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Abstract Introduction: Chronic kidney disease is usually asymptomatic, and its diagnosis depends on laboratory tests, with emphasis on serum creatinine and proteinuria. Objective: To assess knowledge on the role of serum creatinine as a biomarker of kidney function in a sample of the Brazilian population. Method: Cross-sectional observational study conducted in São Paulo (SP, Brazil), in which a random adult population was interviewed. Results: A total of 1138 subjects were interviewed, with a median age of 36 years old (27–52); 55.1% were female. Regarding the “creatinine” biomarker, 40.6% stated they had never performed such a test. When asked about their knowledge on the usefulness of this exam, only 19.6% knew its function. The other responses were “I don’t know” (71.6%), evaluating heart function (0.9%) and liver function (7.8%). Of those who reported they had already taken a creatinine test, only 29.4% correctly identified the role of creatinine. When dividing the groups into “knows” and “does not know” the function of creatinine, a statistically significant difference (p < 0.05) was observed regarding level of education, female sex, being a healthcare student/worker, having ever measured creatinine, knowing someone with kidney disease and older age. In the multivariate analysis, the main variable related to knowing the creatinine role was having previously taken the test (OR 5.16; 95% CI 3.16–8.43, p < 0.001). Conclusion: There is a significant lack of knowledge about creatinine and its use in checkups. The results indicate that greater efforts are needed from healthcare professionals to raise awareness on the role of serum creatinine.

Resumo Introdução: A doença renal crônica costuma ser assintomática e seu diagnóstico depende da realização de exames laboratoriais, com destaque para a creatinina sérica e pesquisa de proteinúria. Objetivo: Avaliar em uma amostra da população brasileira o conhecimento sobre o papel da creatinina sérica como marcador de função renal. Método: Estudo observacional transversal realizado na cidade de São Paulo (SP, Brasil), em que foi entrevistada uma população adulta aleatória. Resultados: Foram entrevistados 1138 indivíduos, com idade mediana de 36 anos (27–52); 55,1% do sexo feminino. Com relação ao marcador “creatinina”, 40,6% afirmaram que nunca realizaram tal dosagem. Quando questionados quanto ao conhecimento sobre a utilidade desse exame, somente 19,6% sabiam a sua função. As outras respostas foram “não sei” (71,6%), avaliar o funcionamento do coração (0,9%) e fígado (7,8%). Dos que afirmaram já terem realizado o exame de creatinina, somente 29,4% acertaram a função da creatinina. Ao dividir os grupos em “sabe” e “não sabe” a função da creatinina, percebeu-se diferença estatisticamente significante (p < 0,05) em relação ao grau de escolaridade, sexo feminino, ser aluno/trabalhador da saúde, ter dosado creatinina alguma vez, conhecer alguém com doença renal e maior idade. Na análise multivariada, a principal variável relacionada com conhecer a função da creatinina foi ter realizado o exame anteriormente (OR 5,16; IC 95% 3,16–8,43, p < 0,001). Conclusão: Há grande desconhecimento sobre a creatinina e seu uso em check-ups. Os resultados indicam que é necessário maior esforço por parte dos profissionais de saúde para divulgar o papel da creatinina sérica.

https://doi.org/10.1590/2175-8239-jbn-2023-0117en

Impact of pre-operative weight loss on non-alcoholic fatty liver disease histopathology and insulin resistance in individuals undergoing bariatric surgery: a propensity matched cross-sectional comparison
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Maldonado, Fábio Henrique Ribeiro

; Mega, Paulo Ferreira

; Germano, Carlos Wustemberg

; Dias, Luana Leite Castilho

; Callejas, Guilherme Hoverter

; Gestic, Martinho Antonio

; Utrini, Murillo Pimentel

; Chaim, Felipe David Mendonça

; Callejas-Neto, Francisco

; Chaim, Elinton Adami

; Cazzo, Everton

Sao Paulo Medical Journal

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2024, Volume 142 Nº 1 elocation e2022663

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: The effect of weight loss (WL) on histopathological aspects of non-alcoholic fatty liver disease (NAFLD) may provide further insights into the dynamics of hepatic recovery after WL. OBJECTIVE: To analyze the effects of pre-operative WL on insulin resistance- and NAFLD-related histology in individuals undergoing bariatric surgery (BS) with or without pre-operative WL. DESIGN AND SETTING: A matched cross-sectional study was conducted at a public university hospital and a private clinic in Campinas, Brazil. METHODS: An analytical, observational, cross-sectional study was conducted using prospectively collected databases of individuals who underwent BS and liver biopsy at either a public tertiary university hospital (with pre-operative WL) or a private clinic (without pre-operative WL). Random electronic matching by gender, age, and body mass index (BMI) was performed and two paired groups of 24 individuals each were selected. RESULTS: Of the 48 participants, 75% were female. The mean age was 37.4 ± 9.6. The mean BMI was 38.9 ± 2.6 kg/m2. Fibrosis was the most common histopathological abnormality (91.7%). Glucose was significantly lower in the WL group (92 ± 19.1 versus 111.8 ± 35.4 mg/dL; P = 0.02). Significantly lower frequencies of macrovesicular steatosis (58.3% versus 95.8%; P = 0.004), microvesicular steatosis (12.5% versus 87.5%; P < 0.001), and portal inflammation (50% versus 87.5%; P = 0.011) were observed in the WL group. CONCLUSION: Pre-operative WL was significantly associated with lower frequencies of macro- and mi- crovesicular steatosis, portal inflammation, and lower glycemia, indicating an association between the recent trajectory of body weight and histological aspects of NAFLD.

https://doi.org/10.1590/1516-3180.2022.0663.r1.24042023

Translation, cross-cultural adaptation, and validation of health and self-management in diabetes questionnaire (HASMID-10) into Brazilian Portuguese
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Santos-de-Araújo, Aldair Darlan

; Dibai-Filho, Almir Vieira

; Pontes-Silva, André

; Rêgo, Adriana Sousa

; Santos, Dalyla Lima dos

; Mendes Júnior, Abraão Albino

; Pereira, Fábio Henrique Ferreira

; Bacelar, Solange Negreiros de Almeida

; Oliveira, Bárbara Emanoele Costa

; Tavarez, Rudys Rodolfo de Jesus

; Bassi-Dibai, Daniela

Sao Paulo Medical Journal

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2024, Volume 142 Nº 1 elocation e2022681

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Considering the ability of the health and self-management in diabetes questionnaire (HASMID-10) to verify the impact of self-management on diabetes, we highlight its relevance to scientific research and clinical applicability. However, to date, no study has been conducted to scientifically support its use in other languages. OBJECTIVE: To translate, cross-culturally adapt, and validate the HASMID-10 into the Brazilian Portuguese. DESIGN AND SETTING: A translation, cross-cultural adaptation, and validation study conducted at Ceuma University. METHODS: Study was conducted in accordance with the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and Consensus-based Standards for the Selection of Health Measurement Instruments. We included participants of both sexes diagnosed with diabetes, aged between 18 and 64 years, and without cognitive deficits or any other limitations that would prevent them from answering the questionnaire. We assessed participants using the problem areas in diabetes (PAID) scale and HASMID-10. We assessed reliability using a test-retest model with a 7-day interval between assessments. We used intraclass correlation coefficient (ICC), 95% confidence interval (CI), standard error of measurement (SEM), minimum detectable difference (MDD), Spearman correlation coefficient, and floor and ceiling effects. RESULTS: Sample comprised 116 participants, most of whom were women, overweight, non-practitioners of physical activity, and nonsmokers. We observed significant correlations (P = 0.006; rho = −0.256) between the HASMID-10 and PAID, adequate reliability (ICC = 0.780) and internal consistency (Cronbach's alpha = 0.796). No ceiling or floor effects were observed. CONCLUSION: HASMID-10 has adequate measurement properties and may be used for Brazilians.

https://doi.org/10.1590/1516-3180.2022.0681.r1.10042023

Knowledge and attitudes of rural healthcare providers regarding domestic violence against women: a systematic review
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Nascimento, Cláudio Tarso de Jesus Santos

; Vidigal, Maria Tereza Campos

; Oliveira, Vinícius Henrique Ferreira Pereira de

; Franco, Raquel Porto Alegre Valente

; Vieira, Walbert Andrade

; de-Jesus-Soares, Adriana

; Lima, Rafael Rodrigues

; Franco, Ademir

; Paranhos, Luiz Renato

Sao Paulo Medical Journal

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2024, Volume 142 Nº 3 elocation e2022682

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Specific types of violence such as intimate partner sexual violence and intimate partner homicide occur more frequently in rural areas. OBJECTIVE: This study aimed to systematically review the literature on the knowledge and attitudes of rural healthcare providers regarding cases of domestic violence against women. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia. METHODS: We conducted an electronic search of six databases, which only included observational studies, regardless of the year, language, or country of publication, except for studies that used secondary data and were exclusively qualitative. Two reviewers performed the selection, data extraction, and risk of bias assessment using a specific Joanna Briggs Institute tool. RESULTS: Six studies met the inclusion criteria. All the studies had a low risk of bias. Approximately 38% of these professionals identified injuries caused by violence in patients. When asked about knowing the correct attitude to take in cases of confirmed violence, between 12% and 64% of rural healthcare providers answered positively; most of them would refer to specialized institutions and promote victim empowerment and counseling. The number of professionals with an educational background in the field ranged from 16% to 98%. CONCLUSIONS: The evident disparity across studies shows that some professionals have suboptimal knowledge and require training to adopt the correct attitude when identifying female victims of domestic violence in clinical practice. SYSTEMATIC REVIEW REGISTRATION: This systematic review was registered in the Open Science Framework Database under the registration http://doi.org/10.17605/OSF.IO/B7Q6S.

https://doi.org/10.1590/1516-3180.2022.0682.r1.180723

Radiopacity and physical properties evaluation of infiltrants with Barium and Ytterbium addition
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Pedreira, Priscila Regis

; Damasceno, Janaina Emanuela

; Cerqueira, Gabriela Alves de

; Souza, Ana Ferreira

; Aguiar, Flávio Henrique Baggio

; Marchi, Giselle Maria

Brazilian Dental Journal

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Ago 2023, Volume 34 Nº 4 Páginas 93 - 106

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Radiopaque properties in the infiltrant should be interesting for clinicians to feel more confident to indicate this treatment. Thus, the aim of this study was to evaluate the effect of the incorporation of barium and ytterbium particles on the physical properties of resin infiltrants. Groups were divided according to the addition of ytterbium oxide (Y) alone (30 or 40%) or Y with barium (YB) (15/15% or 20/20% respectively) in the Icon commercial infiltrant and in the experimental infiltrant base. Digital radiography (n=5), Microradiography (n=5), Microtomography (n=3), degree of conversion (n=5), water sorption (n=16), solubility (n=16), contact angle (n=16), flexural strength (n=16), elastic modulus (n=16) and Energy dispersive X-ray Spectroscopy (n=10) were performed. Analyses were performed using the R program, with a significance level of 5%, and microradiography and Microtomography analyses were evaluated qualitatively. In groups with 30 or 40% of ytterbium, radiopacity was higher or equal to enamel. Microradiography and Microtomography appear to have more radiopacity in groups with 40% (Y). Among the groups with no particle addition, those of the experimental infiltrant presented a higher degree of conversion than those of Icon®. In most groups, there was solubility below the ISO-recommended levels. The addition of particles resulted in higher viscosity. Groups with Icon had higher flexural strength and elastic modulus than groups with experimental infiltrant. The addition of 40% (Y) improved polymerization, had low solubility, and had greater radiopacity than enamel, however negatively affected the viscosity increasing then. Experimental groups with the base showed a higher water sorption than Icon groups.

Resumo O objetivo desse estudo foi avaliar o efeito da incorporação de partículas de Bário e Itérbio nas propriedades físicas de infiltrantes resinosos. Os grupos foram divididos de acordo com a adição de Itérbio puro (30 ou 40%) ou Itérbio com Bário (15/15% ou 20/20% respectivamente) no infiltrante comercial Icon e no Infiltrante experimental base. Foram realizados os testes de: radiografia digital (n=5), microradiografia Transversa (n=5), microtomografia (n=3), grau de conversão (n=5), sorção (n=16), solubilidade (n=16), ângulo de contato (n=16), resistência flexural (n=16), modulo de elasticidade (n=16) e Espectroscopia por energia dispersiva (n=10). As análises foram realizadas utilizando o programa R, com nível de significância de 5%, e os testes de microradiografia e microtomografia foram analisados qualitativamente. Nos grupos com 30 ou 40% de Itérbio, a radiopacidade foi maior ou igual ao esmalte dentário. Na microradiografia e microtomografia parece ter maior radiopacidade nos grupos com 40% de itérbio. Dentre os grupos sem adição de partículas, os do infiltrante experimental apresentaram maior grau de conversão do que os do Icon e o grupo controle experimental e com 40% de itérbio apresentaram os melhores resultados. Na maioria dos grupos, a solubilidade foi abaixo dos níveis recomendados pela ISO. A adição de particulas resultou em maior viscosidade. Os grupos com Icon apresentaram maior resistência flexural e modulo de elasticidade do que os grupos com infiltrante experimental e a quantidade de partícula aumentou a resistência e o módulo de elasticidade. A adição de 40% de itérbio melhorou a polimerização, apresentou baixa solubilidade e maior radiopacidade do que o esmalte, porém afetou negativamente a viscosidade, aumentando-a.

https://doi.org/10.1590/0103-6440202305379

[SciELO Preprints] - Nutritional habits, physical activity, body composition, and stress among operational and administrative military police officers
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Jorge, Gabriel de Oliveira Aguiar, Diogo Gerbis Nascimento, Thiago Gomes Brito, Rebeca Lopes da Silva Alves, Paulo Henrique Ferreira Macedo, Francisco Guilherme Lima

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Data de publicação: 2023-06-07

Resumo: En Es Pt

Military police activity is a dangerous, stressful occupation that poses health risks. Nutritional habits, physical activity, body composition and perceived stress, in addition to being interrelated, influence components of professional performance, such as work motivation, general self-efficacy and absenteeism. The objective was to compare nutritional habits, physical activity, body mass index and perceived stress of military police officers working in operational and administrative services, of both sexes, and to investigate the correlation between these variables. The Mann-Whitney U test was used for the comparative analysis and, for the correlational study, the Pearson correlation coefficient. Perceived stress and physical activity were inversely correlated (r=-0.268; p<0.001). Nutritional habits correlated significantly: with physical activity (r=0.381; p<0.001), directly; and, conversely, body mass index (r=0.256; p<0.001) and perceived stress (r=-0.201; p<0.01). Military police officers from the operational service had significantly higher body mass index (U=3695; p<0.001) and physical activity (U=3776; p<0.001) than their counterparts from the administrative service. Men had significantly higher body mass index (U=1333; p<0.001) and physical activity (U=2205; p<0.01) than women, who had significantly higher stress levels than men (U=1927; p<0.001). The correlations and significant differences observed point to the need to implement personnel and health management policies aimed at improving the lifestyle, body composition and stress of military police officers. Study limitations and future directions are discussed.

La actividad de la policía militar es una ocupación peligrosa y estresante que presenta riesgos para la salud. Hábitos alimentarios, actividad física, composición corporal y estrés percibido, además de estar interrelacionados, influyen en componentes del desempeño profesional, como motivación para el trabajo, autoeficacia general y ausentismo. El objetivo fue comparar hábitos nutricionales, actividad física, índice de masa corporal y estrés percibido de policías militares que trabajan en servicios operativos y administrativos, de ambos sexos, e investigar la correlación entre estas variables. Para el análisis comparativo se utilizó la prueba U de Mann-Whitney y, para el estudio correlacional, el coeficiente de correlación de Pearson. Estrés percibido y actividad física se correlacionaron inversamente (r=-0,268; p<0,001). Hábitos nutricionales correlacionaron significativamente: con actividad física (r=0,381; p<0,001), directamente; y, por el contrario, con índice de masa corporal (r=0,256; p<0,001) y estrés percibido (r=-0,201; p<0,01). Los policías militares del servicio operativo presentaron índice de masa corporal (U=3695; p<0,001) y actividad física (U=3776; p<0,001) significativamente mayores que sus homólogos del servicio administrativo. Hombres tenían un índice de masa corporal significativamente mayor (U=1333; p<0,001) y actividad física (U=2205; p<0,01) que las mujeres, quienes tenían niveles de estrés significativamente más altos que los hombres (U=1927; p<0,001). Las correlaciones y diferencias significativas observadas apuntan a necesidad de implementar políticas de gestión de personal y salud dirigidas a mejorar el estilo de vida, composición corporal y estrés de los policías militares. Se discuten limitaciones del estudio y direcciones futuras.

A atividade policial militar é uma ocupação perigosa, estressante e que impõe riscos à saúde. Os hábitos nutricionais, atividade física, composição corporal e estresse percebido, além de relacionarem-se entre si, influenciam componentes do desempenho profissional, tais como motivação para o trabalho, autoeficácia geral e absenteísmo. O objetivo deste estudo foi comparar hábitos nutricionais, atividade física, índice de massa corporal e estresse percebido de policiais militares que atuam no serviço operacional e administrativo, de ambos os sexos, e investigar a correlação entre essas variáveis. Utilizou-se o teste U de Mann-Whitney para a análise comparativa e, para o estudo correlacional, o coeficiente de correlação de Pearson. O estresse percebido e a atividade física correlacionaram-se inversamente (r=-0,268; p<0,001). Os hábitos nutricionais correlacionaram-se significativamente: à atividade física (r=0,381; p<0,001), diretamente; e, inversamente, ao índice de massa corporal (r=0,256; p<0,001) e ao estresse percebido (r=-0,201; p<0,01). Policiais militares do serviço operacional apresentaram índice de massa corporal (U=3695; p<0,001) e atividade física (U=3776; p<0,001) significativamente superiores aos seus congêneres do serviço administrativo. Homens apresentaram índice de massa corporal (U=1333; p<0,001) e atividade física (U=2205; p<0,01) significativamente superiores aos das mulheres, as quais apresentaram níveis de estresse significativamente superiores aos dos homens (U=1927; p<0,001). As correlações e diferenças significativas observadas alertam para a necessidade de implementação de políticas de gestão de pessoal e de saúde voltadas à melhoria do estilo de vida, da composição corporal e do estresse de policiais militares. São discutidas limitações do estudo e direções futuras.

https://doi.org/10.1590/SciELOPreprints.5988

Ribosomal, mitochondrial and bacterial (Wolbachia) reference sequences for Dipetalonema gracile obtained from a wild pied tamarin (Saguinus bicolor) host in Manaus, Brazil
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COSTA, Carlos Henrique Aguiar

; CRAINEY, James Lee

; VICENTE, Ana Carolina Paulo

; CONGA, David Fernandez

; GORDO, Marcelo

; LUZ, Sérgio Luiz Bessa

; DIAS, Cindy Alves

; SILVA, Túllio Romão Ribeiro da

; FERREIRA, Caroline Coelho

; NAVA, Alessandra Ferreira Dales

Acta Amazonica

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Jun 2023, Volume 53 Nº 2 Páginas 130 - 140

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT The primates that inhabit the rainforest surrounding the city of Manaus (Amazonas, Brazil) have long been recognised as potentially important reservoirs of emerging and re-emerging infectious diseases (ERIDs). PCR amplification of filarial sequences from wild-caught Simulium oyapockense has been used to incriminate potentially important Amazon-region ERID bridge vectors by showing they had previously fed on non-human primates. The broader use of filarial parasite sequences for the incrimination of biting insects as potentially important zoonotic disease vectors is limited by a paucity of primate-derived filarial parasite reference sequences which can be matched to the PCR amplified sequences obtained from insect-vector vectors. Here we have used shotgun sequencing to obtain reference data from an adult Dipetalonema gracile parasite which was found infecting a wild pied tamarin (Saguinus bicolor) in a peripheral region of Manaus. We report the parasite´s complete mitochondrial genome (which is 13,647 base pairs in length), 894,846 base pairs of its Wolbachia genome and 6,426 base pairs of its ribosomal DNA locus (spanning from the start of its 18S subunit to the end of its 28S subunit). Despite being critically endangered, S. bicolor is commonly encountered around the periphery of Manaus and in urban forest fragments. The reported sequences may be a useful reference tool for identifying ERID bridge vectors and potentially provide some insights into the amount and the nature of contact between primate pathogen reservoirs and the residents of Manaus.

RESUMO Os primatas que habitam a floresta tropical ao redor da cidade de Manaus (Amazonas, Brasil) há muito são reconhecidos como reservatórios potencialmente importantes de doenças infecciosas emergentes e reemergentes. Sequências de DNA de parasitas filariais detectadas por PCR em amostras de Simulium oyapockense foram usadas para demonstrar que eles haviam se alimentado anteriormente de primatas não humanos e, dessa maneira, incriminar vetores-ponte da região amazônica. O uso mais amplo de detecção de parasitas filariais para a incriminação de vetores-ponte é limitado por uma escassez de sequências referência de parasitas filarias obtidas de hospedeiros. Aqui nós usamos o sequenciamento tipo shotgun para obter dados de referência de um parasita adulto Dipetalonema gracile encontrado infectando um sauim-de-coleira, Saguinus bicolor no entorno de Manaus. Relatamos o genoma mitocondrial completo do parasita (que tem 13.647 pares de bases de comprimento), 894.846 pares de bases de seu genoma de Wolbachia e 6.426 pares de bases de seu locus de DNA ribossômico (desde o início de sua subunidade 18S até o final de sua subunidade 28S). Apesar de criticamente ameaçado, S. bicolor é comumente encontrado no entorno de Manaus e em fragmentos florestais urbanos. As sequências relatadas podem ser uma ferramenta de referência útil para identificar vetores ponte e potencialmente fornecer algumas informações sobre o contato entre reservatórios de patógenos de primatas e os moradores de Manaus.

https://doi.org/10.1590/1809-4392202201741

Association of coffee intake and its polyphenols with mammographic findings in women who visited the Brazilian Public Health Service
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Florencio-de Meneses, Ayana

; de Rezende-Ferreira-Mendes, Ana Luiza

; Rocha, Daianne Cristina

; Alves-de Carvalho-Sampaio, Helena

; Ferreira-Carioca, Antônio Augusto

; Porto-Pinheiro, Luiz Gonzaga

; Diógenes-Vasques, Paulo Henrique

; Nogueira-Bezerra, Ilana

; Teixeira-Cacau, Leandro

Nutrición Hospitalaria

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Abr 2023, Volume 40 Nº 2 Páginas 377 - 383

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: this study aimed to evaluate if there is an association of intake of coffee and its polyphenols with mammographic findings in women treated at a breast care service unit of the Unified Health System (SUS), Brazil. Research methods and procedures: this was a cross-sectional study with 532 women treated at a health service. The participants were divided according to their mammographic reports into two groups: without and with altered findings. Two 24-h dietary recalls were applied and coffee consumption was categorized into three groups (less than 1 cup, 1 to 3 cups, and more than 3 cups). Phenolic acids were determined using the Phenol Explorer program. The intake of polyphenols was calculated by adding the values obtained from the total amount of coffee consumed during the day. The Multiple Source Method (MSM) was applied to analyze the usual intake. Results: of the 532 women, 178 (33.5 %) had altered mammographic findings. The participants' average daily coffee intake was 193.4 mL. No significant association was found between coffee consumption and mammographic findings. However, it was found that the second tertile of polyphenols was a protective factor for breast changes. Conclusion: coffee polyphenols are protective against breast changes in the group evaluated and, thus, can help prevent breast cancer.

Resumen Objetivo: este estudio tuvo como objetivo evaluar si existe una asociación de la ingesta de café y sus polifenoles con los hallazgos mamográficos de mujeres tratadas en una unidad de patología mamaria del Sistema Unificado de Salud (SUS), Brasil. Métodos y procedimientos de investigación: este fue un estudio transversal con 532 mujeres tratadas en un servicio de salud. Las participantes se dividieron de acuerdo con sus informes mamográficos en dos grupos: sin y con hallazgos alterados. Se aplicaron dos registros dietéticos de 24 horas y el consumo de café se clasificó en tres grupos (menos de 1 taza, 1 a 3 tazas y más de 3 tazas). Los ácidos fenólicos se determinaron utilizando el programa Phenol Explorer. La ingesta de polifenoles se calculó sumando los valores obtenidos de la cantidad total de café consumido durante el día. Se aplicó el método de fuentes múltiples (MSM) para analizar la ingesta habitual. Resultados: de las 532 mujeres, 178 (33,5 %) tenían hallazgos mamográficos alterados. La ingesta diaria promedio de café de los participantes fue de 193,4 ml. No se encontró una asociación significativa entre el consumo de café y los hallazgos mamográficos. Sin embargo, se encontró que el segundo tercil de polifenoles era un factor protector para los cambios mamarios. Conclusión: los polifenoles del café son protectores contra los cambios mamarios en el grupo evaluado y, por lo tanto, podrían ayudar a prevenir el cáncer de mama.

https://doi.org/10.20960/nh.04060

Randomized clinical trial to evaluate the effect on postprandial glycemia of Nutren Control®, a glycemia-targeted specialized supplement, compared to standardized breakfast in patients with type-2 diabetes: the CONTROL DIABETES study
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Zagury, Roberto Luis

; Sampaio-Lacativa, Paulo Gustavo

; de Gregório, Luiz Henrique

; Abrahão-Schilling-Rosenfeld, Valéria

; Fuganti-Campos, Leticia

; Calixto-Pinheiro, Renata Alexandra

; Ferreira-da Costa, Samuel

; Tavares-Russo, Luís Augusto

Nutrición Hospitalaria

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Fev 2023, Volume 40 Nº 1 Páginas 41 - 48

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Objetivo: evaluar los efectos de un suplemento especializado en el control de la glucosa (GTSS) frente a un desayuno estándar sobre la glucemia posprandial (PPG). Metodología: es un estudio cruzado, prospectivo, aleatorizado en el que se incluyeron a pacientes con diabetes tipo 2 (T2D) con control subóptimo de la glucemia (HbA1c entre 6,5 y 8,5 %) utilizando monoterapia con metformina. El desayuno estandarizado fue isocalórico en comparación con el GTSS y solamente la distribución calórica fue diferente. Ambas intervenciones se utilizaron una vez al día por la mañana, reemplazando cada una el desayuno durante 7 días consecutivos (14 días de observación). Se utilizó el sistema de monitoreo continuo de glucosa (isCGM) para determinar las diferencias entre las intervenciones con respecto al área bajo la curva (iAUC) de glucosa postprandial (PPG) (3 horas después de la intervención) como variable principal o primaria; las variables secundarias fueron la diferencia entre las intervenciones con respecto al pico glicémico, la excursión de glucosa posprandial (PPGE), la glucosa media en sangre (MBG) y el rango de tiempo (TIR). Resultado: se incluyeron treinta y un pacientes con T2D con edades entre 39 y 69 años. El grupo del GTSS tuvo un área bajo la curva (iAUC) significativamente más baja de la PPG en comparación con el grupo del desayuno estandarizado (33,3 [15,0 a 54,0] frente a 46,8 [27,3 a 75,1] mg/dL), mientras que también presentó una PPG significativamente más baja (26,4 + 17,2 vs. 44,8 + 24,4 mg/dL). No hubo diferencia entre los períodos de intervención con respecto a la MBG, el TIR y eventos hipoglucémicos. Conclusión: el nuevo GTSS, como sustituto del desayuno, produjo una reducción de la iAUC de la PPG del 25 %, según el isCGM, en comparación con un desayuno isocalórico normalizado.

Abstract Objective: to evaluate the effects of a new glycemia targeted specialized supplement (GTSS) compared to a standard breakfast on postprandial blood glucose (PPG). Methods: patients with type 2 diabetes (T2D) and suboptimal control (A1C between 6.5 and 8.5 %) in monotherapy with metformin were included to this prospective, randomized, crossover trial. The standardized breakfast was isoenergetic compared to the GTSS, differing on macronutrients distribution. Both interventions were used once a day in the morning, each replacing breakfast for 7 consecutive days (14 days of observation). Intermittent scanning continuous glucose monitoring system (isCGM) determined the difference between the interventions regarding the incremental area under the curve (iAUC) of the PPG (3 hours after intervention), as a primary endpoint; secondary endpoints were the difference between the interventions regarding the glycemic peak, postprandial glucose excursion (PPGE), mean blood glucose (MBG) and time in range (TIR). Results: thirty-one T2D patients with ages between 39 and 69 years-old were enrolled. GTSS group had significantly lower iAUC of the PPG compared to standardized breakfast (33.3 [15.0 to 54.0] vs 46.8 [27.3 to 75.1] mg/dL), while also presenting a significantly lower PPG excursion (26.4 ± 17.2 vs 44.8 ± 24.4 mg/dL). There was no difference between the intervention periods regarding MBG, TIR and hypoglycemic events. Conclusion: the new GTSS, as a meal replacement in the breakfast, produced a 25 % reduction in the iAUC of the PPG, as accessed by isCGM, in comparison with an isocaloric-standardized meal.

https://doi.org/10.20960/nh.04204

10.

High-throughput phenotyping as an auxiliary tool in the selection of corn hybrids for agronomic traits
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Alcântara, Júlia Ferreira de

; Santos, Regimar Garcia dos

; Baio, Fábio Henrique Rojo

; Silva Júnior, Carlos Antonio da

; Teodoro, Paulo Eduardo

; Teodoro, Larissa Pereira Ribeiro

Revista Ceres

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Jan 2023, Volume 70 Nº 1 Páginas 106 - 113

Resumo: En | Texto: En | PDF: En

ABSTRACT High-throughput phenotyping (HTP) using vegetation indices (VIs) is an important data source for managing plant breeding programs and can be a promising tool in indirect selection. This study hypothesized that VIs are correlated with agronomic traits in corn, and therefore, HTP can be an auxiliary tool for selecting superior genotypes. The objectives were: i) to analyze the association between agronomic traits and VIs, and ii) to identify superior corn hybrids for the evaluated traits using multivariate techniques. Ten corn hybrids (AGRI 330, AGRI 340, FS575PWU, KTZ006VP3, MG545AW, MG580PW, MG711PW, MZ1780, MZ1952, and TROPI 102) were evaluated for plant height (PH), stem diameter (SD), and grain yield (GY). The VIs studied were NDVI, NDRE, EVI, GNDVI, SAVI, and MSAVI. Pearson’s correlation network was constructed to analyze the relationship between the variables, and a canonical analysis was performed to verify the inter-relationship between the variables and hybrids. The VIs evaluated are strongly positively correlated with each other and with PH. The most productive hybrids are MG545AW, FS575PWU and KTZ006VP3. Hybrid MZ1952 has higher correlations with VIs and PH. The findings reveal that VIs can be excellent auxiliary variables for selecting agronomically superior genotypes, being a promising alternative to increase corn breeding efficiency.

https://doi.org/10.1590/0034-737x202370010012

11.

Estado e acumulação de capital na saúde brasileira sob a ótica da Teoria Marxista da Dependência
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Rodrigues, Paulo Henrique de Almeida

; Mattos, Arthur Lobo Costa

; Monteiro, Nercilene Santos da Silva

; Silva, Roberta Dorneles Ferreira da Costa

; Baldo, Valentina Sofía Suárez

Cadernos de Saúde Pública

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2023, Volume 39 Nº 12 elocation e00082923

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract: The health sector is one of the major fields of economic, social, scientific, and technological development in Brazil, and has been the arena of dispute between capitalist interests that regard health as a commodity and advocates of universal access who regard health as an essential good. The Brazilian Federal Constitution of 1988 determined that health is a fundamental right and the State’s responsibility, and since then the country has made progress with public policy, but has suffered setbacks and blockages due to its status as a peripheric country, historically subordinated to the interests of core countries, which see Brazil as a broad consumer market. These external interests associated with the internal bourgeoisie have been taking advantage of the Brazilian State since the 1960s, when the foundation of business groups expanded, dominating various health segments, especially since the neoliberal policies of the 1990s. These aspects are much explored in publications in Public Health, but this text seeks a new approach, using the Marxist Theory of Dependency as a reference to analyze, albeit in a preliminary way, the situation of political, economic, and technological dependence that has distanced health policy from the ideals of a public and universal system, defended in the Brazilian Health Reform.

Resumen: El sector de la salud es uno de los mayores campos de desarrollo económico, social, científico y tecnológico de Brasil y ha sido un escenario de disputa entre los intereses capitalistas, que entienden la salud como un bien de mercado, y los defensores del acceso universal, que entienden la salud como un bien esencial. En Brasil, la Constitución Federal de 1988 estableció que la salud es un derecho de todos y un deber del Estado, y desde entonces el país ha avanzado con políticas públicas, no exentas de retrocesos y bloqueos debido a la condición de país de periferia económica, históricamente subordinado a los intereses de los países centrales, que ven a Brasil como un amplio mercado consumidor. Estos intereses externos, asociados a la burguesía interna, han obtenido ventajas del Estado brasileño desde la década de 1960, cuando se expandió la formación de grupos empresariales, dominando varios segmentos de la salud, sobre todo a partir de políticas neoliberales de la década de 1990. Estos aspectos son ampliamente explorados en publicaciones del campo de la Salud Colectiva, pero este texto busca un nuevo enfoque, utilizando la Teoría Marxista de la Dependencia como referencia para analizar, aunque de forma preliminar, la situación de dependencia política, económica y tecnológica que ha alejado la política de salud de los ideales de un sistema público y universal, defendido en la Reforma Sanitaria brasileña.

Resumo: O setor de saúde constitui um dos maiores campos de desenvolvimento econômico, social, científico e tecnológico do Brasil e tem sido arena de disputa entre os interesses capitalistas, que entendem a saúde como bem de mercado, e os defensores do acesso universal, que a entendem como bem essencial. No Brasil, a Constituição Federal de 1988 determinou que a saúde é direito de todos e dever do Estado, e, desde então, o país avança com a política pública, mas sofre recuos e bloqueios pela condição de país de economia periférica, historicamente subordinado aos interesses dos países centrais, que o veem como um amplo mercado consumidor. Esses interesses externos, associados à burguesia interna, têm obtido vantagens do Estado brasileiro desde a década de 1960, quando a formação de grupos empresariais se expandiu, dominando diversos segmentos da saúde, sobretudo a partir de políticas neoliberais dos anos de 1990. Esses aspectos são muito explorados nas publicações do campo da Saúde Coletiva, mas este texto busca uma nova abordagem, utilizando a Teoria Marxista da Dependência como referência para analisar, ainda que de forma preliminar, a situação de dependência política, econômica e tecnológica que tem distanciado a política de saúde dos ideais de um sistema público e universal, defendido na Reforma Sanitária brasileira.

https://doi.org/10.1590/0102-311xpt082923

12.

Estado e acumulação de capital na saúde brasileira sob a ótica da Teoria Marxista da Dependência
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Rodrigues, Paulo Henrique de Almeida

; Mattos, Arthur Lobo Costa

; Monteiro, Nercilene Santos da Silva

; Silva, Roberta Dorneles Ferreira da Costa

; Baldo, Valentina Sofía Suárez

Cadernos de Saúde Pública

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2023, Volume 39 Nº 12 elocation e00082923

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xpt082923

13.

Accuracy of DRIS and CND methods and nutrient sufficiency ranges for soybean crops in the Northeast of Brazil
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Souza, Henrique Antunes de

; Rozane, Danilo Eduardo

; Vieira, Paulo Fernando de Melo Jorge

; Sagrilo, Edvaldo

; Leite, Luiz Fernando Carvalho

; Brito, Lucélia Cássia Rodrigues de

; Conceição, Mariana Passos

; Ferreira, Ane Caroline Melo

Acta Scientiarum. Agronomy

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2023, Volume 45 elocation e59006

Resumo: En | Texto: En | PDF: En

ABSTRACT. This study aimed to evaluate the nutrition of commercial soybean crops in an agricultural frontier region using the diagnosis and recommendation integrated system (DRIS) and compositional nutrient diagnosis (CND) methods, as well as identify sufficiency ranges. The study was performed by collecting leaf samples (third trifoliate leaf without petiole) at flowering from commercial soybean crops in the states of Piauí and Maranhão, Brazil, and evaluating the crop yield by analyzing macro- and micronutrients in the plant tissue of 98 samples. The DRIS and CND methods were applied based on the cataloged data, followed by the generation of norms, analysis of relationships between yield and nutrients (selecting high-yield crops by the cumulative function of the data), generation of sufficiency ranges, and comparison of methods. The relationships obtained by the DRIS and CND indices with the yield and nutrients were significant, indicating that both methods can be employed for the evaluation of leaf nutrients in soybean. The sufficiency ranges from the DRIS and CND methods presented superior nutrient ranges in relation to the values proposed in the literature for macronutrients, except for nitrogen, and greater range amplitudes for micronutrients.

https://doi.org/10.4025/actasciagron.v45i1.59006

14.

Schistosomiasis of liver graft as a differential diagnosis of abnormal liver tests after transplantation: report of two cases
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Falcão, Lydia Teófilo de Moraes

; Batista, Andrea Dória

; Maranhão, Erika Cavalcante

; Santos, Siglya Soares Ferreira dos

; Madeiro, Vitor Ribeiro Viana

; Moura, Fabio Mesquita

; Lyra, Cesar Henrique Alves

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e2

Resumo: En | Texto: En | PDF: En

ABSTRACT Schistosomiasis is a major health problem that affects over 200 million people worldwide. There are few reports of Schistosoma mansoni found in liver transplants as well as scarce information about the course of the disease and the long-term effects on the graft. Herein, we report two cases of schistosomiasis in liver transplant recipients who presented abnormal serum liver enzymes, with evidence of gradual improvement after antiparasitic treatment. Furthermore, we discuss the possible role of screening the parasite infection in potential liver transplant recipients from endemic areas.

https://doi.org/10.1590/s1678-9946202365002

15.

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023
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Teixeira, Ricardo Alkmim

; Fagundes, Alexsandro Alves

; Baggio Junior, José Mário

; Oliveira, Júlio César de

; Medeiros, Paulo de Tarso Jorge

; Valdigem, Bruno Pereira

; Teno, Luiz Antônio Castilho

; Silva, Rodrigo Tavares

; Melo, Celso Salgado de

; Elias Neto, Jorge

; Moraes Júnior, Antonio Vitor

; Pedrosa, Anisio Alexandre Andrade

; Porto, Fernando Mello

; Brito Júnior, Hélio Lima de

; Souza, Thiago Gonçalves Schroder e

; Mateos, José Carlos Pachón

; Moraes, Luis Gustavo Belo de

; Forno, Alexander Romeno Janner Dal

; D’Avila, Andre Luiz Buchele

; Cavaco, Diogo Alberto de Magalhães

; Kuniyoshi, Ricardo Ryoshim

; Pimentel, Mauricio

; Camanho, Luiz Eduardo Montenegro

; Saad, Eduardo Benchimol

; Zimerman, Leandro Ioschpe

; Oliveira, Eduardo Bartholomay

; Scanavacca, Mauricio Ibrahim

; Martinelli Filho, Martino

; Lima, Carlos Eduardo Batista de

; Peixoto, Giselle de Lima

; Darrieux, Francisco Carlos da Costa

; Duarte, Jussara de Oliveira Pinheiro

; Galvão Filho, Silas dos Santos

; Costa, Eduardo Rodrigues Bento

; Mateo, Enrique Indalécio Pachón

; Melo, Sissy Lara De

; Rodrigues, Thiago da Rocha

; Rocha, Eduardo Arrais

; Hachul, Denise Tessariol

; Lorga Filho, Adalberto Menezes

; Nishioka, Silvana Angelina D’Orio

; Gadelha, Eduardo Barreto

; Costa, Roberto

; Andrade, Veridiana Silva de

; Torres, Gustavo Gomes

; Oliveira Neto, Nestor Rodrigues de

; Lucchese, Fernando Antonio

; Murad, Henrique

; Wanderley Neto, José

; Brofman, Paulo Roberto Slud

; Almeida, Rui M. S.

; Leal, João Carlos Ferreira

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 1 elocation e20220892

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20220892

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