BACKGROUND: Patterns of SARS-CoV-2 spread have varied by geolocation, with differences in seroprevalence between urban and rural areas, and between waves. Household spread of SARS-CoV-2 is a known source of new COVID-19 infections, with rural areas in sub-Saharan Africa being more prone than urban areas to COVID-19 transmission because of limited access to water in some areas, delayed health-seeking behaviour and poor access to care OBJECTIVES: To explore SARS-CoV-2 infection incidence and transmission in rural households in South Africa (SA METHODS: We conducted a prospective household cluster investigation between 13 April and 21 July 2021 in the Matjhabeng subdistrict, a rural area in Free State Province, SA. Adults with SARS-CoV-2 confirmed by polymerase chain reaction (PCR) tests (index cases, ICs) and their household contacts (HCs) were enrolled. Household visits conducted at enrolment and on days 7, 14 and 28 included interviewer-administered questionnaires and respiratory and blood sample collection for SARS-CoV-2 PCR and SARS-CoV-2 immunoglobulin G serological testing, respectively. Co-primary cases were HCs with a positive SARS-CoV-2 PCR test at enrolment. The incidence rate (IR), using the Poisson distribution, was HCs with a new positive PCR and/or serological test per 1 000 person-days. Associations between outcomes and HC characteristics were adjusted for intra-cluster correlation using robust standard errors. The secondary infection rate (SIR) was the proportion of new COVID-19 infections among susceptible HCs RESULTS: Among 23 ICs and 83 HCs enrolled, 10 SARS-CoV-2 incident cases were identified, giving an IR of 5.8 per 1 000 person-days (95% confidence interval (CI) 3.14 - 11.95). Households with a co-primary case had higher IRs than households without a co-primary case (crude IR 14.16 v. 1.75, respectively; p=0.054). HIV infection, obesity and the presence of chronic conditions did not materially alter the crude IR. The SIR was 15.9% (95% CI 7.90 - 29.32). Households with a lower household density (fewer household members per bedroom) had a higher IR (IR 9.58; 95% CI 4.67 - 21.71) than households with a higher density (IR 3.06; 95% CI 1.00 - 12.35 CONCLUSION: We found a high SARS-CoV-2 infection rate among HCs in a rural setting, with 48% of households having a co-primary case at the time of enrolment. Households with co-primary cases were associated with a higher seroprevalence and incidence of SARS-CoV-2. Sociodemographic and health characteristics were not associated with SARS-CoV-2 transmission in this study, and we did not identify any transmission risks inherent to a rural setting

ABSTRACT Efficient products can be developed for the ornamental plant sector using agro-industrial waste. This study evaluated the agronomic performance and ornamental quality of calendula plants (Calendula officinalis) cultivated in substrates formulated with solarized aerobic sewage sludge (SASS), rice husk ash (RHA), and sugarcane bagasse (SB). Five additive rates were used: S2: 33.33% SASS + 33.33% RHA + 33.33% SB; S3: 16.65% SASS + 41.67% RHA + 41.67% SB; S4: 12.48% SASS + 43.76% RHA + 43.76 % SB; S5: 8.32% SASS + 45.84% RHA + 45.84 % SB; S6: 4.16% SASS + 41.07% RHA + 54.76% SB; and S1: commercial substrate (reference). Raw materials and substrate formulations were characterized and agronomic and ornamental aspects were evaluated in calendula plants cropped in all substrates. The lowest agronomic performance was observed in S6 (lowest SASS rate), while the highest occurred in S3 compared to the other treatments. Regarding the ornamental potential, S3 and S4 and the commercial substrate (S1) were classified as excellent. This study highlights the successful use of organic raw materials (SASS and agro-industrial waste) to compose substrates for calendula production in pots, with the recommended proportions ranging from 12.48 to 16.65% of SASS combined with RHA and SB.

JUSTIFICATIVA E OBJETIVOS: A proficiência em bloqueios guiados por ultrassom exige quatro habilidades: reconhecimento da sonoanatomia, capacidade de geração de imagens, alinhamento da agulha ao feixe ultrassonográfico e reconhecimento da dispersão do anestésico local. O objetivo deste estudo foi construir e avaliar curvas de aprendizado da geração de imagens e identificação ultrassonográfica das estruturas neurovasculares axilares. MÉTODO: Sete médicos em especialização em Anestesiologia receberam noções teóricas e práticas sobre princípios básicos da ultrassonografia e sonoanatomia axilar visando identificar ramos terminais do plexo braquial e vasos axilares. Cada um dos ME realizou seis exames. Foram avaliados a acurácia e o tempo transcorrido para identificação das estruturas. Em cada exame foram calculadas taxas de sucesso. Regressão linear simples avaliou o tempo para identificação de cada estrutura em relação ao número do exame. RESULTADOS: Os vasos axilares foram identificados em 100% dos exames. O nervo mediano foi identificado em 83% dos exames entre o primeiro e quinto. O nervo radial foi identificado em 100% dos exames. O nervo ulnar foi encontrado em 67% dos casos no primeiro exame e em 83% dos casos do segundo ao quinto procedimento. O nervo músculo-cutâneo foi localizado em 50% dos casos no primeiro exame, em 83% no quarto e no quinto exames. Todas as estruturas foram corretamente detectadas no sexto exame. O tempo médio para identificação das estruturas diminuiu significativamente entre o primeiro e sexto exames (r = - 0,37). CONCLUSÕES: A memorização sonoanatômica axilar e a aquisição de habilidade manual de exame ultrassonográfico foram obrigatórias para progressão do aprendizado e taxas de sucesso crescentes se associaram com redução significativa do tempo para identificação das estruturas.

BACKGROUND AND OBJECTIVES: Proficiency in ultrasound-guided blocks demands four skills: recognition of the ultrasound anatomy, capacity to generate images, aligning the needle with the ultrasound beam, and recognizing the dispersion of the local anesthetic. The objective of this study was to construct and evaluate learning curves for image generation and ultrasound identification of the neurovascular structures in the axilla. METHODS: Seven Anesthesiology residents received theoretical and practical notions on the basic principles of ultrasound and the ultrasound anatomy of the axillary region with the objective to identify the terminal branches of the brachial plexus and axillary vessels. Each resident performed six exams. The accuracy and the time to identify the structures were evaluated. The success rate of each exam was calculated. Simple linear regression evaluated the time necessary to identify each structure in relation to the number of the exam. RESULTS: The axillary vessels were identified in 100% of the exams. The median nerve was identified in 83% of the cases from the first to the fifth exams. The radial nerve was identified in 100% of the exams. The ulnar nerve was identified in 67% of the cases in the first exam, and in 83% of the cases from the second to the fifth exams. The musculocutaneous nerve was identified in 50% of the cases in the first exam and in 83% of the cases in the fourth and fifth exams. All structures were identified correctly on the sixth exam. The mean time for the correct identification of the structures decreased considerably from the first to the sixth exam (r = - 0.37). CONCLUSIONS: Learning progression required the memorization of the ultrasound anatomy of the axillary region and acquisition of manual ability, and increasing success rates were associated with a significant reduction in the time to identify the structures.

JUSTIFICATIVA Y OBJETIVOS: El desempeño en bloqueos guiados por ultrasonido exige cuatro habilidades: reconocimiento de la Sonoanatomía, capacidad de generación de imágenes, alineación de la aguja al haz ultrasonográfico y reconocimiento de la dispersión del anestésico local. El objetivo de este estudio fue construir y evaluar curvas de aprendizaje de la generación de imágenes e identificación ultrasonográfica de las estructuras neurovasculares axilares. MÉTODO: Siete médicos en especialización en Anestesiología recibieron nociones teóricas y prácticas sobre principios básicos de la ultrasonografía y sonoanatomía axilar, para identificar ramas terminales del plexo braquial y vasos axilares. Cada ME realizó seis exámenes. Fueron evaluados la exactitud y el tiempo transcurrido para la identificación de las estructuras. Se calcularon las tasas de éxito en cada examen. La regresión lineal simple evaluó el tiempo para la identificación de cada estructura con relación al número del examen. RESULTADOS: Los vasos axilares fueron identificados en 100% de los exámenes. El nervio mediano fue identificado en un 83% de los exámenes entre el primero y el quinto. El nervio radial fue identificado en 100% de los exámenes. El nervio cubital fue identificado en un 67% de los casos en el primer examen y en un 83% de los casos del segundo al quinto procedimiento. El nervio musculocutáneo fue identificado en un 50% de los casos en el primer examen, en un 83% en el cuarto y en el quinto exámenes. Todas las estructuras fueron correctamente identificadas en el sexto examen. El tiempo promedio para la identificación de las estructuras se redujo significativamente entre el primer y el sexto examen (r = - 0,37). CONCLUSIONES: La memorización sonoanatómica axilar y la adquisición de habilidad manual de examen ultrasonográfico, fueron obligatorias para la progresión del aprendizaje y para que las tasas de éxito crecientes se asociasen con una reducción significativa del tiempo para la identificación de las estructuras.

PURPOSE: Catheter-based medical devices are an important component of the urologic armamentarium. To our knowledge, there is no population-based data regarding normal male urethral length. We evaluated the length of the urethra in men with normal genitourinary anatomy undergoing either Foley catheter removal or standard cystoscopy. MATERIALS AND METHODS: Male urethral length was obtained in 109 men. After study permission was obtained, the subject's penis was placed on a gentle stretch and the catheter was marked at the tip of the penis. The catheter was then removed and the distance from the mark to the beginning of the re-inflated balloon was measured. Alternatively, urethral length was measured at the time of cystoscopy, on removal of the cystoscope. Data on age, weight, and height was obtained in patients when possible. RESULTS: The mean urethral length was 22.3 cm with a standard deviation of 2.4 cm. Urethral length varied between 15 cm and 29 cm. No statistically significant correlation was found between urethral length and height, weight, body mass index (BMI), or age. CONCLUSIONS: Literature documenting the length of the normal male adult urethra is scarce. Our data adds to basic anatomic information of the male urethra and may be used to optimize genitourinary device design.

Amidarone (AMD) is an antiarrhytmic drug with side effects on the nervous system. Cerebellum is seldom involved. We describe the case of a 56 years old male patient with a history of 4 month of cerebellar involvement characterized by gait unstadiness, ataxia, nistagmus and vertigo. He was on treatment with AMD because of ventricular arrythmia. The cerebellar syndrom progressively disappeared after drug whitdrawal and he was symptoms-free 4 months later. Similar symptoms appeared after another one month of automedication with the same drug. Structural lesions, metabolic, nutritional deficiencies or toxics were excluded. Mechanisms of cerebellar toxicity of AMD are yet unknown. The knowledge of the toxic effects of this drug, widely used in our country, would allow its early recognition.

La amiodarona (AMD) es una droga antiarritmica cuyos efectos adversos pueden comprometer el sistema nervioso central y periferico. La aparición de un síndrome cerebeloso es infrecuente. Se presenta un paciente masculino de 56 anos de edad que desarolla un síndrome pancerebeloso de 4 meses de evolución, que revierte luego de la suspension de la AMD. El cuadro reaparece meses mas tarde luego de un periodo de automedicacion con la droga. Los mecanismos tóxicos por los cuales la AMD afecta al cerebelo permanecen inciertos. Esta droga de amplia difusión en nuestro medio, como otros antiarritmicos, posee efectos sobre el sistema nervioso que deben ser tenidos en cuenta a fin de poder detectarlos precozmente.