ABSTRACT Introduction: New-onset postoperative atrial fibrillation (POAF) is a common complication following coronary artery bypass grafting (CABG) surgery. Objective: To explore predictive factors and potential mechanisms of new-onset POAF in isolated off-pump CABG patients. Methods: Retrospective observational case-control study of 233 patients undergoing isolated off-pump CABG surgery between August 2018 and July 2020 at the Department of Thoracic and Cardiovascular Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School. Associations between predictor variables and new-onset POAF were identified. The main outcome was new-onset POAF after CABG surgery. Results: A total of 75 (32.19%) patients developed new-onset POAF after CABG surgery. The new-onset POAF patients had advanced age, higher baseline systolic blood pressure, more preoperative use of diuretic drug, more transfusion of blood products, atrial dilation and postoperative positive inotropic drug treatment. Nineteen variates entered the multivariable logistic regression model with a Hosmer-Lemeshow test score of 7.565 (P=0.477). Postoperative left atrial enlargement, postoperative drainage in the first 24 hours and total length of hospital stay were statistically significant, while postoperative right atrial enlargement (OR and 95% CI, 7.797 [0.200, 304.294], P=0.272) and left atrial enlargement (3.524 [1.141, 10.886], P=0.029) assessed by echocardiography had the largest OR value. Conclusion: Atrial enlargement is strongly associated with new-onset POAF in patients with isolated off-pump CABG, thus it highlights the advantage of echocardiography as a useful tool for predicting new-onset POAF. Careful monitoring and timely intervention should be considered for these patients.

Abstract Exogenous additives applied for cigar tobacco leaves fermentation played an important role in sensory quality of cigar. In this study, effects of additives including coffee and cocoa on the quality of cigar tobacco leaves were explored. The changes of sensory quality, conventional chemical components, nonvolatile organic acids, and aroma compositions in tobacco leaves were studied. Results showed that the richness, mellowness and matureness of aroma, as well as the fluentness and sweetness of smoke in cigar were improved with the introduction of coffee or cocoa. According to chemical composition analysis, fermentation with coffee or cocoa increased the contents of alkaloids and sugar in tobacco leaves, which endowed the tobacco a relatively good performance on the sweetness and aroma richness. Besides, the decrease of citric acid, as well as the increase of saturated fatty acid and aroma components were found with additives, which was beneficial to improve the mellowness and aroma richness of cigar. It was suggested that coffee and cocoa exhibited positive effects on the chemical composition, especially increased the contents of sugar, saturated fatty acids and aromatic components, thus improving the sensory quality of tobacco leaves.

Abstract Human posture estimation is the basis of many computer vision tasks, such as motion recognition, violence detection and behavior understanding. Therefore, it is of great significance to study the estimation algorithm of human motion posture (HMP). To address the problem of poor estimation effect of traditional HMP estimation algorithm, in this paper, an estimation algorithm for HMP using multi-labeling transfer learning is proposed. First, the original human motion image is labeled by using the multi-label transfer learning, the HMP features are extracted, and the original image classification is completed. Second, a regulator is constructed based on the classification results of the original image, and the regulator is used to adjust the estimation results of HMP based on a convolutional neural networks. Finally, the posture compensation function is used to compensate for the error part to realize the estimation of HMP. In the experiment, the Human3.6m data set and MPII data set were used as the basis for testing. The results show that the proposed algorithm has high correct recognition rate of HMP. The similarity between the posture estimation results, and the target image is 92%-97%. The accuracy of posture estimation is 98.1%. The proposed algorithm can be widely used in many fields, such as human-computer interaction, recognition authentication and intelligent monitoring.

Abstract This study presents the preparation of cinnamon essential oil Pickering emulsion, aiming to improve the physicochemical properties, water sol ubility, and emulsion stability of cinnamon essential oil. The oil-in-water Pickering emulsion was prepared by ultrasonic emulsification, in which SPICS (soybean protein isolate (SPI)-chitosan (CS) composite granule) was used as the wall material and cinnamon essential oil was used as the core material. The emulsification performance of SPICS was evaluated, and the stability of Pickering emulsion was tested. The results showed that there was hydrogen bonding between SPI and CS, and the tertiary structure of SPI was change, which enhances the hydrophobicity of SPICS surface. When the mass ratio of SPI to CS was 14:1, the emulsification activity of SPICS was 71.92 m2g-1 and its emulsion stability was 106.29%; it also had good dispersibility in water. When the volume of the oil phase was 60%, the encapsulation rate of cinnamon essential oil was 65.23%, the Pickering emulsion did not show obvious delamination for one month; and rheological tests showed the presence of shear thinning, which was judged to be a pseudoplastic fluid. Therefore, SPICS can be used as a wall material to prepare Pickering emulsion of cinnamon essential oil with good stability.

Astragaloside IV is a biologically active substance derived from the traditional Chinese medicine Astragalus mambranaceus Bunge, and has antioxidant, anti-inflammatory, and anti-apoptotic properties. In this study, we aimed to investigate the effects of astragaloside IV on Klebsiella pneumonia rats and the underlying mechanisms. Klebsiella pneumoniae (K. pneumoniae) rats were treated with different dosages of astragaloside IV (5, 10, and 20 mg/kg) by intragastric administration. The levels of pro-inflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage fluid (BALF) were determined. Pathological changes of lung tissue were inspected by HE staining. The expression of transforming growth factor (TGF)-β1 in lung tissue was determined with immunohistochemistry, and the expression levels of TGF-β1, p-Smad2/Smad2, p-Smad3/Smad3, IκBα/p-IκBα, and p65/p-p65 in lung tissue were determined by western blot. The mechanism was further investigated with TGF-β1 inhibitor SB-431542. Astragaloside IV reduced the elevated levels of pro-inflammatory cytokines caused by K. pneumoniae and improved lung tissue damage in a dose-dependent manner. Astragaloside IV also decreased the expression of TGF-β1/Smad signaling pathway-related proteins and decreased the protein levels of inflammation-related p-IκBα and p65 in lung tissues induced by K. pneumoniae. Additionally, it was found that the effects of 20 mg/kg astragaloside IV were similar to SB-431542, which could improve pulmonary fibrosis induced by K. pneumoniae, decrease the levels of TGF-β1/Smad signaling pathway-related proteins in lung, and reduce inflammation at the same time. Astragaloside IV could alleviate the inflammation of rat pneumonia induced by K. pneumoniae through suppressing the TGF-β1/Smad pathway.

Abstract Objective To explore the expression levels and clinical value of FKBP10 in lung adenocarcinoma brain metastases. Design A retrospective single-institution cohort study. Patients The perioperative records of 71 patients with lung adenocarcinoma brain metastases who underwent surgical resection at the authors’ institution between November 2012 and June 2019 were retrospectively analyzed. Methods The authors evaluated FKBP10 expression levels using immunohistochemistry in tissue arrays of these patients. Kaplan-Meier survival curves were constructed, and a Cox proportional hazards regression model was used to identify independent prognostic biomarkers. A public database was used to detect FKBP10 expression and its clinical value in primary lung adenocarcinoma. Results The authors found that the FKBP10 protein was selectively expressed in lung adenocarcinoma brain metastases. Survival analysis showed that FKBP10 expression (p = 0.02, HR = 2.472, 95% CI [1.156, 5.289]), target therapy (p < 0.01, HR = 0.186, 95% CI [0.073, 0.477]), and radiotherapy (p = 0.006, HR = 0.330, 95% CI [0.149, 0.731]) were independent prognostic factors for survival in lung adenocarcinoma patients with brain metastases. The authors also detected FKBP10 expression in primary lung adenocarcinoma using a public database, found that FKBP10 is also selectively expressed in primary lung adenocarcinoma, and affects the overall survival and disease-free survival of patients. Limitations The number of enrolled patients was relatively small and patients’ treatment options varied. Conclusions A combination of surgical resection, adjuvant radiotherapy, and precise target therapy may benefit the survival of selected patients with lung adenocarcinoma brain metastases. FKBP10 is a novel biomarker for lung adenocarcinoma brain metastases, which is closely associated with survival time and may serve as a potential therapeutic target.

ABSTRACT The objective of this study was to identify differentially expressed genes (DEG) between females and males in early bovine embryos. Superovulated cattle (n = 4) in the age span of 16–18 months were artificially inseminated with semen from the same bull that has been proven to be fertile. Blastocysts were collected by routine non-surgical uterine flushing on day 7 after insemination. This study determines the sex of embryos using a micro-injection pipette to collect a few blastomeres through the Zona pellucida. The remaining blastomeres were used for single-cell RNA sequencing (scRNA-seq) analysis on the Illumina platform, followed by differential expression analysis, Gene Ontology (GO) function analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The criteria for identifying DEG will be set at |log2(Fold change)| ≥ 1 and P<0.05. A total of 8004 DEG were detected in female (Denoted as BLX, n = 3) and male (Denoted as BLY, n = 3) blastocysts. Transcripts highly expressed in the female embryos were related to catalytic activity, nucleotide binding, and catabolic process, while transcripts highly expressed in the male embryos were linked to oxidative phosphorylation, mitochondrion, and the ribosome. Nine genes that may be involved in blastocyst growth and development were screened, suggesting that their differential expression may be responsible for the differences in the development of male and female embryos. This study provides important information on potential genes and pathways associated with differences in early female and male embryonic development.

Abstract This study focused on the effect and mechanism of Notch signal on pulmonary microvascular endothelial cells (PMVECs) following acute lung injury. PMVECs were cultured in vitro and randomly divided into eight groups. Grouping was based on whether cells were co-cultured with T cells (splenic CD4+T cells were isolated using MACS microbeads) and the level of Notch expression: Normal group and Normal+T cells group, Model group and Model+T cells group, Notch low-expression group and Notch low-expression+T cells group, and Notch overexpression group and Notch overexpression+T cells group. Except for the Normal group and Normal+T cells group, all other groups were treated with 500 μL lipopolysaccharide (1 μg/mL). The expression of VE-cadherin and Zo-1 protein in the Model group (with or without T cells) was lower than that in the normal group (with or without T cells), their expression in the Notch low-expression group (with or without T cells) was significantly increased, and their expression in the Notch overexpression group (with or without T cells) was significantly decreased. Compared with the normal+T cells group, the number of Treg cells in the Notch low-expression+T cells group decreased significantly (P<0.01). The number of Th17 cells in the Notch overexpression+T cells group was higher than that in the Model+T cells group (P<0.01), while the number of Treg cells decreased (P<0.01). Our results demonstrated that activated Notch signal can down-regulate the expression of the tight junction proteins VE-Cadherin and Zo-1 in PMVECs and affect Th17/Treg immune imbalance. Autophagy was discovered to be involved in this process.

Abstract The objective of this work was to establish and validate the dry matter distribution and yield prediction models based on physiological developmental timing, to compare the differences between the dry mass distribution index model and the dry mass distribution coefficient model, for the simulation of ear dry mass and to improve the accuracy of maize growth models for predicting yield. The experiments were conducted in three tropical sites (Longchuan, Mangshi, and Ruili) in the tropical region of Yunnan Province, China. The NRMS of ear dry mass and yield were generally less than 10. The dry mass distribution index method (NRMS = 5.44% and RMSE = 807.22 kg ha-1 for ear dry mass; and NRMS = 7.32% and RMSE = 707.67 kg ha-1 for grain yield) is better than the dry mass distribution coefficient method (NRMS = 7.52% and RMSE = 1115.31 kg ha-1 for ear dry mass; NRMS = 8.6% and RMSE = 830.76 kgha-1 for grain yield) to simulate maize ear dry mass and grain yield. The distribution index model improves the accuracy of the model, which is valuable for future maize production and management in Yunnan.

Resumo O objetivo deste trabalho foi estabelecer e validar um modelo de previsão de distribuição de massa de matéria seca e de rendimento, com base no tempo de desenvolvimento fisiológico, para comparar as diferenças entre o modelo de índice de distribuição de matéria seca e o modelo de coeficiente de distribuição de matéria seca, para a simulação da massa de matéria seca da espiga e para melhorar a precisão de modelos de crescimento do milho para a previsão de rendimento. Os experimentos foram realizados em três locais (Longchuan, Mangshi e Ruili), na região tropical da província de Yunnan, China. O NRMS da massa de matéria seca e o rendimento da espiga foram geralmente menores que 10. O método do índice de distribuição da massa de matéria seca (NRMS = 5,44% e RMSE = 807,22 kg ha-1 para massa de matéria seca da espiga; e o NRMS = 7,32% e RMSE = 707,67 kg ha-1 para rendimento de grãos) é melhor do que o método do coeficiente de distribuição de massa de matéria seca (NRMS = 7,52% e RMSE = 1115,31 kg ha-1 para massa de matéria seca de espiga; NRMS = 8,6% e RMSE = 830,76 kg ha-1 para rendimento de grãos) para a simulação da massa de matéria seca de espiga e o rendimento de grãos de milho. O modelo do índice de distribuição melhora a precisão do modelo, o que é valioso para o futura produção de milho e seu manejo em Yunnan.

Abstract Objective The study explored improvements in pulmonary inflammation and fibrosis in a bovine type II collagen-induced rheumatoid arthritis-associated interstitial lung disease mouse model after treatment with baricitinib and the possible mechanism of action. Methods A rheumatoid arthritis-associated interstitial lung disease mouse model was established, siRNA Jak2 and lentiviral vectors were transfected with human embryonic lung fibroblast cells. And the levels of relevant proteins in mouse lung tissue and human embryonic lung fibroblasts were detected by Western blotting. Results The levels of JAK2, p-JAK2, p-STAT3, p-SMAD3, SMA, TGFβR2, FN and COL4 were increased in the lung tissues of model mice (P < 0.5) and decreased after baricitinib intervention (P < 0.05). The expression levels of p-STAT3, p-SMAD3, SMA, TGFβR2, FN and COL4 were reduced after siRNA downregulation of the JAK2 gene (P < 0.01) and increased after lentiviral overexpression of the JAK2 gene (P < 0.01). Conclusion Baricitinib alleviated fibrosis in the lung tissue of rheumatoid arthritis-associated interstitial lung disease mice, and the mechanism of action may involve the downregulation of Smad3 expression via inhibition of the Jak2/Stat3 signaling pathway, with consequent inhibition of the profibrotic effect of transforming growth factor-β1.

ABSTRACT In order to estimate the adaptability of Agricultural Production Systems Simulator (APSIM)-Maize model under the special climate environment in tropic, 10 field experiments were conducted at different seasons in three sites (Longchuan, Mangshi and Ruili) of tropic in Yunnan Province, China. The parameters of APSIM model were calibrated and its adaptability was validated. The results showed that the days from sowing to flowering and sowing to maturity were predicted accurately for all sites with mean errors of 2.0 ± 0.4, and 3.2 ± 0.7 d respectively. The normalized root mean square errors (NRMSE) of the model for yield prediction were 2%, 3% and 5% for each of three sites, respectively, which indicated that the APSIM model had good accuracy and sensitivity in predicting phenological phases and yield of maize (Zea mays L.) grown in different seasons, and the model had good adaptability in the tropic of Southwest China. This study provided the basis and technical support for evaluating maize production potential based on the model.

Abstract Introduction: type 2 diabetes (T2DM) is a complex disease affected by lifestyle and genetic factors. Although the drugs currently used to treat T2DM have certain curative effects, they still have some adverse side effects. Therefore, it is urgent to find new effective drugs with few side effects to cure T2DM. Objective: to study the role of Inonotus obliquus (IO) in diabetic model mice. Methods: we used high-fat diet (HFD) combined with streptozocin (STZ) to establish a diabetic mouse model. Mice were divided into non-high-fat diet group (ND), diabetes model group (HFD + STZ) and IO-treated diabetes model group (IO). The mice in the IO group were orally treated with IO (150 mg/kg) at 10 ml/kg for five weeks. Body weight, glucose level, food intake and water consumption, glucose tolerance and insulin tolerance were evaluated in all mice. The pathological sections of liver, kidney and pancreas were observed by hematoxylin-eosin staining. Results: after IO administration, the blood glucose level, water consumption, low-density lipoprotein (LDL) and triacylglycerol (TG) levels of mice decreased. Compared with the HFD + STZ group, the number of normal islet iiiiiiii cells increased and focal necrosis of the liver was significantly reduced in the IO administration group. Conclusions: IO reduced the levels of blood glucose, restored body weight, and enhanced insulin sensitivity along with insulin tolerance and glucose tolerance in diabetic mice. Additionally, IO also reversed HFD and STZ-induced organ injury.

Resumen Introducción: la diabetes mellitus tipo 2 (T2DM) es una enfermedad compleja influenciada por el estilo de vida y los factores genéticos. En la actualidad, aunque los medicamentos para la diabetes tipo 2 tienen cierto efecto curativo, todavía tienen algunos efectos secundarios. Por lo tanto, es urgente encontrar nuevos medicamentos para la diabetes tipo 2 que tengan un buen efecto curativo y menos efectos secundarios. Objetivo: estudiar el papel del Inonotus obliquus (IO) en ratones diabéticos. Métodos: se estableció un modelo de ratón diabético con dieta de alto contenido en grasas (HFD) y estreptozocina (STZ). Los ratones se dividieron en el grupo de dieta no alta en grasas (ND), el grupo modelo de diabetes mellitus (HFD + STZ) y el grupo modelo de diabetes mellitus tratado con IO. Los ratones del grupo IO recibieron 10 ml/kg de IO (150 mg/kg) durante cinco semanas. Se observaron el peso corporal, el nivel de azúcar en sangre, la ingesta de alimentos, la ingesta de agua potable, la tolerancia a la glucosa y la tolerancia a la insulina de los ratones de cada grupo, y se estudiaron muestras de biopsias hepáticas, renales y pancreáticas mediante tinción de hematoxilina eosina. Resultados: los niveles de glucosa en sangre, el consumo de agua, la lipoproteína de baja densidad (LDL) y los triglicéridos (TG) disminuyeron después de la administración de IO. En comparación con el grupo HFD+STZ, el número de células β pancreáticas normales y la necrosis focal hepática disminuyeron significativamente en el grupo IO. Conclusiones: el IO redujo el nivel de glucosa en sangre, ayudó a recuperar el peso corporal y mejorar la sensibilidad a la insulina, la tolerancia a la insulina y la tolerancia a la glucosa en ratones diabéticos. Además, el IO revirtió el daño orgánico inducido por HFD y STZ.

RESUMO Introdução: A comunidade acadêmica tem demonstrado a ligação do desempenho em pistas e campo com os principais fatores de treinamento esportivo, incluindo a psicologia da competição. Em pesquisas recentes, foi verificado que o nível do desempenho atlético também está relacionado à altitude, ao clima, ao ambiente do local e ao cronograma da competição. Até o momento não existem estudos para proporcionar experiência teórica e prática de treinamento no ambiente regional de Ganzhou. Objetivo: Este artigo analisa a influência do treinamento em altitude sobre o desempenho dos profissionais de atletismo. Ao mesmo tempo, analisamos os indicadores fisiológicos e bioquímicos dos atletas. Métodos: Vários corredores de longa distância tiveram um treinamento de altitude de ٨ semanas. Analisamos os indicadores fisiológicos e bioquímicos dos atletas antes e depois do treinamento. Ao mesmo tempo, realiza análises matemáticas-estatísticas sobre o desempenho dos corredores de longa distância, antes e depois do treinamento. Resultados: Após o treinamento de altitude, a hemoglobina e os glóbulos vermelhos apresentaram diminuição significativa (P<0,01). Após o treinamento, o desempenho dos atletas melhorou consideravelmente (P<0,01). Conclusão: O treinamento em diferentes altitudes pode promover uma curva ascendente no desempenho dos atletas até seu platô, na quarta semana de treino. Nível de evidência II; Estudos Terapêuticos - Investigação de Resultados.

ABSTRACT Introduction: The academic community has demonstrated the link of athletic performance in track and field with critical factors of sports training, including the psychology of competition. Recently, research has been verified that athletic performance is also related to altitude, weather, ambiance, and the timing of the competition. There are no studies to provide theoretical and practical training experience in the regional environment of Ganzhou. Objective: This paper analyzes the influence of altitude training in professional performance athletes. Concurrently, analysis of the physiological and biochemical indicators of the athletes is performed. Methods: Several long-distance runners had an 8-week altitude training. Analyzed the physiological and biochemical indicators of the athletes before and after the training. At the same time, perform mathematical-statistical analysis on the performance of long-distance runners before and after training. Results: After altitude training, hemoglobin and red blood cells showed a significant decrease (P<0.01). After training, athletes’ performance improved considerably (P<0.01). Conclusion: Training at different altitudes may promote an ascending curve in the athletes’ performance until a plateau in the fourth week of training. Evidence Level II; Therapeutic Studies - Investigating the result.

RESUMEN Introducción: La comunidad académica ha demostrado la relación del rendimiento deportivo en el atletismo con los principales factores del entrenamiento deportivo, incluida la psicología de la competición. En investigaciones recientes, se ha descubierto que el nivel de rendimiento deportivo también está relacionado con la altitud, el clima, el entorno del lugar y el horario de la competición. Hasta la fecha, no existen estudios que proporcionen una experiencia de formación teórica y práctica en el entorno regional de Ganzhou. Objetivo: Este trabajo analiza la influencia del entrenamiento en altitud en el rendimiento de los atletas profesionales de atletismo. Al mismo tiempo, analizamos los indicadores fisiológicos y bioquímicos de los atletas. Métodos: Varios corredores de larga distancia se sometieron a un entrenamiento en altitud de 8 semanas. Analizamos los indicadores fisiológicos y bioquímicos de los atletas antes y después del entrenamiento. Al mismo tiempo, realice un análisis matemático-estadístico sobre el rendimiento de los corredores de fondo antes y después del entrenamiento. Resultados: Tras el entrenamiento en altitud, la hemoglobina y los glóbulos rojos mostraron un descenso significativo (P<0,01). Tras el entrenamiento, el rendimiento de los atletas mejoró considerablemente (P<0,01). Conclusión: El entrenamiento en diferentes altitudes puede promover una curva ascendente en el rendimiento de los atletas hasta su meseta, en la cuarta semana de entrenamiento. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.

Abstract Background Brain natriuretic peptide (BNP) and troponin have a close relationship with cardiogenic cerebral embolism (CCE), but their relationship with noncardiogenic patients with anterior circulation ischemia (ACI) and posterior circulation ischemia (PCI) is not clear. Objective To explore the predictive value of serum initial BNP and troponin on the functional prognosis of patients with noncardiogenic ACI and PCI. Methods Consecutive patients with first-episode cerebral infarction within 12 hours of symptom onset were enrolled in the present 1-year prospective cohort study. Serum levels of BNP and troponin were collected within 12 hours of onset. Infarction location was classified as ACI and PCI by magnetic resonance imaging (MRI). According to the modified Rankin Scale (mRS) score at 90 days after onset, ACI and PCI cases were respectively divided into a good prognosis group (mRS score between 0 and 2) and a poor prognosis group (mRS score between 3 and 6). The general state of health and results of laboratory examinations and other auxiliary examinations of all patients were recorded. Single-factor analysis and multivariate logistic regression analysis were used to assess the relationship between serum levels of BNP, troponin, and functional outcome. Results The multivariate logistic regression found that higher levels of initial BNP (odds ratio [OR] = 1.024; 95% confidence interval [CI]: 1.006–1.041; p = 0.007) and C-reactive protein (CRP) (OR = 1.184; 95%CI: 1.024–1.369; p = 0.022) were independent predictors of poor functional prognosis of noncardiogenic PCI at 90 days after onset after adjusting for age, gender, ethnicity, history of hypertension and of diabetes. Conclusions The levels of initial BNP and CRP were related to poor functional outcomes in noncardiogenic PCI patients at 3 months, independent of troponin.

Resumo Antecedentes O peptídeo natriurético cerebral (BNP, na sigla em inglês) e a troponina estão intimamente relacionados com a embolia cerebral cardiogênica (CCE, na sigla em inglês), mas a relação com pacientes não cardioembólicos com isquemia de circulação anterior (ICA) e isquemia de circulação posterior (ICP) não é clara. Objetivo Investigar o valor preditivo dos níveis séricos iniciais do BNP e da troponina no prognóstico de pacientes com AVC isquêmico não cardiogênico. Métodos Os níveis séricos de BNP e de troponina foram recolhidos de pacientes com primeiro episódio de acidente vascular cerebral (AVC) isquêmico dentro de 12 horas após o início dos sintomas, com localização classificada como ICA e ICP de acordo com exame de ressonância magnética (RM). De acordo com a pontuação modificada da escala de Rankin (mRS), aos 90 dias após o início dos sintomas, ICA e ICP foram divididas respectivamente em um grupo de bom prognóstico (mRS entre 0 e2) e em um grupo de mau prognóstico (mRS entre 3 e 6). Foram registrados exames laboratoriais e outros exames complementares de todos os pacientes. Foram utilizadas análise fatorial única e análise de regressão logística multivariada para investigar a relação entre os níveis séricos de BNP e de troponina e o resultado funcional. Resultados A regressão logística multivariada evidenciou que os níveis mais altos de BNP inicial (odds ratio [OR] = 1,024, intervalo de confiança [IC] de 95%: 1,006–1,041; p = 0,007) e proteína C reativa (CRP, na sigla em inglês) (OR = 1,184; 95%CI: 1,024–1,369; p = 0,022) foram preditores independentes de mau prognóstico funcional da ICP não cardiogênica aos 90 dias após o início dos sintomas. Conclusões Os níveis iniciais de BNP e CRP se associaram a maus resultados funcionais em pacientes com ICP não cardiogênica aos três meses, independentemente da troponina.