Pesquisa | SciELO

Resumen La detección de SARS-CoV-2 y su implicancia en el diagnóstico de COVID-19 han sido muy debatidas en la pandemia. El objetivo de este estudio fue evaluar el costo/beneficio de la detección de SARS-CoV-2 en contactos estrechos asintomáticos (CE) mediante el uso de distintas pruebas de diagnóstico molecular. Se estudiaron 51 CE de personas con diagnóstico de SARS-CoV-2 confirmado por RTqPCR, clasificadas por el umbral de ciclos (Ct) (<20, entre 20 y 30 y >30) en hospitales públicos de la provincia de Buenos Aires. Del total de contactos estudiados el 15,7% resultó confirmado para SARS-CoV-2; no hubo contactos positivos de casos con Ct>30. La cantidad de contactos positivos de casos con Ct<20 fue significativamente mayor que la de casos con Ct>20. Las muestras con Ct<20 se asociaron a una carga viral estimada de entre uno a cuatro órdenes de magnitud de diferencia con los rangos de Ct>20. Un 13,7% de contactos positivos fueron casos con Ct<20. De las muestras positivas confirmadas por PCR, correspondientes a la semana epidemiológica 1 de 2021 (SE1), sólo un 19,35% correspondían a muestras con Ct<20 y un 50,7% con Ct entre 20 y 30. Estos datos muestran un incremento de sólo un 3,7% de casos detectados. El esfuerzo por parte del sistema de salud pública para esta estrategia, con bajo poder predictivo, puede tener un efecto negativo para el cumplimiento del aislamiento de los contactos y podría generar una demora en los resultados de los casos sospechosos, sin aportar significativamente en el control de la pandemia.

Abstract The detection of SARS-CoV-2 and its implication in the diagnosis of COVID-19 have been highly debated in the pandemic. The objective of this study was to evaluate the cost/benefit of detecting SARS-CoV-2 in asymptomatic close contacts (CC) using different molecular diagnostic tests. A total of 51 CC of people with a diagnosis of SARS-CoV-2 confirmed by RTqPCR, classified by the cycle threshold (Ct) (<20, between 20 and 30 and >30), were studied in public hospitals in the Province of Buenos Aires. Of the total contacts studied, 15.7% were confirmed for SARS-CoV-2; there were no positive contacts of cases with Ct>30 positive. The number of positive contacts of cases with Ct<20 was significantly higher than that of cases with Ct>20. Samples with Ct<20 were associated with an estimated viral load of one to four orders of magnitude difference with Ct ranges >20. A total of 13.7% of positive close contacts were from cases with Ct<20. When studying positive samples with confirmed diagnosis by PCR, corresponding to 1 epidemiological week of 2021 (EW1), only 19.35% corresponded to samples with Ct<20 and 50.7% with Ct between 20 and 30. From these data it is shown that with the CC test only 3.7% of the cases were detected. The effort by the public health system for this strategy, with low predictive power, may have a negative effect on the fulfillment of the isolation of contacts and could generate a delay in the results of suspected cases, without contributing significantly to controlling the pandemic.

Resumo A detecção do SARS-CoV-2 e seu envolvimento no diagnóstico da COVID-19 têm sido muito discutidos durante a pandemia. O objetivo desse estudo foi avaliar a relação custo/benefício na detecção de SARSCoV- 2 em casos de contatos próximos assintomático (CP), por meio do uso de diferentes testes de diagnóstico molecular. Foram estudados 51 casos de CP de pessoas com diagnóstico de SARS-CoV-2 confirmado pelo RTqPCR, sendo classificados pelo limiar de ciclos (Ct) (<20, entre 20 e 30 e >30), em hospitais públicos da província de Buenos Aires. Do total de contatos estudados, 15,7% foram confirmados para SARS-CoV-2, não houve contatos positivos de casos com Ct>30. O número de contatos positivos de casos com Ct<20, foi significativamente maior que os casos com Ct>20. As amostras com Ct<20 foram associadas a uma carga viral estimada de uma a quatro ordens de magnitude de diferença com os intervalos de Ct>20. Dos casos positivos, 13,7% foram com Ct<20. Das amostras positivas confirmadas por PCR, correspondentes à semana epidemiológica 1 de 2021 (SE1), apenas 19,35% correspondiam a amostras com Ct>20 e 50,7% com Ct entre 20 e 30. Esses dados mostram incremento de apenas 3,7% de casos detectados. O esforço por parte do sistema de saúde pública para essa estratégia, com baixo poder preditivo, pode ter um efeito negativo no cumprimento do isolamento dos contatos e poderia gerar uma demora nos resultados dos casos suspeitos, sem contribuir significativamente para o controle da pandemia.

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Novo curso de philosophia (1840) e sua circulado no Brasil do século XIX
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Silva, Fabiana Sena da

; Neta, Olivia Morais Medeiros

; Farrero, Jordi Garcia

Historia de la educación - anuario

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Jun 2021, Volume 22 Nº 1 Páginas 4 - 10

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este estudo tem como objetivo dar visibilidade ao conteúdo da obra Novo Curso de Philosophia, de Nicolás Eugene Géruzez, publicado em 1833, na Franca, e sua circulando no Brasil. Para tanto, algumas questoes se fizeram necessárias: como e onde esta obra circulou no Brasil do século XIX?, quais as orientanoes de ensino de Filosofia na obra Novo Curso de Philosophia? Para esta análise, tomamos a referida obra nao só como objeto, mas também como fonte de estudos. Como tal - fonte- também faremos uso dos jornais que circularam no Brasil durante a época do Império, período em que a obra foi anunciada. Na busca de pistas da circulando dessa obra, utilizamos o paradigma indiciário, proposto por Cario Ginzburg. O Novo Curso de Philosophia, de Géruzez, circulou no Brasil do século XIX com traduces e publicares diversas, sendo uma das mais difundidas a de Lopes Gama, editada no ano de 1840, em Pernambuco, e com difusdo nas Provincias do Rio de Janeiro, Paraíba, Maranhao, Minas Gerais, Bahia, entre outras. 2 1.

Abstract This study aims to give visibility to the content of the work New Course of Philosophy, by Nicolas Eugenie Géruzez, published in 1833, in France, and its circulation in Brazil. For that, some questions were necessary: how and where did this work circulate in 19th century Brazil?, what are the guidelines for teaching Philosophy in the work New Course of Philosophy? For this analysis, we take the referred work not only as an object, but also as a source of studies. As such -source- we will also make use of the newspapers that circulated in Brazil during the time of the Empire, when the work was announced. In the search for clues to the circulation of this work, we used the indicative paradigm, proposed by Carlo Ginzburg. The New Course of Philosophy, by Géruzez, circulated in Brazil in the 19th century with various translations and publications, one of the most widespread being that of Lopes Gama, published in 1840, in Pernambuco, and with diffusion in the Provinces of Rio de Janeiro, Paraíba, Maranháo, Minas Gerais, Bahia, among others.

Resumen Este estudio tiene por objeto dar visibilidad al contenido de la obra Nuevo Curso de Filosofía, de Nicolás Eugene Géruzez, publicada en 1833, en Francia, y su circulación en el Brasil. Para ello, fueron necesarias algunas preguntas para el análisis: ¿cómo y dónde circuló este trabajo en Brasil en el siglo XIX?, ¿cuáles son las pautas para la enseñanza de la filosofía en el libro Nuevo Curso de Filosofía? Para este análisis, tomamos este trabajo no sólo como un objeto, sino también como una fuente de estudios. Como tal -fuente- también haremos uso de los periódicos que circulaban en Brasil durante la época del imperio, cuando la obra fue anunciada. En la búsqueda de pistas para la circulación de este trabajo, utilizamos el paradigma indicativo propuesto por carlo Ginzburg. El Nuevo Curso de Filosofía de Géruzez circuló en Brasil en el siglo XiX con varias traducciones y publicaciones, siendo una de las más difundidas la de Lopes Gama, publicada en 1840 en Pernambuco, y difundida en las Provincias de Río de Janeiro, Paraíba, Maranhao, Minas Gerais, Bahía, entre otras.

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[SciELO Preprints] - Impact of vaccines against COVID-19 on the incidence of new SARS-COV2 infections in health care workers of the Province of Buenos Aires
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Luzuriaga, Juan Pedro Marsico, Franco Garcia, Enio González, Verónica Kreplak, Nicolás Pifano, Marina González, Soledad

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Data de publicação: 2021-04-01

Resumo: En Es

Introduction. The vaccination plan of the province of Buenos Aires has prioritized the groups with the highest epidemiological risk, initiating the immunization process on Health Care Worker (HCP). The present work aims to evaluate the impact of vaccination on the mean evolution of new SARS-Cov-2 cases in HCP compared to that of the general population. Methodology. Information on confirmed cases was obtained from the Sistema Nacional de Vigilancia en Salud, period April/2020 to March/2021. The number of vaccinated used the base of the VacunatePBA system. Results. As of September, the number of cases begins to decrease more sharply in HCP than in the general population. This trend is consolidated with the beginning of the vaccination plan. By February 2021, 42% of the HCP had been immunized with the first dose and 24% with the second dose. It is observed that, in March, while the number of cases in the General Population increased by 10% compared to February, HCP decreased by 35%. This indicates a significantly more pronounced decrease in HCP (p-value lt;0.00001). Discussion. Since the introduction of the COVID-19 vaccine at the end of december in different countries, a decrease in the incidence of new cases of SARS-CoV-2 infection in HCP has begun to be reported, coinciding with the findings of the present study. Our study provides the first data in the country on the impact of COVID-19 vaccines on HCP.

Introducción. El plan de vacunación de la provincia de Buenos Aires ha priorizado los grupos de mayor riesgo epidemiológico, iniciando el proceso de inmunización sobre el Personal de Salud (PS).El presente trabajo tiene por objetivo evaluar el impacto de la vacunación sobre la evolución media de nuevos casos SARS-Cov-2 en PS comparada con la de la población general. Metodología. La información de los casos confirmados se obtuvo del Sistema Nacional de Vigilancia de la Salud, período abril/2020 a marzo/2021. La cantidad de vacunados utilizó la base del sistema VacunatePBA. Resultados. A partir de septiembre, el número de casos comienza a disminuir más pronunciadamente en PS que en la población general. Esta tendencia se consolida con el comienzo del plan de vacunación. Para febrero de 2021 se han inmunizado con la primera dosis el 42% del PS y con la segunda dosis el 24%. Se observa que, en marzo, mientras la cantidad de casos de la Población General aumenta un 10% respecto a febrero, PS disminuye un 35%. Esto indica un descenso significativamente más pronunciado en PS (p-valor lt; 0.00001). Discusión. A partir de la introducción de la vacuna contra COVID-19 a finales de diciembre en distintos países, se ha comenzado a reportar una baja de la incidencia de nuevos casos de infección por SARS-CoV-2 en PS, coincidente con los hallazgos del presente estudio. Nuestro estudio aporta los primeros datos del país sobre el impacto de las vacunas COVID-19 en PS.

https://doi.org/10.1590/SciELOPreprints.2068

Morphophysiological characterization of Ceratocystis fimbriata isolates from yerba mate
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Brito, Nícolas Manarim de

; Duarte, Henrique da Silva Silveira

; Bühner, Caroline de Bastos

; Auer, Celso Garcia

; Santos, Álvaro Figueredo dos

Ciência Rural

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2021, Volume 51 Nº 3 elocation e20200579

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Este estudo teve como objetivo caracterizar morfologicamente os isolados de Ceratocystis fimbriata e avaliar o efeito do meio de cultura e da temperatura no crescimento micelial e na esporulação de C. fimbriata. Para a caracterização morfológica dos 11 isolados monospóricos do fungo foram preparadas lâminas para determinar as dimensões das estruturas sexuadas e assexuadas do fungo. Quatro experimentos foram conduzidos para avaliar o crescimento micelial e esporulação of C. fimbriata em diferentes meios de culturae temperaturas. Os isolados de C. fimbriata de erva-mate apresentaram peritécios com pescoço de marrom a preto, hifa ostiolar divergente, ascósporos hialinos em formato de chapéu, endoconídios unicelulares, cilíndricos, e aleuroconídios com formato globoso a ovoide. Os meios de cultura PDA e V8-ágar apresentaram os maiores crescimentos miceliais. A temperatura ótima média para crescimento micelial e esporulação dos isolados de C. fimbriata de erva-mate foram de 22,5 e 22,4 ºC, respectivamente.

ABSTRACT: This study aimed to morphologically characterize the isolates of Ceratocystis fimbriata from yerba mate and to evaluate the effect of culture medium and temperature on mycelial growth and sporulation of C. fimbriata. For the morphological characterization of the 11 monosporic isolates of the fungus, slides were prepared to determine the dimensions of the sexual and asexual structures of the fungus. Four experiments were conducted to evaluate the mycelial growth and to evaluate the sporulation of C. fimbriata in different culture mediums and temperatures. The isolates of C. fimbriata from yerba mate showed perithecia with brown to black necks, divergent ostiolar hyphae, hatshaped hyaline ascospores, single-celled, cylindrical endoconidia, and globular to ovoid aleurioconidia. PDA and V8-agar media showed the highest mycelial growth. The average optimum temperature for mycelial growth and sporulation of isolates of C. fimbriata of yerba mate were 22.5 and 22.4 ºC, respectively.

https://doi.org/10.1590/0103-8478cr20200579 535 downloads

Evaluation of salivary protein patterns among a rural population exposed and non-exposed to arsenic-contaminated drinking water in areas of Tucumán (Argentina): a pilot study
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GUBER, Rosa Silvina

; GONZALEZ MAC DONALD, Mauricio

; ALEMAN, Mariano Nicolas

; LUCIARDI, Maria Constanza

; MENTZ, Paula

; WIERNA, Alicia

; ANSONNAUD, Carlos

; GARCIA, Veronica

; ANSONNAUD, Ana María

; SORIA, Analía

Journal of Applied Oral Science

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2021, Volume 29 elocation e20200939

Resumo: En | Texto: En | PDF: En

Abstract Arsenic contamination in the environment and groundwater is a major global public health problem. Several researchers suggest that the toxicity of arsenic could be related to oral cancer development, usually resulting from potentially malignant lesions. During pathological processes, salivary proteins suffer modifications, which could lead to the discovery of new biomarkers. Objective To analyze the protein profile in human saliva samples from a rural population exposed to high levels of arsenic in drinking water and its association with potentially malignant lesions. Methodology This observational, analytic and cross-sectional design included 121 patients from the state of Graneros (Tucumán, Argentina). Arsenic concentration in drinking water was determined and, according to the values obtained, individuals were divided into 2 groups: exposed group and non-exposed group. Saliva samples were obtained, and total protein concentration was measured by Bradford method. Finally, Laemmli SDS-polyacrylamide gel electrophoresis was conducted to obtain the protein profile. Results Total protein concentration in saliva was lower in the exposed group than in the non-exposed group. Average areas of 20 and 42 KDa bands were significantly lower in exposed group than non-exposed group. Conclusion Chronic intake of high arsenic concentrations in drinking water produces changes in the salivary protein profile, which is associated with the presence of potentially malignant lesions.

https://doi.org/10.1590/1678-7757-2020-0939 112 downloads

[SciELO Preprints] - Persistence of antibodies IgG to SARS-CoV2 in health care workers – Province of Buenos Aires
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Pifano, Marina Fischerman, Laura Ercole, Regina Muñoz, Laura Kreplak, Nicolas Garcia, Enio Comes, Yamila Bologna, Rosa

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Data de publicação: 2020-12-30

Resumo: En Es

Aim: To evaluate the persistence of IgG antibodies to SARS-CoV2, in health workers of the public subsector of the Province of Buenos Aires, and correlate it with demographic variables (sex, age) and other health indicators (diagnosis of COVID-19, comorbidities and pregnancy). Methodology: Descriptive, observational, cross-sectional study. Health workers with a positive result in a first sample (N = 388) underwent a second test to evaluate the persistence of antibodies by ELISA. Results: Of the 386 people evaluated with a conclusive result, 296 had a first positive result between 30 and 90 days before the second test, of these, 90% had detectable antibodies. In those with a positive result more than 90 days ago (45), a significant decrease in persistence of 26.7% was observed. There were no significant associations between demographic and health variables and the second test result. Conclusion: Antibodies remain detectable for at least 90 days in 90% of the cases analyzed. It is main to continue this study over time to have a major period of time between tests. The information shown here throws interesting and promising data regarding the possible protection of new COVID-19 infections in personnel with high risk exposure. This evidence could contribute to decision-making, both at the local and regional level, for the adequate vaccination planning, as well as for the management in the event of a possible second wave scenario of COVID-19 pandemic in Latin America.

Objetivo: evaluar la persistencia de los anticuerpos IgG contra SARS-CoV2, en trabajadores de salud del subsector público de la Provincia de Buenos Aires, y correlacionarla con variables demográficas (sexo, edad) y otros indicadores de salud (diagnóstico de COVID-19, comorbilidades y embarazo). Metodología: Estudio descriptivo, observacional, de corte transversal. Al personal de salud con un resultado positivo en una primera muestra (N=388) se les realizó una segunda prueba para evaluar la persistencia de anticuerpos mediante ELISA. Resultados: De las 386 personas evaluadas con resultado concluyente, 296 contaban con un primer resultado positivo entre los 30 y los 90 días anteriores a la segunda prueba, el 90% presentó anticuerpos detectables. En aquellas personas con un resultado positivo hacía más de 90 días (45) se observó una caída significativa en la persistencia del 26,7%. No hubo asociaciones significativas entre las variables demográficas y de salud y el resultado de la segunda prueba. Conclusión: Los anticuerpos se mantienen detectables por al menos 90 días en el 90% de los casos analizados. Resulta fundamental continuar este estudio en el tiempo para contar con un período de tiempo mayor entre pruebas. La información aquí mostrada arroja datos interesantes y prometedores en cuanto a la posible protección de nuevos contagios de COVID-19 en personal con alta exposición de riesgo. Estas evidencias podrían contribuir a la toma de decisiones, tanto a nivel local como regional, para la adecuada planificación de la vacunación, así como también, para el manejo de la pandemia ante una posible segunda ola de casos en América Latina.

https://doi.org/10.1590/SciELOPreprints.1634

[SciELO Preprints] - Community isolation as a strategy to mitigate a COVID19 outbreak: a case study of Villa Azul, Argentina
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Esposito , Melina Bustos , Soledad Cardonetti, Leandro Alvarado , Maria Jose Pueyo Latorre, Berenice Parrilla , Luis Garcia , Enio Kreplak , Nicolas Konfino, Jonatan

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Data de publicação: 2020-10-15

Resumo: En Es

Introduction: After the identification of the occurrence of a COVID19 outbreak in the Villa Azul neighborhood and given the neighborhood's vulnerability characteristics that would make it difficult to comply with quarantine and prevention measures, a community isolation strategy was implemented as a health response to the outbreak. Objective: to describe the community isolation strategy used in the Villa Azul neighborhood to contain and mitigate a COVID19 outbreak.Methods: The boundaries of the neighborhood were closed with security forces. Circulation within the neighborhood was allowed assuming that all the inhabitants were suspected cases of COVID19 or were close contacts of a case. In the following days, the active search for suspected cases of COVID19 continued, swabs were carried out in the neighborhood and the results were obtained at 24 hours. Every day, after receiving the cases, the negative cases were informed of the result and the positive cases went to the houses to notify them of the result and suggest isolation outside the neighborhood to cut the chain of infectionsResults: In the Villa Azul neighborhood, between May 22 and June 20, 731 suspected cases were registered, of which 379 were confirmed cases for COVID19 (accumulated positivity rate of 52.1%). The first week there were between 20 and 40 confirmed daily cases with a positivity rate between 66 and 81%, but as time went by as a consequence of the strategy described, the number of cases per day and also the positivity decreased. 193 confirmed patient transfers were transferred to isolate themselves outside the neighborhood. 3 people died, all with comorbidities (letality rate 0.8%).Discussion: The community isolation strategy was effective in containing the COVID19 outbreak in the Villa Azul neighborhood. The possibility of guaranteeing the active search for cases on a daily basis, added to the possibility of swabbing them in the neighborhood and having the result after 24 hours plus suggesting the transfer out of the same of those confirmed for COVID19 were some of the keys.

Introducción: frente a la identificación de la ocurrencia de un brote de COVID19 en el Barrio de Villa Azul y dadas las características de vulnerabilidad del barrio que dificultarían cumplir con el aislamiento domiciliario y las medidas de prevención se implementó una estrategia de aislamiento comunitario como respuesta sanitaria al brote.    Objetivo: describir la estrategia de aislamiento comunitario utilizada en el Barrio de Villa Azul para contener y mitigar un brote de COVID19. Métodos: Se identificaron los límites del barrio y se procedió al cierre del mismo con fuerzas de seguridad. Quedó permitida la circulación por dentro del barrio asumiendo que todos los habitantes eran casos sospechosos de COVID19 o bien eran contactos estrechos de algún caso. En los días subsiguientes se continuó con la búsqueda activa de casos sospechosos de COVID19, se realizaron los hisopados en el barrio y se obtuvieron los resultados a las 24 horas. Todos los días, luego de la recepción de los casos se les informaba el resultado a los casos negativos y se iba a las casas de los casos positivos para notificarlos del resultado y sugerirles el aislamiento fuera del barrio para cortar la cadena de contagios. Resultados: En el barrio Villa Azul entre el 22 de mayo y el 20 de junio se registraron 731 casos sospechosos de los cuales 379 fueron casos confirmados para COVID19 (tasa de positividad acumulada del 52,1%). La primera semana hubo entre 20 y 40 casos confirmados diarios con un índice de positividad entre el 66 y 81% pero con el correr del tiempo como consecuencia de la estrategia descripta fueron bajando el número de casos por día y también la positividad. Se trasladaron 193 traslados de pacientes confirmados para aislarse afuera del barrio. Fallecieron 3 personas, todas con comorbilidades (tasa de letalidad 0,8%).  Discusión: La estrategia de aislamiento comunitario resultó efectiva para contener el brote de COVID19 en el Barrio de Villa Azul. La posibilidad de garantizar de forma diaria la búsqueda activa de casos, sumado a la posibilidad de hisoparlos en el barrio y a las 24 horas tener el resultado, sugiriendo luego el traslado fuera del mismo de los confirmados para COVID19 fueron algunas de las claves.

https://doi.org/10.1590/SciELOPreprints.1366

[SciELO Preprints] - Surveillance and Seroprevalence: Evaluation of IgG antibodies for SARS-Cov2 by ELISA in the popular neighborhood Villa Azul, Quilmes, province of Buenos Aires, Argentina
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Muñoz, Laura Pífano, Marina Bolzán, Andres Varela, Teresa Comes, Yamila Specogna, Mariana Ceriani, Leticia Konfino, Jonatan Kreplak, Nicolás Garcia, Enio

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Data de publicação: 2020-08-28

Resumo: En Es Pt

Objective: To evaluate the prevalence of antibodies against SARS Cov-2 in Barrio Villa Azul, in the Quilmes district, together with other demographic and mobility variables. Methods: Descriptive cross-sectional study carried out through a systematic probabilistic sample. The sample consisted of 311 cases, of which 284 cases consented to the application of the test. A survey was applied to 100% of the cases tested. The information was processed with SPSS 23 software and the analysis considered the weighting of the sample according to the established probabilistic design. Results: 61% were women. The mean age was 40 years, the population structure was similar to that of the universe. The presence of antibodies was 14.8% of the cases, the majority in women and 40 year-old who did not go to work and did not use public transport. Being a health worker did not represent a greater risk for infection. It is observed that of each symptomatic case there would be 1.2 asymptomatic. Conclusions: There was a higher prevalence of people with antibodies than in other studies, although comparing similar territories the prevalence of antibodies was lower and this could be a consequence of a timely territorial approach. The seroprevalence was predominantly in women and this would not indicate greater contagion in this sex since there is uncertainty in the relationship between infection and antibodies. It was observed that the infections could have been within the home or in the community environment since it affected people who did not go out to work.

Objetivo: Evaluar la prevalencia de anticuerpos para SARS Cov-2 en el Barrio Villa Azul, del partido de Quilmes, junto con otras variables demográficas y de movilidad. Métodos: Estudio descriptivo de corte transversal realizado a través de una muestra probabilística sistemática. El tamaño de la muestra fue de 311 casos y consintieron la aplicación del test 284 casos. Fue aplicada una encuesta al 100% de los casos testeados. La información fue procesada con software SPSS 23 y los análisis consideraron la ponderación de la muestra de acuerdo al diseño equiprobabilístico establecido. Resultados: El 61% eran mujeres. La media de edad era de 40 años, la estructura poblacional era similar a la del universo. La presencia de anticuerpos fue del 14,8% de los casos, la mayoría en mujeres y de 40 años que no salieron a trabajar y no utilizaron transporte público. El ser trabajador de la salud no representó un riesgo acrecentado para el contagio. Se observa que de cada un caso sintomático existirían 1,2 asintomáticos. Conclusiones: Hubo una prevalencia mayor de personas con anticuerpos que en otros estudios, aunque comparando territorios similares la prevalencia de anticuerpos fue menor y esto pude ser una consecuencia de un abordaje territorial oportuno. La seroprevalencia fue predominantemente en mujeres y esto no indicaría mayor contagio en este sexo ya que existe incertidumbre en la relación entre infección y anticuerpos. Se observó que los contagios podrían haber sido dentro del hogar o el entorno comunitario ya que afectó a personas que no salían a trabajar.

Objetivo: Avaliar a prevalência de anticorpos para SARS-cOV2 no bairro Villa Azul do Município de Quilmes na Argentina. Métodos: Estudo descritivo de corte transversal realizado a partir de uma amostra probabilística sistemática. O tamanho da amostra foi de 311 casos sendo que aceitaram a realização da prova 248 casos. Foi aplicado um formulário a todos os casos testados. A informação foi processada com o software SPSS 23 e as análises tomaram em conta a ponderação da amostra de acordo ao desenho probabilístico estabelecido. Resultados: O 61% eram mulheres. A média de idade foi de 40 anos, a estrutura populacional era similar à do universo de estudo. A presença de anticorpos foi no 14,8% dos casos, maioria mulheres, de 40 anos e que não saíram para o trabalho e a maioria não usaram o transporte público. O fato de ser trabalhador da saúde não acrescentou o risco do contagio. Observou-se que por cada caso sintomático houveram 1,2 casos assintomáticos. Conclusões: Houve uma prevalência maior de anticorpos do que em outros estudos. A soroprevalência foi maior em mulheres e isto não estaria indicando maior contagio em este sexo devido à incerteza entre a relação entre infeção e anticorpos. Observou-se que os contágios poderiam ter acontecido dentro do lar e no entorno comunitário já que afetou ás pessoas que não saiam para trabalhar

https://doi.org/10.1590/SciELOPreprints.1147

10.

Pegvisomant in acromegaly: a multicenter real-life study in Argentina
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Basavilbaso, Natalia Ximena Garcia

; Ballarino, Maria Carolina

; Bruera, Darío

; Bruno, Oscar D.

; Chervin, Alberto B.

; Danilowicz, Karina

; Fainstein-Day, Patricia

; Fidalgo, Silvina Gabriela

; Frigeri, Adriana

; Glerean, Mariela

; Guelman, Rodolfo

; Isaac, Gabriel

; Katz, Debora Adela

; Knoblovits, Pablo

; Librandi, Fabiana

; Montes, Monica López

; Mallea-Gil, Maria Susana

; Manavela, Marcos

; Mereshian, Paula

; Moncet, Daniel

; Pignatta, Analia

; Rogozinsky, Amelia

; Sago, Laura R.

; Servidio, Marisa

; Spezzi, Monica

; Stalldecker, Graciela

; Tkatch, Julieta

; Vitale, Nicolas Marcelo

; Guitelman, Mirtha

Archives of Endocrinology and Metabolism

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Ago 2019, Volume 63 Nº 4 Páginas 320 - 327

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective To describe the long term safety and efficacy of pegvisomant (PEGV), and the predictors of treatment response in patients with acromegaly in the real life setting. Subjects and methods We retrospectively reviewed the clinical, hormonal and radiological data of acromegalic patients treated with PEGV in 17 Argentine centers. Results Seventy-five patients (age range 22-77, 51 females) with acromegaly have been treated with PEGV for up to 118 months (median 27 months). Before PEGV, 97.3% of patients had been treated with medical therapy, surgery and/or radiotherapy, two patients had no previous treatment. At that time, all patients had an IGF-1 above the upper normal limit (ULN) (mean 2.4 x ULN ± 0.98, range 1.25-7). At diagnosis of acromegaly 84% presented macroadenomas, prior to PEGV only 23,5% of patients remained with tumor remnant > 1 cm, the remaining showed normal or less than 1 cm images. Disease control (IGF-1 ≤ 1.2 x ULN) was achieved in 62.9% of patients with a mean dose of 11.8 mg/day. Thirty-four patients (45%) received PEGV monotherapy, while 41 (55%) received combined therapy with either somatostatin analogues and/or cabergoline. Adverse events related to PEGV were: local injection site reaction in 5.3%, elevated liver enzymes in 9.3%, and tumor size growth in 9.8%. Pre-PEGV IGF-I level was the only predictor of treatment response: 2.1 x ULN vs 2.8 x ULN in controlled and uncontrolled patients respectively (p < 0.001). Conclusion this long term experience indicates PEGV treatment was highly effective and safe in our series of Argentine patients with acromegaly refractory to standard therapies. Arch Endocrinol Metab. 2019;63(4):320-7

https://doi.org/10.20945/2359-3997000000160 1306 downloads

11.

Critical Forces at Fractional Matching Fields in Superconducting Thin Films with Triangular Pinning Lattice
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Vizarim, Nicolas Porto

; Carlone, Maicon

; Verga, Lucas Garcia

; Venegas, Pablo Antonio

Materials Research

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Ago 2017, Volume 20 Nº 4 Páginas 899 - 903

Resumo: En | Texto: En | PDF: En

We numerically study the commensurability effects in the critical forces in a type II superconducting thin film with vortices under the influence of a triangular pinning lattice at sub matching fields and zero temperature. The analysis is made applying a transport force in two mutually perpendicular directions and magnetic field perpendicular to the film surface. The results show critical force peaks at fractional matching fields, as a direct consequence of the commensurability effects. For the first time, we simulate the sequence of force peaks detected in recent experiments. Anisotropic effects in the critical forces are also reported, in analogy with that found at higher fields.

https://doi.org/10.1590/1980-5373-mr-2016-0696 535 downloads

12.

Host response mechanisms in periodontal diseases
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SILVA, Nora

; ABUSLEME, Loreto

; BRAVO, Denisse

; DUTZAN, Nicolás

; GARCIA-SESNICH, Jocelyn

; VERNAL, Rolando

; HERNÁNDEZ, Marcela

; GAMONAL, Jorge

Journal of Applied Oral Science

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Jun 2015, Volume 23 Nº 3 Páginas 329 - 355

Resumo: En | Texto: En | PDF: En

Periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Treponema denticola that trigger innate, inflammatory, and adaptive immune responses. These processes result in the destruction of the tissues surrounding and supporting the teeth, and eventually in tissue, bone and finally, tooth loss. The innate immune response constitutes a homeostatic system, which is the first line of defense, and is able to recognize invading microorganisms as non-self, triggering immune responses to eliminate them. In addition to the innate immunity, adaptive immunity cells and characteristic cytokines have been described as important players in the periodontal disease pathogenesis scenario, with a special attention to CD4+ T-cells (T-helper cells). Interestingly, the T cell-mediated adaptive immunity development is highly dependent on innate immunity-associated antigen presenting cells, which after antigen capture undergo into a maturation process and migrate towards the lymph nodes, where they produce distinct patterns of cytokines that will contribute to the subsequent polarization and activation of specific T CD4+ lymphocytes. Skeletal homeostasis depends on a dynamic balance between the activities of the bone-forming osteoblasts (OBLs) and bone-resorbing osteoclasts (OCLs). This balance is tightly controlled by various regulatory systems, such as the endocrine system, and is influenced by the immune system, an osteoimmunological regulation depending on lymphocyte- and macrophage-derived cytokines. All these cytokines and inflammatory mediators are capable of acting alone or in concert, to stimulate periodontal breakdown and collagen destruction via tissue-derived matrix metalloproteinases, a characterization of the progression of periodontitis as a stage that presents a significantly host immune and inflammatory response to the microbial challenge that determine of susceptibility to develop the destructive/progressive periodontitis under the influence of multiple behavioral, environmental and genetic factors.

https://doi.org/10.1590/1678-775720140259 26689 downloads

13.

Growth and survival of Hippocampus erectus (Perry, 1810) juveniles fed on Artemia with different HUFA levels
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Vite-Garcia, Nicolás

; Simoes, Nuno

; Arjona, Olivia

; Mascaro, Maite

; Palacios, Elena

Latin american journal of aquatic research

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Mar 2014, Volume 42 Nº 1 Páginas 150 - 159

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Survival during first months after birth is one of the bottlenecks for consolidating the seahorse farming industry. In this work, Artemia metanauplii enriched with two highly unsaturated fatty acids (HUFA) rich commercial emulsions with different docosahexaenoic acid (DHA) levels (63% and 14% of total lipids), a vegetable oil with no DHA, and non-enriched Artemia as control, were used to feed 5-day-old juvenile Hippocampus erectus for 60 days. Enriched Artemia had similar levels of DHA (13% and 9%), despite great differences of DHA in the emulsions, with traces of DHA in non-enriched and vegetable oil enriched Artemia. More than 20% of DHA was found in 24 h starved juveniles fed both DHA-enriched treatments, similar to values in newly born juveniles, but those fed vegetable oil enriched Artemia or non-enriched Artemia had 5% of DHA. Total lipid and protein levels were similar in juveniles from the four treatments. The n-3/n-6 ratio was almost four-fold higher in seahorses fed DHA-enriched treatments compared to juveniles fed the non-enriched treatments. Survival of seahorses only partially reflected the DHA levels: it was lower in the vegetable oil treatment, similar in the seahorses fed Artemia with higher DHA and in the control treatment, and higher in seahorses fed the HUFA-enriched Artemia with lower DHA levels, although growth was similar in the two DHA-enriched Artemia treatments. Juvenile H. erectus seahorses perform better when they have at least 20% of DHA in their tissues, and these levels can be attained with no more than 14% of DHA in emulsions, eliminating the need for more expensive emulsions with higher DHA levels.

La sobrevivencia durante los primeros meses de vida es uno de los cuellos de botella para la consolidación de la industria del cultivo del caballito de mar (Hippocampus erectus). En este trabajo se utilizaron metanauplios enriquecidos con dos emulsiones comerciales, con diferentes niveles de ácido docosahexaenóico (DHA) (63% y 14%), con aceite vegetal sin DHA, y metanauplios sin enriquecimiento como control, para alimentar caballitos de mar de 5 días de vida durante 60 días. La Artemia enriquecida tuvo niveles similares de DHA (13% y 9%), a pesar de las grandes diferencias en las emulsiones, con trazas de DHA en la Artemia no enriquecida y la enriquecida con aceite vegetal. Se obtuvo más de 20% de DHA en juveniles, muestreados con 24 h de ayuno, de los tratamientos con enriquecimiento de DHA, con valores similares a los de caballitos recién nacidos, pero los caballitos que se alimentaron con Artemia enriquecida con aceite vegetal y con Artemia no enriquecida tuvieron 5% de DHA. Los lípidos y proteínas totales fueron similares en los caballitos de los cuatros tratamientos. La razón n-3/n-6 fue casi cuatro veces mayor en caballitos alimentados con los tratamientos ricos en DHA comparados con los otros dos tratamientos. La sobrevivencia de caballitos de mar estuvo reflejada parcialmente por los niveles de DHA: fue mínima en caballitos del tratamiento de aceite vegetal, intermedia y similar en caballitos del tratamiento control y en los del tratamiento con enriquecimiento de HUFA (ácidos grasos altamente insaturados) con mayores niveles de DHA, y resultó máxima en caballitos del tratamiento enriquecido con HUFA con menores niveles de DHA. Juveniles de H. erectus tienen un mejor desempeño cuando tienen en sus tejidos 20% de DHA, y estos niveles pueden ser alcanzados con no más de 14% de DHA en las emulsiones, eliminado la necesidad de utilizar emulsiones con mayores niveles de este ácido graso, que tienen un precio más elevado.

2926 downloads Citado 1 vez em SciELO

14.

Blends of soybean biodiesel with petrodiesel: direct quantitation via mass spectrometry
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Abdelnur, Patrícia V.

; Saraiva, Sergio A.

; Catharino, Rodrigo R.

; Coelho, Mirela

; Schwab, Nicolas

; Garcia, Camila M.

; Schuchardt, Ulf

; Souza, Vanderléa de

; Eberlin, Marcos N.

Journal of the Brazilian Chemical Society

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Jun 2013, Volume 24 Nº 6 Páginas 946 - 952

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Quantificação e identificação de misturas de biodiesel de soja com petrodiesel foram realizadas via espectrometria de massas utilizando duas técnicas de ionização: electrospray (ESI) e Venturi easy ambient sonic-spray em seu modo líquido (V L-EASI). Diferentes misturas de biodiesel/petrodiesel (de B0 até B100) foram diluídas e diretamente injetadas e analisadas por ambas as técnicas. Para investigar a adulteração em blendas Bn, misturas óleo de soja/biodiesel e óleo de soja/petrodiesel foram analisadas. Curvas analíticas foram obtidas em triplicata. As duas técnicas apresentaram quantificação suficientemente precisa na faixa de B1-B20. Estas técnicas foram úteis também na detecção de contaminação ou adulteração das misturas Bn com óleos vegetais. A técnica de ESI é hoje largamente difundida e comercialmente acessível enquanto que uma fonte de V L-EASI pode ser facilmente montada usando peças comuns de laboratório dispensando a aplicação de altas voltagens. As duas técnicas não necessitam de etapas de pré-separação ou derivatização e, portanto, oferecem métodos simples e rápidos para quantificação de misturas Bn. A detecção instantânea e abrangente da composição molecular permite o controle de qualidade e tipificação de biodiesel e, eventualmente, de óleos vegetais em misturas ilegais.

Quantitation and identification of blends of soybean biodiesel with petrodiesel were performed via mass spectrometry using two ionization techniques: electrospray ionization (ESI) and Venturi easy ambient sonic-spray ionization in its liquid mode (V L-EASI). Different soybean biodiesel/petrodiesel blends (from B0 to B100) were diluted and then directly infused and analyzed by both techniques. To investigate adulteration of Bn blends, different soybean oil/biodiesel and soybean oil/petrodiesel blends were analyzed. Analytical curves were obtained in three replicates. The two techniques were shown to provide reasonably accurate quantitation in the B1-B20 range. These techniques were also successfully used to detect contamination or adulteration of Bn blends with vegetable oils. ESI is a widely used and commercially available technique whereas a V L-EASI source can be easily mounted using common laboratory parts requiring no use of high voltages. Both techniques require no pre-separation or derivatization steps and offer, therefore, simple and fast methods for the quantitation of Bn blends. The comprehensive snapshots of the molecular composition also allow quality control and typification of the biodiesel and eventually of the vegetable oils in illegal admixtures.

https://doi.org/10.5935/0103-5053.20130120 2092 downloads

15.

Bilateral tibial hemimelia type 1 (1a and 1b) with T9 and T10 hemivertebrae: a novel association
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Salinas-Torres, Victor Michael

; Barajas-Barajas, Leticia Oralia

; Perez-Garcia, Nicolas

; Perez-Garcia, Guillermo

Sao Paulo Medical Journal

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2013, Volume 131 Nº 4 Páginas 275 - 278

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

CONTEXTO Ausência congênita da tíbia é uma anomalia rara, com incidência em 1 por 1.000.000 de nascidos vivos, é principalmente esporádica e pode ser identificada como um distúrbio isolado ou como parte de síndromes de malformações. RELATO DO CASO Criança do sexo masculino, nascida de pais não afetados e não consanguíneos, apresentou-se com encurtamento das pernas e adução de ambos os pés. O exame físico realizado com seis meses de idade mostrou perímetro cefálico 44,5 cm (percentil 75), comprimento de 60 cm (percentil < 3), peso 7.700 g (percentil 50), encurtamento da coxa esquerda e as duas pernas com o pé varo bilateralhavia. Não houve dismorfismos craniofaciais, nem tórax, abdômen, genitais e anomalias das extremidades superiores. O desenvolvimento psicomotor foi normal. Os exames, incluindo ultrassonografia renal e da cabeça, potenciais auditivos evocados de tronco cerebral e exames oftalmológicos e cardiológicos, estavam normais. Raios-X revelou ausência bilateral da tíbia com fíbula intacta, hipoplasia distal do fêmur esquerdo e fêmur direito normal. Além disso, as radiografias de coluna mostraram hemivértebras em T9 e T10. CONCLUSÃO Esta associação nova expande o espectro de hemimelia tibial. Além disso, esta observação destaca a utilidade de tal método diagnóstico barato (raios-X), caracterizando a grande variabilidade clínica e radiológica de hemimelia tibial.

CONTEXT Congenital absence of the tibia is a rare anomaly with an incidence of one per 1,000,000 live births. It is mostly sporadic and can be identified as an isolated disorder or as part of malformation syndromes. CASE REPORT A male child, born to unaffected and non-consanguineous parents, presented with shortening of the legs and adduction of both feet. Physical examination at six months of age showed head circumference of 44.5 cm (75th percentile), length 60 cm (< 3rd percentile), weight 7,700 g (50th percentile), shortening of the left thigh and both legs with varus foot. There were no craniofacial dysmorphisms or chest, abdominal, genital or upper-extremity anomalies. Psychomotor development was normal. His workup, including renal and cranial ultrasonography, brainstem auditory evoked potential, and ophthalmological and cardiological examinations, was normal. X-rays showed bilateral absence of the tibia with intact fibulae, distally hypoplastic left femur, and normal right femur. In addition, spinal radiographs showed hemivertebrae at T9 and T10. CONCLUSION This novel association expands the spectrum of tibial hemimelia. Moreover, this observation highlights the usefulness of this inexpensive diagnostic method (X-rays) for characterizing the great clinical and radiological variability of tibial hemimelia.

https://doi.org/10.1590/1516-3180.2013.1314494 3919 downloads

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