Abstract Over the last few years, comprehensive management programs for the diagnosis and prognosis of alkali-aggregate reaction (AAR) in aging concrete structures were developed in North America, based on a series of laboratory test procedures. Although promising, these lab-procedures presented several parameters whose impacts were not completely understood, which significantly reduced their applicability for the appraisal of deteriorated concrete structures in service. In this context, it has been suggested that two lab-tools, the Stiffness Damage Test (SDT) and the Damage Rating Index (DRI) could reliably assess the condition of concrete affected by AAR. This paper presents the condition assessment of 25, 35 and 45 MPa AAR affected concrete specimens incorporating fine and coarse reactive aggregates and presenting different distress degrees (i.e. expansion levels from 0.05 to 0.30%) through the use of an innovative multi-level approach. Results show that both SDT and DRI are suitable for assessing damage in AAR affected concrete through their output parameters. Yet, they present a complementary character, which illustrates the need for a multi-level approach.

Osteogenesis imperfecta (OI), is a rare condition which is heterogeneous in clinical and genetic terms. Several types have been described and its main feature is bone fragility. It is generally caused by gene mutations in those genes which codify for the α1 and α2 of the type 1 collagen (COL1A1 and COL1A2) with dominant autosomal heredity. We report the case of two relatives (father and daughter) with OI whose genetic study shows a mutation in COL1A1 previously undetected: the deletion of a Guanine, G(c.3524delG). Clinical aspects, heredity and reproductive options of the patients affected are considered.

La osteogénesis imperfecta (OI), es una patología poco frecuente y muy heterogénea desde el punto de vista clínico y genético. Su característica principal es la fragilidad ósea, habiéndose descrito varios tipos. Generalmente es causada por mutaciones en los genes que codifican para las cadenas α1 y α2 del pro-colágeno tipo 1 (COL1A1 y COL1A2) con herencia autosómica dominante. Comunicamos los casos de dos pacientes (padre e hija) con OI cuyo estudio genético muestra una mutación en COL1A1 no conocida previamente: la deleción de una Guanina, G(c.3524delG). Se repasan aspectos clínicos, de herencia y opciones reproductivas de los pacientes afectados.