0, 15 and 30 days) were observed to be adjusted to an exponential kinetics of first-order (C=Co·e-k.t). In P1, the TCS was retained and degraded on the surface (2 cm) with a half-life (t1/2) 214.6 h, while the TCB was detected in the first 50 cm. In P2 the TCS also disappears completely in this area with a half-life (t1/2) of 146.5 h and as in P2 the TCB leaches up to 50 cm. As a general conclusion, it is observed that half-life times are higher in the experimental conditions of the parcel P1. From the environmental point of view, the amendment of agricultural soils with compost is very beneficial because it provides organic matter, which favors the growth of microorganisms that causes an acceleration in the biodegradation of the studied compounds and preventing their leaching at greater depths.

Resumen: En este trabajo de investigación se realizó un estudio cinético, degradación de dos antimicrobianos en suelo y compost proveniente de lodos de depuradora y mezcla de ambas matrices. Se utilizó la técnica de extracción por ultrasonido (USE) para separar los analitos de las matrices involucradas y fueron detectados y cuantificado mediante Cromatografía de Líquidos de Ultra Presión (UPLC) acoplada a Espectrometría de Masas en Tándem (MS/MS, QqQ). El tratamiento consistió en añadir los contaminantes de forma manual y regarlas parcelas con agua de pozo. Se fijaron dos condiciones diferentes Parcela 1 (P1) suelo con los contaminantes puros aplicados directamente al suelo, Parcela 2 (P2) suelo emendadas con compost y contaminada con Triclosán (TCS) y Triclocarbán (TCB). Se evaluó la cinética de degradación de la P1 y P2 a profundidades (2, 10, 20, 30, 60 cm) a lo largo del tiempo (0, 15 y 30 días), se observó que se ajustaron a una cinética exponencial de primer orden (C=Co·e-k.t). En la P1 el TCS era retenido y degradado en la superficie (2 cm) con un tiempo de vida media(t1/2) 214.6 h, mientras que el TCB se detecta en los primeros 50 cm. En la P2 el TCS también desaparece por completo en esta zona (2 cm) con un (t1/2) de 146.5 h y al igual que en la P2 el TCB lixivia hasta los 50 cm. Como conclusión general, se observa que los tiempos de vida media son mayores en las condiciones experimentales de la parcela P1. Desde el punto de vista medio ambiental el enmendado de los suelos agrícolas con compost es muy beneficioso porque aporta materia orgánica, hecho que favorece el crecimiento de microorganismos que provoca una aceleración en la biodegradación de los compuestos estudiados e impidiendo su lixiviación a mayores profundidades.

https://doi.org/10.18004/rcfacen.2019.10.1.37 168 downloads

10.

Lower genital tract infections in young female juvenile idiopathic arthritis patients
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Ferreira, Gabriela R. V.

; Tomioka, Renato B.

; Queiroz, Ligia B.

; Kozu, Katia

; Aikawa, Nadia E.

; Sallum, Adriana M. E.

; Serafini, Paulo

; Tacla, Maricy

; Baracat, Edmund C.

; Pereira, Rosa M. R.

; Bonfá, Eloisa

; Silva, Clovis A.

Advances in Rheumatology

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2019, Volume 59 elocation 50

Resumo: En | Texto: En | PDF: En

Abstract Background: To evaluate human papillomavirus (HPV), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in juvenile idiopathic arthritis (JIA) patients. Methods: After exclusion, 33 female adolescent and young JIA patients (ILAR criteria) and 28 healthy controls were selected for this study. Demographic data, gynecological, sexual function, cervical cytology and histological abnormalities were evaluated. JIA clinical/laboratorial parameters and treatment were also assessed. HPV-DNA, CT-DNA and NG-DNA testing in cervical specimens were performed by Hybrid Capture 2 assays. Results: The mean current age was similar in JIA patients and controls (23.3 ± 6.24 vs. 26.1 ± 6.03 years, p = 0.09). The frequencies of sexual intercourse (76% vs. 89%, p = 0.201) and abnormal cervical cytology (24% vs. 11%, p = 0.201) were similar in JIA compared to controls. The higher frequency of HPV infection in JIA patients than controls (30% vs. 11%, p = 0.155) did not reach statistical significance. CT (0% vs. 7%, p = 0.207) and NG infections (0% vs. 4%, p = 0.459) were also alike in both groups. Further evaluation of JIA patients with abnormal and normal cervical cytology showed that the former group had a higher frequency of HPV infection (87% vs. 12%, p = 0.0002) with a low frequency of HPV vaccination (0% vs. 8%, p = 1.0). No differences were evidenced between these two JIA groups regarding demographic data, sexual function and clinical/laboratorial parameters. The frequencies of methotrexate (p =0.206) and biological agent use (p =0.238) were similar in both JIA groups. Conclusions: To our knowledge, this was the first study to assess lower genital infections in JIA patients allowing the identification of HPV as main cause of cervical dysplasia. Methotrexate and biological agents do not seem to increase risk of lower genital tract infections in JIA patients.

https://doi.org/10.1186/s42358-019-0092-6 407 downloads

11.

Sexual function in female juvenile idiopathic arthritis patients
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Pitta, Ana Claudia

; Ferreira, Gabriela Ribeiro Viola

; Tomioka, Renato Bussadori

; Lourenço, Daniela Mencaroni Rodrigues

; Kozu, Katia

; Aikawa, Nadia Emi

; Sallum, Adriana Maluf Elias

; Campos, Lucia Maria Arruda

; Abdo, Carmita Helena Najjar

; Pereira, Rosa Maria Rodrigues

; Baracat, Edmund Chada

; Bonfá, Eloisa

; Silva, Clovis Artur

Advances in Rheumatology

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2019, Volume 59 elocation 13

Resumo: En | Texto: En | PDF: En

Abstract Objective: To evaluate sexual function female adolescents and young adults with juvenile idiopathic arthritis (JIA) and healthy controls. Methods: After exclusion, 21 female adolescent and young JIA patients and 25 healthy controls were selected for this study. Sexual function was assessed by the Sexual Quotient Questionnaire for Females (SQQ-F) score, which is a validated tool and adapted for Brazilian Portuguese language. Demographic data, JIA clinical/laboratory parameters and treatment were also assessed. Results: The median current age [26.5 (17-38.1) vs. 29.3 (19.7-35.8) years, p = 0.700)] as well as age at the first sexual activity [18 (14-30) vs. 17 (10-24) years, p = 0.158] were similar in JIA patients and healthy controls. The median of SQQ-F score was alike in both groups [75.9 (50-92) vs. 78.2 (58-94), p = 0.529], as well as frequencies of sexual dysfunction (14% vs. 12%, p = 1.000). The frequencies of all sexual domains (desire/sexual fantasies, desire/interest, arousal/foreplay, arousal/lubrication, arousal/in tune with partner, penetration/relaxation, pain/penetration, desire/involvement, orgasm and general satisfaction scores) were similar in JIA patients and healthy controls (p > 0.05). Conclusions: To our knowledge, this was the first study using a validated sexual score in a chronic arthritis population suggesting a low frequency of overall sexual dysfunction in young JIA patients. Future multicenter studies with a large sample will be necessary to confirm this finding.

https://doi.org/10.1186/s42358-019-0058-8 532 downloads

12.

Autoimmune hepatitis in 847 childhoodonset systemic lupus erythematosus population: a multicentric cohort study
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Balbi, Verena A.

; Montenegro, Bárbara

; Pitta, Ana C.

; Schmidt, Ana R.

; Farhat, Sylvia C.

; Coelho, Laila P.

; Ferreira, Juliana C. O.

; Pereira, Rosa M. R.

; Terreri, Maria T.

; Saad-Magalhães, Claudia

; Aikawa, Nadia E.

; Sakamoto, Ana P.

; Kozu, Kátia

; Campos, Lucia M.

; Sallum, Adriana M.

; Ferriani, Virginia P.

; Piotto, Daniela P.

; Bonfá, Eloisa

; Silva, Clovis A.

Advances in Rheumatology

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2018, Volume 58 elocation 43

Resumo: En | Texto: En | PDF: En

Abstract Objective: To evaluate autoimmune hepatitis (AIH) in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. Methods: This retrospective multicenter study included 847 patients with cSLE, performed in 10 Pediatric Rheumatology services of São Paulo state, Brazil. AIH was defined according to the International Autoimmune Hepatitis Group criteria (IAHGC). The statistical analysis was performed using the Bonferroni's correction (p < 0.0033). Results: AIH in cSLE patients confirmed by biopsy was observed in 7/847 (0.8%) and all were diagnosed during adolescence. The majority occurred before or at cSLE diagnosis [5/7 (71%)]. Antinuclear antibodies were a universal finding, 43% had concomitantly anti-smooth muscle antibodies and all were seronegative for anti-liver kidney microsomal antibodies. All patients with follow-up ≥18 months (4/7) had complete response to therapy according to IAHGC. None had severe hepatic manifestations such as hepatic failure, portal hypertension and cirrhosis at presentation or follow-up. Further comparison of 7 cSLE patients with AIH and 28 without this complication with same disease duration [0 (0–8.5) vs. 0.12 (0–8.5) years, p = 0.06] revealed that the frequency of hepatomegaly was significantly higher in cSLE patients in the former group (71% vs. 11%, p = 0.003) with a similar median SLEDAI-2 K score [6 (0–26) vs. 7 (0–41), p = 0.755]. No differences were evidenced regarding constitutional involvement, splenomegaly, serositis, musculoskeletal, neuropsychiatric and renal involvements, and treatments in cSLE patients with and without AIH (p > 0.0033). Conclusions: Overlap of AIH and cSLE was rarely observed in this large multicenter study and hepatomegaly was the distinctive clinical feature of these patients. AIH occurred during adolescence, mainly at the first years of lupus and it was associated with mild liver manifestations.

https://doi.org/10.1186/s42358-018-0043-7 473 downloads

13.

Maternal socioeconomic factors and adverse perinatal outcomes in two birth cohorts, 1997/98 and 2010, in São Luís, Brazil
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Cavalcante, Nádia Carenina Nunes

; Simões, Vanda Maria Ferreira

; Ribeiro, Marizélia Rodrigues Costa

; Lamy-Filho, Fernando

; Barbieri, Marco Antonio

; Bettiol, Heloisa

; Silva, Antônio Augusto Moura da

Revista Brasileira de Epidemiologia

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Dez 2017, Volume 20 Nº 4 Páginas 676 - 687

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Vários estudos mostram desigualdades sociais no baixo peso ao nascer (BPN), nascimento pré-termo (NPT) e restrição do crescimento intrauterino (RCIU), que nos últimos anos diminuíram ou desapareceram em determinados locais. Objetivos: Estimar as taxas de BPN, NPT e RCIU em São Luís, Maranhão, Brasil, em 2010, e verificar as associações entre fatores socioeconômicos e esses indicadores. Métodos: Este estudo baseia-se em uma coorte de nascimentos realizada em São Luís. Incluiu 5.051 nascimentos únicos hospitalares em 2010. O teste do qui-quadrado foi utilizado para comparação de proporções, enquanto modelos de regressão de Poisson simples e múltipla com variância robusta foram usados para estimar riscos relativos. Resultados: As taxas de BPN, NPT e RCIU foram de 7,5, 12,2 e 10,3%, respectivamente. O BPN foi maior em famílias de baixa renda, enquanto NPT e RCIU não estiveram associados com fatores socioeconômicos. Conclusão: A ausência ou associação fraca desses indicadores com desigualdades sociais aponta para melhorias na atenção à saúde e/ou em condições sociais em São Luís.

ABSTRACT: Several studies have identified social inequalities in low birth weight (LBW), preterm birth (PTB), and intrauterine growth restriction (IUGR), which, in recent years, have diminished or disappeared in certain locations. Objectives: Estimate the LBW, PTB, and IUGR rates in São Luís, Maranhão, Brazil, in 2010, and check for associations between socioeconomic factors and these indicators. Methods: This study is based on a birth cohort performed in São Luís. It included 5,051 singleton hospital births in 2010. The chi-square test was used for proportion comparisons, while simple and multiple Poisson regression models with robust error variance were used to estimate relative risks. Results: LBW, PTB and IUGR rates were 7.5, 12.2, and 10.3% respectively. LBW was higher in low-income families, while PTB and IUGR were not associated with socioeconomic factors. Conclusion: The absence or weak association of these indicators with social inequality point to improvements in health care and/or in social conditions in São Luís.

https://doi.org/10.1590/1980-5497201700040010 74 downloads

14.

Maternal socioeconomic factors and adverse perinatal outcomes in two birth cohorts, 1997/98 and 2010, in São Luís, Brazil
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Cavalcante, Nádia Carenina Nunes

; Simões, Vanda Maria Ferreira

; Ribeiro, Marizélia Rodrigues Costa

; Lamy-Filho, Fernando

; Barbieri, Marco Antonio

; Bettiol, Heloisa

; Silva, Antônio Augusto Moura da

Revista Brasileira de Epidemiologia

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Dez 2017, Volume 20 Nº 4 Páginas 676 - 687

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-5497201700040010 990 downloads

15.

Padre António Vieira: o discurso engenhoso em nome da fé e da salvação do homem
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Ferreira, Nadiá Paulo

Revista Latinoamericana de Psicopatologia Fundamental

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Set 2016, Volume 19 Nº 3 Páginas 544 - 554

Au XVIIe siècle, le sermon est le moyen d’évangélisation de l´église catholique. Baltazar Gracián, le grand théoricien de la rhétorique baroque, élabore les règles du discours ingénieux: un savoir faire avec les mots, un travail de reconstruction de la langue. Dans ses sermons, le Père António Vieira utilise l’ingénieux au service d’un discours qui s’inscrit dans l’une des versions mythiques du Portugal: une nation dont le peuple attend avec la résurrection de Dom Sebastião, roi mort dans la bataille de Alkácer Kibir, la reconquête du passé glorieux de l´époque des grandes découvertes.

In the seventeenth century, the sermon is the path to the evangelization of Catholicism. Baltazar Gracian, the great theorist of Baroque rhetoric, elaborates the standards for ingenious speech: skill and cleverness with words, a work of reconstruction of language. In his sermons, António Vieira puts ingenuity at the service of a discourse which is inscribed in one of the mythical versions of Portugal: a nation whose people wait to regain the glorious past of the age of Discovery, through the resurrection of Don Sebastian, the king who died in the battle of Alkácer Kibir.

Im siebzehnten Jahrhundert ist die Predigt der Weg der Evangelisierung des Katholizismus. Baltazar Gracian, der große Theoretiker der Barock-Rhetorik, erarbeitet die Regeln für die geschickte Rede: Ein Umgang mit dem Wort, eine Arbeit des Wiederaufbaus der Sprache. In seinen Predigten stellt António Vieira seine Geschicktlichkeit im Dienste seinem paranoiden Delirium, das auf einer der mythischen Versionen von Portugal eingeschrieben ist: eine Nation, deren Menschen mit der Auferstehung von Don Sebastian – König, der in der Schlacht Alkácer Kibir zu Tode kam – die herrliche Vergangenheit im Zeitalter der Entdeckungen zurückerobern wollen.

No século XVII, o sermão é a via da evangelização do catolicismo. Baltazar Gracián, o grande teórico da retórica barroca, elabora as normas do discurso engenhoso: um saber fazer com a palavra, um trabalho de reconstrução da língua. Em seus sermões, padre António Vieira coloca o engenho a serviço de um discurso que se inscreve em uma das versões míticas sobre Portugal: uma nação cujo povo espera com a ressurreição de Dom Sebastião, o rei morto na batalha de Alkácer Kibir, reconquistar o passado glorioso da época dos descobrimentos.

En el siglo XVII, el sermón es la vía de evangelización del catolicismo. Baltazar Gracián, el gran teórico de la retórica barroca, elabora las normas del discurso ingenioso: un saber hacer con la palabra, un trabajo de reconstrucción de la lengua. En sus sermones, padre Antonio Vieira coloca el ingenio a servicio de un discurso el cual se inscribe en una de las versiones míticas sobre Portugal: una nación cuyo pueblo espera, con la resurrección de Don Sebastián, el rey muerto en la batalla de Alkácer Kibir, reconquistar el pasado glorioso de la época de los descubrimientos.

十七世纪，神父的布道是天主教传教，传达上帝福音的渠道。著名学者巴尔塔萨尔﹒格拉希安(BALTAZAR GRACIÁN),巴洛克修辞专家，列举出精巧式布道的一些规则:一是知道选择精巧的词语，一是话语的重新构建。在安东尼奥﹒维埃拉神父的布道词里，对葡萄牙，他采用了精巧的神话般的描述：把葡萄牙描绘成一个等待塞巴斯提安国王复活的民族。塞巴斯提安国王是在北非的阿尔卡瑟﹒基比尔与摩尔人的战斗中阵亡的，可是，战争的目的却是为了恢复葡萄牙在航海大发现时期所建立的荣耀。

https://doi.org/10.1590/1415-4714.2016v19n3p544.12 3766 downloads

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