Pesquisa | SciELO

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000122

Performatividad educativa y espacio biográfico en educación superior: el régimen discursivo neoliberal
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Baquero Másmela, Pedro

; Martínez Posada, Jorge E.

Nómadas

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Dez 2022, Volume 56 Páginas 15 - 33

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen El artículo recoge algunos aspectos de la investigación doctoral "Performatividad y cuerpos docentes en educación superior: una aproximación desde el espacio biográfico", llevada a cabo en el marco del Doctorado en Estudios Sociales de la Universidad Distrital Francisco José de Caldas. La problemática que se aborda es el estudio de los recursos de gubernamentalidad de la universidad contemporánea bajo el régimen performativo neoliberal. En este sentido, la investigación revisa el concepto de performatividad educativa y lo aplica al estudio de diferentes recursos de gestión y mercantilización de la universidad y a su proyección en las subjetividades de profesores, investigadores y otros actores universitarios.

Abstract The article gathers some aspects of the doctoral research "Performativity and teaching bodies in higher education: an approach from the biographical space", carried out in the Doctorate in Social Studies program of the Universidad Distrital Francisco José de Caldas. The study of governmentality resources of contemporary university under the neoliberal performative regime was addressed. In this regard, the research reviews the concept of educational performativity and applies it to the study of different management and commercialization resources of the university and its projection in the subjectivities of professors, researchers and other university actors.

Resumo O artigo coleta alguns aspectos da investigação doutorai "Performatividade e corpos docentes em educação superior: uma aproximação desde o espaço biográfico", conduzida no marco do Doutorado em Estudos Sociais da Universidade Distrital Francisco José de Caldas. A problemática abordada é o estudo dos recursos de governamentalidade da universidade contemporânea sob o regime performativo neoliberal. Neste sentido, a pesquisa revisa o conceito de performatividade educativa e o aplica ao estudo de diferentes recursos de gestão e mercantilização da universidade, e a sua projeção nas subjetividades de professores, pesquisadores e outros atores universitários.

https://doi.org/10.30578/nomadas.n56a1

In vitro propagation from nodal segments of Lippia origanoides (chemotype A)
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Moreno, Julián Sebastián Ramírez

; Porras, Sergio Andrés Vega

; Escobar, Roosevelt Humberto

; Stashenko, Elena E.

; Lorenzo, Jorge Luis Fuentes

; Gutiérrez, Luz Nayibe Garzón

Ciência Rural

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2022, Volume 52 Nº 7 elocation e20210323

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Esta pesquisa descreve um protocolo de micropropagação eficiente para Lippia origanoides (Verbenaceae). Sementes estéreis foram utilizadas para a obtenção de mudas germinadas em meio Murashige e Skoog (MS) suplementado com sacarose e ágar. Os segmentos nodais obtidos das mudas foram cultivados em meio MS, suplementado com diferentes concentrações de ácido giberélico (GA), benzilaminopurina (BAP) e ácido 1-naftalenacético (ANA) com BAP. Foram analisados a indução de calo, comprimento de brotação, número de brotação e comprimento de raiz. Os tratamentos mostraram alta porcentagem de formação de calo com 0,5 a 1,5 mg L-1 de BAP sozinho ou em combinação com ANA (0,1 mg L-1). O maior valor de número de brotações por segmento nodal foi obtido com 1,5 mg L-1 de BAP (4,3 ± 0,8). As mudas obtidas apresentaram melhor enraizamento in vitro na ausência de reguladores de crescimento vegetal (PGRs) e demonstraram taxa de aclimatação de 90%. Contudo, relata-se um protocolo para propagação in vitro e aclimatação de L. origanoides para quimiotipos A da Colômbia.

ABSTRACT: This research described an efficient micropropagation protocol for Lippia origanoides (Verbenaceae). Sterile seeds were used to obtain germinated seedlings in Murashige and Skoog medium (MS) supplemented with sucrose and agar. The nodal segments obtained from seedlings were grown on MS medium supplemented with different concentrations of gibberellic acid (GA), benzylaminopurine (BAP) and 1-naphthalenacetic acid (NAA) with BAP. The callus induction, shoots length, shoots number and root length, were analyzed. The treatments showed high percentage of callus formation at 0.5 to 1.5 mg L-1 of BAP alone or in combination with NAA (0.1 mg L-1). The highest value of shoot number per nodal segments was obtained at 1.5 mg L-1 of BAP (4.3 ± 0.8). The obtained plantlets were better rooted in vitro in the absence of plant growth regulators (PGRs) and they showed acclimatization rate of 90%. We reported a protocol for in vitro propagation and acclimatization of L. origanoides for A chemotypes from Colombia.

https://doi.org/10.1590/0103-8478cr20210323

Microbiological quality and presence of foodborne pathogens in fresh-squeezed orange juice samples purchased from street vendors and hygienic practices in Morelia, Mexico
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DOMINGUEZ-GONZALEZ, Karla Gabriela

; AGUILAR-CHAIREZ, Salvador

; CERNA-CORTES, Joel

; SORIA-HERRERA, Ricardo Jiovanni

; CERNA-CORTES, Jorge Francisco

Food Science and Technology

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2022, Volume 42 elocation e10222

Resumo: En | Texto: En | PDF: En

Abstract Few studies have screened fresh orange juice for the presence of foodborne pathogens. This study therefore evaluated the microbiological quality and occurrence of Salmonella, Shigella, Escherichia coli, and diarrheagenic E. coli pathotypes (DEP) in fresh-squeezed orange juice purchased from street vendors in Morelia, Michoacan, Mexico. The general hygienic practices of street vendors were poor. All 100 samples analyzed were positive for aerobic mesophilic bacteria, with concentrations ranging from 2.41 to 6.03 log CFU/mL. A total of 90 (90%), 35 (35%), and 14 (14%) samples were positive for total coliforms, fecal coliforms, and E. coli, respectively, present with concentrations ranging from < 1 to 4.84 log CFU/mL, < 3 to > 1,100 MPN/mL, and < 3 to 210 MPN/mL, respectively. Salmonella was not detected in any of the samples, whereas Shigella sonnei was isolated from one sample. Two samples were positive for DEP; one harbored ETEC strains and the other STEC strains. Our results highlight the elevated risk for consumer health associated with the ingestion of fresh-squeezed orange juice.

https://doi.org/10.1590/fst.10222

In Mexico City, fresh-squeezed street-vended orange juice is contaminated with fecal coliforms, Escherichia coli, and Shiga toxin-producing E. coli: A potential risk for acquiring foodborne diseases
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FIGUEROA-DUCOING, Belem Karina

; CARRILLO-SANCHEZ, Alma Karina

; RIVERA-GUTIERREZ, Sandra

; RIOS-MUÑIZ, Diana

; ESTRADA-GARCIA, Teresa

; CERNA-CORTES, Jorge Francisco

Food Science and Technology

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2022, Volume 42 elocation e52022

Resumo: En | Texto: En | PDF: En

Abstract This study evaluated the microbiological quality and prevalence of Escherichia coli and diarrheagenic E. coli pathotypes (DEP) among fresh-squeezed orange juice from street vendors and their hygienic practices. Sixty orange juice stalls in Mexico City were visited, and 60 samples were purchased. Most (65%) of the street vendors had poor hygienic practices. Twelve (20%) prepared orange juice at the time of purchase, while the other stalls sold already-squeezed orange juice. All samples analyzed were positive for aerobic mesophilic bacteria, with limits ranging from 1 to 6.8 log CFU/mL. A total of 35 (58.3%), 27 (45%), and 5 (8.3%) samples were positive for total coliforms, fecal coliforms, and E. coli, respectively, present at concentrations ranging from < 3 to > 1100, < 3 to > 1100, and < 3 to 53 MPN/mL, respectively. Two samples harbored DEP at concentrations of 3.6 and 9.2 MPN/mL. Both samples harbored Shiga toxin-producing E. coli strains, positive for the Shiga toxin 2 (stx2) locus. Our results suggest that consumption of fresh-squeezed street-vended orange juice may pose a health risk for consumers, revealing the necessity to implement adequate hygiene and safety practices to protect the health of consumers.

https://doi.org/10.1590/fst.52022

Occurrence of tick-borne pathogens in dogs in a coastal region of the state of Ceará, northeastern Brazil
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Fonsêca, Arícia Débora Vasconcelos

; Oliveira, Lorena Mayana Beserra de

; Jorge, Felipe Rodrigues

; Cavalcante, Ramuelly Olinda

; Bevilaqua, Claudia Maria Leal

; Pinto, Francisco José Maia

; Santos, Jessica Maria Leite dos

; Teixeira, Bruno Marques

; Rodrigues, Ana Kétylla Ponte Prado

; Braz, Gissandra Farias

; Viana, Geysa Almeida

; Costa, Edmara Chaves

; Serpa, Maria Carolina de Azevedo

; Weck, Bárbara Conte

; Labruna, Marcelo Bahia

Revista Brasileira de Parasitologia Veterinária

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2022, Volume 31 Nº 1 elocation e021321

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi determinar a ocorrência de patógenos transmitidos por carrapatos (Ehrlichia canis, Babesia vogeli, Hepatozoon spp. e Rickettsia spp.) em cães na Vila de Jericoacoara, região costeira do Ceará, Brasil. Amostras de sangue foram coletadas de 153 animais e analisadas por métodos moleculares e sorológicos. Sessenta animais foram encontrados infectados ou expostos a pelo menos a um dos patógenos estudados. Babesia vogeli foi o patógeno mais prevalente (15%), seguido por E. canis (13,7%) e Hepatozoon spp. (11,8%), que foi identificado como Hepatozoon canis por sequenciamento. Vinte cães (13%) foram sororreativos à Rickettsia spp. Rhipicephalus sanguineus sensu lato foi observado em 11,8% dos animais. Houve associações entre idade (<3 anos) e positividade para B. vogeli, e entre habitação (cães de rua) e positividade para H. canis. Também houve associações entre anemia e infecção por H. canis, e entre leucopenia e exposição a Rickettsia spp. Não foi detectada associação entre alterações clínicas e infecção ou exposição aos patógenos estudados. Os resultados confirmaram que patógenos de importância veterinária estão circulando no nordeste do Brasil e mostraram que cães estão expostos a espécies de Rickettsia com potencial zoonótico, indicando a necessidade de medidas de controle do vetor.

Abstract The aim of this study was to determine the occurrence of tick-borne pathogens (Ehrlichia canis, Babesia vogeli, Hepatozoon spp. and Rickettsia spp.) in dogs in Vila de Jericoacoara, coastal region of Ceará, Brazil. Blood samples were collected from 153 animals and analyzed using molecular and serological methods. Sixty animals were found to be infected or exposed to at least one of the pathogens studied. Babesia vogeli was the most prevalent pathogen (15%), followed by E. canis (13.7%) and Hepatozoon spp. (11.8%), which was identified as Hepatozoon canis through sequencing. Twenty dogs (13%) were seroreactive to Rickettsia spp. Rhipicephalus sanguineus sensu lato was observed on 11.8% of the animals. There were associations between age (< 3 years old) and positivity for B. vogeli, and between habitation (stray dogs) and positivity for H. canis. There were also associations between anemia and infection with H. canis, and between leukopenia and exposure to Rickettsia spp. No association was detected between clinical alterations and infection with or exposure to the pathogens studied. The results confirmed that pathogens of veterinary importance are circulating in northeastern Brazil and showed that dogs are exposed to Rickettsia species with zoonotic potential, thus indicating a need for vector control measures.

https://doi.org/10.1590/s1984-29612022010

Guía de práctica clínica mexicana para el diagnóstico y tratamiento de las dislipidemias y enfermedad cardiovascular aterosclerótica
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Pavía-López, Abel A.

; Alcocer-Gamba, Marco A.

; Ruiz-Gastelum, Edith D.

; Mayorga-Butrón, José L.

; Mehta, Roopa

; Díaz-Aragón, Filiberto A.

; Aldrete-Velasco, Jorge A.

; López-Juárez, Nitzia

; Cruz-Bautista, Ivette

; Chávez-Mendoza, Adolfo

; Secchi-Nicolás, Nikos C.

; Guerrero-Martínez, Francisco J.

; Cossio-Aranda, Jorge E.

; Mendoza-Zubieta, Victoria

; Fanghänel-Salmon, Guillermo

; Valdivia-Proa, Martha

; Olmos-Domínguez, Luis

; Aguilar-Salinas, Carlos A.

; Dávila-Maldonado, Luis

; Vázquez-Rangel, Armando

; Pavia-Aubry, Vanina

; Nava-Hernández, María de los A.

; Hinojosa-Becerril, Carlos A.

; Anda-Garay, Juan C.

; Ríos-Ibarra, Manuel O. de los

; Berni-Betancourt, Ana C.

; López-Cuellar, Julio

; Araiza-Garaygordobil, Diego

; Rivera-Reyes, Romina

; Borrayo-Sánchez, Gabriela

; Tapia-Hernández, Mónica

; Cano-Nigenda, Claudia V.

; Guerra-López, Arturo

; Elías-López, Josué

; Figueroa-Morales, Marco A.

; Montaño-Velázquez, Bertha B.

; Velasco-Hidalgo, Liliana

; Rodríguez-Lozano, Ana L.

; Pimentel-Hernández, Claudia

; Baquero-Hoyos, María M.

; Romero-Moreno, Felipe

; Rodríguez-Vega, Mario

Archivos de cardiología de México

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2022, Volume 92 Supl. 1 Páginas 1 - 62

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Background: Cardiovascular diseases are the leading cause of mortality worldwide and Mexico is no exception. The epidemiological data obtained in 1990 showed that cardiovascular diseases represented 19.8% of all causes of death in our country. This figure increased significantly to 25.5% for 2015. Some national surveys suggest that more than 60% of the adult population has at least one risk factor for cardiovascular disease (obesity or overweight, hypertension, smoking, diabetes, dyslipidemias). On the other hand, data from the Pan American Health Organization have linked the process of atherosclerosis as the first cause of premature death, significantly reducing life expectancy, which has enormous social repercussions. Objective: This document constitutes the Clinical Practice Guide (CPG) prepared at the initiative of the Mexican Society of Cardiology in collaboration with the Mexican Society of Nutrition and Endocrinology, AC, National Association of Cardiologists of Mexico, AC, Mexican Association for the Prevention of Atherosclerosis and its Complications, AC, National Normative Committee of General Medicine, AC, National College of Geriatric Medicine, AC, College of Internal Medicine of Mexico, AC, Mexican Society of Angiology and Vascular and Endovenous Surgery, AC, Mexican Institute of Research Nephrological, AC and the Mexican Academy of Neurology, A.C.; with the methodological support of the Ibero-American Agency for the Development and Evaluation of Health Technologies, in order to establish recommendations based on the best available evidence and agreed upon by an interdisciplinary group of experts. The objective of this document is to provide evidence-based recommendations to help decision makers in the diagnosis and treatment of dyslipidemias in our country. Material and methods: This document complies with international quality standards, such as those described by the Institute of Medicine of the USA, the Institute of Clinical Excellence of Great Britain, the Scottish Intercollegiate Guideline Network and the Guidelines International Network. A multidisciplinary group of clinical experts and methodologists with experience in systematic reviews of the literature and the development of clinical practice guidelines was formed. A scope document was agreed upon, relevant clinical questions were established, the best available evidence critically evaluated in systematic literature reviews was exhaustively identified, and clinical recommendations were developed. The modified Delphi Panel methodology was used to achieve an adequate level of consensus in each of the recommendations contained in this CPG. Results: 23 clinical questions were agreed upon which gave rise to their respective clinical recommendations. Conclusions: We consider that this document contributes to better clinical decision-making and becomes a point of reference for clinicians and patients in the management of dyslipidemias and this contributes to reducing the morbidity and mortality derived from atherosclerotic cardiovascular events in our country.

https://doi.org/10.24875/acm.m22000081 1458 downloads

Me preparo para prevenir la violencia y el acoso en estudiantes de medicina en México
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Olivares Olivares, Silvia Lizett

; Gómez Zapata, José Francisco

; Flores Félix, Cinthya Margarita

; Castañeda Prado, Andrés

; Turrubiates Corolla, Miriam Lizzeth

; Esperón Hernández, Ramón Ignacio

; Valdez-García, Jorge E.

Investigación en educación médica

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Dez 2021, Volume 10 Nº 40 Páginas 86 - 96

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The abuse and harassment of medical students is an issue that requires attention and prevention. Various studies demonstrate the need to create a safe learning environment inside and outside educational institutions throughout the program, including clinical settings and social service. A national survey distributed in February 2021 by the Mexican Association of Physicians in Training AMMEF (by its acronym in Spanish) and the Association of Mexican Faculties and Schools of Medicine AMFEM (by its acronym in Spanish) reached 2,458 students from the public (74.4%) and private (25.6%) universities. The last section included questions related to violence and harassment. As a result, 40% of the participants reported experiencing sexual harassment or violence during their medical training. Four actions are recommended to prevent and address the conditions of violence and harassment: 1) Have orientation for the academic community on the types of violence, 2) Have reliable reporting channels, 3) Have mentoring throughout the program, 4) Have academic societies. These actions intend to establish protocols and support networks so that students have mechanisms for self-care and reporting situations that endanger their physical and emotional health. Likewise, the recommendations presented here seek to promote standards to be included in the affiliation and accreditation reference frameworks as part of the Incremental Quality Model. There is no reason to wait to take care of the most valuable asset in medical schools: the students.

Resumen El maltrato y acoso en estudiantes de medicina es un tema que requiere atención y prevención. Diversos estudios demuestran la necesidad de crear un ambiente de formación seguro dentro y fuera de las instituciones educativas a lo largo del programa, incluyendo escenarios clínicos y el servicio social. Una encuesta nacional distribuida en febrero de 2021 por la Asociación Mexicana de Médicos en Formación (AMMEF) y la Asociación Mexicana de Facultades y Escuelas de Medicina (AMFEM) llegó a 2,458 estudiantes de universidades públicas (74.4%) y privadas (25.6%). La última sección incluyó preguntas relacionadas con la violencia y el acoso. Como resultado el 40% de los participantes informó haber experimentado acoso sexual o violencia durante su formación médica. Se recomiendan cuatro acciones para empezar a prevenir y atender las condiciones de violencia y acoso: 1) orientar a la comunidad académica de los tipos de violencia, 2) contar con canales de denuncia confiables, 3) contar con mentoría a lo largo del programa, 4) contar con sociedades académicas. La intención de estas acciones es establecer protocolos y redes de soporte para que los alumnos cuenten con mecanismos para el autocuidado y denuncia de situaciones que pongan en peligro su salud física y emocional. Así mismo, las recomendaciones aquí planteadas buscan promover estándares que deben incorporarse en marcos de referencia de afiliación y acreditación como parte del Modelo Incremental de Calidad. No hay razón para esperar a cuidar lo más valioso de las escuelas de medicina: los estudiantes.

https://doi.org/10.22201/fm.20075057e.2021.40.21388 101 downloads

Sarcoma de células dendríticas foliculares. Informe de un caso
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Sosa-Luis, Antonio S.

; Gutiérrez-Quiroz, Claudia T.

; Espinosa-Zúñiga, Francisco

; Meléndez-Mena, Daniel E.

; Montiel-Jarquín, Álvaro J.

; Loría-Castellanos, Jorge

Cirugía y cirujanos

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Ago 2021, Volume 89 Nº 4 Páginas 538 - 541

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Background: Follicular dendritic cell sarcoma is a rare pathology, it occurs mainly in nodal sites such as head, neck, oropharynx, although extranodal presentation such as spleen and liver may occur. In most cases it is asymptomatic but may present general symptoms, abdominal pain or fever. Immunohistochemistry is essential to make a definitive diagnosis. Case presentation: Forty year-old woman, with submaxillary lesion, in the neck, right fronto-parieto-occipital region with dry oral mucosa. It was initially managed as a Sjögren's syndrome ruled out by the histopathological result of salivary gland biopsy. Subsequently, a neck ganglion biopsy was performed that reported follicular dendritic cell sarcoma, with positive immunohistochemical expression for CD23 and negative for CD21 and LCA. It was managed with samarium with a survival of 3 months from the time of its diagnosis. Conclusions: Follicular dendritic cell sarcoma is rare and its global survival is short.

Resumen Antecedentes: El sarcoma de células dendríticas foliculares es una enfermedad rara, caracterizada principalmente en sitios nodales como la cabeza, el cuello y la orofaringe, aunque puede ser extranodal, como en el bazo y el hígado. En la mayoría de los casos cursa asintomática, pero puede presentar síntomas generales, dolor abdominal o fiebre. La inmunohistoquímica es indispensable para llegar a un diagnóstico definitivo. Presentación del caso: Mujer de 40 años, con abultamiento submaxilar en el cuello, región frontoparietooccipital derecha, y sequedad de mucosa oral. Se manejó inicialmente como un síndrome de Sjögren, que fue descartado por el resultado histopatológico de la biopsia de glándula salival. Posteriormente se realizó biopsia de ganglio del cuello, que reportó sarcoma de células dendríticas foliculares con expresión inmunohistoquímica positiva para CD23 y negativa para CD21 y ACL. Se manejó con samario y tuvo una sobrevida de 3 meses desde el diagnóstico. Conclusiones: el sarcoma de células dendríticas foliculares es raro y la sobrevida es corta.

https://doi.org/10.24875/ciru.20000083 42 downloads

10.

Reconstrucción mamaria técnica multiplanar. Descripción de técnica quirúrgica y reporte de caso
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Said-Lemus, Francisco M.

; Téllez-Palacios, Daniela

; Monges-Jones, Jorge E.

Gaceta mexicana de oncología

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2021, Volume 20 Supl. 1 Páginas 138 - 143

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Immediate breast reconstruction procedures are performed when allowed by oncological criteria and patient characteristics, in order to obtain results with adequate volume, shape, projection and conservation of the nipple areola complex. This paper presents a case report and the description of a multiplanar surgical technique (skin, muscle, acellular dermal matrix, dermal flap and fat), which provides a better post-mastectomy skin coverage without compromising the oncologic outcome.

Resumen Los procedimientos de reconstrucción inmediata se realizan cuando el criterio oncológico y las características de la paciente lo permiten, con el objetivo de obtener un resultado con un adecuado volumen, forma, proyección y conservación del complejo areola pezón. Se realiza la descripción de un caso clínico y una técnica quirúrgica multiplanar (piel, músculo, dermis acelular, colgajo autólogo de dermis y grasa) que confiere un mejor contorno de la cubierta cutánea posmastectomía sin comprometer el resultado oncológico.

https://doi.org/10.24875/j.gamo.21000038 17 downloads

11.

Colonic lipomas an uncommon cause of intussusception in adult patients: report of three cases and literature review
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Álvarez-Bautista, Francisco E.

; Moctezuma-Velázquez, Paulina

; Cisneros-Correa, Julio C.

; Aguilar- Frasco, Jorge L.

; Vélez-Valle, Alina

; Vergara-Fernández, Omar

; Salgado-Nesme, Noel

Cirugía y cirujanos

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2021, Volume 89 Supl. 2 Páginas 9 - 12

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Colonic lipomas are infrequent, benign, non-epithelial, fatty neoplasms. Most of the colonic lipomas are asymptomatic, but around 25% of patients may develop symptoms. Nowadays, surgical resection of the involved segment is the treatment of choice. We report three cases of colonic intussusceptions caused by colonic lipomas in adult patients. The patients underwent surgical resection, and the diagnosis was confirmed by histopathological examination of the specimens.

Resumen Los lipomas colónicos son neoplasias benignas, adiposas, no epiteliales poco frecuentes. La mayoría de los lipomas de colon son asintomáticos, pero alrededor del 25% de los pacientes pueden desarrollar síntomas. En la actualidad, la resección quirúrgica del segmento afectado es el tratamiento de elección. Presentamos tres casos de intususcepción intestinal secundaria a lipomas colónicos en pacientes adultos. Los pacientes fueron sometidos a resección quirúrgica y el diagnóstico se confirmó mediante examen histopatológico.

https://doi.org/10.24875/ciru.21000047 17 downloads

12.

Menor Prevalência e Extensão da Aterosclerose Coronária na Doença de Chagas Crônica por Angiotomografia Coronária
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Cardoso, Savio

; Azevedo Filho, Clerio Francisco de

; Fernandes, Fábio

; Ianni, Barbara

; Torreão, Jorge Andion

; Marques, Mateus Diniz

; Ávila, Luiz Francisco Rodrigues de

; Santos Filho, Raul

; Mady, Charles

; Kalil-Filho, Roberto

; Ramires, José Antônio Franchine

; Bittencourt, Marcio Sommer

; Rochitte, Carlos E.

Arquivos Brasileiros de Cardiologia

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Dez 2020, Volume 115 Nº 6 Páginas 1051 - 1060

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Em regiões endêmicas da doença de Chagas, por muitos anos, existe uma observação empírica recorrente de que a doença arterial coronariana (DAC) é incomum em pacientes com doença de Chagas. Estudos anteriores baseados em análise patológica ou angiografia coronária invasiva apresentam resultados controversos. Objetivo Investigar se a DAC é menos prevalente e menos grave em pacientes com doença de Chagas crônica em comparação a uma população pareada controle, com perfil de risco para DAC similar. Métodos Um total de 86 participantes, 43 pacientes com doença de Chagas crônica consecutivos e 43 indivíduos assintomáticos, sem qualquer história prévia de doença cardíaca ou doença DAC conhecida (grupo controle), foram incluídos no estudo. Pacientes e controles foram pareados quanto sexo, idade e escore de risco de Framingham. Todos os pacientes foram analisados quanto ao escore de cálcio coronário (ECC) e submetidos à angiotomografia coronária usando um tomógrafo de 320 detectores. O nível de significância estatística adotado foi de p < 0,05. Resultados O ECC foi significativamente mais baixo em pacientes com doença de Chagas em comparação aos controles (p<0,05). A presença de placas ateroscleróticas coronárias foi significativamente menos frequente em pacientes com doença de Chagas que nos controles (20,9% versus 41,9%, p=0,037). Após ajuste quanto ao escore de Framingham, o odds ratio para a presença de qualquer calcificação coronária foi de 0,26 (IC95%: 0,07-0,99, p=0,048). O padrão é similar para escore de cálcio coronário (ECC) > 10 (OR: 0,11, IC95%: 0,01-0,87, p=0,04), e para a presença de estenose (OR: 0,06, IC95%: 0,01-0,47, p=0,001). O pareamento por escore de propensão também mostrou um efeito da doença de Chagas no ECC (-21,6 pontos no escore absoluto e 25% menos pacientes com ECC > 10; p=0,015). Conclusões A prevalência e a gravidade da DAC são mais baixas nos pacientes com doença de Chagas crônica em comparação a uma população pareada e perfil de risco para DAC similar. (Arq Bras Cardiol. 2020; 115(6):1051-1060)

Abstract Background In Chagas’ disease endemic regions, there has been for many years a recurrent empirical observation that coronary artery disease (CAD) is uncommon in patients with Chagas’ disease. Previous pathological and invasive coronary angiography studies led to controversial results. Objective We sought to investigate whether CAD is less prevalent and less severe in patients with chronic Chagas’ disease when compared with a matched population with a similar CAD risk profile. Methods A total of 86 participants, 43 consecutive patients with chronic Chagas’ disease and 43 asymptomatic individuals, without any prior history of cardiac disease or known CAD (control group), were included. Patients and controls were matched according to gender, age, and Framingham risk score. All participants underwent coronary calcium scoring and coronary computed tomography angiography on a 320-row detector scanner. Statistical significance level adopted was p < 0.05. Results The coronary artery calcium score (CACS) was significantly lower in patients with Chagas’ disease than in controls (p<0.05). The presence of coronary atherosclerotic plaques was significantly less frequent in patients with Chagas’ disease than in controls (20.9% versus 41.9%, p=0.037). After adjustment for the Framingham score, the odds ratio for the presence of any coronary artery calcium (CAC) in Chagas patients was 0.26 (95%CI: 0.07-0.99, p=0.048). The pattern is similar for CACS > 10 (OR: 0.11, 95%CI: 0.01-0.87, p=0.04) and for the presence of any stenosis (OR: 0.06, 95%CI: 0.01-0.47, p=0.001). Propensity score matching also indicated an effect of Chagas disease on the CACS (-21.6 points in the absolute score and 25% less of patients with CACS >10, p=0.015). Conclusions CAD is less prevalent and less severe in patients with chronic Chagas’ disease when compared with a matched population with a similar CAD risk profile. (Arq Bras Cardiol. 2020; 115(6):1051-1060)

https://doi.org/10.36660/abc.20200342 591 downloads

13.

Warthin-like and classic papillary thyroid cancer have similar clinical presentation and prognosis
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Olmos, Roberto

; Muñoz, Francisco

; Donoso, Francisca

; López, Jorge

; Bruera, María José

; Ruiz-Esquide, Magdalena

; Mosso, Lorena

; Lustig, Nicole

; Solar, Antonieta

; Droppelmann, Nicolás

; Montero, Pablo H.

; González, Hernán E.

; Domínguez, José Miguel

Archives of Endocrinology and Metabolism

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Out 2020, Volume 64 Nº 5 Páginas 542 - 547

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective Warthin-like papillary thyroid cancer (WL-PTC) is an uncommon variant of PTC, usually associated with lymphocytic thyroiditis. Scarce evidence suggests that WL-PTC has similar clinical presentation to classic PTC (C-PTC), with no studies comparing risks of recurrence and response to treatment between both variants. Our objective was to describe the clinical presentation and prognosis of WL-PTC and compare it to C-PTC. Subjects and methods Retrospective analysis of a prospective cohort, including 370 (96%) patients with C-PTC and 17 (4%) with WL-PTC, consecutively treated with total thyroidectomy with or without RAI, followed for at least 6 months. We compared clinical presentation, risk of mortality and recurrence, as well as response to treatment between both variants. Results Of the total cohort: 317 (82%) female, 38 ± 13.5 years, median follow-up 4 years (0.5-28.5); most of them stage I and low/intermediate risk of recurrence. We found no differences regarding clinical-pathological data and risk of recurrence. WL-PTC was associated with a higher rate of anti-thyroglobulin antibodies (TgAb) (65% vs. 36%, p = 0.016) and lymphocytic thyroiditis (59% vs. 34%, p = 0.03). The rates of biochemical and structural incomplete responses were similar in both variants. WL-PTC had a lower rate of excellent response (23% vs. 54%, p = 0.01), which became non-significant when performing analysis by TgAb presence (50% vs. 67%, p = NS). Conclusions WL-CPT and C-CPT have similar clinical presentation and rate of recurrence. The lower rate of excellent response to treatment in WL-PTC is due to a higher frequency of TgAb. WL-PCT should not be considered an aggressive variant of PTC.

https://doi.org/10.20945/2359-3997000000270 436 downloads

14.

“Tiger stripes” sign in acute coronary syndrome
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Cervantes-Nieto, Jorge A.

; Rivera-Silverio, Daniel A.

; Gopar-Nieto, Rodrigo

; Azar-Manzur, Francisco

; Ruiz-Esparza, Maria E.

; Raymundo-Martínez, Grecia I.M.

Archivos de cardiología de México

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Set 2020, Volume 90 Nº 3 Páginas 349 - 350

Resumo: En | Texto: En | PDF: En

Abstract The incidence of mitral regurgitation in acute myocardial syndromes is variable. Echocardiographic evaluation is fundamental in making a proper diagnosis of mechanical complications and to offer timely treatment. We present a case of a 64-year-old male who was admitted to the ER in acute pulmonary edema. The electrocardiogram showed negative ST-segment deviation from V4-V6, positive ST-segment deviation in aVR. Multivessel disease with severe mitral regurgitation was seen in catheterization. A transthoracic echocardiogram revealed important mitral regurgitation showing the “tiger stripes” sign, seen in the presence of intracardial oscillating structures, in this case, suspected papillary muscle rupture. Echocardiographic evaluation is necessary in every case of myocardial infarction who present with new-onset mitral regurgitation. Treatment is complex and must be determined with an interdisciplinary group.

https://doi.org/10.24875/acm.20000065 394 downloads

15.

Design, manufacture and initial tests of a drug-eluting coronary stent
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Abundes-Velasco, Arturo

; Padilla-Ibarra, Jorge

; Jiménez-Rodríguez, Gian M.

; Farjat-Pasos, Julio I.

; Arias-Sánchez, Eduardo A.

; Damas-de los Santos, Félix

; Martínez-Ríos, Marco A.

; Molina-Méndez, Francisco J.

; Sánchez-Pérez, Tomás E.

; Arai-Ito, Marco M.

; Aceves-Díaz González, Sebastián

; Rodríguez-Parra, David A.

; Aranda-Fraustro, Alberto

; Masso-Rojas, Felipe A.

; Galaz-Méndez, Ramsés

; Peña-Duque, Marco A.

Gaceta médica de México

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Ago 2020, Volume 156 Nº 4 Páginas 276 - 282

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Introduction: A drug-eluting coronary stent is being developed at the National Institute of Cardiology of Mexico for the treatment of ischemic heart disease. Objective: To establish the best animal model for the tests, to show the advances in the drug-eluting stent prototype, to assess two drugs’ antiproliferative activity and histological results. Method: Smooth muscle cell culture tests were performed in order to assess sirolimus and paclitaxel antiproliferative properties. The drugs were encapsulated inside the polymeric matrix of the stents. Rabbits and pigs were used as animal models. Results: Sirolimus and paclitaxel showed an inhibitory effect, which was higher for the latter. Infrared spectroscopy and light and optical microscopy showed that the drug/polymer layer properly adhered to the stent. At a four-week follow-up, both animal models showed satisfactory clinical evolution and adequate histological response, although the porcine model was shown to be more suitable for future protocols. Conclusions: Preliminary tests of the drug-eluting stent provided bases for the development of a study protocol with an adequate number of pigs and with clinical angiographic and histopathological three-month follow-up.

Resumen Introducción: En el Instituto Nacional de Cardiología de México se desarrolla una endoprótesis (stent) coronaria liberadora de fármacos para el tratamiento de la cardiopatía isquémica. Objetivo: Establecer el mejor modelo animal para las pruebas, mostrar los avances en el prototipo del stent liberador de fármacos, evaluar la actividad antiproliferativa de dos fármacos y los resultados histológicos. Método: Se realizaron cultivos de células de músculo liso para evaluar las propiedades antiproliferativas de sirolimus y paclitaxel. Los fármacos fueron encapsulados en el interior de la matriz polimérica de los stents. Se emplearon conejos y cerdos como modelos animales. Resultados: Sirolimus y paclitaxel mostraron efecto inhibitorio, mayor en el segundo. La espectroscopia infrarroja y la microscopia óptica y electrónica mostraron que la capa del polímero con el fármaco se adhería adecuadamente al stent. A las cuatro semanas de seguimiento, ambos modelos animales mostraron evolución clínica satisfactoria y adecuada respuesta histológica, si bien el modelo porcino resultó más conveniente para protocolos futuros. Conclusiones: Las pruebas preliminares del stent liberador de fármaco brindó bases para desarrollar el protocolo con un número adecuado en cerdos y con seguimiento clínico angiográfico e histopatológico a tres meses.

https://doi.org/10.24875/gmm.m20000418 141 downloads

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