ABSTRACT Food availability is defined as the sufficient quantity of food of adequate quality and culturally acceptable for the population of a country in a given period. In the case of the cities of the North Coast of the Uruguay River, there is little availability in terms of local fishing. The objectives of this research were to analyze the causes of this scarce availability through the opinion of the artisanal fishermen of the region, and the referring institutions. Semi-structured interviews were conducted with artisanal fishermen and institutional references in the region, as well as a representative of the private sector. The inability of fishermen to dedicate themselves exclusively to the activity; the export destination that has the majority of the region's catches; the low consumption at national level and the scarce demand of the cities for river fish, were some of the enunciated causes.

RESUMEN La disponibilidad de alimentos se define como la cantidad suficiente de alimentos de calidad adecuada y culturalmente aceptables para la población de un país en un período determinado. En el caso de las ciudades del Litoral Norte del Río Uruguay, se observa una escasa disponibilidad en materia de pesca local. Los objetivos de esta investigación fueron analizar las causas de esta escasa disponibilidad a través de la opinión de los y las pescadores artesanales de la región, y las instituciones referentes. Se realizaron entrevistas semi estructuradas a pescadores artesanales y referentes institucionales de la región, así como a un representante del sector privado. La imposibilidad de los pescadores para dedicarse exclusivamente a la actividad; el destino exportador que tiene la mayoría de las capturas de la región; el bajo consumo a nivel nacional y la escasa demanda de las ciudades por pescado de río, fueron algunas de las causas enunciadas.

Resumo A presente pesquisa foi feita para determinar a capacidade micronuclei e citotóxica do antidepressivo venlafaxina em ensaios agudos e subcrônicos in vivo em camundongos. No primeiro estudo, administramos uma vez 5, 50 e 250 mg/kg do medicamento e incluímos um grupo negativo e um grupo tratado com daunorubicina. As observações foram feitas diariamente durante quatro dias. O ensaio subcrônico durou cinco semanas com administração diária de venlafaxina (1, 5, e 10 mg/kg) mais um grupo negativo e um grupo administrado de imipramina. As observações foram feitas a cada semana. No primeiro ensaio, os resultados não mostraram aumento de eritrócitos policromáticos micronucleados (MNPE), exceto com a dose elevada a 72 h. O efeito citotóxico mais forte foi encontrado com 250 mg/kg a 72 h (um efeito citotóxico de 51% em comparação com o nível médio de controle). No ensaio subcrônico não foi encontrado aumento de MNPE; entretanto, com a dose mais alta, um aumento significativo de eritrócitos normocromáticos micronucleados foi observado nas últimas três semanas (média de 51% em relação ao valor médio de controle). Foi observado um efeito citotóxico com as duas altas doses nas últimas duas semanas (uma diminuição média de 52% em relação ao valor médio de controle dos eritrócitos policromáticos). Os resultados sugerem cautela com a venlafaxina.

Abstract The present research was made to determine the micronuclei and cytotoxic capacity of the antidepressant venlafaxine in an in vivo acute and subchronic assays in mouse. In the first study, we administered once 5, 50, and 250 mg/kg of the drug, and included a negative and a daunorubicin treated group. Observations were daily made during four days. The subchronic assay lasted 5 weeks with daily administration of venlafaxine (1, 5, and 10 mg/kg) plus a negative and an imipramine administered groups. Observations were made each week. In the first assay results showed no micronucleated polychromatic erythrocytes (MNPE) increase, except with the high dose at 72 h. The strongest cytotoxic effect was found with 250 mg/kg at 72 h (a 51% cytotoxic effect in comparison with the mean control level). In the subchronic assay no MNPE increase was found; however, with the highest dose a significant increase of micronucleated normochromatic erythrocytes was observed in the last three weeks (a mean of 51% respect to the mean control value). A cytotoxic effect with the two high doses in the last two weeks was observed (a polychromatic erythrocyte mean decrease of 52% respect to the mean control value). Results suggest caution with venlafaxine.

ABSTRACT BACKGROUND: Ankle taping (AT) is effective in preventing ankle sprain injuries in most common sports and is employed in rehabilitation and prevention sports. OBJECTIVE: This study aimed to investigate the effectiveness of AT to restricting excessive frontal plane ankle movements in semi-professional basketball players throughout the training session. DESIGN AND SETTING: A cross-sectional study was performed at the Universidad Europea de Madrid. METHODS: Forty male and female semi-professional basketball players were divided into two groups. The ankle dorsiflexion range of motion (ROM) and interlimb asymmetries in a weight-bearing lunge position were evaluated at four time points: 1) with no tape, 2) before practice, at 30 min of practice, and 3) immediately after practice. RESULTS: In male basketball players, no differences were observed in the right and left ankles between the baseline and 30 min and between baseline and 90 min of assessment. In female athletes, significant differences were reported between baseline and pre-training assessments for the right ankle and also significant differences between baseline and 90 min in both ankles. CONCLUSIONS: Ankle taping effectively decreased the ankle dorsiflexion ROM in male and female basketball players immediately after application. However, ROM restriction was very low after 30 and 90 min, as assessed in a single basketball practice. Therefore, the classic taping method should be revised to develop new prophylactic approaches, such as the implementation of semi-rigid bracing techniques or the addition of active stripes during training or game pauses.

ABSTRACT BACKGROUND: Current research supports the fact that prophylactic ankle taping (AT) is effective in preventing ankle injuries in amateur and elite sports athletes. OBJECTIVE: This study aimed to investigate the effect of AT on balance, knee valgus during drop jump and single-leg countermovement jump (SL-CMJ) landings, and ankle range of motion (ROM) restriction in healthy participants. DESIGN AND SETTING: A cross-sectional observational study was conducted at the Universidad Europea de Madrid, Madrid, Spain. METHODS: Participants: Thirty-nine healthy individuals participated in this study and performed the movements under two conditions (with and without tape). Outcome measurements: ankle ROM, balance, SL-CMJ height, flight time, ground time, and knee valgus. Before any intervention, a random process was developed with a 1:1 allocation ratio, and the participants were assigned to groups A (tape-no tape) and B (no tape-tape). RESULTS: Significant differences between tape and no-tape moments were observed for drop jump knee valgus flexion (P = 0.007), with an increase in knee valgus in participants with ankle taping. Similarly, the Y-balance testshowed a significant decrease in all variables (P = 0.001 and), ankle dorsiflexion (P = 0.001) in participants with ankle taping. CONCLUSIONS: AT is effective for immediate ankle ROM restriction. However, an increase in knee valgus during drop jump task and a decrease in lower limb balance were observed during drop jump task. Based on these results, it can be concluded that AT application in healthy individuals should not be recommended as it results in increase in injury risk factors.

Resumen Introducción: El Trastorno por Déficit de Atención e Hiperactividad es el desorden pediátrico del neurodesarrollo más frecuente. Los estudios en México que evalúan Calidad de vida y características cognitivas son escasos. Objetivo: Describir la relación entre las características cognitivas y la calidad de vida en niños con trastorno por déficit de atención e hiperactividad en Puebla, México. Método: Se realizó un estudio transversal, analítico en un Hospital de 2º nivel de atención en Puebla, México. Se incluyeron pacientes con Trastorno por Déficit de Atención e Hiperactividad de 6 a 12 años. Se excluyeron aquellos con discapacidad visual/auditiva y retraso severo del lenguaje. Se eliminaron quienes no completaron la información. Se les aplicó WISC-IV, Neuropsi y BMSLSS (como indicador de Calidad de Vida). Se utilizó Coeficiente de Spearman; p ≤ 0.05 se consideró significativa. Resultados: 104 niños reclutados, 71 hombres (68.26%), edad media 8.94 años (DE 1.83, mín. 6, máx. 12). Los dominios más afectados fueron Memoria de trabajo, Velocidad de procesamiento (WISC-IV), y Atención y memoria (Neuropsi). La Calidad de Vida fue mayoritariamente baja (60%). Coeficiente intelectual (WISC-IV) (r = 0.3962, p = 0.000) y Atención y memoria (Neuropsi) (r = 0.451, p = 0.018) reportaron correlación moderada significativa con Calidad de vida. Conclusión: Atención, Memoria y Velocidad de procesamiento son las características cognitivas más afectadas en niños con Trastorno por Déficit de Atención e Hiperactividad. La Calidad de vida es baja. Coeficiente intelectual y Atención y memoria reportaron correlación moderada significativa con Calidad de Vida.

Abstract Background: Attention deficit hyperactivity disorder (ADHD) is the most frequent pediatric neurodevelopmental disorder. Studies in Mexico about health-related quality of life (QOL) and cognitive characteristics in these patients are scarce. Objectives: The objective of this study is to describe the relationship between cognitive characteristics and health-related QOL in children with ADHD in Puebla, Mexico. Method: A cross-sectional, analytical study was carried out in a second-level care hospital in Puebla, Mexico. Both genders, from 6 to 12 years old patients with ADHD were included. Those with visual/hearing disabilities and/or severe language delays were excluded. Patients who did not complete the information were eliminated. The Wechsler Intelligence Scale for Children IV (WISC-IV), The Neuropsi and Brief Multidimensional Life Satisfaction Scale for Students (as health-related QOL indicator) scales were applied. Spearman test was used; p ≤ 0.05 was considered significant. Results: 104 children were recruited, 71 male (68.26%), medium age was 8.94 years old (SD = 1.83, min = 6, max = 12). Work memory and processing speed (WISC-IV), and memory and attention (Neuropsi) were the most affected domains. Health-related QOL was low at 60%. WISC-IVs intellectual quotient (r = 0.3962, p = 0.000), and Neuropsi's memory and attention (r = 0.451, p = 0.018) reported a significant moderated correlation with health-related QOL. Conclusion: Attention, memory, and processing speed were the most affected cognitive characteristics in children with attention deficit/hyperactivity disorder. Health-related QOL resulted low. Intellectual coefficient, as well as memory and attention, reported a significant moderated correlation with health-related QOL.

Resumen: Antecedentes: El conocimiento de los atributos estructurales y el hábitat de las especies son fundamentales para evaluar su estado de conservación y proponer acciones para su conservación y manejo. Preguntas: ¿Cuáles son los atributos estructurales de la poblacional de J. jaliscana, las características de su hábitat y los factores ambientales que podrían estar influyendo en su distribución y abundancia? Sitio y periodo de estudio: El muestreo de campo se realizó en poblaciones de J. jaliscana en el ejido El Cuale, municipio de Talpa de Allende, Jalisco, México, en julio de 2019. Métodos: En parcelas de 500 m2 se determinaron los atributos estructurales de la poblacional de J. jaliscana y a través de un RDA se evaluó cuales factores ambientales podrían influir en su distribución y abundancia. Se describió la composición y estructura de toda la comunidad vegetal. Resultados: Juniperus jaliscana registró 385 ind. ha-1 y un área basal de 8.98 m2 ha-1. Las variables con mayor influencia sobre su abundancia y distribución fueron la incidencia de incendios y el pastoreo. Se registraron 119 especies, 94 géneros y 52 familias. Psidium salutare se registró por primera vez para el estado de Jalisco y se describió como especie nueva para la ciencia a Prionosciadium tamayoi. Conclusiones: Juniperus jaliscana concentró su población en categorías diamétricas pequeñas. Los factores ambientales con mayor influencia sobre su distribución y abundancia fueron los incendios, pastoreo y condiciones de ambientes secos. Juniperus jaliscana comparte hábitat con especies endémicas al occidente de México.

Abstract: Background: Knowledge of structural attributes and the habitat of the species is essential to assess their conservation status and propose actions for their conservation and management. Questions: What are the structural attributes of the population of J. jaliscana, the characteristics of its habitat, and the environmental factors that could be influencing its distribution and abundance? Study site and dates: The field sampling was carried out in populations of J. jaliscana in ejido El Cuale, municipality of Talpa de Allende, Jalisco, México, in July 2019. Methods: In plots of 500 m2, the structural attributes of the population of J. jaliscana were determined and through an RDA, the environmental factors that could be influencing its distribution and abundance were investigated. The composition and structure of the entire community was described. Results: Juniperus jaliscana registered 385 ind. ha-1 and a basal area of 8.98 m2 ha-1. The variables with the greatest influence on the abundance and distribution of J. jaliscana were the incidence of fires and grazing. 119 species, 94 genera and 52 families were recorded. Psidium salutare was found for the first time for the state of Jalisco and Prionosciadium tamayoi was described as a new species for science. Conclusions: Juniperus jaliscana concentrated its population in small diameter categories. The environmental factors with the greatest influence on their distribution and abundance were fires, grazing and dry environment conditions. The habitat of J. jaliscana was shared with species endemic to western Mexico.

Resumen Objetivo: Describir aspectos clínicos, microbiológicos y ecocardiográficos de endocarditis en un grupo específico de pacientes sin dispositivos intracardiacos ni cardiopatía estructural subyacente. Método: Estudio retrospectivo en el que se revisaron expedientes clínicos y reportes ecocardiográficos durante el periodo de 1997 a 2020. Se aplicaron los criterios modificados de Duke. Se describió la muestra por edad, sexo, enfermedad sistémica, vegetaciones y agente microbiológico. Se excluyeron pacientes con cardiopatía estructural o Libman-Sacks. Análisis estadístico: univariado expresado en frecuencias, utilizando medidas de dispersión y tendencia central. Resultados: Se revisaron 30,000 reportes ecocardiográficos, de los cuales solo 1350 tenían como motivo de envío endocarditis infecciosa, y de estos se seleccionaron 248 casos. La edad promedio fue de 48.1 ± 16.7 años. Hubo 140 hombres (56%) y 108 mujeres (44%). El signo ecocardiográfico más frecuente fue la vegetación, en 278 (93.60%), y la ubicación más común fue mitral (35.55%), con un número mayor de casos en el ventrículo derecho de lo esperado. La enfermedad sistémica más común fue la enfermedad renal, en 135 (41.08%). Se identificó un caso de Streptococcus thoraltensis no reportado previamente en México. Conclusiones: La presencia de endocarditis infecciosa ha aumentado debido a procedimientos invasivos intrahospitalarios y fármacos. Por su complejidad, los equipos multidisciplinarios son indispensables.

Abstract Objective: To describe clinical, microbiological and echocardiographic aspects of endocarditis in a specific group of patients without intracardiac devices or underlying structural heart disease. Method: Retrospective study, clinical records and echocardiographic reports were reviewed during the period 1997 to 2020. Duke’s modified criteria were applied. Statistical analysis: univariate expressed in frequencies, using measures of dispersion and central tendency. Results: 30,000 echocardiographic reports were reviewed, only 1350 had infectious endocarditis as a reason for sending, of which 248 cases were selected. The mean age was 48.1 ± 16.7 years. 140 men (56%) and 108 women (44%). The most frequent echocardiographic sign was vegetation, in 278 (93.60%), and most common location was mitral (35.55%), with a higher number of cases in the right ventricle than expected. The most common systemic disease was kidney disease, in 135 (41.08%). A case of Streptococcus thoraltensis not previously reported in Mexico was identified. Conclusions: The presence of infectious endocarditis has increased due to invasive in-hospital and drug procedures. Due to their complexity, multidisciplinary teams are indispensable.

Resumen En Colombia, los anfibios se posicionan como uno de los grupos vertebrados con mayor riqueza taxonómica, y una alta representatividad de especies endémicas. En los últimos años, las colecciones regionales han contribuido a llenar vacíos de información sobre la biogeografía, la variación intra e interespecífica y la sistemática de los anfibios del país. En este trabajo presentamos la información de 1533 registros depositados en la Colección de Anfibios del Museo de Historia Natural de la Universidad de Caldas, los cuales representan 143 especies distribuidas en 49 géneros y 19 familias. La mayoría de los especímenes (n = 1194) proceden del departamento de Caldas, sin embargo, se cuenta con registros (n = 339) de otros 16 departamentos del país. El orden más representado es Anura (n = 1487 registros), seguido por Caudata (n = 27 registros) y Gymnophiona (n = 19 registros). La colección alberga 152 especímenes que han sido referenciados en 13 publicaciones nacionales y extranjeras.

Abstract In Colombia, amphibians are a vertebrate group with a high taxonomic richness, and an elevated representativity of species with restricted distributions. In recent years, regional collections have assisted to fill information gaps on the biogeography, intra- and interspecific variation, and systematics of the amphibians of the country. In this work we present the information of 1533 records deposited in the Amphibian Collection of the Museo de Historia Natural of the Universidad de Caldas, represented by 143 species, belonging to 49 genera and 19 families. Most of the records (n = 1194) come from the Department of Caldas, but there are records for 16 additional departments. The most representative order is Anura (n = 1487 records) followed by Caudata (n = 27 records), and Gymnophiona (n = 19 records). The collection houses 152 specimens that have been referenced in 13 national and foreign publications.

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

Resumen Objetivo: Identificar los factores asociados a la sobrevida a un año en pacientes postoperados de glioblastoma en un hospital del noreste de México. Material y métodos: Estudio de casos y controles anidado en una cohorte. Se incluyeron pacientes operados de glioblastoma entre 2016 y 2019. Se obtuvo la información sobre factores clínicos y quirúrgicos, se calculó la sobrevida mediante análisis de Kaplan-Meier. El análisis descriptivo se realizó con medianas y rangos, y el inferencial con prueba de χ2, Fisher, t de Student, razón de momios e intervalo de confianza al 95%. Se consideró significativo un valor de p < 0.05. Resultados: Se incluyeron 62 pacientes con glioblastoma, 27 (43.5%) mujeres y 35 (56.5%) hombres, mediana de edad de 56 años (rango: 6-83). La mediana de sobrevida fue de 3.6 meses (1-52), 45 (72.6%) sobrevivieron menos de 12 meses. Los factores asociados a mayor sobrevida fueron: administración de tratamiento adyuvante (p < 0.001), mejor estado funcional (p = 0.001) y ausencia de complicaciones posquirúrgicas (p = 0.034). Conclusiones: La mayoría de los pacientes con glioblastoma sobreviven menos de 12 meses y los factores más fuertemente asociados a mayor sobrevida son administración de tratamiento adyuvante, mejor estado funcional del paciente y ausencia de complicaciones posquirúrgicas.

Abstract Objective: To identify factors associated with one-year survival in postoperative glioblastoma patients at a hospital in northeastern Mexico. Material and methods: Nested case-control study. Patients operated on for glioblastoma between 2016-2019 were included. Information about clinical and surgical factors was obtained, survival was calculated by Kaplan-Meier analysis. Descriptive analysis was performed with medians and ranges, and inferential analysis with χ2, Fisher and Student t test, odds ratio and 95% confidence interval. A value of p < 0.05 was considered significant. Results: Sixty-two patients with glioblastoma were included, 27 (43.5%) women and 35 (56.5%) men, median age 56 years (range: 6-83). Median survival was 3.6 months (1-52), 45 (72.6%) survived less than 12 months. The factors associated with a higher survival were administration of adjuvant treatment (p < 0.001), better functional status (p = 0.001), and absence of post-surgical complications (p = 0.034). Conclusions: Most patients with glioblastoma survive less than 12 months and the factors most strongly associated with longer survival are administration of adjuvant treatment, better functional status of the patient and absence of post-surgical complications.

ABSTRACT Objectives: To determine the frequency of depression and anxiety among Latin American medical students during social distancing in the COVID-19 outbreak period. Methods: Observational, descriptive and cross-sectional design, the study included all Latin American medical students affiliated to the Federación Latinoamericana de Sociedades Científicas de Estudiantes de Medicina (FELSOCEM) selected through non-probabilistic convenience sampling who agreed to participate in the study. Data was collected through a questionnaire, consisting primarily of socio-demographic characteristics such as age, gender, marital status, and country of origin; as a second section, the Goldberg depression and anxiety test was applied, and an analysis was carried out by the nature of the variables. The research protocol was approved by an institutional ethics committee. Results: Of 1579 participating students, from 15 Latin American countries, 68.59% (1083) were women, 65.04% (1027) were between 20 and 24 years old, 95.63% (1510) were single, 23.18% (366) lived in Panama and 11.08% (175) in Chile. 87.14% (1376) have symptoms of anxiety, 66.88% (1056) have symptoms of depression and 64.34% (1016) have both symptoms. Conclusions: A high percentage of medical students in Latin American population suffered symptoms of anxiety and depression during the social distancing measures in the covid-19 outbreak period, data that must be taken into account for future mental health strategies.

RESUMEN Objetivos: Determinar la frecuencia de depresión y ansiedad en estudiantes de la carrera de medicina de Latinoamérica durante el distanciamiento social en el período de brote del COVID-19. Métodos: Diseño observacional, descriptivo y corte transversal, se incluyó en el estudio todos los estudiantes de medicina de Latinoamérica que se encuentren afiliados a la Federación Latinoamericana de Sociedades Científicas de Estudiantes de Medicina (FELSOCEM) seleccionados a través del muestreo no probabilístico por conveniencia que accedieron participar del estudio. Mediante un cuestionario se recopilaron datos, compuesto primeramente por características sociodemográficas como edad, género, estado civil y país de procedencia; como segunda sección, el instrumento estuvo compuesto por el test de depresión y ansiedad de Goldberg, se realizó un análisis en concordancia con la naturaleza de las variables. El protocolo de investigación fue aprobado por un comité de ética institucional. Resultados: De 1579 estudiantes participantes, de 15 países latinoamericanos, 68.59% (1083) fueron mujeres, 65.04% (1027) tenían entre 20 y 24 años, 95.63% (1510) eran solteros, 23.18% (366) vivían en Panamá y 11.08% (175) en Chile. El 87.14% (1,376) tienen síntomas de ansiedad, el 66.88% (1,056) tienen síntomas de depresión y el 64.34% (1,016) tienen ambos síntomas. Conclusiones: Un alto porcentaje de la población médico-estudiantil latinoamericana padecieron de síntomas de ansiedad y depresión durante las medidas de distanciamiento social en el periodo de brote del covid-19, dato que tiene que ser tomado en cuenta para futuras estrategias sobre salud mental.

Resumen Los coronavirus (CoV) causan enfermedades respiratorias y entéricas leves, graves o críticas, pudiendo ocasionar la muerte del paciente. Debido a la alta conectividad entre naciones y a la transmisión, actualmente la COVID-19 representa un verdadero problema de salud pública en todo el mundo. El CoV-2 causante del síndrome respiratorio agudo grave (SARS-CoV-2) apareció a finales de diciembre de 2019 en Wuhan, China, y en marzo de 2020 la COVID-19 fue declarada pandemia. En esta revisión se describen las características del genoma y de la proteína espiga del SARS-CoV-2, su papel en la inmunopatogénesis de la COVID-19, la tormenta de citocinas, la actividad citotóxica inducida por células T y la producción de anticuerpos contra el SARS-CoV-2 mediada por células B, así como la eficacia de algunas vacunas, tomando en cuenta las mutaciones presentes en la proteína espiga.

Abstract Coronavirus (CoV) infections cause respiratory and enteric diseases with clinical manifestations ranging from faint to severe, even lead to death of patients. High connectivity between nations and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represent a global health problem as the coronavirus disease 19 (COVID-19). This CoV-2 that cause SARS, which appeared in Wuhan, China, in December 2019 originated COVID-19 and declared as pandemic a few months posterior its appearance. In this review, the genomic and spike protein characteristics of SARS-CoV-2, the role of SARS-CoV-2 in the COVID-19 pathogenesis, cytokine storm, the role of cytotoxic T and B cells against SARS-CoV-2, as well as the vaccines efficacy (taking into account mutations in the spike protein) are described.

Resumen: En el presente estudio se examinan los factores que inciden en la tasa de titulación de estudiantes de pregrado en Chile. Utilizando un análisis estadístico descriptivo e inferencial de estudiantes que ingresaron a la educación superior en el año 2011, se analizan variables sociodemográficas, institucionales y académicas. Los resultados muestran que los estudiantes de estratos socioeconómicos altos tienen mayores probabilidades de titularse. Se observan diferencias significativas y una mayor probabilidad de titularse para las mujeres por sobre los hombres. Los estudiantes de institutos profesionales y centros de formación técnica tienen mayor probabilidad de titularse en comparación a quienes ingresan a una universidad. Similarmente, tienen más probabilidad de graduarse quienes obtuvieron un buen rendimiento académico en sus notas de enseñanza media y puntaje SIMCE en matemática. En conclusión, estos hallazgos sirven de guía para identificar los factores subyacentes de las tasas de titulación de estudiantes de educación superior en Chile y, en consecuencia, desarrollar políticas públicas para mejorarlas.

Abstract: The present study examines the factors that affect the graduation rate of undergraduate students in Chile. Using a descriptive and inferential statistical analysis of students who entered higher education in the year 2011, sociodemographic, institutional, and academic variables are analyzed. The results show that students from high socioeconomic strata are more likely to graduate. There are also significant differences and higher probability of graduation for women over men. In addition, students from professional institutes and technical training centers have a higher probability of graduating than university students. Similarly, students with both good high school grades and mathematics SIMCE scores also have an increased probability of completing their undergraduate degrees. In conclusion, these findings can serve as a guide to identify the factors affecting graduation rates of higher education students in Chile, which consequently, can assist in developing public policies to improve them.

Resumen Los elogios son definidos como devoluciones positivas otorgadas a personas sobre sus atributos, sobre la realización de una tarea o sobre los objetos o productos realizados. Los distintos tipos de elogios que los cuidadores primarios o padres utilicen con los infantes cuando ellos realicen una actividad impactarán en su desarrollo, en las creencias o percepción de sí mismos o de los modos de aprender, y en la motivación hacia esas tareas que la niña o el niño realice. Estos modos de elogiar no han sido estudiados en la Argentina y no existen instrumentos estandarizados psicométricos para evaluarlos. Por esto, el objetivo de este estudio fue la creación y validación de una técnica de auto-reporte para evaluar los elogios que otorgan los cuidadores a infantes de 0 a 3 años. Los participantes que conformaron la muestra (. = 128) fueron reclutados por medio de internet y completaron un cuestionario de escala Likert de aproximadamente cinco minutos de duración. A partir del análisis factorial exploratorio, se ajustó la técnica y se agruparon las preguntas del cuestionario en tres dimensiones: elogios de persona, proceso y producto. Esto permitiría hacer una evaluación breve y sencilla de los elogios utilizados, lo que en un futuro aportaría a intervenciones o estudios que pretendan favorecer elogios que beneficien un desarrollo adaptativo de los infantes. Sin embargo, aún es necesario un futuro estudio que indague cambios en la técnica con un mayor tamaño muestral para la realización de una validación más exhaustiva.

Abstract Praise is defined as positive feedback given to people about their attributes, their performance, the objects or products made by them. The different types of praise that primary caregivers or parents use with infants when they carry out an activity will impact on their development, beliefs or perception of themselves or types of learning, and motivation toward the tasks that the children perform. One type of praise is the praise directed towards an individual, which compliments their own attributes such as her intelligence. Another one is the product praise, which is directed towards the final objects or actions that the infant performs, such as a drawing or physical activities. Finally, a praise directed at the process aims to congratulate the infant during the task as a process, either for making an effort or for the strategies that they use to achieve something. This last kind of praise favors perseverance in the face of new tasks to a greater extent, while praise directed at the person could generate more frustration when the infant experiences failure. Therefore, the way caregivers interact with infants is relevant, since it modulates motivation and the development of different skills. For this reason, the main objective of this study was the creation and validation of a self-report technique to assess the praise that Argentinean caregivers give to infants from 0 to 3 years of age. The sample was made up of 128 primary caregivers (. = 128) who were recruited through the internet. They completed a Likert scale questionnaire of approximately 5 minutes of duration. The data was collected during preventive social isolation due to COVID-19. This could lead to changes in parental behavior, while it also provides ecological value for understanding the ways to praise in this context, where caregivers spend a lot of time with infants; however, it would be important to conduct future research outside of this context. An exploratory factor analysis was performed, which led to an adjustment in the technique by eliminating four items in order to improve the psychometric characteristics of the instrument. By this analysis, the formation of the three dimensions was justified by the types of praise: person, process, and product praise.The final instrument consisted of 13 phrases that represent possible compliments used by caregivers. Participants indicated how often they usually use those compliments on a scale from 1 (never) to 5 (very often). The items are divided by types of praise: six were assigned to the product dimension, three to the process dimension and four to the person dimension. The internal consistencies of the dimensions were process (α = .91), product (α = .74) and person (α = .73). This self-report technique for primary caregivers of infants would allow a short and simple evaluation of the praise used. In future research, this technique would allow an assessment of praise for the realization of studies that seek to expand the knowledge about how they affect child development. Likewise, it would contribute to the development of interventions with caregivers aimed to promote praise that benefits an adaptive development of infants. However, more studies are needed to investigate possible changes in the inventory, such as the inclusion of neutral praise or negative feedback. Furthermore, a larger sample size would be necessary to carry out a more exhaustive validation, performing a confirmatory factor analysis, convergent variance and factor invariance.