Abstract The purpose of this research was to evaluate HSYA’ effects and mechanisms to improve Scars Induced by Anticoagulant Injection by vivo and vitro study. New Zealand rabbits were divided into Normal control (NC), Anticoagulant, Anticoagulant+HSYA-Low, Anticoagulant+HSYA-Middle and Anticoagulant+HSYA-High. Measuring TGF-β1 and IL-1β concentration by Elisa assay; evaluating pathology and fibrosis level by HE and Masson staining, measuring collage I, collage III, TLR4 and NF-κB(p65) protein expression by IHC assay. Relative gene expression (Collage I, Collage III, TLR4 and NF-κB(p65)) were evaluated by RT-qPCR assay. Relative proteins expression (Collage I, Collage III, TLR4 and NF-κB(p65)) were evaluated by WB assay. And using TGF-β1 to stimulate cell to make cell model. Compared with NC group, TGF-β1 and IL-1β concentration were significantly increased (P < 0.001); The pathology and fibrosis level were significantly deteriorated, meanwhile, Collage I, Collage III, TLR4 and NF-κB(p65) proteins and gene expression were significantly up-regulation in Anticoagulant group (P < 0.001). With HSYA supplement, TGF-β1 and IL-1β concentration were significantly depressed, Pathology and fibrosis levels were significantly improved, Collage I, Collage III, TLR4 and NF-κB(p65) proteins and gene expressions were significantly improved with dose-dependent (P < 0.05). HSYA could improve anticoagulant injury induced subcutaneous scar via regulation TLR4/NF-κB(p65).

ABSTRACT Mastering accurate spatial planting and distribution status of the crops is significantly important for the nation to guide the agricultural production and formulate agricultural policies from a macro perspective. In this paper, the Landsat-8 OLI satellite images were taken as the data sources. And as for the nine crop types within the study area, such as the wheat, rice, and other crops, three classification methods of the random forest classification (RFC), the support vector machine (SVM), and the maximum likelihood classification (MLC) were applied in extracting the planting area of winter wheat in Wushi County of Xinjiang Uygur Autonomous Region. It can be seen from the results that, general classification accuracy of MLC, SVM, and RFC are respectively 80.58%, 87.95%, and 95.96%, while their Kappa coefficients are respectively 0.61, 0.76, and 0.86. The RFC method shows higher classification accuracy that those of MLC and SVM methods. The principal component analysis (PCA) was carried out on the original 7-band image to extract the first 4 principal components and calculate the normalized difference vegetation index (NDVI), enhanced vegetation index (EVI), wide dynamic range vegetation index (WDRVI), and normalized difference water index (NDWI). Meanwhile, the 6 additional auxiliary feature bands were superimposed on the original 7-band images to carry out reclassification, through which, the general accuracy of MLC increased by 3 percent while its Kappa coefficient increased by 0.06; the SVM general accuracy increased by 3.02 percent while its Kappa coefficient increased by 0.13; and the general accuracy of the RFC increased by 0.85 percent while its Kappa coefficient increased by 0.02. This indicates that, the adding of auxiliary information can improve the crop classification and identification ability and accuracy. Based on the comprehensive evaluation, the classification method of random forest is proved to have better performance in winter wheat identification.

RESUMO OBJETIVO O estresse psicológico é um importante problema de saúde mental entre estudantes universitários. O objetivo deste estudo foi determinar o estresse psicológico e seus fatores de risco associados entre os estudantes na província de Anhui. MÉTODOS Um estudo transversal foi realizado entre uma amostra de 1.304 indivíduos. Nesse estudo, foi preenchido um questionário autoaplicável que consiste na demografia geral e no Questionário Geral de Saúde (GHQ-12). O problema psicológico foi avaliado utilizando o questionário GHQ de 12 itens. Uma divisão dicotômica de categoria foi imposta ao GHQ-12 para efeito de análise. Uma pontuação de quatro ou mais no GHQ-12 mostrava que um indivíduo tem problemas psicológicos. Os dados foram analisados pelo software SPSS 20.0. RESULTADOS Um total de 1.304 amostras foi analisado neste estudo. Os resultados indicaram que o nível de educação do pai e da mãe estava associado com estudantes em estresse psicológico (P<0,001). Foi encontrada uma associação significativa entre o exercício de alta intensidade e o exercício de baixa intensidade com o estresse psicológico. No entanto, não foi identificada qualquer diferença significativa entre o gênero e o estresse psicológico (P=0,173). CONCLUSÃO O nível de educação dos pais, exercícios de alta intensidade e exercícios de baixa intensidade foram associados com estresse psicológico. Nossos resultados sugerem que é indispensável aumentar a sensibilização para as perturbações psicológicas e para os fatores de risco associados aos estudantes universitários. São necessários mais estudos para desenvolver intervenções adequadas para grupos de alto risco.

SUMMARY OBJECTIVE Psychological distress is an important mental health problem among university students. The goal of this study was to determine psychological distress and its associated risk factors among students in the Anhui province. METHODS A cross-sectional study was conducted in a sample of 1304 students. In this study, a self-administered questionnaire consisting of the general demography and General Health Questionnaire (GHQ-12) was completed. Psychological distress was assessed using the GHQ-12-item questionnaire. A dichotomous category split was imposed on the GHQ-12 for the purpose of analysis. A GHQ-12 score of 4 or higher indicated psychological distress. The data were analyzed by SPSS 20.0 system. RESULTS A total of 1304 samples were analyzed in this study. The results indicated that the education level of the father and mother was associated with the students’ psychological distress (P<0.001). A significant association was found between high-intensity exercise and low-intensity exercise and psychological distress. However, no significant difference was identified between gender and psychological distress (P=0.173). CONCLUSION The education level of parents, high-intensity exercise, and low-intensity exercise were associated with psychological distress. Our results suggest that it is indispensable to raise awareness of psychological disorders and its associated risk factors among university students. Further studies are required to develop appropriate interventions for high-risk groups.

Abstract This paper studies the stiffening effects of the material strain rate sensitivity and strain hardening on the saturated impulse of elastic, perfectly plastic plates. Finite element (FE) code ABAQUS is employed to simulate the elastoplastic response of square plates under rectangular pressure pulse. Rigid-plastic analyses for saturated impulse, which consider strain rate sensitivity and strain hardening, are conducted. Satisfactory agreement between the finite element models (FEM) and predictions of the rigid-plastic analysis is obtained, which verifies that the proposed rigid-plastic methods are effective to solve the problem including strain rate sensitivity and strain hardening. The quantitative results for the scale effect of the strain rate sensitivity are given. The results for the stiffening effects suggest that two general stiffening factors n 1 and n 2, which characterizes the strain rate sensitivity and strain hardening effect, respectively can be defined. The saturated displacement is inversely proportional to the stiffening factors (i.e. n 1 and n 2) and saturated impulse is inversely proportional to the square roots of the stiffening factors (i.e. n 1 and n 2). Formulae for displacement and saturated impulse are proposed based on the empirical analysis.

ABSTRACT: In order to investigate the immune enhancement effects of Ophiopogon japonicus polysaccharide Ophiopogon japonicus (OJPS) on Newcastle disease (ND) live vaccine, chickens vaccinated against ND live vaccine was orally administered with the OJPS at high, medium and low concentrations respectively. In negative control group, chickens were given orally equal volume of physiological saline. On day 14, 21 and 28, the serum antibody titer, erythrocyte-C3b receptor rosette rate (E-C3bRR), erythrocyte-C3b immune complex rosette rate (E-ICRR) and peripheral lymphocyte proliferation were measured. The results showed that at most time points, the antibody titer, peripheral lymphocyte proliferation, E-C3bRR and elimination rate of immune complex of three OJPS administrating groups were significantly higher (P<0.05) than those in negative control group. It indicated that OJPS could significantly improve the immune efficacy of Newcastle disease live vaccine, Ophiopogon japonicus polysaccharide possessed synergistical immunoenhancement.

ABSTRACT: In this paper, we develop a parametric model method and simulate the deployment mechanism of inflatable antenna structures. Different folded methods are developed for the primary members of inflatable antenna structures, which include inflatable tubes, an inflatable torus, a reflector etc. The unstressed configuration and the folded configuration of these members are modeled parametrically using the developed folded methods. A simulation software is developed for the deployment mechanism of inflatable structures by the improved spring-mass system. The driving forces in the deployment process, i.e. the gas pressure and the moment of the fold hinges, are analyzed for each member. During the development process, self-contact or collision with the membrane occurs. A rule for identifying self-contact elements is applied, and a penalty function method is developed to solve this challenging problem. Finally, the equation of motion is solved using finite difference method. The developed simulation software is validated by simulating a cylindrical inflatable tube that is folded in half, and the simulation agrees well with the experiment. The deployment mechanism of the antenna model similar to that for the Inflatable Antenna Experiment (IAE) is modeled, analyzed and estimated. The deployed configurations and the dynamic parameters of each node are obtained. The numerical simulation results show that the simulation software for the deployment mechanism can correctly predict the deployment process of inflatable antenna structures.

Este trabalho apresenta uma investigação do desempenho dos métodos de detecção e correção de perdas de ciclos: Turbo Edit (TE), Melbourne-Wübbena banda larga (MWWL) e forward and backward moving window averaging (FBMWA). Os métodos TE e MWWL foram combinados com a taxa de variação do conteúdo total de elétrons presentes na ionosfera (TECR) e o FBMWA com Second-order Time-difference Phase Ionosphere Residual (STPIR) e TECR. Sob diferentes cenários, dados GPS de 10 estações são utilizados para avaliar o desempenho dos métodos para detecção de perdas de ciclos. O MWWL-TECR apresentou o melhor desempenho na detecção das perdas de ciclo para dados com taxa de observação de 1 s. As comparações relativas mostram que o método FBMWA-TECR apresenta melhores resultados em relação com a versão original FBMWA-STPIR em que a taxa de detecção foi de 100% e 73%, respectivamente. Para dados com taxa de amostragem de 5 s, o FBMWA-TECR apresentou melhor desempenho do que MWWL-TECR. No entanto, o FBMWA é adequado apenas para pós-processamento, que se refere a aplicações em que os dados GPS são processados após o rastreio.

In this work, we assessed the performance of the cycle-slip detection methods: Turbo Edit (TE), Melbourne-Wübbena wide-lane ambiguity (MWWL) and forward and backward moving window averaging (FBMWA). The TE and MWWL methods were combined with ionospheric total electron content rate (TECR), and the FBMWA with second-order time-difference phase ionosphere residual (STPIR) and TECR. Under different scenarios, 10 Global Positioning System (GPS) datasets were used to assess the performance of the methods for cycle-slip detection. The MWWL-TECR delivered the best performance in detecting cycle-slips for 1 s data. The relative comparisons show that the FBMWA-TECR method performed slightly better than its original version, FBMWA-STPIR, detecting 100% and 73%, respectively. For data with a sample rate of 5 s, the FBMWA-TECR performed better than MWWL-TECR. However, the FBMWA is suitable only for post-processing, which refers to applications where the data are processed after the fact.

ABSTRACT: For a small country with limited research budget and lack of advanced space technology, it is imperative to find new approaches for the development of low-cost launch vehicles (LV), which is, among all possibilities, an interesting option for rapid access to space, focused on integration of acquired components complemented with indigenously developed subsystems. This approach requires the cooperation of developed countries with huge experience and knowledge in LV development and operations. The main objective is to develop a small three stage solid propellant LV capable of delivering a payload of 100 kg to a circular low earth orbit of 600 km altitude, with the first and second stage solid rocket motors (SRM) hypothetically acquired from different countries and the third one designed and produced domestically in accordance with the production and technological capability. This approach provides main advantages such as: reduction in total time to access the space and to master the basic knowledge of launch operations. For this purpose, an integer continuous genetic algorithm global optimization method was selected and implemented, the SRM characteristics of the first and second stage were considered as integer variables, whereas the design variables of the third stage SRM and the trajectory variable were considered as continuous. A multi discipline feasible (MDF) framework was implemented along with the propulsion, aerodynamic, mass and trajectory models. Despite their particular characteristics and constraints, the results show highly acceptable values, and the approach proved to be reliable for conceptual design level.

Com a primeira fase do Sistema COMPASS/BeiDou-2 (BDS) finalizada, este trabalho analisa e apresenta uma avaliação do desempenho do posicionamento e caracterização do BDS. O principal objetivo deste trabalho é comparar o desempenho do BDS em relação ao GPS em termos de acurácia (posicionamento estático e cinemático), Diluição da Precisão (Dilution of Precision - DOP, i.e., HDOP e VDOP), e visibilidade e qualidade das medidas para os satélites GEO, IGSO e MEO do BDS. Para alcançar este objetivo, coletou-se as pseudodistâncias e medidas de fase da onda portadora, modulada em B1 e B2, em uma estação localizada em Xangai durante o período de 00:00 até 24:00 no dia 28 de dezembro de 2012. Estimou-se uma linha de base curta através de medidas de fase da onda portadora durante um período de 24 horas com 48 segmentos de observações (a duração de cada segmento foi de aproximadamente 30 minutos). Os resultados do posicionamento cinemático foram obtidos a partir da dupla diferença de fase com as ambiguidades fixadas através da injunção de uma linha de base curta (precisa). De forma geral, os resultados das analises do posicionamento relativo estático mostram que o BDS alcança uma acurácia ao nível do milímetro o que é equivalente ao GPS. No caso do posicionamento cinemático, uma acurácia centimétrica é alcançada mostrando que o desempenho do BDS é melhor para a componente este, entretanto, o contrário para as outras componentes, i.e., oeste e vertical. Assim, pode-se concluir que para um pior cenário, a acurácia do BDS coincide com a do GPS ao nível do centímetro. No entanto, mais experimentos devem ser conduzidos para avaliar a qualidade do BDS sobre a região da Ásia-Pacífico, e.g., Austrália.

With the first phase of COMPASS/BeiDou-2 (BDS) completed, the assessment of positioning performance and the characterization of its system are analyzed and presented. Pseudo-range and carrier phase measurements modulated on B1 and B2 have been collected in Shanghai, from 00:00 to 24:00 on 28 December, 2012. Compared with GPS, visibility and measurement quality of BDS's GEO, IGSO and MEO satellites are analyzed. DOP during the whole orbital period is also analyzed the results demonstrate that BDS's HDOP is better than GPS's one, but VDOP opposite. Furthermore, the result of positioning is also presented and analyzed. Short baselines are estimated by standalone BDS and GPS's carrier phase measurement, respectively, using 48 segmentations of observations during a whole day (24 hours, each segmentation, is about 30 minutes observation). The analysis of static relative positioning demonstrates that BDS could achieve to millimeter level, corresponding to GPS. Kinematic result is produced by double differenced carrier phase observations with the ambiguities fixed under the constraint of precise short baseline.The result shows that the centimeter accuracy could be achieved. When comparing the results of kinematic baseline solutions, performance of BDS is worse than GPS on North and Up components, but oppositely on the component of East in the kinematic baseline processing.

ABSTRACT: In this paper, a multidisciplinary design optimization (MDO) approach of a solid propellant kick rocket motor is considered. A genetic algorithm optimization method has been used. The optimized kick solid rocket motor (KSRM) is capable of delivering a small satellite of 200 kg to a circular low earth orbit (LEO) of 600 km altitude. The KSRM should accelerate from the initial apogee velocity of 5000 m/s up to the orbital insertion velocity of 7560 m/s. The KSRM design variables and the orbital insertion trajectory profile variables were optimized simultaneously, whereas the mass characteristics of the payload deployment module were assigned. A depleted shutdown condition was considered, to avoid the necessity of a thrust termination device, resulting in a reduced total mass of the KSRM. The results show that the proposed optimization approach was able to find the convergence of the optimal solution with highly acceptable value for conceptual design phase.

Sm-Co/Fe, hard/soft magnetic bilayers have been fabricated on 70 nm Cr buffered Si (100) substrate by dc and rf magnetron sputtering and annealed at 525O C for 30min. Very thin Mo layers (0-0.7 nm) were introduced between Sm-Co and Fe layers. The samples were analyzed by X-Ray Diffraction (XRD) and Alternating Gradient Magnetometer (AGM). All of the samples showed strong exchange coupling between hard and soft magnetic phases. Magnetization, coercivity and energy product (BH)max suggest a sinusoidal behavior. The energy product was found increased to 45% for 0.3 nm Mo interlayer as compared to sample without Mo layer.