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Sustainable supply chain management in a global context: the perspective of emerging economy suppliers
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Pereira, Michele Morais O.

; Hendry, Linda C.

; Silva, Minelle E.

; Bossle, Marilia Bonzanini

; Antonialli, Luiz Marcelo

RAUSP Management Journal

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Set 2023, Volume 58 Nº 3 Páginas 197 - 218

Resumo: En | Texto: En | PDF: En

Abstract Purpose This paper aims to investigate how the extant literature on sustainable supply chain management (SSCM) empirically explores the perspective of emerging economy suppliers operating in global supply chains (GSCs). It thereby explains the role of emerging economy suppliers in determining the success of SSCM. Design/methodology/approach A systematic literature review of 41 empirical papers (published between 2007 and 2021) was conducted, involving both descriptive and thematic analyses. Findings The findings demonstrate that emerging economy suppliers have a key role in SSCM, given their use of positive feedback loops to proactively create remedies to surpass barriers using their collaboration mechanisms, and exploit authentic sustainability outcomes as reinforcements to drive further sustainability initiatives. The authors also demonstrate that suppliers are particularly focused on the cultural and institutional dimensions of sustainability. Finally, the authors provide an explanatory analytical framework to reduce the institutional distance between buyers and their global suppliers. Research limitations/implications This review identifies avenues for future research on the role of emerging economy suppliers in SSCM. Practical implications Recognising remedies to surpass barriers and reinforcements to drive new actions can aid SSCM in GSCs and improve understanding between buyers and suppliers. Social implications The valorisation of cultural and institutional issues can lead to more responsible supplier interactions and improved sustainability outcomes in emerging economies. Originality/value This review only analyses the viewpoint of emerging economy suppliers, whereas prior SSCM reviews have focused on the buyer perspective. Thus, the authors reduce supplier invisibility and institutional distance between GSC participants.

https://doi.org/10.1108/rausp-05-2022-0141

Electrospun PHBV nanofiber containing Tea Tree Oil: physicochemical and antimicrobial activity
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Santos, Verônica Ribeiro dos

; Vera, Samara Domingues

; Cena, Gabrielle Lupeti de

; Silva, Adrielle de Paula

; Lemes, Ana Paula

; Conceição, Kátia da

; Tada, Dayane Batista

; Borges, Alexandre Luiz Souto

; Trichês, Eliandra de Sousa

Polímeros

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2023, Volume 33 Nº 1 elocation e20230004

Resumo: En | Texto: En | PDF: En

Abstract Aiming to produce an antimicrobial dressing for wound healing applications, in this work Tea Tree oil (TTO) was incorporated into PHBV nanofibers by absorption. It was observed increase in the nanofiber diameter due to 5% TTO absorption efficiency, which also led to a 54% decrease in the contact angle. The releasing assay indicates a 6.8% oil release in the first 24 h – being probably the oil deposited at the polymer surface – followed by a minimal release at 48 h. The set of antimicrobial assays performed suggests the incorporation of TTO optimized the antimicrobial activity of the polymer for E. coli and C. albicans, while against S. aureus no significant difference was observed. The MTT assay showed no cytotoxicity of PHBV, but the incubation of L929 fibroblast cells with PHBV-TTO reduced cell viability. Overall, the PHBV nanofibers containing TTO present great potential as an antimicrobial dressing.

https://doi.org/10.1590/0104-1428.20220088

Active antimicrobial extruded films for mozzarella cheese from poly (butylene adipate co-terephthalate) (PBAT) and orange oil
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Andrade, Michelle Félix de

; Silva, Ivo Diego de Lima

; Caetano, Viviane Fonseca

; Silva, Gisely Alves da

; Moraes Filho, Luiz Emílio Pessoa Timeni de

; Almeida, Yêda Medeiros Bastos de

; Vinhas, Glória Maria

Polímeros

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2023, Volume 33 Nº 2 elocation e20230017

Resumo: En | Texto: En | PDF: En

Abstract The use of natural antimicrobial additives, such as orange essential oil (OO), can be a promising possibility to increase food shelf life with the aid of active packaging. This study aimed to develop an active packaging using orange oil and PBAT - poly (butylene adipate co- terephthalate) to store mozzarella cheese produced by a fine film extruder with 5, 10, and 15% OO (w/w). In the results, D-limonene was oil’s main constituent with antimicrobial activity against E. aerogenes, E. coli, and S. aureus. The addition of the oil did not alter the thermal stability of the film. The water vapor permeability increased with increasing oil concentration. All films presented high strength. However, films with higher OO concentrations favored the degradation process, as observed in the activation energy. The active packaging added with 15% OO (PBAT15) was efficient, reducing microbial growth up to 6 days of storage of mozzarella cheese.

https://doi.org/10.1590/0104-1428.20220112

Physicochemical characteristics of tomato fruits for industrial processing according to the irrigation management
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Silva, Cícero J. da

; Silva, César A. da

; Rodrigues, Rhayf E.

; Pontes, Nadson de C.

; Silva, Luiz F. M. da

; Megguer, Clarice A.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Jul 2022, Volume 26 Nº 7 Páginas 513 - 519

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A pesquisa objetivou avaliar a qualidade pós-colheita de frutos de tomateiro para processamento industrial, submetido a lâminas de irrigação e períodos de corte de irrigação antes da colheita, irrigado por gotejamento subterrâneo em áreas de Cerrado na região Sul de Goiás, Brasil, nos anos de 2015 e 2016. Os experimentos foram instalados no delineamento em blocos ao acaso, com quatro repetições, em parcelas subdivididas. Nas parcelas avaliaram-se cinco lâminas de irrigação (50, 75, 100, 125 e 150% da evapotranspiração da cultura) e nas subparcelas cinco períodos de suspensão da irrigação (0, 7, 14, 21 e 28 dias antes da colheita). Após a colheita, que ocorreu aos 125 dias após o transplantio das mudas, foram avaliados a massa média de frutos, o formato dos frutos (diâmetro longitudinal e transversal), teor de sólidos solúveis totais, acidez titulável, pH, firmeza, rendimento de polpa e produtividade da água para rendimento de polpa. A irrigação deficitária, com reposição menor que 100% da evapotranspiração da cultura, permitiu economizar água, mas reduziu significativamente o tamanho dos frutos e o rendimento de polpa. A suspensão da irrigação em antecedência à colheita diminuiu o rendimento de polpa e o tamanho dos frutos. As maiores produtividades da água para rendimento de polpa dos frutos de tomateiro ocorreram sob déficit hídrico com 50% da evapotranspiração da cultura. Lâminas de irrigação de 50 a 150% da evapotranspiração da cultura e a suspensão da irrigação antes da colheita não influenciaram os teores de sólidos solúveis totais, pH e firmeza dos frutos.

ABSTRACT This study was carried out to evaluate the postharvest quality of processing tomato fruits, submitted to irrigation depths and periods of suspension of irrigation before harvest, irrigated by subsurface drip in Cerrado areas in the southern region of Goiás State, Brazil, in 2015 and 2016. The experiments were established under a randomized block design, with four replicates arranged in a split plots scheme. In the plots, five irrigation depths were evaluated (50, 75, 100, 125 and 150% of the crop evapotranspiration) and, in the subplots, five periods of suspension of irrigation (0, 7, 14, 21 and 28 days before harvest) were assessed. After harvesting, which occurred at 125 days after transplanting the seedlings, the average fruit mass, fruit shape (longitudinal and transversal diameter), total soluble solids content, titratable acidity, pH, firmness, pulp yield, and water productivity for pulp yield were evaluated. Irrigation deficit, with the replacement of less than 100% of crop evapotranspiration, allowed to save water but significantly reduced the size of the fruits and the production of concentrated pulp. The suspension of irrigation before harvest decreased pulp yield and fruit size. The highest water productivity for pulp yield of tomato fruits occurred under water deficit with 50% of crop evapotranspiration. Irrigation depths from 50 to 150% of crop evapotranspiration and suspension before harvest does not influence total soluble solids content, pH, and fruit firmness.

https://doi.org/10.1590/1807-1929/agriambi.v26n7p513-519

Changing Escherichia coli susceptibility and increasing antimicrobial resistance in community urinary tract infections
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Fernandes da Silva, André Luiz

; Severino Pereira, Milca

; Silva Souza, Adenícia Custódia

; Cardoso Marinho, Larissa

; Pereira Vieira Barreto, Nilo Manoel

; Rodrigues do Carmo Filho, José

Revista Cubana de Medicina General Integral

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Mar 2022, Volume 38 Nº 1 elocation e1643

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

RESUMEN Introducción: Las infecciones del tracto urinario causadas por bacterias gramnegativas resistentes a los antibióticos son una preocupación creciente debido a las limitadas opciones terapéuticas. Objetivo: Analizar la tendencia de resistencia a los antibióticos en Escherichia coli resistente a la ciprofloxacina aislada de la infección del tracto urinario adquirida en la comunidad. Métodos: Estudio de series de tiempo que analiza registros de urocultivos positivos para E. coli resistente a ciprofloxacina en personas de ≥18 años de 2011 a 2017. Las tendencias en los patrones de resistencia a los antibióticos se obtuvieron mediante la regresión lineal generalizada de Prais-Winsten. El cambio porcentual anual (APC) y el intervalo de confianza del 95 % (IC 95 %) se calcularon a partir del coeficiente de análisis de regresión β1 y el error estándar (SE). Los valores de p < 0,05 se consideraron estadísticamente significativos. Resultados: De los datos analizados, 3363 (26,1%) fueron positivos para E. coli resistente a la ciprofloxacina. El aumento de E. coli resistente a la ciprofloxacina fue del 45,3 %. Las mujeres sufrieron más infección por E. coli sensible a la ciprofloxacina (75,5 %), pero los hombres tuvieron una mayor probabilidad de infectarse con E. coli resistente a la ciprofloxacina [2,132 (1,891-2,402)]. El aumento de la resistencia fue mayor para la nitrofurantoína (<0,001) y la ceftriaxona (<0,001). La prevalencia de resistencia fue alta para nitrofurantoína, norfloxacina, ácido nalidíxico, amoxicilina/clavulanato, ceftriaxona y tobramicina. A excepción de la gentamicina, que presentó una tendencia a la baja en la resistencia, los otros antimicrobianos analizados no mostraron tendencias en la resistencia a los antibióticos. Conclusiones: Hubo un aumento promedio en la resistencia a los principales antibióticos utilizados para tratar la infecciones del tracto urinario adquirida en la comunidad. Entre los antibióticos probados, solo la gentamicina mostró una tendencia a la baja en la resistencia. Estos resultados son importantes para dirigir la elección de los antimicrobianos para el tratamiento empírico de la infección urinaria adquirida en la comunidad.

ABSTRACT Introduction: Urinary tract infections caused by antibiotic-resistant Gram-negative bacteria are a growing concern due to limited therapeutic options. Objective: To analyze the antibiotic resistance trend in ciprofloxacin-resistant Escherichia coli isolated from community-acquired urinary tract infection. Methods: Time series study analyzing records of urine cultures positive for ciprofloxacin-resistant E. coli in persons aged ≥18 years from 2011 to 2017. The trends in antibiotic resistance patterns were obtained using the Prais-Winsten generalized linear regression. Annual percent change (APC) and 95% confidence interval (CI 95%) were calculated from the regression analysis coefficient β1 and standard error (SE). Values of p<0.05 were considered statistically significant. Results: From the analyzed data, 3 363 (26.1%) were positive for ciprofloxacin-resistant E. coli. The increase in ciprofloxacin-resistant E. coli was 45.3%. Females suffered more infection by ciprofloxacin-sensitive E. coli (75.5%), but males had a higher chance of being infected with ciprofloxacin-resistant E. coli. [2.132 (1.891- 2.402)]. Increase in resistance was highest for nitrofurantoin (<0.001) and ceftriaxone (<0.001). Prevalence of resistance was high for nitrofurantoin, norfloxacin, nalidixic acid, amoxicillin/clavulanate, ceftriaxone, and tobramycin. Except for gentamicin, which presented a downward trend in resistance, the other antimicrobials analyzed displayed no trends in antibiotic resistance. Conclusions: There was an average increase in resistance to the main antibiotics used to treat community-acquired UTI. Among the antibiotics tested, only gentamicin displayed a downward trend in resistance. These results are important to direct the choice of antimicrobials for the empirical treatment of community-acquired UTI.

An inventory of glacial lakes in the South Shetland Islands (Antarctica): temporal variation and environmental patterns
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PETSCH, CARINA

; ROSA, KÁTIA K. DA

; OLIVEIRA, MANOELA A.G. DE

; VELHO, LUIZ F.

; SILVA, SABRINA L.C.

; SOTILLE, MARIA E.

; VIEIRA, ROSEMARY

; SIMÕES, JEFFERSON C.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Supl. 1 elocation e20210683

Resumo: En | Texto: En | PDF: En

Abstract Monitoring and inventorying proglacial lakes in the Maritime Antarctica region is essential for understanding the effects of climate change on these environments. This study uses Landsat images to create a map of lakes in ice-free areas of the South Shetlands Islands (SSI) for 1986/89, 2000/03 and 2020, and verification of patterns of change in lake areas and numbers. Normalized water difference index (NDWI) products, image segmentation, field records, and cartographic products from other studies were used to validate the results. Results show a 60% increase in the number of lakes from 1986/89 to 2000/03; and a 55% increase from 2000/03 to 2020. There was a 52% increase in lake areas from 1986/89 to 2000/03; a 79% increase from 2000/03 to 2020; and a 173% increase from 1986 to 2020. From 1986 to 2020, the most significant changes were a decrease in the average elevation and distance from glaciers and an increase in distance from the sea. In 2020, SSI lakes were predominantly coastal and ice-marginal, with an E and S orientations, flat surfaces, and a low declivity.

https://doi.org/10.1590/0001-37652022020210683

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings
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ROSSATO, Tharsis Christini de Almeida

; ALVES, Tomaz

; CUEVAS-SUÁREZ, Carlos Enrique

; ROSA, Wellington Luiz de Oliveira da

; SILVA, Adriana Fernandes da

; PIVA, Evandro

; ZANCHi, Cesar Henrique

; LUND, Rafael Guerra

Brazilian Oral Research

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2022, Volume 36 elocation e091

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to formulate an experimental light-cured periodontal dressing containing alpha-humulene and to compare its physical, antimicrobial, and cytotoxicity properties with commercial gold standards (Barricaid® and Periobond®). Two periodontal dressing formulations were developed (a and b). The formulations were divided into 5 groups according to the alpha-humulene concentration as follows: Ea - control group, Ea1 - 1%, Ea5 - 5%, Ea10 - 10%, and Ea20 - 20%; Eb - control group, Eb1 - 1%, Eb5 - 5%, Eb10 - 10%, and Eb20 - 20%. Materials characterization was performed using the degree of conversion, cohesive strength, sorption, and solubility assays. Antimicrobial assay was performed using the modified direct contact test against E. faecalis and S. aureus. Cytotoxicity was assessed by the cell viability experiment using L929 fibroblasts. In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea1, Eb, and Eb1 groups showed moderate cytotoxic effect. The formulations containing alpha-humulene showed similar behavior to the commercial references. Thus, formulations containing alpha-humulene have potential to be used as periodontal dressing.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0091

Molecular detection of omicron SARS-CoV-2 variant is achieved by RT-LAMP despite genomic mutations
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Almeida, Letícia Trindade

; Gonçalves, Amanda Bonoto

; Franco-Luiz, Ana Paula Moreira

; Silva, Thais Bárbara de Souza

; Alves, Pedro Augusto

; Monte-Neto, Rubens Lima do

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220050

Resumo: En | Texto: En | PDF: En

BACKGROUND Severe acute respiratory syndrome coronavirus (SARS-CoV-2) omicron variant was first detected in South Africa in November 2021. Since then, the number of cases due to this variant increases enormously every day in different parts of the world. Mutations within omicron genome may impair the molecular detection resulting in false negative results during Coronavirus disease 19 (COVID-19) diagnosis. OBJECTIVES To verify if colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting N and E genes would work efficiently to detect omicron SARS-CoV-2 variant and its sub-lineages. METHODS SARS-CoV-2 reverse transcription quantitative polymerase chain reaction (RT-qPCR) positive samples were sequenced by next generation DNA sequencing. The consensus sequences generated were submitted to Pangolin tool for SARS-CoV-2 lineage identification. RT-LAMP reactions were performed at 65ºC/30 min targeting N and E. FINDINGS SARS-CoV-2 omicron can be detected by RT-LAMP targeting N and E genes despite the genomic mutation of this more transmissible lineage. Omicron SARS-CoV-2 sub-lineages were tested and efficiently detected by RT-LAMP. We demonstrated that this test is very sensitive in detecting omicron variant, with LoD as low as 0.4 copies/µL. MAIN CONCLUSIONS Molecular detection of omicron SARS-CoV-2 variant and its sub-lineages can be achieved by RT-LAMP despite the genomic mutations as a very sensitive surveillance tool for COVID-19 molecular diagnosis.

https://doi.org/10.1590/0074-02760220050

Pathological changes by spirorchiid eggs in hawksbill sea turtle (Eretmochelys imbricata) stranded off brazilian coast
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SILVA, MARIA APARECIDA DA

; MEDINA, RAPHAEL M.

; LEANDRO, HASSAN J.

; RIBEIRO, RACHEL B.

; PETRONILHA, MARIAH B.R.G.

; CARVALHO, EULÓGIO CARLOS Q. DE

; SILVEIRA, RENATO LUIZ

; WERNECK, MAX R.

; SHIMODA, EDUARDO

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Nº 4 elocation e20201107

Resumo: En | Texto: En | PDF: En

Abstract Eretmochelys imbricata (hawksbill turtle) is classified as a critically endangered species at world level; in Brazil, it is listed among the threatened species. Spirorchiids are parasites of the circulatory system of chelonians which may cause serious lesions in the various tissues of the host due to deposition of eggs in the bloodstream. In this context, the aim of the present study was to describe the pathology caused by spirorchiid eggs in E. imbricata from the Brazilian over a five year period. A total of 29 animals were analyzed, of which nine (31%) presented lesions associated to spirorchiids eggs. The lesions were: granulomatous enteritis in six (66.66%), granulomatous splenitis in five (55.55%), granulomatous hepatitis in three (33.33%), granulomatous pneumonia in three (33.33%), granulomatous pancreatitis in two (22.22%), and granulomatous adrenalitis in one specimen (11.11%). Concluded the main lesion in Eretmochelys imbricata was giant-cell granulomatous inflammatory reaction to the parasite’s eggs. Animals exhibiting poor physical health were more susceptible to presenting such lesions.

https://doi.org/10.1590/0001-3765202220201107

10.

Evaluation of temporary cement to prevent bacterial contamination of the root canal after pulpectomy
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PEREIRA, Letícia Martins

; NAVES, Sophia Maria Mateus

; COSTA, Júlia Modesto da

; MORAES, Igor de Oliveira

; SILVA, Sandra Regina Echeverria Pinho da

; FONTANA, Carlos Eduardo

; PINHEIRO, Sérgio Luiz

RGO - Revista Gaúcha de Odontologia

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2022, Volume 70 elocation e20220035

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Avaliar a capacidade do obturador provisório (OP) e da gutapercha em bastão (GP) de prevenir a contaminação bacteriana dos condutos radiculares. Foram selecionados 80 incisivos centrais superiores decíduos artificiais que foram divididos aleatoriamente em 2 grupos: OP (n = 40) e GP (n = 40). Foi realizado acesso endodôntico, instrumentação rotatória, preenchimento do canal radicular e selamento coronário conforme os grupos. Foi feita a semeadura de S.mutans e E. faecalis na entrada do canal radicular. Ambos os grupos foram subdivididos em 5 tempos experimentais (24, 48, 72, 96 e 120 horas), com 8 espécimes por tempo experimental: 5 submetidos a preenchimento do canal radicular e selamento coronário (com OP ou GP) e 3 controles (apenas selamento coronário, sem preenchimento do canal). Todos os espécimes foram incubados em jarras de anaerobiose a 37°C e a contaminação bacteriana foi avaliada em espectrofotômetro. Utilizou-se ANOVA (teste t) para a comparação da contaminação e o teste de Kruskal-Wallis para a comparação dos escores da obturação entre os grupos experimentais. Foi observada diferença significativa no selamento nas primeiras 24 horas entre GP e controles (p = 0,046). Não houve diferença estatisticamente significativa no padrão de preenchimento entre os canais selados com OP versus GP. Os espécimes selados com GP apresentaram menor contaminação do que os controles nas primeiras 24 horas. Nos demais tempos experimentais, tanto GP quanto OP não foram eficientes no controle da contaminação bacteriana; ambos apresentaram falha no selamento coronário.

ABSTRACT To evaluate the ability of temporary cement (TC) and gutta-percha sticks (GP) to prevent bacterial contamination of the root canal through the coronal seal after pulpectomy. Eighty artificial primary maxillary central incisors were selected and randomly divided into 2 groups: TC (n = 40) and GP (n = 40). Endodontic access, rotary instrumentation, root canal filling, and coronal sealing were performed according to group allocation. The root canal opening was seeded with S. mutans and E. faecalis. Both groups were subdivided into 5 experimental time points (24, 48, 72, 96, and 120 hours), with 8 specimens per time-point group: 5 in which both root canal filling and coronal sealing were performed (with either TC or GP) and 3 controls (coronal sealing alone, without root canal filling). All specimens were incubated in an anaerobic jar at 37°C, and bacterial contamination was assessed in a spectrophotometer. ANOVA (t-test) was used to compare contamination and the Kruskal-Wallis test to compare filling scores between the experimental groups. A significant difference was observed in sealing in the first 24 hours between GP and controls (p = 0.046). There was no significant difference in the filling pattern between canals sealed with TC versus GP. Specimens sealed with GP showed less contamination than controls in the first 24 hours. At later time points, neither GP nor TC were effective at controlling bacterial contamination; both failed to provide adequate coronal sealing.

https://doi.org/10.1590/1981-86372022003520210014

11.

Intra-annual colonization of Chironomidae on leaf litter in a Brazilian Cerrado stream
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Pio, Jéssica F.G.

; Hepp, Luiz U.

; Medeiros, Adriana O.

; Silva, Fabio L. da

; Copatti, Carlos E.

Zoologia (Curitiba)

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2022, Volume 39 elocation e22015

Resumo: En | Texto: En | PDF: En

ABSTRACT In low-order streams, the processing of allochthonous leaf litter is essential in the carbon/energy flow dynamics. Benthic macroinvertebrates, such as chironomids, play critical roles in the breakdown of allochthonous materials, because their larvae take part in intricate trophic networks and have varied trophic ecologies. We evaluated the effects of intra-annual variability on the input of allochthonous leaf litter, and the interactions of leaf-detritus on the succession of Chironomidae assemblages in the dry, rainy, and transition seasons (rainy-dry and dry-rainy). The study took place in a stream in the Brazilian Cerrado. Leaves were incubated in the stream to ascertain the colonization process by Chironomidae and the loss of leaf litter mass after 90 days. Functional feeding groups (FFG) were less rich and less abundant in the dry and dry-rainy seasons, than in the other seasons. The FFG composition of Chironomidae demonstrated that temporal variation between seasons was affected by the exposure time of the leaf-detritus in the stream, and there was more segregation during the dry and rainy seasons. In conclusion, the colonization of leaf-detritus by Chironomidae larvae depended on how long allochthonous plant material remained in the stream, and the variability of the organic matter dynamics input into the stream.

https://doi.org/10.1590/s1984-4689.v39.e22015

12.

The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA

; BACCARO, FABRICIO

; CRONEMBERGER, CECILIA

; HIPÓLITO, JULIANA

; BARROS, CLAUDIA FRANCA

; RODRIGUES, DOMINGOS DE JESUS

; NECKEL-OLIVEIRA, SELVINO

; OVERBECK, GERHARD E.

; DRECHSLER-SANTOS, ELISANDRO RICARDO

; ANJOS, MARCELO RODRIGUES DOS

; FERREGUETTI, ÁTILLA C.

; AKAMA, ALBERTO

; MARTINS, MARLÚCIA BONIFÁCIO

; TOMAS, WALFRIDO MORAES

; SANTOS, SANDRA APARECIDA

; FERREIRA, VANDA LÚCIA

; CUNHA, CATIA NUNES DA

; PENHA, JERRY

; PINHO, JOÃO BATISTA DE

; SALIS, SUZANA MARIA

; DORIA, CAROLINA RODRIGUES DA COSTA

; PILLAR, VALÉRIO D.

; PODGAISKI, LUCIANA R.

; MENIN, MARCELO

; BÍGIO, NARCÍSIO COSTA

; ARAGÓN, SUSAN

; MANZATTO, ANGELO GILBERTO

; VÉLEZ-MARTIN, EDUARDO

; SILVA, ANA CAROLINA BORGES LINS E

; IZZO, THIAGO JUNQUEIRA

; MORTATI, AMANDA FREDERICO

; GIACOMIN, LEANDRO LACERDA

; ALMEIDA, THAÍS ELIAS

; ANDRÉ, THIAGO

; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA

; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA

; MESSIAS, MARILUCE REZENDE

; MARQUES, MARCIA C.M.

; PADIAL, ANDRE ANDRIAN

; MARQUES, RENATO

; BITAR, YOUSZEF O.C.

; SILVEIRA, MARCOS

; MORATO, ELDER FERREIRA

; PAGOTTO, RUBIANI DE CÁSSIA

; STRUSSMANN, CHRISTINE

; MACHADO, RICARDO BOMFIM

; AGUIAR, LUDMILLA MOURA DE SOUZA

; FERNANDES, GERALDO WILSON

; OKI, YUMI

; NOVAIS, SAMUEL

; FERREIRA, GUILHERME BRAGA

; BARBOSA, FLÁVIA RODRIGUES

; OCHOA, ANA C.

; MANGIONE, ANTONIO M.

; GATICA, AILIN

; CARRIZO, MARÍA CELINA

; RETTA, LUCÍA MARTINEZ

; JOFRÉ, LAURA E.

; CASTILLO, LUCIANA L.

; NEME, ANDREA M.

; RUEDA, CARLA

; TOLEDO, JOSÉ JULIO DE

; GRELLE, CARLOS EDUARDO VIVEIROS

; VALE, MARIANA M.

; VIEIRA, MARCUS VINICIUS

; CERQUEIRA, RUI

; HIGASHIKAWA, EMÍLIO MANABU

; MENDONÇA, FERNANDO PEREIRA DE

; GUERREIRO, QUÊZIA LEANDRO DE MOURA

; BANHOS, AUREO

; HERO, JEAN-MARC

; KOBLITZ, RODRIGO

; COLLEVATTI, ROSANE GARCIA

; SILVEIRA, LUÍS FÁBIO

; VASCONCELOS, HERALDO L.

; VIEIRA, CECÍLIA RODRIGUES

; COLLI, GUARINO RINALDI

; CECHIN, SONIA ZANINI

; SANTOS, TIAGO GOMES DOS

; FONTANA, CARLA S.

; JARENKOW, JOÃO A.

; MALABARBA, LUIZ R.

; RUEDA, MARTA P.

; ARAUJO, PUBLIO A.

; PALOMO, LUCAS

; ITURRE, MARTA C.

; BERGALLO, HELENA GODOY

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 2 elocation e20201604

Resumo: En | Texto: En | PDF: En

Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.

https://doi.org/10.1590/0001-3765202120201604 1034 downloads

13.

BRAZILIAN GASTRIC CANCER ASSOCIATION GUIDELINES (PART 2): UPDATE ON TREATMENT
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BARCHI, Leandro Cardoso

; RAMOS, Marcus Fernando Kodama Pertille

; DIAS, André Roncon

; FORONES, Nora Manoukian

; CARVALHO, Marineide Prudêncio de

; CASTRO, Osvaldo Antonio Prado

; KASSAB, Paulo

; COSTA-JÚNIOR, Wilson Luiz da

; WESTON, Antônio Carlos

; ZILBERSTEIN, Bruno

; Ferraz, Álvaro Antônio Bandeira

; ZeideCharruf, Amir

; Brandalise, André

; Silva, André Maciel da

; Alves, Barlon

; Marins, Carlos Augusto Martinez

; Malheiros, Carlos Alberto

; Leite, Celso Vieira

; Bresciani, Claudio José Caldas

; Szor, Daniel

; Mucerino, Donato Roberto

; Wohnrath, Durval R.

; JirjossIlias, Elias

; Martins Filho, Euclides Dias

; PinatelLopasso, Fabio

; Coimbra, Felipe José Fernandez

; Felippe, Fernando E. Cruz

; Tomasisch, Flávio Daniel Saavedra

; Takeda, Flavio Roberto

; Ishak, Geraldo

; Laporte, Gustavo Andreazza

; Silva, Herbeth José Toledo

; Cecconello, Ivan

; Rodrigues, Joaquim José Gama

; Grande, José Carlos Del

; Lourenço, Laércio Gomes

; Motta, Leonardo Milhomem da

; Ferraz, Leonardo Rocha

; Moreira, Luis Fernando

; Lopes, Luis Roberto

; Toneto, Marcelo Garcia

; Mester, Marcelo

; Rodrigues, Marco Antônio Gonçalves

; Franciss, Maurice Youssef

; AdamiAndreollo, Nelson

; Corletta, Oly Campos

; Yagi, Osmar Kenji

; Malafaia, Osvaldo

; Assumpção, Paulo Pimentel

; Savassi-Rocha, Paulo Roberto

; Colleoni Neto, Ramiro

; Oliveira, Rodrigo Jose de

; AissarSallun, Rubens Antonio

; Weschenfelder, Rui

; Oliveira, Saint Clair Vieira de

; Abreu, Thiago Boechat de

; Castria, Tiago Biachi de

; Ribeiro Junior, Ulysses

; Barra, Williams

; Freitas Júnior, Wilson Rodrigues de

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2021, Volume 34 Nº 1 elocation e1563

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Racional: O II Consenso Brasileiro de Câncer Gástrico da Associação Brasileira de Câncer Gástrico ABCG (Parte 1) foi recentemente publicado. Nesta ocasião inúmeros especialistas que atuam no tratamento desta doença expressaram suas opiniões diante declarações apresentadas. Objetivo: Apresentar as Diretrizes da ABCG (Parte 2) quanto às indicações de tratamento cirúrgico, técnicas operatórias, extensão de ressecção e terapia combinada. Métodos: Para formulação destas diretrizes os autores realizaram extensa e atual revisão referente a cada declaração presente no II Consenso, utilizando as bases Medline/PubMed, Cochrane Library e SciELO, inicialmente com os seguintes descritores: câncer gástrico, gastrectomia, linfadenectomia, terapia combinada. Ainda, cada declaração foi classificada de acordo com o nível de evidência e grau de recomendação. Resultados: Das 43 declarações presentes neste estudo, 11 (25,6%) foram classificadas com nível de evidência A, 20 (46,5%) B e 12 (27,9%) C. Quanto ao grau de recomendação, 18 (41,9%) declarações obtiveram grau de recomendação 1, 14 (32,6%) 2a, 10 (23,3%) 2b e um (2,3%) 3. Conclusão: O complemento das diretrizes aqui presentes possibilita que cirurgiões e oncologistas que atuam no combate ao câncer gástrico possam oferecer o melhor tratamento possível, de acordo com as condições locais disponíveis.

ABSTRACT Background : The II Brazilian Consensus on Gastric Cancer of the Brazilian Gastric Cancer Association BGCA (Part 1) was recently published. On this occasion, countless specialists working in the treatment of this disease expressed their opinion in the face of the statements presented. Aim : To present the BGCA Guidelines (Part 2) regarding indications for surgical treatment, operative techniques, extension of resection and multimodal treatment. Methods: To formulate these guidelines, the authors carried out an extensive and current review regarding each declaration present in the II Consensus, using the Medline/PubMed, Cochrane Library and SciELO databases initially with the following descriptors: gastric cancer, gastrectomy, lymphadenectomy, multimodal treatment. In addition, each statement was classified according to the level of evidence and degree of recommendation. Results : Of the 43 statements present in this study, 11 (25,6%) were classified with level of evidence A, 20 (46,5%) B and 12 (27,9%) C. Regarding the degree of recommendation, 18 (41,9%) statements obtained grade of recommendation 1, 14 (32,6%) 2a, 10 (23,3%) 2b e one (2,3%) 3. Conclusion : The guidelines complement of the guidelines presented here allows surgeons and oncologists who work to combat gastric cancer to offer the best possible treatment, according to the local conditions available.

https://doi.org/10.1590/0102-672020210001e1563 768 downloads

14.

Advanced Microtexture Evaluation of Dextran Biofilms Obtained from Low Cost Substrate Loaded with Maytenus rigida Extract
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Silva, Mário R. P.

; Matos, Robert S.

; Pinto, Erveton P.

; Santos, Samuel B.

; Monteiro, Michael D. S.

; Fonseca Filho, Henrique D. da

; Almeida, Luiz E.

Materials Research

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2021, Volume 24 Nº 4 elocation e20200597

Resumo: En | Texto: En | PDF: En

Abstract We have obtained kefir biofilms loaded with Maytenus rigida extract. The main goal was to evaluate the influence of the addition of the extract on the biofilms microtexture using stereometric and fractal parameters. Atomic force microscopy, Fourier transform infrared spectroscopy, and contact angle tecniques were used to evaluate the topography, chemical interation and wettability of the biofilms. Chemical evaluation showed that the extract interacts with the polymeric matrix of the biofilms, changing their structure. This behavior affected the surface energy because the wettability decreased when the Maytenus content increased. The surface morphology was also affected and suggested the prevalence of bacteria and yeast at lower and higher extract concentrations, respectively. The surface roughness increased according to the increase in the extract concentration. Texture parameters revealed that the biofilm with lowest concentration had deeper furrows than for higher concentration. Advanced fractal parameters revealed that topographic uniformity, percolation and texture homogeneity were more suitable for the biofilm with 0.25 g.L-1 of extract. These results indicate that this biofilm have promising 3D micromorphology for regenerative medicine application. Furthermore, the physics tools used revealed to be very useful for characterizing of the microtexture of polymeric-based biological materials.

https://doi.org/10.1590/1980-5373-mr-2020-0597 122 downloads

15.

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Resumo: En | Texto: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

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