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Cerebrospinal fluid: a target of some fungi and an overview
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Corrêa-Moreira, Danielly

; Castro, Rodolfo

; da Costa, Gisela Lara

; Lima-Neto, Reginaldo Gonçalves

; Oliveira, Manoel Marques Evangelista

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220251

Resumo: En | Texto: En | PDF: En

Meningitis is a potentially life-threatening infection characterised by the inflammation of the leptomeningeal membranes. The estimated annual prevalence of 8.7 million cases globally and the disease is caused by many different viral, bacterial, and fungal pathogens. Although several genera of fungi are capable of causing infections in the central nervous system (CNS), the most significant number of registered cases have, as causal agents, yeasts of the genus Cryptococcus. The relevance of cryptococcal meningitis has changed in the last decades, mainly due to the increase in the number of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and medications that impair the immune responses. In this context, coronavirus disease 19 (COVID-19) has also emerged as a risk factor for invasive fungal infections (IFI), including fungal meningitis (FM), due to severe COVID-19 disease is associated with increased pro-inflammatory cytokines, interleukin (IL)-1, IL-6, and tumour necrosis factor-alpha, reduced CD4-interferon-gamma expression, CD4 and CD8 T cells. The gold standard technique for fungal identification is isolating fungi in the culture of the biological material, including cerebrospinal fluid (CSF). However, this methodology has as its main disadvantage the slow or null growth of some fungal species in culture, which makes it difficult to finalise the diagnosis. In conclusions, this article, in the first place, point that it is necessary to accurately identify the etiological agent in order to assist in the choice of the therapeutic regimen for the patients, including the implementation of actions that promote the reduction of the incidence, lethality, and fungal morbidity, which includes what is healthy in the CNS.

https://doi.org/10.1590/0074-02760220251

Design, Synthesis and Antifungal Activity of New Schiff Bases Bearing 2-Aminothiophene Derivatives Obtained by Molecular Simplification
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Luna, Isadora S.

; Neves, Wendell W.

; Lima-Neto, Reginaldo G. de

; Albuquerque, Amanda P. B.

; Pitta, Maíra G. R.

; Rêgo, Moacyr J. B. M.

; Neves, Rejane P.

; Scotti, Marcus T.

; Mendonça-Junior, Francisco J. B.

Journal of the Brazilian Chemical Society

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Mai 2021, Volume 32 Nº 5 Páginas 1017 - 1029

Resumo: En | Texto: En | PDF: En

Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their druglikeness and pharmacokinetic properties, establishment of their structure-activity relationships (SAR), and cytotoxic evaluation of the most active compounds were performed. Using an eco-friendly procedure, microwave assisted synthesis resulted in compounds in good yields (35-85%). Compounds 4a-4q presented good druglikeness and pharmacokinetic profiles and no cytotoxicity for any cell line tested up to 100 µM. The compounds presenting the best antifungal profiles were 4e, 4f, 4g, 4k, 4l, 4m, 4o and 4p with more than one minimum inhibitory concentration (MIC) value occurring between 16-64 µg mL-1, thus, in some cases better than the reference drug (fluconazole). SAR testing indicated that the presence of halogens and nitro substituents increases antifungal activity. Taken together, the results demonstrate that 2-aminothiophene derivatives are promising lead compounds for the development of antifungal drugs.

https://doi.org/10.21577/0103-5053.20210004 163 downloads

Analyses of the response of carbapenem-resistant Pseudomonas aeruginosa against monotherapy and combined therapy using quantum dots and proteomics
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LIMA, JAILTON L.C.

; PEREIRA, JUSSYÊGLES N.P.

; RAPOSO, BRUNO L.

; FONTES, ADRIANA

; CABRAL FILHO, PAULO E.

; LIMA NETO, REGINALDO G.

; XIMENES, RAFAEL M.

; MACIEL, MARIA AMÉLIA V.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20210823

Resumo: En | Texto: En | PDF: En

Abstract Carbapenem-resistant P. aeruginosa (CRPA) has become a serious public health problem and the biofilm formation aggravates this problem. The study aimed to evaluate the occurrence of β-lactamases and quorum sensing (QS) genes in CRPA isolates, analyze production of biofilm, evaluate the response against meropenem (MPM) and∕or polymyxin B (POL B) and its association with azythromicin (AZT) using quantum dots (QDs) and proteomic analysis. Six CRPA isolates were analyzed. β-lactamases and QS genes were search using specific PCRs and were tested for biofilm production by quantitative technique. A CRPA isolate, containing blaKPC gene and biofilm-producing, was selected to assess its response to therapy using QDs and the MALDI-TOF. The β-lactamase detected was blaKPC in 66.7% of the isolates. All isolates were biofilm producers and carriers of the QS genes. QDs-MPM conjugates triggered the formation of biofilm and the association with AZT inhibited this effect. Proteomics analysis showed that treatments with MPM or POL B suppressed the expression of the transglycosylase protein, while combined therapy with AZT induced expression of the RpoN protein. Thus, this study shows that the use of fluorescence combined with the proteomics analysis was promising to understand how a CRPA strain reacts to antimicrobial treatment.

https://doi.org/10.1590/0001-3765202120210823 1 downloads

Coccidioidomycosis: first cases reported in Pernambuco, Brazil
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Araújo, Paulo Sergio Ramos de

; Souza Junior, Valter Romão de

; Padilha, Carlos Eduardo

; Oliveira, Marta Iglis de

; Arraes, Luciana Cardoso

; Vieira, Roberto

; Antunes, Ana

; Lima Neto, Reginaldo Goncalves de

; Marsden, Armando

Revista do Instituto de Medicina Tropical de São Paulo

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2018, Volume 60 elocation e75

Resumo: En | Texto: En | PDF: En

ABSTRACT Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. The first cases of coccidioidomycosis in Brazil were reported in 1978. Since then, there have been other reports mainly from desert regions of Northeastern Brazil. The present report describes three cases of coccidioidomycosis on male farmers from Serra Talhada county, Pernambuco State, who developed pneumonia and were subsequently diagnosed with pulmonary coccidioidomycosis. These three farmers were successfully treated with oral fluconazole. They reported having hunted armadillos in a rural and arid area of Pernambuco State. Armadillos are known to be carriers of Coccidioides. This is the first report of infection caused by Coccidioides in Pernambuco State, Brazil.

https://doi.org/10.1590/s1678-9946201860075 1089 downloads

Improvement of Solubility and Antifungal Activity of a New Aminothiophene Derivative by Complexation with 2-Hydroxypropyl-β-cyclodextrin
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Eleamen, Giovanna R. A.

; Costa, Silvana C. da

; Lima-Neto, Reginaldo G.

; Neves, Rejane P.

; Rolim, Larissa A.

; Rolim-Neto, Pedro J.

; Moura, Ricardo O.

; Aquino, Thiago M. de

; Bento, Edson S.

; Scotti, Marcus T.

; Mendonça-Junior, Francisco J. B.

; Mendonça, Elisangela A. M.

; Oliveira, Elquio E.

Journal of the Brazilian Chemical Society

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Jan 2017, Volume 28 Nº 1 Páginas 116 - 125

Resumo: En | Texto: En | PDF: En

This study aimed to prepare a complex of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and 6CN10, a poorly water soluble 2-aminothiophene derivative with antifungal properties, by freeze-drying technique. The complex was characterized by thermal analysis, infrared/Raman spectroscopy, X-ray diffraction and scanning electron microscopy. In addition, we used the data of the phase solubility study, 1H, and 2D NMR spectroscopy and molecular modeling in order to investigate the interactions between 6CN10 and HP-β-CD. The apparent solubility of 6CN10 with HP-β-CD increased more than 29 fold. The phase solubility assay in water at 25 ºC showed an AP-type curve, with an apparent stability constant K1:1 and K1:2 of 96 and 0.1989 M-1, respectively. The results of IR, NMR and docking indicate that 6CN10 is able to form complexes with HP-β-CD (1:1 and 1:2 stoichiometric ratios), generating the formation of inclusion and preferably, non-inclusion complexes. The antifungal activity against Cryptococcus neoformans demonstrated the superior performance of the complex (46.66 µg mL-1) when compared with the free drug (166.66-333.33 µg mL-1). The present study provides useful information for the potential application of complexation with low soluble compounds and about the type of complex formation between 6CN10 and HP-β-CD.

https://doi.org/10.5935/0103-5053.20160153 1474 downloads

Cryptococcus laurentii fungaemia in a cervical cancer patient
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Neves, Rejane Pereira

; Lima Neto, Reginaldo Gonçalves de

; Leite, Melyna Chaves

; Silva, Vanessa Karina Alves da

; Santos, Franz de Assis Graciano dos

; Macêdo, Danielle Patrícia Cerqueira

Brazilian Journal of Infectious Diseases

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Dez 2015, Volume 19 Nº 6 Páginas 660 - 663

Resumo: En | Texto: En | PDF: En

ABSTRACT Infections caused by emerging Cryptococcus non-neoformans species are being reported with increasingly frequency. Here, we present a case of fungaemia byCryptococcus laurentii in a woman receiving aggressive immunosuppressive therapy for cervical neoplasia. Three venous blood samples were aseptically collected on consecutive days and C. laurentiiwas isolated and identified through phenotypic and molecular methods. After central venous catheter removal and appropriate antifungal therapy, the patient showed significant improvement and blood culture became negative. Thus, patients following immunosuppressive therapies and using invasive medical devices are at risk of C. laurentii blood infections.

https://doi.org/10.1016/j.bjid.2015.06.014 1972 downloads

Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies
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Parahym, Ana Maria Rabelo de Carvalho

; Rolim Neto, Pedro José

; Silva, Carolina Maria da

; Domingos, Igor de Farias

; Gonçalves, Sarah Santos

; Leite, Edinalva Pereira

; Morais, Vera Lúcia Lins de

; Macêdo, Danielle Patrícia Cerqueira

; Lima Neto, Reginaldo Gonçalves de

; Neves, Rejane Pereira

Brazilian Journal of Microbiology

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Jun 2015, Volume 46 Nº 2 Páginas 527 - 530

Resumo: En | Texto: En | PDF: En

We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.

https://doi.org/10.1590/S1517-838246220120447 2279 downloads

Application of MALDI-TOF MS for requalification of a Candida clinical isolates culture collection
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Lima-Neto, Reginaldo

; Santos, Cledir

; Lima, Nelson

; Sampaio, Paula

; Pais, Célia

; Neves, Rejane P.

Brazilian Journal of Microbiology

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Jun 2014, Volume 45 Nº 2 Páginas 515 - 522

Resumo: En | Texto: En | PDF: En

Microbial culture collections underpin biotechnology applications and are important resources for clinical microbiology by supplying reference strains and/or performing microbial identifications as a service. Proteomic profiles by MALDI-TOF MS have been used for Candida spp. identification in clinical laboratories and demonstrated to be a fast and reliable technique for the routine identification of pathogenic yeasts. The main aim of this study was to apply MALDI-TOF MS combined with classical phenotypic and molecular approaches to identify Candida clinical isolates preserved from 1 up to 52 years in a Brazilian culture collection and assess its value for the identification of yeasts preserved in this type of collections. Forty Candida spp. clinical isolates were identified by morphological and biochemical analyses. Identifications were also performed by the new proteomic approach based on MALDI-TOF MS. Results demonstrated 15% discordance when compared with morphological and biochemical analyses. Discordant isolates were analysed by ITS sequencing, which confirmed the MALDI-TOF MS identifications and these strains were renamed in the culture collection catalogue. In conclusion, proteomic profiles by MALDI-TOF MS represents a rapid and reliable method for identifying clinical Candida species preserved in culture collections and may present clear benefits when compared with the performance of existing daily routine methods applied at health centres and hospitals.

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II Diretriz Brasileira de Transplante Cardíaco
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Bacal, Fernando

; Souza Neto, João David de

; Fiorelli, Alfredo Inácio

; Mejia, Juan

; Marcondes-Braga, Fabiana Goulart

; Mangini, Sandrigo

; Oliveira Jr, José de Lima

; Almeida, Dirceu Rodrigues de

; Azeka, Estela

; Dinkhuysen, Jarbas Jakson

; Moreira, Maria da Consolação Vieira

; Rossi Neto, João Manoel

; Bestetti, Reinaldo Bulgarelli

; Fernandes, Juliana Rolim

; Cruz, Fátima das Dores

; Ferreira, Lucinei Paz

; Costa, Helenice Moreira da

; Pereira, Ana Augusta Maria

; Panajotopoulos, Nicolas

; Benvenuti, Luiz Alberto

; Moura, Lídia Zytynski

; Vasconcelos, Glauber Gean

; Branco, João Nelson Rodrigues

; Gelape, Claudio Leo

; Uchoa, Ricardo Barreira

; Ayub-Ferreira, Silvia Moreira

; Camargo, Luis Fernando Aranha

; Colafranceschi, Alexandre Siciliano

; Bordignon, Solange

; Cipullo, Reginaldo

; Horowitz, Estela Suzana Kleiman

; Branco, Klébia Castelo

; Jatene, Marcelo

; Veiga, Sergio Lopes

; Marcelino, Cesar Augusto Guimarães

; Teixeira Filho, Guaracy Fernandes

; Vila, José Henrique

; Montera, Marcelo Westerlund

Arquivos Brasileiros de Cardiologia

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2010, Volume 94 Nº 1 Páginas e16 - e76

Resumo: Pt | Texto: Pt | PDF: Pt

103007 downloads Citado 7 vezes em SciELO

10.

Infecções oportunistas por leveduras e perfil enzimático dos agentes etiológicos
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Macêdo, Danielle Patrícia Cerqueira

; Farias, Aline Mary de Almeida

; Lima Neto, Reginaldo Gonçalves de

; Silva, Vanessa Karina Alves da

; Leal, André Ferraz Goiana

; Neves, Rejane Pereira

Revista da Sociedade Brasileira de Medicina Tropical

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Abr 2009, Volume 42 Nº 2 Páginas 188 - 191

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Infecções por leveduras são freqüentes em imunocomprometidos, contudo espécies emergentes têm alterado o perfil epidemiológico. A habilidade de secretar proteases tem sido associada à patogenicidade do gênero Candida. Esta pesquisa teve como objetivos diagnosticar leveduroses em pacientes imunocomprometidos e avaliar a virulência dos agentes etiológicos baseado em teste de secreção de protease utilizando soro de albumina bovina como substrato. Do total de 104 pacientes estudados, 19 apresentaram episódios de leveduroses. O trato respiratório (63,2%), seguido pelo trato urinário (10,5%) foram os locais mais comuns de infecção. Candida albicans, Candida parapsilosis, Candida tropicalis e espécies emergentes como Candida krusei e Candida guilliermondii foram isoladas. Cinco isolados de Candida parapsilosis e um de Candida albicans e Candida guilliermondii exibiram alta atividade enzimática. Concluímos que a caracterização enzimática de isolados de Candida pode ser um útil marcador prognóstico, especialmente em imunocomprometidos, uma vez que leveduroses nestes pacientes são geralmente graves.

Yeast infections are common in immunocompromised patients, although emerging species have been changing the epidemiological profile. The ability to secrete proteinases has been associated with pathogenicity within the genus Candida. This study had the aims of diagnosing yeast infections in immunocompromised patients and evaluating the virulence of the etiological agents, based on a proteinase secretion assay using bovine serum albumin as a substrate. Out of a total of 104 patients studied, 19 presented episodes of yeast infection. The respiratory tract (63.2%), followed by the urinary tract (10.5%), were the most common sites of infection. Candida albicans, Candida parapsilosis, Candida tropicalis and emerging species such as Candida krusei and Candida guilliermondii were isolated. Five isolates of Candida parapsilosis and one of Candida albicans and Candida guilliermondii exhibited high enzymatic activity. We conclude that enzymatic characterization of Candida isolates may be a useful prognostic marker, especially among immunocompromised individuals, since yeast infections in such patients are generally serious.

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