ABSTRACT The Hepatitis C virus (HCV) infection is a public health problem. The high level of HCV replication and its lack of post-transcriptional correction mechanisms results in the emergence of viral variants and the difficulty in determining polymorphisms and variants that contain the substitutions associated with resistance towards new antivirals. The main focus of this study was to map the NS5A and NS5B polymorphisms and resistance mutations to new antiviral drugs in HCV strains genotype 1 from patients with chronic hepatitis C infection. Serum samples were collected from patients who underwent routine viral load tests at the Instituto Adolfo Lutz, Sao Paulo city, Brazil. A total of 698 and 853 samples were used for the characterization of NS5A and NS5B regions, respectively, which comprise the HCV genotypes 1a and 1b. The prevalence of resistance mutations found in the NS5A region was 6.4%, with Y93H, L31M, Q30R, and Y93N as the main resistance-associated substitutions (RAS). No NS5B-associated RAS was observed for any of the analyzed drugs. These findings support that the RAS test should be offered to individuals with poor response to double combination regimens prior to treatment initiation, thereby assisting strain vigilance and selection of effective treatment or retreatment options using DAA regimens.

Resumo Objetivo refletir sobre a COVID-19 como um fenômeno de representações sociais para a equipe de enfermagem da Unidade de Terapia Intensiva, analisando as implicações dessa compreensão teórica no delineamento das práticas sociais de tais profissionais. Método estudo teórico-reflexivo, pautado no referencial das representações sociais. Captaram-se artigos científicos, livros e dados oficiais sobre a COVID-19; posteriormente, procedeu-se o aprofundamento reflexivo com base nos preceitos da teoria. Desenvolvimento a COVID-19 vem apresentando um forte impacto no cuidado de enfermagem na terapia intensiva. O atendimento dos critérios das representações sociais: da relevância, da prática, do consenso e da afiliação; as dimensões dos afetos, imagética e das práticas sociais mobilizadas na construção social desse fenômeno; e as características do cotidiano da pertença social da equipe de enfermagem atuante na terapia intensiva diante dos pacientes com a COVID-19 foram os argumentos teóricos que sustentaram a defesa de que a COVID-19 é um fenômeno de representação social para esse grupo social. Conclusão e implicações para a prática estudos das representações sociais desses profissionais sobre a COVID-19 podem subsidiar a proposição de tecnologias de cuidado-educação que qualifiquem a sua atuação no atendimento aos pacientes críticos com a COVID-19.

Abstract Objective to reflect on COVID-19 as a phenomenon of social representations for the Intensive Care Unit nursing team, analyzing the implications of this theoretical understanding in the design of professionals’ social practices. Method this is a theoretical-reflective study, based on the framework of social representations. Scientific articles, books and official data on COVID-19 were collected; subsequently, reflective deepening was carried out based on the theory precepts. Development COVID-19 has had a strong impact on nursing care in intensive care. Meeting the criteria of social representations: relevance, practice, consensus and affiliation; the dimensions of affections, imagery and social practices mobilized in the social construction of this phenomenon; characteristics of daily life of social belonging of nursing teams working in intensive care before patients with COVID-19 were theoretical arguments that supported the defense that COVID-19 is a phenomenon of social representation for this social group. Conclusion and implications for practice studies of professionals’ social representations about COVID-19 can support the proposition of care-education technologies that qualify their performance in caring for critical patients with COVID-19.

Resumen Objetivo Reflexionar sobre la COVID-19 como fenómeno de representaciones sociales para el equipo de enfermería de la Unidad de Cuidados Intensivos, con el análisis de las implicaciones de esta comprensión teórica en las prácticas sociales de dichos profesionales. Método Estudio teórico-reflexivo, basado en el marco de las representaciones sociales. Se capturaron artículos científicos, libros y datos oficiales sobre la COVID-19; posteriormente, se procedió a una profundización reflexiva basada en los preceptos de la teoría. Desarrollo la COVID-19 ha tenido un fuerte impacto en la atención de enfermería en cuidados intensivos. Cumplir con los criterios de las representaciones sociales: relevancia, práctica, consenso y afiliación; las dimensiones de los afectos, de las imágenes y de las prácticas sociales movilizadas en la construcción social de este fenómeno; y las características cotidianas de la pertenencia social del equipo de enfermería que trabaja en cuidados intensivos ante pacientes con COVID-19 fueron los argumentos teóricos que sustentaron la defensa de que la COVID-19 es un fenómeno de representación social para este grupo social. Conclusión e implicaciones para la práctica Los estudios de las representaciones sociales de estos profesionales sobre la COVID-19 pueden apoyar la propuesta de tecnologías de cuidado-educación que califiquen su desempeño en el cuidado de pacientes críticos con COVID-19.

ABSTRACT OBJECTIVE To investigate the HCV cascade of care and to identify the factors associated with loss or absence to follow-up of patients identified as infected with hepatitis C through blood donation. METHODS Blood donors from 1994 to 2012, identified with positive anti- HCV by enzyme immunoassay and immunoblot tests were invited to participate in the study, through letters or phone calls. Patients who agreed to participate were interviewed and their blood samples were collected for further testing. The following variables were investigated: demographic data, data on comorbidities and history concerning monitoring of hepatitis C. Multiple regression analysis by Poisson regression model was used to investigate the factors associated with non-referral for consultation or loss of follow-up. RESULTS Of the 2,952 HCV-infected blood donors, 22.8% agreed to participate: 394 (58.2%) male, median age 48 years old and 364 (53.8%) Caucasian. Of the 676 participants, 39.7% did not receive proper follow-up or treatment after diagnosis: 45 patients referred not to be aware they were infected, 61 did not seek medical attention and 163 started a follow-up program, but were non-adherent. The main reasons for inadequate follow-up were not understanding the need for medical care (71%) and health care access difficulties (14%). The variables showing a significant association with inadequate follow-up after multiple regression analysis were male gender (PR = 1.40; 95%CI 1.15–1.71), age under or equal to 50 years (PR = 1.36; 95%CI 1.12–1.65) and non-Caucasians (PR = 1.53; 95%CI 1.27–1.84). CONCLUSIONS About 40.0% of patients did not receive appropriate follow-up. These data reinforce the need to establish strong links between primary care and reference centers and the need to improve access to specialists and treatments.

ABSTRACT OBJECTIVE To investigate the HCV cascade of care and to identify the factors associated with loss or absence to follow-up of patients identified as infected with hepatitis C through blood donation. METHODS Blood donors from 1994 to 2012, identified with positive anti- HCV by enzyme immunoassay and immunoblot tests were invited to participate in the study, through letters or phone calls. Patients who agreed to participate were interviewed and their blood samples were collected for further testing. The following variables were investigated: demographic data, data on comorbidities and history concerning monitoring of hepatitis C. Multiple regression analysis by Poisson regression model was used to investigate the factors associated with non-referral for consultation or loss of follow-up. RESULTS Of the 2,952 HCV-infected blood donors, 22.8% agreed to participate: 394 (58.2%) male, median age 48 years old and 364 (53.8%) Caucasian. Of the 676 participants, 39.7% did not receive proper follow-up or treatment after diagnosis: 45 patients referred not to be aware they were infected, 61 did not seek medical attention and 163 started a follow-up program, but were non-adherent. The main reasons for inadequate follow-up were not understanding the need for medical care (71%) and health care access difficulties (14%). The variables showing a significant association with inadequate follow-up after multiple regression analysis were male gender (PR = 1.40; 95%CI 1.15–1.71), age under or equal to 50 years (PR = 1.36; 95%CI 1.12–1.65) and non-Caucasians (PR = 1.53; 95%CI 1.27–1.84). CONCLUSIONS About 40.0% of patients did not receive appropriate follow-up. These data reinforce the need to establish strong links between primary care and reference centers and the need to improve access to specialists and treatments.

Ignácio Rangel é autor de imensa originalidade; no entanto, seu trabalho vem sendo pouco explorado na história do pensamento econômico brasileiro. O objetivo deste trabalho é desenvolver um movimento que recupere a interpretação rangeliana do Brasil, destacando sua concepção da dualidade básica para reapresentar Rangel à lista dos grandes intérpretes brasileiros.

Ignacio Rangel is an author of immense originality, although his work has been little explored in the Brazilian history of economic thought. The objective of this work is to develop a movement to recover the Rangelian interpretation of Brazil, putting light on his conception of basic duality and reintroducing Rangel in the list of the great interpreters of Brazil.

Este trabalho busca apresentar as principais questões trazidas pela obra de James Steuart ao pensamento heterodoxo atual. Os trabalhos de Steuart sobre economia política possuem a marca da dualidade. Tal dualidade em seu pensamento o condenou ao ocaso em sua época e à vala comum do mercantilismo por parte da história do pensamento econômico tradicional, mas também foi a riqueza de sua obra. Este artigo procura explorar essa característica dual da obra de Steuart para conectá-la com as releituras e reabilitações de seu pensamento promovidas pela heterodoxia atual. Este estudo se insere, portanto, no movimento que busca ampliar o conhecimento da visão de Steuart sobre o funcionamento da economia e sobre a economia como ciência, para evidenciar que essa disciplina, desde a sua concepção como ciência autônoma, já dispunha de alternativas embebidas nas importantes divergências metodológicas referentes aos modos de pensar a natureza das ciências sociais.

This work intends to present the main heterodox questions brought up by James Steuart´s thought. Steuart´s works on political economy have the sign of duality. This sign condemned this work to ostracism during this life time and labeled him as mercanlist in the history of economic thought. This article uses the duality in his work to connect it with the recent research recovering his initial ideas. This study is a part of a movement that seeks to spread the knowledge of Steuart´s visions about the economic process and political economy as a science to put forward the interpretation that political economy in its origin is submerged in important divergences about scientific perspectives.