Pesquisa | SciELO

Resumen Objetivo: Describir la evolución de las cadenas livianas libres séricas (CLL) en el período comprendido entre el trasplante cardíaco ortotópico (TCO) y el trasplante de células progenitoras hematopoyéticas (TCPH), la respuesta hematológica al año tras el TCPH y el tratamiento quimioterápico e inmunosupresor en pacientes con amiloidosis AL. Método: Serie de casos de pacientes consecutivos con diagnóstico de amiloidosis AL que recibieron TCO seguido de TCPH del Registro Institucional de Amiloidosis del Hospital Italiano de Buenos Aires, entre enero de 2010 y noviembre de 2021. Se reportaron los valores de CLL entre trasplantes y al año del TCPH. Las variables cuantitativas se describieron como mediana e intervalo intercuartil, y las variables categóricas como frecuencias absolutas y relativas. Resultados: De 106 pacientes con amiloidosis AL, seis tuvieron TCO seguido de TCPH. La mediana de edad fue de 55 años. La mayoría eran hombres (n = 5). En el período entre trasplantes, la CLL involucrada disminuyó en dos pacientes y se mantuvo estable en tres. Todos lograron la remisión hematológica completa al año del TCPH. Un solo paciente presentó recaída en el órgano sólido trasplantado. Tacrolimus, micofenolato de mofetilo y corticoides fue el esquema inmunosupresor utilizado después del TCO. Conclusiones: El TCO representa una opción de tratamiento en pacientes con falla cardíaca grave por amiloidosis, permitiendo luego un tratamiento intensivo con quimioterapia de inducción y TCPH. Si bien faltan estudios, la terapia inmunosupresora después del TCO podría tener algún efecto sobre las células plasmáticas clonales.

Abstract Objective: To describe the evolution of serum free light chains (FLC) in the period between orthotopic heart transplantation (OHT) and autologous stem cell transplantation (ASCT), the hematological response one year after ASCT and chemotherapy and immunosuppressive treatment in patients with AL amyloidosis. Method: Case series of consecutive patients diagnosed with AL amyloidosis who received OHT followed by ASCT from the Institutional Registry of Amyloidosis of the Italian Hospital of Buenos Aires, between January 2010 and November 2021. FLC values between transplants and at year post ASCT. Quantitative variables were described with their median and interquartile range. Categorical variables as absolute and relative frequencies. Results: Of 106 patients with AL amyloidosis, 6 had an OHT followed by ASCT. The median age was 55 years. Most were men (n = 5). In the period between transplants, the involved CLL decreased in two patients and remained stable in three. All achieved complete hematologic remission 1 year after ASCT. A single patient presented relapse in the transplanted solid organ. Tacrolimus, mycophenolate mofetil, and corticosteroids were the immunosuppressive regimen used after OHT. Conclusions: OHT represents a treatment option in patients with severe heart failure due to amyloidosis, allowing later intensive treatment with induction chemotherapy and ASCT. Although studies are lacking, immunosuppressive therapy after OHT might have some effect on clonal plasma cells.

https://doi.org/10.24875/acm.22000208

Insuficiencia cardiaca secundaria a amiloidosis AL: diagnóstico y tratamiento
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Lloveras, Eugenia Pérez

; Decotto, Santiago

; Villanueva, Eugenia

; Marco, María Agustina

; Carretero, Marcelina

; Posadas-Martinez, María Lourdes

; Pérez de Arenaza, Diego

; Nucifora, Elsa

; Aguirre, María Adela

Medicina (Buenos Aires)

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Dez 2023, Volume 83 Nº 5 Páginas 813 - 815

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Light chain amyloidosis (AL) is a rare and underdi agnosed disease. The best treatment available is au tologous bone marrow transplantation (BMT). Cardiac involvement is the main prognostic determinant in this pathology and sometimes an impediment to re ceive BMT. We present a clinical case of a 44-year-old who consulted for signs and symptoms of heart failure (HF) with elevated cardiac biomarkers. A transthoracic echocardiogram showed increased wall thickness with global hypokinesia and mildly impaired ejection fraction (50%). The patient was admitted to the coronary unit for treatment with diuretics and for etiological study of the condition. In view of the suspicion of infiltrative disease, a bone scintigraphy with pyrophosphate and free light chains in serum were requested. The bone scintigraphy was not suggestive of transthyretin amyloidosis and the free light chains showed a ratio of less than 0.26 with lambda predominance. A gum biopsy was per formed and confirmed the diagnosis of AL amyloidosis. After diagnosis, specific chemotherapy treatment with Cyclophosphamide, Bortezomib and Dexamethasone (CYBORD scheme) and Daratumumab was started. He evolved with refractory HF so it was decided to admit him to the cardiac transplantation list, receiving the same soon after, with good evolution. This allowed the patient to restart the chemotherapy regimen and finally receive BMT, with good evolution.

Resumen La amiloidosis por depósito de cadenas livianas de inmunoglobulinas (AL) es una enfermedad poco frecuen te y subdiagnosticada. El mejor tratamiento disponible al momento es el trasplante autólogo de médula ósea (TMO). El compromiso cardíaco es el principal determi nante pronóstico en esta patología y en ocasiones un impedimento para recibir el TMO. Se presenta el caso de un varón de 44 años que consultó por signos y síntomas de insuficiencia cardiaca (IC) con biomarcadores cardia cos elevados. Se realizó un ecocardiograma transtorácico donde se objetivó aumento de espesores parietales con hipoquinesia global y fracción de eyección deteriorada en grado leve (50%). El paciente se internó en unidad coronaria para balance negativo y para estudio etiológico del cuadro. Ante la sospecha de enfermedad infiltrativa, se solicitaron un centellograma óseo con pirofosfato y cadenas livianas libres en suero. El centellograma óseo resultó no sugestivo para amiloidosis por transtiretina y las cadenas livianas libres mostraron una relación me nor a 0.26 con predominio lambda. Se realizó una biopsia de encía que confirmó el diagnóstico de amiloidosis AL. Posterior al diagnóstico comenzó tratamiento qui mioterápico específico con Ciclofosfamida, Bortezomib y Dexametasona (esquema CYBORD) y Daratumumab. Evolucionó con IC refractaria por lo que ingresó a lista de trasplante cardiaco, recibiendo el mismo al poco tiempo con buena evolución. Esto permitió reiniciar el esquema quimioterápico y en segundo término finalmente recibir el TMO, con buena evolución.

Degradation dynamics of organophosphorus insecticides applied in stored soybean ( Glycine max L.) during supervised trials.
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Strada, Julieta

; Bruno, Cecilia

; Nassetta, Mirtha M.

; Balzarini, Mónica

; Conles, Martha

; Rojas, Dante

; Ricca, Alejandra P.

; Cristos, Diego

; Martinez, María José

Revista Facultad Nacional de Agronomía Medellín

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Abr 2023, Volume 76 Nº 1 Páginas 10167 - 10175

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Durante el almacenamiento, los granos de soja pueden ser atacados por insectos, que se controlan preventivamente con insecticidas. La información sobre la disipación de los residuos de insecticidas es crucial para conocer sus concentraciones finales en los alimentos y establecer los períodos de carencia necesarios para su consumo sin riesgos para la salud, así como para cumplir con las normas nacionales e internacionales. Los objetivos de este estudio fueron cuantificar los niveles de residuos de insecticidas organofosforados (diclorvos, clorpirifos-metilo y pirimifos-metilo) en soja almacenada, establecer el efecto de los días de almacenamiento y modelizar la dinámica de disipación. Los residuos de insecticidas en la soja se analizaron a los 2, 30, 60, 90 y 120 días después de la aplicación. Se validó un método analítico basado en la extracción por QuEChERS seguida de la determinación por cromatografía gaseosa acoplada a espectrometría de masas (GC-MS/MS), con recuperaciones medias del 82-105%, dependiendo de los niveles de adición. Los residuos disminuyeron por debajo del 80% de la concentración inicial a los 60 días de la aplicación y por debajo de los niveles cuantificables a los 120 días. Los residuos siguieron una dinámica de disipación de pseudoprimer orden [Ct = C0×exp(-k.t)], siendo la constante de disipación (k) y las vidas medias de 0,538 y 1,3 días para diclorvos, 0,018 y 38,8 días para clorpirifos-metilo, y 0,023 y 30,1 días para pirimifos-metilo, respectivamente. Estos resultados permiten concluir que, a la dosis recomendada, estos insecticidas son seguros para su uso en granos de soja almacenados.

ABSTRACT During storage, soybean kernels can be attacked by insects, which are preventively controlled with insecticides. Information on the dissipation of insecticide residues is crucial to know their final concentrations in food and establish the waiting periods necessary for consumption without health risks, and to determine the minimum waiting period necessary to comply with national and international standards. The aims of this study were to quantify the residue levels of organophosphorus insecticides (dichlorvos, chlorpyrifos-methyl and pirimiphos-methyl) in stored soybean, establish the effect during the storage period, and model the dissipation dynamics. Insecticide residues in soybeans were analyzed at 2, 30, 60, 90 and 120 days after application. An analytical method based on QuEChERS extraction followed by gas chromatography mass spectrometry (GC-MS/MS) determination was validated, with mean recoveries of 82-105%, depending on the spiking levels. Residues decreased below 80% of the initial concentration at 60 days after application and below quantifiable levels at 120 days. Residues followed a pseudo-first-order dissipation dynamics [Ct = C0×exp(-k.t)], with the dissipation constant (k) and half-lives being 0.538 and 1.3 days for dichlorvos, 0.018 and 38.8 days for chlorpyrifos-methyl, and 0.023 and 30.1 days for pirimiphos-methyl, respectively. These results allow concluding that, at the recommended dosage, these insecticides are safe for use on soybean grains stored under standard conditions commonly nowadays used in Argentina.

https://doi.org/10.15446/rfnam.v76n1.102472

Physicochemical Characterization, Quantitative Drug Analysis, and Stability Testing of Hydroxytyrosol-loaded Poly(ԑ-caprolactone) Nanocapsules
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Ribeiro, Juliana Parente Menezes

; Schebelski, Diego José

; Lyra, Amanda Martinez

; Camargo, Guilherme dos Anjos

; Nadal, Jessica Mendes

; Novatski, Andressa

; Manfron, Jane

; Farago, Paulo Vitor

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e23230081

Resumo: En | Texto: En | PDF: En

Abstract Hydroxytyrosol (HT) is a natural phenolic compound found in leaves of olive trees. It is a photosensitive solid phytochemical constituent and an irritant substance to skin and mucosa as pure drug. HT is a lipophilic chemical constituent and shows low solubility in water, bitter taste, and instability to oxidizing atmosphere. Considering the limitations for its suitable therapeutic use, the aim of the present study was to obtain, to characterize, to quantify, and to evaluate the stability of HT-loaded poly(ԑ-caprolactone) nanocapsules for its further use in pharmaceutical and nutraceutical products. Nanocapsules were prepared by method of interfacial deposition of the preformed polymer. The formulations were characterized by morphological and spectroscopic methods. The UHPLC-PDA analytical method was developed and validated for quantifying the HT encapsulation. Physicochemical stability assay was performed for 120 days. Nanocapsules were successfully obtained by the proposed method. The morphological evaluation demonstrated the drug absence in the nanocapsule surface. Fourier-transform infrared spectroscopy demonstrated the drug nanoencapsulation. The analytical method was validated and confirmed a high HT encapsulation efficiency over 95%. Considering the physicochemical stability testing, the polydispersity index changed after 30 days for NC-2 (HT at 2 mg/mL) and after 90 days for NC-5 (HT at 5 mg/mL). Zeta potential changed after 60 days for both formulations (NC-2 and NC-5). pH values were modified after 60 days for NC-5 and after 90 days for NC-2. HT-loaded PCL nanocapsules demonstrate adequate physicochemical features and high drug encapsulation. The different formulations revealed stability changes from 30 to 90 days. Additional in vitro and in vivo evaluations may be performed in order to use these nanoformulations for treating several diseases based on oxidative-inflammatory environments.

https://doi.org/10.1590/1678-4324-2023230081

Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
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Basquiera, Ana Lisa

; Bobillo, María Silvina Odstrcil

; Peroni, María Leticia

; Thomas, Diego Sanchez

; Vitriu, Adriana

; Berro, Mariano

; Ostriz, Belen Rosales

; Milovic, Vera

; Rolón, Juliana Martinez

; Jaimovich, Gregorio

; Krogh, Daniela Hansen

; Tagliafichi, Viviana

; Bisigniano, Liliana

; Arbelbide, Jorge Alberto

; Giunta, Diego Hernán

Hematology, Transfusion and Cell Therapy

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2023, Volume 45 Nº 2 Páginas 224 - 234

Resumo: En | Texto: En | PDF: En

Special Article Introduction Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7-165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5-275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p< 0.01). No changes were observed for unrelated donors during the study period. Conclusions Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.

https://doi.org/10.1016/j.htct.2022.02.008

Tromboprofilaxis en pacientes hospitalizados: implementación de un programa multifacético
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Vázquez, Fernando J.

; Grande Ratti, María F.

; Posadas-Martinez, María L.

; Elizondo, Cristina M.

; Giunta, Diego

; Rodríguez, Viviana

Medicina (Buenos Aires)

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Mai 2022, Volume 82 Nº 2 Páginas 223 - 230

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen La enfermedad tromboembólica venosa es la causa prevenible más frecuente de muerte hospitalaria. A pesar de contar con evidencia y recomendaciones sobre la utilidad de la tromboprofilaxis, la adherencia por parte de los médicos a las mismas es muy variable, y frecuentemente subóptima. El objetivo de este estudio fue evaluar un programa institucional con estrategias multifacéticas dirigido a médicos, sobre tromboprofilaxis en internación y estimar el cambio en la adecuación de la tromboprofilaxis antes y después de la intervención. La intervención se mantuvo durante 6 años, fue múltiple, utilizando acciones pasivas como car telería, y activas, como educación médica continua, confección y adopción de una guía institucional de práctica clínica y un sistema de soporte informático para la decisión clínica. La adecuación basal de la tromboprofilaxis mejoró de 59% a 82% después de la intervención y se mantuvo en el tiempo. La mejora en la adecuación se asoció a una reducción de los sangrados mayores, en particular en pacientes intervenidos quirúrgicamente.

Abstract Venous thromboembolic disease is the most common preventable cause of hospital death. Despite the existence of evidence of the usefulness of thromboprophylaxis and recommendations, adherence by physicians to them is highly variable, and frequently suboptimal. The objective was to evaluate the change in the adequacy of thromboprophylaxis before and after an intervention on thromboprophylaxis with multifaceted strategies for physicians. The intervention was a 6 years institutional program with multiple strategies: passive actions such as posters and active actions as continuous medical education, adaptation of an institutional clinical practice guide and a computerized clinical decision support system. The baseline adequacy of thromboprophylaxis improved from 59% to 82% and was maintained over time. The improvement in fitness was associated with a reduction in major bleeding, particularly in patients undergoing surgery.

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Recomendaciones de la Asociación Colombiana de Neurología para el uso de anticuerpos monoclonales antiCGRP en la profilaxis de migraña
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Pradilla, Oscar Enrique

; Martinez, José David

; Rueda-Sánchez, Mauricio

; Sobrino, Fidel

; Jiménez, Juan Diego

; Ramírez, Sergio Francisco

; Muñoz-Cerón, Joe Fernando

; Volcy, Michel

; Guerra, Carolina

; Ramos, Marta Liliana

; Arango, Esteban

; Uribe, Bernardo

; Cavanzo, Paula

; Hernández, Natalia

Acta Neurológica Colombiana

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Mar 2022, Volume 38 Nº 1 Páginas 1 - 22

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT INTRODUCTION: The development of monoclonal antibodies (mAbs) against Calcitonin Gene Related Peptide (CGRP) has determined a new therapeutic era in migraine prophylaxis, demonstrating its effectiveness in patients with episodic migraine (EM) and chronic migraine (CM), obtaining a response in naive patients and in those who are refractory to multiple medications. A 50% decrease in migraine attacks per month during the first 3 months of use is the approximate outcome in 50% of patients receiving this therapy. OBJECTIVE: This consensus from the Colombian Association of Neurology (ACN) has the objective of serving as a guide for the rational use of antiCGRP mAbs in patients with EM and CM. METHODS AND MATERIALS: The headache committee through the application of the Delphi methodology and discussions in subsequent meetings, develops this consensus, supported in the published literature and expert recommendations. RESULTS: Fourteen answers from headache experts were received regarding the use of drugs for migraine prophylaxis, analyzing their applicability in frequent clinical situations. DISCUSSION: AntiCGRP mAbs have proved their effectiveness with adequate pathophysiological support, but with a high price in a highly prevalent disease, there is then a need to select the patient who best benefits from this therapy. CONCLUSIONS: AntiCGRP mAbs are recommended in patients with EM and CM that have previously failed to other prophylactic drugs.

RESUMEN INTRODUCCIÓN: El desarrollo de anticuerpos monoclonales (mAbs) contra el péptido relacionado con el gen de la calcitonina (CGRP) ha determinado una nueva era terapéutica en la profilaxis de migraña, demostrando su efectividad en pacientes con migraña episódica (ME) y migraña crónica (MC), con respuesta desde pacientes naïve hasta refractarios a múltiples medicamentos. La disminución del 50% de los ataques de migraña al mes (DMM) durante los primeros 3 meses de uso es el desenlace aproximado en el 50% de los pacientes que reciben esta terapia. OBJETIVO: Este consenso de la Asociación Colombiana de Neurología (ACN) tiene el objetivo de guiar la selección y uso racional de los mAbs antiCGRP en pacientes con ME y MC. MATERIALES Y MÉTODOS: El comité de cefalea de la ACN mediante la aplicación de la metodología Delphi y discusiones en reuniones posteriores desarrolló un documento en formato de consenso soportado en literatura y recomendaciones de expertos. RESULTADOS: Se obtuvieron respuestas de 14 expertos en cefalea sobre moléculas utilizadas en profilaxis de migraña, analizando su aplicabilidad en situaciones clínicas frecuentes. DISCUSIÓN: Los mAbs antiCGRP han demostrado efectividad con adecuado soporte fisiopatológico, considerando que son moléculas de alto precio en una enfermedad de alta prevalencia, existe la necesidad de guíar la selección del paciente que mejor puede beneficiarse de su administración CONCLUSIONES: Los mAbs antiCGRP están recomendados en pacientes con ME y MC que presentan falla terapéutica a otras moléculas profilácticas.

https://doi.org/10.22379/24224022401 94 downloads

Teaching Rheumatology in the undergraduate: It is enough?
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Karam, Claudia Mora

; Beltrán, Adriana

; Restrepo, Jorge

; Sierra, Rita

; Guerrero, Yully Andrea

; Martinez, Diego Camilo

Revista Colombiana de Reumatología

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Mar 2022, Volume 29 Nº 1 Páginas 38 - 43

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Musculoskeletal disorders (MSD) are the second leading cause of disability worldwide. There are difficulties in the early diagnosis and therapeutic approach to these pathologies, with a negative impact on their outcomes. Access to rheumatology is limited, with a low supply in the face of growing demand, which makes the general practitioner the first contact for care. Objectives: Describe the perception and confidence that general practitioners have regarding the training in rheumatology received at undergraduate level. Materials and methods: Observational cross-sectional study, with a Likert-type survey tool being used. The study included general practitioners graduated from the Colombian Medicine program between 2009 and 2019. The variables studied were those related to the curriculum, acquired knowledge or skills, and proficiency in content in rheumatol ogy compared to practice. Subjects who attended a specialist or who had an employment relationship with a specialist rheumatology centre were excluded. Results and Conclusions: A total of 102 physicians were surveyed, and 86 completed ques tionnaires were included in the final analysis. Of these, 83.4% were graduates of private universities. Over two-thirds (37%9) had a formal subject in rheumatology, 16% received training with specific strategies, 54% expressed security when performing the MS physical examination, and 47% were sure in the diagnostic approach, and prescription of disease-modifying drugs. In order to strengthen the training in rheumatology required by the undergraduate, a joint effort is required with the medical schools in defining the competen cies and skills of the primary care physician, together with the health needs and available educational strategies.

RESUMEN Introducción: Las enfermedades musculoesqueléticas (ME) son la segunda causa de discapa cidad mundial. Se presentan dificultades en el enfoque diagnóstico y terapéutico temprano de estas enfermedades, lo cual tiene un impacto negativo en sus desenlaces. El acceso a Reumatología es limitado, con una baja oferta frente a la creciente demanda, lo que convierte al médico general en el primer contacto de atención. Objetivos: Describir la percepción y la confianza que tienen los médicos generales respecto a la formación en reumatología recibida en el pregrado. Materiales y métodos: Estudio observacional de corte transversal en el cual se indagó a médi cos generales, egresados de programas de medicina colombianos entre el 2009 y 2019, mediante un cuestionario con respuesta tipo Likert, sobre variables relacionadas con el planteamiento curricular, los conocimientos o habilidades adquiridas y la suficiencia en el contenido en reumatología con respecto a la práctica. Se excluyó a los sujetos que cur saran algún programa de especialización o que tuvieran relación laboral con un centro especializado de Reumatología. Resultados y conclusiones: Se encuestó a 102 médicos; 86 encuestas fueron incluidas en el análisis final. El 83,4% de ellos eran egresados de universidades privadas, el 37% contó con una asignatura formal de reumatología, el 16% recibió formación con estrategias específicas, el 54% manifestó seguridad al realizar el examen físico musculoesquelético, el 47% expresó sentirse seguro en el enfoque diagnóstico y la prescripción de medicamentos modificadores de la enfermedad. Es necesario fortalecer la formación en Reumatología en el pregrado; se requiere un trabajo conjunto con las facultades de medicina en la definición de competen cias del médico de Atención Primaria, alineado con las necesidades de salud y las estrategias educacionales disponibles.

https://doi.org/10.1016/j.rcreu.2020.11.006

Presencia de bacterias en bombillas para infusiones y en cavidad oral de pacientes con salud periodontal y antecedentes de enfermedad periodontal: análisis exploratorio.
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Monges, Lider

; Defazio, Diego

; Martinez, Gisselle

; Rios-González, Carlos Miguel

Memorias del Instituto de Investigaciones en Ciencias de la Salud

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Dez 2021, Volume 19 Nº 3 Páginas 54 - 60

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT The retention and survival of oral microorganisms (OM) in the bombillas to take infusions represents a possible source of contamination of the mouth, mainly in people with periodontal diseases. The objective was to identify the presence of bacteria in infusion bombillas and in the oral cavity of patients with periodontal health and a history of periodontal disease. This was an observational, descriptive, cross-sectional study with analytical component. Study participants were grouped into G1 (patients with periodontal health, sterile infusion bulbs, with ethylene oxide for use for 30 days) and G2 (patients with a history of periodontal disease, sterile infusion bulbs, with ethylene oxide for use for 30 days). Fifty patients participated in the study. In healthy patients (Group1) the mean CFU was 676 ± 226, while in patients with periodontal disease (Group 2) the mean of Colony Forming Units (CFU) was 817 ± 345. In healthy patients (Group1) the mean OM It was 668 ± 165, while in patients with periodontal disease (Group 2) the mean OM was 774 ± 156. The presence of microorganisms is evidenced in bombillas for infusions and in the oral cavity of patients with periodontal health and a history of periodontal disease. The count of CFU present in the oral cavity of patients with periodontal health and a history of periodontal disease was similar.

RESUMEN La retención y sobrevivencia de microorganismos orales (MO) en la bombilla para tomar infusiones representa una posible fuente de contaminación de la boca, principalmente en personas con enfermedades periodontales. El objetivo del trabajo fue identificar la presencia de bacterias en bombillas para infusiones y en cavidad oral de pacientes con salud periodontal y antecedentes de enfermedad periodontal. Este fue un estudio observacional, descriptivo de corte transversal con componente analítico. Los participantes del estudio se agruparon en G1 (pacientes con salud periodontal, bombillas estériles para infusiones, con oxido etileno para su uso por 30 días) y G2 (pacientes con antecedente de enfermedad periodontal, bombillas estériles para infusión, con oxido etileno para su uso por 30 días). Participaron del estudio 50 pacientes. En los pacientes sanos (Grupo1) el promedio de Unidades Formadoras de Colonias (UFC) fue de 676± 226, mientras que en los pacientes con enfermedad periodontal (Grupo 2) el promedio de UFC fue de 817± 345. En los pacientes sanos (Grupo1) el promedio de MO fue de 668± 165, mientras que en los pacientes con enfermedad periodontal (Grupo 2) el promedio de MO fue de 774± 156. Se evidencia la presencia de microorganismos en bombillas para infusiones y en cavidad oral de pacientes con salud periodontal y antecedentes de enfermedad periodontal. El recuento de UFC presentes en la cavidad oral de los pacientes con salud periodontal y antecedentes de enfermedad periodontal fue similar.

https://doi.org/10.18004/mem.iics/1812-9528/2021.019.03.54 82 downloads

10.

Abordaje inicial del paciente intoxicado por monóxido de carbono: Una aproximación terapéutica
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Serna-Trejos, Juan Santiago

; Martinez-Parada, Isabella

; Agudelo-Quintero, Esteban

; Prado-Molina, Diego Gerardo

Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo

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Dez 2021, Volume 14 Nº 4 Páginas 619 - 620

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.35434/rcmhnaaa.2021.144.1475

11.

Situación actual de Candida auris en Colombia, 2021
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Martinez-Parada, Isabella

; Agudelo-Quintero, Esteban

; Prado-Molina, Diego Gerardo

; Serna-Trejos, Juan Santiago

Anales de la Facultad de Medicina

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Jul 2021, Volume 82 Nº 3 Páginas 242 - 243

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.15381/anales.v82i3.21089

12.

Dietary hybrid phytase and carbohydrases on nutrient digestibility and bone quality of broiler chickens
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Bavaresco, Caroline

; Krabbe, Everton Luis

; Surek, Diego

; Gopinger, Edenilse

; Martinez, Fernando Nicolas

; Wernick, Bruno

; Roll, Victor Fernando Büttow

Pesquisa Agropecuária Brasileira

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2021, Volume 56 elocation e01668

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi avaliar a eficiência do uso de fitase híbrida, associada ou não com carboidrases, em dietas para frangos, com reduções nutricionais de cálcio, fósforo disponível e energia metabolizável, sobre a digestibilidade dos nutrientes e a qualidade óssea em frangos de corte. Um total de 1.875 frangos foi distribuído em cinco tratamentos, em delineamento inteiramente casualizado, com 15 repetições de 25 frangos cada uma. Os tratamentos consistiram de uma dieta controle positivo (T1) e de quatro controles negativos (T2 a T5): T1, dieta basal (DB) de milho e farelo de soja; T2 e T3, DBs com reduções de 70 e 100 kcal kg-1 de energia metabolizável, respectivamente, e ambas com reduções de 0,16% de Ca e 0,15% de fósforo disponível; e T4 e T5, DBs com as mesmas reduções nutricionais, mas com a adição de enzimas, ou seja, T4 = T2 + 500 unidades de fitase (FTU) por quilograma e T5 = T3 + 500 FTU kg-1 + 560 unidades de xilanase (TXU) por quilograma + 250 unidades de glucanase (TGU) por quilograma. O uso de 500 FTU kg-1 de fitase híbrida em rações peletizadas com milho e farelo de soja permite bom desempenho digestivo por frangos de corte e substitui a energia metabolizável aparente corrigida por nitrogênio a 70 kcal kg-1, bem como 0,16% de Ca e 0,15% de P disponível.

Abstract The objective of this work was to evaluate the effect of the use of hybrid phytase, alone or combined with carbohydrases, in poultry diets with nutritional reductions of calcium, available phosphorus, and metabolizable energy on the nutrient digestibility and bone quality of broiler chickens. A total of 1,875 broilers were distributed in five treatments in a completely randomized design, with 15 replicates of 25 chickens each. The treatments consisted of a positive control feed (T1) and of four negative controls (T2 to T5): T1, basal diet (BD) with corn and soybean; T2 and T3, BDs with reductions of 70 and 100 kcal kg-1 metabolizable energy, respectively, and both with reductions of 0.16% Ca and 0.15% available P; and T4 and T5, BDs with the same nutritional reductions, but supplemented with enzymes, i.e., T4 = T2 + 500 phytase units (FTU) per kilogram and T5 = T3 + 500 FTU kg-1 + 560 xylanase units (TXU) per kilogram + 250 glucanase units (TGU) per kilogram. The use of 500 FTU kg-1 hybrid phytase in pelleted corn-soybean meal diets allows a good digestive performance by broilers and replaces the nitrogen-corrected apparent metabolizable energy at 70 kcal kg-1, as well as 0.16% Ca and 0.15% available P.

https://doi.org/10.1590/s1678-3921.pab2021.v56.01668

13.

Arqueología republicana en Antofagasta de la Sierra, puna de Atacama: un abordaje desde los espacios internodales y espacios domésticos
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Martinez, M. Soledad

; Zamora, Diego

Estudios atacameños

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2021, Volume 67 elocation 14

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: In this paper we present the results of archaeological research focused on the Republican Period (XIX and XX centuries) in Antofagasta de la Sierra, in the actual Argentinian southern Puna (the Atacama Puna). We are going to expose the ways of inhabit the territory by the Puna population during the rising and consolidation of the State, taking into account practices of consumption in two spatial dimensions: 1. The domestic one, represented by an “estancia” -a rural house or farmstead, linked to the town of Antofagasta de la Sierra, and 2. The internodal areas, or the “empty spaces” in which the circulation, traffic and other activities were done. We will particularly discuss issues related to the puneño way of life -related to daily activities, migratory herding, and long distance travelling, their continuities and discontinuities, adoptions and resistances from ontologies that move us away from traditional Cartesian dichotomies, in such a way to link notions such as memory, landscape, territory and mobility in the Puna area.

Resumen: En este trabajo abordamos aspectos de la ocupación en la actual puna meridional argentina (puna de Atacama) durante el Período Republicano (siglos XIX y XX) a través de casos de estudio arqueológicos de Antofagasta de la Sierra y El Peñón. Exponemos una de las múltiples formas de habitar el territorio por parte de las poblaciones puneñas durante la conformación y consolidación del Estado-nación, abordando ciertas prácticas de consumo en dos dimensiones espaciales: 1. la doméstica, representada en una estancia vinculada al poblado de Antofagasta de la Sierra, y 2. las comprendidas por las áreas internodales, o los espacios “vacíos” en los que se daba la circulación, la trashumancia y otras actividades. A partir de nuestros casos de análisis, discutimos en particular cuestiones vinculadas a la incidencia del Estado-nación en el modo de vida puneño -en relación a las prácticas cotidianas, el pastoralismo trashumante y la realización de viajes a larga distancia- sus continuidades y discontinuidades, adopciones y resistencias desde otras ontologías que nos alejen de las dicotomías cartesianas tradicionales, de manera de abordar el vínculo entre nociones tales como memoria, paisaje, territorialidad y movilidad en el área puneña.

https://doi.org/10.22199/issn.0718-1043-2021-0014 210 downloads

14.

Altrenogest during early pregnancy modulates uterine glandular epithelium and endometrial growth factor expression at the time implantation in pigs
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Muro, Bruno Bracco Donatelli

; Leal, Diego Feitosa

; Carnevale, Rafaella Fernandes

; Torres, Mariana Andrade

; Mendonça, Maitê Vidal

; Nakasone, Denis Hideki

; Martinez, Cristian Hernando Garcia

; Ravagnani, Gisele Mouro

; Monteiro, Matheus Saliba

; Poor, André Pegoraro

; Martins, Simone Maria Massami Kitamura

; Viau, Priscila

; Oliveira, Cláudio Alvarenga de

; Castro, Raquel Vasconcelos Guimarães de

; Bessi, Brendon Willian

; Bressan, Fabiana Fernandes

; Pulz, Lidia Hildebrand

; Strefezzi, Ricardo Francisco

; Almond, Glen William

; Andrade, André Furugen Cesar de

Animal Reproduction

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2021, Volume 18 Nº 1 elocation e20200431

Resumo: En | Texto: En | PDF: En

Abstract This study evaluated the effects of supplying altrenogest from day 6-12 of pregnancy on the endometrial glandular epithelium, corpora lutea (CL) morphology, and endometrial and CL gene expression. A total of 12 crossbred females (Landrace × Large White) were used. The females were assigned to 4 treatments according to a random design with a 2 × 2 factorial arrangement, with two categories (sow or gilt) and two treatments (non-treated and treated with altrenogest). On day 6 of pregnancy, animals were allocated to one of the following groups: non-treated (NT, n = 6; 3 sows and 3 gilts), and (T, n = 6; 3 sows and 3 gilts) treated daily with 20 mg of altrenogest, from day 6-12 of pregnancy. All animals were euthanized on day 13 of pregnancy. All CLs were individually weighed, and their volume were determined. The endometrial glandular density (GD), mean glandular area (MGA), and vascular density (VD) were determined by histomorphometric and immunohistochemical analyses. Endometrium samples were collected and analyzed by qRT-PCR to evaluate the abundance of transcripts for VEGF and IGF-I. Females in the T group had higher MGA (P < 0.05) compared to the NT group. There was no effect of treatment on GD or VD for both experimental groups. Sows in the T group had augmented expression of IGF-I (P < 0.05). Progestagen had no detrimental effect on CL morphology. In conclusion, altrenogest improves the uterine environment during the peri-implantation period in pigs without compromising corpora lutea development.

https://doi.org/10.1590/1984-3143-ar2020-0431 127 downloads

15.

Prevalence of virological and serological markers of SARS-CoV-2 infection in the population of Ribeirão Preto, Southeast Brazil: an epidemiological survey
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Martinez, Edson Zangiacomi

; Passos, Afonso Dinis Costa

; Fabbro, Amaury Lelis Dal

; Silva, Anderson Soares da

; Escarso, Andreia Cássia

; Pazin-Filho, Antônio

; Fonseca, Benedito Antônio Lopes da

; Maciel, Benedito Carlos

; Araújo, Daniel Cardoso de Almeida e

; Clé, Diego Villa

; Gaspar, Gilberto Gambero

; Santos, Jair Lício Ferreira dos

; Ferreira, Janise Braga Barros

; Souza, João Paulo

; Mello, Luane Marques de

; Santos, Luciane Loures dos

; Passos, Luzia Márcia Romanholi

; Siconelli, Márcio Junio Lima

; Cavalli, Ricardo de Carvalho

; Santana, Rodrigo de Carvalho

; Calado, Rodrigo do Tocantins

; Scarpelini, Sandro

; Bollela, Valdes Roberto

; Floriano, Vitor Gonçalves

; Bellissimo-Rodrigues, Fernando

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0210-2021

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: This epidemiological household survey aimed to estimate the prevalence of the current and past SARS-CoV-2 infections in Ribeirão Preto, a municipality of southeast Brazil. METHODS: The survey was conducted in two phases using a clustered sampling scheme. The first phase spanned May 1-3 and involved 709 participants. The second phase spanned June 11-14, 2020, and involved 646 participants. RESULTS: During the first phase, RT-PCR performed on nasopharyngeal swabs was positive at 0.14%. The serological tests were positive in 1.27% of the patients during the first phase and 2.79% during the second phase. People living in households with more than five members had a prevalence of 10.83% (95%CI: 1.58-74.27) higher than those living alone or with someone other. Considering the proportion of the positive serological test results with sex and age adjustments, approximately 2.37% (95%CI: 1.32-3.42) of the population had been cumulatively infected by mid-June 2020, which is equivalent to 16,670 people (95%CI: 9,267-24,074). Considering that 68 deaths from the disease in the residents of the city had been confirmed as at the date of the second phase of the survey, the infection fatality rate was estimated to be 0.41% (95%CI: 0.28-0.73). Our results suggest that approximately 88% of the cases of SARS-CoV-2 infection at the time of the survey were not reported to the local epidemiological surveillance service. CONCLUSIONS: The findings of this study provide in-depth knowledge of the COVID-19 pandemic in Brazil and are helpful for the preventive and decision-making policies of public managers.

https://doi.org/10.1590/0037-8682-0210-2021 117 downloads

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