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ABSTRACT Objective: The optimal target for blood glucose concentration in critically ill patients is unclear. We will perform a systematic review and meta-analysis with aggregated and individual patient data from randomized controlled trials, comparing intensive glucose control with liberal glucose control in critically ill adults. Data sources: MEDLINE®, Embase, the Cochrane Central Register of Clinical Trials, and clinical trials registries (World Health Organization, clinical trials.gov). The authors of eligible trials will be invited to provide individual patient data. Published trial-level data from eligible trials that are not at high risk of bias will be included in an aggregated data meta-analysis if individual patient data are not available. Methods: Inclusion criteria: randomized controlled trials that recruited adult patients, targeting a blood glucose of ≤ 120mg/dL (≤ 6.6mmol/L) compared to a higher blood glucose concentration target using intravenous insulin in both groups. Excluded studies: those with an upper limit blood glucose target in the intervention group of > 120mg/dL (> 6.6mmol/L), or where intensive glucose control was only performed in the intraoperative period, and those where loss to follow-up exceeded 10% by hospital discharge. Primary endpoint: In-hospital mortality during index hospital admission. Secondary endpoints: mortality and survival at other timepoints, duration of invasive mechanical ventilation, vasoactive agents, and renal replacement therapy. A random effect Bayesian meta-analysis and hierarchical Bayesian models for individual patient data will be used. Discussion: This systematic review with aggregate and individual patient data will address the clinical question, ‘what is the best blood glucose target for critically ill patients overall?’ Protocol version 0.4 - 06/26/2023 PROSPERO registration: CRD42021278869

RESUMO Objetivo: Não está claro qual é a meta ideal de concentração de glicose no sangue em pacientes em estado grave. Realizaremos uma revisão sistemática e uma metanálise com dados agregados e de pacientes individuais de estudos controlados e randomizados, comparando o controle intensivo da glicose com o controle liberal da glicose em adultos em estado grave. Fontes de dados: MEDLINE®, Embase, Cochrane Central Register of Clinical Trials e registros de ensaios clínicos (Organização Mundial da Saúde, clinical trials.gov). Os autores dos estudos qualificados serão convidados a fornecer dados individuais de pacientes. Os dados publicados em nível de ensaio qualificado que não apresentem alto risco de viés serão incluídos em uma metanálise de dados agregados se os dados individuais de pacientes não estiverem disponíveis. Métodos: Critérios de inclusão: ensaios clínicos controlados e randomizados que recrutaram pacientes adultos, com meta de glicemia ≤ 120mg/dL (≤ 6,6mmol/L) comparada a uma meta de concentração de glicemia mais alta com insulina intravenosa em ambos os grupos. Estudos excluídos: aqueles com meta de glicemia no limite superior no grupo de intervenção > 120mg/dL (> 6,6mmol/L), ou em que o controle intensivo de glicose foi realizado apenas no período intraoperatório, e aqueles em que a perda de seguimento excedeu 10% até a alta hospitalar. Desfecho primário: Mortalidade intra-hospitalar durante a admissão hospitalar. Desfechos secundários: Mortalidade e sobrevida em outros momentos, duração da ventilação mecânica invasiva, agentes vasoativos e terapia de substituição renal. Utilizaremos metanálise bayesiana de efeito randômico e modelos bayesianos hierárquicos para dados individuais de pacientes. Discussão: Essa revisão sistemática com dados agregados e de pacientes individuais abordará a questão clínica: Qual é a melhor meta de glicose no sangue de pacientes graves em geral? Protocolo versão 0.4 - 26/06/2023 Registro PROSPERO: CRD42021278869

https://doi.org/10.5935/2965-2774.20230162-en

A Study on the Ancient theater of official house in The Taihang mountain area of North Henan Province in China
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Peng, Hengli

; Li, Hanwen

Trans/Form/Ação

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2023, Volume 46 Nº spe Páginas 153 - 176

Resumo: It En | Texto: It En | PDF: It | PDF: En

Riassunto: L’antico teatro della Casa Ufficiale è un antico teatro esistente nell’area Montuosa del Taihang nella Provincia dell’Henan Settentrionale, il quale nacque nel periodo centrale della Dinastia Qing. L’aspetto dell’antico teatro della Casa Ufficiale è legato all’ambiente naturale locale, alla cultura popolare e alla produttività agricola. Ci sono otto antiche fasi della casa ufficiale nell’area Montuosa del Taihang nella Provincia dell’Henan Settentrionale, che forniscono prove fisiche per lo studio del dramma teatrale popolare nell’area Montuosa del Taihang durante la dinastia Qing. Le iscrizioni sulle stele e sul palcoscenico dell’opera tradizionale cinese riflettono alcune caratteristiche del dramma teatrale rappresentato dai funzionari fin dalla dinastia Qing in Cina. I tipi di opere eseguite sono opere locali, le quali rappresentano dei preziosi materiali per lo studio storico. In una certa misura, è possibile ricostruire il percorso lo sviluppo regionale della società, della cultura e della vita quotidiana locale. Riassunto Lantico L nellarea nell area dellHenan dell Henan Settentrionale Laspetto aspetto dellantico allambiente all ambiente locale agricola dellopera opera Cina locali storico misura società

Abstract: As a particular type of ancient Chinese theater, talented theater of official house was mainly found in the Taihang Mountain area, in North Henan Province, which was formed in the middle of the Qing Dynasty. The appearance of it is related to the local natural environment, folk culture and agricultural productivity. Through field investigation, it is found that there are eight existing theaters in the Taihang Mountain area of North Henan Province; among which three ones are newly discovered that have not been documented by the academic circle before, as well as several traditional Chinese opera steles and wall inscriptions. This is the first time the academic circle discloses relevant data and information. These provide physical evidence the performance of the village opera in the Taihang Mountain area of the Qing Dynasty, in China. Especially the inscriptions on the steles and the stage wall can reflect some features of the local opera performance since the Qing Dynasty, such as the type, time, troupe, and so on. To some extent, the richness of these ancient theaters of official house, with the architectural styles of ancient Chinese opera, has a significant value related to historical material and cultural relics. The first-hand data obtained in the investigation will also provide the latest research materials on ancient Chinese opera and theater architecture. Abstract Province Dynasty environment productivity before information China troupe extent relics firsthand hand architecture

https://doi.org/10.1590/0101-3173.2023.v46esp.p151

Path of exploring opportunities in a migrant workers returning- to home entrepreneurial ecosystem
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Yao, Jun

; Li, Huajing

; Xu, Xiaoyan

; Qiu, Sining

; Shang, Di

Ciência Rural

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2022, Volume 52 Nº 11 elocation e20210493

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Com o rápido desenvolvimento da industrialização e da urbanização, o empreendedorismo voltando para cidade natal tem recebido cada vez mais atenção dos círculos sociais e acadêmicos. Nesse texto, adotando um método de análise estatística descritiva, analisamos a situação atual e o processo pelo qual os empreendedores do ecossistema de empreendedorismo voltando para cidade natal participam do desenvolvimento de oportunidades empreendedoras nas duas dimensões: aquisição de recursos e apoio institucional. E adotando o método de análise de rede social, exploramos o mecanismo de desenvolvimento de oportunidades de cada sujeito do ecossistema de empreendedorismo de retorno de cidade natal. Os resultados mostram que durante o desenvolvimento das oportunidades de empreendedorismo de retorno de cidade natal, todos os sujeitos do ecossistema de empreendedorismo de retorno de cidade natal participaram com seus próprios recursos e capacidades e promoveram conjuntamente o desenvolvimento de oportunidades. Durante o desenvolvimento dessas oportunidades, cada sujeito do ecossistema do empreendedorismo de retorno de cidade natal participou de diferentes formas e com diferentes ênfases. Este texto ajuda a enriquecer a pesquisa de integração da teoria do empreendedorismo de retorno de cidade natal e da teoria do ecossistema de inovação, e além disso fornece uma referência para realizar a revitalização rural e promover o desenvolvimento econômico regional.

ABSTRACT: With the rapid development of industrialization and urbanization, returning-home entrepreneurship has received increasing attention from social and academic circles. This paper adopted the method of descriptive statistics to analyze the current situation, and the process by which entrepreneurs in the returning-home entrepreneurship ecosystem participate in the development of entrepreneurial opportunities from two dimensions: resource acquisition and institutional support. This research adopted the method of social network analysis to explore the mechanism of opportunity development of each subject of the returning-home entrepreneurship ecosystem. The results showed that during the opportunity development of returning-home entrepreneurship, all the subjects in the returning-home entrepreneurship ecosystem participated with their own resources and capabilities and jointly promoted the development of opportunities. During the development of these opportunities, each subject in the returning-home entrepreneurship ecosystem participated in different ways and with different emphases. This paper enriched the integration research of returning-home entrepreneurship theory and innovation ecosystem theory, and provided a reference for realizing rural revitalization and promoting regional economic development.

https://doi.org/10.1590/0103-8478cr20210493

Immunomodulatory effects of Blaps rynchopetera extract
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Meng, Di

; Yang, Yinhe

; Li, Longxing

; Qian, Xiaoli

; Wang, Qi

; Xu, Jinglei

; Zhao, Hairong

; Liu, Heng

; Xiao, Huai

; Ding, Zhongtao

Acta Cirúrgica Brasileira

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2022, Volume 37 Nº 2 elocation e370205

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire. Methods: Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised mice models. Results: In vitro, total extract, as well as chloroform, ethyl acetate, n-butanol and water fractions could individually enhance the phagocytic ability of mouse peritoneal macrophages; in addition, chloroform and ethyl acetate fractions had an increasing tendency when combined stimulation with lipopolysaccharide (LPS). In vivo, ethyl acetate fraction (EAF) could enhance the immune organ index, increase the serum hemolysin level and peripheral blood immune cells of immunocompromised mice, while for normal mice, the effect was inconspicuous. Conclusions: Blaps rynchopetera extracts had noteworthy immunomodulatory effect, especially for individuals with immune disorders.

https://doi.org/10.1590/acb370205

Effects of melatonin on testicular function in adult male mice under different photoperiods
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Jiang, Dan-li

; Xu, Yang-long

; Pan, Jian-qiu

; Fan, Di

; Shen, Xu

; Li, Wan-yan

; Ou-Yang, Hong-jia

; Xu, Dan-ning

; Tian, Yun-bo

; Huang, Yun-mao

Animal Reproduction

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2022, Volume 19 Nº 3 elocation e20220038

Resumo: En | Texto: En | PDF: En

Abstract Photoperiod is an important environmental factor affecting animal physiological function. Melatonin is an endogenous hormone that plays an important role in circadian and seasonal (or cyclical) rhythms and seasonal reproduction in mammals. To investigate the effects of melatonin on the reproductive performance of adult male mice under different photoperiods, sixty mice were randomly allotted to six groups: control (Light Dark, 12 L:12 D), control plus melatonin (MLD, 12 L:12 D), 24-hour continuous light (LL, 24 L:0 D), 24-hour continuous light plus melatonin (MLL 24 L:0 D), constant darkness (DD, 0 L:24 D), and constant darkness plus melatonin (MDD, 0 L:24 D). Normal saline (100 μL) was injected into the LD, LL, and DD groups at noon each day; the MLD, MLL, and MDD groups were injected with melatonin (1 mg/mL; 2 mg/kg·body weigh). After 24 hours of prolonged light exposure, testis morphology decreased, convoluted seminiferous tubules became sparse, the diameter of convoluted seminiferous tubules decreased, and the level of sex hormones decreased. After the administration of exogenous melatonin, testicular morphology and sex hormone levels decreased in the MLD group under normal light conditions. In the MLL group, the testicular tissue morphology returned to normal, the diameter of convoluted tubules increased, the hormone levels of LH (Luteinizing hormone) and MTL (melatonin) significantly increased (P<0.05), and th0e gene expressions of LHβ and Mtnr1A (Melatonin receptors 1A) increased. There was almost no difference in the MDD group under continuous darkness. In conclusion, melatonin can damage the reproductive performance of male mice under normal light conditions, while exogenous melatonin can alleviate and protect the testicular injury of male mice under continuous light conditions.

https://doi.org/10.1590/1984-3143-ar2022-0038

Trehalose addition to a Tris-fructose egg yolk extender on quality of ram sperm preserved at 0 °C
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Zhao, Jianqing

; Xiao, Guoliang

; Zhu, Wenliang

; Fang, Di

; Li, Na

; Han, Chunmei

; Gao, Qinghua

Revista Brasileira de Zootecnia

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2020, Volume 49 elocation e20200061

Resumo: En | Texto: En | PDF: En

ABSTRACT The present study investigated the effects of various concentrations of trehalose in Tris-fructose egg yolk diluent on ram semen preservation at 0 ℃. Semen was collected by artificial vagina ejaculation from six rams of proven fertility. High-quality ejaculates were diluted with 0 (control), 5, 10, 15, and 20 mM trehalose of Tris-fructose egg yolk extender and control (tris-fructose egg yolk extender without trehalose), respectively. Then, the ejaculates were diluted to a concentration of 5×108 sperm/mL, cooled to 0 ℃ for 90 min, and maintained at that temperature for twelve days. The diluted semen samples were examined, and their sperm progressive motility, membrane functionality, and acrosome integrity recorded at 0, 24, 72, 144, 216, and 288 h. Two hundred ninety-six ewes were transcervically inseminated with the 216-h control (without trehalose) or the optimal trehalose concentration group semen, and the pregnancy and lambing rates were measured. No significant differences were established in the sperm progressive motility and membrane functionality among the control and 5, 10, 15, and 20 mM groups. The sperm samples of trehalose addition groups had no significant difference in the acrosome integrity of sperm, but they were, nonetheless, significantly higher than those in the control. No significant difference was detected in the lambing and pregnancy rates between the 5 mM and control groups. These results suggest that ram sperm is capable of fertilization after cooling and preservation at 0 ℃ by the use of 5 mM trehalose for Tris-fructose egg yolk diluent. Under these conditions, ram sperm can be more effectively preserved than under other four concentrations of diluents.

https://doi.org/10.37496/rbz4920200061 161 downloads

Microstructure and Properties of Duplex Ni-P-TiO2/Ni-P Nanocomposite Coatings
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Zhang, Weihui

; Cao, Di

; Qiao, Yanxin

; He, Zhen

; Wang, Yuxin

; Li, Xiang

; Gao, Wei

Materials Research

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2019, Volume 22 elocation e20180748

Resumo: En | Texto: En | PDF: En

Duplex Ni-P-TiO2/Ni-P coatings were electrodeposited onto brass substrates. High phosphorus Ni-P coatings were plated as the inner layer to improve the corrosion resistance, while low phosphorus sol-enhanced Ni-P-TiO2 coatings were deposited on the top to strengthen the mechanical property. The microstructure, morphology, mechanical property and corrosion resistance of coatings were investigated systematically. The results show that duplex coatings exhibit both excellent mechanical property and good corrosion resistance. The hardness was further improved from ~545 HV50 of duplex Ni-P/Ni-P coating to ~622 HV50 of duplex Ni-P-12.5mL/L TiO2/Ni-P coating, while the hardness of single Ni-P coating was only ~387 HV50. The corrosion resistance of duplex coatings improved significantly by adding a suitable amount of TiO2 sol. Duplex Ni-P-12.5mL/L TiO2/Ni-P coating presented the highest corrosion resistance. However, adding excessive quantities of sol (more than 12.5mL/L) caused nanoparticle agglomeration and created a porous structure in the outer layer, deteriorating the properties of coatings.

https://doi.org/10.1590/1980-5373-mr-2018-0748 992 downloads

Macro-Micromechanical Properties of Sandy Pebble Soil of Different Coarse-Grained Content
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Junfu Lu, Di Li

; Xiaoqiang, Xue

; Shenlin, Ling

Earth Sciences Research Journal

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Mar 2018, Volume 22 Nº 1 Páginas 65 - 71

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La capa de arena guijosa es un manto típico de partículas inestables que consisten principalmente de arena y guijarros. Sin embargo, el efecto del contenido de grano grueso en la estabilidad de la capa no es claro. El área de investigación en este estudio es la ciudad de Chengdu, provincia de Sichuan, en China. Allí se tomaron muestras de diferente clasificación granulométrica para analizar las propiedades macro y mesomecánicas del suelo de arena guijosa a través del método combinado de la prueba triaxial a gran escala en laboratorio para suelos de grano grueso con la prueba triaxial numérica de elementos discretos. Los resultados de la investigación muestran que la curva del ensayo de tracción en suelos de arena guijosa presenta un aplacamiento en la presión con el incremento del contenido de grano grueso. Cuando la presión de confinamiento fue la misma, el pico de esfuerzo se incrementó y la presión empezó a caer gradualmente cuando se alcanzó el pico con el incremento del contenido de grano grueso. Esto revela la relación funcional entre el contenido de grano grueso y los indicadores mecánicos para suelos de arena guijosa como el ángulo de fricción interna y la cohesión; estos factores se incrementaron con el aumento del material de grano grueso. Esto sugiere los microparámetros de particulas de elementos discretos en este tipo de suelos, que incluyen el modulo de contacto, el coeficiente de fricción, la proporción de rigidez de partículas y la fuerza del vínculo de contacto. Los resultados de la investigación proporcionan el apoyo teórico para el diseño y construcción de nuevos proyectos sobre la capa arenosa y guijarrosa.

ABSTRACT Sandy pebble stratum is a typical discrete particle unstable stratum, mainly consisting of sand and pebble. However, the effect of coarse-grained content on the stability of stratum is not clear. In this paper, taking the sandy pebble soil of different coarse-grained content in Chengdu City, Sichuan Province, China as the research object, a research on macro-mesomechanical properties of sandy pebble soil of different coarse-grained content was carried out using the method combining the indoor large-scale triaxial test of coarse-grained soil with the discrete element numerical triaxial test. The research results showed that the stress-strain curve of sandy pebble soil exhibited strain softening with the increase of coarse-grained content; when the confining pressure was the same, the stress peak increased and the strain when the peak was reached decreased gradually with the increase of coarse-grained content. It revealed the functional relationship between coarse-grained content and mechanical indexes of sandy pebble soil such as internal friction angle and cohesion, the internal friction angle and cohesion of sandy pebble soil linearly increased with the rise of coarsegrained material; it proposed the particle discrete element micro parameters of sandy pebble soil of different coarsegrained content, including contact modulus, friction coefficient, particle stiffness ratio, contact bond strength. The research results provided the theoretical support for the fine design and construction of sandy pebble stratum project.

https://doi.org/10.15446/esrj.v22n1.66105 271 downloads

Tissue distribution and excretion of the five components of Portulaca oleracea L. extract in rat assessed by UHPLC
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Zhang, Wenjie

; Li, Di

; Leng, Aijing

; Ai, Junjun

; Du, Yang

; Meng, Yihan

; Gao, Yucong

; Ying, Xixiang

Brazilian Journal of Pharmaceutical Sciences

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Set 2015, Volume 51 Nº 3 Páginas 643 - 651

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O objetivo do presente estudo foi investigar a distribuição tecidual e excreção de cinco componentes de extrato Portulaca oleracea L. (POE) em ratos após administração oral. Um método analítico rápido, sensível e específico para quantificação de cinco componentes de POE (ácido cafeico (CA), ácidop-cumárico (p-CA), ácido ferúlico (FA), quercitrina (QUER) e hesperidina (HP)) por cromatografia líquida de ultra eficiência (UHPLC), empregando puerarina como padrão interno de referência. Os compostos foram quantificados em diferentes tecidos dos animais, sendo eles fígado, intestino, estômago, músculo, coração, pulmão, cérebro, rim e baço, urina e fezes. Os resultados mostraram que apenas p-CA e FA foram encontradas em todos os tecidos com baixas taxas cumulativas e CA apresentou níveis mais altos no intestino e estômago com a taxa cumulativa um pouco mais elevada na urina e nas fezes após 24 h. HP e QUER apresentaram baixas concentrações nos tecidos com baixas taxas cumulativas.

The aim of the present study was to investigate the tissue distribution and excretion of five components of Portulaca oleracea L. extract (POE) in rat following oral administration. A rapid, sensitive and specific ultra-high performance liquid chromatography (UHPLC) method with puerarin as the internal standard was used for the quantitative analysis of five components of POE, including caffeic acid (CA), p-coumaric acid (p-CA), ferulic acid (FA), quercitrin (QUER) and hesperidin (HP) in rat tissues including the liver, intestine, stomach, muscle, heart, lung, brain, kidney and spleen, urine and feces. The results show that onlyp-CA and FA were found in nearly all tissues with low cumulative ratios, and CA was higher in the intestine and stomach with a slightly higher cumulative ratio in the urine and feces after 24 h. HP and QUER were found at low levels in the tissues with low cumulative ratios.

https://doi.org/10.1590/S1984-82502015000300016 8679 downloads

10.

Functional disruption of human leukocyte antigen II in human embryonic stem cell
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Chen, Haide

; Li, Yang

; Lin, Xijuan

; Cui, Di

; Cui, Chun

; Li, Hui

; Xiao, Lei

Biological Research

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2015, Volume 48 Páginas 1 - 9

Resumo: En | Texto: En | PDF: En

BACKGROUND: Theoretically human embryonic stem cells (hESCs) have the capacity to self-renew and differentiate into all human cell types. Therefore, the greatest promise of hESCs-based therapy is to replace the damaged tissues of patients suffering from traumatic or degenerative diseases by the exact same type of cells derived from hESCs. Allo-graft immune rejection is one of the obstacles for hESCs-based clinical applications. Human leukocyte antigen (HLA) II leads to CD4+ T cells-mediated allograft rejection. Hence, we focus on optimizing hESCs for clinic application through gene modification RESULTS: Transcription activator-like effector nucleases (TALENs) were used to target MHC class II transactivator (CIITA) in hESCs efficiently. CIITA-/-hESCs did not show any difference in the differentiation potential and self-renewal capacity. Dendritic cells (DCs) derived from CIITA-/-hESCs expressed CD83 and CD86 but without the constitutive HLA II. Fibroblasts derived from CIITA-/-hESCs were powerless in IFN-γ inducible expression of HLA II CONCLUSION: We generated HLA II defected hESCs via deleting CIITA, a master regulator of constitutive and IFN-γ inducible expression of HLA II genes. CIITA-/-hESCs can differentiate into tissue cells with non-HLA II expression. It's promising that CIITA-/-hESCs-derived cells could be used in cell therapy (e.g., T cells and DCs) and escape the attack of receptors' CD4+ T cells, which are the main effector cells of cellular immunity in allograft

https://doi.org/10.1186/S40659-015-0051-6 1024 downloads

11.

Preemptive analgesia effects of Ketamine in patients undergoing surgery. A meta-analysis
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Yang, Liqiao

; Zhang, Jianwei

; Zhang, Zheng

; Zhang, Chengmi

; Zhao, Di

; Li, Jingjie

Acta Cirúrgica Brasileira

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Dez 2014, Volume 29 Nº 12 Páginas 819 - 825

Resumo: En | Texto: En | PDF: En

PURPOSE: To evaluate the preemptive analgesia effects of ketamine for postoperative pain. METHODS: PubMed, EMBASE and Cochrane Library were searched to identify randomized controlled trials (RCTs) involved in ketamine for preemptive analgesic up to March 2013. The relative risk (RR) or mean difference (MD) as well as the confounding 95% confidence interval (CI) were calculated by the Revman 5.0 software. RESULTS: A total of five studies including 266 patients were included in this meta-analysis. Overall, ketamine could reduce the postoperative morphine consumption and significantly prolong the time to first analgesic (p < 0.00001, MD = 0.91, 95% CI: 0.56 to 1.26). However, there was no significant difference in indicators of nausea and vomiting (p = 0.87, RR = 1.04, 95% CI: 0.67 to 1.60), surgical time (p = 0.41, MD = -2.13, 95% CI: -7.21 to 2.95) and anesthetic time (p = 0.53, MD = -1.54, 95% CI: -6.34 to -3.26) between ketamine and control group. CONCLUSIONS: Ketamine was able to accomplish some preemptive analgesic effects of reducing postoperative morphine consumption and prolonging the time to first analgesic. Meanwhile, ketamine was as safe as physiological saline in side effects of nausea and vomiting.

https://doi.org/10.1590/S0102-86502014001900009 4183 downloads

12.

The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine intracranial abscesses model
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Gong, Jian

; Li, Dongzhi

; Yan, Jun

; Liu, Yu

; Li, Di

; Dong, Jie

; Gao, Yaping

; Sun, Tao

; Yang, Guang

Brazilian Journal of Infectious Diseases

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Out 2014, Volume 18 Nº 5 Páginas 501 - 506

Resumo: En | Texto: En | PDF: En

Background:Intracranial abscesses are associated with high mortality. Staphylococcus aureus is one of the main pathogens that cause intracranial infection. Until now, there is no report to identify the key effectors of S. aureus during the intracranial infection.Methods:The murine intracranial abscesses model induced by S. aureuswas constructed. The vital sign and survival rate of mice were observed to evaluate the infection. Histological examination was used to diagnose the pathological alterations of mouse tissues. The sensitivity of S. aureus to whole blood was evaluated by whole-blood killing assay.Results:In murine intracranial abscesses model, it was shown that the mortality caused by the accessory gene regulator (agr) locus deficient strain was significant decreased compared with its parent strain. Moreover, we found that RNAIII, the effector of agr system, was essential for the intracranial infection caused by S. aureus. In the further investigation, it was shown that restoration the expression of α-toxin in agr deficient strain could partially recover the mortality in the murine intracranial abscesses model.Conclusion:Our data suggested that the agr system of S. aureus is an important virulence determinant in the induction and mortality of intracranial abscesses in mice.

https://doi.org/10.1016/j.bjid.2014.03.005 1650 downloads

13.

Rapid response to high cut-off haemodialysis and bortezomib therapy in a patient with acute renal failure and plasma cells dyscrasia
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Li-Cavoli, Gioacchino

; Bassiano, Francesco Di

; Tortorici, Calogera

; Bono, Luisa

; Ferrantelli, Angelo

; Giammarresi, Carlo

; Passantino, Rita

; Rotolo, Ugo

Nefrología (Madrid)

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2014, Volume 34 Nº 5 Páginas 688 - 688

Resumo: En | Texto: En | PDF: En

https://doi.org/10.3265/Nefrologia.pre2014.Jun.12108 141 downloads

14.

Solvent-free Synthesis of 5H-dibenzo[b,i]xanthene-tetraones and Aryl-14H-dibenzo[a,j]xanthenes Using Ferric Chloride Hexahydrate as Catalyst
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Liu, Di

; Zhou, Shixue

; Gao, Jun

; Li, Lin

; Xu, Dongmei

Journal of the Mexican Chemical Society

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Dez 2013, Volume 57 Nº 4 Páginas 345 - 348

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract A simple and convenient procedure for the synthesis of 5Hdibenzo[b,i]xanthene-tetraones and aryl-14H-dibenzo[a,j]xanthenes is described through the condensation of aldehydes with 2-naphthol or 2-hydroxy-1, 4-naphthoquinone under solvent-free conditions in the presence of ferric chloride hexahydrate. This method has the advantages of high yields, cleaner reaction, simple work-up and cost efficiency.

Resumen Se describe una metodología simple para la síntesis de 5Hdibenzo[b,i]xanteno-tetraonas y aril-14H-dibenzo[a,j]xantenos. Los xantenos son obtenidos por condensación de aldehídos con 2-naftol o 2-hidroxi-1,4-naftoquinona en presencia de cloruro férrico hexahidratado. Las reacciones se llevan a cabo en ausencia de disolvente, son limpias, de bajo costo y con alto rendimiento.

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15.

Genetic diversity of Toll-like receptor 5 among pig populations
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Yang, Xiuqin

; Li, Haitao

; Guan, Qingzhi

; Liu, Di

Genetics and Molecular Biology

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2013, Volume 36 Nº 1 Páginas 37 - 42

Resumo: En | Texto: En | PDF: En

The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene in 83 individuals from five pig breeds, these including Chinese local populations and Western commercial pig breeds. A total of 19 medium polymorphic SNPs (0.25 < PIC < 0.5) were identified, three of which were missense mutations that clustered within the extracellular domain of TLR5. One of the non-synonymous SNPs fell within a 228-amino acid region which has been shown to be important for flagellin recognition. Four SNPs were only found with high frequencies in Oriental pig breeds. The 19 SNPs were found in 30 haplotypes, one of which segregated at high frequency in all samples. Compared with Western pig breeds, Chinese local populations had higher genetic diversity and more haplotypes. Tajima's test showed no evidence for deviation from neutrality. The data provide useful information for future genetic marker characterization by means of disease association analysis and/or stimulating the mutation carrier with relevant ligands.

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