Pesquisa | SciELO

Resumo No atual contexto de patógenos fúngicos resistentes emergentes tais como Candida albicans e Candida parapsilosis, a descoberta de novos agentes antifúngicos é uma questão urgente. Esta pesquisa teve como objetivo avaliar o potencial antifúngico da 2-cloro-N-fenilacetamida contra cepas clínicas de C. albicans e C. parapsilosis resistentes a fluconazol. A atividade antifúngica da substância foi avaliada in vitro através da determinação da concentração inibitória mínima (CIM), concentração fungicida mínima (CFM), ruptura e inibição da formação de biofilme, ensaios de sorbitol e ergosterol, e associação entre esta molécula e antifúngicos comuns, anfotericina B e fluconazol. O produto teste inibiu todas as cepas de C. albicans e C. parapsilosis, com uma CIM variando de 128 a 256 µg.mL-1, e uma CFM de 512-1,024 µg.mL-1. Também inibiu até 92% da formação de biofilme e causou a ruptura de até 87% de biofilme pré-formado. A 2-cloro-N-fenilacetamida não promoveu atividade antifúngica pela ligação ao ergosterol da membrana celular fúngica, tampouco danificou a parede celular. Antagonismo foi observado ao combinar esta substância com anfotericina B e fluconazol. A substância exibiu atividade antifúngica significativa ao inibir tanto as células planctônicas quanto o biofilme das cepas resistentes ao fluconazol. Sua combinação com outros antifúngicos deve ser evitada e seu mecanismo de ação deve ser estabelecido.

Abstract In the current context of emerging drug-resistant fungal pathogens such as Candida albicans and Candida parapsilosis, discovery of new antifungal agents is an urgent matter. This research aimed to evaluate the antifungal potential of 2-chloro-N-phenylacetamide against fluconazole-resistant clinical strains of C. albicans and C. parapsilosis. The antifungal activity of 2-chloro-N-phenylacetamide was evaluated in vitro by the determination of the minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), inhibition of biofilm formation and its rupture, sorbitol and ergosterol assays, and association between this molecule and common antifungal drugs, amphotericin B and fluconazole. The test product inhibited all strains of C. albicans and C. parapsilosis, with a MIC ranging from 128 to 256 µg.mL-1, and a MFC of 512-1,024 µg.mL-1. It also inhibited up to 92% of biofilm formation and rupture of up to 87% of preformed biofilm. 2-chloro-N-phenylacetamide did not promote antifungal activity through binding to cellular membrane ergosterol nor it damages the fungal cell wall. Antagonism was observed when combining this substance with amphotericin B and fluconazole. The substance exhibited significant antifungal activity by inhibiting both planktonic cells and biofilm of fluconazole-resistant strains. Its combination with other antifungals should be avoided and its mechanism of action remains to be established.

https://doi.org/10.1590/1519-6984.255080

Rehabilitation in post-cardiac transplantation. Experience in Mexico's General Hospital
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Martínez-Camacho, Miguel Á.

; Jones-Baro, Robert A.

; Melo-Villalobos, Andrea

; Morales-Hernández, Diego

; Cruz-Rivero, Monserrat

; Ku-González, Andrés

; Ayala-Hernández, Eduardo

; Castaño-Guerra, José R.

Revista médica del Hospital General de México

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Dez 2023, Volume 86 Nº 4 Páginas 156 - 160

Resumo: En | Texto: En | PDF: En

Abstract Post-heart transplant patient care is a challenging task for multidisciplinary teams. Thus, patient rehabilitation is of paramount importance. Phase I of cardiac rehabilitation helps prevent the pulmonary and functional sequelae found in patients whilst in ICU and during hospitalisation. Functional progression based on the global muscle strength, mobility, and exercise tolerance seem to be a good alternative for this population. The role of physiotherapy in critical care is crucial for the proper treatment of these patients.

https://doi.org/10.24875/hgmx.23000003

A thrombus trapped in a patent foramen ovale: a migrant out of the ordinary
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Nombera, Natalia R.

; Guerra, Mauricio

; Alvarado, María de los Ángeles G.

; Bernal, Mary A.

Archivos de cardiología de México

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Dez 2023, Volume 93 Nº 4 Páginas 500 - 501

Resumo: En | Texto: En | PDF: En

https://doi.org/10.24875/acm.22000220

Rendimiento diagnóstico de once indicadores para resistencia a la insulina en una muestra de pobladores peruanos
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Vera-Ponce, Víctor Juan

; Valencia, Jamee Guerra

; Poma, Miguel Ángel

; Loayza-Castro, Joan A.

; Zeñas-Trujillo, Gianella Zulema

; Zuzunaga-Montoya, Fiorella E.

; Torres-Malca, Jenny Raquel

; Cruz-Vargas, Jhony A. De La

Medicina clínica y social

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Dez 2023, Volume 7 Nº 3 Páginas 168 - 176

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Introducción: La resistencia a la insulina (RI) es una de las principales causas del desarrollo de patologías crónicas. Es indispensable su detección temprana, por ello es importante estudiar métodos más asequibles y menos costosos como los biomarcadores. Objetivo: Determinar la precisión diagnóstica de once biomarcadores para RI en una muestra de pobladores peruanos. Metodología: Estudio de pruebas diagnósticas. Análisis de base de datos secundario del estudio PERU MIGRANT. Para medir RI se utilizó como referencia la evaluación del modelo homeostático (HOMA-IR) ≥ 2,8. Los biomarcadores se basaron en la ratio de lípidos, los indicadores de lípido visceral, los indicadores con triglicéridos y glucosa (TyG), y los indicadores con cintura abdominal. Para la precisión se utilizó el análisis de la curva de características operativas del receptor y el área bajo la curva (AUC) con sus respectivos intervalos de confianza al 95% (IC95%). Resultados: Se estudió a 938 participantes. La prevalencia de RI fue del 9,91%. En relación con el análisis ROC, el índice TyG - índice de masa corporal (TyG - IMC) tuvo el mayor AUC, tanto en hombres: AUC=0,85 (0,81 - 0,90), corte=241,55; sens=92,5 (79,6 - 98,4) y esp=78,3 (73,9 - 82,2); como en mujeres: AUC=0,81 (0,76 - 0,85), corte=258,77; sens=79,2 (70,3 - 86,5) y esp= 82,1 (78,0 - 85,8). Discusión: Según los datos analizados, el índice TyG-IMC es el mejor indicador para medir RI. Es un índice simple que se puede tomar de manera rutinaria en la práctica clínica diaria. Es conveniente añadir futuros estudios prospectivos que confirmen su capacidad predictiva.

ABSTRACT Introduction: Insulin resistance (IR) is one of the main causes of chronic disease. Early detection is essential, which is why it is important to study more affordable and less expensive methods, such as biomarkers. Objective: To determine the diagnostic accuracy of 11 biomarkers of IR in a sample of Peruvian residents. Method: diagnostic tests. Secondary Database Analysis of the PERU-MIGRANT Study. To measure RI, a homeostatic model evaluation (HOMA-IR) ≥ 2.8 was used as a reference. Biomarkers were based on the lipid ratio, visceral lipid indicators, indicators of triglycerides and glucose (TyG), and indicators of abdominal waist. For precision, the receiver operating characteristic curve and area under the curve (AUC) with their respective 95% confidence intervals (95%CI) were used. Results: A total of 938 participants were studied. The prevalence of IR was 9.91%. In relation to the ROC analysis, the TyG index - body mass index (TyG - BMI) had the highest AUC, both in men: AUC=0.85 (0.81 - 0.90), cut-off=241.55; sens=92.5 (79.6 - 98.4) and sp=78.3 (73.9 - 82.2); as in women: AUC=0.81 (0.76 - 0.85), cut-off=258.77; sens=79.2 (70.3 - 86.5) and esp= 82.1 (78.0 - 85.8). Discussion: According to the data analyzed, the TyG-IMC index is the best indicator for measuring IR. It is a simple index that can be routinely used in clinical practice. Future prospective studies are needed to confirm its predictive capacity.

https://doi.org/10.52379/mcs.v7i3.292

Diversidad y estructura de especies arbóreas en localidades rurales de Hualahuises, México
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Molina Guerra, Víctor Manuel

; Alanís Rodríguez, Eduardo

; Mora Olivo, Arturo

; Rubio Camacho, Ernesto A.

; González Cuellar, Andrés Tzolkin

Revista mexicana de ciencias forestales

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Out 2023, Volume 14 Nº 79 Páginas 344 - 354

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen En este estudio se evaluó la proporción de especies arbóreas nativas respecto a las introducidas en bosques urbanos de seis zonas rurales de Hualahuises, Nuevo León (noreste de México). Para el análisis de varianza se utilizó la prueba de proporciones con un nivel de confianza de 0.95 mediante el comando prop.test en R. Se registraron 252 individuos de 32 especies distribuidas en 29 géneros y 19 familias. La familia Fabaceae fue la mejor representada con siete especies. De todos los taxones, 19 son nativos (59.37 %) y 13 introducidos (40.63 %). De acuerdo con su origen, 77.79 % de los individuos son nativos y 22.21 % introducidos. Referente a sus dimensiones, las diferencias porcentuales son mayores: las nativas representan 91.69 % de área basal, 92.36 % de área de copa, 92.22 % de área superficial de la copa y 96.78 % de volumen de copa, mientras que las no nativas presentan valores inferiores a 9.00 %. Prosopis laevigata, seguida de Vachellia farnesiana y Ebenopsis ebano presentaron los valores estructurales más altos. Las tres son nativas pertenecientes a la familia Fabaceae y juntas conforman 44.05 % de la abundancia y 63.71 % del Índice de Valor de Importancia Urbano. Con base en el análisis de varianza, las especies nativas resultaron tener mayores valores de riqueza, área basal y área superficial de copa que las introducidas en las localidades evaluadas.

Abstract In this study, the proportion of native vs. introduced tree species in urban forests of six rural areas of Hualahuises, Nuevo León (Northeast Mexico) was evaluated. For the analysis of variance, the proportions test was used with a confidence level of 0.95 through the prop.test command in R. 252 individuals of 32 species distributed in 29 genera and 19 families were recorded. The Fabaceae family was the largest represented with seven species. Of the 32 species, 19 are native (59.37 %) and 13 introduced (40.63 %). Based upon their origin, 77.79 % of the individuals are native and 22.21 % introduced. Regarding their dimensions, the percentage differences are greater: the native ones represent 91.69 % of the basimetric area, 92.36 % of the crown area, 92.22 % of the assumed crown area and 96.78 % of crown volume, while the non-natives present values lower than 9.00 %. At the species level, those with the highest structural values were Prosopis laevigata followed by Vachellia farnesiana and Ebenopsis ebano. The three species are native belonging to the Fabaceae family and together they represent 44.05 % of the abundance and 63.71 % of the Urban Importance Value Index. According to the analysis of variance, the native species turned out to have higher values of richness, basal area, and crown area than the introduced species in the assessed localities.

https://doi.org/10.29298/rmcf.v14i79.1343

Enfermedades endocrinas asociadas a vacunación por la COVID-19: reporte de casos
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Teruya-Gibu, Alberto A.

; Ortiz-Guerra, Percy

; Arzapalo-Poma, Abad A.

Revista Peruana de Medicina Experimental y Salud Pública

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Set 2023, Volume 40 Nº 3 Páginas 364 - 368

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La vacunación contra el SARS-CoV-2 no está exenta de efectos adversos. Se presenta dos casos de afectación endocrina asociada a la vacunación por la COVID-19. Mujer de 46 años que, luego de la primera dosis, presentó fiebre persistente y signos de tirotoxicosis, tras el diagnóstico de tiroiditis subaguda asociada a vacunación por la COVID-19, el cuadro remitió con el uso de corticoides. Varón de 71 años, que luego de la vacunación por la COVID-19, presentó hipoglicemias hiperinsulinemicas, con resultado positivo de anticuerpos antiinsulina. Se le diagnosticó con una hipoglicemia autoinmune asociada a la vacunación por la COVID-19 y recibió tratamiento con prednisona, controlando los episodios de hipoglicemia. En conclusión, las enfermedades endocrinas asociadas a vacunación por la COVID-19 son extremadamente raras y su detección oportuna permite su tratamiento adecuado.

ABSTRACT SARS-CoV-2 vaccination is not free of adverse effects. We present two cases of endocrine involvement associated with COVID-19 vaccination. A 46-year-old woman who, after receiving the first COVID-19 vaccination dose, presented persistent fever and signs of thyrotoxicosis after being diagnosed with subacute thyroiditis associated with COVID-19 vaccination; the condition remitted with the use of corticoids. A 71-year-old male, who after COVID-19 vaccination, presented hyperinsulinemic hypoglycemia, testing positive for anti-insulin antibodies; he was diagnosed with autoimmune hypoglycemia associated with COVID-19 vaccination and received treatment with prednisone, controlling the episodes of hypoglycemia. In conclusion, endocrine diseases associated with COVID-19 vaccination are extremely rare and their timely detection allows adequate treatment.

https://doi.org/10.17843/rpmesp.2023.403.12572

Productivity and optimized economic efficiency of carrot roots in monocropping under green manuring
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Freitas, Isaac A. da S.

; Bezerra Neto, Francisco

; Lima, Jailma S. S. de

; Silva, Jéssica P. P. da

; Ferreira, Rayanna C.

; Guerra, Natan M.

Revista Caatinga

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Set 2023, Volume 36 Nº 3 Páginas 572 - 584

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT A great challenge of scientific research with carrot in semi-arid regions is obtaining the best productive characteristics and economic conditions by optimizing the green manure amounts using spontaneous species from the Caatinga biome, such as hairy woodrose (Merremia aegyptia L.) and roostertree (Calotropis procera Ait.). Therefore, this work aimed to agronomically and economically optimize the production of carrot roots in monocropping and of their components when fertilized with equitable biomass amounts of these spontaneous species in two cropping seasons in a semi-arid environment. The experimental design was a randomized complete block design, with five treatments and five replications. The treatments consisted of equitable amounts of hairy woodrose and roostertree biomass in amounts of 16, 29, 42, 55, and 68 t ha-1 on a dry basis. In each experiment, an additional carrot treatment without fertilizer (absolute control) was planted for comparison with the other treatments to determine maximum physical and economic efficiency. Carrot fertilization was performed with the incorporation of 48.87 t ha-1 of M. aegyptia and C. procera dry biomass into the soil to obtain the maximum optimized productive efficiency (commercial productivity). The maximum optimized agroeconomic efficiency (net income) of carrot cultivation was obtained when 49.64 t ha-1 of M. aegyptia and C. procera dry biomass was added to the soil. The use of biomass from these spontaneous species from the Caatinga biome as green manure is a viable technology for tuberose producers in monocropping in semiarid environments.

RESUMO Um grande desafio na pesquisa científica com cenoura em ambiente semiárido é obter as melhores características produtivas e condições econômicas otimizando as quantidades de adubos verdes de espécies espontâneas do bioma Caatinga, como a jitirana (Merremia aegyptia L.) e a flor-de-seda (Calotropis procera Ait.). Diante disso, esse trabalho teve como objetivo otimizar agronômica e economicamente a produção de raízes de cenoura em monocultivo e de seus componentes, quando adubados com quantidades equitativas de biomassa dessas espécies espontâneas, em duas estações de cultivos em ambiente semiárido. O delineamento experimental utilizado foi em blocos completos casualizados, com cinco tratamentos e cinco repetições. Os tratamentos consistiram de quantidades equitativas de biomassa de jitirana e de flor-de-seda nas doses de 16, 29, 42, 55 e 68 t ha-1 em base seca. Em cada experimento foi plantado um tratamento adicional com cenoura sem adubo (testemunha absoluta) para efeito de comparação com os demais tratamentos para determinar a máxima eficiência física ou econômica. A adubação da cenoura foi realizada com a incorporação de 48,87 t ha-1 de biomassa seca de M. aegyptia e C. procera ao solo para obtenção da máxima eficiência produtiva otimizada (produtividade comercial). A máxima eficiência agroeconômica otimizada (renda líquida) do cultivo da cenoura foi obtida quando 49,64 t ha-1 de biomassa seca de M. aegyptia e C. procera foram adicionados ao solo. A utilização da biomassa dessas espécies espontâneas do bioma Caatinga como adubação verde é uma tecnologia viável para produtores de tuberosas em monocultivo em ambientes semiáridos.

https://doi.org/10.1590/1983-21252023v36n310rc

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad extensa
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Cabrera-Miranda, Luis A.

; Díaz-García, Diego A.

; Corona-Cruz, José F.

; Lozano-Ruiz, Francisco J.

; Sánchez-Reyes, Roberto

; Álvarez-Bojórquez, Mario E.

; Blake-Cerda, Mónika

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Pérez-Álvarez, Sandra I.

; Bolaño-Guerra, Laura M.

; Alatorre-Alexander, Jorge A.

; Alexander-Meza, Francisco

; Barrón-Barrón, Feliciano

; Blanco-Vázquez, Yazmín C.

; Campos-Gómez, Saúl

; Mata-Moya, Dolores de la

; Figueroa-Martínez, Pedro

; González-Cisneros, Paulina E.

; Íñiguez-García, Marco A.

; Lázaro-León, Jesús M.

; Loyola-García, Ulises

; Morales-Rivera, Marcelino

; Olivares-Torres, Carlos

; Ramos-Ramírez, Maritza

; Sáenz-Frías, Julia A.

; Silva-Bravo, Fernando

; Trejo-Rosales, Rogelio

; Souto-del Bosque, Miguel

; Arrieta, Óscar

Gaceta mexicana de oncología

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Jun 2023, Volume 22 Nº 2 Páginas 55 - 73

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000122

A local height-diameter model with mixed-effects for Abies religiosa in Tlaxcala, Mexico
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Guerra-De la Cruz, Vidal

; Hernández-Ramos, Jonathan

; Buendía-Rodríguez, Enrique

; Tamarit-Urias, Juan Carlos

; Islas-Gutiérrez, Fabián

Bosque (Valdivia)

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Abr 2023, Volume 44 Nº 1 Páginas 137 - 147

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Height-diameter models are fundamental for the inventory of timber, biomass and carbon. Located in the central region of Mexico, Abies religiosa is a conifer with high timber value that lacks models to estimate its height as a function of diameter. The objective of this study was to determine a local height-diameter model for A. religiosa trees under a mixed-effects model approach in the region of Tlaxco, Tlaxcala, Mexico. The first step consisted in evaluating the quality of fit of three growth models and one power model. We used height-diameter data of 1,539 trees measured in 197 circular plots of 1,000 m2. The selected model was the Weibull, which was adjusted in a second step under the mixed-effects modelling approach. Our results showed that the most accurate predictive capacity was obtained when using the sub-basin covariate as a clustering factor and the random effect in the parameter corresponding to the asymptote. Under this approach, the goodness of fit of the model was superior to the traditional one adjusted by nonlinear least square. Comparatively the gains in fit statistics R2, RSME and AIC were of 12.19 %, 47.99 % and 8.46 %, respectively. The proposed model is robust, reliable, and biologically coherent for its operational application in the forest management of A. religiosa in the study region.

RESUMEN Los modelos de altura - diámetro son una pieza fundamental para realizar inventarios maderables, de biomasa y carbono. En la región central de México, Abies religiosa es una conífera de gran importancia comercial maderable la cual carece de modelos que estimen la altura en función del diámetro. El objetivo de este estudio fue determinar un modelo local altura-diámetro para árboles de A. religiosa bajo el enfoque de modelos con efectos mixtos en la región de Tlaxco, Tlaxcala, México. En la primera fase se evaluó la calidad de ajuste de tres modelos de crecimiento y un modelo potencial. Se utilizaron 1.539 pares de datos de altura-diámetro de árboles medidos en 197 sitios circulares de muestreo de 1.000 m2. El mejor modelo fue el de Weibull, mismo que en una segunda fase se ajustó mediante la técnica de modelos de efectos mixtos; en este caso, la mejor capacidad predictiva se obtuvo cuando se utilizó la covariable subcuenca como factor de agrupación y se incluyó un efecto aleatorio en el parámetro correspondiente a la asíntota. Bajo este enfoque el ajuste fue superior al ajuste tradicional por cuadrados mínimos no lineales. Comparativamente las ganancias en los estadísticos de ajuste R2, RCME y AIC fueron de 12,19 %, 47,99 % y 8,46 %, respectivamente. El modelo propuesto es robusto, confiable y biológicamente coherente para su aplicación operativa en la gestión forestal de las diferentes condiciones en que A. religiosa se desarrolla en la región de estudio.

https://doi.org/10.4067/s0717-92002023000100137

10.

Serpin-A3 is Associated with Persistent Albuminuria in Adolescents with Secondary Podocytopathy, in a Region with High Prevalence of Chronic Kidney Disease of Unknown Origin
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Zúñiga-Macías, Leslie P.

; Ramírez-Orozco, Ricardo E.

; Avelar-González, Francisco J.

; Pérez-Villalva, Rosalba

; Bobadilla, Norma A.

; Arreola-Guerra, José M.

Revista de investigación clínica

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Abr 2023, Volume 75 Nº 2 Páginas 53 - 62

Resumo: En | Texto: En | PDF: En

Abstract Background: The state of Aguascalientes, Mexico, has been recognized as a chronic kidney disease hotspot. Screening studies have revealed a high prevalence of persistent albuminuria (pA), histologically characterized by glomerulomegaly, and incomplete podocyte fusion, probably associated with oligonephrony. To date, urinary biomarkers have not been explored in this population. Objective: The aim of the study was to identify the presence of potential biomarkers of early renal injury in patients with pA (pACR) and that correspond with the characteristic nephropathy profile that prevails in this entity. Methods: This is a cross-sectional, analytical, and comparative study. Four groups were recruited: adolescents aged 10-17 years with pACR, isolated albuminuria (iACR), no albuminuria (negative control), and adults with biopsy-confirmed glomerulopathy (positive control). Urinary excretion of SerpinA3, heat-shock protein-72 (HSP-72), podocalyxin (PCX), and nephrin was evaluated in urine samples. SerpinA3 and HSP-72 were analyzed by Western blot, and PCX and nephrin were quantified by enzyme-linked immunosorbent assay. Results: The mean GFR in the pACR group was 113.4 mL/min/1.73m2 and differed significantly only from that of the positive control group (65.1 mL/min/1.73m2). The mean albuminuria value in the pACR group was 48.9 mg/g. SerpinA3 concentration differed between groups (0.08 vs. 0.25 ng/mL, p < 0.001): it was significantly higher in the pACR group compared to the negative controls (p = 0.037). Conclusion: SerpinA3 was significantly associated with pA and could become a biomarker of early kidney injury. Further investigations are required to determine whether SerpinA3 precedes the development of albuminuria and its pathogenic role.

https://doi.org/10.24875/ric.22000312

11.

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad limitada
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Cabrera-Miranda, Luis A.

; Lozano-Ruiz, Francisco J.

; Blake-Cerda, Mónika

; Corona-Cruz, José F.

; Sánchez-Reyes, Roberto

; Pérez-Álvarez, Sandra I.

; Díaz-García, Diego A.

; Álvarez-Bojórquez, Mario E.

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Bolaño-Guerra, Laura M.

; Maldonado-Magos, Federico

; Aldaco-Sarvide, Fernando

; Alvarado-Zermeño, Adriana

; Barajas-Figueroa, Luis J.

; Bautista-Aragón, Yolanda

; Bolaños-Morales, Francina V.

; Castillo-Ortega, Graciano

; Félix-Leyva, Jesús A.

; Gerson-Cwilich, Raquel

; Guzmán-de Alba, Enrique

; López-Galindo, Ángel A.

; Mariscal-Ramírez, Carlos

; Piñeiro-Retif, Rafael

; Ramos-Prudencio, Rubí

; Rodríguez-Cid, Jerónimo

; Silva-Bravo, Fernando

; Arrieta, Óscar

Gaceta mexicana de oncología

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Mar 2023, Volume 22 Nº 1 Páginas 3 - 23

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP, enfermedad limitada, en México, basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración entre el Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensuaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad limitada, producto de las preguntas de trabajo. Se identificó y evaluó críticamente la evidencia científica que responde a cada una de dichas preguntas clínicas, antes de incorporarla a la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad limitada del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica en estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by rapid growth rate and development of distant metastases. Objectives: To guide and standardize the treatment of limited disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: Consensus recommendations were reached, both by the Delphi method and in remote meetings, for limited SCLC disease resulting from the same number of work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the guide. Conclusion: This guide provides clinical recommendations for the management of limited disease SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000121

12.

Maximizing agro-bioeconomic benefits in intercropped systems of radish and lettuce in the semi-arid environment
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Lino, Francisca K. K. da S.

; Bezerra Neto, Francisco

; Santos, Elizangela C. dos

; Lima, Jailma S. S. de

; Chaves, Aridênia P.

; Rodrigues, Gardênia S. de O.

; Guerra, Natan M.

; Silva, Ítalo N.

; Lino, Vitor A. da S.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Fev 2023, Volume 27 Nº 2 Páginas 121 - 131

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O rabanete e a alface são duas hortaliças que podem ser consorciadas, porque são culturas companheiras que se complementam. Assim, este estudo teve como objetivo avaliar retornos agro-bioeconômicos advindos do consórcio rabanete-alface em diversas quantidades equitativas de biomassa de jitirana (Merremia aegyptia) e flor-de-seda (Calotropis procera) em diferentes densidades populacionais de alface, em ambiente semiárido. O delineamento experimental utilizado foi em blocos ao acaso, com os tratamentos dispostos em esquema fatorial 4 × 4, com quatro repetições. O primeiro fator consistiu em quantidades equitativas de biomassa de M. aegyptia e C. procera nas doses de 20, 35, 50 e 65 Mg ha-1 em base seca. O segundo fator compreendeu quatro densidades populacionais de alface de 150, 200, 250 e 300 mil plantas ha-1. As cultivares de alface e rabanete plantadas foram ‘Tainá’ e ‘Crimson Gigante’, respectivamente. Retornos agro-bioeconômicos expressivos deste consórcio de rabanete-alface foram obtidos na razão equivalente de terra (RET) de 2,25, escore da variável canônica Z de 3,00 e na renda liquida (RL) de 52.270,48 R$ ha-1, respectivamente, na quantidade de biomassa de 65 Mg ha-1 dos adubos verdes e densidade populacional de alface de 300 mil plantas ha-1. Além disso, registrou-se também um índice de eficiência produtiva (IEP) de 0,96 e uma razão competitiva (RC) de 2,61 na quantidade de biomassa dos adubos de 65 Mg ha-1 e densidade de alface de 150 mil plantas ha-1. A utilização de biomassa de M. aegyptia e C. procera do bioma Caatinga, mostrou-se uma tecnologia viável para produtores que praticam o cultivo de rabanete e alface em consórcio em ambiente semiárido.

ABSTRACT Radish and lettuce are two crop vegetables that can be intercropped because they are companion cultures that complement each other. Thus, this study aimed to evaluate agro-bioeconomic returns arising from radish-lettuce intercropping in different equitable amounts of hairy woodrose (Merremia aegyptia) and roostertree (Calotropis procera) biomass at different population densities of lettuce, in the semi-arid environment. The experimental design was in randomized blocks, with treatments arranged in a 4 × 4 factorial scheme with four replicates. The first factor consisted of equitable amounts of M. aegyptia and C. procera biomass at doses of 20, 35, 50, and 65 Mg ha-1 on a dry basis. The second factor comprised four lettuce population densities of 150, 200, 250, and 300 thousand plants ha-1. The lettuce and radish cultivars planted were ‘Tainá’ and ‘Crimson Gigante’, respectively. Expressive agro-bioeconomic returns from this radish-lettuce intercropping were obtained in the land equivalent ratio (LER) of 2.25, a score of the canonical variable Z of 3.00, net income (NI) of 52,270.48 R$ ha-1, respectively, in the biomass amount of 65 Mg ha-1 of the green manures and lettuce population density of 300 thousand plants ha-1. Also, there was a productive efficiency index (PEI) of 0.96 and a competitive ratio (CR) of 2.61 in the biomass amount of green manure of 65 Mg ha-1 and lettuce density of 150 thousand plants ha-1. Using M. aegyptia and C. procera biomass from the Caatinga biome proved to be a viable technology for producers who practice the cultivation of radish and lettuce in intercropping in the semi-arid environment.

https://doi.org/10.1590/1807-1929/agriambi.v27n2p121-131

13.

Mechanical behaviour of grapevine wood affected by Xylotrechus arvicola
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Rodríguez-González, Álvaro

; Casquero, Pedro A.

; Pereira, José A.

; González-López, Óscar

; Guerra, Marcos

; García-González, Julia

; Morán-Del Pozo, Julia M.

; Juan-Valdés, Andrés

Maderas. Ciencia y tecnología

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2023, Volume 25 elocation 16

Resumo: En | Texto: En | PDF: En

Abstract: The cerambycid insect Xylotrechus arvicola is considered a pest that affects the wood of the grapevine (Vitis vinifera) in the major wine areas of the Iberian Peninsula. The larva of this insect perforates the grapevine wood, resulting in structural and biomechanical failure of the vine plants. Vine samples from wood damaged by X. arvicola larvae were picked up from different vineyards and grape varieties. Compressive and flexural tests were performed in order to assess the mechanical behaviour of the wood samples. Total length of the cracks in wood samples (TLCWS) that appeared on the surface of the grapevine wood samples after the mechanical tests was measured. Compressive strength (CS) and flexural strength (FS) decreased with the increase of the cross-sectional area (CSA) of both branches and trunks, regardless of damage condition or water content. Moreover, the resistance was lower in damaged wood. In addition, this was verified through the linear regression coefficients of the interaction CS x CSA and FS x CSA. TLCWS in branches and trunks of damaged samples was greater that in undamaged samples. Also, TLCWS within the same damage condition and part of the plant was higher in dry samples than in fresh samples. The damaged wood would show a higher vulnerability to common mechanical stress suffered by the grapevines in the field including heavy winds, fruit overweight or harvesting machines shaking (when mechanically collected). Larvae of this insect altered the mechanical behaviour of the trunk and branches of grapevine wood. The mechanical strength of wood was more negatively affected when the CSA of the branches and trunks increased. Longer TLCWS was found in affected wood.

https://doi.org/10.4067/s0718-221x2023000100416

14.

Oceanographic conditions of the continental slope and deep waters in Santos Basin: the SANSED cruise (winter 2019)
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Silveira, Ilson C. A. da

; Bernardo, Piero S.

; Lazaneo, Cauê Z.

; Amorim, João P. M.

; Borges-Silva, Milton

; Martins, Rafael C.

; Santos, Daniel M. C.

; Dottori, Marcelo

; Belo, Wellington C.

; Martins, Renato P.

; Guerra, Luiz A. A.

; Moreira, Daniel L.

Ocean and Coastal Research

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2023, Volume 71 Supl. 3 elocation e23008

Resumo: En | Texto: En | PDF: En

Abstract This work describes the circulation over the continental slope and the São Paulo Plateau in the Santos Basin during the SANSED winter 2019 survey. The cruise consisted of four legs in the period between June, 11 and August, 03 2019. The observed circulation is dominated by the Atlantic southwestern boundary current regime and remotely-generated anticyclones and cyclones. The former is composed by the Brazil Current, the Intermediate Western Boundary Current and their mesoscale meanders; the latter are 300km vortical rings with origin in the eastern side of the South Atlantic Basin. A Lagrangian scheme applied over satellite altimeter maps indicate that the origin of these rings is primarily the Cape Basin of South Africa. The interaction between the boundary currents, their cyclonic meanders, and the anticyclonic rings is complex, and varies widely. During the SANSED winter 2019 survey period, three anticyclones interacted with the Brazil Current, instabilizing it, forming dipoles with the current cyclonic meanders, leading to their downstream propagation. Ancienter cyclonic eddies within Santos Basin may interfere with the propagation of the large anticyclones further south. In addition, the continuous arrival of remotely-originated anticyclones, the larger portion over the São Paulo Plateau presented a tendency of counter-clockwise circulation during the whole cruise period.

https://doi.org/10.1590/2675-2824071.2206icas

15.

Amblyopic patient adherence under patching treatment
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Tavares, Mayo Kayann Guerra Silva

; Isaac, Cassiano Rodrigues

; Cruz, Rodrigo Machado

; Lourenço, Adriana Sobral

; Éckeli, Lorenna Cristina de Oliveira

; Lima, Núbia Vanessa A.

Revista Brasileira de Oftalmologia

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2023, Volume 82 elocation e0003

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To evaluate the effectiveness of text messaging in improving adherence to occlusion therapy for amblyopia. The secondary objective was to correlate the responses given in a self-reporting questionnaire with treatment outcome (improvement in visual acuity). Methods: This is a prospective, randomized, blinded clinical trial. The patients’ parents or legal guardians in the intervention group received text messages reminding them of the importance of patching. The control group received no text messages. At final evaluation, after a period of three to six months, the patients’ parents or legal guardians answered a self-reporting questionnaire to evaluate adherence to treatment. Results: The study included 34 patients with an average age of 5.35 years, 20 in the intervention group and 14 in the control group. According to the results of the self-reporting questionnaire, 50% of the study population was considered as having low adherence to treatment, 29% as having medium adherence, and 21% as having good adherence. There was no significant difference between trial groups. The comparison between an improvement in visual acuity and the mean value obtained in the self-reporting questionnaire showed a significant association between this improvement and adherence to treatment (p=0.03). Conclusion: The present study did not find a correlation between text messaging and an improvement in adherence to occlusion therapy, as shown by previous studies for different treatments. A statistically significant association was identified between an improvement in visual acuity and a good therapeutic adherence, as measured by the self-reporting questionnaire. This finding allows us to recommend using a self-reporting questionnaire as a simple method to measure adherence to treatment and help decisions about therapeutic strategies to be adopted in the patient's continuing treatment.

RESUMO Objetivo: Avaliar a eficácia do envio de mensagens de texto na melhora da adesão ao tratamento oclusivo da ambliopia. O objetivo secundário foi correlacionar as respostas dadas no questionário autorreportado e os resultados obtidos no tratamento (melhora da acuidade visual). Métodos: Ensaio clínico prospectivo, mascarado e randomizado. Os pais ou responsáveis legais dos pacientes no grupo intervenção receberam mensagens de texto para lembrar a importância dos oclusores. O grupo controle não recebeu mensagens. Na avaliação geral após 3 a 6 meses, os responsáveis responderam a um questionário autorreportado para avaliar a aderência ao tratamento. Resultados: Foram incluídos 34 pacientes com idade média de 5,35 anos; 20 eram do grupo intervenção. A população do estudo foi considerada 50% pouco aderente ao tratamento, 29% com aderência média e 21% com boa aderência, de acordo com resultado do questionário autorreportado. Não houve diferença significativa entre os grupos estudados. Quando comparada a relação entre a melhora da acuidade visual com o valor médio do questionário autorreportado, foi observada associação significativa da melhora com a adesão ao tratamento (p=0,03). Conclusão: Este estudo não mostrou melhora da aderência ao tratamento oclusivo com o envio de mensagens de texto, como tinha sido observado em estudos anteriores para outros tratamentos. Foi identificada uma relação estatisticamente significativa entre a melhora na acuidade visual e boa aderência terapêutica medida pelo questionário autorreportado. Isso permite recomendar o uso do questionário autorreportado como uma forma simples de mensurar aderência ao tratamento e auxiliar nas decisões sobre estratégias a serem adotadas na continuidade do seguimento do paciente.

https://doi.org/10.37039/1982.8551.20230003

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