Pesquisa | SciELO

Abstract Background: Colorectal cancer (CRC) is the second cause of cancer death in the world and is estimated to have been responsible for almost 935,000 deaths during 2020. Objective: Describe clinicopathological features, overall survival (OS) and progression-free survival (PFS) in CRC patients under 30 years. Method: This is a retrospective cohort study in patients under 30 years diagnosed with CRC. Results: From 2017 to 2021, 1823 patients were diagnosed with CRC, of which 54 (2.96%) were under 30 years. The OS, during 4 years, was 41.5%. The clinical stage found IV (hazard ratio [HR]: 6.212; 95% confidence interval [95% CI]: 2.504-15.414; p < 0.001), giving neoadjuvant therapy (HR: 0.705; 95% CI: 0.499-0.996; p = 0.047) and no medical history of Lynch syndrome (HR: 3.925; 95% CI: 1.355-11.364; p = 0.012) are independent predictors of mortality. The PFS, during 4 years, was 21.3%. Clinical stage IV (HR: 2.418; 95% CI: 1.000-5.850; p < 0.050), and no diagnosis of Lynch syndrome (HR: 3.800; 95% CI: 1.398-10.326; p = 0.009) are independent predictors. Conclusions: Younger patients are usually diagnosed with CRC in advanced stages. Early symptoms and evaluation, irrespective of age, are crucial.

Resumen Antecedentes: El cáncer colorrectal (CCR) es la segunda causa de muerte por cáncer en el mundo y se estima que fue responsable de casi 935,000 muertes durante el año 2020. Objetivo: Describir las características clinicopatológicas, la supervivencia global (SG) y la supervivencia libre de progresión (SLP) en pacientes con CCR menores de 30 años. Método: Estudio de cohorte retrospectivo en pacientes con diagnóstico de CCR menores de 30 años. Resultados: Entre 2017 y 2021 se diagnosticaron 1823 pacientes con CCR, de los cuales 54 (2.96%) eran menores de 30 años. La SG a 4 años fue del 41.5%. Se encontró que la etapa clínica IV (hazard ratio [HR]: 6.212; intervalo de confianza del 95% [IC95%]: 2.504-15.414; p < 0.001), recibir tratamiento neoadyuvante (HR: 0.705; IC95%: 0.499-0.996; p = 0.047) y no tener antecedente de síndrome de Lynch (HR:3.925; IC95%: 1.355-11.364; p = 0.012) son predictores de mortalidad independientes. La SLP a 4 años fue del 21.3%. La etapa clínica IV (HR: 2.418; IC95%: 1.000-5.850; p < 0.050) y el no contar con diagnóstico de síndrome de Lynch (HR: 3.800; IC95%: 1.398-10.326; p = 0.009) son predictores independientes. Conclusiones: Los pacientes jóvenes son diagnosticados con CCR en etapas avanzadas. Los síntomas iniciales, junto con la evaluación, independientemente de la edad, son cruciales.

https://doi.org/10.24875/ciru.22000467

Enfermedad invasiva por Haemophilus influenzae: reporte de 14 casos luego de un año de iniciada la pandemia por COVID-19
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Juárez, Ximena

; Flores Yavi, Rebeca

; Balboa, Romina

; Matteucci, Erika

; Burundarena, Carmen

; Causarano, María F.

; Miranda, Sandra

; Dondoglio, Patricia

; Echave, Cecilia

; Pereda, Rosana

; Cancellara, Aldo

Archivos argentinos de pediatría

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Out 2023, Volume 121 Nº 4 Páginas 1 - 1

Resumo: Es | Texto: Es | PDF: Es

El Haemophilus influenzae (Hi) causa enfermedad invasiva (EI). Se distinguen cepas capsuladas, como el serotipo b (Hib), y cepas no tipificables (HNT). Al año de declarada la pandemia por COVID-19, observamos un aumento de casos. Se describen las características clínico-epidemiológicas de niños con EI por Hi internados en el hospital (julio 2021-julio 2022). Hubo 14 casos; 12 previamente sanos. Aislamientos: Hib (n = 6), Hi serotipo a (n = 2), HNT (n = 5), 1 no se tipificó. Mediana de edad: 8,5 meses (RIC 4-21). Manifestaciones: meningitis (n = 5), neumonía (n = 6), celulitis (n = 2), artritis (n = 1). Nueve presentaron vacunación incompleta para Hib. Observamos un incremento de EI por Hi de 2,5 veces respecto a años previos. Estos datos sugieren el resurgimiento de Hib por la caída de las coberturas de vacunación y porque otras cepas de Hi no b están en aumento.

https://doi.org/10.5546/aap.2022-02805

Comparación de la violencia y agresiones sufridas por el personal de salud durante la pandemia de COVID-19 en Argentina y el resto de Latinoamérica
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Garcia-Zamora, Sebastián

; Iomini, Pablo A.

; Pulido, Laura

; Miranda-Arboleda, Andrés F.

; Lopez-Santi, Pilar

; Burgos, Lucrecia M.

; Perez, Gonzalo E.

; Priotti, Mauricio

; García, Darío E.

; Antoniolli, Melisa

; Musso, Gabriel

; Zaidel, Ezequiel J.

; Sosa-Liprandi, Álvaro

; Del-Sueldo, Mildren A.

; Lopez-Santi, Ricardo

; Vazquez, Gustavo

; Baranchuk, Adrián

Revista Peruana de Medicina Experimental y Salud Pública

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Jun 2023, Volume 40 Nº 2 Páginas 179 - 188

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Objetivos. Explorar la frecuencia e impacto de la violencia contra los trabajadores de salud de Argentina y compararlo con el resto de sus pares de Latinoamérica en el contexto de la pandemia por COVID-19. Materiales y métodos. Estudio de corte transversal a través de una encuesta electrónica al personal médico y no médico de Latinoamérica que desempeño tareas asistenciales desde marzo de 2020. Se utilizó una regresión de Poisson para estimar las Razones de Prevalencia crudas (RP) y ajustadas (RPa) con sus respectivos intervalos de confianza al 95%. Resultados. Un total de 3544 participantes de 19 países respondieron la encuesta; 1992 (56,0%) residían en Argentina. Entre los mismos, el 62,9% padeció al menos un hecho de violencia: 97,7% refirió violencia verbal y 11,8% violencia física. El 41,5% de los agredidos padecieron situaciones de violencia al menos una vez por semana. El personal de salud de Argentina vivenció más frecuentemente violencia que los de otros países (62,9% vs. 54,6%, p<0,001), siendo estos eventos más habituales y estresantes (p<0,05). Además, refirieron más frecuentemente haber considerado cambiar sus tareas asistenciales y/o deseos de abandonar su profesión (p<0,001). En la regresión de Poisson, los participantes de Argentina tuvieron una prevalencia de violencia mayor que los trabajadores de salud de la región (14,6%; p<0,001). Conclusiones. Existió una elevada prevalencia de violencia contra el personal de salud de Argentina durante la pandemia por COVID-19. Estos hechos tuvieron un alto impacto negativo entre quienes los padecieron. Nuestros datos sugieren que, esto podría haber sido más frecuente en Argentina respecto de otras regiones del continente.

ABSTRACT Objectives. To explore the frequency and impact of violence against healthcare workers in Argentina and to compare it with the rest of their Latin American peers during the COVID-19 pandemic. Materials and methods. A cross-sectional study was conducted by applying an electronic survey on Latin American medical and non-medical personnel who carried out health care tasks since March 2020. We used Poisson regression to estimate crude (PR) and adjusted (aPR) Prevalence Ratios with their respective 95% confidence intervals. Results. A total of 3544 participants from 19 countries answered the survey; 1992 (56.0%) resided in Argentina. Of these, 62.9% experienced at least one act of violence; 97.7% reported verbal violence and 11.8% physical violence. Of those who were assaulted, 41.5% experienced violence at least once a week. Health personnel from Argentina experienced violence more frequently than those from other countries (62.9% vs. 54.6%, p<0.001), and these events were more frequent and stressful (p<0.05). In addition, Argentinean health personnel reported having considered changing their healthcare tasks and/or desired to leave their profession more frequently (p<0.001). In the Poisson regression, we found that participants from Argentina had a higher prevalence of violence than health workers from the region (14.6%; p<0.001). Conclusions. There was a high prevalence of violence against health personnel in Argentina during the COVID-19 pandemic. These events had a strong negative impact on those who suffered them. Our data suggest that violence against health personnel may have been more frequent in Argentina than in other regions of the continent.

https://doi.org/10.17843/rpmesp.2023.402.12646

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad extensa
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Cabrera-Miranda, Luis A.

; Díaz-García, Diego A.

; Corona-Cruz, José F.

; Lozano-Ruiz, Francisco J.

; Sánchez-Reyes, Roberto

; Álvarez-Bojórquez, Mario E.

; Blake-Cerda, Mónika

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Pérez-Álvarez, Sandra I.

; Bolaño-Guerra, Laura M.

; Alatorre-Alexander, Jorge A.

; Alexander-Meza, Francisco

; Barrón-Barrón, Feliciano

; Blanco-Vázquez, Yazmín C.

; Campos-Gómez, Saúl

; Mata-Moya, Dolores de la

; Figueroa-Martínez, Pedro

; González-Cisneros, Paulina E.

; Íñiguez-García, Marco A.

; Lázaro-León, Jesús M.

; Loyola-García, Ulises

; Morales-Rivera, Marcelino

; Olivares-Torres, Carlos

; Ramos-Ramírez, Maritza

; Sáenz-Frías, Julia A.

; Silva-Bravo, Fernando

; Trejo-Rosales, Rogelio

; Souto-del Bosque, Miguel

; Arrieta, Óscar

Gaceta mexicana de oncología

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Jun 2023, Volume 22 Nº 2 Páginas 55 - 73

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000122

Manejo del aneurisma de arteria ilíaca. Revisión bibliográfica
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Arias-Rodríguez, Fabián D.

; Alarcón-Salas, Iván D.

; Anda, Daniela E.

; Miranda-Villagómez, Andrea F.

; Bustillos-Rodríguez, Álvaro V.

; Carvajal-Barzallo, Kevin A.

; Barbosa-Velasteguí, Xiomara A.

; Romero-Tumbaco, Flor P.

; Granja-Caiza, Jennifer D.

; González-Miranda, Kelly S.

Revista mexicana de angiología

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Jun 2023, Volume 51 Nº 2 Páginas 55 - 64

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Los aneurismas de arteria ilíaca solitarios son menos frecuentes que otros aneurismas de grandes vasos, siendo en la mayoría detectados junto con un aneurisma de aorta abdominal concomitante. Comparten la misma etiología aterosclerótica-degenerativa, siendo así que sus factores de riesgo son los mismos que para otros aneurismas. Generalmente son asintomáticos y se detectan incidentalmente, y cuando son sintomáticos, están en relación con la compresión de estructuras adyacentes y la ruptura del aneurisma. Los aneurismas de la arteria ilíaca común son los más comunes, seguidos de los aneurismas ilíacos internos y luego externos. Actualmente existe una variedad de opciones quirúrgicas abiertas, endovasculares e híbridas para tratar los aneurismas de la arteria ilíaca. La anatomía de la arteria ilíaca común con respecto al cuello proximal y distal, la afectación de la bifurcación ilíaca y la elección de preservar la arteria ilíaca interna ipsilateral juegan un papel en el proceso de decisión hacia el método de tratamiento preferido.

Abstract Isolated iliac artery aneurysms are less common than other large-vessel aneurysms, and most are detected together with a concomitant abdominal aortic aneurysm. It shares the same atherosclerotic-degenerative etiology since its risk factors are the same as for other aneurysms. They are generally asymptomatic, being detected incidentally and when they are symptomatic, they are related to the compression of adjacent structures and the rupture of the aneurysm. Common iliac artery aneurysms are the most common, followed by internal and then external iliac aneurysms. Currently, a variety of open, endovascular, and hybrid surgical options exist to treat iliac artery aneurysms. The anatomy of the common iliac artery with respect to the proximal and distal neck, the involvement of the iliac bifurcation, and the choice to preserve the ipsilateral internal iliac artery all play a role in the decision process towards the preferred method of treatment.

https://doi.org/10.24875/rma.22000043

Comparación de la violencia y agresiones sufridas por el personal de salud durante la pandemia de COVID-19 en Argentina y el resto de Latinoamérica
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Garcia-Zamora, Sebastián

; Iomini, Pablo A.

; Pulido, Laura

; Miranda-Arboleda, Andrés F.

; Lopez-Santi, Pilar

; Burgos, Lucrecia M.

; Perez, Gonzalo E.

; Priotti, Mauricio

; García, Darío E.

; Antoniolli, Melisa

; Musso, Gabriel

; Zaidel, Ezequiel J.

; Sosa-Liprandi, Álvaro

; Del-Sueldo, Mildren A.

; Lopez-Santi, Ricardo

; Vazquez, Gustavo

; Baranchuk, Adrián

Revista Peruana de Medicina Experimental y Salud Publica

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Abr 2023, Volume 40 Nº 2 Páginas 179 - 188

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

https://doi.org/10.17843/rpmesp.2023.402.12646

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad limitada
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Cabrera-Miranda, Luis A.

; Lozano-Ruiz, Francisco J.

; Blake-Cerda, Mónika

; Corona-Cruz, José F.

; Sánchez-Reyes, Roberto

; Pérez-Álvarez, Sandra I.

; Díaz-García, Diego A.

; Álvarez-Bojórquez, Mario E.

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Bolaño-Guerra, Laura M.

; Maldonado-Magos, Federico

; Aldaco-Sarvide, Fernando

; Alvarado-Zermeño, Adriana

; Barajas-Figueroa, Luis J.

; Bautista-Aragón, Yolanda

; Bolaños-Morales, Francina V.

; Castillo-Ortega, Graciano

; Félix-Leyva, Jesús A.

; Gerson-Cwilich, Raquel

; Guzmán-de Alba, Enrique

; López-Galindo, Ángel A.

; Mariscal-Ramírez, Carlos

; Piñeiro-Retif, Rafael

; Ramos-Prudencio, Rubí

; Rodríguez-Cid, Jerónimo

; Silva-Bravo, Fernando

; Arrieta, Óscar

Gaceta mexicana de oncología

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Mar 2023, Volume 22 Nº 1 Páginas 3 - 23

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP, enfermedad limitada, en México, basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración entre el Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensuaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad limitada, producto de las preguntas de trabajo. Se identificó y evaluó críticamente la evidencia científica que responde a cada una de dichas preguntas clínicas, antes de incorporarla a la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad limitada del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica en estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by rapid growth rate and development of distant metastases. Objectives: To guide and standardize the treatment of limited disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: Consensus recommendations were reached, both by the Delphi method and in remote meetings, for limited SCLC disease resulting from the same number of work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the guide. Conclusion: This guide provides clinical recommendations for the management of limited disease SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000121

Low-Temperature Partitioning: A Simple Screening Method for Determining Diethylene Glycol in Beer by Gas Chromatography
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Azevedo, Mariane M.

; Miranda, Liany D. L.

; Queiroz, Maria Eliana L. R. de

; Oliveira, André F. de

; Pereira, Alexandre F.

; Neves, Antônio A.

; Silva, Thaís L. R.

Journal of the Brazilian Chemical Society

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Mar 2023, Volume 34 Nº 3 Páginas 452 - 460

Resumo: En | Texto: En | PDF: En

Diethylene glycol is an extremely toxic substance to humans. Recently, cases of beer contamination in Brazil have raised awareness of the need for developing simple screening methods to evaluate this type of compound. This research developed a liquid-liquid extraction with low-temperature partitioning technique to determine diethylene glycol in beer via gas chromatography. Employing a flame-ionization detector simplifies the method, lowers its cost and therefore, it can be used as screening step to assess the possibility of contamination. A gas chromatograph coupled to a mass spectrometer would be used only for a confirmatory analysis. The optimized method was validated for the main figures of merit, and it proved to be adequate, with good values of recovery rate (94-106%), limit of detection (3.0 mg L-1), and quantification (10.0 mg L-1). Accuracy, in terms of repeatability and intermediate accuracy, showed variation coefficients lower than or equal to 20%. This method was applied to 28 samples of beers marketed in Brazil, and diethylene glycol was found above the limit of detection in three of them (10.7%). These results were confirmed by a gas chromatograph coupled to a mass spectrometer, which showed the reliability of the screening method for determining diethylene glycol in beer samples.

https://doi.org/10.21577/0103-5053.20220123

USO DA ANÁLISE BIBLIOMÉTRICA COMO FERRAMENTA PARA O LEVANTAMENTO DE ESTUDOS SOBRE A METABOLÔMICA APLICADA NA BIORREMEDIAÇÃO DE ÁREAS IMPACTADAS POR HIDROCARBONETOS
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Costa, Bruna P. da

; Dantas, Camila P.

; Miranda, Beatriz B.

; Lima, Danusia F.

; Oliveira, Olívia Maria C. de

; Garcia, Karina S.

; Canuto, Gisele A. B.

; Teixeira, Leonardo S. G.

Química Nova

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Fev 2023, Volume 46 Nº 2 Páginas 179 - 184

Resumo: Pt | Texto: Pt | PDF: Pt

Bibliometric reviews, carried out from access to databases of scientific articles associated with software for data processing, can be helpful for qualitative and quantitative assessments of existing publications on a given topic. Several petroleum hydrocarbons are carcinogenic and immunotoxic agents, causing adverse effects on the biota, and the study of metabolites generated in bioremediation processes has been the object of current research. Therefore, in this work, the use of bibliometric analysis as a tool for surveying studies on the applied metabolomics bioremediation of areas impacted by hydrocarbons is presented. A bibliometric review was carried out in the Scopus Preview and Web of Science databases with data analysis using RStudio software with the bibliometrix package. The survey gathered the studies and prominent publications of the last seven years, making it possible to present gaps and opportunities in the area. reviews processing topic agents biota research Therefore work presented package years area

https://doi.org/10.21577/0100-4042.20170960

10.

Evaluation of nutritional composition of flour residue of mangaba processing
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Vasconcelos, K. M. C. S. G.

; Costa, J. G.

; Pavão, J. M. S. J.

; Fonseca, S. A.

; Miranda, P. R. B.

; Matos-Rocha, T. J.

; Freitas, J. D.

; Sousa, J. S.

; Melo, I. S. V.

; Santos, A. F.

Brazilian Journal of Biology

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2023, Volume 83 elocation e248931

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Dentre as diversas frutas a mangaba (Hancornia speciosa Gomes), despertou interesse de produtores e consumidores devido às suas características sensoriais atrativas e propriedades benéficas à saúde (elevado valor nutricional e presença de substâncias bioativas), assim, o trabalho avaliar os fatores nutricionais do resíduo da farinha de processamento de mangaba que é desprezado pela indústria alimentícia e, a influência da temperatura na sua produção. O resíduo de processamento da mangaba foi dividido em dois lotes, sendo um deles utilizado para as análises in natura (amostra controle) e o outro para a confecção da farinha que foi seca a 50 °C, e dividida em dois lotes: tratamento A (farinha com torras a 110 °C e 130 °C) e no tratamento B (farinha oriunda da secagem a 50 °C). Analisou-se as características nutricionais de farinhas considerando os parâmetros químicos: pH, acidez total titulável e sólidos solúveis, além da determinação do teor de umidade, lipídios totais, fibra alimentar total e cinzas, valor energético total, atividade antioxidante, triagem fitoquímica, quantificação de compostos fenólicos e flavonoides, bem como as propriedades funcionais tecnológicas (índice de absorção de água (IAA), índice de solubilidade em água (ISA), índice de absorção de leite (IAL) e índice de solubilidade em leite (ISL) e índice de absorção de óleo (IAO). Na análise foi inferido que os compostos bioativos presentes nos extratos não possuem propriedades significativas de agir como sequestradores de radicais livres. O tratamento térmico, realizado na farinha de resíduos de processamento de mangaba, influenciou nos dados dos fatores nutricionais e das propriedades de absorção e solubilidade, os quais apresentaram diferenças estatísticas. Estes resultados credenciam a farinha como uma alternativa viável para o enriquecimento energético de dietas, contribuindo para o desenvolvimento de novos produtos, a redução do descarte desses resíduos e consequentemente para a minimização do impacto ambiental.

Abstract Among several fruits, mangaba (Hancornia speciosa Gomes), it aroused the interest of producers and consumers due to its attractive sensory characteristics and health beneficial properties (high nutritional value and presence of bioactive substances), thus, this work evaluates the nutritional factors of the flour residue of mangaba processing that is despised by the food industry, and the influence of temperature on its production. The mangaba processing residue was splited in two main groups: in natura sample (control), and other for preparation of flour that was dried at 50 °C and divided into two other groups: treatment A (flour with roasts at 110 °C and 130 °C) and treatment B (flour from drying at 50 °C). The nutritional characteristics of flours were analyzed considering the chemical parameters: pH, titratable total acidity and soluble solids, in addition to the determination of moisture content, total lipids, total dietary fiber and ash, total energy value, antioxidant activity, phytochemical screening, quantification of phenolic compounds and flavonoids, as well as technological functional properties (water absorption index (WAI), water solubility index (WSI), milk absorption index (MAI) and milk solubility index (MSI) and oil absorption index (OAI). The results showed that the bioactive compounds present in the extracts do not have significant properties of acting as free radical kidnappers. The heat treatment, performed in the flour of mangaba processing residues, influenced the nutritional factors and properties of absorption and solubility, which showed statistical differences. These results show that the flour is a viable alternative for the energy enrichment of diets, contributing to the development of new products, the reduction of the disposal of these residues and consequently to the minimization of the environmental impact.

https://doi.org/10.1590/1519-6984.248931 116 downloads

11.

Bioactive properties of Persea lingue Ness (Lauraceae) fruit and leaf extracts
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Lillo, A.

; Carvajal-Caiconte, F.

; Vital, W.

; Silva Junior, P. I.

; Paredes-Gamero, E. J.

; Alvear, M.

; Miranda, A.

Brazilian Journal of Biology

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2023, Volume 83 elocation e248063

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Persea lingue Ness é uma árvore que vive principalmente na floresta temperada do centro-sul do Chile. As folhas são usadas na etnomedicina. O fruto é uma drupa similar ao abacate e que nunca foi pesquisada anteriormente. O objetivo deste estudo foi o de avaliar a citotoxicidade em células leucêmicas e as atividades antibacterianas, assim como algumas características químicas do extrato de fruto e da folha do P. lingue. As atividades antibacterianas foram determinadas pelo método da inibição do crescimento bacteriano em meio líquido empregando-se bactérias Gram-positivas e Gram-negativas. As linhagens celulares leucêmicas, Kasumi-1 e Jurkat foram usadas para avaliar a atividade citotóxica em ensaios empregando-se iodeto de propídio e AlamarBlue. Foram avaliados os teores totais de fenóis, flavonóides, taninos condensados, alcalóides e lipídeos presentes nos extratos das folhas e dos frutos. As atividades antioxidantes de ambos os extratos também foram avaliadas. O extrato das folhas foi o que apresentou o maior conteúdo de fenóis, taninos condensados e flavonóides totais e a maior atividade antioxidante. Já o extrato de fruto apresentou a maior quantidade de lipídios e alcaloides e a melhor atividade antibacteriana contra Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus megaterium e Micrococcus luteus. Já o extrato das folhas apresentou apenas atividade contra M. luteus. Em relação à atividade citotóxica, apenas o extrato do fruto apresentou citotoxicidade contra as linhagens celulares Jurkat e Kasumi-1. Em resumo, o extrato do fruto de P. lingue é uma potencial fonte de moléculas com atividade biológica para o desenvolvimento de novos fármacos a serem utilizados em alguns tipos de leucemia, bem como agente antibacteriano.

Abstract Persea lingue Ness is a tree species that lives mainly in temperate forests of south-central Chile. Its leaves are used in ethnomedicine, the fruit is a drupe similar to that of the avocado and has not been studied. The aim of this study was to determine the cytotoxicity in leukemia cell and antibacterial activity, along with some chemical content characteristics of P. lingue fruit and leaf extracts. The antibacterial activity was determined by the inhibition of bacterial growth in liquid medium assay against Gram-positive and Gram-negative bacteria. The leukemia cell lines Kasumi-1 and Jurkat were used to evaluate the cytotoxic activity by using propidium iodide and AlamarBlue assays. Total phenolic, flavonoid, condensed tannin, alkaloid and lipid contents were evaluated in the fruit and in the leaf extracts. The antioxidant activity of both extracts were also elavaluated. Leaf extract presented the highest content of total phenols, condensed tannins and flavonoids, and also the highest antioxidant activity. While the fruit extract has a higher amount of lipids and alkaloids and the high antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus megaterium and Micrococcus luteus. The leaf extract only showed activity against M. luteus. Concerning the cytotoxic activity, only the fruit extract showed cytotoxicity against the cell lines Jurkat and Kasumi-1. P. lingue fruit extract is a potential source of biologically active molecules for the development of new drugs to be used in some types of leukemia, as well as antibacterial agent.

https://doi.org/10.1590/1519-6984.248063 158 downloads

12.

Performance of EPDM Composites Under Thermal Plasma Ablative Tests
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Miranda, F. S.

; Prado, E. S. P.

; Silva, R. J.

; Ribeiro, A. M.

; Caliari, F. R.

; Calciolari, F. L.

; Sobrinho, A. S. Silva

; Petraconi, G.

Materials Research

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2023, Volume 26 elocation e20220326

Resumo: En | Texto: En | PDF: En

Abstract In this work, a thermal plasma-based ablation test system was used to evaluate the ablative performance of the EPDM composite. The system produces a high enthalpy plasma jet generated by a plasma (DC) torch, operating at atmospheric pressure using compressed air as working gas, enabling the variation of the thermal flux concerned with the studied EPDM composites. The samples were characterized using Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), Fourier-Transform Infrared spectroscopy (FTIR), and Thermogravimetric Analysis (TGA) to investigate the morphology, mass-loss rate, the reaction layer (char formation), and chemical changes of the samples for each thermal flux. For a complete evaluation, the thermal fluxes were varied in 0.30, 0.45, 0.60, 0.75, and 0.90 MW/m2 and for each thermal flux, disk-shape samples remained exposed to the plasma jet for 10s. During the plasma jet exposure time, the temperatures of the surface and the back of the samples were collected to verify the formed char layer's insulator capacity and the samples' thermal diffusivity for each experimental condition. The mass loss is continuous under the thermal fluxes of 0.30 and 0.45 MW/m2, stabilizing at 60% until 0.75 MW/m2. The formed char layer begins to lose its protective capacity, evidenced by the size decrease (from 800 µm to 700 µm), due to the ablation process of the reaction layer from the thermal flux of 0.90 MW/m2.

https://doi.org/10.1590/1980-5373-mr-2022-0326

13.

Organic minerals, tributyrin, and blend of organic acids in the diet of commercial laying hens at the end of production
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Miranda, D. A.

; Moreira, L. F. S.

; de Almeida, A. A.

; Vieira-Filho, J. A.

; M., L. C.

; Valentim, J. K.

; Oliveira, H. F.

; Geraldo, A.

South African Journal of Animal Science

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2023, Volume 53 Nº 1 Páginas 8 - 16

Resumo: En | Texto: En | PDF: En

This study aimed to evaluate the responses in performance, egg quality, and health of internal organs of laying hens of Hisex White lineage. The birds were provided with diets supplemented with organic minerals (OM) + tributyrin, associated or not with a mixture of organic acids (benzoic formic, citric, and phosphoric), compared to a control treatment containing zinc bacitracin (28 ppm). In total, 160 laying hens of the commercial Hisex White lineage of 68 w and an average weight of 1.735 ± 0.025 kg were distributed in 40 experimental plots. The study employed a completely randomized design, with five treatments and eight replications/treatment. The experimental period was divided into seven production cycles of 21 days, totalling 147 experimental days. The variables analysed were egg production and loss, feed intake, mean egg weight, egg mass, feed conversion, and internal and external quality variables of eggs. At the end of the experimental period, the final weight of the birds was measured to evaluate the relative weight of liver and kidneys. No significant effect of the treatments on the productive performance and internal and external quality of the eggs was evident. The association of organic minerals with a mixture of organic acids and tributyrin did not influence the productive performance and internal and external quality of the shell of Hisex White laying hens in the period from 68 to 89 weeks of age.

https://doi.org/10.4314/sajas.v53i1.02

14.

Modeling of biomass and stored carbon in a seasonal semidecidual forest in Brazil
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WATZLAWICK, LUCIANO F.

; LISBOA, GERSON S.

; FRANÇA, LUCIANO C.J.

; STEPKA, THIAGO F.

; LONGHI, RÉGIS V.

; MARANGON, GABRIEL P.

; MIRANDA, DIRCEU LÚCIO C. DE

; VERES, QOHÉLET JOSÉ I.

; SERPE, EDSON LUIS

; CERQUEIRA, CLEBSON L.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 4 elocation e20200656

Resumo: En | Texto: En | PDF: En

Abstract This study estimated biomass and carbon from components, future carbon values and to obtain economic productive value of carbon fixation of a Seasonal Semideciduous Forest. Biomass and carbon were estimated using adjusted equations and selected using regression statistics. The prognosis of the diametric distribution was performed using the movement ratio method. In the economic evaluation, it was estimated productive value of the stand, referring to the current and future carbon fixation capacity. The coefficients of determination (adjusted R²) of the equations ranged from 0.11 to 0.90 and the standard error of the estimate (Syx) ranged from 41.53% to 141.89% for the biomass of the components, and from 0.03 to 0.87 for adjusted R² and from 46.20% to 143.64% for the error, for stored carbon in the components. The total biomass of the tree component estimated was 56.25 t ha-1 and 25.88 t ha-1 of total carbon. Using the future distributions by the method of the ratio of movements, total stored carbon (aerial + roots) estimated was 14.44 t. ha-1 over the 20-year period. The productive value for the fragment reached R$ 299.95 per ha. year-1.

https://doi.org/10.1590/0001-3765202320200656

15.

Cross-cultural adaptation, validity, and reliability of the Child and Adolescent Behavior Inventory (CABI) for use in Brazil
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Costa, Danielle S.

; Cianchetti, Carlo

; Dewey, Deborah

; Alvim-Soares, Antônio Marcos Alvim-Soares

; Kestelman, Iane

; da Silva, Antônio Geraldo

; Malloy-Diniz, Leandro F.

; Miranda, Debora M.

; de Paula, Jonas J.

Jornal de Pediatria

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2023, Volume 99 Nº 4 Páginas 413 - 422

Resumo: En | Texto: En | PDF: En

Abstract Objective The Child and Adolescent Behavior Inventory (CABI) is a cost-free 75 question-questionnaire developed by an Italian group to collect information from parents on the behavior of children and adolescents aged 6 to 18 years. It assesses different areas of children's behavior and psychopathology, including internalizing and externalizing symptoms, and can be used to identify children at risk of mental disorders both in clinical and epidemiological settings. In this study, the authors present a Brazilian-Portuguese adaptation of the CABI and its psychometric properties. Methods First, the authors conducted a rigorous transcultural adaptation of CABI's questions and instructions for the Brazilian context. In an online sample of 598 parents, the authors found high reliability (internal consistency) for the CABI's main subscales. Results Validity was supported by exploratory factor analysis (the authors found 6 factors representing several aspects of psychopathology both according to the DSM and HiTop models) and significant differences in most CABI's subscales between children with parent-reported psychopathology and typically developing ones. The present study suggests that the adapted version of CABI is a valid and reliable measure that can be used in Brazil. Conclusions The CABI can be useful to the pediatrician to get fast but wide information from parents on the behavioral condition of their children or adolescents, and also to decide whether it is appropriate to consult a mental health professional.

https://doi.org/10.1016/j.jped.2023.02.008

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